Grusby, Michael
eCommons Login: MJG6
first name: Michael
last name: Grusby
coauthor of: Glimcher, Laurie
coauthor of: Auchincloss, Hugh
coauthor of: Ho, I-Cheng
coauthor of: Chitnis, Tanuja
coauthor of: Khoury, Samia
full name: Michael Grusby, Ph.D.
has faculty rank: Full Professor
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latitude: 42.33517680000000
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photo: https://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 20188
person in primary position: Professor of Molecular Immunology, Emeritus
physical neighbor: Adami, Hans-Olov
physical neighbor: Hernandez-Diaz, Sonia
physical neighbor: McCormick, Marie
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similar to: Kuchroo, Vijay
similar to: Geha, Raif
similar to: Glimcher, Laurie
similar to: Colonna, Marco
similar to: Tsokos, George
type: Agent
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selected publications: Authorship 876804
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Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence.
PubMed Identifier: 10553062
author list: Holz A, Bot A, Coon B, Wolfe T, Grusby MJ, von Herrath MG
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence. J Immunol. 1999 Nov 15; 163(10):5374-82.
journal title abbreviation: J Immunol
publication date: 1999-11-15T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Stat6-dependent and -independent pathways for IL-4 production.
PubMed Identifier: 10586046
author list: Kaplan MH, Wurster AL, Smiley ST, Grusby MJ
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Stat6-dependent and -independent pathways for IL-4 production. J Immunol. 1999 Dec 15; 163(12):6536-40.
journal title abbreviation: J Immunol
publication date: 1999-12-15T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice.
PubMed Identifier: 10352281
author list: Schön MP, Arya A, Murphy EA, Adams CM, Strauch UG, Agace WW, Marsal J, Donohue JP, Her H, Beier DR, Olson S, Lefrancois L, Brenner MB, Grusby MJ, Parker CM
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice. J Immunol. 1999 Jun 01; 162(11):6641-9.
journal title abbreviation: J Immunol
publication date: 1999-06-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis.
PubMed Identifier: 11739727
author list: Wurster AL, Withers DJ, Uchida T, White MF, Grusby MJ
published in: Molecular and cellular biology
information resource reference: Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis. Mol Cell Biol. 2002 Jan; 22(1):117-26.
journal title abbreviation: Mol Cell Biol
publication date: 2002-01-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice.
PubMed Identifier: 8104709
author list: Mombaerts P, Mizoguchi E, Grusby MJ, Glimcher LH, Bhan AK, Tonegawa S
published in: Cell
information resource reference: Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell. 1993 Oct 22; 75(2):274-82.
journal title abbreviation: Cell
publication date: 1993-10-22T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo.
PubMed Identifier: 10880049
author list: Kishimoto K, Dong VM, Issazadeh S, Fedoseyeva EV, Waaga AM, Yamada A, Sho M, Benichou G, Auchincloss H, Grusby MJ, Khoury SJ, Sayegh MH
published in: The Journal of clinical investigation
information resource reference: The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo. J Clin Invest. 2000 Jul; 106(1):63-72.
journal title abbreviation: J Clin Invest
publication date: 2000-07-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points.
PubMed Identifier: 7889408
author list: Linette GP, Grusby MJ, Hedrick SM, Hansen TH, Glimcher LH, Korsmeyer SJ
published in: Immunity
information resource reference: Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity. 1994 Jun; 1(3):197-205.
journal title abbreviation: Immunity
publication date: 1994-06-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Positive selection of CD4+ T cells by TCR ligation without aggregation even in the absence of MHC.
PubMed Identifier: 7915400
author list: Takahama Y, Suzuki H, Katz KS, Grusby MJ, Singer A
published in: Nature
information resource reference: Positive selection of CD4+ T cells by TCR ligation without aggregation even in the absence of MHC. Nature. 1994 Sep 01; 371(6492):67-70.
journal title abbreviation: Nature
publication date: 1994-09-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice.
PubMed Identifier: 8475083
author list: Auchincloss H, Lee R, Shea S, Markowitz JS, Grusby MJ, Glimcher LH
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3373-7.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1993-04-15T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Two levels of help for B cell alloantibody production.
PubMed Identifier: 8627185
author list: Steele DJ, Laufer TM, Smiley ST, Ando Y, Grusby MJ, Glimcher LH, Auchincloss H
published in: The Journal of experimental medicine
information resource reference: Two levels of help for B cell alloantibody production. J Exp Med. 1996 Feb 01; 183(2):699-703.
journal title abbreviation: J Exp Med
publication date: 1996-02-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression.
PubMed Identifier: 16951332
author list: Suto A, Wurster AL, Reiner SL, Grusby MJ
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression. J Immunol. 2006 Sep 15; 177(6):3721-7.
journal title abbreviation: J Immunol
publication date: 2006-09-15T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit.
PubMed Identifier: 17468759
author list: Tanaka T, Grusby MJ, Kaisho T
published in: Nature immunology
information resource reference: PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit. Nat Immunol. 2007 Jun; 8(6):584-91.
journal title abbreviation: Nat Immunol
publication date: 2007-04-29T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 107035
type: Authorship
author rank in publication: 5
linked author: Grusby, Michael
linked information resource: The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice.

IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung.
PubMed Identifier: 18097054
author list: Zheng T, Liu W, Oh SY, Zhu Z, Hu B, Homer RJ, Cohn L, Grusby MJ, Elias JA
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung. J Immunol. 2008 Jan 01; 180(1):522-9.
journal title abbreviation: J Immunol
publication date: 2008-01-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-beta inhibits c-Maf-induced IL-21 production in CD4+ T cells.
PubMed Identifier: 20042469
author list: Hiramatsu Y, Suto A, Kashiwakuma D, Kanari H, Kagami S, Ikeda K, Hirose K, Watanabe N, Grusby MJ, Iwamoto I, Nakajima H
published in: Journal of leukocyte biology
information resource reference: c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-beta inhibits c-Maf-induced IL-21 production in CD4+ T cells. J Leukoc Biol. 2010 Apr; 87(4):703-12.
journal title abbreviation: J Leukoc Biol
publication date: 2009-12-30T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo.
PubMed Identifier: 8113680
author list: Lee RS, Grusby MJ, Glimcher LH, Winn HJ, Auchincloss H
published in: The Journal of experimental medicine
information resource reference: Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo. J Exp Med. 1994 Mar 01; 179(3):865-72.
journal title abbreviation: J Exp Med
publication date: 1994-03-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice.
PubMed Identifier: 8700209
author list: Kaplan MH, Sun YL, Hoey T, Grusby MJ
published in: Nature
information resource reference: Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature. 1996 Jul 11; 382(6587):174-7.
journal title abbreviation: Nature
publication date: 1996-07-11T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 107848
type: Authorship
author rank in publication: 6
linked author: Grusby, Michael
linked information resource: Role of group V phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption.

PDLIM2 inhibits T helper 17 cell development and granulomatous inflammation through degradation of STAT3.
PubMed Identifier: 22155789
author list: Tanaka T, Yamamoto Y, Muromoto R, Ikeda O, Sekine Y, Grusby MJ, Kaisho T, Matsuda T
published in: Science signaling
information resource reference: PDLIM2 inhibits T helper 17 cell development and granulomatous inflammation through degradation of STAT3. Sci Signal. 2011 Dec 06; 4(202):ra85.
journal title abbreviation: Sci Signal
publication date: 2011-12-06T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

IL-4 synergistically enhances both IL-2- and IL-12-induced IFN-gamma expression in murine NK cells.
PubMed Identifier: 12637316
author list: Bream JH, Curiel RE, Yu CR, Egwuagu CE, Grusby MJ, Aune TM, Young HA
published in: Blood
information resource reference: IL-4 synergistically enhances both IL-2- and IL-12-induced IFN-gamma expression in murine NK cells. Blood. 2003 Jul 01; 102(1):207-14.
journal title abbreviation: Blood
publication date: 2003-03-13T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis.
PubMed Identifier: 14699044
author list: Mentink-Kane MM, Cheever AW, Thompson RW, Hari DM, Kabatereine NB, Vennervald BJ, Ouma JH, Mwatha JK, Jones FM, Donaldson DD, Grusby MJ, Dunne DW, Wynn TA
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis. Proc Natl Acad Sci U S A. 2004 Jan 13; 101(2):586-90.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2003-12-29T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of an IL-4-inducible gene expressed in differentiating lymphocytes and male germ cells.
PubMed Identifier: 2136202
author list: Nabavi N, Grusby MJ, Finn PW, Wolgemuth DJ, Glimcher LH
published in: Developmental immunology
information resource reference: Identification of an IL-4-inducible gene expressed in differentiating lymphocytes and male germ cells. Dev Immunol. 1990; 1(1):19-30.
journal title abbreviation: Dev Immunol
publication date: 1990-01-01T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Effector cells must recognize antigens expressed in the graft to cause efficient skin graft rejection in SCID mice.
PubMed Identifier: 7732570
author list: Wecker H, Grusby MJ, Auchincloss H
published in: Transplantation
information resource reference: Effector cells must recognize antigens expressed in the graft to cause efficient skin graft rejection in SCID mice. Transplantation. 1995 Apr 27; 59(8):1223-7.
journal title abbreviation: Transplantation
publication date: 1995-04-27T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease.
PubMed Identifier: 22731402
author list: Qu Z, Fu J, Ma H, Zhou J, Jin M, Mapara MY, Grusby MJ, Xiao G
published in: Cell & bioscience
information resource reference: PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease. Cell Biosci. 2012 Jun 25; 2(1):23.
journal title abbreviation: Cell Biosci
publication date: 2012-06-25T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages.
PubMed Identifier: 17237438
author list: Gao C, Guo H, Mi Z, Grusby MJ, Kuo PC
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages. J Immunol. 2007 Feb 01; 178(3):1870-81.
journal title abbreviation: J Immunol
publication date: 2007-02-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1222
type: Authorship
author rank in publication: 11
linked author: Grusby, Michael
linked information resource: IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice.

Autoimmune diabetes can be induced in transgenic major histocompatibility complex class II-deficient mice.
PubMed Identifier: 8101862
author list: Laufer TM, von Herrath MG, Grusby MJ, Oldstone MB, Glimcher LH
published in: The Journal of experimental medicine
information resource reference: Autoimmune diabetes can be induced in transgenic major histocompatibility complex class II-deficient mice. J Exp Med. 1993 Aug 01; 178(2):589-96.
journal title abbreviation: J Exp Med
publication date: 1993-08-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice.
PubMed Identifier: 8464889
author list: Markowitz JS, Auchincloss H, Grusby MJ, Glimcher LH
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice. Proc Natl Acad Sci U S A. 1993 Apr 01; 90(7):2779-83.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1993-04-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Truncation of the class II beta-chain cytoplasmic domain influences the level of class II/invariant chain-derived peptide complexes.
PubMed Identifier: 8552613
author list: Smiley ST, Rudensky AY, Glimcher LH, Grusby MJ
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Truncation of the class II beta-chain cytoplasmic domain influences the level of class II/invariant chain-derived peptide complexes. Proc Natl Acad Sci U S A. 1996 Jan 09; 93(1):241-4.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1996-01-09T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Absence of MHC class II molecules reduces CNS demyelination, microglial/macrophage infiltration, and twitching in murine globoid cell leukodystrophy.
PubMed Identifier: 8069913
author list: Matsushima GK, Taniike M, Glimcher LH, Grusby MJ, Frelinger JA, Suzuki K, Ting JP
published in: Cell
information resource reference: Absence of MHC class II molecules reduces CNS demyelination, microglial/macrophage infiltration, and twitching in murine globoid cell leukodystrophy. Cell. 1994 Aug 26; 78(4):645-56.
journal title abbreviation: Cell
publication date: 1994-08-26T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver.
PubMed Identifier: 18669658
author list: Xie Z, Zhang H, Tsai W, Zhang Y, Du Y, Zhong J, Szpirer C, Zhu M, Cao X, Barton MC, Grusby MJ, Zhang WJ
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. Proc Natl Acad Sci U S A. 2008 Aug 05; 105(31):10859-64.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2008-07-31T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

IL-21 promotes CD8+ CTL activity via the transcription factor T-bet.
PubMed Identifier: 23479229
author list: Sutherland AP, Joller N, Michaud M, Liu SM, Kuchroo VK, Grusby MJ
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: IL-21 promotes CD8+ CTL activity via the transcription factor T-bet. J Immunol. 2013 Apr 15; 190(8):3977-84.
journal title abbreviation: J Immunol
publication date: 2013-03-11T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages.
PubMed Identifier: 7902569
author list: Crump AL, Grusby MJ, Glimcher LH, Cantor H
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages. Proc Natl Acad Sci U S A. 1993 Nov 15; 90(22):10739-43.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1993-11-15T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and ß cell function in mice.
PubMed Identifier: 22374165
author list: Zhang Y, Xie Z, Zhou L, Li L, Zhang H, Zhou G, Ma X, Herrera PL, Liu Z, Grusby MJ, Zhang WJ
published in: Gastroenterology
information resource reference: The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and ß cell function in mice. Gastroenterology. 2012 Jun; 142(7):1571-1580.e6.
journal title abbreviation: Gastroenterology
publication date: 2012-02-25T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice.
PubMed Identifier: 8612134
author list: Hodge MR, Ranger AM, Charles de la Brousse F, Hoey T, Grusby MJ, Glimcher LH
published in: Immunity
information resource reference: Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Immunity. 1996 Apr; 4(4):397-405.
journal title abbreviation: Immunity
publication date: 1996-04-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Immunoregulatory effects of superantigens: interactions of staphylococcal enterotoxins with host MHC and non-MHC products.
PubMed Identifier: 8486393
author list: Cantor H, Crump AL, Raman VK, Liu H, Markowitz JS, Grusby MJ, Glimcher LH
published in: Immunological reviews
information resource reference: Immunoregulatory effects of superantigens: interactions of staphylococcal enterotoxins with host MHC and non-MHC products. Immunol Rev. 1993 Feb; 131:27-42.
journal title abbreviation: Immunol Rev
publication date: 1993-02-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Development and characterization of IL-21-producing CD4+ T cells.
PubMed Identifier: 18474630
author list: Suto A, Kashiwakuma D, Kagami S, Hirose K, Watanabe N, Yokote K, Saito Y, Nakayama T, Grusby MJ, Iwamoto I, Nakajima H
published in: The Journal of experimental medicine
information resource reference: Development and characterization of IL-21-producing CD4+ T cells. J Exp Med. 2008 Jun 09; 205(6):1369-79.
journal title abbreviation: J Exp Med
publication date: 2008-05-12T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Stat proteins control lymphocyte proliferation by regulating p27Kip1 expression.
PubMed Identifier: 9528771
author list: Kaplan MH, Daniel C, Schindler U, Grusby MJ
published in: Molecular and cellular biology
information resource reference: Stat proteins control lymphocyte proliferation by regulating p27Kip1 expression. Mol Cell Biol. 1998 Apr; 18(4):1996-2003.
journal title abbreviation: Mol Cell Biol
publication date: 1998-04-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Transcription of the interleukin 4 gene is regulated by multiple promoter elements.
PubMed Identifier: 8496684
author list: Todd MD, Grusby MJ, Lederer JA, Lacy E, Lichtman AH, Glimcher LH
published in: The Journal of experimental medicine
information resource reference: Transcription of the interleukin 4 gene is regulated by multiple promoter elements. J Exp Med. 1993 Jun 01; 177(6):1663-74.
journal title abbreviation: J Exp Med
publication date: 1993-06-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells.
PubMed Identifier: 10352254
author list: Eberl G, Lees R, Smiley ST, Taniguchi M, Grusby MJ, MacDonald HR
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells. J Immunol. 1999 Jun 01; 162(11):6410-9.
journal title abbreviation: J Immunol
publication date: 1999-06-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways.
PubMed Identifier: 11120802
author list: Lawless VA, Zhang S, Ozes ON, Bruns HA, Oldham I, Hoey T, Grusby MJ, Kaplan MH
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways. J Immunol. 2000 Dec 15; 165(12):6803-8.
journal title abbreviation: J Immunol
publication date: 2000-12-15T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

CD1d-reactive T-cell activation leads to amelioration of disease caused by diabetogenic encephalomyocarditis virus.
PubMed Identifier: 11358978
author list: Exley MA, Bigley NJ, Cheng O, Tahir SM, Smiley ST, Carter QL, Stills HF, Grusby MJ, Koezuka Y, Taniguchi M, Balk SP
published in: Journal of leukocyte biology
information resource reference: CD1d-reactive T-cell activation leads to amelioration of disease caused by diabetogenic encephalomyocarditis virus. J Leukoc Biol. 2001 May; 69(5):713-8.
journal title abbreviation: J Leukoc Biol
publication date: 2001-05-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Plasma cell differentiation requires the transcription factor XBP-1.
PubMed Identifier: 11460154
author list: Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher LH
published in: Nature
information resource reference: Plasma cell differentiation requires the transcription factor XBP-1. Nature. 2001 Jul 19; 412(6844):300-7.
journal title abbreviation: Nature
publication date: 2001-07-19T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis.
PubMed Identifier: 11544280
author list: Chitnis T, Najafian N, Benou C, Salama AD, Grusby MJ, Sayegh MH, Khoury SJ
published in: The Journal of clinical investigation
information resource reference: Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest. 2001 Sep; 108(5):739-47.
journal title abbreviation: J Clin Invest
publication date: 2001-09-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma.
PubMed Identifier: 12847225
author list: Ma HL, Whitters MJ, Konz RF, Senices M, Young DA, Grusby MJ, Collins M, Dunussi-Joannopoulos K
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma. J Immunol. 2003 Jul 15; 171(2):608-15.
journal title abbreviation: J Immunol
publication date: 2003-07-15T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling.
PubMed Identifier: 15963787
author list: Tanaka T, Soriano MA, Grusby MJ
published in: Immunity
information resource reference: SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling. Immunity. 2005 Jun; 22(6):729-36.
journal title abbreviation: Immunity
publication date: 2005-06-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice.
PubMed Identifier: 8538792
author list: Reimold AM, Grusby MJ, Kosaras B, Fries JW, Mori R, Maniwa S, Clauss IM, Collins T, Sidman RL, Glimcher MJ, Glimcher LH
published in: Nature
information resource reference: Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice. Nature. 1996 Jan 18; 379(6562):262-5.
journal title abbreviation: Nature
publication date: 1996-01-18T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Contribution of IL-12R mediated feedback loop to Th1 cell differentiation.
PubMed Identifier: 17950290
author list: Becskei A, Grusby MJ
published in: FEBS letters
information resource reference: Contribution of IL-12R mediated feedback loop to Th1 cell differentiation. FEBS Lett. 2007 Nov 13; 581(27):5199-206.
journal title abbreviation: FEBS Lett
publication date: 2007-10-12T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 119562
type: Authorship
author rank in publication: 11
linked author: Grusby, Michael
linked information resource: IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis.

Authorship 113885
type: Authorship
author rank in publication: 2
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linked information resource: Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice.

Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy.
PubMed Identifier: 9421796
author list: Croy BA, Ashkar AA, Foster RA, DiSanto JP, Magram J, Carson D, Gendler SJ, Grusby MJ, Wagner N, Muller W, Guimond MJ
published in: Journal of reproductive immunology
information resource reference: Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy. J Reprod Immunol. 1997 Nov 15; 35(2):111-33.
journal title abbreviation: J Reprod Immunol
publication date: 1997-11-15T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Decreased neonatal dietary fat absorption and T cell cytotoxicity in pancreatic lipase-related protein 2-deficient mice.
PubMed Identifier: 9813028
author list: Lowe ME, Kaplan MH, Jackson-Grusby L, D'Agostino D, Grusby MJ
published in: The Journal of biological chemistry
information resource reference: Decreased neonatal dietary fat absorption and T cell cytotoxicity in pancreatic lipase-related protein 2-deficient mice. J Biol Chem. 1998 Nov 20; 273(47):31215-21.
journal title abbreviation: J Biol Chem
publication date: 1998-11-20T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Role of STAT6 signaling in the induction and long-term maintenance of tolerance mediated by CTLA4-Ig.
PubMed Identifier: 11266784
author list: Zhou P, Szot G, Guo Z, Kim O, He G, Wang J, Grusby M, Newell K, Thistlethwaite J, Bluestone J, Alegre M
published in: Transplantation proceedings
information resource reference: Role of STAT6 signaling in the induction and long-term maintenance of tolerance mediated by CTLA4-Ig. Transplant Proc. 2001 Feb-Mar; 33(1-2):214-6.
journal title abbreviation: Transplant Proc
publication date: 2001-02-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL.
PubMed Identifier: 12023955
author list: Wurster AL, Rodgers VL, White MF, Rothstein TL, Grusby MJ
published in: The Journal of biological chemistry
information resource reference: Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL. J Biol Chem. 2002 Jul 26; 277(30):27169-75.
journal title abbreviation: J Biol Chem
publication date: 2002-05-22T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2.
PubMed Identifier: 12642602
author list: Wood N, Whitters MJ, Jacobson BA, Witek J, Sypek JP, Kasaian M, Eppihimer MJ, Unger M, Tanaka T, Goldman SJ, Collins M, Donaldson DD, Grusby MJ
published in: The Journal of experimental medicine
information resource reference: Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2. J Exp Med. 2003 Mar 17; 197(6):703-9.
journal title abbreviation: J Exp Med
publication date: 2003-03-17T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression.
PubMed Identifier: 15684054
author list: Mehta DS, Wurster AL, Weinmann AS, Grusby MJ
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression. Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):2016-21.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2005-01-31T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

NIP45 controls the magnitude of the type 2 T helper cell response.
PubMed Identifier: 20133688
author list: Fathman JW, Gurish MF, Hemmers S, Bonham K, Friend DS, Grusby MJ, Glimcher LH, Mowen KA
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: NIP45 controls the magnitude of the type 2 T helper cell response. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3663-8.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2010-02-04T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 108948
type: Authorship
author rank in publication: 6
linked author: Grusby, Michael
linked information resource: NIP45 controls the magnitude of the type 2 T helper cell response.

Authorship 109405
type: Authorship
author rank in publication: 4
linked author: Grusby, Michael
linked information resource: Truncation of the class II beta-chain cytoplasmic domain influences the level of class II/invariant chain-derived peptide complexes.

Synergistic effects of antigen and soluble T-cell factors in B-lymphocyte activation.
PubMed Identifier: 6089211
author list: Jelachich ML, Grusby MJ, Clark D, Tasch D, Margoliash E, Pierce SK
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Synergistic effects of antigen and soluble T-cell factors in B-lymphocyte activation. Proc Natl Acad Sci U S A. 1984 Sep; 81(17):5537-41.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1984-09-01T00:00:00
year: 1984
type: Academic Article
type: Article
type: Document
type: Information Resource

Immune responses in MHC class II-deficient mice.
PubMed Identifier: 7612230
author list: Grusby MJ, Glimcher LH
published in: Annual review of immunology
information resource reference: Immune responses in MHC class II-deficient mice. Annu Rev Immunol. 1995; 13:417-35.
journal title abbreviation: Annu Rev Immunol
publication date: 1995-01-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Th2 Cells
MeSH DescriptorUI: D018418
MeSH semantic group name: Anatomy
number of authors: 390
number of publications: 1063
uniqueness weight: 0.668626
type: Concept

Th1 Cells
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MeSH semantic group name: Anatomy
number of authors: 437
number of publications: 1041
uniqueness weight: 0.687335
type: Concept

Interleukin-4
MeSH DescriptorUI: D015847
MeSH semantic group name: Chemicals & Drugs
number of authors: 460
number of publications: 1149
uniqueness weight: 0.743448
type: Concept

Trans-Activators
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MeSH semantic group name: Chemicals & Drugs
number of authors: 992
number of publications: 2774
uniqueness weight: 0.51137
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Experimental Medicine Unit - CCIB
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Interleukins
MeSH DescriptorUI: D007378
MeSH semantic group name: Chemicals & Drugs
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uniqueness weight: 0.685826
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Center for Biostatistics in AIDS Research
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Epidemiology
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Health Policy and Management
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Immunology and Infectious Diseases
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Medicine
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Neurology
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Pediatrics
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Surgery
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Social and Behavioral Sciences
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Rheumatology
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Immunology
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Beth Israel Deaconess Medical Center
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Brigham and Women's Hospital
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Boston Children's Hospital
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Dana-Farber Cancer Institute
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Harvard T.H. Chan School of Public Health
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Massachusetts General Hospital
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Ho, I-Cheng
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Tassiopoulos, Katherine
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Glimcher, Laurie
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Adami, Hans-Olov
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Nobel, Jeremy
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Khoury, Samia
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Geha, Raif
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Auchincloss, Hugh
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Kuchroo, Vijay
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McCormick, Marie
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Authorship 132841
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author rank in publication: 15
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linked information resource: IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome.

Authorship 115636
type: Authorship
author rank in publication: 4
linked author: Grusby, Michael
linked information resource: Consequences of Stat6 deletion on Sis/PDGF- and IL-4-induced proliferation and transcriptional activation in murine fibroblasts.

Authorship 150248
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice.

Authorship 159363
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author rank in publication: 5
linked author: Grusby, Michael
linked information resource: Two levels of help for B cell alloantibody production.

Authorship 125875
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author rank in publication: 5
linked author: Grusby, Michael
linked information resource: Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity.

Professor of Medicine
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Authorship 129108
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author rank in publication: 5
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linked information resource: IL-12, STAT4-dependent up-regulation of CD4(+) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands.

Authorship 147325
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author rank in publication: 8
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linked information resource: Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption.

Authorship 161883
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linked information resource: Most gamma delta T cells develop normally in the absence of MHC class II molecules.

Authorship 127438
type: Authorship
author rank in publication: 1
linked author: Grusby, Michael
linked information resource: Mice lacking major histocompatibility complex class I and class II molecules.

Authorship 182479
type: Authorship
author rank in publication: 4
linked author: Grusby, Michael
linked information resource: IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression.

Authorship 183291
type: Authorship
author rank in publication: 4
linked author: Grusby, Michael
linked information resource: Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the disease.

Authorship 14253
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: Antigen-presenting function of B lymphocytes.

Authorship 157815
type: Authorship
author rank in publication: 6
linked author: Grusby, Michael
linked information resource: Colitis-inducing potency of CD4+ T cells in immunodeficient, adoptive hosts depends on their state of activation, IL-12 responsiveness, and CD45RB surface phenotype.

Authorship 197780
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author rank in publication: 4
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linked information resource: Absence of MHC class II molecules reduces CNS demyelination, microglial/macrophage infiltration, and twitching in murine globoid cell leukodystrophy.

Northwestern University,
end date: 1988
educational organization: Northwestern University
type: EducationalTraining
degree earned: Ph.D

Authorship 144081
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: Defining Th1 and Th2 immune responses in a reciprocal cytokine environment in vivo.

Authorship 222807
type: Authorship
author rank in publication: 13
linked author: Grusby, Michael
linked information resource: Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2.

Authorship 149481
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease.

Authorship 218020
type: Authorship
author rank in publication: 6
linked author: Grusby, Michael
linked information resource: IL-21 induces the apoptosis of resting and activated primary B cells.

Authorship 154055
type: Authorship
author rank in publication: 4
linked author: Grusby, Michael
linked information resource: Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response.

Authorship 165582
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells.

Authorship 209538
type: Authorship
author rank in publication: 5
linked author: Grusby, Michael
linked information resource: Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL.

Authorship 31733
type: Authorship
author rank in publication: 6
linked author: Grusby, Michael
linked information resource: PDLIM2 inhibits T helper 17 cell development and granulomatous inflammation through degradation of STAT3.

Authorship 338722
type: Authorship
author rank in publication: 1
linked author: Grusby, Michael
linked information resource: Immune responses in MHC class II-deficient mice.

Authorship 368977
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: Contribution of IL-12R mediated feedback loop to Th1 cell differentiation.

Authorship 451210
type: Authorship
author rank in publication: 5
linked author: Grusby, Michael
linked information resource: STAT6-deficient mice exhibit normal induction of murine AIDS and expression of immunoglobulin E following infection with LP-BM5 murine leukemia viruses.

Authorship 526873
type: Authorship
author rank in publication: 5
linked author: Grusby, Michael
linked information resource: DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target.

Authorship 217143
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: Effector cells must recognize antigens expressed in the graft to cause efficient skin graft rejection in SCID mice.

Authorship 234557
type: Authorship
author rank in publication: 4
linked author: Grusby, Michael
linked information resource: Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

Authorship 156472
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo.

Authorship 335617
type: Authorship
author rank in publication: 4
linked author: Grusby, Michael
linked information resource: Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development.

Authorship 342122
type: Authorship
author rank in publication: 4
linked author: Grusby, Michael
linked information resource: Identification of the small protein rich in arginine and glycine (SRAG): a newly identified nucleolar protein that can regulate cell proliferation.

Authorship 392670
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells.

Authorship 426507
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: Priming MHC-I-restricted cytotoxic T lymphocyte responses to exogenous hepatitis B surface antigen is CD4+ T cell dependent.

Authorship 427496
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit.

Associate Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Rheumatology
sort order: 1
type: Position
HR job title: Associate Professor of Medicine
position in organization: Brigham and Women's Hospital

Assistant Professor of Surgery
is primary position: true
position in department: Surgery
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Assistant Professor of Surgery
position in organization: Massachusetts General Hospital

Authorship 321390
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: Autoimmune diabetes can be induced in transgenic major histocompatibility complex class II-deficient mice.

Authorship 6568
type: Authorship
author rank in publication: 7
linked author: Grusby, Michael
linked information resource: Peripheral lymphoid development and function in TCR mutant mice.

Authorship 559720
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: The transcription factor NF-ATc is essential for cardiac valve formation.

Richard and Susan Smith Distinguished Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Rheumatology
sort order: 1
type: Position
HR job title: Richard and Susan Smith Distinguished Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Authorship 159247
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: CD8+ effector cells responding to residual class I antigens, with help from CD4+ cells stimulated indirectly, cause rejection of "major histocompatibility complex-deficient" skin grafts.

Authorship 326935
type: Authorship
author rank in publication: 5
linked author: Grusby, Michael
linked information resource: Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes.

Authorship 331156
type: Authorship
author rank in publication: 8
linked author: Grusby, Michael
linked information resource: Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy.

Authorship 60245
type: Authorship
author rank in publication: 4
linked author: Grusby, Michael
linked information resource: Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice.

Authorship 21599
type: Authorship
author rank in publication: 8
linked author: Grusby, Michael
linked information resource: CD1d-reactive T-cell activation leads to amelioration of disease caused by diabetogenic encephalomyocarditis virus.

Authorship 218724
type: Authorship
author rank in publication: 5
linked author: Grusby, Michael
linked information resource: Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells.

Authorship 258486
type: Authorship
author rank in publication: 1
linked author: Grusby, Michael
linked information resource: Induction of antigen-specific antibody responses by nonspecific T cell-derived helper factors.

Authorship 253379
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: Biology of IL-21 and the IL-21 receptor.

Authorship 273939
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice.

Authorship 274885
type: Authorship
author rank in publication: 1
linked author: Grusby, Michael
linked information resource: Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice.

Authorship 419102
type: Authorship
author rank in publication: 7
linked author: Grusby, Michael
linked information resource: Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells.

Authorship 282967
type: Authorship
author rank in publication: 5
linked author: Grusby, Michael
linked information resource: Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis.

Authorship 262345
type: Authorship
author rank in publication: 5
linked author: Grusby, Michael
linked information resource: Simultaneous deficiency in CD28 and STAT6 results in chronic ectoparasite-induced inflammatory skin disease.

Authorship 198860
type: Authorship
author rank in publication: 5
linked author: Grusby, Michael
linked information resource: The transcription factor NFAT4 is involved in the generation and survival of T cells.

Authorship 265310
type: Authorship
author rank in publication: 9
linked author: Grusby, Michael
linked information resource: Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc.

Authorship 245786
type: Authorship
author rank in publication: 10
linked author: Grusby, Michael
linked information resource: The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and ß cell function in mice.

Member of the Faculty of Medicine
is primary position: true
position in department: Medicine
position in division: Experimental Medicine Unit - CCIB
sort order: 1
type: Position
HR job title: Member of the Faculty of Medicine
position in organization: Massachusetts General Hospital

Colonna, Marco
first name: Marco
last name: Colonna
full name: Marco Colonna, M.D.
has faculty rank: Other Faculty
Person ID: 227720
person in primary position: Member of the Faculty of Medicine
type: Agent
type: Person
preferred title: Member of the Faculty of Medicine

Authorship 168853
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points.

Authorship 737617
type: Authorship
author rank in publication: 7
linked author: Grusby, Michael
linked information resource: IL-21 receptor signalling partially mediates Th2-mediated allergic airway responses.

IL-21 receptor signalling partially mediates Th2-mediated allergic airway responses.
PubMed Identifier: 24807637
author list: Lajoie S, Lewkowich I, Herman NS, Sproles A, Pesce JT, Wynn TA, Grusby MJ, Hamid Q, Wills-Karp M
published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
information resource reference: IL-21 receptor signalling partially mediates Th2-mediated allergic airway responses. Clin Exp Allergy. 2014 Jul; 44(7):976-85.
journal title abbreviation: Clin Exp Allergy
publication date: 2014-07-01T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Senior Lecturer on Neurology, Part-time
is primary position: true
position in department: Neurology
position in division: Neuroimmunology
sort order: 1
type: Position
HR job title: Senior Lecturer on Neurology, Part-time
position in organization: Brigham and Women's Hospital

Neuroimmunology
type: Division
type: Organization

Samuel L. Wasserstrom Professor of Neurology
is primary position: true
position in department: Neurology
position in division: Neuroimmunology
sort order: 1
type: Position
HR job title: Samuel L. Wasserstrom Professor of Neurology
position in organization: Brigham and Women's Hospital

Professor of Neurology
is primary position: true
position in department: Neurology
position in division: Neuroimmunology
sort order: 1
type: Position
HR job title: Professor of Neurology
position in organization: Brigham and Women's Hospital

Authorship 330706
type: Authorship
author rank in publication: 8
linked author: Grusby, Michael
linked information resource: Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway.

Senior Research Scientist
is primary position: true
position in department: Center for Biostatistics in AIDS Research
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Senior Research Scientist
position in organization: Harvard T.H. Chan School of Public Health

Sumner and Esther Feldberg Professor, Emerita
is primary position: true
position in department: Social and Behavioral Sciences
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Sumner and Esther Feldberg Professor, Emerita
position in organization: Harvard T.H. Chan School of Public Health

Professor of Epidemiology
is primary position: true
position in department: Epidemiology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Epidemiology
position in organization: Harvard T.H. Chan School of Public Health

Instructor
is primary position: true
position in department: Health Policy and Management
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Instructor
position in organization: Harvard T.H. Chan School of Public Health

Professor of Molecular Immunology, Emeritus
is primary position: true
position in department: Immunology and Infectious Diseases
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Molecular Immunology, Emeritus
position in organization: Harvard T.H. Chan School of Public Health

James L. Gamble Professor of Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Immunology
sort order: 1
type: Position
HR job title: James L. Gamble Professor of Pediatrics
position in organization: Boston Children's Hospital

Professor of Epidemiology, Emeritus
is primary position: true
position in department: Epidemiology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Epidemiology, Emeritus
position in organization: Harvard T.H. Chan School of Public Health

Authorship 460382
type: Authorship
author rank in publication: 7
linked author: Grusby, Michael
linked information resource: PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease.

Authorship 399138
type: Authorship
author rank in publication: 1
linked author: Grusby, Michael
linked information resource: Casein expression in cytotoxic T lymphocytes.

Authorship 217749
type: Authorship
author rank in publication: 6
linked author: Grusby, Michael
linked information resource: IL-21 promotes CD8+ CTL activity via the transcription factor T-bet.

Authorship 82230
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms.

Authorship 484336
type: Authorship
author rank in publication: 1
linked author: Grusby, Michael
linked information resource: Molecular cloning of mouse cathepsin D.

Authorship 388408
type: Authorship
author rank in publication: 9
linked author: Grusby, Michael
linked information resource: c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-beta inhibits c-Maf-induced IL-21 production in CD4+ T cells.

Authorship 450315
type: Authorship
author rank in publication: 4
linked author: Grusby, Michael
linked information resource: NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression.

Authorship 574498
type: Authorship
author rank in publication: 5
linked author: Grusby, Michael
linked information resource: Regulation of signal transducer and activator of transcription signaling by the tyrosine phosphatase PTP-BL.

Authorship 289349
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: Transcription of the interleukin 4 gene is regulated by multiple promoter elements.

Authorship 572861
type: Authorship
author rank in publication: 1
linked author: Grusby, Michael
linked information resource: Stat4- and Stat6-deficient mice as models for manipulating T helper cell responses.

Authorship 82391
type: Authorship
author rank in publication: 5
linked author: Grusby, Michael
linked information resource: CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism.

Authorship 408210
type: Authorship
author rank in publication: 6
linked author: Grusby, Michael
linked information resource: CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells.

Authorship 464471
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis.

Authorship 174616
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: Upstream elements of the MHC class II E beta gene active in B cells.

Authorship 225972
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: The biology of Stat4 and Stat6.

Authorship 65041
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: STATs as mediators of cytokine-induced responses.

Authorship 454489
type: Authorship
author rank in publication: 6
linked author: Grusby, Michael
linked information resource: A role for T helper 2 cells in mediating skin fibrosis in tight-skin mice.

Authorship 80248
type: Authorship
author rank in publication: 9
linked author: Grusby, Michael
linked information resource: The IL-21 receptor augments Th2 effector function and alternative macrophage activation.

Authorship 80506
type: Authorship
author rank in publication: 7
linked author: Grusby, Michael
linked information resource: Interleukin-21 is required for the development of type 1 diabetes in NOD mice.

Authorship 81884
type: Authorship
author rank in publication: 4
linked author: Grusby, Michael
linked information resource: STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination.

Authorship 88474
type: Authorship
author rank in publication: 6
linked author: Grusby, Michael
linked information resource: Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation.

Authorship 223471
type: Authorship
author rank in publication: 10
linked author: Grusby, Michael
linked information resource: Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response.

Authorship 265902
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma.

Authorship 250495
type: Authorship
author rank in publication: 4
linked author: Grusby, Michael
linked information resource: Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages.

Authorship 254476
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling.

Authorship 212775
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1.

Authorship 336888
type: Authorship
author rank in publication: 11
linked author: Grusby, Michael
linked information resource: An essential role in liver development for transcription factor XBP-1.

Authorship 432049
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: Regulation of T helper cell differentiation by STAT molecules.

Authorship 359989
type: Authorship
author rank in publication: 4
linked author: Grusby, Michael
linked information resource: Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets.

Authorship 396480
type: Authorship
author rank in publication: 4
linked author: Grusby, Michael
linked information resource: Positive selection of CD4+ T cells by TCR ligation without aggregation even in the absence of MHC.

Authorship 424667
type: Authorship
author rank in publication: 8
linked author: Grusby, Michael
linked information resource: Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity.

Authorship 40236
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen.

Authorship 231257
type: Authorship
author rank in publication: 4
linked author: Grusby, Michael
linked information resource: Stat proteins control lymphocyte proliferation by regulating p27Kip1 expression.

Authorship 259708
type: Authorship
author rank in publication: 5
linked author: Grusby, Michael
linked information resource: Marking IL-4-producing cells by knock-in of the IL-4 gene.

Authorship 403389
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines.

Authorship 368963
type: Authorship
author rank in publication: 5
linked author: Grusby, Michael
linked information resource: Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice.

Authorship 389071
type: Authorship
author rank in publication: 5
linked author: Grusby, Michael
linked information resource: IL-4 synergistically enhances both IL-2- and IL-12-induced IFN-gamma expression in murine NK cells.

Authorship 41611
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: Dual-receptor T cells expressing one self-restricted TCR.

Authorship 509866
type: Authorship
author rank in publication: 7
linked author: Grusby, Michael
linked information resource: Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.

Authorship 87728
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells.

Authorship 304921
type: Authorship
author rank in publication: 6
linked author: Grusby, Michael
linked information resource: Immunoregulatory effects of superantigens: interactions of staphylococcal enterotoxins with host MHC and non-MHC products.

Authorship 32333
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice.

Authorship 269844
type: Authorship
author rank in publication: 4
linked author: Grusby, Michael
linked information resource: Absence of T lymphocyte-derived cytokines fails to diminish macrophage 12/15-lipoxygenase expression in vivo.

Authorship 35440
type: Authorship
author rank in publication: 10
linked author: Grusby, Michael
linked information resource: The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo.

Authorship 4191
type: Authorship
author rank in publication: 6
linked author: Grusby, Michael
linked information resource: Positive selection of NKT cells by CD1(+), CD11c(+) non-lymphoid cells residing in the extrathymic organs.

Authorship 478080
type: Authorship
author rank in publication: 4
linked author: Grusby, Michael
linked information resource: Stat6-dependent and -independent pathways for IL-4 production.

Authorship 478403
type: Authorship
author rank in publication: 5
linked author: Grusby, Michael
linked information resource: Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis.

Authorship 476968
type: Authorship
author rank in publication: 5
linked author: Grusby, Michael
linked information resource: Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence.

Authorship 541078
type: Authorship
author rank in publication: 9
linked author: Grusby, Michael
linked information resource: Development and characterization of IL-21-producing CD4+ T cells.

Authorship 55415
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice.

Authorship 30907
type: Authorship
author rank in publication: 1
linked author: Grusby, Michael
linked information resource: Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase.

Authorship 363049
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: Genomic organization of the murine CTL lipase gene.

Authorship 443235
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: Activation of T cells by superantigen in class II-negative mice.

Authorship 495521
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: B lymphocyte development and activation independent of MHC class II expression.

Authorship 540111
type: Authorship
author rank in publication: 4
linked author: Grusby, Michael
linked information resource: Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production.

Authorship 397869
type: Authorship
author rank in publication: 15
linked author: Grusby, Michael
linked information resource: IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity.

Authorship 472487
type: Authorship
author rank in publication: 14
linked author: Grusby, Michael
linked information resource: Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice.

Authorship 476801
type: Authorship
author rank in publication: 8
linked author: Grusby, Michael
linked information resource: Plasma cell differentiation requires the transcription factor XBP-1.

Authorship 55004
type: Authorship
author rank in publication: 7
linked author: Grusby, Michael
linked information resource: Zinc finger protein Zbtb20 is essential for postnatal survival and glucose homeostasis.

Authorship 574745
type: Authorship
author rank in publication: 5
linked author: Grusby, Michael
linked information resource: Decreased neonatal dietary fat absorption and T cell cytotoxicity in pancreatic lipase-related protein 2-deficient mice.

Authorship 58275
type: Authorship
author rank in publication: 6
linked author: Grusby, Michael
linked information resource: PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation.

Authorship 73733
type: Authorship
author rank in publication: 5
linked author: Grusby, Michael
linked information resource: Transgenic mice expressing MHC class II molecules with truncated A beta cytoplasmic domains reveal signaling-independent defects in antigen presentation.

Authorship 81403
type: Authorship
author rank in publication: 7
linked author: Grusby, Michael
linked information resource: Stat4 regulates multiple components of IFN-gamma-inducing signaling pathways.

Authorship 876804
type: Authorship
author rank in publication: 15
linked author: Grusby, Michael
linked information resource: ZBTB20 is required for anterior pituitary development and lactotrope specification.

ZBTB20 is required for anterior pituitary development and lactotrope specification.
PubMed Identifier: 27079169
author list: Cao D, Ma X, Cai J, Luan J, Liu AJ, Yang R, Cao Y, Zhu X, Zhang H, Chen YX, Shi Y, Shi GX, Zou D, Cao X, Grusby MJ, Xie Z, Zhang WJ
published in: Nature communications
information resource reference: ZBTB20 is required for anterior pituitary development and lactotrope specification. Nat Commun. 2016 Apr 15; 7:11121.
journal title abbreviation: Nat Commun
publication date: 2016-04-15T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 475165
type: Authorship
author rank in publication: 8
linked author: Grusby, Michael
linked information resource: IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung.

Authorship 484360
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: Synergistic effects of antigen and soluble T-cell factors in B-lymphocyte activation.

Assistant Professor
sort order: 2
type: Faculty Rank

Associate Professor
sort order: 1
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Instructor
sort order: 4
type: Faculty Rank

Lecturer
sort order: 3
type: Faculty Rank

Other Faculty
sort order: 5
type: Faculty Rank

Authorship 80697
type: Authorship
author rank in publication: 7
linked author: Grusby, Michael
linked information resource: Role of STAT6 signaling in the induction and long-term maintenance of tolerance mediated by CTLA4-Ig.

Authorship 514834
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi.

REGULATION OF STAT FUNCTION
end date: 2005-01-31
principal investigator name: GRUSBY, MICHAEL J
start date: 2001-02-01
type: Grant
sponsor award id: R01GM062135

MOLECULAR AND GENETIC ANALYSIS OF CTL MEDIATED LYSIS
end date: 1997-04-30
principal investigator name: GRUSBY, MICHAEL J
start date: 1992-05-01
type: Grant
sponsor award id: R29CA056462

Regulation of Differentiation &Function of TH2 Cells
end date: 2008-02-28
principal investigator name: GRUSBY, MICHAEL J
start date: 1997-05-01
type: Grant
sponsor award id: R01AI040171

ALTERING INTERLEUKIN 4 FUNCTION IN VIVO
end date: 1997-09-14
principal investigator name: GRUSBY, MICHAEL J
start date: 1996-09-15
type: Grant
sponsor award id: R21AI040171

Principal Investigator
type: Researcher Role
researcher role of: Grusby, Michael
contributes to: ALTERING INTERLEUKIN 4 FUNCTION IN VIVO

Principal Investigator
type: Researcher Role
researcher role of: Grusby, Michael
contributes to: MOLECULAR AND GENETIC ANALYSIS OF CTL MEDIATED LYSIS

Principal Investigator
type: Researcher Role
researcher role of: Grusby, Michael
contributes to: Regulation of Differentiation &Function of TH2 Cells

Principal Investigator
type: Researcher Role
researcher role of: Grusby, Michael
contributes to: REGULATION OF STAT FUNCTION

Authorship 76600
type: Authorship
author rank in publication: 3
linked author: Grusby, Michael
linked information resource: Cross-linking of protein S bound to lymphocytes promotes aggregation and inhibits proliferation.

Authorship 321032
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages.

Authorship 199151
type: Authorship
author rank in publication: 11
linked author: Grusby, Michael
linked information resource: Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver.

Authorship 219643
type: Authorship
author rank in publication: 6
linked author: Grusby, Michael
linked information resource: IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma.

Authorship 493580
type: Authorship
author rank in publication: 2
linked author: Grusby, Michael
linked information resource: Identification of an IL-4-inducible gene expressed in differentiating lymphocytes and male germ cells.

677 Huntington Ave
type: Address
address line 1: Harvard School of Public Health
address line 2: Kresge 1001A
address line 3: 677 Huntington Ave
city: Boston
postal code: 02115
state or province: MA

Cross-linking of protein S bound to lymphocytes promotes aggregation and inhibits proliferation.
PubMed Identifier: 9398399
author list: Smiley ST, Stitt TN, Grusby MJ
published in: Cellular immunology
information resource reference: Cross-linking of protein S bound to lymphocytes promotes aggregation and inhibits proliferation. Cell Immunol. 1997 Nov 01; 181(2):120-6.
journal title abbreviation: Cell Immunol
publication date: 1997-11-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice.
PubMed Identifier: 11457897
author list: Daheshia M, Friend DS, Grusby MJ, Austen KF, Katz HR
published in: The Journal of experimental medicine
information resource reference: Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice. J Exp Med. 2001 Jul 16; 194(2):227-34.
journal title abbreviation: J Exp Med
publication date: 2001-07-16T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells.
PubMed Identifier: 12370258
author list: Wurster AL, Rodgers VL, Satoskar AR, Whitters MJ, Young DA, Collins M, Grusby MJ
published in: The Journal of experimental medicine
information resource reference: Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells. J Exp Med. 2002 Oct 07; 196(7):969-77.
journal title abbreviation: J Exp Med
publication date: 2002-10-07T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Defining Th1 and Th2 immune responses in a reciprocal cytokine environment in vivo.
PubMed Identifier: 15034039
author list: Chitnis T, Salama AD, Grusby MJ, Sayegh MH, Khoury SJ
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Defining Th1 and Th2 immune responses in a reciprocal cytokine environment in vivo. J Immunol. 2004 Apr 01; 172(7):4260-5.
journal title abbreviation: J Immunol
publication date: 2004-04-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Upstream elements of the MHC class II E beta gene active in B cells.
PubMed Identifier: 1903416
author list: Finn PW, Kara CJ, Grusby MJ, Folsom V, Glimcher LH
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Upstream elements of the MHC class II E beta gene active in B cells. J Immunol. 1991 Jun 01; 146(11):4011-5.
journal title abbreviation: J Immunol
publication date: 1991-06-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Colitis-inducing potency of CD4+ T cells in immunodeficient, adoptive hosts depends on their state of activation, IL-12 responsiveness, and CD45RB surface phenotype.
PubMed Identifier: 10092833
author list: Claesson MH, Bregenholt S, Bonhagen K, Thoma S, Möller P, Grusby MJ, Leithäuser F, Nissen MH, Reimann J
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Colitis-inducing potency of CD4+ T cells in immunodeficient, adoptive hosts depends on their state of activation, IL-12 responsiveness, and CD45RB surface phenotype. J Immunol. 1999 Mar 15; 162(6):3702-10.
journal title abbreviation: J Immunol
publication date: 1999-03-15T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development.
PubMed Identifier: 10097114
author list: Kim JI, Li T, Ho IC, Grusby MJ, Glimcher LH
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3781-5.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1999-03-30T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.
PubMed Identifier: 11067913
author list: Zhou P, Szot GL, Guo Z, Kim O, He G, Wang J, Grusby MJ, Newell KA, Thistlethwaite JR, Bluestone JA, Alegre ML
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance. J Immunol. 2000 Nov 15; 165(10):5580-7.
journal title abbreviation: J Immunol
publication date: 2000-11-15T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines.
PubMed Identifier: 10403649
author list: Kim JI, Ho IC, Grusby MJ, Glimcher LH
published in: Immunity
information resource reference: The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. Immunity. 1999 Jun; 10(6):745-51.
journal title abbreviation: Immunity
publication date: 1999-06-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Consequences of Stat6 deletion on Sis/PDGF- and IL-4-induced proliferation and transcriptional activation in murine fibroblasts.
PubMed Identifier: 10602484
author list: Kriebel P, Patel BK, Nelson SA, Grusby MJ, LaRochelle WJ
published in: Oncogene
information resource reference: Consequences of Stat6 deletion on Sis/PDGF- and IL-4-induced proliferation and transcriptional activation in murine fibroblasts. Oncogene. 1999 Dec 02; 18(51):7294-302.
journal title abbreviation: Oncogene
publication date: 1999-12-02T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Stat4- and Stat6-deficient mice as models for manipulating T helper cell responses.
PubMed Identifier: 9191117
author list: Grusby MJ
published in: Biochemical Society transactions
information resource reference: Stat4- and Stat6-deficient mice as models for manipulating T helper cell responses. Biochem Soc Trans. 1997 May; 25(2):359-60.
journal title abbreviation: Biochem Soc Trans
publication date: 1997-05-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response.
PubMed Identifier: 9469446
author list: Kaplan MH, Whitfield JR, Boros DL, Grusby MJ
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response. J Immunol. 1998 Feb 15; 160(4):1850-6.
journal title abbreviation: J Immunol
publication date: 1998-02-15T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells.
PubMed Identifier: 10227985
author list: Shi HN, Grusby MJ, Nagler-Anderson C
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells. J Immunol. 1999 May 01; 162(9):5143-8.
journal title abbreviation: J Immunol
publication date: 1999-05-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice.
PubMed Identifier: 19075398
author list: Jin H, Oyoshi MK, Le Y, Bianchi T, Koduru S, Mathias CB, Kumar L, Le Bras S, Young D, Collins M, Grusby MJ, Wenzel J, Bieber T, Boes M, Silberstein LE, Oettgen HC, Geha RS
published in: The Journal of clinical investigation
information resource reference: IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. J Clin Invest. 2009 Jan; 119(1):47-60.
journal title abbreviation: J Clin Invest
publication date: 2008-12-15T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target.
PubMed Identifier: 20145149
author list: Qu Z, Yan P, Fu J, Jiang J, Grusby MJ, Smithgall TE, Xiao G
published in: Cancer research
information resource reference: DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target. Cancer Res. 2010 Mar 01; 70(5):1766-72.
journal title abbreviation: Cancer Res
publication date: 2010-02-09T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response.
PubMed Identifier: 12642601
author list: Chiaramonte MG, Mentink-Kane M, Jacobson BA, Cheever AW, Whitters MJ, Goad ME, Wong A, Collins M, Donaldson DD, Grusby MJ, Wynn TA
published in: The Journal of experimental medicine
information resource reference: Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J Exp Med. 2003 Mar 17; 197(6):687-701.
journal title abbreviation: J Exp Med
publication date: 2003-03-17T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

STAT6-deficient mice exhibit normal induction of murine AIDS and expression of immunoglobulin E following infection with LP-BM5 murine leukemia viruses.
PubMed Identifier: 10400816
author list: Morse HC, McCarty T, Giese NA, Taddesse-Heath L, Grusby MJ
published in: Journal of virology
information resource reference: STAT6-deficient mice exhibit normal induction of murine AIDS and expression of immunoglobulin E following infection with LP-BM5 murine leukemia viruses. J Virol. 1999 Aug; 73(8):7093-5.
journal title abbreviation: J Virol
publication date: 1999-08-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

An essential role in liver development for transcription factor XBP-1.
PubMed Identifier: 10652269
author list: Reimold AM, Etkin A, Clauss I, Perkins A, Friend DS, Zhang J, Horton HF, Scott A, Orkin SH, Byrne MC, Grusby MJ, Glimcher LH
published in: Genes & development
information resource reference: An essential role in liver development for transcription factor XBP-1. Genes Dev. 2000 Jan 15; 14(2):152-7.
journal title abbreviation: Genes Dev
publication date: 2000-01-15T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity.
PubMed Identifier: 11970879
author list: Kasaian MT, Whitters MJ, Carter LL, Lowe LD, Jussif JM, Deng B, Johnson KA, Witek JS, Senices M, Konz RF, Wurster AL, Donaldson DD, Collins M, Young DA, Grusby MJ
published in: Immunity
information resource reference: IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity. 2002 Apr; 16(4):559-69.
journal title abbreviation: Immunity
publication date: 2002-04-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

The IL-21 receptor augments Th2 effector function and alternative macrophage activation.
PubMed Identifier: 16778988
author list: Pesce J, Kaviratne M, Ramalingam TR, Thompson RW, Urban JF, Cheever AW, Young DA, Collins M, Grusby MJ, Wynn TA
published in: The Journal of clinical investigation
information resource reference: The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J Clin Invest. 2006 Jul; 116(7):2044-55.
journal title abbreviation: J Clin Invest
publication date: 2006-06-15T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells.
PubMed Identifier: 9880256
author list: Schofield L, McConville MJ, Hansen D, Campbell AS, Fraser-Reid B, Grusby MJ, Tachado SD
published in: Science (New York, N.Y.)
information resource reference: CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells. Science. 1999 Jan 08; 283(5399):225-9.
journal title abbreviation: Science
publication date: 1999-01-08T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

A role for T helper 2 cells in mediating skin fibrosis in tight-skin mice.
PubMed Identifier: 10486156
author list: Ong CJ, Ip S, Teh SJ, Wong C, Jirik FR, Grusby MJ, Teh HS
published in: Cellular immunology
information resource reference: A role for T helper 2 cells in mediating skin fibrosis in tight-skin mice. Cell Immunol. 1999 Aug 25; 196(1):60-8.
journal title abbreviation: Cell Immunol
publication date: 1999-08-25T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Positive selection of NKT cells by CD1(+), CD11c(+) non-lymphoid cells residing in the extrathymic organs.
PubMed Identifier: 10602005
author list: Shimamura M, Huang YY, Suda Y, Kusumoto S, Sato K, Grusby MJ, Sato H, Nakayama T, Taniguchi M
published in: European journal of immunology
information resource reference: Positive selection of NKT cells by CD1(+), CD11c(+) non-lymphoid cells residing in the extrathymic organs. Eur J Immunol. 1999 12; 29(12):3962-70.
journal title abbreviation: Eur J Immunol
publication date: 1999-12-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Dual-receptor T cells expressing one self-restricted TCR.
PubMed Identifier: 9201314
author list: Smiley ST, Grusby MJ
published in: Scandinavian journal of immunology
information resource reference: Dual-receptor T cells expressing one self-restricted TCR. Scand J Immunol. 1997 Jun; 45(6):726-30.
journal title abbreviation: Scand J Immunol
publication date: 1997-06-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc.
PubMed Identifier: 9462518
author list: Ranger AM, Hodge MR, Gravallese EM, Oukka M, Davidson L, Alt FW, de la Brousse FC, Hoey T, Grusby M, Glimcher LH
published in: Immunity
information resource reference: Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity. 1998 Jan; 8(1):125-34.
journal title abbreviation: Immunity
publication date: 1998-01-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production.
PubMed Identifier: 9500796
author list: Kuperman D, Schofield B, Wills-Karp M, Grusby MJ
published in: The Journal of experimental medicine
information resource reference: Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J Exp Med. 1998 Mar 16; 187(6):939-48.
journal title abbreviation: J Exp Med
publication date: 1998-03-16T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma.
PubMed Identifier: 11086031
author list: Ostrand-Rosenberg S, Grusby MJ, Clements VK
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Cutting edge: STAT6-deficient mice have enhanced tumor immunity to primary and metastatic mammary carcinoma. J Immunol. 2000 Dec 01; 165(11):6015-9.
journal title abbreviation: J Immunol
publication date: 2000-12-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism.
PubMed Identifier: 12574364
author list: Chung DR, Kasper DL, Panzo RJ, Chitnis T, Grusby MJ, Sayegh MH, Tzianabos AO, Chtinis T
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism. J Immunol. 2003 Feb 15; 170(4):1958-63.
journal title abbreviation: J Immunol
publication date: 2003-02-15T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Genomic organization of the murine CTL lipase gene.
PubMed Identifier: 8812501
author list: Kaplan MH, Boyer SN, Grusby MJ
published in: Genomics
information resource reference: Genomic organization of the murine CTL lipase gene. Genomics. 1996 Aug 01; 35(3):606-9.
journal title abbreviation: Genomics
publication date: 1996-08-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

The biology of Stat4 and Stat6.
PubMed Identifier: 10851056
author list: Wurster AL, Tanaka T, Grusby MJ
published in: Oncogene
information resource reference: The biology of Stat4 and Stat6. Oncogene. 2000 May 15; 19(21):2577-84.
journal title abbreviation: Oncogene
publication date: 2000-05-15T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Simultaneous deficiency in CD28 and STAT6 results in chronic ectoparasite-induced inflammatory skin disease.
PubMed Identifier: 15213110
author list: Liu Q, Arseculeratne C, Liu Z, Whitmire J, Grusby MJ, Finkelman FD, Darling TN, Cheever AW, Swearengen J, Urban JF, Gause WC
published in: Infection and immunity
information resource reference: Simultaneous deficiency in CD28 and STAT6 results in chronic ectoparasite-induced inflammatory skin disease. Infect Immun. 2004 Jul; 72(7):3706-15.
journal title abbreviation: Infect Immun
publication date: 2004-07-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation.
PubMed Identifier: 9379007
author list: Herold KC, Lu J, Rulifson I, Vezys V, Taub D, Grusby MJ, Bluestone JA
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation. J Immunol. 1997 Nov 01; 159(9):4150-3.
journal title abbreviation: J Immunol
publication date: 1997-11-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

The transcription factor NFAT4 is involved in the generation and survival of T cells.
PubMed Identifier: 9768749
author list: Oukka M, Ho IC, de la Brousse FC, Hoey T, Grusby MJ, Glimcher LH
published in: Immunity
information resource reference: The transcription factor NFAT4 is involved in the generation and survival of T cells. Immunity. 1998 Sep; 9(3):295-304.
journal title abbreviation: Immunity
publication date: 1998-09-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells.
PubMed Identifier: 9020080
author list: Smiley ST, Kaplan MH, Grusby MJ
published in: Science (New York, N.Y.)
information resource reference: Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science. 1997 Feb 14; 275(5302):977-9.
journal title abbreviation: Science
publication date: 1997-02-14T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Absence of T lymphocyte-derived cytokines fails to diminish macrophage 12/15-lipoxygenase expression in vivo.
PubMed Identifier: 9686614
author list: Sendobry SM, Cornicelli JA, Welch K, Grusby MJ, Daugherty A
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Absence of T lymphocyte-derived cytokines fails to diminish macrophage 12/15-lipoxygenase expression in vivo. J Immunol. 1998 Aug 01; 161(3):1477-82.
journal title abbreviation: J Immunol
publication date: 1998-08-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes.
PubMed Identifier: 9759842
author list: Burdin N, Brossay L, Koezuka Y, Smiley ST, Grusby MJ, Gui M, Taniguchi M, Hayakawa K, Kronenberg M
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes. J Immunol. 1998 Oct 01; 161(7):3271-81.
journal title abbreviation: J Immunol
publication date: 1998-10-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms.
PubMed Identifier: 12218156
author list: Finnegan A, Grusby MJ, Kaplan CD, O'Neill SK, Eibel H, Koreny T, Czipri M, Mikecz K, Zhang J
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms. J Immunol. 2002 Sep 15; 169(6):3345-52.
journal title abbreviation: J Immunol
publication date: 2002-09-15T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets.
PubMed Identifier: 10792004
author list: Nikolic B, Lee S, Bronson RT, Grusby MJ, Sykes M
published in: The Journal of clinical investigation
information resource reference: Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets. J Clin Invest. 2000 May; 105(9):1289-98.
journal title abbreviation: J Clin Invest
publication date: 2000-05-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation.
PubMed Identifier: 19131544
author list: Yan P, Fu J, Qu Z, Li S, Tanaka T, Grusby MJ, Xiao G
published in: Blood
information resource reference: PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation. Blood. 2009 Apr 30; 113(18):4370-80.
journal title abbreviation: Blood
publication date: 2009-01-08T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome.
PubMed Identifier: 17182591
author list: Keane MP, Gomperts BN, Weigt S, Xue YY, Burdick MD, Nakamura H, Zisman DA, Ardehali A, Saggar R, Lynch JP, Hogaboam C, Kunkel SL, Lukacs NW, Ross DJ, Grusby MJ, Strieter RM, Belperio JA
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome. J Immunol. 2007 Jan 01; 178(1):511-9.
journal title abbreviation: J Immunol
publication date: 2007-01-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

IL-12, STAT4-dependent up-regulation of CD4(+) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands.
PubMed Identifier: 11591774
author list: Lim YC, Xie H, Come CE, Alexander SI, Grusby MJ, Lichtman AH, Luscinskas FW
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: IL-12, STAT4-dependent up-regulation of CD4(+) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands. J Immunol. 2001 Oct 15; 167(8):4476-84.
journal title abbreviation: J Immunol
publication date: 2001-10-15T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1.
PubMed Identifier: 12221108
author list: Eyles JL, Metcalf D, Grusby MJ, Hilton DJ, Starr R
published in: The Journal of biological chemistry
information resource reference: Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1. J Biol Chem. 2002 Nov 15; 277(46):43735-40.
journal title abbreviation: J Biol Chem
publication date: 2002-09-08T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase.
PubMed Identifier: 2302735
author list: Grusby MJ, Nabavi N, Wong H, Dick RF, Bluestone JA, Schotz MC, Glimcher LH
published in: Cell
information resource reference: Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase. Cell. 1990 Feb 09; 60(3):451-9.
journal title abbreviation: Cell
publication date: 1990-02-09T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of signal transducer and activator of transcription signaling by the tyrosine phosphatase PTP-BL.
PubMed Identifier: 17306571
author list: Nakahira M, Tanaka T, Robson BE, Mizgerd JP, Grusby MJ
published in: Immunity
information resource reference: Regulation of signal transducer and activator of transcription signaling by the tyrosine phosphatase PTP-BL. Immunity. 2007 Feb; 26(2):163-76.
journal title abbreviation: Immunity
publication date: 2007-02-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of T helper cell differentiation by STAT molecules.
PubMed Identifier: 9665267
author list: Kaplan MH, Grusby MJ
published in: Journal of leukocyte biology
information resource reference: Regulation of T helper cell differentiation by STAT molecules. J Leukoc Biol. 1998 Jul; 64(1):2-5.
journal title abbreviation: J Leukoc Biol
publication date: 1998-07-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis.
PubMed Identifier: 10377193
author list: Behar SM, Dascher CC, Grusby MJ, Wang CR, Brenner MB
published in: The Journal of experimental medicine
information resource reference: Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis. J Exp Med. 1999 Jun 21; 189(12):1973-80.
journal title abbreviation: J Exp Med
publication date: 1999-06-21T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Priming MHC-I-restricted cytotoxic T lymphocyte responses to exogenous hepatitis B surface antigen is CD4+ T cell dependent.
PubMed Identifier: 10438922
author list: Wild J, Grusby MJ, Schirmbeck R, Reimann J
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Priming MHC-I-restricted cytotoxic T lymphocyte responses to exogenous hepatitis B surface antigen is CD4+ T cell dependent. J Immunol. 1999 Aug 15; 163(4):1880-7.
journal title abbreviation: J Immunol
publication date: 1999-08-15T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

IL-21 induces the apoptosis of resting and activated primary B cells.
PubMed Identifier: 12682241
author list: Mehta DS, Wurster AL, Whitters MJ, Young DA, Collins M, Grusby MJ
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: IL-21 induces the apoptosis of resting and activated primary B cells. J Immunol. 2003 Apr 15; 170(8):4111-8.
journal title abbreviation: J Immunol
publication date: 2003-04-15T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Antigen-presenting function of B lymphocytes.
PubMed Identifier: 3075588
author list: Pierce SK, Morris JF, Grusby MJ, Kaumaya P, van Buskirk A, Srinivasan M, Crump B, Smolenski LA
published in: Immunological reviews
information resource reference: Antigen-presenting function of B lymphocytes. Immunol Rev. 1988 Dec; 106:149-80.
journal title abbreviation: Immunol Rev
publication date: 1988-12-01T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

Mice lacking major histocompatibility complex class I and class II molecules.
PubMed Identifier: 8483910
author list: Grusby MJ, Auchincloss H, Lee R, Johnson RS, Spencer JP, Zijlstra M, Jaenisch R, Papaioannou VE, Glimcher LH
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Mice lacking major histocompatibility complex class I and class II molecules. Proc Natl Acad Sci U S A. 1993 May 01; 90(9):3913-7.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1993-05-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease.
PubMed Identifier: 8671585
author list: Tarleton RL, Grusby MJ, Postan M, Glimcher LH
published in: International immunology
information resource reference: Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease. Int Immunol. 1996 Jan; 8(1):13-22.
journal title abbreviation: Int Immunol
publication date: 1996-01-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Biology of IL-21 and the IL-21 receptor.
PubMed Identifier: 15546387
author list: Mehta DS, Wurster AL, Grusby MJ
published in: Immunological reviews
information resource reference: Biology of IL-21 and the IL-21 receptor. Immunol Rev. 2004 Dec; 202:84-95.
journal title abbreviation: Immunol Rev
publication date: 2004-12-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi.
PubMed Identifier: 10903759
author list: Tarleton RL, Grusby MJ, Zhang L
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi. J Immunol. 2000 Aug 01; 165(3):1520-5.
journal title abbreviation: J Immunol
publication date: 2000-08-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Casein expression in cytotoxic T lymphocytes.
PubMed Identifier: 2395885
author list: Grusby MJ, Mitchell SC, Nabavi N, Glimcher LH
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Casein expression in cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 1990 Sep; 87(17):6897-901.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1990-09-01T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Interleukin-21 is required for the development of type 1 diabetes in NOD mice.
PubMed Identifier: 19208913
author list: Sutherland AP, Van Belle T, Wurster AL, Suto A, Michaud M, Zhang D, Grusby MJ, von Herrath M
published in: Diabetes
information resource reference: Interleukin-21 is required for the development of type 1 diabetes in NOD mice. Diabetes. 2009 May; 58(5):1144-55.
journal title abbreviation: Diabetes
publication date: 2009-02-10T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Induction of antigen-specific antibody responses by nonspecific T cell-derived helper factors.
PubMed Identifier: 2952746
author list: Grusby MJ, Pierce SK
published in: Immunologic research
information resource reference: Induction of antigen-specific antibody responses by nonspecific T cell-derived helper factors. Immunol Res. 1986; 5(3):201-9.
journal title abbreviation: Immunol Res
publication date: 1986-01-01T00:00:00
year: 1986
type: Academic Article
type: Article
type: Document
type: Information Resource

Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice.
PubMed Identifier: 7908320
author list: Jevnikar AM, Grusby MJ, Glimcher LH
published in: The Journal of experimental medicine
information resource reference: Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice. J Exp Med. 1994 Apr 01; 179(4):1137-43.
journal title abbreviation: J Exp Med
publication date: 1994-04-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.
PubMed Identifier: 8624821
author list: Kaplan MH, Schindler U, Smiley ST, Grusby MJ
published in: Immunity
information resource reference: Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity. 1996 Mar; 4(3):313-9.
journal title abbreviation: Immunity
publication date: 1996-03-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination.
PubMed Identifier: 9647237
author list: Linehan LA, Warren WD, Thompson PA, Grusby MJ, Berton MT
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination. J Immunol. 1998 Jul 01; 161(1):302-10.
journal title abbreviation: J Immunol
publication date: 1998-07-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

STATs as mediators of cytokine-induced responses.
PubMed Identifier: 9917912
author list: Hoey T, Grusby MJ
published in: Advances in immunology
information resource reference: STATs as mediators of cytokine-induced responses. Adv Immunol. 1999; 71:145-62.
journal title abbreviation: Adv Immunol
publication date: 1999-01-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the disease.
PubMed Identifier: 7751707
author list: Chakkalath HR, Theodos CM, Markowitz JS, Grusby MJ, Glimcher LH, Titus RG
published in: The Journal of infectious diseases
information resource reference: Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the disease. J Infect Dis. 1995 May; 171(5):1302-8.
journal title abbreviation: J Infect Dis
publication date: 1995-05-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway.
PubMed Identifier: 10549628
author list: Homann D, Holz A, Bot A, Coon B, Wolfe T, Petersen J, Dyrberg TP, Grusby MJ, von Herrath MG
published in: Immunity
information resource reference: Autoreactive CD4+ T cells protect from autoimmune diabetes via bystander suppression using the IL-4/Stat6 pathway. Immunity. 1999 Oct; 11(4):463-72.
journal title abbreviation: Immunity
publication date: 1999-10-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice.
PubMed Identifier: 1910207
author list: Grusby MJ, Johnson RS, Papaioannou VE, Glimcher LH
published in: Science (New York, N.Y.)
information resource reference: Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice. Science. 1991 Sep 20; 253(5026):1417-20.
journal title abbreviation: Science
publication date: 1991-09-20T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular cloning of mouse cathepsin D.
PubMed Identifier: 2374732
author list: Grusby MJ, Mitchell SC, Glimcher LH
published in: Nucleic acids research
information resource reference: Molecular cloning of mouse cathepsin D. Nucleic Acids Res. 1990 Jul 11; 18(13):4008.
journal title abbreviation: Nucleic Acids Res
publication date: 1990-07-11T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Role of group V phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption.
PubMed Identifier: 14761945
author list: Satake Y, Diaz BL, Balestrieri B, Lam BK, Kanaoka Y, Grusby MJ, Arm JP
published in: The Journal of biological chemistry
information resource reference: Role of group V phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption. J Biol Chem. 2004 Apr 16; 279(16):16488-94.
journal title abbreviation: J Biol Chem
publication date: 2004-02-04T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

B lymphocyte development and activation independent of MHC class II expression.
PubMed Identifier: 8432977
author list: Markowitz JS, Rogers PR, Grusby MJ, Parker DC, Glimcher LH
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: B lymphocyte development and activation independent of MHC class II expression. J Immunol. 1993 Feb 15; 150(4):1223-33.
journal title abbreviation: J Immunol
publication date: 1993-02-15T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Activation of T cells by superantigen in class II-negative mice.
PubMed Identifier: 7963549
author list: Avery AC, Markowitz JS, Grusby MJ, Glimcher LH, Cantor H
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Activation of T cells by superantigen in class II-negative mice. J Immunol. 1994 Dec 01; 153(11):4853-61.
journal title abbreviation: J Immunol
publication date: 1994-12-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Peripheral lymphoid development and function in TCR mutant mice.
PubMed Identifier: 7947457
author list: Mombaerts P, Mizoguchi E, Ljunggren HG, Iacomini J, Ishikawa H, Wang L, Grusby MJ, Glimcher LH, Winn HJ, Bhan AK
published in: International immunology
information resource reference: Peripheral lymphoid development and function in TCR mutant mice. Int Immunol. 1994 Jul; 6(7):1061-70.
journal title abbreviation: Int Immunol
publication date: 1994-07-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Most gamma delta T cells develop normally in the absence of MHC class II molecules.
PubMed Identifier: 8409413
author list: Bigby M, Markowitz JS, Bleicher PA, Grusby MJ, Simha S, Siebrecht M, Wagner M, Nagler-Anderson C, Glimcher LH
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Most gamma delta T cells develop normally in the absence of MHC class II molecules. J Immunol. 1993 Nov 01; 151(9):4465-75.
journal title abbreviation: J Immunol
publication date: 1993-11-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption.
PubMed Identifier: 17641034
author list: Touma M, Antonini V, Kumar M, Osborn SL, Bobenchik AM, Keskin DB, Connolly JE, Grusby MJ, Reinherz EL, Clayton LK
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption. J Immunol. 2007 Aug 01; 179(3):1681-92.
journal title abbreviation: J Immunol
publication date: 2007-08-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Transgenic mice expressing MHC class II molecules with truncated A beta cytoplasmic domains reveal signaling-independent defects in antigen presentation.
PubMed Identifier: 7547694
author list: Smiley ST, Laufer TM, Lo D, Glimcher LH, Grusby MJ
published in: International immunology
information resource reference: Transgenic mice expressing MHC class II molecules with truncated A beta cytoplasmic domains reveal signaling-independent defects in antigen presentation. Int Immunol. 1995 Apr; 7(4):665-77.
journal title abbreviation: Int Immunol
publication date: 1995-04-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of the small protein rich in arginine and glycine (SRAG): a newly identified nucleolar protein that can regulate cell proliferation.
PubMed Identifier: 19254951
author list: Zullo AJ, Michaud M, Zhang W, Grusby MJ
published in: The Journal of biological chemistry
information resource reference: Identification of the small protein rich in arginine and glycine (SRAG): a newly identified nucleolar protein that can regulate cell proliferation. J Biol Chem. 2009 May 01; 284(18):12504-11.
journal title abbreviation: J Biol Chem
publication date: 2009-03-02T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Zinc finger protein Zbtb20 is essential for postnatal survival and glucose homeostasis.
PubMed Identifier: 19273596
author list: Sutherland AP, Zhang H, Zhang Y, Michaud M, Xie Z, Patti ME, Grusby MJ, Zhang WJ
published in: Molecular and cellular biology
information resource reference: Zinc finger protein Zbtb20 is essential for postnatal survival and glucose homeostasis. Mol Cell Biol. 2009 May; 29(10):2804-15.
journal title abbreviation: Mol Cell Biol
publication date: 2009-03-09T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells.
PubMed Identifier: 9743537
author list: Kaplan MH, Wurster AL, Grusby MJ
published in: The Journal of experimental medicine
information resource reference: A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells. J Exp Med. 1998 Sep 21; 188(6):1191-6.
journal title abbreviation: J Exp Med
publication date: 1998-09-21T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

The transcription factor NF-ATc is essential for cardiac valve formation.
PubMed Identifier: 9515964
author list: Ranger AM, Grusby MJ, Hodge MR, Gravallese EM, de la Brousse FC, Hoey T, Mickanin C, Baldwin HS, Glimcher LH
published in: Nature
information resource reference: The transcription factor NF-ATc is essential for cardiac valve formation. Nature. 1998 Mar 12; 392(6672):186-90.
journal title abbreviation: Nature
publication date: 1998-03-12T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

CD8+ effector cells responding to residual class I antigens, with help from CD4+ cells stimulated indirectly, cause rejection of "major histocompatibility complex-deficient" skin grafts.
PubMed Identifier: 9133474
author list: Lee RS, Grusby MJ, Laufer TM, Colvin R, Glimcher LH, Auchincloss H
published in: Transplantation
information resource reference: CD8+ effector cells responding to residual class I antigens, with help from CD4+ cells stimulated indirectly, cause rejection of "major histocompatibility complex-deficient" skin grafts. Transplantation. 1997 Apr 27; 63(8):1123-33.
journal title abbreviation: Transplantation
publication date: 1997-04-27T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity.
PubMed Identifier: 9326636
author list: Smiley ST, Boyer SN, Heeb MJ, Griffin JH, Grusby MJ
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Protein S is inducible by interleukin 4 in T cells and inhibits lymphoid cell procoagulant activity. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11484-9.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1997-10-14T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen.
PubMed Identifier: 16505356
author list: Huang H, Kearney JF, Grusby MJ, Benoist C, Mathis D
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen. Proc Natl Acad Sci U S A. 2006 Mar 07; 103(10):3734-9.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2006-02-27T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Marking IL-4-producing cells by knock-in of the IL-4 gene.
PubMed Identifier: 10069422
author list: Ho IC, Kaplan MH, Jackson-Grusby L, Glimcher LH, Grusby MJ
published in: International immunology
information resource reference: Marking IL-4-producing cells by knock-in of the IL-4 gene. Int Immunol. 1999 Feb; 11(2):243-7.
journal title abbreviation: Int Immunol
publication date: 1999-02-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity.
PubMed Identifier: 12669034
author list: Akbari O, Stock P, Meyer E, Kronenberg M, Sidobre S, Nakayama T, Taniguchi M, Grusby MJ, DeKruyff RH, Umetsu DT
published in: Nature medicine
information resource reference: Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med. 2003 May; 9(5):582-8.
journal title abbreviation: Nat Med
publication date: 2003-03-31T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource