Dr. Grusby's research interests have been on the role of a class of transcription factors called signal transducer and activator of transcription (STATs) in the differentiation and function of T helper cell subsets. Studies from his lab have shown how manipulating STAT activity can alter the function of T helper cells and therefore change the outcome of conditions such as asthma and other inflammatory diseases. In addition, Dr. Grusby has published a number of studies on the biology of the cytokine IL-21, demonstrating its critical role in the development of diabetes. Dr. Grusby served as the past Director of the PhD in Biological Sciences in Public Health (BPH) Program within the Division of Biological Sciences and as a member of the Steering Committee for the Office for Educational Programs.
Professor of Molecular Immunology, Emeritus
Holz A, Bot A, Coon B, Wolfe T, Grusby MJ, von Herrath MG
Journal of immunology (Baltimore, Md. : 1950)
Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence. J Immunol. 1999 Nov 15; 163(10):5374-82.
Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence.
Kaplan MH, Wurster AL, Smiley ST, Grusby MJ
Stat6-dependent and -independent pathways for IL-4 production. J Immunol. 1999 Dec 15; 163(12):6536-40.
Stat6-dependent and -independent pathways for IL-4 production.
Schön MP, Arya A, Murphy EA, Adams CM, Strauch UG, Agace WW, Marsal J, Donohue JP, Her H, Beier DR, Olson S, Lefrancois L, Brenner MB, Grusby MJ, Parker CM
Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice. J Immunol. 1999 Jun 01; 162(11):6641-9.
Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice.
Wurster AL, Withers DJ, Uchida T, White MF, Grusby MJ
Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis. Mol Cell Biol. 2002 Jan; 22(1):117-26.
Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis.
Mombaerts P, Mizoguchi E, Grusby MJ, Glimcher LH, Bhan AK, Tonegawa S
Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell. 1993 Oct 22; 75(2):274-82.
Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice.
Kishimoto K, Dong VM, Issazadeh S, Fedoseyeva EV, Waaga AM, Yamada A, Sho M, Benichou G, Auchincloss H, Grusby MJ, Khoury SJ, Sayegh MH
The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo. J Clin Invest. 2000 Jul; 106(1):63-72.
The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo.
Linette GP, Grusby MJ, Hedrick SM, Hansen TH, Glimcher LH, Korsmeyer SJ
Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity. 1994 Jun; 1(3):197-205.
Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points.
Takahama Y, Suzuki H, Katz KS, Grusby MJ, Singer A
Positive selection of CD4+ T cells by TCR ligation without aggregation even in the absence of MHC. Nature. 1994 Sep 01; 371(6492):67-70.
Positive selection of CD4+ T cells by TCR ligation without aggregation even in the absence of MHC.
Auchincloss H, Lee R, Shea S, Markowitz JS, Grusby MJ, Glimcher LH
Proceedings of the National Academy of Sciences of the United States of America
The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3373-7.
The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice.
Steele DJ, Laufer TM, Smiley ST, Ando Y, Grusby MJ, Glimcher LH, Auchincloss H
Two levels of help for B cell alloantibody production. J Exp Med. 1996 Feb 01; 183(2):699-703.
Two levels of help for B cell alloantibody production.
Suto A, Wurster AL, Reiner SL, Grusby MJ
IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression. J Immunol. 2006 Sep 15; 177(6):3721-7.
IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression.
PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit. Nat Immunol. 2007 Jun; 8(6):584-91.
PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit.
Zheng T, Liu W, Oh SY, Zhu Z, Hu B, Homer RJ, Cohn L, Grusby MJ, Elias JA
IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung. J Immunol. 2008 Jan 01; 180(1):522-9.
IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung.
Hiramatsu Y, Suto A, Kashiwakuma D, Kanari H, Kagami S, Ikeda K, Hirose K, Watanabe N, Grusby MJ, Iwamoto I, Nakajima H
c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-beta inhibits c-Maf-induced IL-21 production in CD4+ T cells. J Leukoc Biol. 2010 Apr; 87(4):703-12.
c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-beta inhibits c-Maf-induced IL-21 production in CD4+ T cells.
Lee RS, Grusby MJ, Glimcher LH, Winn HJ, Auchincloss H
Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo. J Exp Med. 1994 Mar 01; 179(3):865-72.
Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo.
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature. 1996 Jul 11; 382(6587):174-7.
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice.
Tanaka T, Yamamoto Y, Muromoto R, Ikeda O, Sekine Y, Grusby MJ, Kaisho T, Matsuda T
PDLIM2 inhibits T helper 17 cell development and granulomatous inflammation through degradation of STAT3. Sci Signal. 2011 Dec 06; 4(202):ra85.
PDLIM2 inhibits T helper 17 cell development and granulomatous inflammation through degradation of STAT3.
Bream JH, Curiel RE, Yu CR, Egwuagu CE, Grusby MJ, Aune TM, Young HA
IL-4 synergistically enhances both IL-2- and IL-12-induced IFN-gamma expression in murine NK cells. Blood. 2003 Jul 01; 102(1):207-14.
IL-4 synergistically enhances both IL-2- and IL-12-induced IFN-gamma expression in murine NK cells.
Mentink-Kane MM, Cheever AW, Thompson RW, Hari DM, Kabatereine NB, Vennervald BJ, Ouma JH, Mwatha JK, Jones FM, Donaldson DD, Grusby MJ, Dunne DW, Wynn TA
IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):586-90.
IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis.
Nabavi N, Grusby MJ, Finn PW, Wolgemuth DJ, Glimcher LH
Identification of an IL-4-inducible gene expressed in differentiating lymphocytes and male germ cells. Dev Immunol. 1990; 1(1):19-30.
Identification of an IL-4-inducible gene expressed in differentiating lymphocytes and male germ cells.
Effector cells must recognize antigens expressed in the graft to cause efficient skin graft rejection in SCID mice. Transplantation. 1995 Apr 27; 59(8):1223-7.
Effector cells must recognize antigens expressed in the graft to cause efficient skin graft rejection in SCID mice.
Qu Z, Fu J, Ma H, Zhou J, Jin M, Mapara MY, Grusby MJ, Xiao G
PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease. Cell Biosci. 2012 Jun 25; 2(1):23.
PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease.
Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages. J Immunol. 2007 Feb 01; 178(3):1870-81.
Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages.
Laufer TM, von Herrath MG, Grusby MJ, Oldstone MB, Glimcher LH
Autoimmune diabetes can be induced in transgenic major histocompatibility complex class II-deficient mice. J Exp Med. 1993 Aug 01; 178(2):589-96.
Autoimmune diabetes can be induced in transgenic major histocompatibility complex class II-deficient mice.
Markowitz JS, Auchincloss H, Grusby MJ, Glimcher LH
Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice. Proc Natl Acad Sci U S A. 1993 Apr 01; 90(7):2779-83.
Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice.
Smiley ST, Rudensky AY, Glimcher LH, Grusby MJ
Truncation of the class II beta-chain cytoplasmic domain influences the level of class II/invariant chain-derived peptide complexes. Proc Natl Acad Sci U S A. 1996 Jan 09; 93(1):241-4.
Truncation of the class II beta-chain cytoplasmic domain influences the level of class II/invariant chain-derived peptide complexes.
Matsushima GK, Taniike M, Glimcher LH, Grusby MJ, Frelinger JA, Suzuki K, Ting JP
Absence of MHC class II molecules reduces CNS demyelination, microglial/macrophage infiltration, and twitching in murine globoid cell leukodystrophy. Cell. 1994 Aug 26; 78(4):645-56.
Absence of MHC class II molecules reduces CNS demyelination, microglial/macrophage infiltration, and twitching in murine globoid cell leukodystrophy.
Xie Z, Zhang H, Tsai W, Zhang Y, Du Y, Zhong J, Szpirer C, Zhu M, Cao X, Barton MC, Grusby MJ, Zhang WJ
Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. Proc Natl Acad Sci U S A. 2008 Aug 05; 105(31):10859-64.
Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver.
Sutherland AP, Joller N, Michaud M, Liu SM, Kuchroo VK, Grusby MJ
IL-21 promotes CD8+ CTL activity via the transcription factor T-bet. J Immunol. 2013 Apr 15; 190(8):3977-84.
IL-21 promotes CD8+ CTL activity via the transcription factor T-bet.
Crump AL, Grusby MJ, Glimcher LH, Cantor H
Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages. Proc Natl Acad Sci U S A. 1993 Nov 15; 90(22):10739-43.
Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages.
Zhang Y, Xie Z, Zhou L, Li L, Zhang H, Zhou G, Ma X, Herrera PL, Liu Z, Grusby MJ, Zhang WJ
The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and ß cell function in mice. Gastroenterology. 2012 Jun; 142(7):1571-1580.e6.
The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and ß cell function in mice.
Hodge MR, Ranger AM, Charles de la Brousse F, Hoey T, Grusby MJ, Glimcher LH
Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Immunity. 1996 Apr; 4(4):397-405.
Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice.
Cantor H, Crump AL, Raman VK, Liu H, Markowitz JS, Grusby MJ, Glimcher LH
Immunoregulatory effects of superantigens: interactions of staphylococcal enterotoxins with host MHC and non-MHC products. Immunol Rev. 1993 Feb; 131:27-42.
Immunoregulatory effects of superantigens: interactions of staphylococcal enterotoxins with host MHC and non-MHC products.
Suto A, Kashiwakuma D, Kagami S, Hirose K, Watanabe N, Yokote K, Saito Y, Nakayama T, Grusby MJ, Iwamoto I, Nakajima H
Development and characterization of IL-21-producing CD4+ T cells. J Exp Med. 2008 Jun 09; 205(6):1369-79.
Development and characterization of IL-21-producing CD4+ T cells.
Kaplan MH, Daniel C, Schindler U, Grusby MJ
Stat proteins control lymphocyte proliferation by regulating p27Kip1 expression. Mol Cell Biol. 1998 Apr; 18(4):1996-2003.
Stat proteins control lymphocyte proliferation by regulating p27Kip1 expression.
Todd MD, Grusby MJ, Lederer JA, Lacy E, Lichtman AH, Glimcher LH
Transcription of the interleukin 4 gene is regulated by multiple promoter elements. J Exp Med. 1993 Jun 01; 177(6):1663-74.
Transcription of the interleukin 4 gene is regulated by multiple promoter elements.
Eberl G, Lees R, Smiley ST, Taniguchi M, Grusby MJ, MacDonald HR
Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells. J Immunol. 1999 Jun 01; 162(11):6410-9.
Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells.
Lawless VA, Zhang S, Ozes ON, Bruns HA, Oldham I, Hoey T, Grusby MJ, Kaplan MH
Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways. J Immunol. 2000 Dec 15; 165(12):6803-8.
Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways.
Exley MA, Bigley NJ, Cheng O, Tahir SM, Smiley ST, Carter QL, Stills HF, Grusby MJ, Koezuka Y, Taniguchi M, Balk SP
CD1d-reactive T-cell activation leads to amelioration of disease caused by diabetogenic encephalomyocarditis virus. J Leukoc Biol. 2001 May; 69(5):713-8.
CD1d-reactive T-cell activation leads to amelioration of disease caused by diabetogenic encephalomyocarditis virus.
Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher LH
Plasma cell differentiation requires the transcription factor XBP-1. Nature. 2001 Jul 19; 412(6844):300-7.
Plasma cell differentiation requires the transcription factor XBP-1.
Chitnis T, Najafian N, Benou C, Salama AD, Grusby MJ, Sayegh MH, Khoury SJ
Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest. 2001 Sep; 108(5):739-47.
Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis.
Ma HL, Whitters MJ, Konz RF, Senices M, Young DA, Grusby MJ, Collins M, Dunussi-Joannopoulos K
IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma. J Immunol. 2003 Jul 15; 171(2):608-15.
IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma.
SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling. Immunity. 2005 Jun; 22(6):729-36.
SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling.
Reimold AM, Grusby MJ, Kosaras B, Fries JW, Mori R, Maniwa S, Clauss IM, Collins T, Sidman RL, Glimcher MJ, Glimcher LH
Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice. Nature. 1996 Jan 18; 379(6562):262-5.
Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice.
Contribution of IL-12R mediated feedback loop to Th1 cell differentiation. FEBS Lett. 2007 Nov 13; 581(27):5199-206.
Contribution of IL-12R mediated feedback loop to Th1 cell differentiation.
Croy BA, Ashkar AA, Foster RA, DiSanto JP, Magram J, Carson D, Gendler SJ, Grusby MJ, Wagner N, Muller W, Guimond MJ
Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy. J Reprod Immunol. 1997 Nov 15; 35(2):111-33.
Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy.
Lowe ME, Kaplan MH, Jackson-Grusby L, D'Agostino D, Grusby MJ
Decreased neonatal dietary fat absorption and T cell cytotoxicity in pancreatic lipase-related protein 2-deficient mice. J Biol Chem. 1998 Nov 20; 273(47):31215-21.
Decreased neonatal dietary fat absorption and T cell cytotoxicity in pancreatic lipase-related protein 2-deficient mice.
Zhou P, Szot G, Guo Z, Kim O, He G, Wang J, Grusby M, Newell K, Thistlethwaite J, Bluestone J, Alegre M
Role of STAT6 signaling in the induction and long-term maintenance of tolerance mediated by CTLA4-Ig. Transplant Proc. 2001 Feb-Mar; 33(1-2):214-6.
Role of STAT6 signaling in the induction and long-term maintenance of tolerance mediated by CTLA4-Ig.
Wurster AL, Rodgers VL, White MF, Rothstein TL, Grusby MJ
Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL. J Biol Chem. 2002 Jul 26; 277(30):27169-75.
Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL.
Wood N, Whitters MJ, Jacobson BA, Witek J, Sypek JP, Kasaian M, Eppihimer MJ, Unger M, Tanaka T, Goldman SJ, Collins M, Donaldson DD, Grusby MJ
Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2. J Exp Med. 2003 Mar 17; 197(6):703-9.
Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2.
Mehta DS, Wurster AL, Weinmann AS, Grusby MJ
NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression. Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):2016-21.
NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression.
Fathman JW, Gurish MF, Hemmers S, Bonham K, Friend DS, Grusby MJ, Glimcher LH, Mowen KA
NIP45 controls the magnitude of the type 2 T helper cell response. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3663-8.
NIP45 controls the magnitude of the type 2 T helper cell response.
Jelachich ML, Grusby MJ, Clark D, Tasch D, Margoliash E, Pierce SK
Synergistic effects of antigen and soluble T-cell factors in B-lymphocyte activation. Proc Natl Acad Sci U S A. 1984 Sep; 81(17):5537-41.
Synergistic effects of antigen and soluble T-cell factors in B-lymphocyte activation.
Immune responses in MHC class II-deficient mice. Annu Rev Immunol. 1995; 13:417-35.
Immune responses in MHC class II-deficient mice.
Center for Biostatistics in AIDS Research
Harvard T.H. Chan School of Public Health
Richard and Susan Smith Distinguished Professor of Medicine
Samuel L. Wasserstrom Professor of Neurology
Sumner and Esther Feldberg Professor, Emerita
Lajoie S, Lewkowich I, Herman NS, Sproles A, Pesce JT, Wynn TA, Grusby MJ, Hamid Q, Wills-Karp M
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
IL-21 receptor signalling partially mediates Th2-mediated allergic airway responses. Clin Exp Allergy. 2014 Jul; 44(7):976-85.
IL-21 receptor signalling partially mediates Th2-mediated allergic airway responses.
Cao D, Ma X, Cai J, Luan J, Liu AJ, Yang R, Cao Y, Zhu X, Zhang H, Chen YX, Shi Y, Shi GX, Zou D, Cao X, Grusby MJ, Xie Z, Zhang WJ
ZBTB20 is required for anterior pituitary development and lactotrope specification. Nat Commun. 2016 Apr 15; 7:11121.
ZBTB20 is required for anterior pituitary development and lactotrope specification.
MOLECULAR AND GENETIC ANALYSIS OF CTL MEDIATED LYSIS
Regulation of Differentiation &Function of TH2 Cells
Cross-linking of protein S bound to lymphocytes promotes aggregation and inhibits proliferation. Cell Immunol. 1997 Nov 01; 181(2):120-6.
Cross-linking of protein S bound to lymphocytes promotes aggregation and inhibits proliferation.
Daheshia M, Friend DS, Grusby MJ, Austen KF, Katz HR
Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice. J Exp Med. 2001 Jul 16; 194(2):227-34.
Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice.
Wurster AL, Rodgers VL, Satoskar AR, Whitters MJ, Young DA, Collins M, Grusby MJ
Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells. J Exp Med. 2002 Oct 07; 196(7):969-77.
Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells.
Chitnis T, Salama AD, Grusby MJ, Sayegh MH, Khoury SJ
Defining Th1 and Th2 immune responses in a reciprocal cytokine environment in vivo. J Immunol. 2004 Apr 01; 172(7):4260-5.
Defining Th1 and Th2 immune responses in a reciprocal cytokine environment in vivo.
Finn PW, Kara CJ, Grusby MJ, Folsom V, Glimcher LH
Upstream elements of the MHC class II E beta gene active in B cells. J Immunol. 1991 Jun 01; 146(11):4011-5.
Upstream elements of the MHC class II E beta gene active in B cells.
Claesson MH, Bregenholt S, Bonhagen K, Thoma S, Möller P, Grusby MJ, Leithäuser F, Nissen MH, Reimann J
Colitis-inducing potency of CD4+ T cells in immunodeficient, adoptive hosts depends on their state of activation, IL-12 responsiveness, and CD45RB surface phenotype. J Immunol. 1999 Mar 15; 162(6):3702-10.
Colitis-inducing potency of CD4+ T cells in immunodeficient, adoptive hosts depends on their state of activation, IL-12 responsiveness, and CD45RB surface phenotype.
Kim JI, Li T, Ho IC, Grusby MJ, Glimcher LH
Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3781-5.
Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development.
Zhou P, Szot GL, Guo Z, Kim O, He G, Wang J, Grusby MJ, Newell KA, Thistlethwaite JR, Bluestone JA, Alegre ML
Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance. J Immunol. 2000 Nov 15; 165(10):5580-7.
Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.
The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. Immunity. 1999 Jun; 10(6):745-51.
The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines.
Kriebel P, Patel BK, Nelson SA, Grusby MJ, LaRochelle WJ
Consequences of Stat6 deletion on Sis/PDGF- and IL-4-induced proliferation and transcriptional activation in murine fibroblasts. Oncogene. 1999 Dec 02; 18(51):7294-302.
Consequences of Stat6 deletion on Sis/PDGF- and IL-4-induced proliferation and transcriptional activation in murine fibroblasts.
Stat4- and Stat6-deficient mice as models for manipulating T helper cell responses. Biochem Soc Trans. 1997 May; 25(2):359-60.
Stat4- and Stat6-deficient mice as models for manipulating T helper cell responses.
Kaplan MH, Whitfield JR, Boros DL, Grusby MJ
Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response. J Immunol. 1998 Feb 15; 160(4):1850-6.
Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response.
Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells. J Immunol. 1999 May 01; 162(9):5143-8.
Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells.
Jin H, Oyoshi MK, Le Y, Bianchi T, Koduru S, Mathias CB, Kumar L, Le Bras S, Young D, Collins M, Grusby MJ, Wenzel J, Bieber T, Boes M, Silberstein LE, Oettgen HC, Geha RS
IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. J Clin Invest. 2009 Jan; 119(1):47-60.
IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice.
Qu Z, Yan P, Fu J, Jiang J, Grusby MJ, Smithgall TE, Xiao G
DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target. Cancer Res. 2010 Mar 01; 70(5):1766-72.
DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target.
Chiaramonte MG, Mentink-Kane M, Jacobson BA, Cheever AW, Whitters MJ, Goad ME, Wong A, Collins M, Donaldson DD, Grusby MJ, Wynn TA
Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J Exp Med. 2003 Mar 17; 197(6):687-701.
Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response.
Morse HC, McCarty T, Giese NA, Taddesse-Heath L, Grusby MJ
STAT6-deficient mice exhibit normal induction of murine AIDS and expression of immunoglobulin E following infection with LP-BM5 murine leukemia viruses. J Virol. 1999 Aug; 73(8):7093-5.
STAT6-deficient mice exhibit normal induction of murine AIDS and expression of immunoglobulin E following infection with LP-BM5 murine leukemia viruses.
Reimold AM, Etkin A, Clauss I, Perkins A, Friend DS, Zhang J, Horton HF, Scott A, Orkin SH, Byrne MC, Grusby MJ, Glimcher LH
An essential role in liver development for transcription factor XBP-1. Genes Dev. 2000 Jan 15; 14(2):152-7.
An essential role in liver development for transcription factor XBP-1.
Kasaian MT, Whitters MJ, Carter LL, Lowe LD, Jussif JM, Deng B, Johnson KA, Witek JS, Senices M, Konz RF, Wurster AL, Donaldson DD, Collins M, Young DA, Grusby MJ
IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity. 2002 Apr; 16(4):559-69.
IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity.
Pesce J, Kaviratne M, Ramalingam TR, Thompson RW, Urban JF, Cheever AW, Young DA, Collins M, Grusby MJ, Wynn TA
The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J Clin Invest. 2006 Jul; 116(7):2044-55.
The IL-21 receptor augments Th2 effector function and alternative macrophage activation.
Schofield L, McConville MJ, Hansen D, Campbell AS, Fraser-Reid B, Grusby MJ, Tachado SD
CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells. Science. 1999 Jan 08; 283(5399):225-9.
CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells.
Ong CJ, Ip S, Teh SJ, Wong C, Jirik FR, Grusby MJ, Teh HS
A role for T helper 2 cells in mediating skin fibrosis in tight-skin mice. Cell Immunol. 1999 Aug 25; 196(1):60-8.
A role for T helper 2 cells in mediating skin fibrosis in tight-skin mice.
Shimamura M, Huang YY, Suda Y, Kusumoto S, Sato K, Grusby MJ, Sato H, Nakayama T, Taniguchi M
Positive selection of NKT cells by CD1(+), CD11c(+) non-lymphoid cells residing in the extrathymic organs. Eur J Immunol. 1999 12; 29(12):3962-70.
Positive selection of NKT cells by CD1(+), CD11c(+) non-lymphoid cells residing in the extrathymic organs.
Dual-receptor T cells expressing one self-restricted TCR. Scand J Immunol. 1997 Jun; 45(6):726-30.
Dual-receptor T cells expressing one self-restricted TCR.
Ranger AM, Hodge MR, Gravallese EM, Oukka M, Davidson L, Alt FW, de la Brousse FC, Hoey T, Grusby M, Glimcher LH
Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity. 1998 Jan; 8(1):125-34.
Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc.
Kuperman D, Schofield B, Wills-Karp M, Grusby MJ
Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J Exp Med. 1998 Mar 16; 187(6):939-48.
Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production.
Ostrand-Rosenberg S, Grusby MJ, Clements VK
Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma. J Immunol. 2000 Dec 01; 165(11):6015-9.
Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma.
Chung DR, Kasper DL, Panzo RJ, Chitnis T, Grusby MJ, Sayegh MH, Tzianabos AO, Chtinis T
CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism. J Immunol. 2003 Feb 15; 170(4):1958-63.
CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism.
Genomic organization of the murine CTL lipase gene. Genomics. 1996 Aug 01; 35(3):606-9.
Genomic organization of the murine CTL lipase gene.
The biology of Stat4 and Stat6. Oncogene. 2000 May 15; 19(21):2577-84.
Liu Q, Arseculeratne C, Liu Z, Whitmire J, Grusby MJ, Finkelman FD, Darling TN, Cheever AW, Swearengen J, Urban JF, Gause WC
Simultaneous deficiency in CD28 and STAT6 results in chronic ectoparasite-induced inflammatory skin disease. Infect Immun. 2004 Jul; 72(7):3706-15.
Simultaneous deficiency in CD28 and STAT6 results in chronic ectoparasite-induced inflammatory skin disease.
Herold KC, Lu J, Rulifson I, Vezys V, Taub D, Grusby MJ, Bluestone JA
Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation. J Immunol. 1997 Nov 01; 159(9):4150-3.
Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation.
Oukka M, Ho IC, de la Brousse FC, Hoey T, Grusby MJ, Glimcher LH
The transcription factor NFAT4 is involved in the generation and survival of T cells. Immunity. 1998 Sep; 9(3):295-304.
The transcription factor NFAT4 is involved in the generation and survival of T cells.
Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science. 1997 Feb 14; 275(5302):977-9.
Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells.
Sendobry SM, Cornicelli JA, Welch K, Grusby MJ, Daugherty A
Absence of T lymphocyte-derived cytokines fails to diminish macrophage 12/15-lipoxygenase expression in vivo. J Immunol. 1998 Aug 01; 161(3):1477-82.
Absence of T lymphocyte-derived cytokines fails to diminish macrophage 12/15-lipoxygenase expression in vivo.
Burdin N, Brossay L, Koezuka Y, Smiley ST, Grusby MJ, Gui M, Taniguchi M, Hayakawa K, Kronenberg M
Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes. J Immunol. 1998 Oct 01; 161(7):3271-81.
Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes.
Finnegan A, Grusby MJ, Kaplan CD, O'Neill SK, Eibel H, Koreny T, Czipri M, Mikecz K, Zhang J
IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms. J Immunol. 2002 Sep 15; 169(6):3345-52.
IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms.
Nikolic B, Lee S, Bronson RT, Grusby MJ, Sykes M
Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets. J Clin Invest. 2000 May; 105(9):1289-98.
Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets.
Yan P, Fu J, Qu Z, Li S, Tanaka T, Grusby MJ, Xiao G
PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation. Blood. 2009 Apr 30; 113(18):4370-80.
PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation.
Keane MP, Gomperts BN, Weigt S, Xue YY, Burdick MD, Nakamura H, Zisman DA, Ardehali A, Saggar R, Lynch JP, Hogaboam C, Kunkel SL, Lukacs NW, Ross DJ, Grusby MJ, Strieter RM, Belperio JA
IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome. J Immunol. 2007 Jan 01; 178(1):511-9.
IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome.
Lim YC, Xie H, Come CE, Alexander SI, Grusby MJ, Lichtman AH, Luscinskas FW
IL-12, STAT4-dependent up-regulation of CD4(+) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands. J Immunol. 2001 Oct 15; 167(8):4476-84.
IL-12, STAT4-dependent up-regulation of CD4(+) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands.
Eyles JL, Metcalf D, Grusby MJ, Hilton DJ, Starr R
Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1. J Biol Chem. 2002 Nov 15; 277(46):43735-40.
Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1.
Grusby MJ, Nabavi N, Wong H, Dick RF, Bluestone JA, Schotz MC, Glimcher LH
Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase. Cell. 1990 Feb 09; 60(3):451-9.
Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase.
Nakahira M, Tanaka T, Robson BE, Mizgerd JP, Grusby MJ
Regulation of signal transducer and activator of transcription signaling by the tyrosine phosphatase PTP-BL. Immunity. 2007 Feb; 26(2):163-76.
Regulation of signal transducer and activator of transcription signaling by the tyrosine phosphatase PTP-BL.
Regulation of T helper cell differentiation by STAT molecules. J Leukoc Biol. 1998 Jul; 64(1):2-5.
Regulation of T helper cell differentiation by STAT molecules.
Behar SM, Dascher CC, Grusby MJ, Wang CR, Brenner MB
Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis. J Exp Med. 1999 Jun 21; 189(12):1973-80.
Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis.
Wild J, Grusby MJ, Schirmbeck R, Reimann J
Priming MHC-I-restricted cytotoxic T lymphocyte responses to exogenous hepatitis B surface antigen is CD4+ T cell dependent. J Immunol. 1999 Aug 15; 163(4):1880-7.
Priming MHC-I-restricted cytotoxic T lymphocyte responses to exogenous hepatitis B surface antigen is CD4+ T cell dependent.
Mehta DS, Wurster AL, Whitters MJ, Young DA, Collins M, Grusby MJ
IL-21 induces the apoptosis of resting and activated primary B cells. J Immunol. 2003 Apr 15; 170(8):4111-8.
IL-21 induces the apoptosis of resting and activated primary B cells.
Pierce SK, Morris JF, Grusby MJ, Kaumaya P, van Buskirk A, Srinivasan M, Crump B, Smolenski LA
Antigen-presenting function of B lymphocytes. Immunol Rev. 1988 Dec; 106:149-80.
Antigen-presenting function of B lymphocytes.
Grusby MJ, Auchincloss H, Lee R, Johnson RS, Spencer JP, Zijlstra M, Jaenisch R, Papaioannou VE, Glimcher LH
Mice lacking major histocompatibility complex class I and class II molecules. Proc Natl Acad Sci U S A. 1993 May 01; 90(9):3913-7.
Mice lacking major histocompatibility complex class I and class II molecules.
Tarleton RL, Grusby MJ, Postan M, Glimcher LH
Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease. Int Immunol. 1996 Jan; 8(1):13-22.
Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease.
Biology of IL-21 and the IL-21 receptor. Immunol Rev. 2004 Dec; 202:84-95.
Biology of IL-21 and the IL-21 receptor.
Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi. J Immunol. 2000 Aug 01; 165(3):1520-5.
Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi.
Grusby MJ, Mitchell SC, Nabavi N, Glimcher LH
Casein expression in cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 1990 Sep; 87(17):6897-901.
Casein expression in cytotoxic T lymphocytes.
Sutherland AP, Van Belle T, Wurster AL, Suto A, Michaud M, Zhang D, Grusby MJ, von Herrath M
Interleukin-21 is required for the development of type 1 diabetes in NOD mice. Diabetes. 2009 May; 58(5):1144-55.
Interleukin-21 is required for the development of type 1 diabetes in NOD mice.
Induction of antigen-specific antibody responses by nonspecific T cell-derived helper factors. Immunol Res. 1986; 5(3):201-9.
Induction of antigen-specific antibody responses by nonspecific T cell-derived helper factors.
Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice. J Exp Med. 1994 Apr 01; 179(4):1137-43.
Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice.
Kaplan MH, Schindler U, Smiley ST, Grusby MJ
Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity. 1996 Mar; 4(3):313-9.
Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.
Linehan LA, Warren WD, Thompson PA, Grusby MJ, Berton MT
STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination. J Immunol. 1998 Jul 01; 161(1):302-10.
STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination.
STATs as mediators of cytokine-induced responses. Adv Immunol. 1999; 71:145-62.
STATs as mediators of cytokine-induced responses.
Chakkalath HR, Theodos CM, Markowitz JS, Grusby MJ, Glimcher LH, Titus RG
Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the disease. J Infect Dis. 1995 May; 171(5):1302-8.
Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the disease.
Homann D, Holz A, Bot A, Coon B, Wolfe T, Petersen J, Dyrberg TP, Grusby MJ, von Herrath MG
Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway. Immunity. 1999 Oct; 11(4):463-72.
Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway.
Grusby MJ, Johnson RS, Papaioannou VE, Glimcher LH
Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice. Science. 1991 Sep 20; 253(5026):1417-20.
Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice.
Molecular cloning of mouse cathepsin D. Nucleic Acids Res. 1990 Jul 11; 18(13):4008.
Satake Y, Diaz BL, Balestrieri B, Lam BK, Kanaoka Y, Grusby MJ, Arm JP
Role of group V phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption. J Biol Chem. 2004 Apr 16; 279(16):16488-94.
Role of group V phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption.
Markowitz JS, Rogers PR, Grusby MJ, Parker DC, Glimcher LH
B lymphocyte development and activation independent of MHC class II expression. J Immunol. 1993 Feb 15; 150(4):1223-33.
B lymphocyte development and activation independent of MHC class II expression.
Avery AC, Markowitz JS, Grusby MJ, Glimcher LH, Cantor H
Activation of T cells by superantigen in class II-negative mice. J Immunol. 1994 Dec 01; 153(11):4853-61.
Activation of T cells by superantigen in class II-negative mice.
Mombaerts P, Mizoguchi E, Ljunggren HG, Iacomini J, Ishikawa H, Wang L, Grusby MJ, Glimcher LH, Winn HJ, Bhan AK
Peripheral lymphoid development and function in TCR mutant mice. Int Immunol. 1994 Jul; 6(7):1061-70.
Peripheral lymphoid development and function in TCR mutant mice.
Bigby M, Markowitz JS, Bleicher PA, Grusby MJ, Simha S, Siebrecht M, Wagner M, Nagler-Anderson C, Glimcher LH
Most gamma delta T cells develop normally in the absence of MHC class II molecules. J Immunol. 1993 Nov 01; 151(9):4465-75.
Most gamma delta T cells develop normally in the absence of MHC class II molecules.
Touma M, Antonini V, Kumar M, Osborn SL, Bobenchik AM, Keskin DB, Connolly JE, Grusby MJ, Reinherz EL, Clayton LK
Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption. J Immunol. 2007 Aug 01; 179(3):1681-92.
Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption.
Smiley ST, Laufer TM, Lo D, Glimcher LH, Grusby MJ
Transgenic mice expressing MHC class II molecules with truncated A beta cytoplasmic domains reveal signaling-independent defects in antigen presentation. Int Immunol. 1995 Apr; 7(4):665-77.
Transgenic mice expressing MHC class II molecules with truncated A beta cytoplasmic domains reveal signaling-independent defects in antigen presentation.
Identification of the small protein rich in arginine and glycine (SRAG): a newly identified nucleolar protein that can regulate cell proliferation. J Biol Chem. 2009 May 01; 284(18):12504-11.
Identification of the small protein rich in arginine and glycine (SRAG): a newly identified nucleolar protein that can regulate cell proliferation.
Sutherland AP, Zhang H, Zhang Y, Michaud M, Xie Z, Patti ME, Grusby MJ, Zhang WJ
Zinc finger protein Zbtb20 is essential for postnatal survival and glucose homeostasis. Mol Cell Biol. 2009 May; 29(10):2804-15.
Zinc finger protein Zbtb20 is essential for postnatal survival and glucose homeostasis.
A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells. J Exp Med. 1998 Sep 21; 188(6):1191-6.
A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells.
Ranger AM, Grusby MJ, Hodge MR, Gravallese EM, de la Brousse FC, Hoey T, Mickanin C, Baldwin HS, Glimcher LH
The transcription factor NF-ATc is essential for cardiac valve formation. Nature. 1998 Mar 12; 392(6672):186-90.
The transcription factor NF-ATc is essential for cardiac valve formation.
Lee RS, Grusby MJ, Laufer TM, Colvin R, Glimcher LH, Auchincloss H
CD8+ effector cells responding to residual class I antigens, with help from CD4+ cells stimulated indirectly, cause rejection of "major histocompatibility complex-deficient" skin grafts. Transplantation. 1997 Apr 27; 63(8):1123-33.
CD8+ effector cells responding to residual class I antigens, with help from CD4+ cells stimulated indirectly, cause rejection of "major histocompatibility complex-deficient" skin grafts.
Smiley ST, Boyer SN, Heeb MJ, Griffin JH, Grusby MJ
Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11484-9.
Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity.
Huang H, Kearney JF, Grusby MJ, Benoist C, Mathis D
Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen. Proc Natl Acad Sci U S A. 2006 Mar 07; 103(10):3734-9.
Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen.
Ho IC, Kaplan MH, Jackson-Grusby L, Glimcher LH, Grusby MJ
Marking IL-4-producing cells by knock-in of the IL-4 gene. Int Immunol. 1999 Feb; 11(2):243-7.
Marking IL-4-producing cells by knock-in of the IL-4 gene.
Akbari O, Stock P, Meyer E, Kronenberg M, Sidobre S, Nakayama T, Taniguchi M, Grusby MJ, DeKruyff RH, Umetsu DT
Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med. 2003 May; 9(5):582-8.
Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity.