Bertha Madras, PhD (the Honorable) is a Professor of Psychobiology at Harvard Medical School (Harvard faculty 40 years). She is based at McLean Hospital and cross-appointed at the Massachusetts General Hospital. Scientific Research. Dr. Madras's translational and multidisciplinary research focuses on the neurobiology of addiction, neuropsychiatric disorders, and drug policy. Author She is author of more than 200 scientific manuscripts, reviews, and book chapters. She is co-editor of academic books The Cell Biology of Addiction and Effects of Drug Abuse on the Human Nervous System and Imaging of the Human Brain in Health and Disease. Intellectual Property She is an inventor and co-inventor on 19 issued U.S. patents and 27 issued international patents. Government, Other Service National Academy of Medicine Opioid Collaborative. Member (2018-present). United Nations Office on Drugs and Crime. Panel on Consequences of Drug Use (2024). President's Commission on Combating Drug Addiction and the Opioid Crisis. Appointed by President Trump as one of six Commission members: Gov. C. Baker (MA); Attorney General P. Bondi (FL); Gov. C. Christie (Chair, NJ); Gov. R. Cooper (NC); Congressman P. Kennedy (RI); Prof. Madras (MA). She was charged with shepherding and writing major components of the Commission Report (2017). Vatican Pontifical Academy of Sciences. Panelist on Narcotics; co-author of final report (2016). U.S. Department of Justice. Sole expert witness for DOJ on marijuana rescheduling (2014-2015). World Health Organization. Sole author of report commissioned by the World Health Organization, "Update of Cannabis and its Medical Use" (2015); co-author of The Health and Social Effects of Nonmedical Cannabis Use (2015). National Football League (NFL). Member, Committee on Prescription Drugs (2014). Deputy Director for Demand Reduction, White House Office of National Drug Control Policy (ONDCP), Executive Office of the President; presidential appointment confirmed with unanimous consent (99-0) by the U.S. Senate (2006-2009). Educational Outreach Cold Spring Harbor Laboratories. Developer of ongoing international course on the Cell Biology of Addiction. Museum of Science, Boston. Directed production of a museum exhibit, a CD (licensed by Disney), Changing Your Mind: Drugs in the Brain. DEA-NIDA Museum Exhibit. Wrote draft of storyboard for exhibit, 1 Times Square, NYC. Addictions Course. Developer and instructor for fourth-year HMS medical students. HarvardX. Developer of course for parents on drug prevention (2023-2025).
Professor of Psychobiology in the Department of Psychiatry, Part-time
Synthesis and preliminary characterization of a high-affinity novel radioligand for the dopamine transporter. Synapse. 2001 Feb; 39(2):175-81.
Synthesis and preliminary characterization of a high-affinity novel radioligand for the dopamine transporter.
Cannabinoid receptor agonist and antagonist effects on motor function in normal and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-treated non-human primates. Psychopharmacology (Berl). 2001 Jun; 156(1):79-85.
Cannabinoid receptor agonist and antagonist effects on motor function in normal and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-treated non-human primates.
Meltzer PC, Blundell P, Chen Z, Yong YF, Madras BK
Bioorganic & medicinal chemistry letters
Bicyclo[3.2.1]octanes: synthesis and inhibition of binding at the dopamine and serotonin transporters. Bioorg Med Chem Lett. 1999 Mar 22; 9(6):857-62.
Bicyclo[3.2.1]octanes: synthesis and inhibition of binding at the dopamine and serotonin transporters.
Non-amine dopamine transporter probe [(3)H]tropoxene distributes to dopamine-rich regions of monkey brain. Synapse. 1999 Oct; 34(1):20-7.
Non-amine dopamine transporter probe [(3)H]tropoxene distributes to dopamine-rich regions of monkey brain.
The President's Commission on Combating Drug Addiction and the Opioid Crisis: Origins and Recommendations. Clin Pharmacol Ther. 2018 06; 103(6):943-945.
The President's Commission on Combating Drug Addiction and the Opioid Crisis: Origins and Recommendations.
Ascorbate injury and EDTA (or manganese) protection of D2-dopamine receptors. Eur J Pharmacol. 1982 Jun 16; 81(1):111-6.
Ascorbate injury and EDTA (or manganese) protection of D2-dopamine receptors.
Madras BK, Fahey MA, Bergman J, Canfield DR, Spealman RD
The Journal of pharmacology and experimental therapeutics
Effects of cocaine and related drugs in nonhuman primates. I. [3H]cocaine binding sites in caudate-putamen. J Pharmacol Exp Ther. 1989 Oct; 251(1):131-41.
Effects of cocaine and related drugs in nonhuman primates. I. [3H]cocaine binding sites in caudate-putamen.
Xiao D, Miller GM, Jassen A, Westmoreland SV, Pauley D, Madras BK
Ephrin/Eph receptor expression in brain of adult nonhuman primates: implications for neuroadaptation. Brain Res. 2006 Jan 05; 1067(1):67-77.
Ephrin/Eph receptor expression in brain of adult nonhuman primates: implications for neuroadaptation.
Westmoreland SV, Annamalai L, Lentz MR, Ratai EM, Assaf B, Boisvert K, Huynh T, Vallender EJ, Miller GM, Madras BK, Gonzalez RG
Growth-associated protein-43 and ephrin B3 induction in the brain of adult SIV-infected rhesus macaques. J Neurovirol. 2011 Oct; 17(5):455-68.
Growth-associated protein-43 and ephrin B3 induction in the brain of adult SIV-infected rhesus macaques.
11C-WIN 35,428 for detecting dopamine depletion in mild Parkinson's disease. Ann Neurol. 1994 Mar; 35(3):376-7.
11C-WIN 35,428 for detecting dopamine depletion in mild Parkinson's disease.
Drug use among youth: National survey data support a common liability of all drug use. Prev Med. 2018 08; 113:68-73.
Drug use among youth: National survey data support a common liability of all drug use.
Xie Z, Westmoreland SV, Bahn ME, Chen GL, Yang H, Vallender EJ, Yao WD, Madras BK, Miller GM
Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro. J Pharmacol Exp Ther. 2007 Apr; 321(1):116-27.
Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro.
Purushotham M, Sheri A, Pham-Huu DP, Madras BK, Janowsky A, Meltzer PC
The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes. Bioorg Med Chem Lett. 2011 Jan 01; 21(1):48-51.
The synthesis and biological evaluation of 2-(3-methyl or 3-phenylisoxazol-5-yl)-3-aryl-8-thiabicyclo[3.2.1]octanes.
Candidate performance measures for screening for, assessing, and treating unhealthy substance use in hospitals. Ann Intern Med. 2011 Jan 04; 154(1):72-3; author reply 73-4.
Candidate performance measures for screening for, assessing, and treating unhealthy substance use in hospitals.
Distribution of cocaine recognition sites in monkey brain: I. In vitro autoradiography with [3H]CFT. Synapse. 1991 Nov; 9(3):177-87.
Distribution of cocaine recognition sites in monkey brain: I. In vitro autoradiography with [3H]CFT.
Spencer TJ, Biederman J, Ciccone PE, Madras BK, Dougherty DD, Bonab AA, Livni E, Parasrampuria DA, Fischman AJ
PET study examining pharmacokinetics, detection and likeability, and dopamine transporter receptor occupancy of short- and long-acting oral methylphenidate. Am J Psychiatry. 2006 Mar; 163(3):387-95.
PET study examining pharmacokinetics, detection and likeability, and dopamine transporter receptor occupancy of short- and long-acting oral methylphenidate.
Madras BK, Fahey MA, Goulet M, Lin Z, Bendor J, Goodrich C, Meltzer PC, Elmaleh DR, Livni E, Bonab AA, Fischman AJ
Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo. J Pharmacol Exp Ther. 2006 Nov; 319(2):570-85.
Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo.
Spencer TJ, Biederman J, Madras BK, Dougherty DD, Bonab AA, Livni E, Meltzer PC, Martin J, Rauch S, Fischman AJ
Further evidence of dopamine transporter dysregulation in ADHD: a controlled PET imaging study using altropane. Biol Psychiatry. 2007 Nov 01; 62(9):1059-61.
Further evidence of dopamine transporter dysregulation in ADHD: a controlled PET imaging study using altropane.
Methylphenidate elevates resting dopamine which lowers the impulse-triggered release of dopamine: a hypothesis. Behav Brain Res. 2002 Mar 10; 130(1-2):79-83.
Methylphenidate elevates resting dopamine which lowers the impulse-triggered release of dopamine: a hypothesis.
Meltzer; PC; Madras; BK.; Blundell; P; Chen; Z.
Tropane analogs and methods for inhibition of monoamine transport
Tropane analogs and methods for inhibition of monoamine transport. 2002.
Metabolism of alpha-methyltryptophan. Biochem Pharmacol. 1965 Nov; 14(11):1499-506.
Fernstrom JD, Hirsch MJ, Madras BK, Sudarsky L
Effects of skim milk, whole milk and light cream on serum tryptophan binding and brain tryptophan concentrations in rats. J Nutr. 1975 Oct; 105(10):1359-62.
Effects of skim milk, whole milk and light cream on serum tryptophan binding and brain tryptophan concentrations in rats.
Advances in biochemical psychopharmacology
Modulation of dopamine receptor binding by ascorbic acid. Adv Biochem Psychopharmacol. 1983; 37:275-87.
Modulation of dopamine receptor binding by ascorbic acid.
[3H]CFT ([3H]WIN 35,428) accumulation in dopamine regions of monkey brain: comparison of a mature and an aged monkey. Brain Res. 1993 May 21; 611(2):322-5.
[3H]CFT ([3H]WIN 35,428) accumulation in dopamine regions of monkey brain: comparison of a mature and an aged monkey.
Madras BK, Compton WM, Avula D, Stegbauer T, Stein JB, Clark HW
Screening, brief interventions, referral to treatment (SBIRT) for illicit drug and alcohol use at multiple healthcare sites: comparison at intake and 6 months later. Drug Alcohol Depend. 2009 Jan 01; 99(1-3):280-95.
Screening, brief interventions, referral to treatment (SBIRT) for illicit drug and alcohol use at multiple healthcare sites: comparison at intake and 6 months later.
Effects of cocaine and related drugs in nonhuman primates. II. Stimulant effects on schedule-controlled behavior. J Pharmacol Exp Ther. 1989 Oct; 251(1):142-9.
Effects of cocaine and related drugs in nonhuman primates. II. Stimulant effects on schedule-controlled behavior.
Madras BK, Spealman RD, Fahey MA, Neumeyer JL, Saha JK, Milius RA
Cocaine receptors labeled by [3H]2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane. Mol Pharmacol. 1989 Oct; 36(4):518-24.
Cocaine receptors labeled by [3H]2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane.
Cocaine analogues and their use as cocaine drug therapies and therapeutic and imaging agents for neurodegenerative disorders.
Cocaine analogues and their use as cocaine drug therapies and therapeutic and imaging agents for neurodegenerative disorders. 1996.
Cocaine analogues and their use as cocaine drug therapies and therapeutic and imaging agents for neurodegenerative disorders
Effect of yohimbine on tryptophan metabolism. J Pharmacol Exp Ther. 1969 Feb; 165(2):289-93.
Effect of yohimbine on tryptophan metabolism.
Partial purification of [3H]mianserin binding sites. Eur J Pharmacol. 1983 Mar 04; 87(4):357-65.
Partial purification of [3H]mianserin binding sites.
[3H]WIN 35,428 ([3H]CFT) binds to multiple charge-states of the solubilized dopamine transporter in primate striatum. J Pharmacol Exp Ther. 1995 Jun; 273(3):1224-34.
[3H]WIN 35,428 ([3H]CFT) binds to multiple charge-states of the solubilized dopamine transporter in primate striatum.
Bergman J, Madras BK, Johnson SE, Spealman RD
Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys. J Pharmacol Exp Ther. 1989 Oct; 251(1):150-5.
Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Tinkering with THC-to-CBD ratios in Marijuana. Neuropsychopharmacology. 2019 01; 44(1):215-216.
Tinkering with THC-to-CBD ratios in Marijuana.
Meltzer; PC, Blundell; P, Madras; BK, Fischman; AJ, Jones; AG., Mahmood; A.
Dopamine transporter imaging agents. 2003.
Madras BK, Cohen EL, Messing R, Munro HN, Wurtman RJ
Relevance of free tryptophan in serum to tissue tryptophan concentrations. Metabolism. 1974 Dec; 23(12):1107-16.
Relevance of free tryptophan in serum to tissue tryptophan concentrations.
Madras BK, Cohen EL, Munro HN, Wurtman RJ
Elevation of serum free tryptophan, but not brain tryptophan, by serum nonesterified fatty acids. Adv Biochem Psychopharmacol. 1974; 11(0):143-51.
Elevation of serum free tryptophan, but not brain tryptophan, by serum nonesterified fatty acids.
Comparison of soluble dopamine D2-receptors from three species. Eur J Pharmacol. 1982 Mar 26; 78(4):431-8.
Comparison of soluble dopamine D2-receptors from three species.
2-Carbomethoxy-3-(diarylmethoxy)-1 alpha H, 5 alpha H-tropane analogs: synthesis and inhibition of binding at the dopamine transporter and comparison with piperazines of the GBR series. J Med Chem. 1996 Jan 19; 39(2):371-9.
2-Carbomethoxy-3-(diarylmethoxy)-1 alpha H, 5 alpha H-tropane analogs: synthesis and inhibition of binding at the dopamine transporter and comparison with piperazines of the GBR series.
Horowitz B, Madras BK, Meister A, Old LJ, Boyes EA, Stockert E
Asparagine synthetase activity of mouse leukemias. Science. 1968 May 03; 160(3827):533-5.
Asparagine synthetase activity of mouse leukemias.
Bridge-substituted tropanes for methods of imaging and therapy.
Bridge-substituted tropanes for methods of imaging and therapy. 1998.
Bridge-substituted tropanes for methods of imaging and therapy
Madras BK, Cohen EL, Fernstrom JD, Larin F, Munro HN, Wurtman RJ
Letter: Dietary carbohydrate increases brain tryptophan and decreases free plasma tryptophan. Nature. 1973 Jul 06; 244(5410):34-5.
Letter: Dietary carbohydrate increases brain tryptophan and decreases free plasma tryptophan.
Pharmacological Research as a Key Component in Mitigating the Opioid Overdose Crisis. Trends Pharmacol Sci. 2018 12; 39(12):995-998.
Pharmacological Research as a Key Component in Mitigating the Opioid Overdose Crisis.
Saka E, Goodrich C, Harlan P, Madras BK, Graybiel AM
The Journal of neuroscience : the official journal of the Society for Neuroscience
Repetitive behaviors in monkeys are linked to specific striatal activation patterns. J Neurosci. 2004 Aug 25; 24(34):7557-65.
Repetitive behaviors in monkeys are linked to specific striatal activation patterns.
Anderson CM, Maas LC, Frederick Bd, Bendor JT, Spencer TJ, Livni E, Lukas SE, Fischman AJ, Madras BK, Renshaw PF, Kaufman MJ
Cerebellar vermis involvement in cocaine-related behaviors. Neuropsychopharmacology. 2006 Jun; 31(6):1318-26.
Cerebellar vermis involvement in cocaine-related behaviors.
Jassen AK, Yang H, Miller GM, Calder E, Madras BK
Receptor regulation of gene expression of axon guidance molecules: implications for adaptation. Mol Pharmacol. 2006 Jul; 70(1):71-7.
Receptor regulation of gene expression of axon guidance molecules: implications for adaptation.
Madras BK, Elmaleh DR, Meltzer PC, Liang AY, Brownell GL, Brownell AL
Positron emission tomography of cocaine binding sites on the dopamine transporter. NIDA Res Monogr. 1994; 138:57-69.
Positron emission tomography of cocaine binding sites on the dopamine transporter.
Madras BK, Reith ME, Meltzer PC, Dutta AK
O-526, a piperidine analog of GBR 12909, retains high affinity for the dopamine transporter in monkey caudate-putamen. Eur J Pharmacol. 1994 Apr 15; 267(2):167-73.
O-526, a piperidine analog of GBR 12909, retains high affinity for the dopamine transporter in monkey caudate-putamen.
The discovery of an unusually selective and novel cocaine analog: difluoropine. Synthesis and inhibition of binding at cocaine recognition sites. J Med Chem. 1994 Jun 24; 37(13):2001-10.
The discovery of an unusually selective and novel cocaine analog: difluoropine. Synthesis and inhibition of binding at cocaine recognition sites.
Spencer TJ, Madras BK, Bonab AA, Dougherty DD, Clarke A, Mirto T, Martin J, Fischman AJ
A positron emission tomography study examining the dopaminergic activity of armodafinil in adults using [¹¹C]altropane and [¹¹C]raclopride. Biol Psychiatry. 2010 Nov 15; 68(10):964-70.
A positron emission tomography study examining the dopaminergic activity of armodafinil in adults using [¹¹C]altropane and [¹¹C]raclopride.
Solubilized dopamine/neuroleptic receptors (D2-type). Prog Neuropsychopharmacol. 1981; 5(5-6):543-8.
Solubilized dopamine/neuroleptic receptors (D2-type).
Meltzer PC, Liang AY, Brownell AL, Elmaleh DR, Madras BK
Substituted 3-phenyltropane analogs of cocaine: synthesis, inhibition of binding at cocaine recognition sites, and positron emission tomography imaging. J Med Chem. 1993 Apr 02; 36(7):855-62.
Substituted 3-phenyltropane analogs of cocaine: synthesis, inhibition of binding at cocaine recognition sites, and positron emission tomography imaging.
Morris ED, Bonab AA, Alpert NM, Fischman AJ, Madras BK, Christian BT
Concentration of dopamine transporters: to Bmax or not to Bmax? Synapse. 1999 May; 32(2):136-40.
Concentration of dopamine transporters: to Bmax or not to Bmax?
Miller GM, Yatin SM, De La Garza R, Goulet M, Madras BK
Brain research. Molecular brain research
Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. Brain Res Mol Brain Res. 2001 Feb 19; 87(1):124-43.
Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity.
Meltzer PC, Wang B, Chen Z, Blundell P, Jayaraman M, Gonzalez MD, George C, Madras BK
Synthesis of 6- and 7- hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters. J Med Chem. 2001 Aug 02; 44(16):2619-35.
Synthesis of 6- and 7- hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters.
Dopamine and norepinephrine transporter-dependent c-Fos production in vitro: relevance to neuroadaptation. J Neurosci Methods. 2005 Apr 15; 143(1):69-78.
Dopamine and norepinephrine transporter-dependent c-Fos production in vitro: relevance to neuroadaptation.
Bakthavachalam V, Baindur N, Madras BK, Neumeyer JL
Fluorescent probes for dopamine receptors: synthesis and characterization of fluorescein and 7-nitrobenz-2-oxa-1,3-diazol-4-yl conjugates of D-1 and D-2 receptor ligands. J Med Chem. 1991 Nov; 34(11):3235-41.
Fluorescent probes for dopamine receptors: synthesis and characterization of fluorescein and 7-nitrobenz-2-oxa-1,3-diazol-4-yl conjugates of D-1 and D-2 receptor ligands.
Madras BK, Xie Z, Lin Z, Jassen A, Panas H, Lynch L, Johnson R, Livni E, Spencer TJ, Bonab AA, Miller GM, Fischman AJ
Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. J Pharmacol Exp Ther. 2006 Nov; 319(2):561-9.
Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro.
Pham-Huu DP, Deschamps JR, Liu S, Madras BK, Meltzer PC
Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters. Bioorg Med Chem. 2007 Jan 15; 15(2):1067-82.
Synthesis of 8-thiabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters.
Jack H. Mendelson Memorial Research Award
Meltzer, PC, Madras, BK, Blundell, P, Chen, Z.
Tropane analogs and methods for inhibition of monoamine transport. 2003.
Meltzer; Peter C; Madras; BK.; Blundell; P Chen; Z.
Tropane analogs and methods for inhibition of monoamine transport.
Okazaki MM, Madras BK, Livingston KE, Spero L, Burnham WM
Enhancement of 3H-phenytoin binding by diazepam and (+)bicuculline. Life Sci. 1983 Aug 01; 33(5):409-14.
Enhancement of 3H-phenytoin binding by diazepam and (+)bicuculline.
[3H]Mianserin binding to solubilized membranes of frontal cortex. Eur J Pharmacol. 1982 Sep 10; 83(1-2):1-10.
[3H]Mianserin binding to solubilized membranes of frontal cortex.
Dopamine Plasma Membrane Transport Proteins
Harvard T.H. Chan School of Public Health
Professor of Microbiology and Immunobiology, Emeritus
Professor of Psychology in the Department of Psychiatry, Emeritus
Associate Professor of Psychobiology in the Department of Psychiatry
Madras BK, Han B, Compton WM, Jones CM, Lopez EI, McCance-Katz EF
Associations of Parental Marijuana Use With Offspring Marijuana, Tobacco, and Alcohol Use and Opioid Misuse. JAMA Netw Open. 2019 11 01; 2(11):e1916015.
Associations of Parental Marijuana Use With Offspring Marijuana, Tobacco, and Alcohol Use and Opioid Misuse.
Psychiatry and the Opioid Overdose Crisis. Focus (Am Psychiatr Publ). 2019 Apr; 17(2):128-133.
Psychiatry and the Opioid Overdose Crisis.
Hasbi A, Madras BK, Bergman J, Kohut S, Lin Z, Withey SL, George SR
?-Tetrahydrocannabinol Increases Dopamine D1-D2 Receptor Heteromer and Elicits Phenotypic Reprogramming in Adult Primate Striatal Neurons. iScience. 2020 Jan 24; 23(1):100794.
?-Tetrahydrocannabinol Increases Dopamine D1-D2 Receptor Heteromer and Elicits Phenotypic Reprogramming in Adult Primate Striatal Neurons.
Hasbi A, Nguyen T, Rahal H, Manduca JD, Miksys S, Tyndale RF, Madras BK, Perreault ML, George SR
Sex difference in dopamine D1-D2 receptor complex expression and signaling affects depression- and anxiety-like behaviors. Biol Sex Differ. 2020 02 22; 11(1):8.
Sex difference in dopamine D1-D2 receptor complex expression and signaling affects depression- and anxiety-like behaviors.
Withey SL, Bergman J, Huestis MA, George SR, Madras BK
THC and CBD blood and brain concentrations following daily administration to adolescent primates. Drug Alcohol Depend. 2020 Aug 01; 213:108129.
THC and CBD blood and brain concentrations following daily administration to adolescent primates.
Hasbi A, Sivasubramanian M, Milenkovic M, Komarek K, Madras BK, George SR
Dopamine D1-D2 receptor heteromer expression in key brain regions of rat and higher species: Upregulation in rat striatum after cocaine administration. Neurobiol Dis. 2020 09; 143:105017.
Dopamine D1-D2 receptor heteromer expression in key brain regions of rat and higher species: Upregulation in rat striatum after cocaine administration.
Spencer TJ, Biederman J, Faraone SV, Madras BK, Bonab AA, Dougherty DD, Batchelder H, Clarke A, Fischman AJ
Functional genomics of attention-deficit/hyperactivity disorder (ADHD) risk alleles on dopamine transporter binding in ADHD and healthy control subjects. Biol Psychiatry. 2013 Jul 15; 74(2):84-9.
Functional genomics of attention-deficit/hyperactivity disorder (ADHD) risk alleles on dopamine transporter binding in ADHD and healthy control subjects.
In memoriam professor Philip Seeman (February 8, 1934-January 9, 2021). Neuropsychopharmacology. 2021 05; 46(6):1229-1230.
In memoriam professor Philip Seeman (February 8, 1934-January 9, 2021).
Withey SL, Kangas BD, Charles S, Gumbert AB, Eisold JE, George SR, Bergman J, Madras BK
Effects of daily ?9-Tetrahydrocannabinol (THC) alone or combined with cannabidiol (CBD) on cognition-based behavior and activity in adolescent nonhuman primates. Drug Alcohol Depend. 2021 04 01; 221:108629.
Effects of daily ?9-Tetrahydrocannabinol (THC) alone or combined with cannabidiol (CBD) on cognition-based behavior and activity in adolescent nonhuman primates.
Madras BK, Ahmad NJ, Wen J, Sharfstein JS
Improving Access to Evidence-Based Medical Treatment for Opioid Use Disorder: Strategies to Address Key Barriers within the Treatment System. NAM Perspect. 2020; 2020.
Improving Access to Evidence-Based Medical Treatment for Opioid Use Disorder: Strategies to Address Key Barriers within the Treatment System.
Psilocybin in Treatment-Resistant Depression. N Engl J Med. 2022 11 03; 387(18):1708-1709.
Psilocybin in Treatment-Resistant Depression.
Endocannabinoid System and Exogenous Cannabinoids in Depression and Anxiety: A Review. Brain Sci. 2023 Feb 14; 13(2).
Endocannabinoid System and Exogenous Cannabinoids in Depression and Anxiety: A Review.
Biological psychiatry global open science
Daily ?9-Tetrahydrocannabinol and Withdrawal Increase Dopamine D1-D2 Receptor Heteromer to Mediate Anhedonia- and Anxiogenic-like Behavior Through a Dynorphin and Kappa Opioid Receptor Mechanism. Biol Psychiatry Glob Open Sci. 2023 Jul; 3(3):550-566.
Daily ?9-Tetrahydrocannabinol and Withdrawal Increase Dopamine D1-D2 Receptor Heteromer to Mediate Anhedonia- and Anxiogenic-like Behavior Through a Dynorphin and Kappa Opioid Receptor Mechanism.
Di Raddo ME, Milenkovic M, Sivasubramanian M, Hasbi A, Bergman J, Withey S, Madras BK, George SR
?9-Tetrahydrocannabinol does not upregulate an aversive dopamine receptor mechanism in adolescent brain unlike in adults. Curr Res Neurobiol. 2023; 5:100107.
?9-Tetrahydrocannabinol does not upregulate an aversive dopamine receptor mechanism in adolescent brain unlike in adults.
Ament SA, Campbell RR, Lobo MK, Receveur JP, Agrawal K, Borjabad A, Byrareddy SN, Chang L, Clarke D, Emani P, Gabuzda D, Gaulton KJ, Giglio M, Giorgi FM, Gok B, Guda C, Hadas E, Herb BR, Hu W, Huttner A, Ishmam MR, Jacobs MM, Kelschenbach J, Kim DW, Lee C, Liu S, Liu X, Madras BK, Mahurkar AA, Mash DC, Mukamel EA, Niu M, O'Connor RM, Pagan CM, Pang APS, Pillai P, Repunte-Canonigo V, Ruzicka WB, Stanley J, Tickle T, Tsai SA, Wang A, Wills L, Wilson AM, Wright SN, Xu S, Yang J, Zand M, Zhang L, Zhang J, Akbarian S, Buch S, Cheng CS, Corley MJ, Fox HS, Gerstein M, Gummuluru S, Heiman M, Ho YC, Kellis M, Kenny PJ, Kluger Y, Milner TA, Moore DJ, Morgello S, Ndhlovu LC, Rana TM, Sanna PP, Satterlee JS, Sestan N, Spector SA, Spudich S, Tilgner HU, Volsky DJ, White OR, Williams DW, Zeng H
The single-cell opioid responses in the context of HIV (SCORCH) consortium. Mol Psychiatry. 2024 Dec; 29(12):3950-3961.
The single-cell opioid responses in the context of HIV (SCORCH) consortium.
Katz NP, Birnbaum H, Brennan MJ, Freedman JD, Gilmore GP, Jay D, Kenna GA, Madras BK, McElhaney L, Weiss RD, White AG
Prescription opioid abuse: challenges and opportunities for payers. Am J Manag Care. 2013 Apr; 19(4):295-302.
Prescription opioid abuse: challenges and opportunities for payers.
American Academy of Sciences and Letters (AASL)
Executive Office of the President of the United States
President’s Commission on Combating Drug Addiction and the Opioid Crisis
Deputy Director, White House Office of National Drug Control Policy ONDCP
asteroid 147703 MADRAS = 2005 GU203 minor planet (named for Bertha Madras)
American Academy Physical Medicine Rehabilitation
Louisiana State University School of Medicine
Bi-national U.S. Mexico Demand Reduction
American Academy of Addiction Psychiatry
Association of University Technology Managers (AUTM)
Technology Transfer Innovations that Changed the World
National Institute on Drug Abuse (NIDA-NIH)
Panelist, the Vatican Pontifical Academy of Sciences
Chair, White House National Leadership Conferences (3) Medical Education in Substance Abuse
United Nations Office on Drugs and Crime
Expert Committee on Drug Dependence, Policy, Access and Use Essential Medicines and Health Product
Chair, Ontario Mental Health Foundation, Fellowships and Awards Committee
Member, National Academy of Medicine Action Collaborative on Countering the U.S. Opioid Epidemic
DrugFree Singapore Champions Conference 2025
DrugFree Singapore Champions Conference 2025 U. of Rochester Medical Center Psychiatry Grand Rounds
DrugFree Singapore Champions Conference 2025 U. of Rochester Medical Center Psychiatry Grand Rounds Sagely Speaking with Mary Bono
WHO Report: The Health and social effects of nonmedical cannabis use:. World Health Organization. 2016.
WHO Report: The Health and social effects of nonmedical cannabis use:
Meltzer PC, Madras BK, Blundell P, Chen Z
Blundell, Paul, Meltzer, Peter C., Madras, Bertha K.
Madras; Bertha K. Fischman; Alan J., Meltzer; Peter C.
Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level.
Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level. 2009.
Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level
Lajtha A, ed. Handbook of Neurochemistry. New York; Plenum Press,. Dopamine. 1984; 6:71-106.
Lajtha A, ed. Handbook of Neurochemistry. New York; Plenum Press,
Cannabis and Medicine: An Evidence-based Approach.Kenneth Finn, MD, editor. Cannabinoid and Marijuana Neurobiology. 2020; 25-47.
Cannabis and Medicine: An Evidence-based Approach.Kenneth Finn, MD, editor
What You Aren’t Hearing About Marijuana’s Health Effects: Weekend Interview with Bertha K. Madras.
Wall Street Journal (New York). What You Aren’t Hearing About Marijuana’s Health Effects: Weekend Interview with Bertha K. Madras. 2024.
Governor Chris Christie (Chairman), Governor Charlies Baker (MA); Florida Attorney General Pam Bondi; Governor Roy Cooper (NC); Professor Bertha Madras, PhD, Congressman Patrick Kennedy (RI, retired).
The President’s Commission on Combating Drug Addiction and the Opioid Crisis: final report. White House Report. 2017.
The President’s Commission on Combating Drug Addiction and the Opioid Crisis: final report
6.2 Update of Cannabis and its Medical Use, 2015 (WHO)
6.2 Update of Cannabis and its Medical Use, 2015 (WHO). 2016.
Multiple authors (BK Madras and Chancellor Bishop Marcelo Sorondo final edits)
Summary Statement; The Global Problem of Narcotics and Solutions. Vatican Pontifical Academy of Sciences,
Summary Statement; The Global Problem of Narcotics and Solutions. Vatican Pontifical Academy of Sciences,. 2016.
Sun Y, Sivasubramanian M, Milenkovic M, Gumbert A, Bergman J, Ge P, Heiman M, Di Raddo ME, Withey SL, Madras BK, George SR. 2025 Mar 29;5(4):100496. doi: 10.1016/j.bpsgos.2025.100496.
Astrogliosis Occurs Selectively in Amygdala of Adolescent Primate and Rodent Following Daily ?9-Tetrahydrocannabinol, Prevented by Cannabidiol Co-Treatment. Biol Psychiatry Glob Open Sci. 2025; 5(4):100496. .
Astrogliosis Occurs Selectively in Amygdala of Adolescent Primate and Rodent Following Daily ?9-Tetrahydrocannabinol, Prevented by Cannabidiol Co-Treatment
C Lerman, JJ Gonzales, E Howell, TA Kirk Jr, BK Madras, AT McLellan, C Weisner, with Federal Council Workgroup Staff, M Hiremath, T Levitin, R Katt.
Adoption of NIDA’s Evidence-Based Treatments in Real World Settings: A National Advisory Council on Drug Abuse Workgroup Report.
Adoption of NIDA’s Evidence-Based Treatments in Real World Settings: A National Advisory Council on Drug Abuse Workgroup Report. 2011.
Adoption of NIDA’s Evidence-Based Treatments in Real World Settings: A National Advisory Council on Drug Abuse Workgroup Report
Elmaleh DE, Madras BK, Meltzer PC, Hanson RN. Substituted 2 carboxyalkyl 3(fluorophenyl) 8 (3 halopropen 2 yl) nortropanes and their use as imaging agents for neurodegenerative disorders.
Methods for diagnosing and monitoring treatment ADHD by assessing the dopamine transporter level. 2006.
Fernstrom JD, Madras BK, Munro HN, Wurtman RJ.
Nutritional control of the synthesis of 5-hydroxytryptamine in the brain. Aromatic amino acids in the brain.
Amsterdam; ASP Elsevier 1. Nutritional control of the synthesis of 5-hydroxytryptamine in the brain. Aromatic amino acids in the brain. 1974; 153-173.
Adv. Biochem Psychopharmacology 1983; 37:. Modulation of dopamine receptor binding by ascorbic acid. 1983; 37:275-287.
Adv. Biochem Psychopharmacology 1983; 37:
The Drug Crisis Hasn’t Gone Away. The Trump Administration Should Confront It.
National Review,. The Drug Crisis Hasn’t Gone Away. The Trump Administration Should Confront It. 2025.
Paul J. Larkin, Jr., Robert L. DuPont, Bertha K. Madras. The Need to Treat Driving Under the Influence of Drugs as Seriously as Driving Under the Influence of Alcohol. Backgrounder, The Heritage Foundation. 3316, May 16, 2018.
The Need to Treat Driving Under the Influence of Drugs as Seriously as Driving Under the Influence of Alcohol. Backgrounder, The Heritage Foundation. 2018; 3316.
The Need to Treat Driving Under the Influence of Drugs as Seriously as Driving Under the Influence of Alcohol
Meltzer PC, Madras BK Blundell P Chen Z.
Tropane analogs and methods for inhibition of dopamine transport,
Tropane analogs and methods for inhibition of dopamine transport,. 1999.
Lin Z and Madras BK in Handbook of Experimental Pharmacology,
Human Genetics of Neurotransmitter Transporters,
Neurotransmitters Transporters M Freissmuth and H Sitte, editors. Human Genetics of Neurotransmitter Transporters,. 2006; 175:327-371.
Neurotransmitters Transporters M Freissmuth and H Sitte, editors
Meltzer PC, Blundell P, Madras BK, Fischman AJ, Jones AG., Mahmood A.
Meltzer, Peter C. Madras, Bertha K. Blundell, Paul, Liu, Shanghao.
Imaging the dopamine transporter: a window on dopamine neurons. Advances in Neurodegenerative disorders.
J. Marwah and H. Teitelbaum, eds. Vol. 1 Parkinson’s disease, Prominent Press, Scottsdale, AZ. Imaging the dopamine transporter: a window on dopamine neurons. Advances in Neurodegenerative disorders. 1998; 229- 253. .
J. Marwah and H. Teitelbaum, eds. Vol. 1 Parkinson’s disease, Prominent Press, Scottsdale, AZ
“Neuropharmacology of New Psychoactive Substances”, M Baumann Editor, in series “Current Topics in Behavioral Neurosciences (CTBN)”, Mark A. Geyer, Charles A. Marsden, Bart A. Ellenbroek, Thomas R.E. Barnes (Eds.). Introduction. 2016; 32:1-18.
“Neuropharmacology of New Psychoactive Substances”, M Baumann Editor, in series “Current Topics in Behavioral Neurosciences (CTBN)”, Mark A. Geyer, Charles A. Marsden, Bart A. Ellenbroek, Thomas R.E. Barnes (Eds.)
Elmaleh DE, Madras BK, Hanson R, Meltzer PC
Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl)nortropanes and their use as imaging agents for neurodegenerative disorders.
Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl)nortropanes and their use as imaging agents for neurodegenerative disorders. 1996.
Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl)nortropanes and their use as imaging agents for neurodegenerative disorders
Meltzer PC, Madras BK, Davison A, Blundell P, Mahmood A, Jones AG.
Dopamine transporter imaging agent. 2001.
Meltzer; PC. Madras; BK.; Blundell; P; Chen; Z.
Meltzer; Peter C. Blundell; Paul Wang; Pinglang Madras; Bertha K.
Compounds with high monoamine transporter affinity
Compounds with high monoamine transporter affinity. 2006.
Meltzer, Peter C, Blundell, Paul, Madras, Bertha K.
Meltzer, Peter C., Madras; Bertha K., Blundell; Paul.
Tropane analogs and methods for inhibition of monoamine transport. 2007.
Madras BK, Davis A, Kunashko P, Seeman P.
Solubilization of dopamine receptors from dog and human brains.
In; Yamamura HI, Olsen RW, Usdin E, eds. Psychopharmacology and Biochemistry of Neurotransmitter receptors. North Holland; Elsevier 1980;. Solubilization of dopamine receptors from dog and human brains. 1980; 411-419.
In; Yamamura HI, Olsen RW, Usdin E, eds. Psychopharmacology and Biochemistry of Neurotransmitter receptors. North Holland; Elsevier 1980;
Direct binding assays in determining psychotropic drug mechanism of action.
Revs in Pure and Applied Pharmacol. Sci. Direct binding assays in determining psychotropic drug mechanism of action. 1983; 4:271-338.
Chapter One - Drug Use and Its Consequences,
The Effects of Drug Abuse on the Human Nervous System, Editor(s): Bertha Madras, Michael Kuhar,. Chapter One - Drug Use and Its Consequences,. 2014; 1-35.
The Effects of Drug Abuse on the Human Nervous System, Editor(s): Bertha Madras, Michael Kuhar,
Tropane analogs and methods for inhibition of monoamine transport,
Tropane analogs and methods for inhibition of monoamine transport,. 2002.
Genetic variation and phenotype associations common to rhesus monkeys and humans,
The Laboratory Primate, Sonia Wolfe-Coote editor,. Genetic variation and phenotype associations common to rhesus monkeys and humans,. 2005; 17-26.
The Laboratory Primate, Sonia Wolfe-Coote editor,
Rescheduling Cannabis-Medicine or Politics?. JAMA Psychiatry. 2025; 82(9):934-939.
Rescheduling Cannabis-Medicine or Politics?
Georgetown Journal of Law & Public Policy
Opioids, Overdoses, and Cannabis: Is Marijuana an Effective Therapeutic Response to the Opioid Abuse Epidemic?. Georgetown Journal of Law & Public Policy. 2019; 17(2):555-597.
Opioids, Overdoses, and Cannabis: Is Marijuana an Effective Therapeutic Response to the Opioid Abuse Epidemic?
Madras BK, Colvis CM, Pollack JD, Rutter JL, Shurtleff D, von Zastrow M, Editors, Cold
American Psychological Association Addiction Syndrome Handbook, HJ Shaffer, Ed. Unique Consequences of Addiction”. 2012.
American Psychological Association Addiction Syndrome Handbook, HJ Shaffer, Ed
Robert L. DuPont, Bertha K. Madras, Per Johansson.
Drug policy: A biological science perspective.
Section 12: Policy Issues, Chapter 77, In J. H. Lowinson & P. Ruiz (Eds.) Substance Abuse: A Comprehensive Textbook. Drug policy: A biological science perspective. 2011.
Section 12: Policy Issues, Chapter 77, In J. H. Lowinson & P. Ruiz (Eds.) Substance Abuse: A Comprehensive Textbook
New faculty-led organization at Harvard will defend academic freedom
Boston Globe. New faculty-led organization at Harvard will defend academic freedom. 2023.
Rescheduling Cannabis-Medicine or Politics? JAMA Psychiatry. 2025 Sep 01; 82(9):934-939.
Sun Y, Sivasubramanian M, Milenkovic M, Gumbert A, Bergman J, Ge P, Heiman M, Di Raddo ME, Withey SL, Madras BK, George SR
Astrogliosis Occurs Selectively in Amygdala of Adolescent Primate and Rodent Following Daily ?9-Tetrahydrocannabinol, Prevented by Cannabidiol Co-Treatment. Biol Psychiatry Glob Open Sci. 2025 Jul; 5(4):100496.
Astrogliosis Occurs Selectively in Amygdala of Adolescent Primate and Rodent Following Daily ?9-Tetrahydrocannabinol, Prevented by Cannabidiol Co-Treatment.
Faraone SV, Spencer TJ, Madras BK, Zhang-James Y, Biederman J
Functional effects of dopamine transporter gene genotypes on in vivo dopamine transporter functioning: a meta-analysis. Mol Psychiatry. 2014 Aug; 19(8):880-9.
Functional effects of dopamine transporter gene genotypes on in vivo dopamine transporter functioning: a meta-analysis.
Proceedings of the National Academy of Sciences of the United States of America
Dopamine challenge reveals neuroadaptive changes in marijuana abusers. Proc Natl Acad Sci U S A. 2014 Aug 19; 111(33):11915-6.
Dopamine challenge reveals neuroadaptive changes in marijuana abusers.
Response to Selveraj et al. Mol Psychiatry. 2014 Sep; 19(9):964-5.
Vesicular monoamine transporter 2 loss in human cocaine abusers confirmed in nonhuman primate brain. Biol Psychiatry. 2015 Mar 01; 77(5):421-2.
Vesicular monoamine transporter 2 loss in human cocaine abusers confirmed in nonhuman primate brain.
Are THC Levels in Oral Fluids and Blood Plasma Comparable after Oral Ingestion of Edibles Containing Cannabis or THC? Clin Chem. 2017 03; 63(3):629-631.
Are THC Levels in Oral Fluids and Blood Plasma Comparable after Oral Ingestion of Edibles Containing Cannabis or THC?
Brownell AL, Elmaleh DR, Meltzer PC, Shoup TM, Brownell GL, Fischman AJ, Madras BK
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Cocaine congeners as PET imaging probes for dopamine terminals. J Nucl Med. 1996 Jul; 37(7):1186-92.
Cocaine congeners as PET imaging probes for dopamine terminals.
Elmaleh DR, Fischman AJ, Shoup TM, Byon C, Hanson RN, Liang AY, Meltzer PC, Madras BK
Preparation and biological evaluation of iodine-125-IACFT: a selective SPECT agent for imaging dopamine transporter sites. J Nucl Med. 1996 Jul; 37(7):1197-202.
Preparation and biological evaluation of iodine-125-IACFT: a selective SPECT agent for imaging dopamine transporter sites.
Morris ED, Babich JW, Alpert NM, Bonab AA, Livni E, Weise S, Hsu H, Christian BT, Madras BK, Fischman AJ
Quantification of dopamine transporter density in monkeys by dynamic PET imaging of multiple injections of 11C-CFT. Synapse. 1996 Nov; 24(3):262-72.
Quantification of dopamine transporter density in monkeys by dynamic PET imaging of multiple injections of 11C-CFT.
Miller GM, De La Garza R, Novak MA, Madras BK
Single nucleotide polymorphisms distinguish multiple dopamine transporter alleles in primates: implications for association with attention deficit hyperactivity disorder and other neuropsychiatric disorders. Mol Psychiatry. 2001 Jan; 6(1):50-8.
Single nucleotide polymorphisms distinguish multiple dopamine transporter alleles in primates: implications for association with attention deficit hyperactivity disorder and other neuropsychiatric disorders.
Miller GM, Verrico CD, Jassen A, Konar M, Yang H, Panas H, Bahn M, Johnson R, Madras BK
Primate trace amine receptor 1 modulation by the dopamine transporter. J Pharmacol Exp Ther. 2005 Jun; 313(3):983-94.
Primate trace amine receptor 1 modulation by the dopamine transporter.
The dopamine transporter and attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005 Jun 01; 57(11):1397-409.
The dopamine transporter and attention-deficit/hyperactivity disorder.
Meltzer PC, Liang AY, Blundell P, Gonzalez MD, Chen Z, George C, Madras BK
2-Carbomethoxy-3-aryl-8-oxabicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters. J Med Chem. 1997 Aug 15; 40(17):2661-73.
2-Carbomethoxy-3-aryl-8-oxabicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters.
Madras BK, Gracz LM, Meltzer PC, Liang AY, Elmaleh DR, Kaufman MJ, Fischman AJ
Altropane, a SPECT or PET imaging probe for dopamine neurons: II. Distribution to dopamine-rich regions of primate brain. Synapse. 1998 Jun; 29(2):105-15.
Altropane, a SPECT or PET imaging probe for dopamine neurons: II. Distribution to dopamine-rich regions of primate brain.
Hantraye P, Brownell AL, Elmaleh D, Spealman RD, Wüllner U, Brownell GL, Madras BK, Isacson O
Dopamine fiber detection by [11C]-CFT and PET in a primate model of parkinsonism. Neuroreport. 1992 Mar; 3(3):265-8.
Dopamine fiber detection by [11C]-CFT and PET in a primate model of parkinsonism.
Current topics in behavioral neurosciences
The Growing Problem of New Psychoactive Substances (NPS). Curr Top Behav Neurosci. 2017; 32:1-18.
The Growing Problem of New Psychoactive Substances (NPS).
Madras BK, Jones AG, Mahmood A, Zimmerman RE, Garada B, Holman BL, Davison A, Blundell P, Meltzer PC
Technepine: a high-affinity 99m-technetium probe to label the dopamine transporter in brain by SPECT imaging. Synapse. 1996 Mar; 22(3):239-46.
Technepine: a high-affinity 99m-technetium probe to label the dopamine transporter in brain by SPECT imaging.
Dougherty DD, Bonab AA, Spencer TJ, Rauch SL, Madras BK, Fischman AJ
Dopamine transporter density in patients with attention deficit hyperactivity disorder. Lancet. 1999 Dec 18-25; 354(9196):2132-3.
Dopamine transporter density in patients with attention deficit hyperactivity disorder.
The Surge of Opioid Use, Addiction, and Overdoses: Responsibility and Response of the US Health Care System. JAMA Psychiatry. 2017 05 01; 74(5):441-442.
The Surge of Opioid Use, Addiction, and Overdoses: Responsibility and Response of the US Health Care System.
Meltzer PC, Blundell P, Yong YF, Chen Z, George C, Gonzalez MD, Madras BK
2-Carbomethoxy-3-aryl-8-bicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters. J Med Chem. 2000 Aug 10; 43(16):2982-91.
2-Carbomethoxy-3-aryl-8-bicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters.
Fischman AJ, Bonab AA, Babich JW, Livni E, Alpert NM, Meltzer PC, Madras BK
[(11)C, (127)I] Altropane: a highly selective ligand for PET imaging of dopamine transporter sites. Synapse. 2001 Mar 15; 39(4):332-42.
[(11)C, (127)I] Altropane: a highly selective ligand for PET imaging of dopamine transporter sites.
Meltzer PC, Blundell P, Zona T, Yang L, Huang H, Bonab AA, Livni E, Fischman A, Madras BK
A second-generation 99m technetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain. J Med Chem. 2003 Jul 31; 46(16):3483-96.
A second-generation 99m technetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain.
The neurobiology of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005 Jun 01; 57(11):1374-6.
The neurobiology of attention-deficit/hyperactivity disorder.
Milius RA, Saha JK, Madras BK, Neumeyer JL
Synthesis and receptor binding of N-substituted tropane derivatives. High-affinity ligands for the cocaine receptor. J Med Chem. 1991 May; 34(5):1728-31.
Synthesis and receptor binding of N-substituted tropane derivatives. High-affinity ligands for the cocaine receptor.
Bergman J, Spealman RD, Madras BK, Rosenzweig-Lipson S
Agonist efficacy and the behavioral effects of dopamine D1 receptor ligands: drug interaction studies in squirrel monkeys. J Pharmacol Exp Ther. 1996 Mar; 276(3):942-50.
Agonist efficacy and the behavioral effects of dopamine D1 receptor ligands: drug interaction studies in squirrel monkeys.
Polymorphisms in the 3'-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression. Mol Psychiatry. 2002; 7(1):44-55.
Polymorphisms in the 3'-untranslated region of human and monkey dopamine transporter genes affect reporter gene expression.
Elmaleh DE, Madras BK, Meltzer PC, Hanson RN.
Substituted 2 carboxyalkyl 3(fluorophenyl) 8 (3 halopropen 2 yl) nortropanes and their use as imaging agents for neurodegenerative disorders
Substituted 2 carboxyalkyl 3(fluorophenyl) 8 (3 halopropen 2 yl) nortropanes and their use as imaging agents for neurodegenerative disorders. 1998.
The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD). Behav Brain Res. 2002 Mar 10; 130(1-2):57-63.
The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD).
Spencer TJ, Biederman J, Madras BK, Faraone SV, Dougherty DD, Bonab AA, Fischman AJ
In vivo neuroreceptor imaging in attention-deficit/hyperactivity disorder: a focus on the dopamine transporter. Biol Psychiatry. 2005 Jun 01; 57(11):1293-300.
In vivo neuroreceptor imaging in attention-deficit/hyperactivity disorder: a focus on the dopamine transporter.
Fischman AJ, Bonab AA, Babich JW, Palmer EP, Alpert NM, Elmaleh DR, Callahan RJ, Barrow SA, Graham W, Meltzer PC, Hanson RN, Madras BK
Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters. Synapse. 1998 Jun; 29(2):128-41.
Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters.
Spealman RD, Bergman J, Madras BK, Melia KF
Discriminative stimulus effects of cocaine in squirrel monkeys: involvement of dopamine receptor subtypes. J Pharmacol Exp Ther. 1991 Sep; 258(3):945-53.
Discriminative stimulus effects of cocaine in squirrel monkeys: involvement of dopamine receptor subtypes.
Pharmacology, biochemistry, and behavior
Self-administration of the high-affinity cocaine analog 2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane. Pharmacol Biochem Behav. 1991 Aug; 39(4):1011-3.
Self-administration of the high-affinity cocaine analog 2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane.
Meltzer PC, Blundell P, Jones AG, Mahmood A, Garada B, Zimmerman RE, Davison A, Holman BL, Madras BK
A technetium-99m SPECT imaging agent which targets the dopamine transporter in primate brain. J Med Chem. 1997 Jun 06; 40(12):1835-44.
A technetium-99m SPECT imaging agent which targets the dopamine transporter in primate brain.
Neumeyer JL, Baindur N, Bakthavachalam V, Yuan J, Madras BK, Kula NS, Campbell A, Baldessarini RJ
Alan Horn Memorial Lecture. Selective probes for characterization of dopamine D1 and D2 receptors. Neurochem Int. 1992 Mar; 20 Suppl:63S-68S.
Alan Horn Memorial Lecture. Selective probes for characterization of dopamine D1 and D2 receptors.
Madras BK, Fahey MA, Miller GM, De La Garza R, Goulet M, Spealman RD, Meltzer PC, George SR, O'Dowd BF, Bonab AA, Livni E, Fischman AJ
Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors. Eur J Pharmacol. 2003 Oct 31; 479(1-3):41-51.
Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors.
Behavioral effects of D1 and D2 dopamine receptor antagonists in squirrel monkeys. J Pharmacol Exp Ther. 1991 Sep; 258(3):910-7.
Behavioral effects of D1 and D2 dopamine receptor antagonists in squirrel monkeys.
Distribution of cocaine recognition sites in monkey brain: II. Ex vivo autoradiography with [3H]CFT and [125I]RTI-55. Synapse. 1992 Oct; 12(2):99-111.
Distribution of cocaine recognition sites in monkey brain: II. Ex vivo autoradiography with [3H]CFT and [125I]RTI-55.
D(1) dopamine receptor agonists are more effective in alleviating advanced than mild parkinsonism in 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated monkeys. J Pharmacol Exp Ther. 2000 Feb; 292(2):714-24.
D(1) dopamine receptor agonists are more effective in alleviating advanced than mild parkinsonism in 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated monkeys.
Synthesis and biological activity of 2-carbomethoxy-3-catechol-8-azabicyclo[3.2.1]octanes. Bioorg Med Chem Lett. 2003 Nov 17; 13(22):4133-7.
Synthesis and biological activity of 2-carbomethoxy-3-catechol-8-azabicyclo[3.2.1]octanes.
Miller GM, Bendor J, Tiefenbacher S, Yang H, Novak MA, Madras BK
A mu-opioid receptor single nucleotide polymorphism in rhesus monkey: association with stress response and aggression. Mol Psychiatry. 2004 Jan; 9(1):99-108.
A mu-opioid receptor single nucleotide polymorphism in rhesus monkey: association with stress response and aggression.
Meltzer; PC. Blundell; P, Wang; P; Madras; BK
Compounds with high monoamine transporter affinity.
Compounds with high monoamine transporter affinity. 2003.
Drug potencies on partially purified brain D2 dopamine receptors. J Neurochem. 1985 Mar; 44(3):856-61.
Drug potencies on partially purified brain D2 dopamine receptors.
Annals of the New York Academy of Sciences
Office of National Drug Control Policy: a scientist in drug policy in Washington, DC. Ann N Y Acad Sci. 2010 Feb; 1187:370-402.
Office of National Drug Control Policy: a scientist in drug policy in Washington, DC.
Solubilized receptors for [3H]dopamine (D3 binding sites) from canine brain. Biochem Pharmacol. 1982 Apr 01; 31(7):1183-7.
Solubilized receptors for [3H]dopamine (D3 binding sites) from canine brain.
Madras BK, Canfield DR, Pfaelzer C, Vittimberga FJ, Difiglia M, Aronin N, Bakthavachalam V, Baindur N, Neumeyer JL
Fluorescent and biotin probes for dopamine receptors: D1 and D2 receptor affinity and selectivity. Mol Pharmacol. 1990 Jun; 37(6):833-9.
Fluorescent and biotin probes for dopamine receptors: D1 and D2 receptor affinity and selectivity.
Schumacher JM, Hantraye P, Brownell AL, Riche D, Madras BK, Davenport PD, Maziere M, Elmaleh DR, Brownell GL, Isacson O
A primate model of Huntington's disease: functional neural transplantation and CT-guided stereotactic procedures. Cell Transplant. 1992; 1(4):313-22.
A primate model of Huntington's disease: functional neural transplantation and CT-guided stereotactic procedures.
Madras BK, Pristupa ZB, Niznik HB, Liang AY, Blundell P, Gonzalez MD, Meltzer PC
Nitrogen-based drugs are not essential for blockade of monoamine transporters. Synapse. 1996 Dec; 24(4):340-8.
Nitrogen-based drugs are not essential for blockade of monoamine transporters.
Synthesis and structure-activity relationship studies of 3-biaryl-8-oxabicyclo[3.2.1]octane-2-carboxylic acid methyl esters. Bioorg Med Chem. 2012 Apr 15; 20(8):2762-72.
Synthesis and structure-activity relationship studies of 3-biaryl-8-oxabicyclo[3.2.1]octane-2-carboxylic acid methyl esters.
Spencer TJ, Madras BK, Fischman AJ, Krause J, La Fougère C
Striatal dopamine transporter binding in adults with ADHD. Am J Psychiatry. 2012 Jun; 169(6):665; author reply 666.
Striatal dopamine transporter binding in adults with ADHD.
South Dakota medicine : the journal of the South Dakota State Medical Association
Cannabis and Medicinal Properties. S D Med. 2016 Spec; No:34-45.
Ineffective Policies to Address the Opioid Epidemic-Reply. JAMA Psychiatry. 2017 09 01; 74(9):974-975.
Ineffective Policies to Address the Opioid Epidemic-Reply.
Effects of drugs on the metabolism of tryptophan. Alpha-hydrazinotryptophan and other amino acid analogs. Biochem Pharmacol. 1968 Jun; 17(6):1037-47.
Effects of drugs on the metabolism of tryptophan. Alpha-hydrazinotryptophan and other amino acid analogs.
Solubilization of neuroleptic/dopamine receptors of human brain striatum. Eur J Pharmacol. 1981 Mar 26; 70(3):321-9.
Solubilization of neuroleptic/dopamine receptors of human brain striatum.
Jassen AK, Brown JM, Panas HN, Miller GM, Xiao D, Madras BK
Variants of the primate vesicular monoamine transporter-2. Brain Res Mol Brain Res. 2005 Oct 03; 139(2):251-7.
Variants of the primate vesicular monoamine transporter-2.
Meltzer PC, Wang P, Blundell P, Madras BK
Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate. J Med Chem. 2003 Apr 10; 46(8):1538-45.
Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate.
MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment. Psychopharmacology (Berl). 2007 Jan; 189(4):489-503.
MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment.
Dep of Psychiatry, Mailman Research Center #315
Spealman RD, Bergman J, Madras BK, Kamien JB, Melia KF
Role of D1 and D2 dopamine receptors in the behavioral effects of cocaine. Neurochem Int. 1992 Mar; 20 Suppl:147S-152S.
Role of D1 and D2 dopamine receptors in the behavioral effects of cocaine.
Madras BK, Fahey MA, Canfield DR, Spealman RD
D1 and D2 dopamine receptors in caudate-putamen of nonhuman primates (Macaca fascicularis). J Neurochem. 1988 Sep; 51(3):934-43.
D1 and D2 dopamine receptors in caudate-putamen of nonhuman primates (Macaca fascicularis).
Reviews in pure & applied pharmacological sciences
Direct binding assays in determining psychotropic drug mechanism of action. Rev Pure Appl Pharmacol Sci. 1983 Jul-Sep; 4(3):271-338.
Yatin SM, Miller GM, Norton C, Madras BK
Dopamine transporter-dependent induction of C-Fos in HEK cells. Synapse. 2002 Jul; 45(1):52-65.
Dopamine transporter-dependent induction of C-Fos in HEK cells.
Zhdanova IV, Geiger DA, Schwagerl AL, Leclair OU, Killiany R, Taylor JA, Rosene DL, Moss MB, Madras BK
Melatonin promotes sleep in three species of diurnal nonhuman primates. Physiol Behav. 2002 Apr 01; 75(4):523-9.
Melatonin promotes sleep in three species of diurnal nonhuman primates.
Meschler JP, Clarkson FA, Mathews PJ, Howlett AC, Madras BK
D(2), but not D(1) dopamine receptor agonists potentiate cannabinoid-induced sedation in nonhuman primates. J Pharmacol Exp Ther. 2000 Mar; 292(3):952-9.
D(2), but not D(1) dopamine receptor agonists potentiate cannabinoid-induced sedation in nonhuman primates.
[(3)H]PNU-101958, a D(4) dopamine receptor probe, accumulates in prefrontal cortex and hippocampus of non-human primate brain. Synapse. 2000 Sep 01; 37(3):232-44.
[(3)H]PNU-101958, a D(4) dopamine receptor probe, accumulates in prefrontal cortex and hippocampus of non-human primate brain.
Meltzer PC, Liu S, Blanchette H, Blundell P, Madras BK
Design and synthesis of an irreversible dopamine-sparing cocaine antagonist. Bioorg Med Chem. 2002 Nov; 10(11):3583-91.
Design and synthesis of an irreversible dopamine-sparing cocaine antagonist.
Synthesis of 8-thiabicyclo[3.2.1]oct-2-enes and their binding affinity for the dopamine and serotonin transporters. Bioorg Med Chem Lett. 2004 Dec 20; 14(24):6007-10.
Synthesis of 8-thiabicyclo[3.2.1]oct-2-enes and their binding affinity for the dopamine and serotonin transporters.
Meltzer PC, Butler D, Deschamps JR, Madras BK
1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors. J Med Chem. 2006 Feb 23; 49(4):1420-32.
1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors.
Canfield DR, Spealman RD, Kaufman MJ, Madras BK
Autoradiographic localization of cocaine binding sites by [3H]CFT ([3H]WIN 35,428) in the monkey brain. Synapse. 1990; 6(2):189-95.
Autoradiographic localization of cocaine binding sites by [3H]CFT ([3H]WIN 35,428) in the monkey brain.
Brownell AL, Hantraye P, Wullner U, Hamberg L, Shoup T, Elmaleh DR, Frim DM, Madras BK, Brownell GL, Rosen BR
PET- and MRI-based assessment of glucose utilization, dopamine receptor binding, and hemodynamic changes after lesions to the caudate-putamen in primates. Exp Neurol. 1994 Jan; 125(1):41-51.
PET- and MRI-based assessment of glucose utilization, dopamine receptor binding, and hemodynamic changes after lesions to the caudate-putamen in primates.
Madras BK, Kamien JB, Fahey MA, Canfield DR, Milius RA, Saha JK, Neumeyer JL, Spealman RD
N-modified fluorophenyltropane analogs of cocaine with high affinity for cocaine receptors. Pharmacol Biochem Behav. 1990 Apr; 35(4):949-53.
N-modified fluorophenyltropane analogs of cocaine with high affinity for cocaine receptors.
Madras BK, Miller GM, Meltzer PC, Brownell AL, Fischman AJ
Molecular and regional targets of cocaine in primate brain: liberation from prosaic views. Addict Biol. 2000 Jul 01; 5(3):351-9.
Molecular and regional targets of cocaine in primate brain: liberation from prosaic views.
Journal of the history of the neurosciences
History of the discovery of the antipsychotic dopamine D2 receptor: a basis for the dopamine hypothesis of schizophrenia. J Hist Neurosci. 2013; 22(1):62-78.
History of the discovery of the antipsychotic dopamine D2 receptor: a basis for the dopamine hypothesis of schizophrenia.
Lipsett D, Madras BK, Wurtman RJ, Munro HN
Life sciences. Pt. 2: Biochemistry, general and molecular biology
Serum tryptophan level after carbohydrate ingestion: selective decline in non-albumin-bound tryptophan coincident with reduction in serum free fatty acids. Life Sci II. 1973 Jan 22; 12(2):57-64.
Serum tryptophan level after carbohydrate ingestion: selective decline in non-albumin-bound tryptophan coincident with reduction in serum free fatty acids.
Formation of respiratory 14CO2 from variously labeled forms of tryptophan-14C in intact and adrenalectomized rats. Arch Biochem Biophys. 1968 Jun; 125(3):829-36.
Formation of respiratory 14CO2 from variously labeled forms of tryptophan-14C in intact and adrenalectomized rats.
Burnham WM, Spero L, Okazaki MM, Madras BK
Canadian journal of physiology and pharmacology
Saturable binding of [3H]phenytoin to rat brain membrane fraction. Can J Physiol Pharmacol. 1981 Apr; 59(4):402-7.
Saturable binding of [3H]phenytoin to rat brain membrane fraction.
Assay for soluble dopamine receptors by the precipitation method. Eur J Pharmacol. 1981 Aug 27; 74(1):53-9.
Assay for soluble dopamine receptors by the precipitation method.
Cocaine accumulates in dopamine-rich regions of primate brain after i.v. administration: comparison with mazindol distribution. Synapse. 1994 Nov; 18(3):261-75.
Cocaine accumulates in dopamine-rich regions of primate brain after i.v. administration: comparison with mazindol distribution.
Verrico CD, Lynch L, Fahey MA, Fryer AK, Miller GM, Madras BK
Journal of psychopharmacology (Oxford, England)
MDMA-induced impairment in primates: antagonism by a selective norepinephrine or serotonin, but not by a dopamine/norepinephrine transport inhibitor. J Psychopharmacol. 2008 Mar; 22(2):187-202.
MDMA-induced impairment in primates: antagonism by a selective norepinephrine or serotonin, but not by a dopamine/norepinephrine transport inhibitor.
Anti-hyperactivity medication: methylphenidate and amphetamine. Mol Psychiatry. 1998 Sep; 3(5):386-96.
Anti-hyperactivity medication: methylphenidate and amphetamine.
Madras BK, Meltzer PC, Liang AY, Elmaleh DR, Babich J, Fischman AJ
Altropane, a SPECT or PET imaging probe for dopamine neurons: I. Dopamine transporter binding in primate brain. Synapse. 1998 Jun; 29(2):93-104.
Altropane, a SPECT or PET imaging probe for dopamine neurons: I. Dopamine transporter binding in primate brain.
Fischman AJ, Babich JW, Elmaleh DR, Barrow SA, Meltzer P, Hanson RN, Madras BK
SPECT imaging of dopamine transporter sites in normal and MPTP-Treated rhesus monkeys. J Nucl Med. 1997 Jan; 38(1):144-50.
SPECT imaging of dopamine transporter sites in normal and MPTP-Treated rhesus monkeys.
Goulet M, Miller GM, Bendor J, Liu S, Meltzer PC, Madras BK
Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates? Synapse. 2001 Dec 01; 42(3):129-40.
Non-amines, drugs without an amine nitrogen, potently block serotonin transport: novel antidepressant candidates?
Severe depletion of cocaine recognition sites associated with the dopamine transporter in Parkinson's-diseased striatum. Synapse. 1991 Sep; 9(1):43-9.
Severe depletion of cocaine recognition sites associated with the dopamine transporter in Parkinson's-diseased striatum.
Imaging of dopamine transporters in humans with technetium-99m TRODAT-1. Eur J Nucl Med. 1997 Apr; 24(4):462-3.
Imaging of dopamine transporters in humans with technetium-99m TRODAT-1.
Madras BK, Gracz LM, Fahey MA, Elmaleh D, Meltzer PC, Liang AY, Stopa EG, Babich J, Fischman AJ
Altropane, a SPECT or PET imaging probe for dopamine neurons: III. Human dopamine transporter in postmortem normal and Parkinson's diseased brain. Synapse. 1998 Jun; 29(2):116-27.
Altropane, a SPECT or PET imaging probe for dopamine neurons: III. Human dopamine transporter in postmortem normal and Parkinson's diseased brain.
Rosenzweig-Lipson S, Bergman J, Spealman RD, Madras BK
Stereoselective behavioral effects of Lu 19-005 in monkeys: relation to binding at cocaine recognition sites. Psychopharmacology (Berl). 1992; 107(2-3):186-94.
Stereoselective behavioral effects of Lu 19-005 in monkeys: relation to binding at cocaine recognition sites.
Meltzer PC, Blundell P, Huang H, Liu S, Yong YF, Madras BK
3-Aryl-2-carbomethoxybicyclo[3.2.1]oct-2-enes inhibit WIN 35,428 binding potently and selectively at the dopamine transporter. Bioorg Med Chem. 2000 Mar; 8(3):581-90.
3-Aryl-2-carbomethoxybicyclo[3.2.1]oct-2-enes inhibit WIN 35,428 binding potently and selectively at the dopamine transporter.