Research Christoph's research interests are at the intersection of biostatistical methodology, numerical analysis, and computer science. Formally trained in all 3 areas, Christoph headed the analysis of the first genome-wide association study for complex diseases, the longitudinal analysis of BMI in the Framingham Heart Study. To address the challenges of this first wave of "big data" in genetics, Christoph's group developed statistical methodology to maximize power in such studies that minimize the effects of the multiple testing problem in GWAS and developed massively parallel software implementations for the analysis that also efficiently scale with the study size (PBAT software package). Christoph's group then successfully commercialized the package in collaboration with GoldenHelix. Currently, Christoph's group focuses on the statistical and computational challenges posed by whole-genome sequencing studies, e.g. powerful analysis methodology, clustering approaches of the genome, approaches to permutation testing, storage algorithm, etc. Christoph is also involved in collaborative research in Asthma Genetics, COPD Genetics, and Alzheimer's Genetics. Education Ph.D., 2000, University of Reading, United Kingdom
Zhang D, Shankar P, Xu Z, Harnisch B, Chen G, Lange C, Lee SJ, Valdez H, Lederman MM, Lieberman J
Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic. Blood. 2003 Jan 01; 101(1):226-35.
Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic.
Family-based association tests for survival and times-to-onset analysis. Stat Med. 2004 Jan 30; 23(2):179-89.
Family-based association tests for survival and times-to-onset analysis.
Randolph AG, Lange C, Silverman EK, Lazarus R, Silverman ES, Raby B, Brown A, Ozonoff A, Richter B, Weiss ST
The IL12B gene is associated with asthma. Am J Hum Genet. 2004 Oct; 75(4):709-15.
The IL12B gene is associated with asthma.
van Ingen J, Aksamit T, Andrejak C, Böttger EC, Cambau E, Daley CL, Griffith DE, Guglielmetti L, Holland SM, Huitt GA, Koh WJ, Lange C, Leitman P, Marras TK, Morimoto K, Olivier KN, Santin M, Stout JE, Thomson R, Tortoli E, Wallace RJ, Winthrop KL, Wagner D
Treatment outcome definitions in nontuberculous mycobacterial pulmonary disease: an NTM-NET consensus statement. Eur Respir J. 2018 03; 51(3).
Treatment outcome definitions in nontuberculous mycobacterial pulmonary disease: an NTM-NET consensus statement.
Jiang H, Harrington D, Raby BA, Bertram L, Blacker D, Weiss ST, Lange C
Family-based association test for time-to-onset data with time-dependent differences between the hazard functions. Genet Epidemiol. 2006 Feb; 30(2):124-32.
Family-based association test for time-to-onset data with time-dependent differences between the hazard functions.
Murphy A, McQueen MB, Su J, Kraft P, Lazarus R, Laird NM, Lange C, Van Steen K
Genomic screening in family-based association testing. BMC Genet. 2005 Dec 30; 6 Suppl 1:S115.
Genomic screening in family-based association testing.
Lange C, van Leth F, Mitnick CD, Dheda K, Günther G
Time to revise WHO-recommended definitions of MDR-TB treatment outcomes. Lancet Respir Med. 2018 04; 6(4):246-248.
Time to revise WHO-recommended definitions of MDR-TB treatment outcomes.
Dheda K, Gumbo T, Lange C, Horsburgh CR, Furin J
Pan-tuberculosis regimens: an argument against. Lancet Respir Med. 2018 04; 6(4):240-242.
Pan-tuberculosis regimens: an argument against.
Lasky-Su J, Biederman J, Laird N, Tsuang M, Doyle AE, Smoller JW, Lange C, Faraone SV
Evidence for an association of the dopamine D5 receptor gene on age at onset of attention deficit hyperactivity disorder. Ann Hum Genet. 2007 Sep; 71(Pt 5):648-59.
Evidence for an association of the dopamine D5 receptor gene on age at onset of attention deficit hyperactivity disorder.
Mapping quantitative trait Loci using generalized estimating equations. Genetics. 2001 Nov; 159(3):1325-37.
Mapping quantitative trait Loci using generalized estimating equations.
On prediction of genetic values in marker-assisted selection. Genetics. 2001 Nov; 159(3):1375-81.
On prediction of genetic values in marker-assisted selection.
Lasky-Su J, Won S, Mick E, Anney RJ, Franke B, Neale B, Biederman J, Smalley SL, Loo SK, Todorov A, Faraone SV, Weiss ST, Lange C
On genome-wide association studies for family-based designs: an integrative analysis approach combining ascertained family samples with unselected controls. Am J Hum Genet. 2010 Apr 09; 86(4):573-80.
On genome-wide association studies for family-based designs: an integrative analysis approach combining ascertained family samples with unselected controls.
Wan ES, Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Won S, Lange C, Pillai SG, Anderson WH, Kong X, Lomas DA, Bakke PS, Gulsvik A, Regan EA, Murphy JR, Make BJ, Crapo JD, Wouters EF, Celli BR, Silverman EK, DeMeo DL
American journal of respiratory cell and molecular biology
Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):304-10.
Genome-wide association analysis of body mass in chronic obstructive pulmonary disease.
Schjeide BM, McQueen MB, Mullin K, DiVito J, Hogan MF, Parkinson M, Hooli B, Lange C, Blacker D, Tanzi RE, Bertram L
Assessment of Alzheimer's disease case-control associations using family-based methods. Neurogenetics. 2009 Feb; 10(1):19-25.
Assessment of Alzheimer's disease case-control associations using family-based methods.
Lasky-Su J, Anney RJ, Neale BM, Franke B, Zhou K, Maller JB, Vasquez AA, Chen W, Asherson P, Buitelaar J, Banaschewski T, Ebstein R, Gill M, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen HC, Taylor E, Daly M, Laird N, Lange C, Faraone SV
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 05; 147B(8):1355-8.
Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder.
Fardo DW, Becker KD, Bertram L, Tanzi RE, Lange C
European journal of human genetics : EJHG
Recovering unused information in genome-wide association studies: the benefit of analyzing SNPs out of Hardy-Weinberg equilibrium. Eur J Hum Genet. 2009 Dec; 17(12):1676-82.
Recovering unused information in genome-wide association studies: the benefit of analyzing SNPs out of Hardy-Weinberg equilibrium.
Wu AC, Himes BE, Lasky-Su J, Litonjua A, Li L, Lange C, Lima J, Irvin CG, Weiss ST
Development of a Pharmacogenetic Predictive Test in asthma: proof of concept. Pharmacogenet Genomics. 2010 Feb; 20(2):86-93.
Development of a Pharmacogenetic Predictive Test in asthma: proof of concept.
Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Hersh CP, DeMeo DL, Hunninghake GM, Litonjua AA, Sparrow D, Lange C, Won S, Murphy JR, Beaty TH, Regan EA, Make BJ, Hokanson JE, Crapo JD, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Pillai SG, Silverman EK
Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet. 2010 Mar; 42(3):200-2.
Variants in FAM13A are associated with chronic obstructive pulmonary disease.
Hunninghake GM, Cho MH, Tesfaigzi Y, Soto-Quiros ME, Avila L, Lasky-Su J, Stidley C, Melén E, Söderhäll C, Hallberg J, Kull I, Kere J, Svartengren M, Pershagen G, Wickman M, Lange C, Demeo DL, Hersh CP, Klanderman BJ, Raby BA, Sparrow D, Shapiro SD, Silverman EK, Litonjua AA, Weiss ST, Celedón JC
MMP12, lung function, and COPD in high-risk populations. N Engl J Med. 2009 Dec 31; 361(27):2599-608.
MMP12, lung function, and COPD in high-risk populations.
Lasky-Su J, Murphy A, McQueen MB, Weiss S, Lange C
An omnibus test for family-based association studies with multiple SNPs and multiple phenotypes. Eur J Hum Genet. 2010 Jun; 18(6):720-5.
An omnibus test for family-based association studies with multiple SNPs and multiple phenotypes.
Hersh CP, Raby BA, Soto-Quirós ME, Murphy AJ, Avila L, Lasky-Su J, Sylvia JS, Klanderman BJ, Lange C, Weiss ST, Celedón JC
American journal of respiratory and critical care medicine
Comprehensive testing of positionally cloned asthma genes in two populations. Am J Respir Crit Care Med. 2007 Nov 01; 176(9):849-57.
Comprehensive testing of positionally cloned asthma genes in two populations.
Proceedings of the National Academy of Sciences of the United States of America
Estimating the number of unseen variants in the human genome. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5008-13.
Estimating the number of unseen variants in the human genome.
On quality control measures in genome-wide association studies: a test to assess the genotyping quality of individual probands in family-based association studies and an application to the HapMap data. PLoS Genet. 2009 Jul; 5(7):e1000572.
On quality control measures in genome-wide association studies: a test to assess the genotyping quality of individual probands in family-based association studies and an application to the HapMap data.
Won S, Wilk JB, Mathias RA, O'Donnell CJ, Silverman EK, Barnes K, O'Connor GT, Weiss ST, Lange C
On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies. PLoS Genet. 2009 Nov; 5(11):e1000741.
On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies.
Cho MH, Castaldi PJ, Wan ES, Siedlinski M, Hersh CP, Demeo DL, Himes BE, Sylvia JS, Klanderman BJ, Ziniti JP, Lange C, Litonjua AA, Sparrow D, Regan EA, Make BJ, Hokanson JE, Murray T, Hetmanski JB, Pillai SG, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard S, Wouters E, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Silverman EK
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet. 2012 Feb 15; 21(4):947-57.
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.
Degenhardt F, Priebe L, Herms S, Mattheisen M, Mühleisen TW, Meier S, Moebus S, Strohmaier J, Groß M, Breuer R, Lange C, Hoffmann P, Meyer-Lindenberg A, Heinz A, Walter H, Lucae S, Wolf C, Müller-Myhsok B, Holsboer F, Maier W, Rietschel M, Nöthen MM, Cichon S
Association between copy number variants in 16p11.2 and major depressive disorder in a German case-control sample. Am J Med Genet B Neuropsychiatr Genet. 2012 Apr; 159B(3):263-73.
Association between copy number variants in 16p11.2 and major depressive disorder in a German case-control sample.
Handling the data management needs of high-throughput sequencing data: SpeedGene, a compression algorithm for the efficient storage of genetic data. BMC Bioinformatics. 2012 May 16; 13:100.
Handling the data management needs of high-throughput sequencing data: SpeedGene, a compression algorithm for the efficient storage of genetic data.
Andresen E, Günther G, Bullwinkel J, Lange C, Heine H
Increased expression of beta-defensin 1 (DEFB1) in chronic obstructive pulmonary disease. PLoS One. 2011; 6(7):e21898.
Increased expression of beta-defensin 1 (DEFB1) in chronic obstructive pulmonary disease.
Silverman EK, Kwiatkowski DJ, Sylvia JS, Lazarus R, Drazen JM, Lange C, Laird NM, Weiss ST
The Journal of allergy and clinical immunology
Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program. J Allergy Clin Immunol. 2003 Nov; 112(5):870-6.
Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program.
Lange C, van Steen K, Andrew T, Lyon H, DeMeo DL, Raby B, Murphy A, Silverman EK, MacGregor A, Weiss ST, Laird NM
Statistical applications in genetics and molecular biology
A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. Stat Appl Genet Mol Biol. 2004; 3:Article17.
A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects.
Prokopenko D, Sakornsakolpat P, Fier HL, Qiao D, Parker MM, McDonald MN, Manichaikul A, Rich SS, Barr RG, Williams CJ, Brantly ML, Lange C, Beaty TH, Crapo JD, Silverman EK, Cho MH
Whole-Genome Sequencing in Severe Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2018 11; 59(5):614-622.
Whole-Genome Sequencing in Severe Chronic Obstructive Pulmonary Disease.
Adhikari K, AlChawa T, Ludwig K, Mangold E, Laird N, Lange C
Is it rare or common? Genet Epidemiol. 2012 Jul; 36(5):419-29.
Lyon H, Lange C, Lake S, Silverman EK, Randolph AG, Kwiatkowski D, Raby BA, Lazarus R, Weiland KM, Laird N, Weiss ST
IL10 gene polymorphisms are associated with asthma phenotypes in children. Genet Epidemiol. 2004 Feb; 26(2):155-65.
IL10 gene polymorphisms are associated with asthma phenotypes in children.
Family-based methods for linkage and association analysis. Adv Genet. 2008; 60:219-52.
Family-based methods for linkage and association analysis.
Ionita-Laza I, Rogers AJ, Lange C, Raby BA, Lee C
Genetic association analysis of copy-number variation (CNV) in human disease pathogenesis. Genomics. 2009 Jan; 93(1):22-6.
Genetic association analysis of copy-number variation (CNV) in human disease pathogenesis.
Himes BE, Hunninghake GM, Baurley JW, Rafaels NM, Sleiman P, Strachan DP, Wilk JB, Willis-Owen SA, Klanderman B, Lasky-Su J, Lazarus R, Murphy AJ, Soto-Quiros ME, Avila L, Beaty T, Mathias RA, Ruczinski I, Barnes KC, Celedón JC, Cookson WO, Gauderman WJ, Gilliland FD, Hakonarson H, Lange C, Moffatt MF, O'Connor GT, Raby BA, Silverman EK, Weiss ST
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet. 2009 May; 84(5):581-93.
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.
Kalsdorf B, Scriba TJ, Wood K, Day CL, Dheda K, Dawson R, Hanekom WA, Lange C, Wilkinson RJ
HIV-1 infection impairs the bronchoalveolar T-cell response to mycobacteria. Am J Respir Crit Care Med. 2009 Dec 15; 180(12):1262-70.
HIV-1 infection impairs the bronchoalveolar T-cell response to mycobacteria.
Lange C, Sommerfeld M, Namsolleck P, Kintscher U, Unger T, Kaschina E
AT2R (Angiotensin AT2 Receptor) Agonist, Compound 21, Prevents Abdominal Aortic Aneurysm Progression in the Rat. Hypertension. 2018 09; 72(3):e20-e29.
AT2R (Angiotensin AT2 Receptor) Agonist, Compound 21, Prevents Abdominal Aortic Aneurysm Progression in the Rat.
Hoffmann TJ, Vansteelandt S, Lange C, Silverman EK, DeMeo DL, Laird NM
Combining disease models to test for gene-environment interaction in nuclear families. Biometrics. 2011 Dec; 67(4):1260-70.
Combining disease models to test for gene-environment interaction in nuclear families.
Himes BE, Klanderman B, Ziniti J, Senter-Sylvia J, Soto-Quiros ME, Avila L, Celedón JC, Lange C, Mariani TJ, Lasky-Su J, Hersh CP, Raby BA, Silverman EK, Weiss ST, DeMeo DL
Association of SERPINE2 with asthma. Chest. 2011 Sep; 140(3):667-674.
On the parsing of statistical information in family-based association testing. Nat Genet. 2007 Mar; 39(3):281-2.
On the parsing of statistical information in family-based association testing.
Lasky-Su J, Lange C, Biederman J, Tsuang M, Doyle AE, Smoller JW, Laird N, Faraone S
Family-based association analysis of a statistically derived quantitative traits for ADHD reveal an association in DRD4 with inattentive symptoms in ADHD individuals. Am J Med Genet B Neuropsychiatr Genet. 2008 Jan 05; 147B(1):100-6.
Family-based association analysis of a statistically derived quantitative traits for ADHD reveal an association in DRD4 with inattentive symptoms in ADHD individuals.
Lasky-Su J, Neale BM, Franke B, Anney RJ, Zhou K, Maller JB, Vasquez AA, Chen W, Asherson P, Buitelaar J, Banaschewski T, Ebstein R, Gill M, Miranda A, Mulas F, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen HC, Taylor E, Daly M, Laird N, Lange C, Faraone SV
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 05; 147B(8):1345-54.
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.
Salzer HJF, Kuempers C, Pasternack H, Heyckendorf J, Bialek R, Palade E, Hundack L, Kalsdorf B, Lange C
An Unexpected Endobronchial Mass Appearing During Bronchoscopy. Chest. 2018 07; 154(1):e13-e21.
An Unexpected Endobronchial Mass Appearing During Bronchoscopy.
Qiao D, Ameli A, Prokopenko D, Chen H, Kho AT, Parker MM, Morrow J, Hobbs BD, Liu Y, Beaty TH, Crapo JD, Barnes KC, Nickerson DA, Bamshad M, Hersh CP, Lomas DA, Agusti A, Make BJ, Calverley PMA, Donner CF, Wouters EF, Vestbo J, Paré PD, Levy RD, Rennard SI, Tal-Singer R, Spitz MR, Sharma A, Ruczinski I, Lange C, Silverman EK, Cho MH
Whole exome sequencing analysis in severe chronic obstructive pulmonary disease. Hum Mol Genet. 2018 11 01; 27(21):3801-3812.
Whole exome sequencing analysis in severe chronic obstructive pulmonary disease.
Günther G, van Leth F, Alexandru S, Altet N, Avsar K, Bang D, Barbuta R, Bothamley G, Ciobanu A, Crudu V, Danilovits M, Dedicoat M, Duarte R, Gualano G, Kunst H, de Lange W, Leimane V, McLaughlin AM, Magis-Escurra C, Muylle I, Polcová V, Popa C, Rumetshofer R, Skrahina A, Solodovnikova V, Spinu V, Tiberi S, Viiklepp P, Lange C
Clinical Management of Multidrug-Resistant Tuberculosis in 16 European Countries. Am J Respir Crit Care Med. 2018 08 01; 198(3):379-386.
Clinical Management of Multidrug-Resistant Tuberculosis in 16 European Countries.
Salzer HJF, Stoney RJ, Angelo KM, Rolling T, Grobusch MP, Libman M, López-Vélez R, Duvignaud A, Ásgeirsson H, Crespillo-Andújar C, Schwartz E, Gautret P, Bottieau E, Jordan S, Lange C, Hamer DH
Epidemiological aspects of travel-related systemic endemic mycoses: a GeoSentinel analysis, 1997-2017. J Travel Med. 2018 08 01; 25(1).
Epidemiological aspects of travel-related systemic endemic mycoses: a GeoSentinel analysis, 1997-2017.
Vansteelandt S, Goetgeluk S, Lutz S, Waldman I, Lyon H, Schadt EE, Weiss ST, Lange C
On the adjustment for covariates in genetic association analysis: a novel, simple principle to infer direct causal effects. Genet Epidemiol. 2009 Jul; 33(5):394-405.
On the adjustment for covariates in genetic association analysis: a novel, simple principle to infer direct causal effects.
A Bayesian approach to genetic association studies with family-based designs. Genet Epidemiol. 2010 Sep; 34(6):569-74.
A Bayesian approach to genetic association studies with family-based designs.
Methods in molecular biology (Clifton, N.J.)
Two-stage testing strategies for genome-wide association studies in family-based designs. Methods Mol Biol. 2010; 620:485-96.
Two-stage testing strategies for genome-wide association studies in family-based designs.
Ahmad N, Ahuja SD, Akkerman OW, Alffenaar JC, Anderson LF, Baghaei P, Bang D, Barry PM, Bastos ML, Behera D, Benedetti A, Bisson GP, Boeree MJ, Bonnet M, Brode SK, Brust JCM, Cai Y, Caumes E, Cegielski JP, Centis R, Chan PC, Chan ED, Chang KC, Charles M, Cirule A, Dalcolmo MP, D'Ambrosio L, de Vries G, Dheda K, Esmail A, Flood J, Fox GJ, Fréchet-Jachym M, Fregona G, Gayoso R, Gegia M, Gler MT, Gu S, Guglielmetti L, Holtz TH, Hughes J, Isaakidis P, Jarlsberg L, Kempker RR, Keshavjee S, Khan FA, Kipiani M, Koenig SP, Koh WJ, Kritski A, Kuksa L, Kvasnovsky CL, Kwak N, Lan Z, Lange C, Laniado-Laborín R, Lee M, Leimane V, Leung CC, Leung EC, Li PZ, Lowenthal P, Maciel EL, Marks SM, Mase S, Mbuagbaw L, Migliori GB, Milanov V, Miller AC, Mitnick CD, Modongo C, Mohr E, Monedero I, Nahid P, Ndjeka N, O'Donnell MR, Padayatchi N, Palmero D, Pape JW, Podewils LJ, Reynolds I, Riekstina V, Robert J, Rodriguez M, Seaworth B, Seung KJ, Schnippel K, Shim TS, Singla R, Smith SE, Sotgiu G, Sukhbaatar G, Tabarsi P, Tiberi S, Trajman A, Trieu L, Udwadia ZF, van der Werf TS, Veziris N, Viiklepp P, Vilbrun SC, Walsh K, Westenhouse J, Yew WW, Yim JJ, Zetola NM, Zignol M, Menzies D
Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis. Lancet. 2018 09 08; 392(10150):821-834.
Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis.
Siedlinski M, Tingley D, Lipman PJ, Cho MH, Litonjua AA, Sparrow D, Bakke P, Gulsvik A, Lomas DA, Anderson W, Kong X, Rennard SI, Beaty TH, Hokanson JE, Crapo JD, Lange C, Silverman EK
Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility. Hum Genet. 2013 Apr; 132(4):431-41.
Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility.
Family-based designs in the age of large-scale gene-association studies. Nat Rev Genet. 2006 May; 7(5):385-94.
Family-based designs in the age of large-scale gene-association studies.
P2BAT: a massive parallel implementation of PBAT for genome-wide association studies in R. Bioinformatics. 2006 Dec 15; 22(24):3103-5.
P2BAT: a massive parallel implementation of PBAT for genome-wide association studies in R.
Ding X, Weiss S, Raby B, Lange C, Laird NM
Impact of population stratification on family-based association tests with longitudinal measurements. Stat Appl Genet Mol Biol. 2009; 8:Article 17.
Impact of population stratification on family-based association tests with longitudinal measurements.
Sebro R, Lange C, Laird NM, Rogus JJ, Risch NJ
Differentiating population stratification from genotyping error using family data. Ann Hum Genet. 2012 Jan; 76(1):42-52.
Differentiating population stratification from genotyping error using family data.
Lange C, Chesov D, Furin J, Udwadia Z, Dheda K
Revising the definition of extensively drug-resistant tuberculosis. Lancet Respir Med. 2018 12; 6(12):893-895.
Revising the definition of extensively drug-resistant tuberculosis.
Lazarus R, Raby BA, Lange C, Silverman EK, Kwiatkowski DJ, Vercelli D, Klimecki WJ, Martinez FD, Weiss ST
TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples. Am J Respir Crit Care Med. 2004 Sep 15; 170(6):594-600.
TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples.
Hersh CP, Demeo DL, Lange C, Litonjua AA, Reilly JJ, Kwiatkowski D, Laird N, Sylvia JS, Sparrow D, Speizer FE, Weiss ST, Silverman EK
Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Am J Respir Cell Mol Biol. 2005 Jul; 33(1):71-8.
Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Clofazimine for the treatment of multidrug-resistant tuberculosis. Clin Microbiol Infect. 2019 02; 25(2):128-130.
Clofazimine for the treatment of multidrug-resistant tuberculosis.
Genetic model testing and statistical power in population-based association studies of quantitative traits. Genet Epidemiol. 2007 May; 31(4):358-62.
Genetic model testing and statistical power in population-based association studies of quantitative traits.
Litonjua AA, Lasky-Su J, Schneiter K, Tantisira KG, Lazarus R, Klanderman B, Lima JJ, Irvin CG, Peters SP, Hanrahan JP, Liggett SB, Hawkins GA, Meyers DA, Bleecker ER, Lange C, Weiss ST
ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. Am J Respir Crit Care Med. 2008 Oct 01; 178(7):688-94.
ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts.
Murphy A, Lasky-Su J, Tantisira KG, Litonjua AA, Lange C, Weiss ST
Genome-wide association studies of family data in pharmacogenetics: a case study. Curr Pharm Des. 2009; 15(32):3764-72.
Genome-wide association studies of family data in pharmacogenetics: a case study.
Andresen E, Lange C, Strodthoff D, Goldmann T, Fischer N, Sahly H, Branscheid D, Heine H
S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection. BMC Pulm Med. 2011 Feb 15; 11:10.
S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection.
Won S, Lu Q, Bertram L, Tanzi RE, Lange C
On the meta-analysis of genome-wide association studies: a robust and efficient approach to combine population and family-based studies. Hum Hered. 2012; 73(1):35-46.
On the meta-analysis of genome-wide association studies: a robust and efficient approach to combine population and family-based studies.
A comparison of popular TDT-generalizations for family-based association analysis. Genet Epidemiol. 2019 04; 43(3):300-317.
A comparison of popular TDT-generalizations for family-based association analysis.
van Leth F, Brinkmann F, Cirillo DM, Dheda K, Duarte R, Guglielmetti L, Kuksa L, Lange C, Mitnick C, Skrahina A, Zaman K, Bothamley G
The Tuberculosis Network European Trials group (TBnet) ERS Clinical Research Collaboration: addressing drug-resistant tuberculosis through European cooperation. Eur Respir J. 2019 01; 53(1).
The Tuberculosis Network European Trials group (TBnet) ERS Clinical Research Collaboration: addressing drug-resistant tuberculosis through European cooperation.
Chen G, Shankar P, Lange C, Valdez H, Skolnik PR, Wu L, Manjunath N, Lieberman J
CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection. Blood. 2001 Jul 01; 98(1):156-64.
CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection.
Ionita-Laza I, Perry GH, Raby BA, Klanderman B, Lee C, Laird NM, Weiss ST, Lange C
On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test. Genet Epidemiol. 2008 Apr; 32(3):273-84.
On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test.
Degnan JH, Lasky-Su J, Raby BA, Xu M, Molony C, Schadt EE, Lange C
Genomics and genome-wide association studies: an integrative approach to expression QTL mapping. Genomics. 2008 Sep; 92(3):129-33.
Genomics and genome-wide association studies: an integrative approach to expression QTL mapping.
Bertram L, Lange C, Mullin K, Parkinson M, Hsiao M, Hogan MF, Schjeide BM, Hooli B, Divito J, Ionita I, Jiang H, Laird N, Moscarillo T, Ohlsen KL, Elliott K, Wang X, Hu-Lince D, Ryder M, Murphy A, Wagner SL, Blacker D, Becker KD, Tanzi RE
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet. 2008 Nov; 83(5):623-32.
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.
Levy H, Murphy A, Zou F, Gerard C, Klanderman B, Schuemann B, Lazarus R, García KC, Celedón JC, Drumm M, Dahmer M, Quasney M, Schneck K, Reske M, Knowles MR, Pier GB, Lange C, Weiss ST
IL1B polymorphisms modulate cystic fibrosis lung disease. Pediatr Pulmonol. 2009 Jun; 44(6):580-93.
IL1B polymorphisms modulate cystic fibrosis lung disease.
DeMeo DL, Mariani T, Bhattacharya S, Srisuma S, Lange C, Litonjua A, Bueno R, Pillai SG, Lomas DA, Sparrow D, Shapiro SD, Criner GJ, Kim HP, Chen Z, Choi AM, Reilly J, Silverman EK
Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. Am J Hum Genet. 2009 Oct; 85(4):493-502.
Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene.
Lipman PJ, Cho MH, Bakke P, Gulsvik A, Kong X, Lomas DA, Anderson W, Silverman EK, Lange C
On the follow-up of genome-wide association studies: an overall test for the most promising SNPs. Genet Epidemiol. 2011 Jul; 35(5):303-9.
On the follow-up of genome-wide association studies: an overall test for the most promising SNPs.
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Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med. 2011 Sep 29; 365(13):1173-83.
Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.
Nasser E, Mangold E, Tradowsky DC, Fier H, Becker J, Boehmer AC, Herberz R, Fricker N, Barth S, Wahle P, Nowak S, Reutter H, Reich RH, Lauster C, Braumann B, Kreusch T, Hemprich A, Pötzsch B, Hoffmann P, Kramer FJ, Knapp M, Lange C, Nöthen MM, Ludwig KU
Birth defects research. Part A, Clinical and molecular teratology
Resequencing of VAX1 in patients with nonsyndromic cleft lip with or without cleft palate. Birth Defects Res A Clin Mol Teratol. 2012 Nov; 94(11):925-33.
Resequencing of VAX1 in patients with nonsyndromic cleft lip with or without cleft palate.
Ragland MF, Benway CJ, Lutz SM, Bowler RP, Hecker J, Hokanson JE, Crapo JD, Castaldi PJ, DeMeo DL, Hersh CP, Hobbs BD, Lange C, Beaty TH, Cho MH, Silverman EK
Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. Am J Respir Crit Care Med. 2019 09 15; 200(6):677-690.
Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene.
Harvard T.H. Chan School of Public Health
Lecturer on Global Health and Social Medicine, Part-time
Mary B. Saltonstall Professor of Ethics and Population Health, Emeritus
Gilbert S. Omenn, MD ’65, PhD Associate Professor of Biomedical Informatics
Harvey V. Fineberg Professor of Public Health, Emerita
Professor of Global Heath and Social Medicine
Ronda Stryker and William Johnston Professor of Global Health
Wang L, Lee S, Qiao D, Cho MH, Silverman EK, Lange C, Won S
metaFARVAT: An Efficient Tool for Meta-Analysis of Family-Based, Case-Control, and Population-Based Rare Variant Association Studies. Front Genet. 2019; 10:572.
metaFARVAT: An Efficient Tool for Meta-Analysis of Family-Based, Case-Control, and Population-Based Rare Variant Association Studies.
Tortoli E, Brown-Elliott BA, Chalmers JD, Cirillo DM, Daley CL, Emler S, Floto RA, Garcia MJ, Hoefsloot W, Koh WJ, Lange C, Loebinger M, Maurer FP, Morimoto K, Niemann S, Richter E, Turenne CY, Vasireddy R, Vasireddy S, Wagner D, Wallace RJ, Wengenack N, van Ingen J
Same meat, different gravy: ignore the new names of mycobacteria. Eur Respir J. 2019 Jul; 54(1).
Same meat, different gravy: ignore the new names of mycobacteria.
Effect of population stratification on SNP-by-environment interaction. Genet Epidemiol. 2019 12; 43(8):1046-1055.
Effect of population stratification on SNP-by-environment interaction.
Kachroo P, Hecker J, Chawes BL, Ahluwalia TS, Cho MH, Qiao D, Kelly RS, Chu SH, Virkud YV, Huang M, Barnes KC, Burchard EG, Eng C, Hu D, Celedón JC, Daya M, Levin AM, Gui H, Williams LK, Forno E, Mak ACY, Avila L, Soto-Quiros ME, Cloutier MM, Acosta-Pérez E, Canino G, Bønnelykke K, Bisgaard H, Raby BA, Lange C, Weiss ST, Lasky-Su JA
Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma. Chest. 2019 12; 156(6):1068-1079.
Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma.
Hecker J, Ruczinski I, Cho MH, Silverman EK, Coull B, Lange C
A flexible and nearly optimal sequential testing approach to randomized testing: QUICK-STOP. Genet Epidemiol. 2020 03; 44(2):139-147.
A flexible and nearly optimal sequential testing approach to randomized testing: QUICK-STOP.
Miotto P, Tessema B, Tagliani E, Chindelevitch L, Starks AM, Emerson C, Hanna D, Kim PS, Liwski R, Zignol M, Gilpin C, Niemann S, Denkinger CM, Fleming J, Warren RM, Crook D, Posey J, Gagneux S, Hoffner S, Rodrigues C, Comas I, Engelthaler DM, Murray M, Alland D, Rigouts L, Lange C, Dheda K, Hasan R, Ranganathan UDK, McNerney R, Ezewudo M, Cirillo DM, Schito M, Köser CU, Rodwell TC
A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis. Eur Respir J. 2017 12; 50(6).
A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis.
Prokopenko D, Hecker J, Kirchner R, Chapman BA, Hoffman O, Mullin K, Hide W, Bertram L, Laird N, DeMeo DL, Lange C, Tanzi RE
Identification of Novel Alzheimer's Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data. Sci Rep. 2020 03 19; 10(1):5029.
Identification of Novel Alzheimer's Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data.
Lutz SM, Sordillo JE, Hokanson JE, Chen Wu A, Lange C
The effects of misspecification of the mediator and outcome in mediation analysis. Genet Epidemiol. 2020 06; 44(4):400-403.
The effects of misspecification of the mediator and outcome in mediation analysis.
bioRxiv : the preprint server for biology
Unsupervised cluster analysis of SARS-CoV-2 genomes reflects its geographic progression and identifies distinct genetic subgroups of SARS-CoV-2 virus. bioRxiv. 2020 Nov 20.
Unsupervised cluster analysis of SARS-CoV-2 genomes reflects its geographic progression and identifies distinct genetic subgroups of SARS-CoV-2 virus.
Hahn G, Cho MH, Weiss ST, Silverman EK, Lange C
Unsupervised cluster analysis of SARS-CoV-2 genomes indicates that recent (June 2020) cases in Beijing are from a genetic subgroup that consists of mostly European and South(east) Asian samples, of which the latter are the most recent. bioRxiv. 2020 Jun 30.
Unsupervised cluster analysis of SARS-CoV-2 genomes indicates that recent (June 2020) cases in Beijing are from a genetic subgroup that consists of mostly European and South(east) Asian samples, of which the latter are the most recent.
Lee S, Lasky-Su JA, Lange C, Kim W, Kumar PL, McDonald MN, Vaz Fragoso CA, Laurie C, Raby BA, Celedón JC, Cho MH, Won S, Weiss ST, Hecker J
A novel locus for exertional dyspnoea in childhood asthma. Eur Respir J. 2021 02; 57(2).
A novel locus for exertional dyspnoea in childhood asthma.
Hahn G, Lutz SM, Hecker J, Prokopenko D, Cho MH, Silverman EK, Weiss ST, Lange C
locStra: Fast analysis of regional/global stratification in whole-genome sequencing studies. Genet Epidemiol. 2021 02; 45(1):82-98.
locStra: Fast analysis of regional/global stratification in whole-genome sequencing studies.
Lee S, Lasky-Su J, Kim W, Won S, Laurie C, Celedón JC, Lange C, Weiss ST, Hecker J
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
An interaction of the 17q12-21 locus with mold exposure in childhood asthma. Pediatr Allergy Immunol. 2021 02; 32(2):373-376.
An interaction of the 17q12-21 locus with mold exposure in childhood asthma.
Prokopenko D, Morgan SL, Mullin K, Hofmann O, Chapman B, Kirchner R, Amberkar S, Wohlers I, Lange C, Hide W, Bertram L, Tanzi RE
medRxiv : the preprint server for health sciences
Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development. medRxiv. 2020 Nov 04.
Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development.
Hecker J, Townes FW, Kachroo P, Laurie C, Lasky-Su J, Ziniti J, Cho MH, Weiss ST, Laird NM, Lange C
A unifying framework for rare variant association testing in family-based designs, including higher criticism approaches, SKATs, and burden tests. Bioinformatics. 2021 Apr 01; 36(22-23):5432-5438.
A unifying framework for rare variant association testing in family-based designs, including higher criticism approaches, SKATs, and burden tests.
Unsupervised cluster analysis of SARS-CoV-2 genomes reflects its geographic progression and identifies distinct genetic subgroups of SARS-CoV-2 virus. Genet Epidemiol. 2021 04; 45(3):316-323.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development. Alzheimers Dement. 2021 09; 17(9):1509-1527.
Lee S, Lasky-Su J, Won S, Laurie C, Celedón JC, Lange C, Weiss S, Hecker J
Novel recessive locus for body mass index in childhood asthma. Thorax. 2021 12; 76(12):1227-1230.
Novel recessive locus for body mass index in childhood asthma.
Lutz SM, Wu AC, Hokanson JE, Vansteelandt S, Lange C
Caution against examining the role of reverse causality in Mendelian Randomization. Genet Epidemiol. 2021 07; 45(5):445-454.
Caution against examining the role of reverse causality in Mendelian Randomization.
Hahn G, Wu CM, Lee S, Lutz SM, Khurana S, Baden LR, Haneuse S, Qiao D, Hecker J, DeMeo DL, Tanzi RE, Choudhary MC, Etemad B, Mohammadi A, Esmaeilzadeh E, Cho MH, Li JZ, Randolph AG, Laird NM, Weiss ST, Silverman EK, Ribbeck K, Lange C
Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain. Genet Epidemiol. 2021 10; 45(7):685-693.
Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain.
Hahn G, Prokopenko D, Lutz SM, Mullin K, Tanzi RE, Cho MH, Silverman EK, Lange C
A Smoothed Version of the Lassosum Penalty for Fitting Integrated Risk Models Using Summary Statistics or Individual-Level Data. Genes (Basel). 2022 01 06; 13(1).
A Smoothed Version of the Lassosum Penalty for Fitting Integrated Risk Models Using Summary Statistics or Individual-Level Data.
Prokopenko D, Morgan SL, Lange C, Hide W, Bertram L, Tanzi RE
Reply to Neupane et al.: Replication study of AD-associated rare variants. Alzheimers Dement. 2022 04; 18(4):863-864.
Reply to Neupane et al.: Replication study of AD-associated rare variants.
Lutz SM, Voorhies K, Wu AC, Hokanson J, Vansteelandt S, Lange C
The influence of unmeasured confounding on the MR Steiger approach. Genet Epidemiol. 2022 03; 46(2):139-141.
The influence of unmeasured confounding on the MR Steiger approach.
Prokopenko D, Lee S, Hecker J, Mullin K, Morgan S, Katsumata Y, Weiner MW, Fardo DW, Laird N, Bertram L, Hide W, Lange C, Tanzi RE
Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2. Mol Psychiatry. 2022 04; 27(4):1963-1969.
Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2.
Selection bias when inferring the effect direction in Mendelian randomization. Genet Epidemiol. 2022 07; 46(5-6):341-343.
Selection bias when inferring the effect direction in Mendelian randomization.
Voorhies K, Bie R, Hokanson JE, Weiss ST, Chen Wu A, Hecker J, Hahn G, Demeo DL, Silverman E, Cho MH, Lange C, Lutz SM
Covariate adjustment of spirometric and smoking phenotypes: The potential of neural network models. PLoS One. 2022; 17(5):e0266752.
Covariate adjustment of spirometric and smoking phenotypes: The potential of neural network models.
Tang J, Novak T, Hecker J, Grubbs G, Zahra FT, Bellusci L, Pourhashemi S, Chou J, Moffitt K, Halasa NB, Schwartz SP, Walker TC, Tarquinio KM, Zinter MS, Staat MA, Gertz SJ, Cvijanovich NZ, Schuster JE, Loftis LL, Coates BM, Mack EH, Irby K, Fitzgerald JC, Rowan CM, Kong M, Flori HR, Maddux AB, Shein SL, Crandall H, Hume JR, Hobbs CV, Tremoulet AH, Shimizu C, Burns JC, Chen SR, Moon HK, Lange C, Randolph AG, Khurana S
Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C. Nat Commun. 2022 05 27; 13(1):2979.
Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C.
Ge T, Irvin MR, Patki A, Srinivasasainagendra V, Lin YF, Tiwari HK, Armstrong ND, Benoit B, Chen CY, Choi KW, Cimino JJ, Davis BH, Dikilitas O, Etheridge B, Feng YA, Gainer V, Huang H, Jarvik GP, Kachulis C, Kenny EE, Khan A, Kiryluk K, Kottyan L, Kullo IJ, Lange C, Lennon N, Leong A, Malolepsza E, Miles AD, Murphy S, Namjou B, Narayan R, O'Connor MJ, Pacheco JA, Perez E, Rasmussen-Torvik LJ, Rosenthal EA, Schaid D, Stamou M, Udler MS, Wei WQ, Weiss ST, Ng MCY, Smoller JW, Lebo MS, Meigs JB, Limdi NA, Karlson EW
Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations. Genome Med. 2022 06 29; 14(1):70.
Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations.
Kim W, Hecker J, Barr RG, Boerwinkle E, Cade B, Correa A, Dupuis J, Gharib SA, Lange L, London SJ, Morrison AC, O'Connor GT, Oelsner EC, Psaty BM, Vasan RS, Redline S, Rich SS, Rotter JI, Yu B, Lange C, Manichaikul A, Zhou JJ, Sofer T, Silverman EK, Qiao D, Cho MH
Assessing the contribution of rare genetic variants to phenotypes of chronic obstructive pulmonary disease using whole-genome sequence data. Hum Mol Genet. 2022 11 10; 31(22):3873-3885.
Assessing the contribution of rare genetic variants to phenotypes of chronic obstructive pulmonary disease using whole-genome sequence data.
Author Correction: Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C. Nat Commun. 2022 Aug 12; 13(1):4732.
Author Correction: Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C.
Lee S, Zhang Y, Newhams M, Novak T, Thomas PG, Mourani PM, Hall MW, Loftis LL, Cvijanovich NZ, Tarquinio KM, Schwarz AJ, Weiss SL, Thomas NJ, Markovitz B, Cullimore ML, Sanders RC, Zinter MS, Sullivan JE, Halasa NB, Bembea MM, Giuliano JS, Typpo KV, Nofziger RA, Shein SL, Kong M, Coates BM, Weiss ST, Lange C, Su HC, Randolph AG
DDX58 Is Associated With Susceptibility to Severe Influenza Virus Infection in Children and Adolescents. J Infect Dis. 2022 11 28; 226(11):2030-2036.
DDX58 Is Associated With Susceptibility to Severe Influenza Virus Infection in Children and Adolescents.
Hecker J, Chun S, Samiei A, Liu C, Laurie C, Kachroo P, Lutz SM, Lee S, Smith AV, Lasky-Su J, Cho MH, Sharma S, Soto Quirós ME, Avila L, Celedón JC, Raby B, Zhou X, Silverman EK, DeMeo DL, Lange C, Weiss ST
FGF20 and PGM2 variants are associated with childhood asthma in family-based whole-genome sequencing studies. Hum Mol Genet. 2023 01 27; 32(4):696-707.
FGF20 and PGM2 variants are associated with childhood asthma in family-based whole-genome sequencing studies.
Lee S, Prokopenko D, Kelly RS, Lutz S, Ann Lasky-Su J, Cho MH, Laurie C, Celedón JC, Lange C, Weiss ST, Hecker J, DeMeo DL
Zinc finger protein 33B demonstrates sex interaction with atopy-related markers in childhood asthma. Eur Respir J. 2023 01; 61(1).
Zinc finger protein 33B demonstrates sex interaction with atopy-related markers in childhood asthma.
Hecker J, Prokopenko D, Moll M, Lee S, Kim W, Qiao D, Voorhies K, Kim W, Vansteelandt S, Hobbs BD, Cho MH, Silverman EK, Lutz SM, DeMeo DL, Weiss ST, Lange C
A robust and adaptive framework for interaction testing in quantitative traits between multiple genetic loci and exposure variables. PLoS Genet. 2022 11; 18(11):e1010464.
A robust and adaptive framework for interaction testing in quantitative traits between multiple genetic loci and exposure variables.
Ness TE, Meiwes L, Kay A, Mejia R, Lange C, Farhat M, Mandalakas A, DiNardo A
Optimizing DNA Extraction from Pediatric Stool for Diagnosis of Tuberculosis and Use in Next-Generation Sequencing Applications. Microbiol Spectr. 2023 02 14; 11(1):e0226922.
Optimizing DNA Extraction from Pediatric Stool for Diagnosis of Tuberculosis and Use in Next-Generation Sequencing Applications.
Hahn G, Lee S, Prokopenko D, Abraham J, Novak T, Hecker J, Cho M, Khurana S, Baden LR, Randolph AG, Weiss ST, Lange C
Unsupervised outlier detection applied to SARS-CoV-2 nucleotide sequences can identify sequences of common variants and other variants of interest. BMC Bioinformatics. 2022 Dec 19; 23(1):547.
Unsupervised outlier detection applied to SARS-CoV-2 nucleotide sequences can identify sequences of common variants and other variants of interest.
Lee S, Hahn G, Hecker J, Lutz SM, Mullin K, Hide W, Bertram L, DeMeo DL, Tanzi RE, Lange C, Prokopenko D
A comparison between similarity matrices for principal component analysis to assess population stratification in sequenced genetic data sets. Brief Bioinform. 2023 01 19; 24(1).
A comparison between similarity matrices for principal component analysis to assess population stratification in sequenced genetic data sets.
Hayden LP, Hobbs BD, Busch R, Cho MH, Liu M, Lopes-Ramos CM, Lomas DA, Bakke P, Gulsvik A, Silverman EK, Crapo JD, Beaty TH, Laird NM, Lange C, DeMeo DL
X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study. Respir Res. 2023 Feb 01; 24(1):38.
X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study.
Hoth KF, Voorhies K, Wu AC, Lange C, Potash JB, Lutz SM
The Role of Sex in Genetic Association Studies of Depression. J Psychiatr Brain Sci. 2022; 7(6).
The Role of Sex in Genetic Association Studies of Depression.
Hahn G, Novak T, Crawford JC, Randolph AG, Lange C
Longitudinal Analysis of Contrasts in Gene Expression Data. Genes (Basel). 2023 05 24; 14(6).
Longitudinal Analysis of Contrasts in Gene Expression Data.
Hecker J, Lee S, Kachroo P, Prokopenko D, Maaser-Hecker A, Lutz SM, Hahn G, Irizarry R, Weiss ST, DeMeo DL, Lange C
A consistent pattern of slide effects in Illumina DNA methylation BeadChip array data. Epigenetics. 2023 12; 18(1):2257437.
A consistent pattern of slide effects in Illumina DNA methylation BeadChip array data.
Fast computation of the eigensystem of genomic similarity matrices. BMC Bioinformatics. 2024 Jan 25; 25(1):43.
Fast computation of the eigensystem of genomic similarity matrices.
Dheda K, Mirzayev F, Cirillo DM, Udwadia Z, Dooley KE, Chang KC, Omar SV, Reuter A, Perumal T, Horsburgh CR, Murray M, Lange C
Multidrug-resistant tuberculosis. Nat Rev Dis Primers. 2024 Mar 24; 10(1):22.
Lee S, Hecker J, Hahn G, Mullin K, Lutz SM, Tanzi RE, Lange C, Prokopenko D
On the effect heterogeneity of established disease susceptibility loci for Alzheimer's disease across different genetic ancestries. Alzheimers Dement. 2024 05; 20(5):3397-3405.
On the effect heterogeneity of established disease susceptibility loci for Alzheimer's disease across different genetic ancestries.
Voorhies K, Hecker J, Lee S, Hahn G, Prokopenko D, McDonald ML, Wu AC, Wu A, Hokanson JE, Cho MH, Lange C, Hoth KF, Lutz SM
Examining the Effect of Genes on Depression as Mediated by Smoking and Modified by Sex. Genes (Basel). 2024 04 27; 15(5).
Examining the Effect of Genes on Depression as Mediated by Smoking and Modified by Sex.
Hahn G, Prokopenko D, Hecker J, Lutz SM, Mullin K, Sejour L, Hide W, Vlachos I, DeSantis S, Tanzi RE, Lange C
Prediction of disease-free survival for precision medicine using cooperative learning on multi-omic data. Brief Bioinform. 2024 May 23; 25(4).
Prediction of disease-free survival for precision medicine using cooperative learning on multi-omic data.
Hahn G, Prokopenko D, Hecker J, Lutz SM, Mullin K, Tanzi RE, DeSantis S, Lange C
Polygenic hazard score models for the prediction of Alzheimer's free survival using the lasso for Cox's proportional hazards model. Genet Epidemiol. 2025 Jan; 49(1):e22581.
Polygenic hazard score models for the prediction of Alzheimer's free survival using the lasso for Cox's proportional hazards model.
Voorhies K, Young K, Hsu FC, Palmer ND, McDonald MN, Lee S, Hahn G, Hecker J, Prokopenko D, Wu AC, Regan EA, DeMeo D, Kinney GL, Crapo JD, Cho MH, Silverman EK, Lange C, Budoff MJ, Hokanson JE, Lutz SM
Journal of cardiovascular development and disease
Association of PHACTR1 with Coronary Artery Calcium Differs by Sex and Cigarette Smoking. J Cardiovasc Dev Dis. 2024 Jun 27; 11(7).
Association of PHACTR1 with Coronary Artery Calcium Differs by Sex and Cigarette Smoking.
Lienhardt C, Dooley KE, Nahid P, Wells C, Ryckman TS, Kendall EA, Davies G, Brigden G, Churchyard G, Cirillo DM, Di Meco E, Gopinath R, Mitnick C, Scott C, Amanullah F, Bansbach C, Boeree M, Campbell M, Conradie F, Crook A, Daley CL, Dheda K, Diacon A, Gebhard A, Hanna D, Heinrich N, Hesseling A, Holtzman D, Jachym M, Kim P, Lange C, McKenna L, Meintjes G, Ndjeka N, Nhung NV, Nyang'wa BT, Paton NI, Rao R, Rich M, Savic R, Schoeman I, Makokotlela BS, Spigelman M, Sun E, Svensson E, Tisile P, Varaine F, Vernon A, Diul MY, Kasaeva T, Zignol M, Gegia M, Mirzayev F, Schumacher SG
Bulletin of the World Health Organization
Target regimen profiles for tuberculosis treatment. Bull World Health Organ. 2024 Aug 01; 102(8):600-607.
Target regimen profiles for tuberculosis treatment.
Hooli BV, Kovacs-Vajna ZM, Mullin K, Blumenthal MA, Mattheisen M, Zhang C, Lange C, Mohapatra G, Bertram L, Tanzi RE
Rare autosomal copy number variations in early-onset familial Alzheimer's disease. Mol Psychiatry. 2014 Jun; 19(6):676-81.
Rare autosomal copy number variations in early-onset familial Alzheimer's disease.
Modernizing the family-based association testing (FBAT) approach and its software implementation in the FBAT-program
On association analysis of rare variants under population substructure: an approach for the detection of subjects that can cause bias in the analysis--T opt: an outlier detection method. Genet Epidemiol. 2013 Jul; 37(5):431-9.
On association analysis of rare variants under population substructure: an approach for the detection of subjects that can cause bias in the analysis--T opt: an outlier detection method.
Lutz S, Yip WK, Hokanson J, Laird N, Lange C
A general semi-parametric approach to the analysis of genetic association studies in population-based designs. BMC Genet. 2013 Feb 28; 14:13.
A general semi-parametric approach to the analysis of genetic association studies in population-based designs.
Hecker J, Weiss ST, Lasky-Su JA, DeMeo DL, Lange C
Letter to the editor: critical evaluation of the reliability of DNA methylation probes on the illumina MethylationEPIC v1.0 BeadChip microarrays. Epigenetics. 2024 Dec; 19(1):2411470.
Letter to the editor: critical evaluation of the reliability of DNA methylation probes on the illumina MethylationEPIC v1.0 BeadChip microarrays.
Ngai T, Willett J, Waqas M, Fishbein LH, Choi Y, Hahn G, Mullin K, Lange C, Hecker J, Tanzi RE, Prokopenko D
Assessing polyomic risk to predict Alzheimer's disease using a machine learning model. Alzheimers Dement. 2024 12; 20(12):8700-8714.
Assessing polyomic risk to predict Alzheimer's disease using a machine learning model.
Castanho I, Yeganeh PN, Boix CA, Morgan SL, Mathys H, Prokopenko D, White B, Soto LM, Pegoraro G, Shah S, Ploumakis A, Kalavros N, Bennett DA, Lange C, Kim DY, Bertram L, Tsai LH, Kellis M, Tanzi RE, Hide W
Molecular hallmarks of excitatory and inhibitory neuronal resilience and resistance to Alzheimer's disease. bioRxiv. 2025 Jan 15.
Molecular hallmarks of excitatory and inhibitory neuronal resilience and resistance to Alzheimer's disease.
Maslova E, Strøm M, Oken E, Campos H, Lange C, Gold D, Olsen SF
Fish intake during pregnancy and the risk of child asthma and allergic rhinitis - longitudinal evidence from the Danish National Birth Cohort. Br J Nutr. 2013 Oct; 110(7):1313-25.
Fish intake during pregnancy and the risk of child asthma and allergic rhinitis - longitudinal evidence from the Danish National Birth Cohort.
Chang SC, Pauls DL, Lange C, Sasanfar R, Santangelo SL
Sex-specific association of a common variant of the XG gene with autism spectrum disorders. Am J Med Genet B Neuropsychiatr Genet. 2013 Oct; 162B(7):742-50.
Sex-specific association of a common variant of the XG gene with autism spectrum disorders.
Fung WL, Naylor MG, Bennett DA, Lange C, Blacker D
Principal components methods for narrow-sense heritability in the analysis of multidimensional longitudinal cognitive phenotypes. Am J Med Genet B Neuropsychiatr Genet. 2013 Oct; 162B(7):770-8.
Principal components methods for narrow-sense heritability in the analysis of multidimensional longitudinal cognitive phenotypes.
Liang F, Bond E, Sandgren KJ, Smed-Sörensen A, Rangaka MX, Lange C, Koup RA, McComsey GA, Lederman MM, Wilkinson RJ, Andersson J, Loré K
Dendritic cell recruitment in response to skin antigen tests in HIV-1-infected individuals correlates with the level of T-cell infiltration. AIDS. 2013 Apr 24; 27(7):1071-80.
Dendritic cell recruitment in response to skin antigen tests in HIV-1-infected individuals correlates with the level of T-cell infiltration.
Lee S, Kelly RS, Mendez KM, Prokopenko D, Hahn G, Lutz SM, Celedón JC, Clish CB, Weiss ST, Lange C, Lasky-Su JA, Hecker J
On the analysis of metabolite quantitative trait loci: Impact of different data transformations and study designs. Sci Adv. 2025 Apr 11; 11(15):eadp4532.
On the analysis of metabolite quantitative trait loci: Impact of different data transformations and study designs.
Lee S, Kelly RS, Chen Y, Waqas M, Mendez KM, Hecker J, Hahn G, Lutz SM, Celedón JC, Clish CB, Litonjua AA, Chen Q, McGeachie M, Choi Y, Weiss ST, Tanzi RE, Lange C, Prokopenko D, Lasky-Su JA
Metabolomics : Official journal of the Metabolomic Society
Associations of APOE variants with sphingomyelin and cholesterol metabolites across the life-course in diverse populations. Metabolomics. 2025 May 07; 21(3):64.
Associations of APOE variants with sphingomyelin and cholesterol metabolites across the life-course in diverse populations.
Testing for direct genetic effects using a screening step in family-based association studies. Front Genet. 2013; 4:243.
Testing for direct genetic effects using a screening step in family-based association studies.
Won S, Kwon MS, Mattheisen M, Park S, Park C, Kihara D, Cichon S, Ophoff R, Nöthen MM, Rietschel M, Baur M, Uitterlinden AG, Hofmann A, Lange C
Efficient strategy for detecting gene × gene joint action and its application in schizophrenia. Genet Epidemiol. 2014 Jan; 38(1):60-71.
Efficient strategy for detecting gene × gene joint action and its application in schizophrenia.
Duan QL, Lasky-Su J, Himes BE, Qiu W, Litonjua AA, Damask A, Lazarus R, Klanderman B, Irvin CG, Peters SP, Hanrahan JP, Lima JJ, Martinez FD, Mauger D, Chinchilli VM, Soto-Quiros M, Avila L, Celedón JC, Lange C, Weiss ST, Tantisira KG
A genome-wide association study of bronchodilator response in asthmatics. Pharmacogenomics J. 2014 Feb; 14(1):41-7.
A genome-wide association study of bronchodilator response in asthmatics.
Qiao D, Cho MH, Fier H, Bakke PS, Gulsvik A, Silverman EK, Lange C
On the simultaneous association analysis of large genomic regions: a massive multi-locus association test. Bioinformatics. 2014 Jan 15; 30(2):157-64.
On the simultaneous association analysis of large genomic regions: a massive multi-locus association test.
Swanson DM, Blacker D, Alchawa T, Ludwig KU, Mangold E, Lange C
Properties of permutation-based gene tests and controlling type 1 error using a summary statistic based gene test. BMC Genet. 2013 Nov 07; 14:108.
Properties of permutation-based gene tests and controlling type 1 error using a summary statistic based gene test.
Cho MH, McDonald ML, Zhou X, Mattheisen M, Castaldi PJ, Hersh CP, Demeo DL, Sylvia JS, Ziniti J, Laird NM, Lange C, Litonjua AA, Sparrow D, Casaburi R, Barr RG, Regan EA, Make BJ, Hokanson JE, Lutz S, Dudenkov TM, Farzadegan H, Hetmanski JB, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Crapo JD, Silverman EK, Beaty TH
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med. 2014 Mar; 2(3):214-25.
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis.
McDonald ML, Diaz AA, Ross JC, San Jose Estepar R, Zhou L, Regan EA, Eckbo E, Muralidhar N, Come CE, Cho MH, Hersh CP, Lange C, Wouters E, Casaburi RH, Coxson HO, Macnee W, Rennard SI, Lomas DA, Agusti A, Celli BR, Black-Shinn JL, Kinney GL, Lutz SM, Hokanson JE, Silverman EK, Washko GR
Quantitative computed tomography measures of pectoralis muscle area and disease severity in chronic obstructive pulmonary disease. A cross-sectional study. Ann Am Thorac Soc. 2014 Mar; 11(3):326-34.
Quantitative computed tomography measures of pectoralis muscle area and disease severity in chronic obstructive pulmonary disease. A cross-sectional study.
Family-based designs. IARC Sci Publ. 2011; (163):261-80.
On rare-variant analysis in population-based designs: decomposing the likelihood to two informative components. Hum Hered. 2013; 76(2):76-85.
On rare-variant analysis in population-based designs: decomposing the likelihood to two informative components.
McDonald ML, Cho MH, Sørheim IC, Lutz SM, Castaldi PJ, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard SI, Wouters EF, Bakke P, Tal-Singer R, Miller BE, Gulsvik A, Casaburi R, Wells JM, Regan EA, Make BJ, Hokanson JE, Lange C, Crapo JD, Beaty TH, Silverman EK, Hersh CP
Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2014 Nov; 51(5):678-87.
Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease.
Juraeva D, Haenisch B, Zapatka M, Frank J, Witt SH, Mühleisen TW, Treutlein J, Strohmaier J, Meier S, Degenhardt F, Giegling I, Ripke S, Leber M, Lange C, Schulze TG, Mössner R, Nenadic I, Sauer H, Rujescu D, Maier W, Børglum A, Ophoff R, Cichon S, Nöthen MM, Rietschel M, Mattheisen M, Brors B
Integrated pathway-based approach identifies association between genomic regions at CTCF and CACNB2 and schizophrenia. PLoS Genet. 2014 Jun; 10(6):e1004345.
Integrated pathway-based approach identifies association between genomic regions at CTCF and CACNB2 and schizophrenia.
Kaufmann SH, Lange C, Rao M, Balaji KN, Lotze M, Schito M, Zumla AI, Maeurer M
Progress in tuberculosis vaccine development and host-directed therapies--a state of the art review. Lancet Respir Med. 2014 Apr; 2(4):301-20.
Progress in tuberculosis vaccine development and host-directed therapies--a state of the art review.
Herzmann C, Ernst M, Lange C, Stenger S, Kaufmann SHE, Reiling N, Schaberg T, van der Merwe L, Maertzdorf J
Pulmonary immune responses to Mycobacterium tuberculosis in exposed individuals. PLoS One. 2017; 12(11):e0187882.
Pulmonary immune responses to Mycobacterium tuberculosis in exposed individuals.
Ezewudo M, Borens A, Chiner-Oms Á, Miotto P, Chindelevitch L, Starks AM, Hanna D, Liwski R, Zignol M, Gilpin C, Niemann S, Kohl TA, Warren RM, Crook D, Gagneux S, Hoffner S, Rodrigues C, Comas I, Engelthaler DM, Alland D, Rigouts L, Lange C, Dheda K, Hasan R, McNerney R, Cirillo DM, Schito M, Rodwell TC, Posey J
Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase. Sci Rep. 2018 10 18; 8(1):15382.
Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.
Chesov E, Chesov D, Maurer FP, Andres S, Utpatel C, Barilar I, Donica A, Reimann M, Niemann S, Lange C, Crudu V, Heyckendorf J, Merker M
Emergence of bedaquiline resistance in a high tuberculosis burden country. Eur Respir J. 2022 03; 59(3).
Emergence of bedaquiline resistance in a high tuberculosis burden country.
Guglielmetti L, Günther G, Leu C, Cirillo D, Duarte R, Garcia-Basteiro AL, Goletti D, Jankovic M, Kuksa L, Maurer FP, Méchaï F, Tiberi S, van Leth F, Veziris N, Lange C
Rifapentine access in Europe: growing concerns over key tuberculosis treatment component. Eur Respir J. 2022 05; 59(5).
Rifapentine access in Europe: growing concerns over key tuberculosis treatment component.
Reimann M, Avsar K, DiNardo AR, Goldmann T, Günther G, Hoelscher M, Ibraim E, Kalsdorf B, Kaufmann SHE, Köhler N, Mandalakas AM, Maurer FP, Müller M, Nitschkowski D, Olaru ID, Popa C, Rachow A, Rolling T, Salzer HJF, Sanchez-Carballo P, Schuhmann M, Schaub D, Spinu V, Terhalle E, Unnewehr M, Zielinski NJ, Heyckendorf J, Lange C
The TB27 Transcriptomic Model for Predicting Mycobacterium tuberculosis Culture Conversion. Pathog Immun. 2024; 10(1):120-139.
The TB27 Transcriptomic Model for Predicting Mycobacterium tuberculosis Culture Conversion.
Pichlo S, Carballo PS, Reimann M, Zielinski N, Shuaib YA, Köhler N, Andres S, Heyckendorf J, Kalsdorf B, Olaru ID, Salzer HJF, Lange C
Lipoarabinomannan (LAM) for the diagnosis of tuberculosis from sputum. J Infect. 2025 Dec; 91(6):106662.
Lipoarabinomannan (LAM) for the diagnosis of tuberculosis from sputum.
Castanho I, Naderi Yeganeh P, Boix CA, Morgan SL, Mathys H, Prokopenko D, White B, Soto LM, Pegoraro G, Shah S, Ploumakis A, Kalavros N, Bennett DA, Lange C, Kim DY, Bertram L, Tsai LH, Kellis M, Tanzi RE, Hide W
Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer's disease. Mol Neurodegener. 2025 Oct 01; 20(1):103.
Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer's disease.
de Visser V, Sotgiu G, Lange C, Aabye MG, Bakker M, Bartalesi F, Brat K, Chee CB, Dheda K, Dominguez J, Eyuboglu F, Ghanem M, Goletti D, Dilektasli AG, Guglielmetti L, Koh WJ, Latorre I, Losi M, Polanova M, Ravn P, Ringshausen FC, Rumetshofer R, de Souza-Galvão ML, Thijsen S, Bothamley G, Bossink A
False-negative interferon-? release assay results in active tuberculosis: a TBNET study. Eur Respir J. 2015 Jan; 45(1):279-83.
False-negative interferon-? release assay results in active tuberculosis: a TBNET study.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Tuberculosis preventive chemotherapy: the times they are a-changin'. Int J Tuberc Lung Dis. 2015 Sep; 19(9):1002.
Tuberculosis preventive chemotherapy: the times they are a-changin'.
Blauenfeldt T, Wagner D, Aabye M, Heyckendorf J, Lange B, Lange C, Ernst M, Ravn P, Duarte R, Morais C, Hoffmann M, Schoch OD, Dominguez J, Latorre I, Ruhwald M
Thermostability of IFN-? and IP-10 release assays for latent infection with Mycobacterium tuberculosis: A TBnet study. Tuberculosis (Edinb). 2016 05; 98:7-12.
Thermostability of IFN-? and IP-10 release assays for latent infection with Mycobacterium tuberculosis: A TBnet study.
Herzmann C, Sotgiu G, Schaberg T, Ernst M, Stenger S, Lange C
Childhood BCG vaccination does not influence control of Mycobacterium tuberculosis growth by human bronchoalveolar lavage cells. Tuberculosis (Edinb). 2015 May; 95(3):321-7.
Childhood BCG vaccination does not influence control of Mycobacterium tuberculosis growth by human bronchoalveolar lavage cells.
van Ingen J, Wagner D, Gallagher J, Morimoto K, Lange C, Haworth CS, Floto RA, Adjemian J, Prevots DR, Griffith DE
Poor adherence to management guidelines in nontuberculous mycobacterial pulmonary diseases. Eur Respir J. 2017 02; 49(2).
Poor adherence to management guidelines in nontuberculous mycobacterial pulmonary diseases.
Heyckendorf J, Andres S, Köser CU, Olaru ID, Schön T, Sturegård E, Beckert P, Schleusener V, Kohl TA, Hillemann D, Moradigaravand D, Parkhill J, Peacock SJ, Niemann S, Lange C, Merker M
What Is Resistance? Impact of Phenotypic versus Molecular Drug Resistance Testing on Therapy for Multi- and Extensively Drug-Resistant Tuberculosis. Antimicrob Agents Chemother. 2018 02; 62(2).
What Is Resistance? Impact of Phenotypic versus Molecular Drug Resistance Testing on Therapy for Multi- and Extensively Drug-Resistant Tuberculosis.
Magis-Escurra C, Günther G, Lange C, Alexandru S, Altet N, Avsar K, Bang D, Barbuta R, Bothamley G, Ciobanu A, Crudu V, Davilovits M, Dedicoat M, Duarte R, Gualano G, Kunst H, de Lange W, Leimane V, McLaughlin AM, Muylle I, Polcová V, Popa C, Rumetshofer R, Skrahina A, Solodovnikova V, Spinu V, Tiberi S, Viiklepp P, van Leth F
Treatment outcomes of MDR-TB and HIV co-infection in Europe. Eur Respir J. 2017 06; 49(6).
Treatment outcomes of MDR-TB and HIV co-infection in Europe.
Lange C, Chesov D, Heyckendorf J, Leung CC, Udwadia Z, Dheda K
Drug-resistant tuberculosis: An update on disease burden, diagnosis and treatment. Respirology. 2018 Jul; 23(7):656-673.
Drug-resistant tuberculosis: An update on disease burden, diagnosis and treatment.
Olaru ID, Heyckendorf J, Andres S, Kalsdorf B, Lange C
Bedaquiline-based treatment regimen for multidrug-resistant tuberculosis. Eur Respir J. 2017 05; 49(5).
Bedaquiline-based treatment regimen for multidrug-resistant tuberculosis.
Abidi S, Achar J, Assao Neino MM, Bang D, Benedetti A, Brode S, Campbell JR, Casas EC, Conradie F, Dravniece G, du Cros P, Falzon D, Jaramillo E, Kuaban C, Lan Z, Lange C, Li PZ, Makhmudova M, Maug AKJ, Menzies D, Migliori GB, Miller A, Myrzaliev B, Ndjeka N, Noeske J, Parpieva N, Piubello A, Schwoebel V, Sikhondze W, Singla R, Souleymane MB, Trébucq A, Van Deun A, Viney K, Weyer K, Zhang BJ, Ahmad Khan F
Standardised shorter regimens versus individualised longer regimens for rifampin- or multidrug-resistant tuberculosis. Eur Respir J. 2020 03; 55(3).
Standardised shorter regimens versus individualised longer regimens for rifampin- or multidrug-resistant tuberculosis.
Kwak N, Winters N, Campbell JR, Chan ED, Gegia M, Lange C, Lee M, Milanov V, Menzies D, Yim JJ
Changes in treatment for multidrug-resistant tuberculosis according to national income. Eur Respir J. 2020 11; 56(5).
Changes in treatment for multidrug-resistant tuberculosis according to national income.
Bittner S, Engel S, Lange C, Weber MS, Haghikia A, Luessi F, Korn T, Klotz L, Bayas A, Paul F, Heesen C, Stangel M, Wildemann B, Bergh FT, Tackenberg B, Trebst C, Warnke C, Linker R, Kerschensteiner M, Zettl U, Tumani H, Brück W, Meuth SG, Kümpfel T, Hemmer B, Wiendl H, Gold R, Zipp F
[Diagnostics and treatment of tuberculosis under immunotherapy for multiple sclerosis : Current status and recommendations in Germany]. Nervenarzt. 2019 Dec; 90(12):1245-1253.
[Diagnostics and treatment of tuberculosis under immunotherapy for multiple sclerosis : Current status and recommendations in Germany].
Gröschel MI, Walker TM, van der Werf TS, Lange C, Niemann S, Merker M
Pathogen-based precision medicine for drug-resistant tuberculosis. PLoS Pathog. 2018 10; 14(10):e1007297.
Pathogen-based precision medicine for drug-resistant tuberculosis.
Lan Z, Ahmad N, Baghaei P, Barkane L, Benedetti A, Brode SK, Brust JCM, Campbell JR, Chang VWL, Falzon D, Guglielmetti L, Isaakidis P, Kempker RR, Kipiani M, Kuksa L, Lange C, Laniado-Laborín R, Nahid P, Rodrigues D, Singla R, Udwadia ZF, Menzies D
Drug-associated adverse events in the treatment of multidrug-resistant tuberculosis: an individual patient data meta-analysis. Lancet Respir Med. 2020 04; 8(4):383-394.
Drug-associated adverse events in the treatment of multidrug-resistant tuberculosis: an individual patient data meta-analysis.
Lange C, Dheda K, Chesov D, Mandalakas AM, Udwadia Z, Horsburgh CR
Challenging the management of drug-resistant tuberculosis - Authors' reply. Lancet. 2020 03 07; 395(10226):783-784.
Challenging the management of drug-resistant tuberculosis - Authors' reply.
Daley CL, Iaccarino JM, Lange C, Cambau E, Wallace RJ, Andrejak C, Böttger EC, Brozek J, Griffith DE, Guglielmetti L, Huitt GA, Knight SL, Leitman P, Marras TK, Olivier KN, Santin M, Stout JE, Tortoli E, van Ingen J, Wagner D, Winthrop KL
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline. Clin Infect Dis. 2020 08 14; 71(4):905-913.
Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline.
Mika T, Vangala D, Eckhardt M, La Rosée P, Lange C, Lehmberg K, Wohlschläger C, Biskup S, Fuchs I, Mann J, Ehl S, Warnatz K, Schroers R
Case Report: Hemophagocytic Lymphohistiocytosis and Non-Tuberculous Mycobacteriosis Caused by a Novel GATA2 Variant. Front Immunol. 2021; 12:682934.
Case Report: Hemophagocytic Lymphohistiocytosis and Non-Tuberculous Mycobacteriosis Caused by a Novel GATA2 Variant.
Roelens M, Battista Migliori G, Rozanova L, Estill J, Campbell JR, Cegielski JP, Tiberi S, Palmero D, Fox GJ, Guglielmetti L, Sotgiu G, Brust JCM, Bang D, Lienhardt C, Lange C, Menzies D, Keiser O, Raviglione M
Evidence-based Definition for Extensively Drug-Resistant Tuberculosis. Am J Respir Crit Care Med. 2021 09 15; 204(6):713-722.
Evidence-based Definition for Extensively Drug-Resistant Tuberculosis.
Gupta RK, Calderwood CJ, Yavlinsky A, Krutikov M, Quartagno M, Aichelburg MC, Altet N, Diel R, Dobler CC, Dominguez J, Doyle JS, Erkens C, Geis S, Haldar P, Hauri AM, Hermansen T, Johnston JC, Lange C, Lange B, van Leth F, Muñoz L, Roder C, Romanowski K, Roth D, Sester M, Sloot R, Sotgiu G, Woltmann G, Yoshiyama T, Zellweger JP, Zenner D, Aldridge RW, Copas A, Rangaka MX, Lipman M, Noursadeghi M, Abubakar I
Discovery and validation of a personalized risk predictor for incident tuberculosis in low transmission settings. Nat Med. 2020 12; 26(12):1941-1949.
Discovery and validation of a personalized risk predictor for incident tuberculosis in low transmission settings.
Heyckendorf J, Reimann M, Marwitz S, Lange C
Pathogen-free diagnosis of tuberculosis. Lancet Infect Dis. 2021 08; 21(8):1066.
Pathogen-free diagnosis of tuberculosis.
Correa-Macedo W, Fava VM, Orlova M, Cassart P, Olivenstein R, Sanz J, Xu YZ, Dumaine A, Sindeaux RH, Yotova V, Pacis A, Girouard J, Kalsdorf B, Lange C, Routy JP, Barreiro LB, Schurr E
Alveolar macrophages from persons living with HIV show impaired epigenetic response to Mycobacterium tuberculosis. J Clin Invest. 2021 11 15; 131(22).
Alveolar macrophages from persons living with HIV show impaired epigenetic response to Mycobacterium tuberculosis.
Lange C, Böttger EC, Cambau E, Griffith DE, Guglielmetti L, van Ingen J, Knight SL, Marras TK, Olivier KN, Santin M, Stout JE, Tortoli E, Wagner D, Winthrop K, Daley CL
Consensus management recommendations for less common non-tuberculous mycobacterial pulmonary diseases. Lancet Infect Dis. 2022 07; 22(7):e178-e190.
Consensus management recommendations for less common non-tuberculous mycobacterial pulmonary diseases.
Lange C, Aarnoutse R, Chesov D, van Crevel R, Gillespie SH, Grobbel HP, Kalsdorf B, Kontsevaya I, van Laarhoven A, Nishiguchi T, Mandalakas A, Merker M, Niemann S, Köhler N, Heyckendorf J, Reimann M, Ruhwald M, Sanchez-Carballo P, Schwudke D, Waldow F, DiNardo AR
Perspective for Precision Medicine for Tuberculosis. Front Immunol. 2020; 11:566608.
Perspective for Precision Medicine for Tuberculosis.
Sibandze DB, Kay A, Dreyer V, Sikhondze W, Dlamini Q, DiNardo A, Mtetwa G, Lukhele B, Vambe D, Lange C, Glenn Dlamini M, Ness T, Mejia R, Kalsdorf B, Heyckendorf J, Kuhns M, Maurer FP, Dlamini S, Maphalala G, Niemann S, Mandalakas A
Rapid molecular diagnostics of tuberculosis resistance by targeted stool sequencing. Genome Med. 2022 05 19; 14(1):52.
Rapid molecular diagnostics of tuberculosis resistance by targeted stool sequencing.
Kontsevaya I, Lange C, Comella-Del-Barrio P, Coarfa C, DiNardo AR, Gillespie SH, Hauptmann M, Leschczyk C, Mandalakas AM, Martinecz A, Merker M, Niemann S, Reimann M, Rzhepishevska O, Schaible UE, Scheu KM, Schurr E, Abel Zur Wiesch P, Heyckendorf J
European respiratory review : an official journal of the European Respiratory Society
Perspectives for systems biology in the management of tuberculosis. Eur Respir Rev. 2021 Jun 30; 30(160).
Perspectives for systems biology in the management of tuberculosis.
DiNardo AR, Gandhi T, Heyckendorf J, Grimm SL, Rajapakshe K, Nishiguchi T, Reimann M, Kirchner HL, Kahari J, Dlamini Q, Lange C, Goldmann T, Marwitz S, Cirillo JD, Kaufmann SHE, Netea MG, van Crevel R, Mandalakas AM, Coarfa C
Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes. Eur Respir J. 2022 09; 60(3).
Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes.
Maier C, Chesov D, Schaub D, Kalsdorf B, Andres S, Friesen I, Reimann M, Lange C
Long-term treatment outcomes in patients with multidrug-resistant tuberculosis. Clin Microbiol Infect. 2023 Jun; 29(6):751-757.
Long-term treatment outcomes in patients with multidrug-resistant tuberculosis.
Otto-Knapp R, Häcker B, Krieger D, Stete K, Starzacher K, Maier C, Heyckendorf J, Avsar K, Suárez I, Rybniker J, Bauer T, Günther G, Lange C
Long-term multidrug- and rifampicin-resistant tuberculosis treatment outcome by new WHO definitions in Germany. Eur Respir J. 2022 11; 60(5).
Long-term multidrug- and rifampicin-resistant tuberculosis treatment outcome by new WHO definitions in Germany.
Tran F, Harris DMM, Scharmacher A, Graßhoff H, Sterner K, Schinke S, Käding N, Humrich JY, Cabral-Marques O, Bernardes JP, Mishra N, Bahmer T, Franzenburg J, Hoyer BF, Glück A, Guggeis M, Ossysek A, Küller A, Frank D, Lange C, Rupp J, Heyckendorf J, Gaede KI, Amital H, Rosenstiel P, Shoenfeld Y, Halpert G, Rosenberg AZ, Schulze-Forster K, Heidecke H, Riemekasten G, Schreiber S
Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19. ERJ Open Res. 2022 Oct; 8(4).
Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19.
Treatments of Multidrug-Resistant Tuberculosis: Light at the End of the Tunnel. Am J Respir Crit Care Med. 2022 05 15; 205(10):1142-1144.
Treatments of Multidrug-Resistant Tuberculosis: Light at the End of the Tunnel.
Villar-Hernández R, Ghodousi A, Konstantynovska O, Duarte R, Lange C, Raviglione M
Tuberculosis: current challenges and beyond. Breathe (Sheff). 2023 Mar; 19(1):220166.
Tuberculosis: current challenges and beyond.
Saluzzo F, Adepoju VA, Duarte R, Lange C, Phillips PPJ
Treatment-shortening regimens for tuberculosis: updates and future priorities. Breathe (Sheff). 2023 Sep; 19(3):230028.
Treatment-shortening regimens for tuberculosis: updates and future priorities.
Koehler N, Andres S, Merker M, Dreyer V, John A, Kuhns M, Krieger D, Choong E, Verougstraete N, Zur Wiesch PA, Wicha SG, König C, Kalsdorf B, Sanchez Carballo PM, Schaub D, Werngren J, Schön T, Peloquin CA, Schönfeld N, Verstraete AG, Decosterd LA, Aarnoutse R, Niemann S, Maurer FP, Lange C
Pretomanid-resistant tuberculosis. J Infect. 2023 05; 86(5):520-524.
Hamada Y, Gupta RK, Quartagno M, Izzard A, Acuna-Villaorduna C, Altet N, Diel R, Dominguez J, Floyd S, Gupta A, Huerga H, Jones-López EC, Kinikar A, Lange C, van Leth F, Liu Q, Lu W, Lu P, Rueda IL, Martinez L, Mbandi SK, Muñoz L, Padilla ES, Paradkar M, Scriba T, Sester M, Shanaube K, Sharma SK, Sloot R, Sotgiu G, Thiruvengadam K, Vashishtha R, Abubakar I, Rangaka MX
Predictive performance of interferon-gamma release assays and the tuberculin skin test for incident tuberculosis: an individual participant data meta-analysis. EClinicalMedicine. 2023 Feb; 56:101815.
Predictive performance of interferon-gamma release assays and the tuberculin skin test for incident tuberculosis: an individual participant data meta-analysis.
Otto-Knapp R, Bauer T, Brinkmann F, Feiterna-Sperling C, Friesen I, Geerdes-Fenge H, Hartmann P, Häcker B, Heyckendorf J, Kuhns M, Lange C, Maurer FP, Nienhaus A, Priwitzer M, Richter E, Salzer HJF, Schoch OD, Schönfeld N, Schaberg T
Respiration; international review of thoracic diseases
Treatment of MDR, Pre-XDR, XDR, and Rifampicin-Resistant Tuberculosis or in Case of Intolerance to at Least Rifampicin in Austria, Germany, and Switzerland. Respiration. 2024; 103(9):593-600.
Treatment of MDR, Pre-XDR, XDR, and Rifampicin-Resistant Tuberculosis or in Case of Intolerance to at Least Rifampicin in Austria, Germany, and Switzerland.
Kontsevaya I, Heyckendorf J, Koops F, Hillemann D, Goldmann T, Upton CM, De Jager V, Diacon A, Lange C
Transrenal Mycobacterium tuberculosis DNA in pulmonary tuberculosis patients during the first 14 days of treatment. Microbiol Spectr. 2023 12 12; 11(6):e0234823.
Transrenal Mycobacterium tuberculosis DNA in pulmonary tuberculosis patients during the first 14 days of treatment.
Lange C, Kherabi Y, Guglielmetti L, Duarte R, Günther G
Availability of drugs and resistance testing for bedaquiline, pretomanid, linezolid, and moxifloxacin (BPaL(M)) regimen for rifampicin-resistant tuberculosis in Europe: author's response. Clin Microbiol Infect. 2024 Sep; 30(9):1207-1208.
Availability of drugs and resistance testing for bedaquiline, pretomanid, linezolid, and moxifloxacin (BPaL(M)) regimen for rifampicin-resistant tuberculosis in Europe: author's response.
Köhler N, Karaköse H, Grobbel HP, Hillemann D, Andres S, König C, Kalsdorf B, Brehm TT, Böttcher L, Friesen I, Hoffmann H, Strelec D, Schaub D, Peloquin CA, Schmiedel S, Decosterd LA, Choong E, Wicha SG, Aarnoutse RE, Lange C, Sánchez Carballo PM
A Single-Run HPLC-MS Multiplex Assay for Therapeutic Drug Monitoring of Relevant First- and Second-Line Antibiotics in the Treatment of Drug-Resistant Tuberculosis. Pharmaceutics. 2023 Oct 27; 15(11).
A Single-Run HPLC-MS Multiplex Assay for Therapeutic Drug Monitoring of Relevant First- and Second-Line Antibiotics in the Treatment of Drug-Resistant Tuberculosis.
McClean M, Panciu TC, Lange C, Duarte R, Theis F
Artificial intelligence in tuberculosis: a new ally in disease control. Breathe (Sheff). 2024 Oct; 20(3):240056.
Artificial intelligence in tuberculosis: a new ally in disease control.
Fischer C, Siakavara M, Alter P, Vogelmeier CF, Speicher T, Pott H, Watz H, Bals R, Trudzinski F, Herth F, Ficker JH, Wagner M, Lange C, Stoycheva K, Randerath W, Behr J, Fähndrich S, Welte T, Pink I, Kahnert K, Seeger W, Kuhnert S, Gessler T, Adaskina N, Jörres RA
Association of Patients' Knowledge on the Disease and Its Management with Indicators of Disease Severity and Individual Characteristics in Patients with Chronic Obstructive Pulmonary Disease (COPD): Results from COSYCONET 2. Patient Prefer Adherence. 2024; 18:2383-2393.
Association of Patients' Knowledge on the Disease and Its Management with Indicators of Disease Severity and Individual Characteristics in Patients with Chronic Obstructive Pulmonary Disease (COPD): Results from COSYCONET 2.
Carratala-Castro L, Ssengooba W, Kay A, Acácio S, Ehrlich J, DiNardo AR, Shiba N, Nsubuga JK, Munguambe S, Saavedra-Cervera B, Manjate P, Mulengwa D, Sibandze B, Ziyane M, Kasule G, Mambuque E, Sekadde MP, Wobudeya E, Joloba ML, Heyckendorf J, Lange C, Hermans S, Mandalakas A, García-Basteiro AL, Lopez-Varela E
A stool based qPCR for the diagnosis of TB in children and people living with HIV in Uganda, Eswatini and Mozambique (Stool4TB): a protocol for a multicenter diagnostic evaluation. BMC Infect Dis. 2024 Feb 21; 24(1):233.
A stool based qPCR for the diagnosis of TB in children and people living with HIV in Uganda, Eswatini and Mozambique (Stool4TB): a protocol for a multicenter diagnostic evaluation.
Towards shorter, safer, flexible, and more effective treatment regimens for drug-resistant tuberculosis. Lancet Respir Med. 2024 Dec; 12(12):939-941.
Towards shorter, safer, flexible, and more effective treatment regimens for drug-resistant tuberculosis.
Lange C, Mandalakas AM, Lillebaek T, Chesov D, Dheda K, Saluzzo F
Revisiting diagnostics: high priority tuberculosis diagnostic tests that fill an unmet need: what we need and what we do not need. Clin Microbiol Infect. 2025 Mar; 31(3):312-314.
Revisiting diagnostics: high priority tuberculosis diagnostic tests that fill an unmet need: what we need and what we do not need.
Kunst H, Lange B, Hovardovska O, Bockey A, Zenner D, Andersen AB, Hargreaves S, Pareek M, Friedland JS, Wejse C, Bothamley G, Guglielmetti L, Chesov D, Tiberi S, Matteelli A, Mandalakas AM, Heyckendorf J, Eimer J, Malhotra A, Zamora J, Vasiliu A, Lange C
Tuberculosis in adult migrants in Europe: a TBnet consensus statement. Eur Respir J. 2025 Mar; 65(3).
Tuberculosis in adult migrants in Europe: a TBnet consensus statement.
Preventive chemotherapy for contacts of MDR-TB: is the proof in the pudding? Int J Tuberc Lung Dis. 2014 Nov; 18(11):1262-3.
Preventive chemotherapy for contacts of MDR-TB: is the proof in the pudding?
Loebinger MR, Aliberti S, Haworth C, Jankovic Makek M, Lange C, Lorent N, Papavasileiou A, Polverino E, Rohde G, Veziris N, Wagner D, van Ingen J
Patients at risk of nontuberculous mycobacterial pulmonary disease who need testing evaluated using a modified Delphi process by European experts. ERJ Open Res. 2024 Sep; 10(5).
Patients at risk of nontuberculous mycobacterial pulmonary disease who need testing evaluated using a modified Delphi process by European experts.
Budde K, Lange C, Reimann M, Zielinski N, Meiwes L, Köhler N, Carballo PS
A novel method for detecting Lipoarabinomannan in urine with the promise of meeting the WHO target product profile for the diagnosis of tuberculosis. Tuberculosis (Edinb). 2025 May; 152:102619.
A novel method for detecting Lipoarabinomannan in urine with the promise of meeting the WHO target product profile for the diagnosis of tuberculosis.
Stoycheva K, Cristea V, Ködmön C, Rosales-Klintz S, Zenner D, Vasiliu A, van der Werf M, Lange C
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
Tuberculosis in people of Ukrainian origin in the European Union and the European Economic Area, 2019 to 2022. Euro Surveill. 2024 Mar; 29(12).
Tuberculosis in people of Ukrainian origin in the European Union and the European Economic Area, 2019 to 2022.
Vasiliu A, Carratala-Castro L, Seeger A, Ehrlich J, Nkala B, Ness T, Cumbe MM, Mulengwa D, Munguambe S, Mtafya B, Mambuque E, Shiba N, Acacio S, Komba L, Adu-Gyamfi CG, Kirchner HL, Lange C, DiNardo AR, Garcia-Basteiro AL, Mandalakas AM, Kay A
Journal of the Pediatric Infectious Diseases Society
Performance of a Novel Stool Quantitative Polymerase Chain Reaction Assay for Pediatric Tuberculosis Detection in Sub-Saharan Africa. J Pediatric Infect Dis Soc. 2025 Jun 16; 14(6).
Performance of a Novel Stool Quantitative Polymerase Chain Reaction Assay for Pediatric Tuberculosis Detection in Sub-Saharan Africa.
Zielinski N, Baiceanu D, Dragomir A, Heyckendorf J, Ibraim E, Köhler N, Leschczyk C, Popa C, Rachow A, Sachsenweger J, Sanchez Carballo P, Schaub D, Zeeb H, Tulu B, DiNardo AR, Lange C, Reimann M
A Transcriptomic Biomarker Predicting Linezolid-Associated Neuropathy During Treatment of Drug-Resistant Tuberculosis. Pathog Immun. 2024; 9(2):25-42.
A Transcriptomic Biomarker Predicting Linezolid-Associated Neuropathy During Treatment of Drug-Resistant Tuberculosis.
Hoelscher M, Barros-Aguirre D, Dara M, Heinrich N, Sun E, Lange C, Tiberi S, Wells C
Candidate anti-tuberculosis medicines and regimens under clinical evaluation. Clin Microbiol Infect. 2024 Sep; 30(9):1131-1138.
Candidate anti-tuberculosis medicines and regimens under clinical evaluation.
Schildkraut JA, Köhler N, Lange C, Duarte R, Gillespie SH
Advances in tuberculosis biomarkers: unravelling risk factors, active disease and treatment success. Breathe (Sheff). 2024 Oct; 20(3):240003.
Advances in tuberculosis biomarkers: unravelling risk factors, active disease and treatment success.
Youngquist BM, Saliba J, Kim Y, Cutro TJ, Lyon CJ, Olivo J, Ha N, Fine J, Colman R, Vergara C, Robinson J, LaCourse S, Garfein RS, Catanzaro DG, Lange C, Perez-Then E, Graviss EA, Mitchell CD, Rodwell T, Ning B, Hu TY
Rapid tuberculosis diagnosis from respiratory or blood samples by a low cost, portable lab-in-tube assay. Sci Transl Med. 2025 Apr 09; 17(793):eadp6411.
Rapid tuberculosis diagnosis from respiratory or blood samples by a low cost, portable lab-in-tube assay.
Kasule GW, Hermans S, Acacio S, Kay A, Nsubuga JK, Fernández-Escobar C, Shiba N, Carratalá-Castro L, Semugenze D, Mwachan P, Munguambe S, Ehrlich J, Lopez-Varela E, DiNardo AR, Cobelens F, Lange C, Joloba M, Mandalakas AM, Ssengooba W, García-Basteiro AL
Performance of stool Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis among adults living with HIV: a multicentre, prospective diagnostic study. Lancet Microbe. 2025 Jul; 6(7):101085.
Performance of stool Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis among adults living with HIV: a multicentre, prospective diagnostic study.
Belheouane M, Kalsdorf B, Niemann S, Gaede KI, Lange C, Heyckendorf J, Merker M
Serratia sp. traits distinguish the lung microbiome of patients with tuberculosis and non-tuberculous mycobacterial lung diseases. PLoS One. 2025; 20(6):e0325362.
Serratia sp. traits distinguish the lung microbiome of patients with tuberculosis and non-tuberculous mycobacterial lung diseases.
Vasiliu A, Cristea V, Stoycheva K, Rosales-Klintz S, Lange C, Zenner D, Ködmön C
Shifting tuberculosis dynamics in the EU/EEA: geographical and drug resistance trends among people of foreign origin, 2019 to 2023. Euro Surveill. 2025 Mar; 30(11).
Shifting tuberculosis dynamics in the EU/EEA: geographical and drug resistance trends among people of foreign origin, 2019 to 2023.
Linezolid for the treatment of drug-resistant tuberculosis. Eur Respir J. 2025 Aug; 66(2).
Linezolid for the treatment of drug-resistant tuberculosis.
Sester M, Altet-Gomez N, Andersen ÅB, Arias-Guillén M, Avsar K, Bakken Kran AM, Bothamley G, Nordholm Breschel AC, Brown J, Chesov D, Ciobanu N, Cirillo DM, Crudu V, de Souza Galvao M, Dilektasli AG, Dominguez J, Duarte R, Dyrhol-Riise AM, Goletti D, Hoffmann H, Ibraim E, Kalsdorf B, Krawczyk M, Kunst H, Lange B, Lipman M, Matteelli A, Milkiewicz P, Neyer D, Nitschke M, Oral HB, Palacios-Gutiérrez JJ, Petruccioli E, Raszeja-Wyszomirska J, Ravn P, Rupp J, Spohn HE, Toader C, Villar-Hernandez R, Wagner D, van Leth F, Martinez L, Pedersen OS, Lange C
Diagnostic accuracy and predictive value of the QuantiFERON-TB gold plus assay for tuberculosis in immunocompromised individuals: a prospective TBnet study. Lancet Reg Health Eur. 2025 Oct; 57:101416.
Diagnostic accuracy and predictive value of the QuantiFERON-TB gold plus assay for tuberculosis in immunocompromised individuals: a prospective TBnet study.
Chesov D, Reimann M, Mukherjee T, Tewatia K, Konstantynovska O, David A, Rusu D, Ciobanu N, Crudu V, Lange C
High rates of acquired resistance to fluoroquinolones, bedaquiline, and linezolid in patients failing treatment against drug-resistant tuberculosis in the Republic of Moldova. Clin Microbiol Infect. 2026 Jan; 32(1):177-180.
High rates of acquired resistance to fluoroquinolones, bedaquiline, and linezolid in patients failing treatment against drug-resistant tuberculosis in the Republic of Moldova.
Voorhies K, Fiedorowicz JG, Yohannes AM, Kinney GL, DeMeo DL, Regan EA, Crapo JD, Silverman EK, Lange C, Hoth KF, Lutz SM
Factors associated with new onset of depression and anxiety symptoms differ by sex in the COPDGene study. J Psychosom Res. 2025 Oct; 197:112345.
Factors associated with new onset of depression and anxiety symptoms differ by sex in the COPDGene study.
Carratalà Castro L, Munguambe S, Kay A, Ssengooba W, Mulengwa D, Acácio S, Ehrlich J, DiNardo AR, Vasiliu A, Seeger A, Mambuque E, Adu-Gyamfi CG, Timoteo H, Lange C, Hermans S, Mandalakas A, López-Varela E, García-Basteiro AL
Estimating the Accuracy and Additionality of TB-LAM to Diagnose TB in Children Without HIV (AccuLAM). Clin Infect Dis. 2026 Feb 25; 82(2):301-303.
Estimating the Accuracy and Additionality of TB-LAM to Diagnose TB in Children Without HIV (AccuLAM).
Ness TE, Ziyane M, Maphalala N, Seeger A, Vasiliu A, Khumalo W, Thunzini M, Dlamini S, Maphalala G, Gascua C, Lange C, Meyer S, Inman B, Dreyer V, Utpatel C, Niemann T, DiNardo A, Kay A, Niemann S, Mandalakas A
Screening and targeted sequencing of stool for microbiologic confirmation and drug resistance determination in paucibacillary tuberculosis. PLOS Glob Public Health. 2025; 5(11):e0005243.
Screening and targeted sequencing of stool for microbiologic confirmation and drug resistance determination in paucibacillary tuberculosis.
Olaru ID, von Groote-Bidlingmaier F, Heyckendorf J, Yew WW, Lange C, Chang KC
Novel drugs against tuberculosis: a clinician's perspective. Eur Respir J. 2015 Apr; 45(4):1119-31.
Novel drugs against tuberculosis: a clinician's perspective.
Correction to Diagnostic accuracy and predictive value of the QuantiFERON-TB gold plus assay for tuberculosis in immunocompromised individuals: a prospective TBnet study Lancet Reg Health Eur 57 (2025) 101416 LLRHEUROPE-D-25-00310. Lancet Reg Health Eur. 2025 Dec; 59:101523.
Correction to Diagnostic accuracy and predictive value of the QuantiFERON-TB gold plus assay for tuberculosis in immunocompromised individuals: a prospective TBnet study Lancet Reg Health Eur 57 (2025) 101416 LLRHEUROPE-D-25-00310.
Editorial Commentary: 1, 2, 3 (Years)??…??and You're Out: The End of a 123-year Historic Era. Clin Infect Dis. 2016 May 01; 62(9):1089-91.
Editorial Commentary: 1, 2, 3 (Years)??…??and You're Out: The End of a 123-year Historic Era.
Lange B, Brehm TT, Arend SM, Arias-Guillén M, Bakker M, Berastegui C, Babiker M, Charif R, Duarte R, Flick H, Hofland RW, Ismail J, Kniepeiss D, Krepel J, Krishnan N, Kuijpers DL, Kunst H, van Leth F, Lezaic V, Los-Arcos I, Machová J, Milburn H, Morais SA, Kon OM, Osoro-Suarez C, Pessegueiro Miranda H, Pesut D, Rahman A, Reischig T, Sánchez-Montalvá A, Spohn HE, Stegenga MT, de Vries APJ, Wagner D, Wobser R, Lange C, Sester M
Tuberculosis incidence in solid organ transplant recipients in Europe: A multicenter TBnet cohort study. J Infect. 2026 Jan; 92(1):106668.
Tuberculosis incidence in solid organ transplant recipients in Europe: A multicenter TBnet cohort study.
Parida SK, Poiret T, Zhenjiang L, Meng Q, Heyckendorf J, Lange C, Ambati AS, Rao MV, Valentini D, Ferrara G, Rangelova E, Dodoo E, Zumla A, Maeurer M
T-Cell Therapy: Options for Infectious Diseases. Clin Infect Dis. 2015 Oct 15; 61Suppl 3:S217-24.
T-Cell Therapy: Options for Infectious Diseases.
Herzmann C, Sotgiu G, Bellinger O, Diel R, Gerdes S, Goetsch U, Heykes-Uden H, Schaberg T, Lange C
Risk for latent and active tuberculosis in Germany. Infection. 2017 Jun; 45(3):283-290.
Risk for latent and active tuberculosis in Germany.
Heyckendorf J, Labugger I, van der Merwe L, Garcia-Basteiro AL, Diacon AH, Lange C
Serial measurements of transrenal mycobacterial DNA as indicators of the early bactericidal activity (EBA) of antituberculosis drugs. Tuberculosis (Edinb). 2017 01; 102:31-33.
Serial measurements of transrenal mycobacterial DNA as indicators of the early bactericidal activity (EBA) of antituberculosis drugs.
Dedicoat MJ, Günther G, Crudu V, Duarte R, Gualano G, Magis-Escurra C, Rumetshofer R, Skrahina A, Spinu V, Tiberi S, Viiklepp P, van Leth F, Lange C
Tuberculosis Treatment Outcomes in Europe: Based on Treatment Completion, Not Cure. Am J Respir Crit Care Med. 2017 11 01; 196(9):1222-1224.
Tuberculosis Treatment Outcomes in Europe: Based on Treatment Completion, Not Cure.
Heyckendorf J, van Leth F, Kalsdorf B, Olaru ID, Günther G, Salzer HJF, Terhalle E, Rolling T, Glattki G, Müller M, Schuhmann M, Avsar K, Lange C
Relapse-free cure from multidrug-resistant tuberculosis in Germany. Eur Respir J. 2018 02; 51(2).
Relapse-free cure from multidrug-resistant tuberculosis in Germany.
Salzer HJF, Burchard G, Cornely OA, Lange C, Rolling T, Schmiedel S, Libman M, Capone D, Le T, Dalcolmo MP, Heyckendorf J
Diagnosis and Management of Systemic Endemic Mycoses Causing Pulmonary Disease. Respiration. 2018; 96(3):283-301.
Diagnosis and Management of Systemic Endemic Mycoses Causing Pulmonary Disease.
De Pascale G, Ranzani OT, Nseir S, Chastre J, Welte T, Antonelli M, Navalesi P, Garofalo E, Bruni A, Coelho LM, Skoczynski S, Longhini F, Taccone FS, Grimaldi D, Salzer HJF, Lange C, Froes F, Artigas A, Díaz E, Vallés J, Rodríguez A, Panigada M, Comellini V, Fasano L, Soave PM, Spinazzola G, Luyt CE, Alvarez-Lerma F, Marin J, Masclans JR, Chiumello D, Pezzi A, Schultz M, Mohamed H, Van Der Eerden M, Hoek RAS, Gommers DAMPJ, Pasquale MD, Civljak R, Kutleša M, Bassetti M, Dimopoulos G, Nava S, Rios F, Zampieri FG, Povoa P, Bos LD, Aliberti S, Torres A, Martín-Loeches I
Intensive care unit patients with lower respiratory tract nosocomial infections: the ENIRRIs project. ERJ Open Res. 2017 Oct; 3(4).
Intensive care unit patients with lower respiratory tract nosocomial infections: the ENIRRIs project.
Merker M, Crudu V, Noroc E, Romancenco E, Chesov D, Günther G, Niemann S, Lange C
In reply. Int J Tuberc Lung Dis. 2016 Mar; 20(3):424.
Salzer HJF, Heyckendorf J, Kalsdorf B, Herzmann C, Hoffmann C, Lange C
Chronic Cough and Severe Weight Loss in a 55-Year-Old Previously Healthy Man. Clin Infect Dis. 2017 07 15; 65(2):349-351.
Chronic Cough and Severe Weight Loss in a 55-Year-Old Previously Healthy Man.
Sane Schepisi M, Navarra A, Altet Gomez MN, Dudnyk A, Dyrhol-Riise AM, Esteban J, Giorgetti PF, Gualano G, Guglielmetti L, Heyckendorf J, Kaluzhenina A, Lange B, Lange C, Manika K, Miah J, Nanovic Z, Pontali E, Prego MR, Solovic I, Tiberi S, Palmieri F, Girardi E
Burden and Characteristics of the Comorbidity Tuberculosis-Diabetes in Europe: TBnet Prevalence Survey and Case-Control Study. Open Forum Infect Dis. 2019 Jan; 6(1):ofy337.
Burden and Characteristics of the Comorbidity Tuberculosis-Diabetes in Europe: TBnet Prevalence Survey and Case-Control Study.
Guglielmetti L, Tiberi S, Burman M, Kunst H, Wejse C, Togonidze T, Bothamley G, Lange C
QT prolongation and cardiac toxicity of new tuberculosis drugs in Europe: a Tuberculosis Network European Trialsgroup (TBnet) study. Eur Respir J. 2018 08; 52(2).
QT prolongation and cardiac toxicity of new tuberculosis drugs in Europe: a Tuberculosis Network European Trialsgroup (TBnet) study.
Alastruey-Izquierdo A, Cadranel J, Flick H, Godet C, Hennequin C, Hoenigl M, Kosmidis C, Lange C, Munteanu O, Page I, Salzer HJF
Treatment of Chronic Pulmonary Aspergillosis: Current Standards and Future Perspectives. Respiration. 2018; 96(2):159-170.
Treatment of Chronic Pulmonary Aspergillosis: Current Standards and Future Perspectives.
Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline. Clin Infect Dis. 2020 08 14; 71(4):e1-e36.
Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS/ERS/ESCMID/IDSA clinical practice guideline. Eur Respir J. 2020 07; 56(1).
Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS/ERS/ESCMID/IDSA clinical practice guideline.
Köser CU, Heyckendorf J, Andres S, Olaru ID, Schön T, Sturegård E, Beckert P, Schleusener V, Kohl TA, Hillemann D, Moradigaravand D, Parkhill J, Peacock SJ, Niemann S, Lange C, Merker M
Reply to Dookie et al., "Whole-Genome Sequencing To Guide the Selection of Treatment for Drug-Resistant Tuberculosis". Antimicrob Agents Chemother. 2018 08; 62(8).
Reply to Dookie et al., "Whole-Genome Sequencing To Guide the Selection of Treatment for Drug-Resistant Tuberculosis".
Author Correction: Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase. Sci Rep. 2020 Feb 21; 10(1):3531.
Author Correction: Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.
Vahdati S, Fathalla S, Lange C, Behrend A, Say A, Say Z, Auer S
A comprehensive quality assessment framework for scientific events. Scientometrics. 2021; 126(1):641-682.
A comprehensive quality assessment framework for scientific events.
Lange C, Chesov D, Konstantynovska O, Mandalakas AM, Udwadia Z
Sorry for the delay. Clin Microbiol Infect. 2021 07; 27(7):941-943.
Grobbel HP, Merker M, Köhler N, Andres S, Hoffmann H, Heyckendorf J, Reimann M, Barilar I, Dreyer V, Hillemann D, Kalsdorf B, Kohl TA, Sanchez Carballo P, Schaub D, Todt K, Utpatel C, Maurer FP, Lange C, Niemann S
Design of Multidrug-Resistant Tuberculosis Treatment Regimens Based on DNA Sequencing. Clin Infect Dis. 2021 10 05; 73(7):1194-1202.
Design of Multidrug-Resistant Tuberculosis Treatment Regimens Based on DNA Sequencing.
Bernardes JP, Mishra N, Tran F, Bahmer T, Best L, Blase JI, Bordoni D, Franzenburg J, Geisen U, Josephs-Spaulding J, Köhler P, Künstner A, Rosati E, Aschenbrenner AC, Bacher P, Baran N, Boysen T, Brandt B, Bruse N, Dörr J, Dräger A, Elke G, Ellinghaus D, Fischer J, Forster M, Franke A, Franzenburg S, Frey N, Friedrichs A, Fuß J, Glück A, Hamm J, Hinrichsen F, Hoeppner MP, Imm S, Junker R, Kaiser S, Kan YH, Knoll R, Lange C, Laue G, Lier C, Lindner M, Marinos G, Markewitz R, Nattermann J, Noth R, Pickkers P, Rabe KF, Renz A, Röcken C, Rupp J, Schaffarzyk A, Scheffold A, Schulte-Schrepping J, Schunk D, Skowasch D, Ulas T, Wandinger KP, Wittig M, Zimmermann J, Busch H, Hoyer BF, Kaleta C, Heyckendorf J, Kox M, Rybniker J, Schreiber S, Schultze JL, Rosenstiel P
Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19. Immunity. 2020 12 15; 53(6):1296-1314.e9.
Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19.
Management of drug-resistant tuberculosis. Lancet. 2019 09 14; 394(10202):953-966.
Management of drug-resistant tuberculosis.
Salzer HJF, Massango I, Bhatt N, Machonisse E, Reimann M, Heldt S, Lange C, Hoelscher M, Khosa C, Rachow A
Seroprevalence of Aspergillus-Specific IgG Antibody among Mozambican Tuberculosis Patients. J Fungi (Basel). 2021 Jul 23; 7(8).
Seroprevalence of Aspergillus-Specific IgG Antibody among Mozambican Tuberculosis Patients.
Mandalakas AM, Hesseling AC, Kay A, Du Preez K, Martinez L, Ronge L, DiNardo A, Lange C, Kirchner HL
Tuberculosis prevention in children: a prospective community-based study in South Africa. Eur Respir J. 2021 04; 57(4).
Tuberculosis prevention in children: a prospective community-based study in South Africa.
Brandenburg J, Marwitz S, Tazoll SC, Waldow F, Kalsdorf B, Vierbuchen T, Scholzen T, Gross A, Goldenbaum S, Hölscher A, Hein M, Linnemann L, Reimann M, Kispert A, Leitges M, Rupp J, Lange C, Niemann S, Behrends J, Goldmann T, Heine H, Schaible UE, Hölscher C, Schwudke D, Reiling N
WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis. J Clin Invest. 2021 08 16; 131(16).
WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis.
Van Braeckel E, Page I, Davidsen JR, Laursen CB, Agarwal R, Alastruey-Izquierdo A, Barac A, Cadranel J, Chakrabarti A, Cornely OA, Denning DW, Flick H, Gangneux JP, Godet C, Hayashi Y, Hennequin C, Hoenigl M, Irfan M, Izumikawa K, Koh WJ, Kosmidis C, Lange C, Lamprecht B, Laurent F, Munteanu O, Oladele R, Patterson TF, Watanabe A, Salzer HJF
Treatment outcome definitions in chronic pulmonary aspergillosis: a CPAnet consensus statement. Eur Respir J. 2022 06; 59(6).
Treatment outcome definitions in chronic pulmonary aspergillosis: a CPAnet consensus statement.
Heyckendorf J, Marwitz S, Reimann M, Avsar K, DiNardo AR, Günther G, Hoelscher M, Ibraim E, Kalsdorf B, Kaufmann SHE, Kontsevaya I, van Leth F, Mandalakas AM, Maurer FP, Müller M, Nitschkowski D, Olaru ID, Popa C, Rachow A, Rolling T, Rybniker J, Salzer HJF, Sanchez-Carballo P, Schuhmann M, Schaub D, Spinu V, Suárez I, Terhalle E, Unnewehr M, Weiner J, Goldmann T, Lange C
Prediction of anti-tuberculosis treatment duration based on a 22-gene transcriptomic model. Eur Respir J. 2021 09; 58(3).
Prediction of anti-tuberculosis treatment duration based on a 22-gene transcriptomic model.
Lange C, Aaby P, Behr MA, Donald PR, Kaufmann SHE, Netea MG, Mandalakas AM
100 years of Mycobacterium bovis bacille Calmette-Guérin. Lancet Infect Dis. 2022 01; 22(1):e2-e12.
100 years of Mycobacterium bovis bacille Calmette-Guérin.
War in Ukraine: an immense threat to the fight against tuberculosis. Eur Respir J. 2022 04; 59(4).
War in Ukraine: an immense threat to the fight against tuberculosis.
Bergeron A, Mikulska M, De Greef J, Bondeelle L, Franquet T, Herrmann JL, Lange C, Spriet I, Akova M, Donnelly JP, Maertens J, Maschmeyer G, Rovira M, Goletti D, de la Camara R
Mycobacterial infections in adults with haematological malignancies and haematopoietic stem cell transplants: guidelines from the 8th European Conference on Infections in Leukaemia. Lancet Infect Dis. 2022 12; 22(12):e359-e369.
Mycobacterial infections in adults with haematological malignancies and haematopoietic stem cell transplants: guidelines from the 8th European Conference on Infections in Leukaemia.
A revolution in the management of multidrug-resistant tuberculosis. Lancet. 2022 11 26; 400(10366):1823-1825.
A revolution in the management of multidrug-resistant tuberculosis.
Tunesi S, Dû DL, Gualano G, Millet JP, Skrahin A, Bothamley G, Casas X, Goletti D, Lange C, Musso M, Palmieri F, Pourcher V, Rioux C, Skrahina A, Veziris N, Viatushka D, Jachym-Fréchet M, Guglielmetti L
Co-administration of treatment for rifampicin-resistant TB and chronic HCV infection: A TBnet and ESGMYC study. J Infect. 2022 06; 84(6):834-872.
Co-administration of treatment for rifampicin-resistant TB and chronic HCV infection: A TBnet and ESGMYC study.
Sibandze DB, Kay A, Dreyer V, Sikhondze W, Dlamini Q, DiNardo A, Mtetwa G, Lukhele B, Vambe D, Lange C, Dlamini MG, Ness T, Mejia R, Kalsdorf B, Heyckendorf J, Kuhns M, Maurer FP, Dlamini S, Maphalala G, Niemann S, Mandalakas A
Correction: Rapid molecular diagnostics of tuberculosis resistance by targeted stool sequencing. Genome Med. 2022 Sep 20; 14(1):107.
Correction: Rapid molecular diagnostics of tuberculosis resistance by targeted stool sequencing.
DiNardo AR, Nishiguchi T, Grimm SL, Schlesinger LS, Graviss EA, Cirillo JD, Coarfa C, Mandalakas AM, Heyckendorf J, Kaufmann SHE, Lange C, Netea MG, Van Crevel R
Tuberculosis endotypes to guide stratified host-directed therapy. Med. 2021 03 12; 2(3):217-232.
Tuberculosis endotypes to guide stratified host-directed therapy.
Donald P, Kaufmann S, Thee S, Mandalakas AM, Lange C
Pathogenesis of tuberculosis: the 1930 Lübeck disaster revisited. Eur Respir Rev. 2022 Jun 30; 31(164).
Pathogenesis of tuberculosis: the 1930 Lübeck disaster revisited.
Vasiliu A, Saktiawati AMI, Duarte R, Lange C, Cirillo DM
Implementing molecular tuberculosis diagnostic methods in limited-resource and high-burden countries. Breathe (Sheff). 2022 Dec; 18(4):220226.
Implementing molecular tuberculosis diagnostic methods in limited-resource and high-burden countries.
Emerging bedaquiline-resistant tuberculosis. Lancet Microbe. 2023 12; 4(12):e964-e965.
Emerging bedaquiline-resistant tuberculosis.
Köhler N, Vasiliu A, Mandalakas AM, Martinez L, Lange C
Tuberculosis screening in migrants to the EU/EEA and UK. Eur Respir J. 2023 11; 62(5).
Tuberculosis screening in migrants to the EU/EEA and UK.
Shaw ES, Stoker NG, Potter JL, Claassen H, Leslie A, Tweed CD, Chiang CY, Conradie F, Esmail H, Lange C, Pinto L, Rucsineanu O, Sloan DJ, Theron G, Tisile P, Voo TC, Warren RM, Lebina L, Lipman M
Bedaquiline: what might the future hold? Lancet Microbe. 2024 12; 5(12):100909.
Bedaquiline: what might the future hold?
Donald PR, Kaufmann SHE, Schaub D, Thee S, Lange C
Carl Flügge, one of the last holistic hygienists and discoverer of droplet transmission of infectious diseases. Med Microbiol Immunol. 2024 Aug 02; 213(1):17.
Carl Flügge, one of the last holistic hygienists and discoverer of droplet transmission of infectious diseases.
Günther G, Guglielmetti L, Leu C, Lange C, van Leth F
Availability and costs of medicines for the treatment of tuberculosis in Europe. Clin Microbiol Infect. 2023 Jan; 29(1):77-84.
Availability and costs of medicines for the treatment of tuberculosis in Europe.
Nieuwenhuizen NE, Nouailles G, Sutherland JS, Zyla J, Pasternack AH, Heyckendorf J, Frye BC, Höhne K, Zedler U, Bandermann S, Abu Abed U, Brinkmann V, Gutbier B, Witzenrath M, Suttorp N, Zissel G, Lange C, Ritvos O, Kaufmann SHE
Activin A levels are raised during human tuberculosis and blockade of the activin signaling axis influences murine responses to M. tuberculosis infection. mBio. 2024 Mar 13; 15(3):e0340823.
Activin A levels are raised during human tuberculosis and blockade of the activin signaling axis influences murine responses to M. tuberculosis infection.
Motta I, Boeree M, Chesov D, Dheda K, Günther G, Horsburgh CR, Kherabi Y, Lange C, Lienhardt C, McIlleron HM, Paton NI, Stagg HR, Thwaites G, Udwadia Z, Van Crevel R, Velásquez GE, Wilkinson RJ, Guglielmetti L
Recent advances in the treatment of tuberculosis. Clin Microbiol Infect. 2024 Sep; 30(9):1107-1114.
Recent advances in the treatment of tuberculosis.
Diacon AH, Barry CE, Carlton A, Chen RY, Davies M, de Jager V, Fletcher K, Koh GCKW, Kontsevaya I, Heyckendorf J, Lange C, Reimann M, Penman SL, Scott R, Maher-Edwards G, Tiberi S, Vlasakakis G, Upton CM, Aguirre DB
A first-in-class leucyl-tRNA synthetase inhibitor, ganfeborole, for rifampicin-susceptible tuberculosis: a phase 2a open-label, randomized trial. Nat Med. 2024 03; 30(3):896-904.
A first-in-class leucyl-tRNA synthetase inhibitor, ganfeborole, for rifampicin-susceptible tuberculosis: a phase 2a open-label, randomized trial.
Günther G, Guglielmetti L, Kherabi Y, Duarte R, Lange C
Availability of drugs and resistance testing for bedaquiline, pretomanid, linezolid, and moxifloxacin (BPaL(M)) regimen for rifampicin-resistant tuberculosis in Europe. Clin Microbiol Infect. 2024 Sep; 30(9):1197.e1-1197.e4.
Availability of drugs and resistance testing for bedaquiline, pretomanid, linezolid, and moxifloxacin (BPaL(M)) regimen for rifampicin-resistant tuberculosis in Europe.
Kay A, Vasiliu A, Carratala-Castro L, Mtafya B, Mendez Reyes JE, Maphalala N, Munguambe S, Mulengwa D, Ness T, Saavedra B, Bacha J, Maphalala G, Mejia R, Mtetwa G, Acacio S, Manjate P, Mambuque E, Shiba N, Kota N, Ziyane M, Ntinginya NE, Lange C, Kirchner HL, DiNardo AR, Garcia-Basteiro AL, Mandalakas AM
Performance of a stool-based quantitative PCR assay for the diagnosis of tuberculosis in adolescents and adults: a multinational, prospective diagnostic accuracy study. Lancet Microbe. 2024 05; 5(5):e433-e441.
Performance of a stool-based quantitative PCR assay for the diagnosis of tuberculosis in adolescents and adults: a multinational, prospective diagnostic accuracy study.
Pedersen OS, Holmgaard FB, Mikkelsen MKD, Lange C, Sotgiu G, Lillebaek T, Andersen AB, Wejse CM, Dahl VN
Global treatment outcomes of extensively drug-resistant tuberculosis in adults: A systematic review and meta-analysis. J Infect. 2023 09; 87(3):177-189.
Global treatment outcomes of extensively drug-resistant tuberculosis in adults: A systematic review and meta-analysis.
Neuböck MJ, Günther G, Barac A, Davidsen JR, Laursen CB, Agarwal R, Sehgal IS, Lange C, Salzer HJF
Seminars in respiratory and critical care medicine
Chronic Pulmonary Aspergillosis as a Considerable Complication in Post-Tuberculosis Lung Disease. Semin Respir Crit Care Med. 2024 02; 45(1):102-113.
Chronic Pulmonary Aspergillosis as a Considerable Complication in Post-Tuberculosis Lung Disease.
Wetzstein N, Dahl VN, Lillebaek T, Lange C
Clinical spectrum and relevance of Mycobacterium malmoense: Systematic review and meta-analysis of 859 patients. J Infect. 2024 Aug; 89(2):106203.
Clinical spectrum and relevance of Mycobacterium malmoense: Systematic review and meta-analysis of 859 patients.
Brehm TT, Köhler N, Grobbel HP, Welling J, Mandalakas AM, Fava V, Schurr E, Lange C
High risk of drug-resistant tuberculosis in IGRA-negative contacts: should preventive treatment be considered? Infection. 2025 Aug; 53(4):1501-1506.
High risk of drug-resistant tuberculosis in IGRA-negative contacts: should preventive treatment be considered?
Jafari C, Olaru ID, Daduna F, Lange C, Kalsdorf B
Rapid Diagnosis of Recurrent Paucibacillary Tuberculosis. Pathog Immun. 2022; 7(2):189-202.
Rapid Diagnosis of Recurrent Paucibacillary Tuberculosis.
Meiwes L, Kontsevaya I, Chesov D, Kulcitkaia S, Dreyer V, Hillemann D, Dlamini Q, Williams C, Barer M, Brinkmann F, Krüger R, Thee S, Kay A, Mandalakas AM, Lange C
Whispers in the Wind: Face Mask Sampling for Mycobacterium tuberculosis Detection in Children With Pulmonary Tuberculosis. J Infect Dis. 2024 Dec 16; 230(6):1510-1517.
Whispers in the Wind: Face Mask Sampling for Mycobacterium tuberculosis Detection in Children With Pulmonary Tuberculosis.
Ivanova O, Hoffmann VS, Lange C, Hoelscher M, Rachow A
Post-tuberculosis lung impairment: systematic review and meta-analysis of spirometry data from 14?621 people. Eur Respir Rev. 2023 Jun 30; 32(168).
Post-tuberculosis lung impairment: systematic review and meta-analysis of spirometry data from 14?621 people.
Martinez L, Seddon JA, Horsburgh CR, Lange C, Mandalakas AM
Effectiveness of preventive treatment among different age groups and Mycobacterium tuberculosis infection status: a systematic review and individual-participant data meta-analysis of contact tracing studies. Lancet Respir Med. 2024 08; 12(8):633-641.
Effectiveness of preventive treatment among different age groups and Mycobacterium tuberculosis infection status: a systematic review and individual-participant data meta-analysis of contact tracing studies.
Ness T, Van LH, Petermane I, Duarte R, Lange C, Menzies D, Cirillo DM
Rolling out new anti-tuberculosis drugs without diagnostic capacity. Breathe (Sheff). 2023 Jun; 19(2):230084.
Rolling out new anti-tuberculosis drugs without diagnostic capacity.
Aspergillus-specific IgG antibodies for diagnosing chronic pulmonary aspergillosis compared with the reference standard-author's reply. Clin Microbiol Infect. 2024 May; 30(5):696-697.
Aspergillus-specific IgG antibodies for diagnosing chronic pulmonary aspergillosis compared with the reference standard-author's reply.
Chesov E, Chesov D, Reimann M, Dreyer V, Utpatel C, Gröschel MI, Ciobanu N, Crudu V, Lange C, Heyckendorf J, Merker M
Impact of Mycobacterium tuberculosis strain type on multidrug-resistant tuberculosis severity, Republic of Moldova. J Infect. 2023 12; 87(6):588-591.
Impact of Mycobacterium tuberculosis strain type on multidrug-resistant tuberculosis severity, Republic of Moldova.
Vasiliu A, Köhler N, Altpeter E, Ægisdóttir TR, Amerali M, de Oñate WA, Bakos Á, D'Amato S, Cirillo DM, van Crevel R, Davidaviciene E, Demuth I, Domínguez J, Duarte R, Günther G, Guthmann JP, Hatzianastasiou S, Holm LH, Herrador Z, Hribar U, Huberty C, Ibraim E, Jackson S, Jensenius M, Josefsdottir KS, Koch A, Korzeniewska-Kosela M, Kuksa L, Kunst H, Lienhardt C, Mahler B, Makek MJ, Muylle I, Normark J, Pace-Asciak A, Petrovic G, Pieridou D, Russo G, Rzhepishevska O, Salzer HJF, Marques MS, Schmid D, Solovic I, Sukholytka M, Svetina P, Tyufekchieva M, Vasankari T, Viiklepp P, Villand K, Wallenfels J, Wesolowski S, Mandalakas AM, Martinez L, Zenner D, Lange C
Tuberculosis incidence in foreign-born people residing in European countries in 2020. Euro Surveill. 2023 10; 28(42).
Tuberculosis incidence in foreign-born people residing in European countries in 2020.
Salzer HJF, Reimann M, Oertel C, Davidsen JR, Laursen CB, Van Braeckel E, Agarwal R, Avsar K, Munteanu O, Irfan M, Lange C
Aspergillus-specific IgG antibodies for diagnosing chronic pulmonary aspergillosis compared to the reference standard. Clin Microbiol Infect. 2023 Dec; 29(12):1605.e1-1605.e4.
Aspergillus-specific IgG antibodies for diagnosing chronic pulmonary aspergillosis compared to the reference standard.
Ramachandran R, Dumitrescu A, Baiceanu D, Popa C, Dragomir A, Mahler B, Hoelscher M, Lange C, Heyckendorf J, Rachow A, Ibraim E, Ivanova O
Journal of health, population, and nutrition
Impact of drug-resistant tuberculosis on socio-economic status, quality of life and psychological well-being of patients in Bucharest, Romania: a prospective cohort study. J Health Popul Nutr. 2024 12 22; 43(1):223.
Impact of drug-resistant tuberculosis on socio-economic status, quality of life and psychological well-being of patients in Bucharest, Romania: a prospective cohort study.
(Re-)introduction of TNF antagonists and JAK inhibitors in patients with previous tuberculosis: a systematic review. Clin Microbiol Infect. 2024 Aug; 30(8):989-998.
(Re-)introduction of TNF antagonists and JAK inhibitors in patients with previous tuberculosis: a systematic review.
Ness T, Maphalala N, Khumalo W, Sibandze D, Seeger A, Madison M, Vasiliu A, Mulengwa D, Gascua C, Ziyane M, Dlamini S, Maphalala G, Bortz E, Kay A, Lange C, Dreyer V, Niemann T, Niemann S, DiNardo A, Mandalakas A
Rapid Diagnostic Sequencing of Stool DNA Using Targeted Nanopore Sequencing in Patients With a Pulmonary Tuberculosis Diagnosis. Open Forum Infect Dis. 2025 Apr; 12(4):ofaf121.
Rapid Diagnostic Sequencing of Stool DNA Using Targeted Nanopore Sequencing in Patients With a Pulmonary Tuberculosis Diagnosis.
Gillespie SH, DiNardo AR, Georghiou SB, Sabiiti W, Kohli M, Panzner U, Kontsevaya I, Hittel N, Stuyver LJ, Tan JB, van Crevel R, Lange C, Thuong TNT, Heyckendorf J, Ruhwald M, Heinrich N
Developing biomarker assays to accelerate tuberculosis drug development: defining target product profiles. Lancet Microbe. 2024 09; 5(9):100869.
Developing biomarker assays to accelerate tuberculosis drug development: defining target product profiles.
Neumann M, Reimann M, Chesov D, Popa C, Dragomir A, Popescu O, Munteanu R, Hölscher A, Honeyborne I, Heyckendorf J, Lange C, Hölscher C, Kalsdorf B
The molecular bacterial load assay predicts treatment responses in patients with pre-XDR/XDR-tuberculosis more accurately than GeneXpert Ultra MTB/Rif. J Infect. 2025 Feb; 90(2):106399.
The molecular bacterial load assay predicts treatment responses in patients with pre-XDR/XDR-tuberculosis more accurately than GeneXpert Ultra MTB/Rif.
Dudnyk A, Lutchmun W, Duarte R, Lange C, Svensson EM
The importance of getting the dose right in the treatment of tuberculosis. Breathe (Sheff). 2025 Jan; 21(1):240177.
The importance of getting the dose right in the treatment of tuberculosis.
Lange C, Bothamley G, Günther G, Guglielmetti L, Kontsevaya I, Kuksa L, Lange B, Lorent N, Saluzzo F, Sester M, Tebruegge M, Tunesi S, Tweed C
A Year in Review on Tuberculosis and Non-tuberculous Mycobacteria Disease: A 2025 Update for Clinicians and Scientists. Pathog Immun. 2025; 10(2):1-45.
A Year in Review on Tuberculosis and Non-tuberculous Mycobacteria Disease: A 2025 Update for Clinicians and Scientists.
Lee S, Hecker J, Vardarajan BN, Kelly RS, Prince N, Mullin K, Lutz SM, Hahn G, Lasky-Su J, Mayeux RP, Tanzi RE, Lange C, Prokopenko D
Uncovering Ethnicity-Specific Recessive Loci for Alzheimer's Disease in 89 Dominican Families Using Family-Based WGS Analysis. Genet Epidemiol. 2025 Jul; 49(5):e70014.
Uncovering Ethnicity-Specific Recessive Loci for Alzheimer's Disease in 89 Dominican Families Using Family-Based WGS Analysis.
Cirillo D, Anthony R, Gagneux S, Horsburgh CR, Hasan R, Darboe S, Laniado-Laborin R, Probandari A, Tukvadze N, Arcêncio RA, Bimba JS, Brighenti S, Chesov D, Chiang CY, Kalmambetova G, Knight G, Konstantynovska O, Kruse A, Lange C, Mayanja-Kizza H, McBryde E, Min J, Sanchez-Montalva A, Sulis G, Tsogt B, Van Der Walt M, Yeboah-Manu D, Hauser J
A successful UN High-Level Meeting on antimicrobial resistance must build on the 2023 UN High-Level Meeting on tuberculosis. Lancet Glob Health. 2024 08; 12(8):e1225-e1226.
A successful UN High-Level Meeting on antimicrobial resistance must build on the 2023 UN High-Level Meeting on tuberculosis.
DiNardo AR, Sabiiti W, Gillespie SH, Georghiou SB, Heinrich N, Hittel N, Taghlabi S, Carrero Longlax D, Kohli M, Panzner U, Musia C, Lange C, Vasiliu A, Arts RJW, Mandalakas AM, Ruhwald M, Stuyver LJ, van Crevel R
Inclusion of patient-centered, non-microbiological endpoints and biomarkers in tuberculosis drug trials. Front Antibiot. 2025; 4:1570989.
Inclusion of patient-centered, non-microbiological endpoints and biomarkers in tuberculosis drug trials.
Peterka M, Krieger D, Khatamzas E, Denkinger CM, Köhler N, Lange C, Macholz M, Lübbert C, Daller S, Knappik M, Kuhns M, Häcker B, Polsfuß S, Bauer T, Otto-Knapp R
Safety of high dose bedaquiline treatment in patients with extensively drug-resistant tuberculosis. Eur Respir J. 2026 Jan; 67(1).
Safety of high dose bedaquiline treatment in patients with extensively drug-resistant tuberculosis.
Chang JB, Barnhill CP, Apostolov AM, Soliai MM, Hecker J, Nierenberg JL, Stapleton Smith LM, Mathew AS, Zeng X, Diao J, Fernando CD, Chen Q, Dulken BW, Petukhov A, Altman R, Josephs TM, Lasky-Su JA, Gorvin CM, Roberts MS, Adler SH, Fox JC, Lange C, Ji SG
A calcium-sensing receptor allelic series and underdiagnosis of genetically driven hypocalcemia. Am J Hum Genet. 2025 Aug 07; 112(8):1818-1832.
A calcium-sensing receptor allelic series and underdiagnosis of genetically driven hypocalcemia.
Corrigendum to "Candidate anti-tuberculosis medicines and regimens under clinical evaluation" [Clin Microbiol Infect 30(9) (2024) 1131-1138]. Clin Microbiol Infect. 2026 Jan; 32(1):199.
Corrigendum to "Candidate anti-tuberculosis medicines and regimens under clinical evaluation" [Clin Microbiol Infect 30(9) (2024) 1131-1138].
Kherabi Y, Skouvig Pedersen O, Lange C, Bénézit F, Chesov D, Codecasa LR, Dudnyk A, Kiria N, Konstantynovska O, Marigot-Outtandy D, Panciu TC, Poignon C, Sasi S, Schaub D, Solodovnikova V, Vasiliauskaitè L, Yeghiazaryan L, Günther G, Guglielmetti L
Treatment outcomes of extensively drug-resistant tuberculosis in Europe: a retrospective cohort study. Lancet Reg Health Eur. 2025 Sep; 56:101380.
Treatment outcomes of extensively drug-resistant tuberculosis in Europe: a retrospective cohort study.
Pinheiro M, Aguiar A, Moreira DN, Akkerman OW, Al-Suwaidi Z, Alffenaar JC, Arandjelovic I, Brito U, de Colombani P, Curcic R, Garcia-Basteiro AL, Goletti D, Günther G, Ibraim E, Kapata N, Lange C, Lipman M, Jankovic Makek M, Marais BJ, Mariandyshev A, Magis-Escurra C, Migliori GB, Sánchez Montalvá A, Nanovic Z, Palmero DJ, Priwitzer M, Raviglione MCB, Silva DR, Salzer HJF, Schwarzbach C, Spruijt I, Winthrop KL, Udwadia Z, Vasankari T, Vilaplana C, Duarte R
A multinational Delphi consensus on tuberculosis screening of migrants in Europe. ERJ Open Res. 2025 Nov; 11(6).
A multinational Delphi consensus on tuberculosis screening of migrants in Europe.
Epple HJ, Domaszewska T, Brünneck AV, Furth C, Dommerich S, Lange C, Schöning DV, Maschmeyer G, Bös L, Schwartz S, Schneider T, Mathas S
At the crossroads of infection and malignancy: the challenge of tuberculosis in migrating populations - Case Report and Epidemiologic Analysis. BMC Infect Dis. 2025 Dec 23; 26(1):145.
At the crossroads of infection and malignancy: the challenge of tuberculosis in migrating populations - Case Report and Epidemiologic Analysis.
Leo F, Polsfuss S, Przewosnik AS, Grohé C, Lange C
Mycobacterium florentinum pulmonary disease: a case report and review of the literature. BMC Infect Dis. 2025 Dec 17; 26(1):103.
Mycobacterium florentinum pulmonary disease: a case report and review of the literature.
Moreira-Sousa D, Martins B, Aguiar A, Pinheiro M, Akkerman O, Aksamit TR, Aliberti S, Andrejak C, Daley CL, van Ingen J, Lange C, Lipman M, Loebinger MR, Jankovic Makek M, Morimoto K, Thomson RM, Wagner D, Winthrop KL, Yim JJ, Duarte R
Consensus on the management of refractory nontuberculous mycobacterial pulmonary disease. Eur Respir J. 2026 Jan; 67(1).
Consensus on the management of refractory nontuberculous mycobacterial pulmonary disease.
Hecker J, Prokopenko D, Hahn G, Lee S, Lutz SM, Lange C
Analyzing associations and higher-order effects in multi-omics data with double machine learning. bioRxiv. 2025 Dec 08.
Analyzing associations and higher-order effects in multi-omics data with double machine learning.
Ma'aruf SY, Sharma A, Fox S, Duarte R, Lange C, Tiberi S
Management of adverse events in TB care and active TB drug safety monitoring. Breathe (Sheff). 2026 Jan; 22(1):250203.
Management of adverse events in TB care and active TB drug safety monitoring.
Ahmad R, Ramos JP, Duarte R, Lange C, Van Rest J
Enhancing tuberculosis care in lower and middle-income countries through digital adherence technologies. Breathe (Sheff). 2026 Jan; 22(1):250173.
Enhancing tuberculosis care in lower and middle-income countries through digital adherence technologies.
Tulu B, Brehm TT, van Crevel R, Dallenga T, DiNardo AR, Dheda K, Eggeling J, Enbiale W, Gröschel MI, Hao J, Kumar V, van Laarhoven A, Londt R, Prosser G, Randall P, Reiling N, Rybniker J, Schaible UE, Schurr E, Suarez I, Theobald SJ, Wilkinson RJ, Lange C
Host- and pathogen-related determinants of pulmonary versus extrapulmonary tuberculosis. Eur Respir Rev. 2026 01; 35(179).
Host- and pathogen-related determinants of pulmonary versus extrapulmonary tuberculosis.
Woelk D, Meiwes L, Ciobanu N, Crudu V, Comanac AM, Kulcitkaia S, Vasiliu A, Mandalakas AM, Lange C, Brehm TT, Chesov D
Noninvasive diagnosis of pulmonary tuberculosis using face mask sampling: a prospective study in adults. Clin Microbiol Infect. 2026 Apr; 32(4):644-649.
Noninvasive diagnosis of pulmonary tuberculosis using face mask sampling: a prospective study in adults.
Moreira-Sousa D, Martins B, Aguiar A, Pinheiro M, Akkerman OW, Aksamit TR, Aliberti S, Andrejak C, Daley CL, van Ingen J, Lange C, Lipman M, Loebinger MR, Jankovic Makek M, Morimoto K, Thomson R, Wagner D, Winthrop KL, Yim JJ, Duarte R
Management of nontuberculous mycobacterial Pulmonary disease refractory to guideline-based therapy: A systematic review. Pulmonology. 2026 Dec; 32(1):2632467.
Management of nontuberculous mycobacterial Pulmonary disease refractory to guideline-based therapy: A systematic review.
Al Chawa T, Ludwig KU, Fier H, Pötzsch B, Reich RH, Schmidt G, Braumann B, Daratsianos N, Böhmer AC, Schuencke H, Alblas M, Fricker N, Hoffmann P, Knapp M, Lange C, Nöthen MM, Mangold E
Nonsyndromic cleft lip with or without cleft palate: Increased burden of rare variants within Gremlin-1, a component of the bone morphogenetic protein 4 pathway. Birth Defects Res A Clin Mol Teratol. 2014 Jun; 100(6):493-8.
Nonsyndromic cleft lip with or without cleft palate: Increased burden of rare variants within Gremlin-1, a component of the bone morphogenetic protein 4 pathway.
Associate Professor of Population Medicine
An alternative hypothesis testing strategy for secondary phenotype data in case-control genetic association studies. Front Genet. 2014; 5:188.
An alternative hypothesis testing strategy for secondary phenotype data in case-control genetic association studies.
Hooli BV, Parrado AR, Mullin K, Yip WK, Liu T, Roehr JT, Qiao D, Jessen F, Peters O, Becker T, Ramirez A, Lange C, Bertram L, Tanzi RE
The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk. Neurology. 2014 Oct 07; 83(15):1353-8.
The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk.
Blumenthal A, Ehlers S, Lauber J, Buer J, Lange C, Goldmann T, Heine H, Brandt E, Reiling N
The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood. 2006 Aug 01; 108(3):965-73.
The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation.
Choi S, Lee S, Cichon S, Nöthen MM, Lange C, Park T, Won S
FARVAT: a family-based rare variant association test. Bioinformatics. 2014 Nov 15; 30(22):3197-205.
FARVAT: a family-based rare variant association test.
Gutsfeld C, Olaru ID, Vollrath O, Lange C
Attitudes about tuberculosis prevention in the elimination phase: a survey among physicians in Germany. PLoS One. 2014; 9(11):e112681.
Attitudes about tuberculosis prevention in the elimination phase: a survey among physicians in Germany.
Yip WK, Fier H, DeMeo DL, Aryee M, Laird N, Lange C
A novel method for detecting association between DNA methylation and diseases using spatial information. Genet Epidemiol. 2014 Dec; 38(8):714-21.
A novel method for detecting association between DNA methylation and diseases using spatial information.
A general framework for robust and efficient association analysis in family-based designs: quantitative and dichotomous phenotypes. Stat Med. 2013 Nov 10; 32(25):4482-98.
A general framework for robust and efficient association analysis in family-based designs: quantitative and dichotomous phenotypes.
Hooli BV, Lill CM, Mullin K, Qiao D, Lange C, Bertram L, Tanzi RE
PLD3 gene variants and Alzheimer's disease. Nature. 2015 Apr 02; 520(7545):E7-8.
PLD3 gene variants and Alzheimer's disease.
Castaldi PJ, Cho MH, Zhou X, Qiu W, Mcgeachie M, Celli B, Bakke P, Gulsvik A, Lomas DA, Crapo JD, Beaty TH, Rennard S, Harshfield B, Lange C, Singh D, Tal-Singer R, Riley JH, Quackenbush J, Raby BA, Carey VJ, Silverman EK, Hersh CP
Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci. Hum Mol Genet. 2015 Feb 15; 24(4):1200-10.
Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci.
Mattheisen M, Samuels JF, Wang Y, Greenberg BD, Fyer AJ, McCracken JT, Geller DA, Murphy DL, Knowles JA, Grados MA, Riddle MA, Rasmussen SA, McLaughlin NC, Nurmi EL, Askland KD, Qin HD, Cullen BA, Piacentini J, Pauls DL, Bienvenu OJ, Stewart SE, Liang KY, Goes FS, Maher B, Pulver AE, Shugart YY, Valle D, Lange C, Nestadt G
Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. Mol Psychiatry. 2015 Mar; 20(3):337-44.
Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS.
Kalsdorf B, Skolimowska KH, Scriba TJ, Dawson R, Dheda K, Wood K, Hofmeister J, Hanekom WA, Lange C, Wilkinson RJ
Relationship between chemokine receptor expression, chemokine levels and HIV-1 replication in the lungs of persons exposed to Mycobacterium tuberculosis. Eur J Immunol. 2013 Feb; 43(2):540-9.
Relationship between chemokine receptor expression, chemokine levels and HIV-1 replication in the lungs of persons exposed to Mycobacterium tuberculosis.
McDonald ML, Mattheisen M, Cho MH, Liu YY, Harshfield B, Hersh CP, Bakke P, Gulsvik A, Lange C, Beaty TH, Silverman EK
Beyond GWAS in COPD: probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks. Hum Hered. 2014; 78(3-4):131-9.
Beyond GWAS in COPD: probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks.
Basmanav FB, Forstner AJ, Fier H, Herms S, Meier S, Degenhardt F, Hoffmann P, Barth S, Fricker N, Strohmaier J, Witt SH, Ludwig M, Schmael C, Moebus S, Maier W, Mössner R, Rujescu D, Rietschel M, Lange C, Nöthen MM, Cichon S
Investigation of the role of TCF4 rare sequence variants in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2015 Jul; 168B(5):354-62.
Investigation of the role of TCF4 rare sequence variants in schizophrenia.
Prokopenko D, Hecker J, Silverman E, Nöthen MM, Schmid M, Lange C, Loehlein Fier H
Using Network Methodology to Infer Population Substructure. PLoS One. 2015; 10(6):e0130708.
Using Network Methodology to Infer Population Substructure.
Zhou JJ, Cho MH, Lange C, Lutz S, Silverman EK, Laird NM
Integrating Multiple Correlated Phenotypes for Genetic Association Analysis by Maximizing Heritability. Hum Hered. 2015; 79(2):93-104.
Integrating Multiple Correlated Phenotypes for Genetic Association Analysis by Maximizing Heritability.
Günther G, Gomez GB, Lange C, Rupert S, van Leth F
Availability, price and affordability of anti-tuberculosis drugs in Europe: a TBNET survey. Eur Respir J. 2015 Apr; 45(4):1081-8.
Availability, price and affordability of anti-tuberculosis drugs in Europe: a TBNET survey.
Essone PN, Kalsdorf B, Chegou NN, Loxton AG, Kriel M, Preyer R, Ernst M, Walzl G, Lange C
Bifunctional T-cell-derived cytokines for the diagnosis of tuberculosis and treatment monitoring. Respiration. 2014; 88(3):251-61.
Bifunctional T-cell-derived cytokines for the diagnosis of tuberculosis and treatment monitoring.
Park S, Lee S, Lee Y, Herold C, Hooli B, Mullin K, Park T, Park C, Bertram L, Lange C, Tanzi R, Won S
Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families. BMC Med Genet. 2015 Aug 19; 16:62.
Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families.
Lutz SM, Cho MH, Young K, Hersh CP, Castaldi PJ, McDonald ML, Regan E, Mattheisen M, DeMeo DL, Parker M, Foreman M, Make BJ, Jensen RL, Casaburi R, Lomas DA, Bhatt SP, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Laird NM, Lange C, Hokanson JE, Silverman EK
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genet. 2015 Dec 03; 16:138.
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
Hecker J, Prokopenko D, Lange C, Fier HL
On the Recombination Rate Estimation in the Presence of Population Substructure. PLoS One. 2015; 10(12):e0145152.
On the Recombination Rate Estimation in the Presence of Population Substructure.
Journal of acquired immune deficiency syndromes (1999)
Viral Load and Risk of Tuberculosis in HIV Infection. J Acquir Immune Defic Syndr. 2016 Feb 01; 71(2):e51-3.
Viral Load and Risk of Tuberculosis in HIV Infection.
Zellweger JP, Sotgiu G, Block M, Dore S, Altet N, Blunschi R, Bogyi M, Bothamley G, Bothe C, Codecasa L, Costa P, Dominguez J, Duarte R, Fløe A, Fresard I, García-García JM, Goletti D, Halm P, Hellwig D, Henninger E, Heykes-Uden H, Horn L, Kruczak K, Latorre I, Pache G, Rath H, Ringshausen FC, Ruiz AS, Solovic I, Souza-Galvão ML, Widmer U, Witte P, Lange C
Risk Assessment of Tuberculosis in Contacts by IFN-? Release Assays. A Tuberculosis Network European Trials Group Study. Am J Respir Crit Care Med. 2015 May 15; 191(10):1176-84.
Risk Assessment of Tuberculosis in Contacts by IFN-? Release Assays. A Tuberculosis Network European Trials Group Study.
Blauenfeldt T, Heyckendorf J, Graff Jensen S, Lange C, Drabe C, Hermansen TS, de Thurah L, Lillebaek T, Eugen-Olsen J, Seersholm N, Hoff S, Bonde J, Ruhwald M
Development of a one-step probe based molecular assay for rapid immunodiagnosis of infection with M. tuberculosis using dried blood spots. PLoS One. 2014; 9(9):e105628.
Development of a one-step probe based molecular assay for rapid immunodiagnosis of infection with M. tuberculosis using dried blood spots.
Sester M, van Leth F, Bruchfeld J, Bumbacea D, Cirillo DM, Dilektasli AG, Domínguez J, Duarte R, Ernst M, Eyuboglu FO, Gerogianni I, Girardi E, Goletti D, Janssens JP, Julander I, Lange B, Latorre I, Losi M, Markova R, Matteelli A, Milburn H, Ravn P, Scholman T, Soccal PM, Straub M, Wagner D, Wolf T, Yalcin A, Lange C
Risk assessment of tuberculosis in immunocompromised patients. A TBNET study. Am J Respir Crit Care Med. 2014 Nov 15; 190(10):1168-76.
Risk assessment of tuberculosis in immunocompromised patients. A TBNET study.
Prokopenko D, Hecker J, Silverman EK, Pagano M, Nöthen MM, Dina C, Lange C, Fier HL
Utilizing the Jaccard index to reveal population stratification in sequencing data: a simulation study and an application to the 1000 Genomes Project. Bioinformatics. 2016 05 01; 32(9):1366-72.
Utilizing the Jaccard index to reveal population stratification in sequencing data: a simulation study and an application to the 1000 Genomes Project.
Mitnick CD, Rodriguez CA, Hatton ML, Brigden G, Cobelens F, Grobusch MP, Horsburgh R, Lange C, Lienhardt C, Oren E, Podewils LJ, Seaworth B, van den Hof S, Daley CL, Gebhard AC, Wares F
Programmatic Management of Drug-Resistant Tuberculosis: An Updated Research Agenda. PLoS One. 2016; 11(5):e0155968.
Programmatic Management of Drug-Resistant Tuberculosis: An Updated Research Agenda.
Qiao D, Lange C, Beaty TH, Crapo JD, Barnes KC, Bamshad M, Hersh CP, Morrow J, Pinto-Plata VM, Marchetti N, Bueno R, Celli BR, Criner GJ, Silverman EK, Cho MH
Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 06 15; 193(12):1353-63.
Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease.
Busch M, Herzmann C, Kallert S, Zimmermann A, Höfer C, Mayer D, Zenk SF, Muche R, Lange C, Bloom BR, Modlin RL, Stenger S
Lipoarabinomannan-Responsive Polycytotoxic T Cells Are Associated with Protection in Human Tuberculosis. Am J Respir Crit Care Med. 2016 08 01; 194(3):345-55.
Lipoarabinomannan-Responsive Polycytotoxic T Cells Are Associated with Protection in Human Tuberculosis.
Olaru ID, Lange C, Indra A, Meidlinger L, Huhulescu S, Rumetshofer R
High Rates of Treatment Success in Pulmonary Multidrug-Resistant Tuberculosis by Individually Tailored Treatment Regimens. Ann Am Thorac Soc. 2016 08; 13(8):1271-8.
High Rates of Treatment Success in Pulmonary Multidrug-Resistant Tuberculosis by Individually Tailored Treatment Regimens.
Common Genetic Determinants of Asthma and COPD-PROGRAM PROJECT
Novel Statistical Approaches to Mental Health Phenotype Analysis in GWA Studies
A New Approach to Mental Health Phenotypes in Family Genomewide Association
Preparing Association Analysis Software Tools for Next Generation Sequencing Data
Won S, Bertram L, Becker D, Tanzi RE, Lange C
Maximizing the Power of Genome-Wide Association Studies: A Novel Class of Powerful Family-Based Association Tests. Stat Biosci. 2009 Nov; 1(2):125-143.
Maximizing the Power of Genome-Wide Association Studies: A Novel Class of Powerful Family-Based Association Tests.
McDonald MN, Won S, Mattheisen M, Castaldi PJ, Cho MH, Rutten E, Hardin M, Yip WK, Rennard SI, Lomas DA, Wouters EFM, Agusti A, Casaburi R, Lange CP, O'Connor G, Hersh CP, Silverman EK
Journal of cachexia, sarcopenia and muscle
Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. J Cachexia Sarcopenia Muscle. 2017 Jun; 8(3):428-436.
Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1.
Lutz SM, Fingerlin TE, Hokanson JE, Lange C
A general approach to testing for pleiotropy with rare and common variants. Genet Epidemiol. 2017 Feb; 41(2):163-170.
A general approach to testing for pleiotropy with rare and common variants.
DeMeo DL, Lange C, Silverman EK, Senter JM, Drazen JM, Barth MJ, Laird N, Weiss ST
Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program. Genet Epidemiol. 2002 Nov; 23(4):335-48.
Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program.
Raby BA, Silverman EK, Lazarus R, Lange C, Kwiatkowski DJ, Weiss ST
Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes. Hum Mol Genet. 2003 Aug 15; 12(16):1973-9.
Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes.
Lange C, Lyon H, DeMeo D, Raby B, Silverman EK, Weiss ST
A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies. Hum Hered. 2003; 56(1-3):10-7.
A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies.
Qiao D, Lange C, Laird NM, Won S, Hersh CP, Morrow J, Hobbs BD, Lutz SM, Ruczinski I, Beaty TH, Silverman EK, Cho MH
Gene-based segregation method for identifying rare variants in family-based sequencing studies. Genet Epidemiol. 2017 05; 41(4):309-319.
Gene-based segregation method for identifying rare variants in family-based sequencing studies.
Lange C, Mandalakas AM, Kalsdorf B, Denkinger CM, Sester M
Clinical Application of Interferon-? Release Assays for the Prevention of Tuberculosis in Countries with Low Incidence. Pathog Immun. 2016; 1(2):308-329.
Clinical Application of Interferon-? Release Assays for the Prevention of Tuberculosis in Countries with Low Incidence.
New powerful approaches for family-based association tests with longitudinal measurements. Ann Hum Genet. 2009 Jan; 73(1):74-83.
New powerful approaches for family-based association tests with longitudinal measurements.
Hoffmann TJ, Lange C, Vansteelandt S, Raby BA, DeMeo DL, Silverman EK, Weiss ST, Laird NM
Parsing the effects of individual SNPs in candidate genes with family data. Hum Hered. 2010; 69(2):91-103.
Parsing the effects of individual SNPs in candidate genes with family data.
Identification of genetic outliers due to sub-structure and cryptic relationships. Bioinformatics. 2017 Jul 01; 33(13):1972-1979.
Identification of genetic outliers due to sub-structure and cryptic relationships.
Loehlein Fier H, Prokopenko D, Hecker J, Cho MH, Silverman EK, Weiss ST, Tanzi RE, Lange C
On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows. Genet Epidemiol. 2017 05; 41(4):332-340.
On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows.
Dheda K, Gumbo T, Maartens G, Dooley KE, McNerney R, Murray M, Furin J, Nardell EA, London L, Lessem E, Theron G, van Helden P, Niemann S, Merker M, Dowdy D, Van Rie A, Siu GK, Pasipanodya JG, Rodrigues C, Clark TG, Sirgel FA, Esmail A, Lin HH, Atre SR, Schaaf HS, Chang KC, Lange C, Nahid P, Udwadia ZF, Horsburgh CR, Churchyard GJ, Menzies D, Hesseling AC, Nuermberger E, McIlleron H, Fennelly KP, Goemaere E, Jaramillo E, Low M, Jara CM, Padayatchi N, Warren RM
The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis. Lancet Respir Med. 2017 Mar 15.
The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis.
Hecker J, Maaser A, Prokopenko D, Fier HL, Lange C
Twin research and human genetics : the official journal of the International Society for Twin Studies
Reporting Correct p Values in VEGAS Analyses. Twin Res Hum Genet. 2017 06; 20(3):257-259.
Reporting Correct p Values in VEGAS Analyses.
Lange C, DeMeo D, Silverman EK, Weiss ST, Laird NM
PBAT: tools for family-based association studies. Am J Hum Genet. 2004 Feb; 74(2):367-9.
PBAT: tools for family-based association studies.
Ince MN, Harnisch B, Xu Z, Lee SK, Lange C, Moretta L, Lederman M, Lieberman J
Increased expression of the natural killer cell inhibitory receptor CD85j/ILT2 on antigen-specific effector CD8 T cells and its impact on CD8 T-cell function. Immunology. 2004 Aug; 112(4):531-42.
Increased expression of the natural killer cell inhibitory receptor CD85j/ILT2 on antigen-specific effector CD8 T cells and its impact on CD8 T-cell function.
Bertram L, Hsiao M, Lange C, Blacker D, Tanzi RE
Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples. Am J Hum Genet. 2006 Jul; 79(1):180-3; author reply 183-4.
Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples.
Power and design considerations for a general class of family-based association tests: quantitative traits. Am J Hum Genet. 2002 Dec; 71(6):1330-41.
Power and design considerations for a general class of family-based association tests: quantitative traits.
Hooli BV, Mohapatra G, Mattheisen M, Parrado AR, Roehr JT, Shen Y, Gusella JF, Moir R, Saunders AJ, Lange C, Tanzi RE, Bertram L
Role of common and rare APP DNA sequence variants in Alzheimer disease. Neurology. 2012 Apr 17; 78(16):1250-7.
Role of common and rare APP DNA sequence variants in Alzheimer disease.
Celedón JC, Lange C, Raby BA, Litonjua AA, Palmer LJ, DeMeo DL, Reilly JJ, Kwiatkowski DJ, Chapman HA, Laird N, Sylvia JS, Hernandez M, Speizer FE, Weiss ST, Silverman EK
The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet. 2004 Aug 01; 13(15):1649-56.
The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD).
Vansteelandt S, Demeo DL, Lasky-Su J, Smoller JW, Murphy AJ, McQueen M, Schneiter K, Celedon JC, Weiss ST, Silverman EK, Lange C
Testing and estimating gene-environment interactions in family-based association studies. Biometrics. 2008 Jun; 64(2):458-67.
Testing and estimating gene-environment interactions in family-based association studies.
Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet. 2003 Oct; 73(4):801-11.
Using the noninformative families in family-based association tests: a powerful new testing strategy.
Neale BM, Lasky-Su J, Anney R, Franke B, Zhou K, Maller JB, Vasquez AA, Asherson P, Chen W, Banaschewski T, Buitelaar J, Ebstein R, Gill M, Miranda A, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Sonuga-Barke E, Mulas F, Taylor E, Laird N, Lange C, Daly M, Faraone SV
Genome-wide association scan of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 05; 147B(8):1337-44.
Genome-wide association scan of attention deficit hyperactivity disorder.
Weiss ST, Litonjua AA, Lange C, Lazarus R, Liggett SB, Bleecker ER, Tantisira KG
Overview of the pharmacogenetics of asthma treatment. Pharmacogenomics J. 2006 Sep-Oct; 6(5):311-26.
Overview of the pharmacogenetics of asthma treatment.
On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power, and optimality considerations. Genet Epidemiol. 2002 Aug; 23(2):165-80.
On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power, and optimality considerations.
Raby BA, Van Steen K, Celedón JC, Litonjua AA, Lange C, Weiss ST
Paternal history of asthma and airway responsiveness in children with asthma. Am J Respir Crit Care Med. 2005 Sep 01; 172(5):552-8.
Paternal history of asthma and airway responsiveness in children with asthma.
Van Steen K, McQueen MB, Herbert A, Raby B, Lyon H, Demeo DL, Murphy A, Su J, Datta S, Rosenow C, Christman M, Silverman EK, Laird NM, Weiss ST, Lange C
Genomic screening and replication using the same data set in family-based association testing. Nat Genet. 2005 Jul; 37(7):683-91.
Genomic screening and replication using the same data set in family-based association testing.
Lipman PJ, Yip WK, AlChawa T, Ludwig KU, Mangold E, Lange C
On the analysis of sequence data: testing for disease susceptibility loci using patterns of linkage disequilibrium. Genet Epidemiol. 2011 Dec; 35(8):880-6.
On the analysis of sequence data: testing for disease susceptibility loci using patterns of linkage disequilibrium.
DeMeo D, Mariani T, Lange C, Lake S, Litonjua A, Celedón J, Reilly J, Chapman HA, Sparrow D, Spira A, Beane J, Pinto-Plata V, Speizer FE, Shapiro S, Weiss ST, Silverman EK
Proceedings of the American Thoracic Society
The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Aug; 3(6):502.
The SERPINE2 gene is associated with chronic obstructive pulmonary disease.
Fardo D, Celedón JC, Raby BA, Weiss ST, Lange C
On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice. Genet Epidemiol. 2007 Jul; 31(5):376-82.
On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice.
Goletti D, Carrara S, Stefania C, Butera O, Amicosante M, Ernst M, Sauzullo I, Vullo V, Cirillo D, Borroni E, Markova R, Drenska R, Dominguez J, Latorre I, Angeletti C, Navarra A, Petrosillo N, Lauria FN, Ippolito G, Migliori GB, Lange C, Girardi E
Accuracy of immunodiagnostic tests for active tuberculosis using single and combined results: a multicenter TBNET-Study. PLoS One. 2008; 3(10):e3417.
Accuracy of immunodiagnostic tests for active tuberculosis using single and combined results: a multicenter TBNET-Study.
Hoffmann TJ, Lange C, Vansteelandt S, Laird NM
Gene-environment interaction tests for dichotomous traits in trios and sibships. Genet Epidemiol. 2009 Dec; 33(8):691-9.
Gene-environment interaction tests for dichotomous traits in trios and sibships.
Raby BA, Klimecki WT, Laprise C, Renaud Y, Faith J, Lemire M, Greenwood C, Weiland KM, Lange C, Palmer LJ, Lazarus R, Vercelli D, Kwiatkowski DJ, Silverman EK, Martinez FD, Hudson TJ, Weiss ST
Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes. Am J Respir Crit Care Med. 2002 Dec 01; 166(11):1449-56.
Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes.
Heid IM, Huth C, Loos RJ, Kronenberg F, Adamkova V, Anand SS, Ardlie K, Biebermann H, Bjerregaard P, Boeing H, Bouchard C, Ciullo M, Cooper JA, Corella D, Dina C, Engert JC, Fisher E, Francès F, Froguel P, Hebebrand J, Hegele RA, Hinney A, Hoehe MR, Hu FB, Hubacek JA, Humphries SE, Hunt SC, Illig T, Järvelin MR, Kaakinen M, Kollerits B, Krude H, Kumar J, Lange LA, Langer B, Li S, Luchner A, Lyon HN, Meyre D, Mohlke KL, Mooser V, Nebel A, Nguyen TT, Paulweber B, Perusse L, Qi L, Rankinen T, Rosskopf D, Schreiber S, Sengupta S, Sorice R, Suk A, Thorleifsson G, Thorsteinsdottir U, Völzke H, Vimaleswaran KS, Wareham NJ, Waterworth D, Yusuf S, Lindgren C, McCarthy MI, Lange C, Hirschhorn JN, Laird N, Wichmann HE
Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design? PLoS Genet. 2009 Oct; 5(10):e1000694.
Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?
Krummel B, Strassburg A, Ernst M, Reiling N, Eker B, Rath H, Hoerster R, Wappler W, Glaewe A, Schoellhorn V, Sotgiu G, Lange C
Potential role for IL-2 ELISpot in differentiating recent and remote infection in tuberculosis contact tracing. PLoS One. 2010 Jul 20; 5(7):e11670.
Potential role for IL-2 ELISpot in differentiating recent and remote infection in tuberculosis contact tracing.
Randolph AG, Lange C, Silverman EK, Lazarus R, Weiss ST
Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes. Am J Respir Crit Care Med. 2005 Sep 15; 172(6):687-92.
Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes.
Lasky-Su J, Lyon HN, Emilsson V, Heid IM, Molony C, Raby BA, Lazarus R, Klanderman B, Soto-Quiros ME, Avila L, Silverman EK, Thorleifsson G, Thorsteinsdottir U, Kronenberg F, Vollmert C, Illig T, Fox CS, Levy D, Laird N, Ding X, McQueen MB, Butler J, Ardlie K, Papoutsakis C, Dedoussis G, O'Donnell CJ, Wichmann HE, Celedón JC, Schadt E, Hirschhorn J, Weiss ST, Stefansson K, Lange C
On the replication of genetic associations: timing can be everything! Am J Hum Genet. 2008 Apr; 82(4):849-58.
On the replication of genetic associations: timing can be everything!
Screening and replication using the same data set: testing strategies for family-based studies in which all probands are affected. PLoS Genet. 2008 Sep 19; 4(9):e1000197.
Screening and replication using the same data set: testing strategies for family-based studies in which all probands are affected.
Common genetic variation in the GAD1 gene and the entire family of DLX homeobox genes and autism spectrum disorders. Am J Med Genet B Neuropsychiatr Genet. 2011 Mar; 156(2):233-9.
Common genetic variation in the GAD1 gene and the entire family of DLX homeobox genes and autism spectrum disorders.
Causation and causal inference for genetic effects. Hum Genet. 2012 Oct; 131(10):1665-76.
Causation and causal inference for genetic effects.
European psychiatry : the journal of the Association of European Psychiatrists
Statistical challenges for genome-wide association studies of suicidality using family data. Eur Psychiatry. 2010 Jun; 25(5):307-9.
Statistical challenges for genome-wide association studies of suicidality using family data.
Uciechowski P, Imhoff H, Lange C, Meyer CG, Browne EN, Kirsten DK, Schröder AK, Schaaf B, Al-Lahham A, Reinert RR, Reiling N, Haase H, Hatzmann A, Fleischer D, Heussen N, Kleines M, Rink L
Susceptibility to tuberculosis is associated with TLR1 polymorphisms resulting in a lack of TLR1 cell surface expression. J Leukoc Biol. 2011 Aug; 90(2):377-88.
Susceptibility to tuberculosis is associated with TLR1 polymorphisms resulting in a lack of TLR1 cell surface expression.
Lasky-Su J, Himes BE, Raby BA, Klanderman BJ, Sylvia JS, Lange C, Melen E, Martinez FD, Israel E, Gauderman J, Gilliland F, Sleiman P, Hakonarson H, Celedón JC, Soto-Quiros M, Avila L, Lima JJ, Irvin CG, Peters SP, Boushey H, Chinchilli VM, Mauger D, Tantisira K, Weiss ST
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
HLA-DQ strikes again: genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults. Clin Exp Allergy. 2012 Dec; 42(12):1724-33.
HLA-DQ strikes again: genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults.
Hunninghake GM, Soto-Quirós ME, Avila L, Su J, Murphy A, Demeo DL, Ly NP, Liang C, Sylvia JS, Klanderman BJ, Lange C, Raby BA, Silverman EK, Celedón JC
Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood. J Allergy Clin Immunol. 2007 Jul; 120(1):84-90.
Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood.
McQueen MB, Bertram L, Lange C, Becker KD, Albert MS, Tanzi RE, Blacker D
Exploring candidate gene associations with neuropsychological performance. Am J Med Genet B Neuropsychiatr Genet. 2007 Dec 05; 144B(8):987-91.
Exploring candidate gene associations with neuropsychological performance.
Ionita-Laza I, McQueen MB, Laird NM, Lange C
Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan. Am J Hum Genet. 2007 Sep; 81(3):607-14.
Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan.
Recommendations for using standardised phenotypes in genetic association studies. Hum Genomics. 2009 Jul; 3(4):308-19.
Recommendations for using standardised phenotypes in genetic association studies.
Murphy A, Won S, Rogers A, Chu JH, Raby BA, Lange C
On the genome-wide analysis of copy number variants in family-based designs: methods for combining family-based and population-based information for testing dichotomous or quantitative traits, or completely ascertained samples. Genet Epidemiol. 2010 Sep; 34(6):582-90.
On the genome-wide analysis of copy number variants in family-based designs: methods for combining family-based and population-based information for testing dichotomous or quantitative traits, or completely ascertained samples.
Quantitative trait prediction based on genetic marker-array data, a simulation study. Bioinformatics. 2011 Mar 15; 27(6):745-8.
Quantitative trait prediction based on genetic marker-array data, a simulation study.
PolyGEE: a generalized estimating equation approach to the efficient and robust estimation of polygenic effects in large-scale association studies. Biostatistics. 2018 07 01; 19(3):295-306.
PolyGEE: a generalized estimating equation approach to the efficient and robust estimation of polygenic effects in large-scale association studies.
Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, Ramasamy K, Mullin K, Menon R, Sampson AJ, Hsiao MY, Elliott KJ, Velicelebi G, Moscarillo T, Hyman BT, Wagner SL, Becker KD, Blacker D, Tanzi RE
Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med. 2005 Mar 03; 352(9):884-94.
Family-based association between Alzheimer's disease and variants in UBQLN1.
Lange CG, Xu Z, Patterson BK, Medvik K, Harnisch B, Asaad R, Valdez H, Lee SJ, Landay A, Lieberman J, Lederman MM
Proliferation responses to HIVp24 during antiretroviral therapy do not reflect improved immune phenotype or function. AIDS. 2004 Mar 05; 18(4):605-13.
Proliferation responses to HIVp24 during antiretroviral therapy do not reflect improved immune phenotype or function.
Raby BA, Silverman EK, Kwiatkowski DJ, Lange C, Lazarus R, Weiss ST
ADAM33 polymorphisms and phenotype associations in childhood asthma. J Allergy Clin Immunol. 2004 Jun; 113(6):1071-8.
ADAM33 polymorphisms and phenotype associations in childhood asthma.
Raby BA, Lazarus R, Silverman EK, Lake S, Lange C, Wjst M, Weiss ST
Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med. 2004 Nov 15; 170(10):1057-65.
Association of vitamin D receptor gene polymorphisms with childhood and adult asthma.
McQueen MB, Murphy A, Kraft P, Su J, Lazarus R, Laird NM, Lange C, Van Steen K
Comparison of linkage and association strategies for quantitative traits using the COGA dataset. BMC Genet. 2005 Dec 30; 6 Suppl 1:S96.
Comparison of linkage and association strategies for quantitative traits using the COGA dataset.
Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, Illig T, Wichmann HE, Meitinger T, Hunter D, Hu FB, Colditz G, Hinney A, Hebebrand J, Koberwitz K, Zhu X, Cooper R, Ardlie K, Lyon H, Hirschhorn JN, Laird NM, Lenburg ME, Lange C, Christman MF
A common genetic variant is associated with adult and childhood obesity. Science. 2006 Apr 14; 312(5771):279-83.
A common genetic variant is associated with adult and childhood obesity.
Lyon HN, Emilsson V, Hinney A, Heid IM, Lasky-Su J, Zhu X, Thorleifsson G, Gunnarsdottir S, Walters GB, Thorsteinsdottir U, Kong A, Gulcher J, Nguyen TT, Scherag A, Pfeufer A, Meitinger T, Brönner G, Rief W, Soto-Quiros ME, Avila L, Klanderman B, Raby BA, Silverman EK, Weiss ST, Laird N, Ding X, Groop L, Tuomi T, Isomaa B, Bengtsson K, Butler JL, Cooper RS, Fox CS, O'Donnell CJ, Vollmert C, Celedón JC, Wichmann HE, Hebebrand J, Stefansson K, Lange C, Hirschhorn JN
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet. 2007 Apr 27; 3(4):e61.
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.
Power calculations for a general class of family-based association tests: dichotomous traits. Am J Hum Genet. 2002 Sep; 71(3):575-84.
Power calculations for a general class of family-based association tests: dichotomous traits.
Hecker J, Xu X, Townes FW, Loehlein Fier H, Corcoran C, Laird N, Lange C
Family-based tests for associating haplotypes with general phenotype data: Improving the FBAT-haplotype algorithm. Genet Epidemiol. 2018 02; 42(1):123-126.
Family-based tests for associating haplotypes with general phenotype data: Improving the FBAT-haplotype algorithm.
Naylor MG, Lin X, Weiss ST, Raby BA, Lange C
Using canonical correlation analysis to discover genetic regulatory variants. PLoS One. 2010 May 13; 5(5):e10395.
Using canonical correlation analysis to discover genetic regulatory variants.
Lipman PJ, Liu KY, Muehlschlegel JD, Body S, Lange C
Inferring genetic causal effects on survival data with associated endo-phenotypes. Genet Epidemiol. 2011 Feb; 35(2):119-24.
Inferring genetic causal effects on survival data with associated endo-phenotypes.
Ionita-Laza I, Buxbaum JD, Laird NM, Lange C
A new testing strategy to identify rare variants with either risk or protective effect on disease. PLoS Genet. 2011 Feb 03; 7(2):e1001289.
A new testing strategy to identify rare variants with either risk or protective effect on disease.
PBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies. Hum Genomics. 2005 Mar; 2(1):67-9.
PBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies.
McQueen MB, Devlin B, Faraone SV, Nimgaonkar VL, Sklar P, Smoller JW, Abou Jamra R, Albus M, Bacanu SA, Baron M, Barrett TB, Berrettini W, Blacker D, Byerley W, Cichon S, Coryell W, Craddock N, Daly MJ, Depaulo JR, Edenberg HJ, Foroud T, Gill M, Gilliam TC, Hamshere M, Jones I, Jones L, Juo SH, Kelsoe JR, Lambert D, Lange C, Lerer B, Liu J, Maier W, Mackinnon JD, McInnis MG, McMahon FJ, Murphy DL, Nothen MM, Nurnberger JI, Pato CN, Pato MT, Potash JB, Propping P, Pulver AE, Rice JP, Rietschel M, Scheftner W, Schumacher J, Segurado R, Van Steen K, Xie W, Zandi PP, Laird NM
Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet. 2005 Oct; 77(4):582-95.
Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.
Demeo DL, Mariani TJ, Lange C, Srisuma S, Litonjua AA, Celedon JC, Lake SL, Reilly JJ, Chapman HA, Mecham BH, Haley KJ, Sylvia JS, Sparrow D, Spira AE, Beane J, Pinto-Plata V, Speizer FE, Shapiro SD, Weiss ST, Silverman EK
The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet. 2006 Feb; 78(2):253-64.
Rakovski CS, Weiss ST, Laird NM, Lange C
FBAT-SNP-PC: an approach for multiple markers and single trait in family-based association tests. Hum Hered. 2008; 66(2):122-6.
FBAT-SNP-PC: an approach for multiple markers and single trait in family-based association tests.
Fox AA, Collard CD, Shernan SK, Seidman CE, Seidman JG, Liu KY, Muehlschlegel JD, Perry TE, Aranki SF, Lange C, Herman DS, Meitinger T, Lichtner P, Body SC
Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. Anesthesiology. 2009 Apr; 110(4):738-47.
Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.
Rogers AJ, Raby BA, Lima J, Lasky-Su JA, Murphy A, Lazarus R, Klanderman B, Sylvia JS, Ziniti JP, Lange C, Celedón JC, Silverman EK, Weiss ST
Stronger evidence for replication of NPPA using genome-wide genotyping data. Am J Respir Crit Care Med. 2010 Jan 01; 181(1):96.
Stronger evidence for replication of NPPA using genome-wide genotyping data.
A doubly robust test for gene-environment interaction in family-based studies of affected offspring. Biostatistics. 2010 Apr; 11(2):213-25.
A doubly robust test for gene-environment interaction in family-based studies of affected offspring.
CGene: an R package for implementation of causal genetic analyses. Eur J Hum Genet. 2011 Dec; 19(12):1292-4.
CGene: an R package for implementation of causal genetic analyses.
Murphy A, Chu JH, Xu M, Carey VJ, Lazarus R, Liu A, Szefler SJ, Strunk R, Demuth K, Castro M, Hansel NN, Diette GB, Vonakis BM, Adkinson NF, Klanderman BJ, Senter-Sylvia J, Ziniti J, Lange C, Pastinen T, Raby BA
Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes. Hum Mol Genet. 2010 Dec 01; 19(23):4745-57.
Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes.
Sebro R, Hoffman TJ, Lange C, Rogus JJ, Risch NJ
Testing for non-random mating: evidence for ancestry-related assortative mating in the Framingham heart study. Genet Epidemiol. 2010 Nov; 34(7):674-9.
Testing for non-random mating: evidence for ancestry-related assortative mating in the Framingham heart study.
Rogers AJ, Raby BA, Lasky-Su JA, Murphy A, Lazarus R, Klanderman BJ, Sylvia JS, Ziniti JP, Lange C, Celedón JC, Silverman EK, Weiss ST
Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. Am J Respir Crit Care Med. 2009 Jun 15; 179(12):1084-90.
Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.
Jafari C, Thijsen S, Sotgiu G, Goletti D, Domínguez Benítez JA, Losi M, Eberhardt R, Kirsten D, Kalsdorf B, Bossink A, Latorre I, Migliori GB, Strassburg A, Winteroll S, Greinert U, Richeldi L, Ernst M, Lange C
Bronchoalveolar lavage enzyme-linked immunospot for a rapid diagnosis of tuberculosis: a Tuberculosis Network European Trialsgroup study. Am J Respir Crit Care Med. 2009 Oct 01; 180(7):666-73.
Bronchoalveolar lavage enzyme-linked immunospot for a rapid diagnosis of tuberculosis: a Tuberculosis Network European Trialsgroup study.
Poon AH, Tantisira KG, Litonjua AA, Lazarus R, Xu J, Lasky-Su J, Lima JJ, Irvin CG, Hanrahan JP, Lange C, Weiss ST
Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma. Pharmacogenet Genomics. 2008 May; 18(5):373-82.
Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma.
Ionita-Laza I, Laird NM, Raby BA, Weiss ST, Lange C
On the frequency of copy number variants. Bioinformatics. 2008 Oct 15; 24(20):2350-5.
On the frequency of copy number variants.
Himes BE, Lasky-Su J, Wu AC, Wilk JB, Hunninghake GM, Klanderman B, Murphy AJ, Lazarus R, Soto-Quiros ME, Avila L, Celedón JC, Lange C, O'Connor GT, Raby BA, Silverman EK, Weiss ST
Asthma-susceptibility variants identified using probands in case-control and family-based analyses. BMC Med Genet. 2010 Aug 10; 11:122.
Asthma-susceptibility variants identified using probands in case-control and family-based analyses.
Mühleisen TW, Mattheisen M, Strohmaier J, Degenhardt F, Priebe L, Schultz CC, Breuer R, Meier S, Hoffmann P, Rivandeneira F, Hofman A, Uitterlinden AG, Moebus S, Gieger C, Emeny R, Ladwig KH, Wichmann HE, Schwarz M, Kammerer-Ciernioch J, Schlösser RG, Nenadic I, Sauer H, Mössner R, Maier W, Rujescu D, Lange C, Ophoff RA, Schulze TG, Rietschel M, Nöthen MM, Cichon S
Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder. Schizophr Res. 2012 Jun; 138(1):69-73.
Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder.
Fier H, Won S, Prokopenko D, AlChawa T, Ludwig KU, Fimmers R, Silverman EK, Pagano M, Mangold E, Lange C
'Location, Location, Location': a spatial approach for rare variant analysis and an application to a study on non-syndromic cleft lip with or without cleft palate. Bioinformatics. 2012 Dec 01; 28(23):3027-33.
'Location, Location, Location': a spatial approach for rare variant analysis and an application to a study on non-syndromic cleft lip with or without cleft palate.
Lange C, Silverman EK, Xu X, Weiss ST, Laird NM
A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics. 2003 Apr; 4(2):195-206.
A multivariate family-based association test using generalized estimating equations: FBAT-GEE.
DeMeo DL, Celedón JC, Lange C, Reilly JJ, Chapman HA, Sylvia JS, Speizer FE, Weiss ST, Silverman EK
Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004 Dec 15; 170(12):1294-301.
Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease.
Ludwig KU, Mangold E, Herms S, Nowak S, Reutter H, Paul A, Becker J, Herberz R, AlChawa T, Nasser E, Böhmer AC, Mattheisen M, Alblas MA, Barth S, Kluck N, Lauster C, Braumann B, Reich RH, Hemprich A, Pötzsch S, Blaumeiser B, Daratsianos N, Kreusch T, Murray JC, Marazita ML, Ruczinski I, Scott AF, Beaty TH, Kramer FJ, Wienker TF, Steegers-Theunissen RP, Rubini M, Mossey PA, Hoffmann P, Lange C, Cichon S, Propping P, Knapp M, Nöthen MM
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. Nat Genet. 2012 Sep; 44(9):968-71.
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.