KS14Kai-ChristianSonntagKai-Christian Sonntag, M.D., Ph.D.42.39465440000000-71.1956711000000046475Sonntag, Kai-Christian617/855-3138Assistant Professor of Psychiatrycatalyst:advisorInMentoringCurrentStudentOpportunitycurrent student opportunitiescatalyst:eCommonsLogineCommons LoginMentoring - Current Student Opportunityprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:overviewoverviewvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlevivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson11020796Sonntag KC, Haller GW, Giauffret D, Germana S, Reeves SA, Levy J, Sachs DH, LeGuern CHuman gene therapyRegulated expression of an MHC class II gene from a promoter-inducible retrovirus. Hum Gene Ther. 2000 Sep 20; 11(14):1961-9.Hum Gene Ther2000-09-20T00:00:002000Regulated expression of an MHC class II gene from a promoter-inducible retrovirus.Authorship 1050155129496145Sonntag KC, Woo TWHandbook of clinical neurologyLaser microdissection and gene expression profiling in the human postmortem brain. Handb Clin Neurol. 2018; 150:263-272.Handb Clin Neurol2018-01-01T00:00:002018Laser microdissection and gene expression profiling in the human postmortem brain.16331413Wang YP, Zhao XX, Sonntag K, Wehling P, Snowdon RJChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biologyBehaviour of Sinapis alba chromosomes in a Brassica napus background revealed by genomic in-situ hybridization. Chromosome Res. 2005; 13(8):819-26.Chromosome Res2005-12-08T00:00:002005Behaviour of Sinapis alba chromosomes in a Brassica napus background revealed by genomic in-situ hybridization.Authorship 10581001Authorship 1058165429635114Kohlbrenner EA, Shaskan N, Pietersen CY, Sonntag KC, Woo TWJournal of psychiatric researchGene expression profile associated with postnatal development of pyramidal neurons in the human prefrontal cortex implicates ubiquitin ligase E3 in the pathophysiology of schizophrenia onset. J Psychiatr Res. 2018 07; 102:110-117.J Psychiatr Res2018-04-03T00:00:002018Gene expression profile associated with postnatal development of pyramidal neurons in the human prefrontal cortex implicates ubiquitin ligase E3 in the pathophysiology of schizophrenia onset.29653250Sonntag KC, Song B, Lee N, Jung JH, Cha Y, Leblanc P, Neff C, Kong SW, Carter BS, Schweitzer J, Kim KSProgress in neurobiologyPluripotent stem cell-based therapy for Parkinson's disease: Current status and future prospects. Prog Neurobiol. 2018 09; 168:1-20.Prog Neurobiol2018-04-11T00:00:002018Pluripotent stem cell-based therapy for Parkinson's disease: Current status and future prospects.22178324Sonntag KC, Woo TU, Krichevsky AMExperimental neurologyConverging miRNA functions in diverse brain disorders: a case for miR-124 and miR-126. Exp Neurol. 2012 Jun; 235(2):427-35.Exp Neurol2011-12-08T00:00:002011Converging miRNA functions in diverse brain disorders: a case for miR-124 and miR-126.7698884Sonntag KC, Schnitzler P, Janssen W, Darai GIntervirologyIdentification of the primary structure and the coding capacity of the genome of insect iridescent virus type 6 between the genome coordinates 0.310 and 0.347 (7990 bp). Intervirology. 1994; 37(5):287-97.Intervirology1994-01-01T00:00:001994Identification of the primary structure and the coding capacity of the genome of insect iridescent virus type 6 between the genome coordinates 0.310 and 0.347 (7990 bp).19052140Simunovic F, Yi M, Wang Y, Macey L, Brown LT, Krichevsky AM, Andersen SL, Stephens RM, Benes FM, Sonntag KCBrain : a journal of neurologyGene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology. Brain. 2009 Jul; 132(Pt 7):1795-809.Brain2008-12-03T00:00:002008Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology.12687349Wang YP, Sonntag K, Rudloff ETAG. Theoretical and applied genetics. Theoretische und angewandte GenetikDevelopment of rapeseed with high erucic acid content by asymmetric somatic hybridization between Brassica napus and Crambe abyssinica. Theor Appl Genet. 2003 May; 106(7):1147-55.Theor Appl Genet2003-04-10T00:00:002003Development of rapeseed with high erucic acid content by asymmetric somatic hybridization between Brassica napus and Crambe abyssinica.21761317Pietersen CY, Lim MP, Macey L, Woo TU, Sonntag KCMethods in molecular biology (Clifton, N.J.)Neuronal type-specific gene expression profiling and laser-capture microdissection. Methods Mol Biol. 2011; 755:327-43.Methods Mol Biol2011-01-01T00:00:002011Neuronal type-specific gene expression profiling and laser-capture microdissection.Sonntag, K.-C. Identification and Characterization of the Origin of DNA Replication CIV-ori-M and the Transcriptional Activity of Insect Iridescent Virus Type 6 Between the Genome-Coordinates 0.310 to 0.347 (7990 bp)Identification and Characterization of the Origin of DNA Replication CIV-ori-M and the Transcriptional Activity of Insect Iridescent Virus Type 6 Between the Genome-Coordinates 0.310 to 0.347 (7990 bp). 1994.1994-01-01T00:00:001994Identification and Characterization of the Origin of DNA Replication CIV-ori-M and the Transcriptional Activity of Insect Iridescent Virus Type 6 Between the Genome-Coordinates 0.310 to 0.347 (7990 bp)Authorship 10800851229982852El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AMActa neuropathologicaMicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. Acta Neuropathol. 2018 10; 136(4):537-555.Acta Neuropathol2018-07-07T00:00:002018MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways.20380815Sonntag KCBrain researchMicroRNAs and deregulated gene expression networks in neurodegeneration. Brain Res. 2010 Jun 18; 1338:48-57.Brain Res2010-04-07T00:00:002010MicroRNAs and deregulated gene expression networks in neurodegeneration.20380824Sonntag KC, Wahlestedt CBrain researchRNA mechanisms in CNS systems and disorders. Brain Res. 2010 Jun 18; 1338:1-2.Brain Res2010-04-07T00:00:002010RNA mechanisms in CNS systems and disorders.17327906Seo H, Sonntag KC, Kim W, Cattaneo E, Isacson OPloS oneProteasome activator enhances survival of Huntington's disease neuronal model cells. PLoS One. 2007 Feb 28; 2(2):e238.PLoS One2007-02-28T00:00:002007Proteasome activator enhances survival of Huntington's disease neuronal model cells.18588536Andersen SL, Napierata L, Brenhouse HC, Sonntag KCThe European journal of neuroscienceJuvenile methylphenidate modulates reward-related behaviors and cerebral blood flow by decreasing cortical D3 receptors. Eur J Neurosci. 2008 Jun; 27(11):2962-72.Eur J Neurosci2008-06-01T00:00:002008Juvenile methylphenidate modulates reward-related behaviors and cerebral blood flow by decreasing cortical D3 receptors.7618282Sonntag KC, Clauer U, Bugert JJ, Schnitzler P, Darai GVirologyIdentification and properties of the genes encoding the poly(A) polymerase and a small (22 kDa) and the largest subunit (147 kDa) of the DNA-dependent RNA polymerase of molluscum contagiosum virus. Virology. 1995 Jul 10; 210(2):471-8.Virology1995-07-10T00:00:001995Identification and properties of the genes encoding the poly(A) polymerase and a small (22 kDa) and the largest subunit (147 kDa) of the DNA-dependent RNA polymerase of molluscum contagiosum virus.16869113Sonntag KC, Sanchez-Pernaute RCurrent opinion in investigational drugs (London, England : 2000)Tailoring human embryonic stem cells for neurodegenerative disease therapy. Curr Opin Investig Drugs. 2006 Jul; 7(7):614-8.Curr Opin Investig Drugs2006-07-01T00:00:002006Tailoring human embryonic stem cells for neurodegenerative disease therapy.17615270Brunlid G, Pruszak J, Holmes B, Isacson O, Sonntag KCStem cells (Dayton, Ohio)Immature and neurally differentiated mouse embryonic stem cells do not express a functional Fas/Fas ligand system. Stem Cells. 2007 Oct; 25(10):2551-8.Stem Cells2007-07-05T00:00:002007Immature and neurally differentiated mouse embryonic stem cells do not express a functional Fas/Fas ligand system.20111594Simunovic F, Yi M, Wang Y, Stephens R, Sonntag KCPloS oneEvidence for gender-specific transcriptional profiles of nigral dopamine neurons in Parkinson disease. PLoS One. 2010 Jan 25; 5(1):e8856.PLoS One2010-01-25T00:00:002010Evidence for gender-specific transcriptional profiles of nigral dopamine neurons in Parkinson disease.8828152Sonntag KC, Darai GVirus genesEvolution of viral DNA-dependent RNA polymerases. Virus Genes. 1995; 11(2-3):271-84.Virus Genes1995-01-01T00:00:001995Evolution of viral DNA-dependent RNA polymerases.16357340Krichevsky AM, Sonntag KC, Isacson O, Kosik KSStem cells (Dayton, Ohio)Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells. 2006 Apr; 24(4):857-64.Stem Cells2005-12-15T00:00:002005Specific microRNAs modulate embryonic stem cell-derived neurogenesis.Authorship 1125672D020869Concepts & IdeasGenes & Molecular SequencesProcedures290093870.309717Gene Expression ProfilingD004298Chemicals & Drugs58715970.570566DopamineD035683Chemicals & Drugs138637120.311762MicroRNAsD009474Anatomy222293360.24715NeuronsD010300Disorders74127800.359725Parkinson DiseaseNeurologyPsychiatryBrigham and Women's HospitalBoston Children's HospitalHarvard Medical SchoolMass Mental Health CenterMassachusetts General HospitalMcLean HospitalMAS9MichaelSchwarzschildMichael A. Schwarzschild, M.D., Ph.D.42.37904200000000-71.0514810000000019322Schwarzschild, MichaelJulieanne Dorn Professor of NeurologyOSI1OleIsacsonOle Isacson, Dr.Med.Sci, M.B.42.39465440000000-71.1956711000000016740Isacson, OleProfessor of NeurologyDJS1DennisSelkoeDennis J. Selkoe, M.D.42.33837200000000-71.1032690000000081795Selkoe, DennisVincent and Stella Coates Professor of Neurologic Diseases in the Department of NeurologySEL4ScottLukasScott E. Lukas, Ph.D.42.39465440000000-71.1956711000000049987Lukas, ScottProfessor of PsychiatrySLA4SusanAndersenSusan Laura Andersen, Ph.D.42.39465440000000-71.1956711000000056543Andersen, SusanLecturer on Psychiatry, Part-timeTWW3Tsung-UngWooTsung-Ung Wilson Woo, M.D., Ph.D.42.39465440000000-71.1956711000000067917Woo, Tsung-UngAssistant Professor of Psychiatry, Part-timeSBC3BarakCaineBarak Caine, Ph.D.42.39465440000000-71.1956711000000039846Caine, BarakLecturer on Psychiatry, Part-timeIW4IgorWeinbergIgor Weinberg, Ph.D.42.39465440000000-71.1956711000000078100Weinberg, IgorAssistant Professor of Psychology in the Department of PsychiatryBMC1BruceCohenBruce Michael Cohen, M.D.,Ph.D.42.39465440000000-71.1956711000000025041Cohen, BruceRobertson-Steele Professor of PsychiatryBTH2BradleyHymanBradley Theodore Hyman, M.D., Ph.D.42.37904200000000-71.051481000000004393Hyman, BradleyJohn B. Penney, Jr. Professor of NeurologyGQD1GeorgeDaleyGeorge Quentin Daley, M.D., Ph.D.42.33812600000000-71.1049210000000062Daley, GeorgeCaroline Shields Walker Professor of Medicine1174selected publications1.150850.00317158403research areas2.489810.031336126coauthor of43.75528.6693760similar toMGC1MilesCunninghamMiles Gregory Cunningham, M.D., Ph.D.42.39465440000000-71.1956711000000034869Cunningham, MilesAssistant Professor of PsychiatryGMT3GailTsimpreaGail M. Tsimprea, Ph.D.42.39465440000000-71.195671100000001000Tsimprea, GailInstructor in PsychiatryAK12AnnaKrichevskyAnna Krichevsky, Ph.D.42.33837200000000-71.1032690000000070871Krichevsky, AnnaAssociate Professor of NeurologyAuthorship 1188144531485508Meda S, Freund N, Norman KJ, Thompson BS, Sonntag KC, Andersen SLHeliyonThe use of laser capture microdissection to identify specific pathways and mechanisms involved in impulsive choice in rats. Heliyon. 2019 Aug; 5(8):e02254.Heliyon2019-08-23T00:00:002019The use of laser capture microdissection to identify specific pathways and mechanisms involved in impulsive choice in rats.true1Assistant Professor of PsychiatryAssistant Professor of Psychiatrytrue1Julieanne Dorn Professor of NeurologyJulieanne Dorn Professor of Neurologytrue1Assistant Professor of Psychology in the Department of PsychiatryAssistant Professor of Psychology in the Department of Psychiatrytrue1John B. Penney, Jr. Professor of NeurologyJohn B. Penney, Jr. Professor of Neurologytrue1Robertson-Steele Professor of PsychiatryRobertson-Steele Professor of Psychiatrytrue1Instructor in PsychiatryInstructor in Psychiatrytrue1Associate Professor of NeurologyAssociate Professor of Neurologytrue1Assistant Professor of PsychiatryAssistant Professor of Psychiatrytrue1Professor of NeurologyProfessor of Neurologytrue1Vincent and Stella Coates Professor of Neurologic Diseases in the Department of NeurologyVincent and Stella Coates Professor of Neurologic Diseases in the Department of NeurologyAuthorship 1772611Authorship 1795185Authorship 1255102532526727Jeong YI, Kim T, Hwang EJ, Kim SW, Sonntag KC, Kim DH, Koh JWBiomedical materials (Bristol, England)Reactive oxygen species-sensitive nanophotosensitizers of aminophenyl boronic acid pinacol ester conjugated chitosan-g-methoxy poly(ethylene glycol) copolymer for photodynamic treatment of cancer. Biomed Mater. 2020 08 31; 15(5):055034.Biomed Mater2020-08-31T00:00:002020Reactive oxygen species-sensitive nanophotosensitizers of aminophenyl boronic acid pinacol ester conjugated chitosan-g-methoxy poly(ethylene glycol) copolymer for photodynamic treatment of cancer.BCMPAuthorship 1349001933863993Ryu WI, Bormann MK, Shen M, Kim D, Forester B, Park Y, So J, Seo H, Sonntag KC, Cohen BMMolecular psychiatryBrain cells derived from Alzheimer's disease patients have multiple specific innate abnormalities in energy metabolism. Mol Psychiatry. 2021 10; 26(10):5702-5714.Mol Psychiatry2021-04-16T00:00:002021Brain cells derived from Alzheimer's disease patients have multiple specific innate abnormalities in energy metabolism.Authorship 2491211Authorship 1606455Authorship 1386620334395428Ryu WI, Cohen BM, Sonntag KCFrontiers in cell and developmental biologyHypothesis and Theory: Characterizing Abnormalities of Energy Metabolism Using a Cellular Platform as a Personalized Medicine Approach for Alzheimer's Disease. Front Cell Dev Biol. 2021; 9:697578.Front Cell Dev Biol2021-07-30T00:00:002021Hypothesis and Theory: Characterizing Abnormalities of Energy Metabolism Using a Cellular Platform as a Personalized Medicine Approach for Alzheimer's Disease.Authorship 1467436735730144Ryu WI, Shen M, Lee Y, Healy RA, Bormann MK, Cohen BM, Sonntag KCAging cellNicotinamide riboside and caffeine partially restore diminished NAD availability but not altered energy metabolism in Alzheimer's disease. Aging Cell. 2022 07; 21(7):e13658.Aging Cell2022-06-21T00:00:002022Nicotinamide riboside and caffeine partially restore diminished NAD availability but not altered energy metabolism in Alzheimer's disease.Authorship 15540912025-01-02T00:00:002023-01-02T00:00:00Studying a role of bioenergetics in late-onset Alzheimer’s disease using a personalized medicine approachOur lab studies a role of bioenergetics in Alzheimer's disease (AD). It is well known that metabolic changes are associated with the normal aging process, and our research aims to understand how these changes are linked to sporadic/late-onset AD (LOAD) pathogenesis. For this, we have developed a cell-based platform using skin fibroblasts from LOAD patients and healthy control individuals and therefrom generated induced pluripotent stem cells (iPSC) which are differentiated to brain cells, including neural progenitor cells, neurons, and astrocytes. Using this platform, we assess the cells’ bioenergetic profiles, changes in metabolism, transcriptional profiles, membrane compositions, the effects of LOAD risk factors, and associated cellular functions, in context of cell development, cell type, age, and disease. The goal of our program is to establish a 'personalized medicine approach' aiming to understand AD pathogenesis and to develop biomarkers or testing novel therapeutic strategies. In addition to LOAD, we also use this cellular platform to study energy metabolism in schizophrenia (SZ) patients’-derived cells.
The student's project will be within the scope of the main studies with a focus on cellular bioenergetics and metabolic functions in the aging process and LOAD. In addition, we study other cell functions related to metabolic dysfunction in LOAD, the effects of LOAD risk factors like APOE, and we identify and test therapeutic molecules in our model system. The student will be involved in study design, experimental data generation, analyses, interpretation, and summarizing results in scientific reports. He/she will participate in and learn the principles of the cell platform and the iPSC paradigm in context of neuro-differentiation and -degeneration with a focus on AD or SZ. Some previous experiences working in a wet lab and in cell culture would be a benefit.Authorship 1514696236602534Cohen BM, Sonntag KCAgingThe complex determinants of Alzheimer's-type dementias. Aging (Albany NY). 2023 01 04; 15(1):1-3.Aging (Albany NY)2023-01-04T00:00:002023The complex determinants of Alzheimer's-type dementias.Authorship 4787763true1Professor of PsychiatryProfessor of Psychiatrytrue1Lecturer on Psychiatry, Part-timeLecturer on Psychiatry, Part-timeAuthorship 5339481true1Lecturer on Psychiatry, Part-timeLecturer on Psychiatry, Part-timetrue1Caroline Shields Walker Professor of MedicineCaroline Shields Walker Professor of Medicinetrue1Assistant Professor of Psychiatry, Part-timeAssistant Professor of Psychiatry, Part-timeAuthorship 3508006Authorship 2239651Authorship 7192182Authorship 72252111Authorship 721862124702465Pietersen CY, Mauney SA, Kim SS, Lim MP, Rooney RJ, Goldstein JM, Petryshen TL, Seidman LJ, Shenton ME, McCarley RW, Sonntag KC, Woo TUJournal of neurogeneticsMolecular profiles of pyramidal neurons in the superior temporal cortex in schizophrenia. J Neurogenet. 2014 Mar-Jun; 28(1-2):53-69.J Neurogenet2014-04-10T00:00:002014Molecular profiles of pyramidal neurons in the superior temporal cortex in schizophrenia.24628518Pietersen CY, Mauney SA, Kim SS, Passeri E, Lim MP, Rooney RJ, Goldstein JM, Petreyshen TL, Seidman LJ, Shenton ME, Mccarley RW, Sonntag KC, Woo TUJournal of neurogeneticsMolecular profiles of parvalbumin-immunoreactive neurons in the superior temporal cortex in schizophrenia. J Neurogenet. 2014 Mar-Jun; 28(1-2):70-85.J Neurogenet2014-03-17T00:00:002014Molecular profiles of parvalbumin-immunoreactive neurons in the superior temporal cortex in schizophrenia.24559646Kim W, Lee Y, McKenna ND, Yi M, Simunovic F, Wang Y, Kong B, Rooney RJ, Seo H, Stephens RM, Sonntag KCNeurobiology of agingmiR-126 contributes to Parkinson's disease by dysregulating the insulin-like growth factor/phosphoinositide 3-kinase signaling. Neurobiol Aging. 2014 Jul; 35(7):1712-21.Neurobiol Aging2014-01-24T00:00:002014miR-126 contributes to Parkinson's disease by dysregulating the insulin-like growth factor/phosphoinositide 3-kinase signaling.24408208Sonntag KC, Brenhouse HC, Freund N, Thompson BS, Puhl M, Andersen SLPsychopharmacologyViral over-expression of D1 dopamine receptors in the prefrontal cortex increase high-risk behaviors in adults: comparison with adolescents. Psychopharmacology (Berl). 2014 Apr; 231(8):1615-26.Psychopharmacology (Berl)2014-01-10T00:00:002014Viral over-expression of D1 dopamine receptors in the prefrontal cortex increase high-risk behaviors in adults: comparison with adolescents.24478696Andersen SL, Sonntag KCFrontiers in synaptic neuroscienceJuvenile methylphenidate reduces prefrontal cortex plasticity via D3 receptor and BDNF in adulthood. Front Synaptic Neurosci. 2014; 6:1.Front Synaptic Neurosci2014-01-21T00:00:002014Juvenile methylphenidate reduces prefrontal cortex plasticity via D3 receptor and BDNF in adulthood.Authorship 2200424Authorship 72986011Authorship 73008412Authorship 38118010Authorship 3446081Authorship 4133562Authorship 4706162Authorship 7545911125024431Aguila JC, Blak A, van Arensbergen J, Sousa A, Vázquez N, Aduriz A, Gayosso M, Lopez Mato MP, Lopez de Maturana R, Hedlund E, Sonntag KC, Sanchez-Pernaute RStem cells translational medicineSelection Based on FOXA2 Expression Is Not Sufficient to Enrich for Dopamine Neurons From Human Pluripotent Stem Cells. Stem Cells Transl Med. 2014 Sep; 3(9):1032-42.Stem Cells Transl Med2014-07-14T00:00:002014Selection Based on FOXA2 Expression Is Not Sufficient to Enrich for Dopamine Neurons From Human Pluripotent Stem Cells.Authorship 3769495Authorship 776234925458894Castaño J, Menendez P, Bruzos-Cidon C, Straccia M, Sousa A, Zabaleta L, Vazquez N, Zubiarrain A, Sonntag KC, Ugedo L, Carvajal-Vergara X, Canals JM, Torrecilla M, Sanchez-Pernaute R, Giorgetti AStem cell reportsFast and efficient neural conversion of human hematopoietic cells. Stem Cell Reports. 2014 Dec 09; 3(6):1118-31.Stem Cell Reports2014-11-13T00:00:002014Fast and efficient neural conversion of human hematopoietic cells.Authorship 3240683Authorship 4735991Authorship 5088943Authorship 4943112Authorship 600133Authorship 779052Authorship 942554Authorship 934772Authorship 3509641Authorship 3424961Authorship 4086633Authorship 932171Authorship 4551081Authorship 3485802Authorship 3867291Authorship 4446655Authorship 4989141Authorship 4692901Authorship 2851731Authorship 808942325749358Brenhouse HC, Thompson BS, Sonntag KC, Andersen SLNeuropharmacologyExtinction and reinstatement to cocaine-associated cues in male and female juvenile rats and the role of D1 dopamine receptor. Neuropharmacology. 2015 Aug; 95:22-8.Neuropharmacology2015-03-04T00:00:002015Extinction and reinstatement to cocaine-associated cues in male and female juvenile rats and the role of D1 dopamine receptor.26047984Briggs CE, Wang Y, Kong B, Woo TU, Iyer LK, Sonntag KCBrain researchMidbrain dopamine neurons in Parkinson's disease exhibit a dysregulated miRNA and target-gene network. Brain Res. 2015 Aug 27; 1618:111-21.Brain Res2015-06-03T00:00:002015Midbrain dopamine neurons in Parkinson's disease exhibit a dysregulated miRNA and target-gene network.Authorship 8223016Authorship 3666251Authorship 8453991025560761Frederick AL, Yano H, Trifilieff P, Vishwasrao HD, Biezonski D, Mészáros J, Urizar E, Sibley DR, Kellendonk C, Sonntag KC, Graham DL, Colbran RJ, Stanwood GD, Javitch JAMolecular psychiatryEvidence against dopamine D1/D2 receptor heteromers. Mol Psychiatry. 2015 Nov; 20(11):1373-85.Mol Psychiatry2015-01-06T00:00:002015Evidence against dopamine D1/D2 receptor heteromers.26585218Mauney SA, Pietersen CY, Sonntag KC, Woo TWSchizophrenia researchDifferentiation of oligodendrocyte precursors is impaired in the prefrontal cortex in schizophrenia. Schizophr Res. 2015 Dec; 169(1-3):374-380.Schizophr Res2015-11-14T00:00:002015Differentiation of oligodendrocyte precursors is impaired in the prefrontal cortex in schizophrenia.Authorship 8529353Authorship 8566911025407931Kim W, Noh H, Lee Y, Jeon J, Shanmugavadivu A, McPhie DL, Kim KS, Cohen BM, Seo H, Sonntag KCMolecular neurobiologyMiR-126 Regulates Growth Factor Activities and Vulnerability to Toxic Insult in Neurons. Mol Neurobiol. 2016 Jan; 53(1):95-108.Mol Neurobiol2014-11-19T00:00:002014MiR-126 Regulates Growth Factor Activities and Vulnerability to Toxic Insult in Neurons.Authorship 949691Authorship 872859326762379Freund N, Thompson BS, Sonntag K, Meda S, Andersen SLPsychopharmacologyWhen the party is over: depressive-like states in rats following termination of cortical D1 receptor overexpression. Psychopharmacology (Berl). 2016 Apr; 233(7):1191-201.Psychopharmacology (Berl)2016-01-14T00:00:002016When the party is over: depressive-like states in rats following termination of cortical D1 receptor overexpression.27062510Sonntag KC, Tejada G, Subburaju S, Berretta S, Benes FM, Woo TUJournal of neurochemistryLimited predictability of postmortem human brain tissue quality by RNA integrity numbers. J Neurochem. 2016 07; 138(1):53-9.J Neurochem2016-05-12T00:00:002016Limited predictability of postmortem human brain tissue quality by RNA integrity numbers.Authorship 5119173Authorship 88871412Assistant Professor1Associate Professor0Full Professor4Instructor3LecturerAuthorship 608652Authorship 5569881Authorship 976431Authorship 5586952Authorship 4405372Authorship 4735583Authorship 2027156Authorship 417942115737733Sonntag KC, Simantov R, Björklund L, Cooper O, Pruszak J, Kowalke F, Gilmartin J, Ding J, Hu YP, Shen MM, Isacson OMolecular and cellular neurosciencesContext-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells. Mol Cell Neurosci. 2005 Mar; 28(3):417-29.Mol Cell Neurosci2005-03-01T00:00:002005Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells.15790528Sonntag KC, Simantov R, Isacson OBrain research. Molecular brain researchStem cells may reshape the prospect of Parkinson's disease therapy. Brain Res Mol Brain Res. 2005 Mar 24; 134(1):34-51.Brain Res Mol Brain Res2005-03-24T00:00:002005Stem cells may reshape the prospect of Parkinson's disease therapy.Authorship 967378228236417Lukkes JL, Sonntag KC, Freund N, Thompson BS, Meda S, Andersen SLEuropean neuropsychopharmacology : the journal of the European College of NeuropsychopharmacologyErratum to "Preventative treatment in an animal model of DHD: Behavioral and biochemical effects of methylphenidate and its interactions with ovarian hormones in female rats" [Eur. Neuropsychopharmacol. 26 (2016) 1496-1506]. Eur Neuropsychopharmacol. 2016 11; 26(11):1843.Eur Neuropsychopharmacol2016-10-28T00:00:002016Erratum to "Preventative treatment in an animal model of DHD: Behavioral and biochemical effects of methylphenidate and its interactions with ovarian hormones in female rats" [Eur. Neuropsychopharmacol. 26 (2016) 1496-1506].1475907Sonntag KC, Darai GVirus genesCharacterization of the third origin of DNA replication of the genome of insect iridescent virus type 6. Virus Genes. 1992 Nov; 6(4):333-42.Virus Genes1992-11-01T00:00:001992Characterization of the third origin of DNA replication of the genome of insect iridescent virus type 6.15888489Chung CY, Seo H, Sonntag KC, Brooks A, Lin L, Isacson OHuman molecular geneticsCell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection. Hum Mol Genet. 2005 Jul 01; 14(13):1709-25.Hum Mol Genet2005-05-11T00:00:002005Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection.16131400Sonntag KCJournal of translational medicineImplementations of translational medicine. J Transl Med. 2005 Aug 30; 3:33.J Transl Med2005-08-30T00:00:002005Implementations of translational medicine.17038668Sonntag KC, Pruszak J, Yoshizaki T, van Arensbergen J, Sanchez-Pernaute R, Isacson OStem cells (Dayton, Ohio)Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin. Stem Cells. 2007 Feb; 25(2):411-8.Stem Cells2006-10-12T00:00:002006Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin.1549908Handermann M, Schnitzler P, Rösen-Wolff A, Raab K, Sonntag KC, Darai GVirus genesIdentification and mapping of origins of DNA replication within the DNA sequences of the genome of insect iridescent virus type 6. Virus Genes. 1992 Jan; 6(1):19-32.Virus Genes1992-01-01T00:00:001992Identification and mapping of origins of DNA replication within the DNA sequences of the genome of insect iridescent virus type 6.11897870Chung S, Andersson T, Sonntag KC, Björklund L, Isacson O, Kim KSStem cells (Dayton, Ohio)Analysis of different promoter systems for efficient transgene expression in mouse embryonic stem cell lines. Stem Cells. 2002; 20(2):139-45.Stem Cells2002-01-01T00:00:002002Analysis of different promoter systems for efficient transgene expression in mouse embryonic stem cell lines.12453046Chung S, Sonntag KC, Andersson T, Bjorklund LM, Park JJ, Kim DW, Kang UJ, Isacson O, Kim KSThe European journal of neuroscienceGenetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons. Eur J Neurosci. 2002 Nov; 16(10):1829-38.Eur J Neurosci2002-11-01T00:00:002002Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons.15016073Sonntag KC, Simantov R, Kim KS, Isacson OThe European journal of neuroscienceTemporally induced Nurr1 can induce a non-neuronal dopaminergic cell type in embryonic stem cell differentiation. Eur J Neurosci. 2004 Mar; 19(5):1141-52.Eur J Neurosci2004-03-01T00:00:002004Temporally induced Nurr1 can induce a non-neuronal dopaminergic cell type in embryonic stem cell differentiation.15349858Seo H, Sonntag KC, Isacson OAnnals of neurologyGeneralized brain and skin proteasome inhibition in Huntington's disease. Ann Neurol. 2004 Sep; 56(3):319-28.Ann Neurol2004-09-01T00:00:002004Generalized brain and skin proteasome inhibition in Huntington's disease.18704173Karki S, Pruszak J, Isacson O, Sonntag KCJournal of visualized experiments : JoVEES cell-derived neuroepithelial cell cultures. J Vis Exp. 2006 Nov 30; (1):118.J Vis Exp2006-11-30T00:00:002006ES cell-derived neuroepithelial cell cultures.8021587Schnitzler P, Sonntag KC, Müller M, Janssen W, Bugert JJ, Koonin EV, Darai GThe Journal of general virologyInsect iridescent virus type 6 encodes a polypeptide related to the largest subunit of eukaryotic RNA polymerase II. J Gen Virol. 1994 Jul; 75 ( Pt 7):1557-67.J Gen Virol1994-07-01T00:00:001994Insect iridescent virus type 6 encodes a polypeptide related to the largest subunit of eukaryotic RNA polymerase II.18669499Sanchez-Pernaute R, Lee H, Patterson M, Reske-Nielsen C, Yoshizaki T, Sonntag KC, Studer L, Isacson OBrain : a journal of neurologyParthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease. Brain. 2008 Aug; 131(Pt 8):2127-39.Brain2008-07-22T00:00:002008Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease.17588935Pruszak J, Sonntag KC, Aung MH, Sanchez-Pernaute R, Isacson OStem cells (Dayton, Ohio)Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations. Stem Cells. 2007 Sep; 25(9):2257-68.Stem Cells2007-06-21T00:00:002007Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations.20619828Andersen SL, Greene-Colozzi EA, Sonntag KCBiological psychiatryA novel, multiple symptom model of obsessive-compulsive-like behaviors in animals. Biol Psychiatry. 2010 Oct 15; 68(8):741-7.Biol Psychiatry2010-10-15T00:00:002010A novel, multiple symptom model of obsessive-compulsive-like behaviors in animals.Authorship 1006500728542144Chmielarz P, Konovalova J, Najam SS, Alter H, Piepponen TP, Erfle H, Sonntag KC, Schütz G, Vinnikov IA, Domanskyi ACell death & diseaseDicer and microRNAs protect adult dopamine neurons. Cell Death Dis. 2017 05 25; 8(5):e2813.Cell Death Dis2017-05-25T00:00:002017Dicer and microRNAs protect adult dopamine neurons.11134181Sonntag KC, Emery DW, Yasumoto A, Haller G, Germana S, Sablinski T, Shimizu A, Yamada K, Shimada H, Arn S, Sachs DH, LeGuern CThe Journal of clinical investigationTolerance to solid organ transplants through transfer of MHC class II genes. J Clin Invest. 2001 Jan; 107(1):65-71.J Clin Invest2001-01-01T00:00:002001Tolerance to solid organ transplants through transfer of MHC class II genes.8938977Sonntag KC, Darai GVirus genesStrategy for identifying the gene encoding the DNA polymerase of molluscum contagiosum virus type 1. Virus Genes. 1996; 13(1):31-44.Virus Genes1996-01-01T00:00:001996Strategy for identifying the gene encoding the DNA polymerase of molluscum contagiosum virus type 1.10515459Shimada H, Germana S, Sonntag KC, Banerjee P, Moore D, Sachs DH, LeGuern CHuman gene therapyMHC class II alpha/beta heterodimeric cell surface molecules expressed from a single proviral genome. Hum Gene Ther. 1999 Sep 20; 10(14):2397-405.Hum Gene Ther1999-09-20T00:00:001999MHC class II alpha/beta heterodimeric cell surface molecules expressed from a single proviral genome.115 Mill StMclean HospitalM R C 223115 Mill StBelmont02478MA15284877Wang YP, Snowdon RJ, Rudloff E, Wehling P, Friedt W, Sonntag KGenomeCytogenetic characterization and fae1 gene variation in progenies from asymmetric somatic hybrids between Brassica napus and Crambe abyssinica. Genome. 2004 Aug; 47(4):724-31.Genome2004-08-01T00:00:002004Cytogenetic characterization and fae1 gene variation in progenies from asymmetric somatic hybrids between Brassica napus and Crambe abyssinica.Authorship 1022030129070876Sonntag KC, Ryu WI, Amirault KM, Healy RA, Siegel AJ, McPhie DL, Forester B, Cohen BMScientific reportsLate-onset Alzheimer's disease is associated with inherent changes in bioenergetics profiles. Sci Rep. 2017 10 25; 7(1):14038.Sci Rep2017-10-25T00:00:002017Late-onset Alzheimer's disease is associated with inherent changes in bioenergetics profiles.18322084Brenhouse HC, Sonntag KC, Andersen SLThe Journal of neuroscience : the official journal of the Society for NeuroscienceTransient D1 dopamine receptor expression on prefrontal cortex projection neurons: relationship to enhanced motivational salience of drug cues in adolescence. J Neurosci. 2008 Mar 05; 28(10):2375-82.J Neurosci2008-03-05T00:00:002008Transient D1 dopamine receptor expression on prefrontal cortex projection neurons: relationship to enhanced motivational salience of drug cues in adolescence.11091496Sonntag KC, Nebhard N, Haller GW, Yasumoto A, Sachs DH, LeGuern CJournal of hematotherapy & stem cell researchAssessment of transduction rates of porcine bone marrow. J Hematother Stem Cell Res. 2000 Oct; 9(5):721-6.J Hematother Stem Cell Res2000-10-01T00:00:002000Assessment of transduction rates of porcine bone marrow.8073636Sonntag KC, Schnitzler P, Koonin EV, Darai GVirus genesChilo iridescent virus encodes a putative helicase belonging to a distinct family within the "DEAD/H" superfamily: implications for the evolution of large DNA viruses. Virus Genes. 1994 Mar; 8(2):151-8.Virus Genes1994-03-01T00:00:001994Chilo iridescent virus encodes a putative helicase belonging to a distinct family within the "DEAD/H" superfamily: implications for the evolution of large DNA viruses.20411787Sonntag KC, Simunovic F, Sanchez-Pernaute RJournal of neural transmission. SupplementumStem cells and cell replacement therapy for Parkinson's disease. J Neural Transm Suppl. 2009; (73):287-99.J Neural Transm Suppl2009-01-01T00:00:002009Stem cells and cell replacement therapy for Parkinson's disease.22190964Chartoff EH, Damez-Werno D, Sonntag KC, Hassinger L, Kaufmann DE, Peterson J, McPhie D, Cataldo AM, Cohen BMStem cells internationalDetection of intranasally delivered bone marrow-derived mesenchymal stromal cells in the lesioned mouse brain: a cautionary report. Stem Cells Int. 2011; 2011:586586.Stem Cells Int2011-11-15T00:00:002011Detection of intranasally delivered bone marrow-derived mesenchymal stromal cells in the lesioned mouse brain: a cautionary report.Authorship 1038530329344862Mauney SA, Woo TW, Sonntag KCMethods in molecular biology (Clifton, N.J.)Cell Type-Specific Laser Capture Microdissection for Gene Expression Profiling in the Human Brain. Methods Mol Biol. 2018; 1723:203-221.Methods Mol Biol2018-01-01T00:00:002018Cell Type-Specific Laser Capture Microdissection for Gene Expression Profiling in the Human Brain.7788188Sonntag KC, Schwarz-Eywill M, Hunstein WBritish journal of rheumatologyIs interferon alpha a therapy for hepatitis B-associated polyarteritis nodosa? Br J Rheumatol. 1995 May; 34(5):486-7.Br J Rheumatol1995-05-01T00:00:001995Is interferon alpha a therapy for hepatitis B-associated polyarteritis nodosa?14962292Matter-Reissmann UB, Sonntag KC, Gilli UO, Leguern C, Schneider MK, Seebach JDXenotransplantationHuman Fas-ligand expression on porcine endothelial cells does not protect against xenogeneic natural killer cytotoxicity. Xenotransplantation. 2004 Jan; 11(1):43-52.Xenotransplantation2004-01-01T00:00:002004Human Fas-ligand expression on porcine endothelial cells does not protect against xenogeneic natural killer cytotoxicity.22881849Abelman M, O'Rourke PP, Sonntag KCThe American journal of bioethics : AJOBPart-human animal research: the imperative to move beyond a philosophical debate. Am J Bioeth. 2012; 12(9):26-8.Am J Bioeth2012-01-01T00:00:002012Part-human animal research: the imperative to move beyond a philosophical debate.