JCC14JonClardyJon Clardy, Ph.D.42.33588600000000-71.1051460000000021956Clardy, JonC.617/432-2845Christopher T. Walsh, PhD Professor of Biological Chemistry and Molecular Pharmacologycatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson10464220Stohl EA, Brady SF, Clardy J, Handelsman JJournal of bacteriologyZmaR, a novel and widespread antibiotic resistance determinant that acetylates zwittermicin A. J Bacteriol. 1999 Sep; 181(17):5455-60.J Bacteriol1999-09-01T00:00:001999ZmaR, a novel and widespread antibiotic resistance determinant that acetylates zwittermicin A.Authorship 1048841629416082Silva-Junior EA, Ruzzini AC, Paludo CR, Nascimento FS, Currie CR, Clardy J, Pupo MTScientific reportsPyrazines from bacteria and ants: convergent chemistry within an ecological niche. Sci Rep. 2018 02 07; 8(1):2595.Sci Rep2018-02-07T00:00:002018Pyrazines from bacteria and ants: convergent chemistry within an ecological niche.10754679Li JY, Strobel G, Harper J, Lobkovsky E, Clardy JOrganic lettersCryptocin, a potent tetramic acid antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina. Org Lett. 2000 Mar 23; 2(6):767-70.Org Lett2000-03-23T00:00:002000Cryptocin, a potent tetramic acid antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina.10801859Das AK, Bellizzi JJ, Tandel S, Biehl E, Clardy J, Hofmann SLThe Journal of biological chemistryStructural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride. J Biol Chem. 2000 Aug 04; 275(31):23847-51.J Biol Chem2000-08-04T00:00:002000Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride.10814312Sutton AE, Clardy JOrganic lettersThe total synthesis of pantocin B. Org Lett. 2000 Feb 10; 2(3):319-21.Org Lett2000-02-10T00:00:002000The total synthesis of pantocin B.11112639Brady SF, Wagenaar MM, Singh MP, Janso JE, Clardy JOrganic lettersThe cytosporones, new octaketide antibiotics isolated from an endophytic fungus. Org Lett. 2000 Dec 14; 2(25):4043-6.Org Lett2000-12-14T00:00:002000The cytosporones, new octaketide antibiotics isolated from an endophytic fungus.12529120Brady SF, Clardy JOrganic lettersSynthesis of long-chain fatty acid enol esters isolated from an environmental DNA clone. Org Lett. 2003 Jan 23; 5(2):121-4.Org Lett2003-01-23T00:00:002003Synthesis of long-chain fatty acid enol esters isolated from an environmental DNA clone.Authorship 1028717Authorship 1051593429503481Ortega HE, Batista JM, Melo WGP, Clardy J, Pupo MTTetrahedron lettersAbsolute Configurations of Griseorhodins A and C. Tetrahedron Lett. 2017 12 13; 58(50):4721-4723.Tetrahedron Lett2017-11-07T00:00:002017Absolute Configurations of Griseorhodins A and C.4733808Büchi G, Kitaura Y, Yuan SS, Wright HE, Clardy J, Demain AL, Ginsukon T, Hunt N, Wogan GNJournal of the American Chemical SocietyLetter: structure of cytochalasin E, a toxic metabolite of Aspergillus clavatus. J Am Chem Soc. 1973 Aug 08; 95(16):5423-5.J Am Chem Soc1973-08-08T00:00:001973Letter: structure of cytochalasin E, a toxic metabolite of Aspergillus clavatus.4789148Hall SS, Faulkner DJ, Fayos J, Clardy JJournal of the American Chemical SocietyOppositol, a brominated sesquiterpene alcohol of a new skeletal class from the red alga, Laurencia subopposita. J Am Chem Soc. 1973 Oct 17; 95(21):7187-9.J Am Chem Soc1973-10-17T00:00:001973Oppositol, a brominated sesquiterpene alcohol of a new skeletal class from the red alga, Laurencia subopposita.2095376Ahmad VU, Choudhary MI, Akhtar MF, Ahmed M, Rizwani GH, Usmanghani K, Clardy JJournal of natural products2-O-alpha-D-galactopyranosyl glycerol hexaacetate from Ruellia brittoniana. J Nat Prod. 1990 Jul-Aug; 53(4):960-3.J Nat Prod1990-07-01T00:00:0019902-O-alpha-D-galactopyranosyl glycerol hexaacetate from Ruellia brittoniana.8662507Choi J, Chen J, Schreiber SL, Clardy JScience (New York, N.Y.)Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science. 1996 Jul 12; 273(5272):239-42.Science1996-07-12T00:00:001996Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.9383479Lee JC, Yang X, Schwartz M, Strobel G, Clardy JChemistry & biologyThe relationship between an endangered North American tree and an endophytic fungus. Chem Biol. 1995 Nov; 2(11):721-7.Chem Biol1995-11-01T00:00:001995The relationship between an endangered North American tree and an endophytic fungus.9871618Schultz LW, Clardy JBioorganic & medicinal chemistry lettersChemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12. Bioorg Med Chem Lett. 1998 Jan 06; 8(1):1-6.Bioorg Med Chem Lett1998-01-06T00:00:001998Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12.10819296Singh MP, Janso JE, Luckman SW, Brady SF, Clardy J, Greenstein M, Maiese WMThe Journal of antibioticsBiological activity of guanacastepene, a novel diterpenoid antibiotic produced by an unidentified fungus CR115. J Antibiot (Tokyo). 2000 Mar; 53(3):256-61.J Antibiot (Tokyo)2000-03-01T00:00:002000Biological activity of guanacastepene, a novel diterpenoid antibiotic produced by an unidentified fungus CR115.Authorship 104889519240153Hoekstra AV, Sefton EC, Berry E, Lu Z, Hardt J, Marsh E, Yin P, Clardy J, Chakravarti D, Bulun S, Kim JJThe Journal of clinical endocrinology and metabolismProgestins activate the AKT pathway in leiomyoma cells and promote survival. J Clin Endocrinol Metab. 2009 May; 94(5):1768-74.J Clin Endocrinol Metab2009-02-24T00:00:002009Progestins activate the AKT pathway in leiomyoma cells and promote survival.19330011Oh DC, Poulsen M, Currie CR, Clardy JNature chemical biologyDentigerumycin: a bacterial mediator of an ant-fungus symbiosis. Nat Chem Biol. 2009 Jun; 5(6):391-3.Nat Chem Biol2009-03-29T00:00:002009Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis.19807062Hollenhorst MA, Clardy J, Walsh CTBiochemistryThe ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics. Biochemistry. 2009 Nov 03; 48(43):10467-72.Biochemistry2009-11-03T00:00:002009The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics.Authorship 1059738329678921Böttcher T, Szamosvári D, Clardy JApplied and environmental microbiologyA Repeating Sulfated Galactan Motif Resuscitates Dormant Micrococcus luteus Bacteria. Appl Environ Microbiol. 2018 07 01; 84(13).Appl Environ Microbiol2018-06-18T00:00:002018A Repeating Sulfated Galactan Motif Resuscitates Dormant Micrococcus luteus Bacteria.18791072Butcher RA, Ragains JR, Kim E, Clardy JProceedings of the National Academy of Sciences of the United States of AmericaA potent dauer pheromone component in Caenorhabditis elegans that acts synergistically with other components. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14288-92.Proc Natl Acad Sci U S A2008-09-12T00:00:002008A potent dauer pheromone component in Caenorhabditis elegans that acts synergistically with other components.19041124Berry E, Hardt JL, Clardy J, Lurain JR, Kim JJGynecologic oncologyInduction of apoptosis in endometrial cancer cells by psammaplysene A involves FOXO1. Gynecol Oncol. 2009 Feb; 112(2):331-6.Gynecol Oncol2008-11-28T00:00:002008Induction of apoptosis in endometrial cancer cells by psammaplysene A involves FOXO1.Authorship 1060616529700993Ganley JG, Carr G, Ioerger TR, Sacchettini JC, Clardy J, Derbyshire ERChembiochem : a European journal of chemical biologyDiscovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes. Chembiochem. 2018 08 06; 19(15):1590-1594.Chembiochem2018-06-10T00:00:002018Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes.21247188Oh DC, Poulsen M, Currie CR, Clardy JOrganic lettersSceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp. Org Lett. 2011 Feb 18; 13(4):752-5.Org Lett2011-01-19T00:00:002011Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp.21615115Carr G, Seyedsayamdost MR, Chandler JR, Greenberg EP, Clardy JOrganic lettersSources of diversity in bactobolin biosynthesis by Burkholderia thailandensis E264. Org Lett. 2011 Jun 17; 13(12):3048-51.Org Lett2011-05-26T00:00:002011Sources of diversity in bactobolin biosynthesis by Burkholderia thailandensis E264.22359585Ymele-Leki P, Cao S, Sharp J, Lambert KG, McAdam AJ, Husson RN, Tamayo G, Clardy J, Watnick PIPloS oneA high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity. PLoS One. 2012; 7(2):e31307.PLoS One2012-02-16T00:00:002012A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity.4414411Fayos J, Lokensgard D, Clardy J, Cole RJ, Kirksey JWJournal of the American Chemical SocietyLetter: Structure of verruculogen, a tremor producing peroxide from Penicillium verruculosum. J Am Chem Soc. 1974 Oct 16; 96(21):6785-7.J Am Chem Soc1974-10-16T00:00:001974Letter: Structure of verruculogen, a tremor producing peroxide from Penicillium verruculosum.4853623Swenton JS, Hyatt JA, Lisy JM, Clardy JJournal of the American Chemical SocietyPhotochemical cycloadditions of triplet 1,3-dimethyluracil to olefins. Structural studies on the adducts. J Am Chem Soc. 1974 Jul 24; 96(15):4885-91.J Am Chem Soc1974-07-24T00:00:001974Photochemical cycloadditions of triplet 1,3-dimethyluracil to olefins. Structural studies on the adducts.7678431Van Duyne GD, Standaert RF, Karplus PA, Schreiber SL, Clardy JJournal of molecular biologyAtomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin. J Mol Biol. 1993 Jan 05; 229(1):105-24.J Mol Biol1993-01-05T00:00:001993Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin.19196969Wieland Brown LC, Acker MG, Clardy J, Walsh CT, Fischbach MAProceedings of the National Academy of Sciences of the United States of AmericaThirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2549-53.Proc Natl Acad Sci U S A2009-02-05T00:00:002009Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin.Authorship 10697981029844859Sun B, Wang G, Liu H, Liu P, Twal WO, Cheung H, Carroll SL, Ethier SP, Mevers EE, Clardy J, Roberts T, Chen C, Li Q, Wang L, Yang M, Zhao JJ, Wang QOncotargetOridonin inhibits aberrant AKT activation in breast cancer. Oncotarget. 2018 May 08; 9(35):23878-23889.Oncotarget2018-02-01T00:00:002018Oridonin inhibits aberrant AKT activation in breast cancer.21430694Seyedsayamdost MR, Case RJ, Kolter R, Clardy JNature chemistryThe Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis. Nat Chem. 2011 Apr; 3(4):331-5.Nat Chem2011-02-27T00:00:002011The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis.21966266Derbyshire ER, Mota MM, Clardy JPLoS pathogensThe next opportunity in anti-malaria drug discovery: the liver stage. PLoS Pathog. 2011 Sep; 7(9):e1002178.PLoS Pathog2011-09-22T00:00:002011The next opportunity in anti-malaria drug discovery: the liver stage.23066504Alegado RA, Brown LW, Cao S, Dermenjian RK, Zuzow R, Fairclough SR, Clardy J, King NeLifeA bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals. Elife. 2012 Oct 15; 1:e00013.Elife2012-10-15T00:00:002012A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals.15051880Chen H, Fujita M, Feng Q, Clardy J, Fink GRProceedings of the National Academy of Sciences of the United States of AmericaTyrosol is a quorum-sensing molecule in Candida albicans. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):5048-52.Proc Natl Acad Sci U S A2004-03-29T00:00:002004Tyrosol is a quorum-sensing molecule in Candida albicans.16092832Brady SF, Clardy JOrganic lettersN-acyl derivatives of arginine and tryptophan isolated from environmental DNA expressed in Escherichia coli. Org Lett. 2005 Aug 18; 7(17):3613-6.Org Lett2005-08-18T00:00:002005N-acyl derivatives of arginine and tryptophan isolated from environmental DNA expressed in Escherichia coli.16206308Brady SF, Clardy JAngewandte Chemie (International ed. in English)Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA. Angew Chem Int Ed Engl. 2005 Nov 04; 44(43):7063-5.Angew Chem Int Ed Engl2005-11-04T00:00:002005Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA.Authorship 1068071Authorship 1075578429931794Spady ES, Wyche TP, Rollins NJ, Clardy J, Way JC, Silver PAChembiochem : a European journal of chemical biologyMammalian Cells Engineered To Produce New Steroids. Chembiochem. 2018 09 04; 19(17):1827-1833.Chembiochem2018-07-26T00:00:002018Mammalian Cells Engineered To Produce New Steroids.20626288Schloss PD, Allen HK, Klimowicz AK, Mlot C, Gross JA, Savengsuksa S, McEllin J, Clardy J, Ruess RW, Handelsman JDNA and cell biologyPsychrotrophic strain of Janthinobacterium lividum from a cold Alaskan soil produces prodigiosin. DNA Cell Biol. 2010 Sep; 29(9):533-41.DNA Cell Biol2010-09-01T00:00:002010Psychrotrophic strain of Janthinobacterium lividum from a cold Alaskan soil produces prodigiosin.23084935Seyedsayamdost MR, Traxler MF, Clardy J, Kolter RMethods in enzymologyOld meets new: using interspecies interactions to detect secondary metabolite production in actinomycetes. Methods Enzymol. 2012; 517:89-109.Methods Enzymol2012-01-01T00:00:002012Old meets new: using interspecies interactions to detect secondary metabolite production in actinomycetes.21928816Seyedsayamdost MR, Carr G, Kolter R, Clardy JJournal of the American Chemical SocietyRoseobacticides: small molecule modulators of an algal-bacterial symbiosis. J Am Chem Soc. 2011 Nov 16; 133(45):18343-9.J Am Chem Soc2011-10-24T00:00:002011Roseobacticides: small molecule modulators of an algal-bacterial symbiosis.22283276Wilcox CF, Blain DA, Clardy J, Van Duyne G, Gleiter R, Eckert-Maksic MJournal of the American Chemical Society3H-Cyclonona[def]biphenylene. An example of neutral homoantiaromaticity. J Am Chem Soc. 1986 Nov 01; 108(24):7693-702.J Am Chem Soc1986-11-01T00:00:0019863H-Cyclonona[def]biphenylene. An example of neutral homoantiaromaticity.18852127Fernández de Mattos S, Villalonga P, Clardy J, Lam EWMolecular cancer therapeuticsFOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells. Mol Cancer Ther. 2008 Oct; 7(10):3237-46.Mol Cancer Ther2008-10-01T00:00:002008FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells.20547882Blodgett JA, Oh DC, Cao S, Currie CR, Kolter R, Clardy JProceedings of the National Academy of Sciences of the United States of AmericaCommon biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria. Proc Natl Acad Sci U S A. 2010 Jun 29; 107(26):11692-7.Proc Natl Acad Sci U S A2010-06-14T00:00:002010Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria.22175476Shimizu Y, Chou HN, Bando H, Van Duyne G, Clardy JJournal of the American Chemical SocietyStructure of brevetoxin A (GB-1 toxin), the most potent toxin in the Florida red tide organism Gymnodinium breve (Ptychodiscus brevis). J Am Chem Soc. 1986 Feb 01; 108(3):514-5.J Am Chem Soc1986-02-01T00:00:001986Structure of brevetoxin A (GB-1 toxin), the most potent toxin in the Florida red tide organism Gymnodinium breve (Ptychodiscus brevis).3866223Sugawara F, Strobel G, Fisher LE, Van Duyne GD, Clardy JProceedings of the National Academy of Sciences of the United States of AmericaBipolaroxin, a selective phytotoxin produced by Bipolaris cynodontis. Proc Natl Acad Sci U S A. 1985 Dec; 82(24):8291-4.Proc Natl Acad Sci U S A1985-12-01T00:00:001985Bipolaroxin, a selective phytotoxin produced by Bipolaris cynodontis.7592067Kirst HA, Larsen SH, Paschal JW, Occolowitz JL, Creemer LC, Steiner JL, Lobkovsky E, Clardy JThe Journal of antibioticsStructure of the new spiroketal-macrolide A82548A. J Antibiot (Tokyo). 1995 Sep; 48(9):990-6.J Antibiot (Tokyo)1995-09-01T00:00:001995Structure of the new spiroketal-macrolide A82548A.4833647Springer JP, Clardy J, Cole RJ, Kirksey JW, Hill RK, Carlson MR, Isidor JLJournal of the American Chemical SocietyStructure and synthesis of moniliformin, a novel cyclobutane microbial toxin. J Am Chem Soc. 1974 Apr 03; 96(7):2267-8.J Am Chem Soc1974-04-03T00:00:001974Structure and synthesis of moniliformin, a novel cyclobutane microbial toxin.19515346Clardy J, Fischbach MA, Currie CRCurrent biology : CBThe natural history of antibiotics. Curr Biol. 2009 Jun 09; 19(11):R437-41.Curr Biol2009-06-09T00:00:002009The natural history of antibiotics.7689808Clardy JAnnals of the New York Academy of SciencesStructural studies of complexed FK-506 binding protein. Ann N Y Acad Sci. 1993 Jun 23; 685:37-45.Ann N Y Acad Sci1993-06-23T00:00:001993Structural studies of complexed FK-506 binding protein.18832638Scott JJ, Oh DC, Yuceer MC, Klepzig KD, Clardy J, Currie CRScience (New York, N.Y.)Bacterial protection of beetle-fungus mutualism. Science. 2008 Oct 03; 322(5898):63.Science2008-10-03T00:00:002008Bacterial protection of beetle-fungus mutualism.20041686Blasiak LC, Clardy JJournal of the American Chemical SocietyDiscovery of 3-formyl-tyrosine metabolites from Pseudoalteromonas tunicata through heterologous expression. J Am Chem Soc. 2010 Jan 27; 132(3):926-7.J Am Chem Soc2010-01-27T00:00:002010Discovery of 3-formyl-tyrosine metabolites from Pseudoalteromonas tunicata through heterologous expression.20839869Cao S, Ross L, Tamayo G, Clardy JOrganic lettersAsterogynins: secondary metabolites from a Costa Rican endophytic fungus. Org Lett. 2010 Oct 15; 12(20):4661-3.Org Lett2010-10-15T00:00:002010Asterogynins: secondary metabolites from a Costa Rican endophytic fungus.22438279Derbyshire ER, Mazitschek R, Clardy JChemMedChemCharacterization of Plasmodium liver stage inhibition by halofuginone. ChemMedChem. 2012 May; 7(5):844-9.ChemMedChem2012-03-21T00:00:002012Characterization of Plasmodium liver stage inhibition by halofuginone.22541437Kolodkin-Gal I, Cao S, Chai L, Böttcher T, Kolter R, Clardy J, Losick RCellA self-produced trigger for biofilm disassembly that targets exopolysaccharide. Cell. 2012 Apr 27; 149(3):684-92.Cell2012-04-27T00:00:002012A self-produced trigger for biofilm disassembly that targets exopolysaccharide.Authorship 1091880630190434Coutinho BG, Mevers E, Schaefer AL, Pelletier DA, Harwood CS, Clardy J, Greenberg EPProceedings of the National Academy of Sciences of the United States of AmericaA plant-responsive bacterial-signaling system senses an ethanolamine derivative. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):9785-9790.Proc Natl Acad Sci U S A2018-09-06T00:00:002018A plant-responsive bacterial-signaling system senses an ethanolamine derivative.7420351Grieco PA, Owens W, Wang CL, Williams E, Schillinger WJ, Hirotsu K, Clardy JJournal of medicinal chemistryFluoroprostaglandins: synthesis and biological evaluation of the methyl esters of (+)-12-fluoro-, (-)-ent-12-fluoro-, (+)-15-epi-fluoro-, and (-)-ent-15 epi-12-fluoroprostaglandin F2 alpha. J Med Chem. 1980 Oct; 23(10):1072-7.J Med Chem1980-10-01T00:00:001980Fluoroprostaglandins: synthesis and biological evaluation of the methyl esters of (+)-12-fluoro-, (-)-ent-12-fluoro-, (+)-15-epi-fluoro-, and (-)-ent-15 epi-12-fluoroprostaglandin F2 alpha.8254352Miles DH, Tunsuwan K, Chittawong V, Hedin PA, Kokpol U, Ni CZ, Clardy JJournal of natural productsAgrochemical activity and isolation of N-(4'-bromophenyl)-2,2-diphenylacetanilide from the Thai plant Arundo donax. J Nat Prod. 1993 Sep; 56(9):1590-3.J Nat Prod1993-09-01T00:00:001993Agrochemical activity and isolation of N-(4'-bromophenyl)-2,2-diphenylacetanilide from the Thai plant Arundo donax.2778451Lin LZ, Cordell GA, Ni CZ, Clardy JJournal of natural productsNew humantenine-type alkaloids from Gelsemium elegans. J Nat Prod. 1989 May-Jun; 52(3):588-94.J Nat Prod1989-05-01T00:00:001989New humantenine-type alkaloids from Gelsemium elegans.22711807Crawford JM, Portmann C, Zhang X, Roeffaers MB, Clardy JProceedings of the National Academy of Sciences of the United States of AmericaSmall molecule perimeter defense in entomopathogenic bacteria. Proc Natl Acad Sci U S A. 2012 Jul 03; 109(27):10821-6.Proc Natl Acad Sci U S A2012-06-18T00:00:002012Small molecule perimeter defense in entomopathogenic bacteria.18630919Kontnik R, Bosak T, Butcher RA, Brocks JJ, Losick R, Clardy J, Pearson AOrganic lettersSporulenes, heptaprenyl metabolites from Bacillus subtilis spores. Org Lett. 2008 Aug 21; 10(16):3551-4.Org Lett2008-07-17T00:00:002008Sporulenes, heptaprenyl metabolites from Bacillus subtilis spores.19125624Oh DC, Scott JJ, Currie CR, Clardy JOrganic lettersMycangimycin, a polyene peroxide from a mutualist Streptomyces sp. Org Lett. 2009 Feb 05; 11(3):633-6.Org Lett2009-02-05T00:00:002009Mycangimycin, a polyene peroxide from a mutualist Streptomyces sp.19762646Lam H, Oh DC, Cava F, Takacs CN, Clardy J, de Pedro MA, Waldor MKScience (New York, N.Y.)D-amino acids govern stationary phase cell wall remodeling in bacteria. Science. 2009 Sep 18; 325(5947):1552-5.Science2009-09-18T00:00:002009D-amino acids govern stationary phase cell wall remodeling in bacteria.20041689Dawlaty J, Zhang X, Fischbach MA, Clardy JJournal of natural productsDapdiamides, tripeptide antibiotics formed by unconventional amide ligases. J Nat Prod. 2010 Mar 26; 73(3):441-6.J Nat Prod2010-03-26T00:00:002010Dapdiamides, tripeptide antibiotics formed by unconventional amide ligases.Authorship 1093081930228116Pishchany G, Mevers E, Ndousse-Fetter S, Horvath DJ, Paludo CR, Silva-Junior EA, Koren S, Skaar EP, Clardy J, Kolter RProceedings of the National Academy of Sciences of the United States of AmericaAmycomicin is a potent and specific antibiotic discovered with a targeted interaction screen. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):10124-10129.Proc Natl Acad Sci U S A2018-09-18T00:00:002018Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen.22910038Cao S, Cryan L, Habeshian KA, Murillo C, Tamayo-Castillo G, Rogers MS, Clardy JBioorganic & medicinal chemistry lettersPhenolic compounds as antiangiogenic CMG2 inhibitors from Costa Rican endophytic fungi. Bioorg Med Chem Lett. 2012 Sep 15; 22(18):5885-8.Bioorg Med Chem Lett2012-08-03T00:00:002012Phenolic compounds as antiangiogenic CMG2 inhibitors from Costa Rican endophytic fungi.Authorship 1325221523165928Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WANatural product reportsRibosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep. 2013 Jan; 30(1):108-60.Nat Prod Rep2013-01-01T00:00:002013Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.3404156Mikolajczak KL, Weisleder D, Parkanyi L, Clardy JJournal of natural productsA limonoid antifeedant from seed of Carapa procera. J Nat Prod. 1988 May-Jun; 51(3):606-10.J Nat Prod1988-05-01T00:00:001988A limonoid antifeedant from seed of Carapa procera.Authorship 1096259530282739Li H, Sosa-Calvo J, Horn HA, Pupo MT, Clardy J, Rabeling C, Schultz TR, Currie CRProceedings of the National Academy of Sciences of the United States of AmericaConvergent evolution of complex structures for ant-bacterial defensive symbiosis in fungus-farming ants. Proc Natl Acad Sci U S A. 2018 10 16; 115(42):10720-10725.Proc Natl Acad Sci U S A2018-10-03T00:00:002018Convergent evolution of complex structures for ant-bacterial defensive symbiosis in fungus-farming ants.17163634Clardy JACS chemical biologyStopping trouble before it starts. ACS Chem Biol. 2006 Feb 17; 1(1):17-9.ACS Chem Biol2006-02-17T00:00:002006Stopping trouble before it starts.8031096Silo-Suh LA, Lethbridge BJ, Raffel SJ, He H, Clardy J, Handelsman JApplied and environmental microbiologyBiological activities of two fungistatic antibiotics produced by Bacillus cereus UW85. Appl Environ Microbiol. 1994 Jun; 60(6):2023-30.Appl Environ Microbiol1994-06-01T00:00:001994Biological activities of two fungistatic antibiotics produced by Bacillus cereus UW85.1176733Pezzanite JO, Clardy J, Lau PY, Wood G, Walker DL, Fraser-Reid BJournal of the American Chemical SocietyLetter: A revised structure for the antibiotic pillaromycin A. J Am Chem Soc. 1975 Oct 15; 97(21):6250-1.J Am Chem Soc1975-10-15T00:00:001975Letter: A revised structure for the antibiotic pillaromycin A.Authorship 1090282Authorship 112925418993067Martyn DC, Ramirez AP, Beattie MJ, Cortese JF, Patel V, Rush MA, Woerpel KA, Clardy JBioorganic & medicinal chemistry lettersSynthesis of spiro-1,2-dioxolanes and their activity against Plasmodium falciparum. Bioorg Med Chem Lett. 2008 Dec 15; 18(24):6521-4.Bioorg Med Chem Lett2008-11-01T00:00:002008Synthesis of spiro-1,2-dioxolanes and their activity against Plasmodium falciparum.2661511Nishio M, Tomatsu K, Konishi M, Tomita K, Oki T, Kawaguchi H, Clardy JThe Journal of antibioticsKarnamicin, a complex of new antifungal antibiotics. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties. J Antibiot (Tokyo). 1989 Jun; 42(6):852-68.J Antibiot (Tokyo)1989-06-01T00:00:001989Karnamicin, a complex of new antifungal antibiotics. I. Taxonomy, fermentation, isolation and physico-chemical and biological properties.20843016Cao S, Blodgett JA, Clardy JOrganic lettersTargeted discovery of polycyclic tetramate macrolactams from an environmental Streptomyces strain. Org Lett. 2010 Oct 15; 12(20):4652-4.Org Lett2010-10-15T00:00:002010Targeted discovery of polycyclic tetramate macrolactams from an environmental Streptomyces strain.22830960Seyedsayamdost MR, Cleto S, Carr G, Vlamakis H, João Vieira M, Kolter R, Clardy JJournal of the American Chemical SocietyMixing and matching siderophore clusters: structure and biosynthesis of serratiochelins from Serratia sp. V4. J Am Chem Soc. 2012 Aug 22; 134(33):13550-3.J Am Chem Soc2012-08-13T00:00:002012Mixing and matching siderophore clusters: structure and biosynthesis of serratiochelins from Serratia sp. V4.23209822Harris ES, Cao S, Schoville SD, Dong C, Wang W, Jian Z, Zhao Z, Eisenberg DM, Clardy JPloS oneSelection for high oridonin yield in the Chinese medicinal plant Isodon (Lamiaceae) using a combined phylogenetics and population genetics approach. PLoS One. 2012; 7(11):e50753.PLoS One2012-11-27T00:00:002012Selection for high oridonin yield in the Chinese medicinal plant Isodon (Lamiaceae) using a combined phylogenetics and population genetics approach.10196127Odagaki Y, Hayashi A, Okada K, Hirotsu K, Kabashima T, Ito K, Yoshimoto T, Tsuru D, Sato M, Clardy JStructure (London, England : 1993)The crystal structure of pyroglutamyl peptidase I from Bacillus amyloliquefaciens reveals a new structure for a cysteine protease. Structure. 1999 Apr 15; 7(4):399-411.Structure1999-04-15T00:00:001999The crystal structure of pyroglutamyl peptidase I from Bacillus amyloliquefaciens reveals a new structure for a cysteine protease.10662696Sandler BH, Nikonova L, Leal WS, Clardy JChemistry & biologySexual attraction in the silkworm moth: structure of the pheromone-binding-protein-bombykol complex. Chem Biol. 2000 Feb; 7(2):143-51.Chem Biol2000-02-01T00:00:002000Sexual attraction in the silkworm moth: structure of the pheromone-binding-protein-bombykol complex.Authorship 13303737344705Balitz DM, O'Herron FA, Bush J, Vyas DM, Nettleton DE, Grulich RE, Bradner WT, Doyle TW, Arnold E, Clardy JThe Journal of antibioticsAntitumor agents from Streptomyces anandii: gilvocarcins V, M and E. J Antibiot (Tokyo). 1981 Dec; 34(12):1544-55.J Antibiot (Tokyo)1981-12-01T00:00:001981Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E.11314967Qiu SX, Nguyen VH, Le TX, Gu JQ, Lobkovsky E, Tran CK, Soejarto DD, Clardy J, Pezzuto JM, Dong Y, Mai VT, Le MH, Fong HHPhytochemistryA pregnane steroid from Aglaia lawii and structure confirmation of cabraleadiol monoacetate by X-ray crystallography. Phytochemistry. 2001 Apr; 56(7):775-80.Phytochemistry2001-04-01T00:00:002001A pregnane steroid from Aglaia lawii and structure confirmation of cabraleadiol monoacetate by X-ray crystallography.11867708Liu S, Cerione RA, Clardy JProceedings of the National Academy of Sciences of the United States of AmericaStructural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2743-7.Proc Natl Acad Sci U S A2002-02-26T00:00:002002Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity.11869098Wagenaar MM, Gibson DM, Clardy JOrganic lettersAkanthomycin, a new antibiotic pyridone from the entomopathogenic fungus Akanthomyces gracilis. Org Lett. 2002 Mar 07; 4(5):671-3.Org Lett2002-03-07T00:00:002002Akanthomycin, a new antibiotic pyridone from the entomopathogenic fungus Akanthomyces gracilis.12200279Gillespie DE, Brady SF, Bettermann AD, Cianciotto NP, Liles MR, Rondon MR, Clardy J, Goodman RM, Handelsman JApplied and environmental microbiologyIsolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA. Appl Environ Microbiol. 2002 Sep; 68(9):4301-6.Appl Environ Microbiol2002-09-01T00:00:002002Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA.12492342Thale Z, Johnson T, Tenney K, Wenzel PJ, Lobkovsky E, Clardy J, Media J, Pietraszkiewicz H, Valeriote FA, Crews PThe Journal of organic chemistryStructures and cytotoxic properties of sponge-derived bisannulated acridines. J Org Chem. 2002 Dec 27; 67(26):9384-91.J Org Chem2002-12-27T00:00:002002Structures and cytotoxic properties of sponge-derived bisannulated acridines.972231Chexal KK, Spinger JP, Clardy J, Cole RJ, Kirksey JW, Dorner JW, Cutler HG, Strawter BJJournal of the American Chemical SocietyAustin, a novel polyisoprenoid mycotoxin from Aspergillus ustus. J Am Chem Soc. 1976 Oct 13; 98(21):6748.J Am Chem Soc1976-10-13T00:00:001976Austin, a novel polyisoprenoid mycotoxin from Aspergillus ustus.1244370Macmillan JG, Springer JP, Clardy J, Cole RJ, Kirksey JWJournal of the American Chemical SocietyLetter: Structure and synthesis of verruculotoxin, a new mycotoxin from Penicillium verruculosum Peyronel. J Am Chem Soc. 1976 Jan 07; 98(1):246-7.J Am Chem Soc1976-01-07T00:00:001976Letter: Structure and synthesis of verruculotoxin, a new mycotoxin from Penicillium verruculosum Peyronel.16899456Smith PL, Maloney KN, Pothen RG, Clardy J, Clapham DEThe Journal of biological chemistryBisandrographolide from Andrographis paniculata activates TRPV4 channels. J Biol Chem. 2006 Oct 06; 281(40):29897-904.J Biol Chem2006-08-09T00:00:002006Bisandrographolide from Andrographis paniculata activates TRPV4 channels.Authorship 1238041017558398Butcher RA, Fujita M, Schroeder FC, Clardy JNature chemical biologySmall-molecule pheromones that control dauer development in Caenorhabditis elegans. Nat Chem Biol. 2007 Jul; 3(7):420-2.Nat Chem Biol2007-06-10T00:00:002007Small-molecule pheromones that control dauer development in Caenorhabditis elegans.18959442Maloney KN, Fujita M, Eggert US, Schroeder FC, Field CM, Mitchison TJ, Clardy JJournal of natural productsActin-aggregating cucurbitacins from Physocarpus capitatus. J Nat Prod. 2008 Nov; 71(11):1927-9.J Nat Prod2008-10-29T00:00:002008Actin-aggregating cucurbitacins from Physocarpus capitatus.19545143Butcher RA, Ragains JR, Clardy JOrganic lettersAn indole-containing dauer pheromone component with unusual dauer inhibitory activity at higher concentrations. Org Lett. 2009 Jul 16; 11(14):3100-3.Org Lett2009-07-16T00:00:002009An indole-containing dauer pheromone component with unusual dauer inhibitory activity at higher concentrations.20095633Seyedsayamdost MR, Chandler JR, Blodgett JA, Lima PS, Duerkop BA, Oinuma K, Greenberg EP, Clardy JOrganic lettersQuorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264. Org Lett. 2010 Feb 19; 12(4):716-9.Org Lett2010-02-19T00:00:002010Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264.22550177Crawford JM, Clardy JProceedings of the National Academy of Sciences of the United States of AmericaMicrobial genome mining answers longstanding biosynthetic questions. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7589-90.Proc Natl Acad Sci U S A2012-05-01T00:00:002012Microbial genome mining answers longstanding biosynthetic questions.Authorship 112065818Authorship 11211452Authorship 1119811430531975Strandwitz P, Kim KH, Terekhova D, Liu JK, Sharma A, Levering J, McDonald D, Dietrich D, Ramadhar TR, Lekbua A, Mroue N, Liston C, Stewart EJ, Dubin MJ, Zengler K, Knight R, Gilbert JA, Clardy J, Lewis KNature microbiologyGABA-modulating bacteria of the human gut microbiota. Nat Microbiol. 2019 03; 4(3):396-403.Nat Microbiol2018-12-10T00:00:002018GABA-modulating bacteria of the human gut microbiota.30559356Brown A, Clardy JNatureTiny crystals have big potential for determining structures of small molecules. Nature. 2018 12; 564(7736):348-349.Nature2018-12-01T00:00:002018Tiny crystals have big potential for determining structures of small molecules.30576339Liao J, Xu G, Mevers EE, Clardy J, Watnick PIPloS oneA high-throughput, whole cell assay to identify compounds active against carbapenem-resistant Klebsiella pneumoniae. PLoS One. 2018; 13(12):e0209389.PLoS One2018-12-21T00:00:002018A high-throughput, whole cell assay to identify compounds active against carbapenem-resistant Klebsiella pneumoniae.22974996Stallforth P, Clardy JCurrent biology : CBProtein evolution: when two become three. Curr Biol. 2012 Sep 11; 22(17):R685-7.Curr Biol2012-09-11T00:00:002012Protein evolution: when two become three.Authorship 111871310426949Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy JNature structural biologyStructure of the PIN/LC8 dimer with a bound peptide. Nat Struct Biol. 1999 Aug; 6(8):735-40.Nat Struct Biol1999-08-01T00:00:001999Structure of the PIN/LC8 dimer with a bound peptide.10975659Bittinger MA, Gross JA, Widom J, Clardy J, Handelsman JMolecular plant-microbe interactions : MPMIRhizobium etli CE3 carries vir gene homologs on a self-transmissible plasmid. Mol Plant Microbe Interact. 2000 Sep; 13(9):1019-21.Mol Plant Microbe Interact2000-09-01T00:00:002000Rhizobium etli CE3 carries vir gene homologs on a self-transmissible plasmid.12833354Jin M, Wright SA, Beer SV, Clardy JAngewandte Chemie (International ed. in English)The biosynthetic gene cluster of Pantocin a provides insights into biosynthesis and a tool for screening. Angew Chem Int Ed Engl. 2003 Jun 30; 42(25):2902-5.Angew Chem Int Ed Engl2003-06-30T00:00:002003The biosynthetic gene cluster of Pantocin a provides insights into biosynthesis and a tool for screening.14706338Kau TR, Schroeder F, Ramaswamy S, Wojciechowski CL, Zhao JJ, Roberts TM, Clardy J, Sellers WR, Silver PACancer cellA chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell. 2003 Dec; 4(6):463-76.Cancer Cell2003-12-01T00:00:002003A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells.17116676Baniecki ML, Wirth DF, Clardy JAntimicrobial agents and chemotherapyHigh-throughput Plasmodium falciparum growth assay for malaria drug discovery. Antimicrob Agents Chemother. 2007 Feb; 51(2):716-23.Antimicrob Agents Chemother2006-11-20T00:00:002006High-throughput Plasmodium falciparum growth assay for malaria drug discovery.17234808Butcher RA, Schroeder FC, Fischbach MA, Straight PD, Kolter R, Walsh CT, Clardy JProceedings of the National Academy of Sciences of the United States of AmericaThe identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis. Proc Natl Acad Sci U S A. 2007 Jan 30; 104(5):1506-9.Proc Natl Acad Sci U S A2007-01-18T00:00:002007The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis.Authorship 11252183430648156Kearney SE, Zahoránszky-Kohalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JMACS central scienceCanvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. ACS Cent Sci. 2018 Dec 26; 4(12):1727-1741.ACS Cent Sci2018-12-05T00:00:002018Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.2707379Kernan MR, Faulkner DJ, Parkanyi L, Clardy J, de Carvalho MS, Jacobs RSExperientiaLuffolide, a novel anti-inflammatory terpene from the sponge Luffariella sp.. Experientia. 1989 Apr 15; 45(4):388-90.Experientia1989-04-15T00:00:001989Luffolide, a novel anti-inflammatory terpene from the sponge Luffariella sp..20929849Yamada K, Hirotsu T, Matsuki M, Butcher RA, Tomioka M, Ishihara T, Clardy J, Kunitomo H, Iino YScience (New York, N.Y.)Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans. Science. 2010 Sep 24; 329(5999):1647-50.Science2010-09-24T00:00:002010Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans.22050377Santagata S, Xu YM, Wijeratne EM, Kontnik R, Rooney C, Perley CC, Kwon H, Clardy J, Kesari S, Whitesell L, Lindquist S, Gunatilaka AAACS chemical biologyUsing the heat-shock response to discover anticancer compounds that target protein homeostasis. ACS Chem Biol. 2012 Feb 17; 7(2):340-9.ACS Chem Biol2011-11-30T00:00:002011Using the heat-shock response to discover anticancer compounds that target protein homeostasis.Authorship 11364951530833338Rollins-Smith LA, Ruzzini AC, Fites JS, Reinert LK, Hall EM, Joosse BA, Ravikumar VI, Huebner MI, Aka A, Kehs MH, Gillard BM, Doe E, Tasca JA, Umile TP, Clardy J, Minbiole KPCInfection and immunityMetabolites Involved in Immune Evasion by Batrachochytrium dendrobatidis Include the Polyamine Spermidine. Infect Immun. 2019 03; 87(5).Infect Immun2019-04-23T00:00:002019Metabolites Involved in Immune Evasion by Batrachochytrium dendrobatidis Include the Polyamine Spermidine.D005658Living Beings1913270.783187FungiD039903Living Beings32560.941428ActinobacteriaD015394Genes & Molecular Sequences81119250.693517Molecular StructureAuthorship 1226875D013302Living Beings51940.938413StreptomycesD013559Phenomena1272850.800618SymbiosisEmeritusImmunology and Infectious DiseasesMalaria/WirthMedicineRadiologyWyss InstituteGastroenterologyHarvard Medical SchoolHarvard T.H. Chan School of Public HealthHarvard UniversityMassachusetts General HospitalRX1RamnikXavierRamnik Xavier, M.B.,B.Ch.42.36125700000000-71.0655270000000064506Xavier, RamnikKurt J. Isselbacher Professor of Medicine in the Field of GastroenterologyGJH3GregoryHeffronGregory J. Heffron, B.S.42.33588600000000-71.1051460000000066752Heffron, GregoryDirector, HMS Bio-NMR CoreDFW3DyannWirthDyann Fergus Wirth, Ph.D.42.33547570000000-71.1014834000000053759Wirth, DyannRichard Pearson Strong Professor of Infectious DiseasesZL23ZongliLiZongli Li, Ph.D.42.33588600000000-71.1051460000000084770Li, ZongliLecturer on Biological Chemistry and Molecular PharmacologySB3StephenBuratowskiStephen Buratowski, Ph.D.42.33588600000000-71.1051460000000029782Buratowski, StephenHamilton Kuhn Professor of Biological Chemistry and Molecular PharmacologyRM65RalphMazitschekRalph Mazitschek, Ph.D.42.36272860000000-71.0843313000000064094Mazitschek, RalphAssistant Professor of RadiologyEAE1ElaineElionElaine A. Elion, Ph.D.42.33588600000000-71.1051460000000036031Elion, ElaineProfessor of Biological Chemistry and Molecular Pharmacology11372selected publications5.278890.001790781108research areas1.97070.015284866coauthor of91.004123.82260similar toRGK2RobertoKolterRoberto Guillermo Kolter, Ph.D.42.33594500000000-71.1029580000000041002Kolter, RobertoProfessor of Microbiology and Immunobiology, EmeritusJJC4JamesCollinsJames J. Collins, Ph.D.42.33594500000000-71.1029580000000055767Collins, JamesVisiting Professor of Systems Biology in the Wyss InstituteAuthorship 1161809631182571Henke MT, Kenny DJ, Cassilly CD, Vlamakis H, Xavier RJ, Clardy JProceedings of the National Academy of Sciences of the United States of AmericaRuminococcus gnavus, a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide. Proc Natl Acad Sci U S A. 2019 06 25; 116(26):12672-12677.Proc Natl Acad Sci U S A2019-06-10T00:00:002019Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide.AFC3AlanCowmanAlan F. Cowman, Ph.D.42.33547570000000-71.1014834000000052396Cowman, AlanVisiting ScientistWWB1WelcomeBenderWelcome W. Bender, Ph.D.42.33588600000000-71.1051460000000015697Bender, WelcomeHarold T. White Professor of Biological Chemistry and Molecular PharmacologyAuthorship 1248213Authorship 1165200931232690Mevers E, Su L, Pishchany G, Baruch M, Cornejo J, Hobert E, Dimise E, Ajo-Franklin CM, Clardy JeLifeAn elusive electron shuttle from a facultative anaerobe. Elife. 2019 06 24; 8.Elife2019-06-24T00:00:002019An elusive electron shuttle from a facultative anaerobe.GP84GlebPishchanyGleb Pishchany, Ph.D.110457Pishchany, GlebInstructor in Biological Chemistry and Molecular PharmacologyAuthorship 1175475931344052Paludo CR, Pishchany G, Andrade-Dominguez A, Silva-Junior EA, Menezes C, Nascimento FS, Currie CR, Kolter R, Clardy J, Pupo MTPloS oneMicrobial community modulates growth of symbiotic fungus required for stingless bee metamorphosis. PLoS One. 2019; 14(7):e0219696.PLoS One2019-07-25T00:00:002019Microbial community modulates growth of symbiotic fungus required for stingless bee metamorphosis.Authorship 1363175Authorship 1487447Authorship 1600212Authorship 1196600931600443Mevers E, Saurí J, Helfrich EJN, Henke M, Barns KJ, Bugni TS, Andes D, Currie CR, Clardy JJournal of the American Chemical SocietyPyonitrins A-D: Chimeric Natural Products Produced by Pseudomonas protegens. J Am Chem Soc. 2019 10 30; 141(43):17098-17101.J Am Chem Soc2019-10-16T00:00:002019Pyonitrins A-D: Chimeric Natural Products Produced by Pseudomonas protegens.true1Kurt J. Isselbacher Professor of Medicine in the Field of GastroenterologyKurt J. Isselbacher Professor of Medicine in the Field of Gastroenterologytrue1Professor of Microbiology and Immunobiology, EmeritusProfessor of Microbiology and Immunobiology, EmeritusAuthorship 1410054Authorship 1361144Authorship 1479662Authorship 12107774Authorship 1210423231839835Helfrich EJN, Lin GM, Voigt CA, Clardy JBeilstein journal of organic chemistryBacterial terpene biosynthesis: challenges and opportunities for pathway engineering. Beilstein J Org Chem. 2019; 15:2889-2906.Beilstein J Org Chem2019-11-29T00:00:002019Bacterial terpene biosynthesis: challenges and opportunities for pathway engineering.31831655Henke MT, Clardy JScience (New York, N.Y.)Molecular messages in human microbiota. Science. 2019 12 13; 366(6471):1309-1310.Science2019-12-13T00:00:002019Molecular messages in human microbiota.Authorship 1214664531896661Reisberg SH, Gao Y, Walker AS, Helfrich EJN, Clardy J, Baran PSScience (New York, N.Y.)Total synthesis reveals atypical atropisomerism in a small-molecule natural product, tryptorubin A. Science. 2020 01 24; 367(6476):458-463.Science2020-01-02T00:00:002020Total synthesis reveals atypical atropisomerism in a small-molecule natural product, tryptorubin A.Authorship 1211496Authorship 175785332315170Walker AS, Pishchany G, Clardy JBiochemistryParsing Molecules for Drug Discovery. Biochemistry. 2020 05 05; 59(17):1645-1646.Biochemistry2020-04-21T00:00:002020Parsing Molecules for Drug Discovery.Authorship 12415573Authorship 2010193Authorship 1742384Authorship 1351661Authorship 12506461532453775O'Connor RM, Nepveux V FJ, Abenoja J, Bowden G, Reis P, Beaushaw J, Bone Relat RM, Driskell I, Gimenez F, Riggs MW, Schaefer DA, Schmidt EW, Lin Z, Distel DL, Clardy J, Ramadhar TR, Allred DR, Fritz HM, Rathod P, Chery L, White JPLoS pathogensA symbiotic bacterium of shipworms produces a compound with broad spectrum anti-apicomplexan activity. PLoS Pathog. 2020 05; 16(5):e1008600.PLoS Pathog2020-05-26T00:00:002020A symbiotic bacterium of shipworms produces a compound with broad spectrum anti-apicomplexan activity.Authorship 1846595Authorship 1522523Authorship 1990767Authorship 1719466Authorship 12725591232738587Bowden GD, Reis PM, Rogers MB, Bone Relat RM, Brayton KA, Wilson SK, Di Genova BM, Knoll LJ, Nepveux V FJ, Tai AK, Ramadhar TR, Clardy J, O'Connor RMInternational journal for parasitology. Drugs and drug resistanceA conserved coccidian gene is involved in Toxoplasma sensitivity to the anti-apicomplexan compound, tartrolon E. Int J Parasitol Drugs Drug Resist. 2020 12; 14:1-7.Int J Parasitol Drugs Drug Resist2020-07-25T00:00:002020A conserved coccidian gene is involved in Toxoplasma sensitivity to the anti-apicomplexan compound, tartrolon E.true1Professor of Biological Chemistry and Molecular PharmacologyProfessor of Biological Chemistry and Molecular Pharmacologytrue1Lecturer on Biological Chemistry and Molecular PharmacologyLecturer on Biological Chemistry and Molecular Pharmacologytrue1Harold T. White Professor of Biological Chemistry and Molecular PharmacologyHarold T. White Professor of Biological Chemistry and Molecular PharmacologyBCMPAuthorship 1556116Authorship 1299446733101237Grubbs KJ, Surup F, Biedermann PHW, McDonald BR, Klassen JL, Carlson CM, Clardy J, Currie CRFrontiers in microbiologyCycloheximide-Producing Streptomyces Associated With Xyleborinus saxesenii and Xyleborus affinis Fungus-Farming Ambrosia Beetles. Front Microbiol. 2020; 11:562140.Front Microbiol2020-09-24T00:00:002020Cycloheximide-Producing Streptomyces Associated With Xyleborinus saxesenii and Xyleborus affinis Fungus-Farming Ambrosia Beetles.Authorship 235251233350306Jackson DR, Cassilly CD, Plichta DR, Vlamakis H, Liu H, Melville SB, Xavier RJ, Clardy JACS chemical biologyPlasmalogen Biosynthesis by Anaerobic Bacteria: Identification of a Two-Gene Operon Responsible for Plasmalogen Production in Clostridium perfringens. ACS Chem Biol. 2021 01 15; 16(1):6-13.ACS Chem Biol2020-12-22T00:00:002020Plasmalogen Biosynthesis by Anaerobic Bacteria: Identification of a Two-Gene Operon Responsible for Plasmalogen Production in Clostridium perfringens.Authorship 13129268Authorship 13141111433352109Ye L, Bae M, Cassilly CD, Jabba SV, Thorpe DW, Martin AM, Lu HY, Wang J, Thompson JD, Lickwar CR, Poss KD, Keating DJ, Jordt SE, Clardy J, Liddle RA, Rawls JFCell host & microbeEnteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways. Cell Host Microbe. 2021 02 10; 29(2):179-196.e9.Cell Host Microbe2020-12-21T00:00:002020Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways.Authorship 1463482Authorship 20859611Authorship 1330909933591189Bae M, Mevers E, Pishchany G, Whaley SG, Rock CO, Andes DR, Currie CR, Pupo MT, Clardy JOrganic lettersChemical Exchanges between Multilateral Symbionts. Org Lett. 2021 03 05; 23(5):1648-1652.Org Lett2021-02-16T00:00:002021Chemical Exchanges between Multilateral Symbionts.Authorship 1532415Authorship 13332237Authorship 1333554733613504Grubbs KJ, May DS, Sardina JA, Dermenjian RK, Wyche TP, Pinto-Tomás AA, Clardy J, Currie CRFrontiers in microbiologyPollen Streptomyces Produce Antibiotic That Inhibits the Honey Bee Pathogen Paenibacillus larvae. Front Microbiol. 2021; 12:632637.Front Microbiol2021-02-04T00:00:002021Pollen Streptomyces Produce Antibiotic That Inhibits the Honey Bee Pathogen Paenibacillus larvae.33620482Sittmann J, Bae M, Mevers E, Li M, Quinn A, Sriram G, Clardy J, Liu ZPlant physiologyBacterial diketopiperazines stimulate diatom growth and lipid accumulation. Plant Physiol. 2021 06 11; 186(2):1159-1170.Plant Physiol2021-06-11T00:00:002021Bacterial diketopiperazines stimulate diatom growth and lipid accumulation.Authorship 1336495933655067Fukuda TTH, Helfrich EJN, Mevers E, Melo WGP, Van Arnam EB, Andes DR, Currie CR, Pupo MT, Clardy JACS central scienceSpecialized Metabolites Reveal Evolutionary History and Geographic Dispersion of a Multilateral Symbiosis. ACS Cent Sci. 2021 Feb 24; 7(2):292-299.ACS Cent Sci2021-01-20T00:00:002021Specialized Metabolites Reveal Evolutionary History and Geographic Dispersion of a Multilateral Symbiosis.Authorship 15652512Authorship 1352722833962985Francoeur CB, May DS, Thairu MW, Hoang DQ, Panthofer O, Bugni TS, Pupo MT, Clardy J, Pinto-Tomás AA, Currie CRApplied and environmental microbiologyBurkholderia from Fungus Gardens of Fungus-Growing Ants Produces Antifungals That Inhibit the Specialized Parasite Escovopsis. Appl Environ Microbiol. 2021 06 25; 87(14):e0017821.Appl Environ Microbiol2021-06-25T00:00:002021Burkholderia from Fungus Gardens of Fungus-Growing Ants Produces Antifungals That Inhibit the Specialized Parasite Escovopsis.Authorship 1354755633972416Henke MT, Brown EM, Cassilly CD, Vlamakis H, Xavier RJ, Clardy JProceedings of the National Academy of Sciences of the United States of AmericaCapsular polysaccharide correlates with immune response to the human gut microbe Ruminococcus gnavus. Proc Natl Acad Sci U S A. 2021 05 18; 118(20).Proc Natl Acad Sci U S A2021-05-18T00:00:002021Capsular polysaccharide correlates with immune response to the human gut microbe Ruminococcus gnavus.Authorship 1359141234042443Walker AS, Clardy JJournal of chemical information and modelingA Machine Learning Bioinformatics Method to Predict Biological Activity from Biosynthetic Gene Clusters. J Chem Inf Model. 2021 06 28; 61(6):2560-2571.J Chem Inf Model2021-05-27T00:00:002021A Machine Learning Bioinformatics Method to Predict Biological Activity from Biosynthetic Gene Clusters.true1Instructor in Biological Chemistry and Molecular PharmacologyInstructor in Biological Chemistry and Molecular PharmacologyAuthorship 1854885Authorship 1888564Authorship 1385912934417172Wasson JA, Harris G, Keppler-Ross S, Brock TJ, Dar AR, Butcher RA, Fischer SEJ, Kagias K, Clardy J, Zhang Y, Mango SEScience advancesNeuronal control of maternal provisioning in response to social cues. Sci Adv. 2021 Aug; 7(34).Sci Adv2021-08-20T00:00:002021Neuronal control of maternal provisioning in response to social cues.Authorship 175303Authorship 1855834Authorship 1413381334734219Cech NB, Medema MH, Clardy JNatural product reportsBenefiting from big data in natural products: importance of preserving foundational skills and prioritizing data quality. Nat Prod Rep. 2021 11 17; 38(11):1947-1953.Nat Prod Rep2021-11-17T00:00:002021Benefiting from big data in natural products: importance of preserving foundational skills and prioritizing data quality.35049898Yan JX, Wu Q, Helfrich EJN, Chevrette MG, Braun DR, Heyman H, Ananiev GE, Rajski SR, Currie CR, Clardy J, Bugni TSMarine drugsBacillimidazoles A-F, Imidazolium-Containing Compounds Isolated from a Marine Bacillus. Mar Drugs. 2022 Jan 01; 20(1).Mar Drugs2022-01-01T00:00:002022Bacillimidazoles A-F, Imidazolium-Containing Compounds Isolated from a Marine Bacillus.Authorship 142720110Authorship 1432163935129341Szamosvári D, Bae M, Bang S, Tusi BK, Cassilly CD, Park SM, Graham DB, Xavier RJ, Clardy JJournal of the American Chemical SocietyLyme Disease, Borrelia burgdorferi, and Lipid Immunogens. J Am Chem Soc. 2022 02 16; 144(6):2474-2478.J Am Chem Soc2022-02-07T00:00:002022Lyme Disease, Borrelia burgdorferi, and Lipid Immunogens.Authorship 2562574Authorship 2862204Authorship 2902224Authorship 3312814Authorship 3601555Authorship 3690517Authorship 14626001535896748Bae M, Cassilly CD, Liu X, Park SM, Tusi BK, Chen X, Kwon J, Filipcík P, Bolze AS, Liu Z, Vlamakis H, Graham DB, Buhrlage SJ, Xavier RJ, Clardy JNatureAkkermansia muciniphila phospholipid induces homeostatic immune responses. Nature. 2022 08; 608(7921):168-173.Nature2022-07-27T00:00:002022Akkermansia muciniphila phospholipid induces homeostatic immune responses.Authorship 4016503true1Director, HMS Bio-NMR CoreDirector, HMS Bio-NMR CoreAuthorship 4147212Authorship 4377484Authorship 1507524536452178Murugkar P, Dimise E, Stewart E, Viala SN, Clardy J, Dewhirst FE, Lewis KJournal of oral microbiologyIdentification of a growth factor required for culturing specific fastidious oral bacteria. J Oral Microbiol. 2023; 15(1):2143651.J Oral Microbiol2022-11-25T00:00:002022Identification of a growth factor required for culturing specific fastidious oral bacteria.Authorship 2294562Authorship 1525915236758518Brown EM, Clardy J, Xavier RJCell host & microbeGut microbiome lipid metabolism and its impact on host physiology. Cell Host Microbe. 2023 02 08; 31(2):173-186.Cell Host Microbe2023-02-08T00:00:002023Gut microbiome lipid metabolism and its impact on host physiology.Authorship 1533345836952265Kwon J, Bae M, Szamosvári D, Cassilly CD, Bolze AS, Jackson DR, Xavier RJ, Clardy JJournal of the American Chemical SocietyCollinsella aerofaciens Produces a pH-Responsive Lipid Immunogen. J Am Chem Soc. 2023 04 05; 145(13):7071-7074.J Am Chem Soc2023-03-23T00:00:002023Collinsella aerofaciens Produces a pH-Responsive Lipid Immunogen.true1Hamilton Kuhn Professor of Biological Chemistry and Molecular PharmacologyHamilton Kuhn Professor of Biological Chemistry and Molecular PharmacologyAuthorship 1568162237163788Seyedsayamdost MR, Clardy JCurrent opinion in chemical biologyDiscovering functional small molecules in the gut microbiome. Curr Opin Chem Biol. 2023 08; 75:102309.Curr Opin Chem Biol2023-05-08T00:00:002023Discovering functional small molecules in the gut microbiome.true1Christopher T. Walsh, PhD Professor of Biological Chemistry and Molecular PharmacologyChristopher T. Walsh, PhD Professor of Biological Chemistry and Molecular PharmacologyAuthorship 3342494Authorship 3428608Authorship 1589593837738205Shin YH, Bang S, Park SM, Ma X, Cassilly C, Graham D, Xavier R, Clardy JJournal of the American Chemical SocietyRevisiting Coley's Toxins: Immunogenic Cardiolipins from Streptococcus pyogenes. J Am Chem Soc. 2023 10 04; 145(39):21183-21188.J Am Chem Soc2023-09-22T00:00:002023Revisiting Coley's Toxins: Immunogenic Cardiolipins from Streptococcus pyogenes.Authorship 1601960737871232Bang S, Shin YH, Ma X, Park SM, Graham DB, Xavier RJ, Clardy JJournal of the American Chemical SocietyA Cardiolipin from Muribaculum intestinale Induces Antigen-Specific Cytokine Responses. J Am Chem Soc. 2023 11 01; 145(43):23422-23426.J Am Chem Soc2023-10-23T00:00:002023A Cardiolipin from Muribaculum intestinale Induces Antigen-Specific Cytokine Responses.Authorship 460553Authorship 1607470537973865King AM, Zhang Z, Glassey E, Siuti P, Clardy J, Voigt CANature microbiologySystematic mining of the human microbiome identifies antimicrobial peptides with diverse activity spectra. Nat Microbiol. 2023 Dec; 8(12):2420-2434.Nat Microbiol2023-11-16T00:00:002023Systematic mining of the human microbiome identifies antimicrobial peptides with diverse activity spectra.Authorship 5180348Authorship 5619604Authorship 5252871true1Richard Pearson Strong Professor of Infectious DiseasesRichard Pearson Strong Professor of Infectious Diseasestrue1Visiting Professor of Systems Biology in the Wyss InstituteVisiting Professor of Systems Biology in the Wyss Institutetrue1Assistant Professor of RadiologyAssistant Professor of Radiologytrue1Visiting ScientistVisiting ScientistAuthorship 5600673Authorship 1623537Authorship 2847693Authorship 3077574Authorship 3322937Authorship 3567326Authorship 4707065Authorship 2502534Authorship 3325874Authorship 493157Authorship 6480692Authorship 6551915Authorship 668278523874157Wieland Brown LC, Penaranda C, Kashyap PC, Williams BB, Clardy J, Kronenberg M, Sonnenburg JL, Comstock LE, Bluestone JA, Fischbach MAPLoS biologyProduction of a-galactosylceramide by a prominent member of the human gut microbiota. PLoS Biol. 2013 Jul; 11(7):e1001610.PLoS Biol2013-07-16T00:00:002013Production of a-galactosylceramide by a prominent member of the human gut microbiota.23815260Kim KH, Choi SU, Son MW, Choi SZ, Clardy J, Lee KRJournal of natural productsPharbinilic acid, an allogibberic acid from morning glory (Pharbitis nil). J Nat Prod. 2013 Jul 26; 76(7):1376-9.J Nat Prod2013-07-01T00:00:002013Pharbinilic acid, an allogibberic acid from morning glory (Pharbitis nil).23853715Derbyshire ER, Clardy JeLifeClosing in on a new treatment for sleeping sickness. Elife. 2013 Jul 09; 2:e01042.Elife2013-07-09T00:00:002013Closing in on a new treatment for sleeping sickness.Authorship 559135Authorship 2198989Authorship 677097723898207Stallforth P, Brock DA, Cantley AM, Tian X, Queller DC, Strassmann JE, Clardy JProceedings of the National Academy of Sciences of the United States of AmericaA bacterial symbiont is converted from an inedible producer of beneficial molecules into food by a single mutation in the gacA gene. Proc Natl Acad Sci U S A. 2013 Sep 03; 110(36):14528-33.Proc Natl Acad Sci U S A2013-07-29T00:00:002013A bacterial symbiont is converted from an inedible producer of beneficial molecules into food by a single mutation in the gacA gene.Authorship 2046504Authorship 2686204Authorship 6882966Authorship 689766523861933Sakai N, Iwata R, Yokoi S, Butcher RA, Clardy J, Tomioka M, Iino YPloS oneA sexually conditioned switch of chemosensory behavior in C. elegans. PLoS One. 2013; 8(7):e68676.PLoS One2013-07-04T00:00:002013A sexually conditioned switch of chemosensory behavior in C. elegans.23593306Cheng B, Cao S, Vasquez V, Annamalai T, Tamayo-Castillo G, Clardy J, Tse-Dinh YCPloS oneIdentification of anziaic acid, a lichen depside from Hypotrachyna sp., as a new topoisomerase poison inhibitor. PLoS One. 2013; 8(4):e60770.PLoS One2013-04-08T00:00:002013Identification of anziaic acid, a lichen depside from Hypotrachyna sp., as a new topoisomerase poison inhibitor.Authorship 3371194Authorship 3755907Authorship 3854466Authorship 1978824Authorship 2042673Authorship 2433996Authorship 246744Authorship 2774974Authorship 1725202Authorship 2647318Authorship 2960135Authorship 7084Authorship 2091299Authorship 304493423921819Ramadhar TR, Beemelmanns C, Currie CR, Clardy JThe Journal of antibioticsBacterial symbionts in agricultural systems provide a strategic source for antibiotic discovery. J Antibiot (Tokyo). 2014 Jan; 67(1):53-8.J Antibiot (Tokyo)2013-08-07T00:00:002013Bacterial symbionts in agricultural systems provide a strategic source for antibiotic discovery.Authorship 70756710Authorship 7075865Authorship 7076387Authorship 7096467Authorship 7143382Authorship 7251448Authorship 7157354Authorship 72354722351617Shin-ya K, Imai S, Furihata K, Hayakawa Y, Kato Y, Vanduyne GD, Clardy J, Seto HThe Journal of antibioticsIsolation and structural elucidation of an antioxidative agent, naphterpin. J Antibiot (Tokyo). 1990 Apr; 43(4):444-7.J Antibiot (Tokyo)1990-04-01T00:00:001990Isolation and structural elucidation of an antioxidative agent, naphterpin.6725143Flegel TW, Meevootisom V, Thebtaranonth Y, Qi-Tai Z, Clardy JThe Journal of antibioticsA new naphthaquinone antibiotic from a new species of yeast. J Antibiot (Tokyo). 1984 Apr; 37(4):325-9.J Antibiot (Tokyo)1984-04-01T00:00:001984A new naphthaquinone antibiotic from a new species of yeast.3755428Smitka TA, Bunge RH, Wilton JH, Hokanson GC, French JC, He CH, Clardy JThe Journal of antibioticsPD 116,152, a new phenazine antitumor antibiotic. Structure and antitumor activity. J Antibiot (Tokyo). 1986 Jun; 39(6):800-3.J Antibiot (Tokyo)1986-06-01T00:00:001986PD 116,152, a new phenazine antitumor antibiotic. Structure and antitumor activity.2793600Konishi M, Ohkuma H, Matsumoto K, Tsuno T, Kamei H, Miyaki T, Oki T, Kawaguchi H, VanDuyne GD, Clardy JThe Journal of antibioticsDynemicin A, a novel antibiotic with the anthraquinone and 1,5-diyn-3-ene subunit. J Antibiot (Tokyo). 1989 Sep; 42(9):1449-52.J Antibiot (Tokyo)1989-09-01T00:00:001989Dynemicin A, a novel antibiotic with the anthraquinone and 1,5-diyn-3-ene subunit.24366746Derbyshire ER, Min J, Guiguemde WA, Clark JA, Connelly MC, Magalhães AD, Guy RK, Clardy JAntimicrobial agents and chemotherapyDihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites. Antimicrob Agents Chemother. 2014; 58(3):1516-22.Antimicrob Agents Chemother2013-12-23T00:00:002013Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites.24554079Stallforth P, Clardy JProceedings of the National Academy of Sciences of the United States of AmericaAtlas for drug discovery. Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10):3655-6.Proc Natl Acad Sci U S A2014-02-19T00:00:002014Atlas for drug discovery.24615751Böttcher T, Clardy JAngewandte Chemie (International ed. in English)A chimeric siderophore halts swarming Vibrio. Angew Chem Int Ed Engl. 2014 Mar 24; 53(13):3510-3.Angew Chem Int Ed Engl2014-02-24T00:00:002014A chimeric siderophore halts swarming Vibrio.Authorship 2090128Authorship 481516Authorship 858046Authorship 7285931624684906Gavrish E, Sit CS, Cao S, Kandror O, Spoering A, Peoples A, Ling L, Fetterman A, Hughes D, Bissell A, Torrey H, Akopian T, Mueller A, Epstein S, Goldberg A, Clardy J, Lewis KChemistry & biologyLassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2. Chem Biol. 2014 Apr 24; 21(4):509-518.Chem Biol2014-03-27T00:00:002014Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2.Authorship 2191914Authorship 3380755Authorship 1787817Authorship 3479038Authorship 4233134Authorship 3285578Authorship 2931045Authorship 3444386Authorship 32614511Authorship 3735523Authorship 4755033Authorship 74794513Authorship 74868510Authorship 7496196Authorship 5000941224983513Beemelmanns C, Woznica A, Alegado RA, Cantley AM, King N, Clardy JJournal of the American Chemical SocietySynthesis of the rosette-inducing factor RIF-1 and analogs. J Am Chem Soc. 2014 Jul 23; 136(29):10210-3.J Am Chem Soc2014-07-10T00:00:002014Synthesis of the rosette-inducing factor RIF-1 and analogs.25111632Derbyshire ER, Zuzarte-Luís V, Magalhães AD, Kato N, Sanschagrin PC, Wang J, Zhou W, Miduturu CV, Mazitschek R, Sliz P, Mota MM, Gray NS, Clardy JChembiochem : a European journal of chemical biologyChemical interrogation of the malaria kinome. Chembiochem. 2014 Sep 05; 15(13):1920-30.Chembiochem2014-08-08T00:00:002014Chemical interrogation of the malaria kinome.25036635Cimermancic P, Medema MH, Claesen J, Kurita K, Wieland Brown LC, Mavrommatis K, Pati A, Godfrey PA, Koehrsen M, Clardy J, Birren BW, Takano E, Sali A, Linington RG, Fischbach MACellInsights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. Cell. 2014 Jul 17; 158(2):412-421.Cell2014-07-17T00:00:002014Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters.Authorship 3469257Authorship 3523542Authorship 756588725086086Raveh A, Schultz PJ, Aschermann L, Carpenter C, Tamayo-Castillo G, Cao S, Clardy J, Neubig RR, Sherman DH, Sjögren BMolecular pharmacologyIdentification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts. Mol Pharmacol. 2014 Oct; 86(4):406-16.Mol Pharmacol2014-08-01T00:00:002014Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts.Authorship 5540432Authorship 758519725215495Donia MS, Cimermancic P, Schulze CJ, Wieland Brown LC, Martin J, Mitreva M, Clardy J, Linington RG, Fischbach MACellA systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics. Cell. 2014 Sep 11; 158(6):1402-1414.Cell2014-09-11T00:00:002014A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics.Authorship 761380824837391Book AJ, Lewin GR, McDonald BR, Takasuka TE, Doering DT, Adams AS, Blodgett JA, Clardy J, Raffa KF, Fox BG, Currie CRApplied and environmental microbiologyCellulolytic Streptomyces strains associated with herbivorous insects share a phylogenetically linked capacity to degrade lignocellulose. Appl Environ Microbiol. 2014 Aug; 80(15):4692-701.Appl Environ Microbiol2014-08-01T00:00:002014Cellulolytic Streptomyces strains associated with herbivorous insects share a phylogenetically linked capacity to degrade lignocellulose.Authorship 3768812Authorship 4189295Authorship 763602224742095Seyedsayamdost MR, Clardy JACS synthetic biologyNatural products and synthetic biology. ACS Synth Biol. 2014 Oct 17; 3(10):745-7.ACS Synth Biol2014-01-07T00:00:002014Natural products and synthetic biology.Authorship 4424094Authorship 765537425295497Seyedsayamdost MR, Wang R, Kolter R, Clardy JJournal of the American Chemical SocietyHybrid biosynthesis of roseobacticides from algal and bacterial precursor molecules. J Am Chem Soc. 2014 Oct 29; 136(43):15150-3.J Am Chem Soc2014-10-21T00:00:002014Hybrid biosynthesis of roseobacticides from algal and bacterial precursor molecules.Authorship 885893Authorship 4719352Authorship 4250433Authorship 238541425386334Kim KH, Ramadhar TR, Beemelmanns C, Cao S, Poulsen M, Currie CR, Clardy JChemical scienceNatalamycin A, an Ansamycin from a Termite-Associated Streptomyces sp. Chem Sci. 2014 Nov 01; 5(11):4333-4338.Chem Sci2014-11-01T00:00:002014Natalamycin A, an Ansamycin from a Termite-Associated Streptomyces sp.Authorship 4465012Authorship 4473905Authorship 778356425537388Ramadhar TR, Zheng SL, Chen YS, Clardy JActa crystallographica. Section A, Foundations and advancesAnalysis of rapidly synthesized guest-filled porous complexes with synchrotron radiation: practical guidelines for the crystalline sponge method. Acta Crystallogr A Found Adv. 2015 Jan; 71(Pt 1):46-58.Acta Crystallogr A Found Adv2015-01-01T00:00:002015Analysis of rapidly synthesized guest-filled porous complexes with synchrotron radiation: practical guidelines for the crystalline sponge method.Authorship 3171062Authorship 3205804Authorship 406623Authorship 5407936Authorship 5443193Authorship 5674358Authorship 5731863Authorship 724431Authorship 881484Authorship 686895Authorship 782213Authorship 83603Authorship 4037353Authorship 4157414Authorship 4235608Authorship 3296402Authorship 2275683Authorship 5048607Authorship 4942942Authorship 5720685Authorship 5653557Authorship 5077952Authorship 41310210Authorship 1727346Authorship 2356278Authorship 2925588Authorship 5479813Authorship 5104045Authorship 5162195Authorship 579082Authorship 2245977Authorship 1036434Authorship 3433017Authorship 2676375Authorship 2856003Authorship 2788418Authorship 307155Authorship 316577Authorship 3182924Authorship 3628689Authorship 3994333Authorship 44537611Authorship 4742337Authorship 51059712Authorship 2304523Authorship 5692117Authorship 5718582Authorship 3637786Authorship 3660807Authorship 4129542Authorship 2391067Authorship 3547774Authorship 218505Authorship 2536715Authorship 3100054Authorship 3151966Authorship 377524Authorship 4192743Authorship 4425435Authorship 4533764Authorship 4683638Authorship 5144882Authorship 544312Authorship 3891135Authorship 406704Authorship 4253253Authorship 4318991Authorship 4881614Authorship 7904235Authorship 7982623Authorship 7957151825995223Herman JD, Pepper LR, Cortese JF, Estiu G, Galinsky K, Zuzarte-Luis V, Derbyshire ER, Ribacke U, Lukens AK, Santos SA, Patel V, Clish CB, Sullivan WJ, Zhou H, Bopp SE, Schimmel P, Lindquist S, Clardy J, Mota MM, Keller TL, Whitman M, Wiest O, Wirth DF, Mazitschek RScience translational medicineThe cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med. 2015 May 20; 7(288):288ra77.Sci Transl Med2015-05-20T00:00:002015The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.25611215Kim KH, Park YJ, Chung KH, Yip ML, Clardy J, Senger D, Cao SJournal of natural productsIridoid glycosides from Barleria lupulina. J Nat Prod. 2015 Feb 27; 78(2):320-4.J Nat Prod2015-01-22T00:00:002015Iridoid glycosides from Barleria lupulina.25981688Kim KH, Beemelmanns C, Clardy J, Cao SBioorganic & medicinal chemistry lettersA new antibacterial octaketide and cytotoxic phenylethanoid glycosides from Pogostemon cablin (Blanco) Benth. Bioorg Med Chem Lett. 2015 Jul 15; 25(14):2834-6.Bioorg Med Chem Lett2015-05-06T00:00:002015A new antibacterial octaketide and cytotoxic phenylethanoid glycosides from Pogostemon cablin (Blanco) Benth.Authorship 259323Authorship 2837433Authorship 2994544Authorship 3210165Authorship 2570363Authorship 3773307Authorship 43707419Authorship 4915481Authorship 3887887Authorship 40272314Authorship 405895Authorship 4325032Authorship 4631045Authorship 5121955Authorship 5366513Authorship 580932Authorship 1791325Authorship 4645891Authorship 8080184Authorship 812747226081991Ramadhar TR, Zheng SL, Chen YS, Clardy JChemical communications (Cambridge, England)The crystalline sponge method: MOF terminal ligand effects. Chem Commun (Camb). 2015 Jun 30; 51(56):11252-5.Chem Commun (Camb)2015-06-30T00:00:002015The crystalline sponge method: MOF terminal ligand effects.25656944Cantley AM, Clardy JNatural product reportsAnimals in a bacterial world: opportunities for chemical ecology. Nat Prod Rep. 2015 Jul; 32(7):888-92.Nat Prod Rep2015-07-01T00:00:002015Animals in a bacterial world: opportunities for chemical ecology.Authorship 3025295Authorship 3095395Authorship 3524414Authorship 385945726242912Byun S, Lim S, Mun JY, Kim KH, Ramadhar TR, Farrand L, Shin SH, Thimmegowda NR, Lee HJ, Frank DA, Clardy J, Lee SW, Lee KWThe Journal of biological chemistryIdentification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways. J Biol Chem. 2015 Sep 25; 290(39):23553-62.J Biol Chem2015-08-04T00:00:002015Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways.Authorship 4227925Authorship 4372389Authorship 8256716626284661Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FONature chemical biologyMinimum Information about a Biosynthetic Gene cluster. Nat Chem Biol. 2015 Sep; 11(9):625-31.Nat Chem Biol2015-09-01T00:00:002015Minimum Information about a Biosynthetic Gene cluster.Authorship 5127977Authorship 5496834Authorship 5631555Authorship 5672807Authorship 8333401626320861Hiraki M, Hwang SY, Cao S, Ramadhar TR, Byun S, Yoon KW, Lee JH, Chu K, Gurkar AU, Kolev V, Zhang J, Namba T, Murphy ME, Newman DJ, Mandinova A, Clardy J, Lee SWChemistry & biologySmall-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis. Chem Biol. 2015 Sep 17; 22(9):1206-16.Chem Biol2015-08-27T00:00:002015Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis.Authorship 8378111126438860Sit CS, Ruzzini AC, Van Arnam EB, Ramadhar TR, Currie CR, Clardy JProceedings of the National Academy of Sciences of the United States of AmericaVariable genetic architectures produce virtually identical molecules in bacterial symbionts of fungus-growing ants. Proc Natl Acad Sci U S A. 2015 Oct 27; 112(43):13150-4.Proc Natl Acad Sci U S A2015-10-05T00:00:002015Variable genetic architectures produce virtually identical molecules in bacterial symbionts of fungus-growing ants.Authorship 4313815Authorship 433587Authorship 84236515Authorship 843180626465675Cheng KC, Cao S, Raveh A, MacArthur R, Dranchak P, Chlipala G, Okoneski MT, Guha R, Eastman RT, Yuan J, Schultz PJ, Su XZ, Tamayo-Castillo G, Matainaho T, Clardy J, Sherman DH, Inglese JJournal of natural productsActinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts. J Nat Prod. 2015 Oct 23; 78(10):2411-22.J Nat Prod2015-10-14T00:00:002015Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts.Authorship 4651256Authorship 848541526535611Van Arnam EB, Ruzzini AC, Sit CS, Currie CR, Clardy JJournal of the American Chemical SocietyA Rebeccamycin Analog Provides Plasmid-Encoded Niche Defense. J Am Chem Soc. 2015 Nov 18; 137(45):14272-4.J Am Chem Soc2015-11-10T00:00:002015A Rebeccamycin Analog Provides Plasmid-Encoded Niche Defense.Authorship 8527126Authorship 853275626659670Klassen JL, Rischer M, Wolf T, Guo H, Shelest E, Clardy J, Beemelmanns CGenome announcementsGenome Sequences of Three Pseudoalteromonas Strains (P1-8, P1-11, and P1-30), Isolated from the Marine Hydroid Hydractinia echinata. Genome Announc. 2015 Dec 10; 3(6).Genome Announc2015-12-10T00:00:002015Genome Sequences of Three Pseudoalteromonas Strains (P1-8, P1-11, and P1-30), Isolated from the Marine Hydroid Hydractinia echinata.26679587Klassen JL, Wolf T, Rischer M, Guo H, Shelest E, Clardy J, Beemelmanns CGenome announcementsDraft Genome Sequences of Six Pseudoalteromonas Strains, P1-7a, P1-9, P1-13-1a, P1-16-1b, P1-25, and P1-26, Which Induce Larval Settlement and Metamorphosis in Hydractinia echinata. Genome Announc. 2015 Dec 17; 3(6).Genome Announc2015-12-17T00:00:002015Draft Genome Sequences of Six Pseudoalteromonas Strains, P1-7a, P1-9, P1-13-1a, P1-16-1b, P1-25, and P1-26, Which Induce Larval Settlement and Metamorphosis in Hydractinia echinata.Authorship 5340229Authorship 566602726910435Böttcher T, Elliott HL, Clardy JBiophysical journalDynamics of Snake-like Swarming Behavior of Vibrio alginolyticus. Biophys J. 2016 Feb 23; 110(4):981-92.Biophys J2016-02-23T00:00:002016Dynamics of Snake-like Swarming Behavior of Vibrio alginolyticus.Authorship 8632564Authorship 8664326Authorship 869937326893410Rischer M, Klassen JL, Wolf T, Guo H, Shelest E, Clardy J, Beemelmanns CGenome announcementsDraft Genome Sequence of Shewanella sp. Strain P1-14-1, a Bacterial Inducer of Settlement and Morphogenesis in Larvae of the Marine Hydroid Hydractinia echinata. Genome Announc. 2016 Feb 18; 4(1).Genome Announc2016-02-18T00:00:002016Draft Genome Sequence of Shewanella sp. Strain P1-14-1, a Bacterial Inducer of Settlement and Morphogenesis in Larvae of the Marine Hydroid Hydractinia echinata.26666931Raphemot R, Lafuente-Monasterio MJ, Gamo-Benito FJ, Clardy J, Derbyshire ERAntimicrobial agents and chemotherapyDiscovery of Dual-Stage Malaria Inhibitors with New Targets. Antimicrob Agents Chemother. 2015 Dec 14; 60(3):1430-7.Antimicrob Agents Chemother2015-12-14T00:00:002015Discovery of Dual-Stage Malaria Inhibitors with New Targets.Authorship 3270414Authorship 873239827013050Paludo CR, Ruzzini AC, Silva-Junior EA, Pishchany G, Currie CR, Nascimento FS, Kolter RG, Clardy J, Pupo MTGenome announcementsWhole-Genome Sequence of Bacillus sp. SDLI1, Isolated from the Social Bee Scaptotrigona depilis. Genome Announc. 2016 Mar 24; 4(2).Genome Announc2016-03-24T00:00:002016Whole-Genome Sequence of Bacillus sp. SDLI1, Isolated from the Social Bee Scaptotrigona depilis.Authorship 873963526998963Cantley AM, Woznica A, Beemelmanns C, King N, Clardy JJournal of the American Chemical SocietyIsolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates. J Am Chem Soc. 2016 Apr 06; 138(13):4326-9.J Am Chem Soc2016-03-24T00:00:002016Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates.Authorship 4090075Authorship 4364314Authorship 4757557Authorship 882408527101411Lear S, Munshi T, Hudson AS, Hatton C, Clardy J, Mosely JA, Bull TJ, Sit CS, Cobb SLOrganic & biomolecular chemistryTotal chemical synthesis of lassomycin and lassomycin-amide. Org Biomol Chem. 2016 May 11; 14(19):4534-41.Org Biomol Chem2016-05-11T00:00:002016Total chemical synthesis of lassomycin and lassomycin-amide.Authorship 5273214Authorship 887217427080179Lee S, Tamayo-Castillo G, Pang C, Clardy J, Cao S, Kim KHBioorganic & medicinal chemistry lettersDiketopiperazines from Costa Rican endolichenic fungus Colpoma sp. CR1465A. Bioorg Med Chem Lett. 2016 05 15; 26(10):2438-2441.Bioorg Med Chem Lett2016-04-02T00:00:002016Diketopiperazines from Costa Rican endolichenic fungus Colpoma sp. CR1465A.Authorship 662613Authorship 687962Authorship 958042Authorship 55412542Assistant Professor0Full Professor4Instructor3Lecturer5Other FacultyAuthorship 767524Authorship 5569744Authorship 8918034Authorship 8919775Authorship 8916931327354530Woznica A, Cantley AM, Beemelmanns C, Freinkman E, Clardy J, King NProceedings of the National Academy of Sciences of the United States of AmericaBacterial lipids activate, synergize, and inhibit a developmental switch in choanoflagellates. Proc Natl Acad Sci U S A. 2016 07 12; 113(28):7894-9.Proc Natl Acad Sci U S A2016-06-27T00:00:002016Bacterial lipids activate, synergize, and inhibit a developmental switch in choanoflagellates.27396193Lee SR, Beemelmanns C, Tsuma LM, Clardy J, Cao S, Kim KHNatural product communicationsA New Diketopiperazine, Cyclo(D-trans-Hyp-L-Leu) from a Kenyan Bacterium Bacillus licheniformis LB 8CT. Nat Prod Commun. 2016 Apr; 11(4):461-3.Nat Prod Commun2016-04-01T00:00:002016A New Diketopiperazine, Cyclo(D-trans-Hyp-L-Leu) from a Kenyan Bacterium Bacillus licheniformis LB 8CT.27368101Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, Kaelin WGCellParacrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine. Cell. 2016 Jun 30; 166(1):126-39.Cell2016-06-30T00:00:002016Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine.Authorship 893889827445382Chagas FO, Ruzzini AC, Bacha LV, Samborskyy M, Conti R, Pessotti RC, de Oliveira LG, Clardy J, Pupo MTGenome announcementsGenome Sequence of Streptomyces sp. Strain RTd22, an Endophyte of the Mexican Sunflower. Genome Announc. 2016 Jul 21; 4(4).Genome Announc2016-07-21T00:00:002016Genome Sequence of Streptomyces sp. Strain RTd22, an Endophyte of the Mexican Sunflower.Authorship 6673Authorship 671062Authorship 5725887Authorship 5603387Authorship 5618614Authorship 56875242015-02-28KASPER, DENNIS L.2003-09-04New England Regional Center of Excellence in Biodefense and Emerging Infectious DU54AI0571591988-04-30CLARDY, JON1987-05-01BIOMEDICAL HIGH PERFORMANCE MASS SPECTROMETERS10RR0035201995-06-30CLARDY, JON1989-09-01NEW ANTICANCER DRUGS FROM CULTURED AND COLLECTED MARINEU01CA0507502006-08-31CLARDY, JON2004-09-30High-throughput Screens for P. falciparum Malaria (RMI)R03NS0507672011-07-31D'ANDREA, ALAN D.2005-08-31Centers for Medical Countermeasures Against RadiationU19AI0677512012-04-30IRELAND, CHRIS M.1995-09-08ANTICANCER AGENTS FROM UNIQUE NATURAL PRODUCTS SOURCESU19CA0677862013-03-31EALICK, STEVEN E2001-06-15An Undulator Resource for Structural BiologyP41RR0153012019-03-31ANDES, DAVID R2014-04-10Antimicrobial Drug Discovery from Coevolved Symbiotic CommunitiesU19AI1096732013-06-30CERIONE, RICHARD A.1983-09-01Macromolecular Diffraction Resource: MacCHESSP41RR0016462007-08-31CLARDY, JON2005-09-30Phenotypic-based high throughput screens-Plasmodium(RMI)R21NS0536602021-07-31CLARDY, JON2014-08-01Novel therapeutic agents from the bacterial symbionts of Brazilian invertebratesU19TW0098722001-11-30COLEMAN, THOMAS F1992-04-15PARALLEL PROCESSING RESOURCE FOR BIOMEDICAL SCIENTISTSP41RR0042932016-05-31SHERMAN, DAVID H2005-09-29Discovery of Natural Product based Drugs and Bioenergetic Materials from CRU01TW0074042009-01-31CLARDY, JON1992-07-10Structural and Functional Studies on ProteinsR01CA0590212011-07-31EISENBERG, DAVID M2006-09-22International Center for the Evaluation of East Asian Botanicals for CancerU19CA1285341989-01-10CLARDY, JON1988-01-11X-RAY DIFFRACTION INSTRUMENTATIONS10RR0041502011-08-31CLARDY, JON2007-09-30Target-Based High-Throughput Screens for Plasmodium falciparum MalariaR21NS0594042006-04-30CLARDY, JON2003-09-30Potential Drugs from Poorly Understood Costa Rican BiotaR21TW0066352002-09-14MOFFAT, JOHN KEITH1992-09-15BIOCARS A SYNCHROTRON STRUCTURAL BIOLOGY RESOURCEU41RR0077072011-08-31CLARDY, JON1979-02-01Applications of Natural Products to Chemical BiologyR01CA0244872017-02-28CLARDY, JON2008-09-09Chemical biology of bacterial symbiontsR01GM0862581998-06-15CLARDY, JON1997-06-16AUTOMATED IMAGE PLATE DATA COLLECTION EQUIPMENTS10RR011935Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorCo-Principal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorAuthorship 818765Authorship 915242927622560Vafai SB, Mevers E, Higgins KW, Fomina Y, Zhang J, Mandinova A, Newman D, Shaw SY, Clardy J, Mootha VKPloS oneNatural Product Screening Reveals Naphthoquinone Complex I Bypass Factors. PLoS One. 2016; 11(9):e0162686.PLoS One2016-09-13T00:00:002016Natural Product Screening Reveals Naphthoquinone Complex I Bypass Factors.Authorship 9181869Authorship 918173227608853Mevers E, Saurí J, Liu Y, Moser A, Ramadhar TR, Varlan M, Williamson RT, Martin GE, Clardy JJournal of the American Chemical SocietyHomodimericin A: A Complex Hexacyclic Fungal Metabolite. J Am Chem Soc. 2016 09 28; 138(38):12324-7.J Am Chem Soc2016-09-16T00:00:002016Homodimericin A: A Complex Hexacyclic Fungal Metabolite.27676308Ruzzini AC, Clardy JCurrent biology : CBGene Flow and Molecular Innovation in Bacteria. Curr Biol. 2016 09 26; 26(18):R859-R864.Curr Biol2016-09-26T00:00:002016Gene Flow and Molecular Innovation in Bacteria.Authorship 763665Authorship 840999Authorship 343423Authorship 344278Authorship 3470035Authorship 9201965Authorship 9197082Authorship 9266925Authorship 92488237Authorship 924485721643520Cao S, Clardy JTetrahedron lettersNew naphthoquinones and a new d-lactone produced by endophytic fungi from Costa Rica. Tetrahedron Lett. 2011 Apr 27; 52(17):2206-2208.Tetrahedron Lett2011-04-27T00:00:002011New naphthoquinones and a new d-lactone produced by endophytic fungi from Costa Rica.20160864Freinkman E, Oh DC, Scott JJ, Currie CR, Clardy JTetrahedron lettersBionectriol A, a polyketide glycoside from the fungus Bionectria sp. associated with the fungus-growing ant, Apterostigma dentigerum. Tetrahedron Lett. 2009 Dec 01; 50(49):6834-6837.Tetrahedron Lett2009-12-01T00:00:002009Bionectriol A, a polyketide glycoside from the fungus Bionectria sp. associated with the fungus-growing ant, Apterostigma dentigerum.27602946Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan GL, Duffy S, Eckley S, Itoe MA, Koolen KM, Lewis TA, Lui PS, Lukens AK, Lund E, March S, Meibalan E, Meier BC, McPhail JA, Mitasev B, Moss EL, Sayes M, Van Gessel Y, Wawer MJ, Yoshinaga T, Zeeman AM, Avery VM, Bhatia SN, Burke JE, Catteruccia F, Clardy JC, Clemons PA, Dechering KJ, Duvall JR, Foley MA, Gusovsky F, Kocken CH, Marti M, Morningstar ML, Munoz B, Neafsey DE, Sharma A, Winzeler EA, Wirth DF, Scherer CA, Schreiber SLNatureDiversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. 2016 Oct 20; 538(7625):344-349.Nature2016-09-07T00:00:002016Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.27642863Stone LK, Baym M, Lieberman TD, Chait R, Clardy J, Kishony RNature chemical biologyCompounds that select against the tetracycline-resistance efflux pump. Nat Chem Biol. 2016 Nov; 12(11):902-904.Nat Chem Biol2016-09-19T00:00:002016Compounds that select against the tetracycline-resistance efflux pump.Authorship 4360216Authorship 4680505Authorship 49336411Authorship 5060061Authorship 5474461Authorship 5678398Authorship 9333557Authorship 9331401027855786Segev E, Wyche TP, Kim KH, Petersen J, Ellebrandt C, Vlamakis H, Barteneva N, Paulson JN, Chai L, Clardy J, Kolter ReLifeDynamic metabolic exchange governs a marine algal-bacterial interaction. Elife. 2016 11 18; 5.Elife2016-11-18T00:00:002016Dynamic metabolic exchange governs a marine algal-bacterial interaction.27803316Van Arnam EB, Ruzzini AC, Sit CS, Horn H, Pinto-Tomás AA, Currie CR, Clardy JProceedings of the National Academy of Sciences of the United States of AmericaSelvamicin, an atypical antifungal polyene from two alternative genomic contexts. Proc Natl Acad Sci U S A. 2016 11 15; 113(46):12940-12945.Proc Natl Acad Sci U S A2016-11-01T00:00:002016Selvamicin, an atypical antifungal polyene from two alternative genomic contexts.Authorship 938989327906649Garcia DM, Dietrich D, Clardy J, Jarosz DFeLifeA common bacterial metabolite elicits prion-based bypass of glucose repression. Elife. 2016 11 29; 5.Elife2016-11-29T00:00:002016A common bacterial metabolite elicits prion-based bypass of glucose repression.Authorship 2552774Authorship 31724110Authorship 9414406Authorship 9435492Authorship 9434054Authorship 94316426531410Lang HY, Li SZ, McCabe T, Clardy JPlanta medicaA new monoterpene glycoside of Paeonia lactiflora. Planta Med. 1984 Dec; 50(6):501-4.Planta Med1984-12-01T00:00:001984A new monoterpene glycoside of Paeonia lactiflora.27976342Mevers E, Saurí J, Moser A, Varlan M, Martin GE, Clardy JCPlanta medicaChemical warfare: The battle between termite-associated actinobacteria and Trichoderma harzianum, a fungal pathogen. Planta Med. 2016 Dec; 81(S 01):S1-S381.Planta Med2016-12-14T00:00:002016Chemical warfare: The battle between termite-associated actinobacteria and Trichoderma harzianum, a fungal pathogen.4011752Miller RW, Clardy J, Kozlowski J, Mikolajczak KL, Plattner RD, Powell RG, Smith CR, Weisleder D, Zheng QTPlanta medicaPhytoecdysteroids of Diploclisia glaucescens seed. Planta Med. 1985 Feb; (1):40-2.Planta Med1985-02-01T00:00:001985Phytoecdysteroids of Diploclisia glaucescens seed.17340398Miller RW, Clardy J, Kozlowski J, Mikolajczak KL, Plattner RD, Powell RG, Smith CR, Weisleder D, Qi-Tai ZPlanta medicaPhytoecdysteroids of Diploclisia glaucescens Seed. Planta Med. 1985 Feb; 51(1):40-2.Planta Med1985-02-01T00:00:001985Phytoecdysteroids of Diploclisia glaucescens Seed.Authorship 4060659Authorship 4367694Authorship 4696283Authorship 498031Authorship 5054655Authorship 9523891328111075Guo CJ, Chang FY, Wyche TP, Backus KM, Acker TM, Funabashi M, Taketani M, Donia MS, Nayfach S, Pollard KS, Craik CS, Cravatt BF, Clardy J, Voigt CA, Fischbach MACellDiscovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases. Cell. 2017 01 26; 168(3):517-526.e18.Cell2017-01-19T00:00:002017Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases.Authorship 7162428784433Lee JC, Coval SJ, Clardy JThe Journal of antibioticsA cholesteryl ester transfer protein inhibitor from an insect-associated fungus. J Antibiot (Tokyo). 1996 Jul; 49(7):693-6.J Antibiot (Tokyo)1996-07-01T00:00:001996A cholesteryl ester transfer protein inhibitor from an insect-associated fungus.14985Wratten SJ, Faulkner DJ, Hirotsu K, Clardy JJournal of the American Chemical SocietyTrimethylenemethane. A reversible, temperature dependent transformation from higher to lower symmetry as observed by electron spin resonance spectroscopy. J Am Chem Soc. 1977 Apr 13; 99(8):2824-5.J Am Chem Soc1977-04-13T00:00:001977Trimethylenemethane. A reversible, temperature dependent transformation from higher to lower symmetry as observed by electron spin resonance spectroscopy.10574801Bellizzi JJ, Widom J, Kemp CW, Clardy JStructure (London, England : 1993)Producing selenomethionine-labeled proteins with a baculovirus expression vector system. Structure. 1999 Nov 15; 7(11):R263-7.Structure1999-11-15T00:00:001999Producing selenomethionine-labeled proteins with a baculovirus expression vector system.11030999Jiménez JI, Yoshida WY, Scheuer PJ, Lobkovsky E, Clardy J, Kelly MThe Journal of organic chemistryHonulactones: new bishomoscalarane sesterterpenes from the Indonesian sponge Strepsichordaia aliena. J Org Chem. 2000 Oct 20; 65(21):6837-40.J Org Chem2000-10-20T00:00:002000Honulactones: new bishomoscalarane sesterterpenes from the Indonesian sponge Strepsichordaia aliena.11141120Wagenaar MM, Corwin J, Strobel G, Clardy JJournal of natural productsThree new cytochalasins produced by an endophytic fungus in the genus Rhinocladiella. J Nat Prod. 2000 Dec; 63(12):1692-5.J Nat Prod2000-12-01T00:00:002000Three new cytochalasins produced by an endophytic fungus in the genus Rhinocladiella.16168093Clardy JGenome biologyUsing genomics to deliver natural products from symbiotic bacteria. Genome Biol. 2005; 6(9):232.Genome Biol2005-08-31T00:00:002005Using genomics to deliver natural products from symbiotic bacteria.9383421Lee AY, Stewart JD, Clardy J, Ganem BChemistry & biologyNew insight into the catalytic mechanism of chorismate mutases from structural studies. Chem Biol. 1995 Apr; 2(4):195-203.Chem Biol1995-04-01T00:00:001995New insight into the catalytic mechanism of chorismate mutases from structural studies.10673429Liu S, Neidhardt EA, Grossman TH, Ocain T, Clardy JStructure (London, England : 1993)Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents. Structure. 2000 Jan 15; 8(1):25-33.Structure2000-01-15T00:00:002000Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.11583556Brady SF, Bondi SM, Clardy JJournal of the American Chemical SocietyThe guanacastepenes: a highly diverse family of secondary metabolites produced by an endophytic fungus. J Am Chem Soc. 2001 Oct 10; 123(40):9900-1.J Am Chem Soc2001-10-10T00:00:002001The guanacastepenes: a highly diverse family of secondary metabolites produced by an endophytic fungus.11592872Sutton AE, Clardy JJournal of the American Chemical SocietySynthesis and biological evaluation of analogues of the antibiotic pantocin B. J Am Chem Soc. 2001 Oct 17; 123(41):9935-46.J Am Chem Soc2001-10-17T00:00:002001Synthesis and biological evaluation of analogues of the antibiotic pantocin B.9497350Zhang S, Pohnert G, Kongsaeree P, Wilson DB, Clardy J, Ganem BThe Journal of biological chemistryChorismate mutase-prephenate dehydratase from Escherichia coli. Study of catalytic and regulatory domains using genetically engineered proteins. J Biol Chem. 1998 Mar 13; 273(11):6248-53.J Biol Chem1998-03-13T00:00:001998Chorismate mutase-prephenate dehydratase from Escherichia coli. Study of catalytic and regulatory domains using genetically engineered proteins.Authorship 964415226240452Kim KH, Clardy J, Senger D, Cao STetrahedron lettersChakyunglupulins A and B, two novel 4,8,8-trimethylcyclooct-2-enone derivatives from Barleria lupulina. Tetrahedron Lett. 2015 May 20; 56(21):2732-2734.Tetrahedron Lett2015-05-20T00:00:002015Chakyunglupulins A and B, two novel 4,8,8-trimethylcyclooct-2-enone derivatives from Barleria lupulina.11112640Brady SF, Singh MP, Janso JE, Clardy JOrganic lettersCytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus. Org Lett. 2000 Dec 14; 2(25):4047-9.Org Lett2000-12-14T00:00:002000Cytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus.Authorship 9693871128207275Beemelmanns C, Ramadhar TR, Kim KH, Klassen JL, Cao S, Wyche TP, Hou Y, Poulsen M, Bugni TS, Currie CR, Clardy JOrganic lettersMacrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39. Org Lett. 2017 03 03; 19(5):1000-1003.Org Lett2017-02-16T00:00:002017Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39.10447949Jiang J, Li AH, Jang SY, Chang L, Melman N, Moro S, Ji X, Lobkovsky EB, Clardy JC, Jacobson KAJournal of medicinal chemistryChiral resolution and stereospecificity of 6-phenyl-4-phenylethynyl- 1,4-dihydropyridines as selective A(3) adenosine receptor antagonists. J Med Chem. 1999 Aug 12; 42(16):3055-65.J Med Chem1999-08-12T00:00:001999Chiral resolution and stereospecificity of 6-phenyl-4-phenylethynyl- 1,4-dihydropyridines as selective A(3) adenosine receptor antagonists.10450953Moe ST, Shimizu SM, Smith DL, Van Wagenen BC, DelMar EG, Balandrin MF, Chien Y, Raszkiewicz JL, Artman LD, Mueller AL, Lobkovsky E, Clardy JBioorganic & medicinal chemistry lettersSynthesis, biological activity, and absolute stereochemical assignment of NPS 1392: a potent and stereoselective NMDA receptor antagonist. Bioorg Med Chem Lett. 1999 Jul 19; 9(14):1915-20.Bioorg Med Chem Lett1999-07-19T00:00:001999Synthesis, biological activity, and absolute stereochemical assignment of NPS 1392: a potent and stereoselective NMDA receptor antagonist.1517736Ayer WA, Sun M, Browne LM, Brinen LS, Clardy JJournal of natural productsChemical investigation of the metabolites from the Canadian tuckahoe, Polyporus tuberaster. J Nat Prod. 1992 May; 55(5):649-53.J Nat Prod1992-05-01T00:00:001992Chemical investigation of the metabolites from the Canadian tuckahoe, Polyporus tuberaster.17586635Clardy J, Brady SFJournal of bacteriologyCyclic AMP directly activates NasP, an N-acyl amino acid antibiotic biosynthetic enzyme cloned from an uncultured beta-proteobacterium. J Bacteriol. 2007 Sep; 189(17):6487-9.J Bacteriol2007-06-22T00:00:002007Cyclic AMP directly activates NasP, an N-acyl amino acid antibiotic biosynthetic enzyme cloned from an uncultured beta-proteobacterium.17664319Junker LM, Clardy JAntimicrobial agents and chemotherapyHigh-throughput screens for small-molecule inhibitors of Pseudomonas aeruginosa biofilm development. Antimicrob Agents Chemother. 2007 Oct; 51(10):3582-90.Antimicrob Agents Chemother2007-07-30T00:00:002007High-throughput screens for small-molecule inhibitors of Pseudomonas aeruginosa biofilm development.18430569Mazitschek R, Patel V, Wirth DF, Clardy JBioorganic & medicinal chemistry lettersDevelopment of a fluorescence polarization based assay for histone deacetylase ligand discovery. Bioorg Med Chem Lett. 2008 May 01; 18(9):2809-12.Bioorg Med Chem Lett2008-04-07T00:00:002008Development of a fluorescence polarization based assay for histone deacetylase ligand discovery.Authorship 9727551028326787Wyche TP, Ruzzini AC, Beemelmanns C, Kim KH, Klassen JL, Cao S, Poulsen M, Bugni TS, Currie CR, Clardy JOrganic lettersLinear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides. Org Lett. 2017 04 07; 19(7):1772-1775.Org Lett2017-03-22T00:00:002017Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides.11520215Wagenaar MM, Clardy JJournal of natural productsDicerandrols, new antibiotic and cytotoxic dimers produced by the fungus Phomopsis longicolla isolated from an endangered mint. J Nat Prod. 2001 Aug; 64(8):1006-9.J Nat Prod2001-08-01T00:00:002001Dicerandrols, new antibiotic and cytotoxic dimers produced by the fungus Phomopsis longicolla isolated from an endangered mint.11720529Cueto M, Jensen PR, Kauffman C, Fenical W, Lobkovsky E, Clardy JJournal of natural productsPestalone, a new antibiotic produced by a marine fungus in response to bacterial challenge. J Nat Prod. 2001 Nov; 64(11):1444-6.J Nat Prod2001-11-01T00:00:002001Pestalone, a new antibiotic produced by a marine fungus in response to bacterial challenge.15012097Stierle DB, Stierle AA, Hobbs JD, Stokken J, Clardy JOrganic lettersBerkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism. Org Lett. 2004 Mar 18; 6(6):1049-52.Org Lett2004-03-18T00:00:002004Berkeleydione and berkeleytrione, new bioactive metabolites from an acid mine organism.15332842Brady SF, Clardy JJournal of natural productsPalmitoylputrescine, an antibiotic isolated from the heterologous expression of DNA extracted from bromeliad tank water. J Nat Prod. 2004 Aug; 67(8):1283-6.J Nat Prod2004-08-01T00:00:002004Palmitoylputrescine, an antibiotic isolated from the heterologous expression of DNA extracted from bromeliad tank water.15528554Brady SF, Chao CJ, Clardy JApplied and environmental microbiologyLong-chain N-acyltyrosine synthases from environmental DNA. Appl Environ Microbiol. 2004 Nov; 70(11):6865-70.Appl Environ Microbiol2004-11-01T00:00:002004Long-chain N-acyltyrosine synthases from environmental DNA.9846874Nassar N, Hoffman GR, Manor D, Clardy JC, Cerione RANature structural biologyStructures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP. Nat Struct Biol. 1998 Dec; 5(12):1047-52.Nat Struct Biol1998-12-01T00:00:001998Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP.10781062Bellizzi JJ, Widom J, Kemp C, Lu JY, Das AK, Hofmann SL, Clardy JProceedings of the National Academy of Sciences of the United States of AmericaThe crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4573-8.Proc Natl Acad Sci U S A2000-04-25T00:00:002000The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis.11859078Nonato MC, Widom J, Clardy JThe Journal of biological chemistryCrystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha. J Biol Chem. 2002 May 10; 277(19):17057-61.J Biol Chem2002-02-21T00:00:002002Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha.12538866Sinars CR, Cheung-Flynn J, Rimerman RA, Scammell JG, Smith DF, Clardy JProceedings of the National Academy of Sciences of the United States of AmericaStructure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):868-73.Proc Natl Acad Sci U S A2003-01-21T00:00:002003Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes.Authorship 975056628385960Liu Y, Saurí J, Mevers E, Peczuh MW, Hiemstra H, Clardy J, Martin GE, Williamson RTScience (New York, N.Y.)Unequivocal determination of complex molecular structures using anisotropic NMR measurements. Science. 2017 04 07; 356(6333).Science2017-04-07T00:00:002017Unequivocal determination of complex molecular structures using anisotropic NMR measurements.16928075Maloney KN, Hao W, Xu J, Gibbons J, Hucul J, Roll D, Brady SF, Schroeder FC, Clardy JOrganic lettersPhaeosphaeride A, an inhibitor of STAT3-dependent signaling isolated from an endophytic fungus. Org Lett. 2006 Aug 31; 8(18):4067-70.Org Lett2006-08-31T00:00:002006Phaeosphaeride A, an inhibitor of STAT3-dependent signaling isolated from an endophytic fungus.16562836Thammana S, Suzuki H, Lobkovsky E, Clardy J, Shimizu YJournal of natural productsIsolation and structure assignment of an iminotetrasaccharide from a cultured filamentous cyanobacterium Anabaena sp. J Nat Prod. 2006 Mar; 69(3):365-8.J Nat Prod2006-03-01T00:00:002006Isolation and structure assignment of an iminotetrasaccharide from a cultured filamentous cyanobacterium Anabaena sp.17160060Clardy J, Fischbach MA, Walsh CTNature biotechnologyNew antibiotics from bacterial natural products. Nat Biotechnol. 2006 Dec; 24(12):1541-50.Nat Biotechnol2006-12-01T00:00:002006New antibiotics from bacterial natural products.10089303Liang J, Choi J, Clardy JActa crystallographica. Section D, Biological crystallographyRefined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution. Acta Crystallogr D Biol Crystallogr. 1999 Apr; 55(Pt 4):736-44.Acta Crystallogr D Biol Crystallogr1999-04-01T00:00:001999Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.8831972Zhang S, Kongsaeree P, Clardy J, Wilson DB, Ganem BBioorganic & medicinal chemistrySite-directed mutagenesis of monofunctional chorismate mutase engineered from the E. coli P-protein. Bioorg Med Chem. 1996 Jul; 4(7):1015-20.Bioorg Med Chem1996-07-01T00:00:001996Site-directed mutagenesis of monofunctional chorismate mutase engineered from the E. coli P-protein.11513043Wagenaar MM, Clardy JThe Journal of antibioticsTwo new roridins isolated from Myrothecium sp. J Antibiot (Tokyo). 2001 Jun; 54(6):517-20.J Antibiot (Tokyo)2001-06-01T00:00:002001Two new roridins isolated from Myrothecium sp.11975510Anjaneyulu AS, Rao VL, Lobkovsky E, Clardy JJournal of natural productsCeriopsin E, a new epoxy ent-kaurene diterpenoid from Ceriops decandra. J Nat Prod. 2002 Apr; 65(4):592-4.J Nat Prod2002-04-01T00:00:002002Ceriopsin E, a new epoxy ent-kaurene diterpenoid from Ceriops decandra.20861892Crawford JM, Clardy JNature chemistryBiosynthesis: not just passing through. Nat Chem. 2010 Oct; 2(10):805-7.Nat Chem2010-10-01T00:00:002010Biosynthesis: not just passing through.21594283Crawford JM, Clardy JChemical communications (Cambridge, England)Bacterial symbionts and natural products. Chem Commun (Camb). 2011 Jul 21; 47(27):7559-66.Chem Commun (Camb)2011-05-19T00:00:002011Bacterial symbionts and natural products.12188643Brady SF, Chao CJ, Clardy JJournal of the American Chemical SocietyNew natural product families from an environmental DNA (eDNA) gene cluster. J Am Chem Soc. 2002 Aug 28; 124(34):9968-9.J Am Chem Soc2002-08-28T00:00:002002New natural product families from an environmental DNA (eDNA) gene cluster.1709302Van Duyne GD, Standaert RF, Karplus PA, Schreiber SL, Clardy JScience (New York, N.Y.)Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex. Science. 1991 May 10; 252(5007):839-42.Science1991-05-10T00:00:001991Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex.17125221Amagata T, Morinaka BI, Amagata A, Tenney K, Valeriote FA, Lobkovsky E, Clardy J, Crews PJournal of natural productsA chemical study of cyclic depsipeptides produced by a sponge-derived fungus. J Nat Prod. 2006 Nov; 69(11):1560-5.J Nat Prod2006-11-01T00:00:002006A chemical study of cyclic depsipeptides produced by a sponge-derived fungus.15844952Schroeder FC, Kau TR, Silver PA, Clardy JJournal of natural productsThe psammaplysenes, specific inhibitors of FOXO1a nuclear export. J Nat Prod. 2005 Apr; 68(4):574-6.J Nat Prod2005-04-01T00:00:002005The psammaplysenes, specific inhibitors of FOXO1a nuclear export.16146359Georgiades SN, Clardy JOrganic lettersTotal synthesis of psammaplysenes A and B, naturally occurring inhibitors of FOXO1a nuclear export. Org Lett. 2005 Sep 15; 7(19):4091-4.Org Lett2005-09-15T00:00:002005Total synthesis of psammaplysenes A and B, naturally occurring inhibitors of FOXO1a nuclear export.8931719Schroeder DR, Colson KL, Klohr SE, Lee MS, Matson JA, Brinen LS, Clardy JThe Journal of antibioticsPyrrolosporin A, a new antitumor antibiotic from Micromonospora sp. C39217-R109-7. II. Isolation, physico-chemical properties, spectroscopic study and X-ray analysis. J Antibiot (Tokyo). 1996 Sep; 49(9):865-72.J Antibiot (Tokyo)1996-09-01T00:00:001996Pyrrolosporin A, a new antitumor antibiotic from Micromonospora sp. C39217-R109-7. II. Isolation, physico-chemical properties, spectroscopic study and X-ray analysis.17983747Georgiades SN, Clardy JBioorganic & medicinal chemistry lettersSynthetic libraries of tyrosine-derived bacterial metabolites. Bioorg Med Chem Lett. 2008 May 15; 18(10):3117-21.Bioorg Med Chem Lett2007-10-22T00:00:002007Synthetic libraries of tyrosine-derived bacterial metabolites.9818143Handelsman J, Rondon MR, Brady SF, Clardy J, Goodman RMChemistry & biologyMolecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products. Chem Biol. 1998 Oct; 5(10):R245-9.Chem Biol1998-10-01T00:00:001998Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products.11418029Brady SF, Chao CJ, Handelsman J, Clardy JOrganic lettersCloning and heterologous expression of a natural product biosynthetic gene cluster from eDNA. Org Lett. 2001 Jun 28; 3(13):1981-4.Org Lett2001-06-28T00:00:002001Cloning and heterologous expression of a natural product biosynthetic gene cluster from eDNA.12855696Calero G, Gupta P, Nonato MC, Tandel S, Biehl ER, Hofmann SL, Clardy JThe Journal of biological chemistryThe crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2. J Biol Chem. 2003 Sep 26; 278(39):37957-64.J Biol Chem2003-07-10T00:00:002003The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2.19307367Rush MA, Baniecki ML, Mazitschek R, Cortese JF, Wiegand R, Clardy J, Wirth DFAntimicrobial agents and chemotherapyColorimetric high-throughput screen for detection of heme crystallization inhibitors. Antimicrob Agents Chemother. 2009 Jun; 53(6):2564-8.Antimicrob Agents Chemother2009-03-23T00:00:002009Colorimetric high-throughput screen for detection of heme crystallization inhibitors.17197182Martyn DC, Jones DC, Fairlamb AH, Clardy JBioorganic & medicinal chemistry lettersHigh-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. Bioorg Med Chem Lett. 2007 Mar 01; 17(5):1280-3.Bioorg Med Chem Lett2006-12-09T00:00:002006High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity.20524642Kontnik R, Crawford JM, Clardy JACS chemical biologyExploiting a global regulator for small molecule discovery in Photorhabdus luminescens. ACS Chem Biol. 2010 Jul 16; 5(7):659-65.ACS Chem Biol2010-07-16T00:00:002010Exploiting a global regulator for small molecule discovery in Photorhabdus luminescens.21348461Marks KM, Park ES, Arefolov A, Russo K, Ishihara K, Ring JE, Clardy J, Clarke AS, Pelish HEJournal of natural productsThe selectivity of austocystin D arises from cell-line-specific drug activation by cytochrome P450 enzymes. J Nat Prod. 2011 Apr 25; 74(4):567-73.J Nat Prod2011-02-24T00:00:002011The selectivity of austocystin D arises from cell-line-specific drug activation by cytochrome P450 enzymes.15038793Candi E, Paradisi A, Terrinoni A, Pietroni V, Oddi S, Cadot B, Jogini V, Meiyappan M, Clardy J, Finazzi-Agro A, Melino GThe Biochemical journalTransglutaminase 5 is regulated by guanine-adenine nucleotides. Biochem J. 2004 Jul 01; 381(Pt 1):313-9.Biochem J2004-07-01T00:00:002004Transglutaminase 5 is regulated by guanine-adenine nucleotides.15602548Clardy J, Walsh CNatureLessons from natural molecules. Nature. 2004 Dec 16; 432(7019):829-37.Nature2004-12-16T00:00:002004Lessons from natural molecules.12662106Garo E, Starks CM, Jensen PR, Fenical W, Lobkovsky E, Clardy JJournal of natural productsTrichodermamides A and B, cytotoxic modified dipeptides from the marine-derived fungus Trichoderma virens. J Nat Prod. 2003 Mar; 66(3):423-6.J Nat Prod2003-03-01T00:00:002003Trichodermamides A and B, cytotoxic modified dipeptides from the marine-derived fungus Trichoderma virens.14602008Amagata T, Amagata A, Tenney K, Valeriote FA, Lobkovsky E, Clardy J, Crews POrganic lettersUnusual C25 steroids produced by a sponge-derived Penicillium citrinum. Org Lett. 2003 Nov 13; 5(23):4393-6.Org Lett2003-11-13T00:00:002003Unusual C25 steroids produced by a sponge-derived Penicillium citrinum.15982051Weibel DB, Lee A, Mayer M, Brady SF, Bruzewicz D, Yang J, Diluzio WR, Clardy J, Whitesides GMLangmuir : the ACS journal of surfaces and colloidsBacterial printing press that regenerates its ink: contact-printing bacteria using hydrogel stamps. Langmuir. 2005 Jul 05; 21(14):6436-42.Langmuir2005-07-05T00:00:002005Bacterial printing press that regenerates its ink: contact-printing bacteria using hydrogel stamps.16406782Hurt DE, Sutton AE, Clardy JBioorganic & medicinal chemistry lettersBrequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase. Bioorg Med Chem Lett. 2006 Mar 15; 16(6):1610-5.Bioorg Med Chem Lett2006-01-10T00:00:002006Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.2133090LaLonde RT, Perakyla H, Ishiguro Y, Clardy J, Brinen LSChemical research in toxicologyStructure of an anhydride related to a mutagenic component of drinking water, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone. Chem Res Toxicol. 1990 Sep-Oct; 3(5):404-5.Chem Res Toxicol1990-09-01T00:00:001990Structure of an anhydride related to a mutagenic component of drinking water, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone.9170290Nasreen A, Akhtar F, Shekhani MS, Clardy J, Parvez M, Choudhary MIJournal of natural productsAntifungal diterpenoid alkaloids from Delphinium denudatum. J Nat Prod. 1997 May; 60(5):472-4.J Nat Prod1997-05-01T00:00:001997Antifungal diterpenoid alkaloids from Delphinium denudatum.9636050Lee AY, Zhang S, Kongsaeree P, Clardy J, Ganem B, Erickson JW, Xie DBiochemistryThermodynamics of a transition state analogue inhibitor binding to Escherichia coli chorismate mutase: probing the charge state of an active site residue and its role in inhibitor binding and catalysis. Biochemistry. 1998 Jun 23; 37(25):9052-7.Biochemistry1998-06-23T00:00:001998Thermodynamics of a transition state analogue inhibitor binding to Escherichia coli chorismate mutase: probing the charge state of an active site residue and its role in inhibitor binding and catalysis.9812898Liu S, Widom J, Kemp CW, Crews CM, Clardy JScience (New York, N.Y.)Structure of human methionine aminopeptidase-2 complexed with fumagillin. Science. 1998 Nov 13; 282(5392):1324-7.Science1998-11-13T00:00:001998Structure of human methionine aminopeptidase-2 complexed with fumagillin.10051553Clardy JProceedings of the National Academy of Sciences of the United States of AmericaBorrowing to make ends meet. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):1826-7.Proc Natl Acad Sci U S A1999-03-02T00:00:001999Borrowing to make ends meet.15299748Liang J, Ealick S, Nielsen C, Schreiber SL, Clardy JActa crystallographica. Section D, Biological crystallographyCrystallization and preliminary X-ray analysis of twinned crystals of a chimeric FK506 binding protein 12 and 13 complexed with FK506. Acta Crystallogr D Biol Crystallogr. 1996 Jan 01; 52(Pt 1):207-10.Acta Crystallogr D Biol Crystallogr1996-01-01T00:00:001996Crystallization and preliminary X-ray analysis of twinned crystals of a chimeric FK506 binding protein 12 and 13 complexed with FK506.1955886Alvi KA, Abbas SA, Sultana T, Shameel M, Choudhary MI, Clardy JCJournal of natural productsA diterpenoid lactone from Aplysia juliana. J Nat Prod. 1991 May-Jun; 54(3):886-8.J Nat Prod1991-05-01T00:00:001991A diterpenoid lactone from Aplysia juliana.9214728Jaspars M, Jackson E, Lobkovsky E, Clardy J, Diaz MC, Crews PJournal of natural productsUsing scalarane sesterterpenes to examine a sponge taxonomic anomaly. J Nat Prod. 1997 Jun; 60(6):556-61.J Nat Prod1997-06-01T00:00:001997Using scalarane sesterterpenes to examine a sponge taxonomic anomaly.9917313Gunasekera SP, McCarthy PJ, Longley RE, Pomponi SA, Wright AE, Lobkovsky E, Clardy JJournal of natural productsDiscorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella. J Nat Prod. 1999 Jan; 62(1):173-5.J Nat Prod1999-01-01T00:00:001999Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella.10075544Qiu SX, Sun HD, Lobkovsky E, Chai H, Clardy J, Farnsworth NR, Pezzuto JM, Fong HHPlanta medicaMegathyrin B: a cytotoxic diterpene from Isodon megathyrsus. Planta Med. 1998 Dec; 64(8):728-31.Planta Med1998-12-01T00:00:001998Megathyrin B: a cytotoxic diterpene from Isodon megathyrsus.10831436Rondon MR, August PR, Bettermann AD, Brady SF, Grossman TH, Liles MR, Loiacono KA, Lynch BA, MacNeil IA, Minor C, Tiong CL, Gilman M, Osburne MS, Clardy J, Handelsman J, Goodman RMApplied and environmental microbiologyCloning the soil metagenome: a strategy for accessing the genetic and functional diversity of uncultured microorganisms. Appl Environ Microbiol. 2000 Jun; 66(6):2541-7.Appl Environ Microbiol2000-06-01T00:00:002000Cloning the soil metagenome: a strategy for accessing the genetic and functional diversity of uncultured microorganisms.19797623Kim K, Sato K, Shibuya M, Zeiger DM, Butcher RA, Ragains JR, Clardy J, Touhara K, Sengupta PScience (New York, N.Y.)Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegans. Science. 2009 Nov 13; 326(5955):994-8.Science2009-10-01T00:00:002009Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegans.23249812Chandler JR, Truong TT, Silva PM, Seyedsayamdost MR, Carr G, Radey M, Jacobs MA, Sims EH, Clardy J, Greenberg EPmBioBactobolin resistance is conferred by mutations in the L2 ribosomal protein. mBio. 2012 Dec 18; 3(6).mBio2012-12-18T00:00:002012Bactobolin resistance is conferred by mutations in the L2 ribosomal protein.19317450Patel V, Mazitschek R, Coleman B, Nguyen C, Urgaonkar S, Cortese J, Barker RH, Greenberg E, Tang W, Bradner JE, Schreiber SL, Duraisingh MT, Wirth DF, Clardy JJournal of medicinal chemistryIdentification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. J Med Chem. 2009 Apr 23; 52(8):2185-7.J Med Chem2009-04-23T00:00:002009Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.23538827Stallforth P, Clardy JNatureX-ray crystallography: One size fits most. Nature. 2013 Mar 28; 495(7442):456-7.Nature2013-03-28T00:00:002013X-ray crystallography: One size fits most.21378864Miller SJ, Clardy JNature chemistryNatural products: Beyond grind and find. Nat Chem. 2009 Jul; 1(4):261-3.Nat Chem2009-07-01T00:00:002009Natural products: Beyond grind and find.21699219Seyedsayamdost MR, Traxler MF, Zheng SL, Kolter R, Clardy JJournal of the American Chemical SocietyStructure and biosynthesis of amychelin, an unusual mixed-ligand siderophore from Amycolatopsis sp. AA4. J Am Chem Soc. 2011 Aug 03; 133(30):11434-7.J Am Chem Soc2011-07-07T00:00:002011Structure and biosynthesis of amychelin, an unusual mixed-ligand siderophore from Amycolatopsis sp. AA4.2045819Powell RG, Mikolajczak KL, Zilkowski BW, Mantus EK, Cherry D, Clardy JJournal of natural productsLimonoid antifeedants from seed of Sandoricum koetjape. J Nat Prod. 1991 Jan-Feb; 54(1):241-6.J Nat Prod1991-01-01T00:00:001991Limonoid antifeedants from seed of Sandoricum koetjape.17183517Schroeder FC, Gibson DM, Churchill AC, Sojikul P, Wursthorn EJ, Krasnoff SB, Clardy JAngewandte Chemie (International ed. in English)Differential analysis of 2D NMR spectra: new natural products from a pilot-scale fungal extract library. Angew Chem Int Ed Engl. 2007; 46(6):901-4.Angew Chem Int Ed Engl2007-01-01T00:00:002007Differential analysis of 2D NMR spectra: new natural products from a pilot-scale fungal extract library.18216259Fischbach MA, Walsh CT, Clardy JProceedings of the National Academy of Sciences of the United States of AmericaThe evolution of gene collectives: How natural selection drives chemical innovation. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4601-8.Proc Natl Acad Sci U S A2008-01-23T00:00:002008The evolution of gene collectives: How natural selection drives chemical innovation.19553463Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, Zhou W, Liu Y, Neve RL, Taylor JP, Driscoll M, Clardy J, Merry D, Kalb RGThe Journal of neuroscience : the official journal of the Society for NeuroscienceFOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. J Neurosci. 2009 Jun 24; 29(25):8236-47.J Neurosci2009-06-24T00:00:002009FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases.19810733Cronan JM, Lee A, Liang J, Clardy J, Cardellina JHJournal of natural productsChemical modification of the insecticidal briantheins X and Y. J Nat Prod. 2010 Mar 26; 73(3):346-51.J Nat Prod2010-03-26T00:00:002010Chemical modification of the insecticidal briantheins X and Y.7473578Concepción GP, Foderaro TA, Eldredge GS, Lobkovsky E, Clardy J, Barrows LR, Ireland CMJournal of medicinal chemistryTopoisomerase II-mediated DNA cleavage by adocia- and xestoquinones from the Philippine sponge Xestospongia sp. J Med Chem. 1995 Oct 27; 38(22):4503-7.J Med Chem1995-10-27T00:00:001995Topoisomerase II-mediated DNA cleavage by adocia- and xestoquinones from the Philippine sponge Xestospongia sp.1133383Schantz EJ, Ghazarossian VE, Schnoes HK, Strong FM, Springer JP, Pezzanite JO, Clardy JJournal of the American Chemical SocietyLetter: The structure of saxitoxin. J Am Chem Soc. 1975 Mar 05; 97(5):1238.J Am Chem Soc1975-03-05T00:00:001975Letter: The structure of saxitoxin.19523825Yuan H, Pupo MT, Blois J, Smith A, Weissleder R, Clardy J, Josephson LBioorganic & medicinal chemistry lettersA stabilized demethoxyviridin derivative inhibits PI3 kinase. Bioorg Med Chem Lett. 2009 Aug 01; 19(15):4223-7.Bioorg Med Chem Lett2009-05-30T00:00:002009A stabilized demethoxyviridin derivative inhibits PI3 kinase.19914064Martyn DC, Nijjar A, Celatka CA, Mazitschek R, Cortese JF, Tyndall E, Liu H, Fitzgerald MM, O'Shea TJ, Danthi S, Clardy JBioorganic & medicinal chemistry lettersSynthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines. Bioorg Med Chem Lett. 2010 Jan 01; 20(1):228-31.Bioorg Med Chem Lett2009-10-31T00:00:002009Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines.19914069Martyn DC, Cortese JF, Tyndall E, Dick J, Mazitschek R, Munoz B, Clardy JBioorganic & medicinal chemistry lettersAntiplasmodial activity of piperazine sulfonamides. Bioorg Med Chem Lett. 2010 Jan 01; 20(1):218-21.Bioorg Med Chem Lett2009-10-31T00:00:002009Antiplasmodial activity of piperazine sulfonamides.22195562Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH, Dvorin JD, Duraisingh MT, Wirth DF, Clardy J, Mazitschek RChemistry & biologyIdentification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chem Biol. 2011 Dec 23; 18(12):1602-10.Chem Biol2011-12-23T00:00:002011Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.21420479Harris ES, Erickson SD, Tolopko AN, Cao S, Craycroft JA, Scholten R, Fu Y, Wang W, Liu Y, Zhao Z, Clardy J, Shamu CE, Eisenberg DMJournal of ethnopharmacologyTraditional Medicine Collection Tracking System (TM-CTS): a database for ethnobotanically driven drug-discovery programs. J Ethnopharmacol. 2011 May 17; 135(2):590-3.J Ethnopharmacol2011-03-21T00:00:002011Traditional Medicine Collection Tracking System (TM-CTS): a database for ethnobotanically driven drug-discovery programs.Authorship 10016903Authorship 10057245Authorship 1006782628853867Wyche TP, Ruzzini AC, Schwab L, Currie CR, Clardy JJournal of the American Chemical SocietyTryptorubin A: A Polycyclic Peptide from a Fungus-Derived Streptomycete. J Am Chem Soc. 2017 09 20; 139(37):12899-12902.J Am Chem Soc2017-09-06T00:00:002017Tryptorubin A: A Polycyclic Peptide from a Fungus-Derived Streptomycete.28745342Van Arnam EB, Currie CR, Clardy JChemical Society reviewsDefense contracts: molecular protection in insect-microbe symbioses. Chem Soc Rev. 2018 Mar 05; 47(5):1638-1651.Chem Soc Rev2018-03-05T00:00:002018Defense contracts: molecular protection in insect-microbe symbioses.28783126Boccitto M, Lee N, Sakamoto S, Spruce LA, Handa H, Clardy J, Seeholzer SH, Kalb RGMarine drugsThe Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK. Mar Drugs. 2017 Aug 07; 15(8).Mar Drugs2017-08-07T00:00:002017The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK.2021-07-31CLARDY, JON2008-09-09Chemical biology of bacterial symbiontsR01AT0098742021-03-31CLARDY, JON2017-04-01Identification and characterization of gut microbial bioactive molecules that determine predisposition to autoimmune disease and atopyR01AT009708Principal InvestigatorPrincipal Investigator4414095Boeckman RK, Fayos J, Clardy JJournal of the American Chemical SocietyLetter: A revised structure of vermiculine. A novel macrolide dilactone antibiotic from Penicillium vermiculatum. J Am Chem Soc. 1974 Sep 04; 96(18):5954-6.J Am Chem Soc1974-09-04T00:00:001974Letter: A revised structure of vermiculine. A novel macrolide dilactone antibiotic from Penicillium vermiculatum.21364940Poulsen M, Oh DC, Clardy J, Currie CRPloS oneChemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery. PLoS One. 2011 Feb 22; 6(2):e16763.PLoS One2011-02-22T00:00:002011Chemical analyses of wasp-associated streptomyces bacteria reveal a prolific potential for natural products discovery.21824641Harris ES, Cao S, Littlefield BA, Craycroft JA, Scholten R, Kaptchuk T, Fu Y, Wang W, Liu Y, Chen H, Zhao Z, Clardy J, Woolf AD, Eisenberg DMThe Science of the total environmentHeavy metal and pesticide content in commonly prescribed individual raw Chinese Herbal Medicines. Sci Total Environ. 2011 Sep 15; 409(20):4297-305.Sci Total Environ2011-08-06T00:00:002011Heavy metal and pesticide content in commonly prescribed individual raw Chinese Herbal Medicines.21888371Crawford JM, Portmann C, Kontnik R, Walsh CT, Clardy JOrganic lettersNRPS substrate promiscuity diversifies the xenematides. Org Lett. 2011 Oct 07; 13(19):5144-7.Org Lett2011-09-02T00:00:002011NRPS substrate promiscuity diversifies the xenematides.893894Howard BM, Fenical W, Finer J, Hirotsu K, Clardy JJournal of the American Chemical SocietyNeoconcinndiol hydroperoxide, a novel marine diterpenoid from the red alga Laurencia. J Am Chem Soc. 1977 Sep 14; 99(19):6440-1.J Am Chem Soc1977-09-14T00:00:001977Neoconcinndiol hydroperoxide, a novel marine diterpenoid from the red alga Laurencia.7529414Clardy JProceedings of the National Academy of Sciences of the United States of AmericaThe chemistry of signal transduction. Proc Natl Acad Sci U S A. 1995 Jan 03; 92(1):56-61.Proc Natl Acad Sci U S A1995-01-03T00:00:001995The chemistry of signal transduction.8648629Liang J, Chen JK, Schreiber ST, Clardy JJournal of molecular biologyCrystal structure of P13K SH3 domain at 20 angstroms resolution. J Mol Biol. 1996 Apr 05; 257(3):632-43.J Mol Biol1996-04-05T00:00:001996Crystal structure of P13K SH3 domain at 20 angstroms resolution.9383379Lee AY, Smitka TA, Bonjouklian R, Clardy JChemistry & biologyAtomic structure of the trypsin-A90720A complex: a unified approach to structure and function. Chem Biol. 1994 Oct; 1(2):113-7.Chem Biol1994-10-01T00:00:001994Atomic structure of the trypsin-A90720A complex: a unified approach to structure and function.11076576Brady SF, Clardy JJournal of natural productsCR377, a new pentaketide antifungal agent isolated from an endophytic fungus. J Nat Prod. 2000 Oct; 63(10):1447-8.J Nat Prod2000-10-01T00:00:002000CR377, a new pentaketide antifungal agent isolated from an endophytic fungus.Authorship 10105964Authorship 1010132628893599Guo H, Rischer M, Sperfeld M, Weigel C, Menzel KD, Clardy J, Beemelmanns CBioorganic & medicinal chemistryNatural products and morphogenic activity of ?-Proteobacteria associated with the marine hydroid polyp Hydractinia echinata. Bioorg Med Chem. 2017 11 15; 25(22):6088-6097.Bioorg Med Chem2017-07-01T00:00:002017Natural products and morphogenic activity of ?-Proteobacteria associated with the marine hydroid polyp Hydractinia echinata.28867285Woznica A, Gerdt JP, Hulett RE, Clardy J, King NCellMating in the Closest Living Relatives of Animals Is Induced by a Bacterial Chondroitinase. Cell. 2017 Sep 07; 170(6):1175-1183.e11.Cell2017-08-31T00:00:002017Mating in the Closest Living Relatives of Animals Is Induced by a Bacterial Chondroitinase.12000277Salomon CE, Williams DH, Lobkovsky E, Clardy JC, Faulkner DJOrganic lettersRelative and absolute stereochemistry of the didemnaketals, metabolites of a Palauan ascidian, Didemnum sp. Org Lett. 2002 May 16; 4(10):1699-702.Org Lett2002-05-16T00:00:002002Relative and absolute stereochemistry of the didemnaketals, metabolites of a Palauan ascidian, Didemnum sp.12608855Amagata T, Whitman S, Johnson TA, Stessman CC, Loo CP, Lobkovsky E, Clardy J, Crews P, Holman TRJournal of natural productsExploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb; 66(2):230-5.J Nat Prod2003-02-01T00:00:002003Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases.18698786Kontnik R, Clardy JOrganic lettersCodinaeopsin, an antimalarial fungal polyketide. Org Lett. 2008 Sep 18; 10(18):4149-51.Org Lett2008-08-13T00:00:002008Codinaeopsin, an antimalarial fungal polyketide.19995983Lomenick B, Hao R, Jonai N, Chin RM, Aghajan M, Warburton S, Wang J, Wu RP, Gomez F, Loo JA, Wohlschlegel JA, Vondriska TM, Pelletier J, Herschman HR, Clardy J, Clarke CF, Huang JProceedings of the National Academy of Sciences of the United States of AmericaTarget identification using drug affinity responsive target stability (DARTS). Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21984-9.Proc Natl Acad Sci U S A2009-12-07T00:00:002009Target identification using drug affinity responsive target stability (DARTS).21944749Crawford JM, Mahlstedt SA, Malcolmson SJ, Clardy J, Walsh CTChemistry & biologyDihydrophenylalanine: a prephenate-derived Photorhabdus luminescens antibiotic and intermediate in dihydrostilbene biosynthesis. Chem Biol. 2011 Sep 23; 18(9):1102-12.Chem Biol2011-09-23T00:00:002011Dihydrophenylalanine: a prephenate-derived Photorhabdus luminescens antibiotic and intermediate in dihydrostilbene biosynthesis.22591554Carr G, Poulsen M, Klassen JL, Hou Y, Wyche TP, Bugni TS, Currie CR, Clardy JOrganic lettersMicrotermolides A and B from termite-associated Streptomyces sp. and structural revision of vinylamycin. Org Lett. 2012 Jun 01; 14(11):2822-5.Org Lett2012-05-16T00:00:002012Microtermolides A and B from termite-associated Streptomyces sp. and structural revision of vinylamycin.6980283Kaiser C, Dandridge PA, Garvey E, Hahn RA, Sarau HM, Setler PE, Bass LS, Clardy JJournal of medicinal chemistryAbsolute stereochemistry and dopaminergic activity of enantiomers of 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine. J Med Chem. 1982 Jun; 25(6):697-703.J Med Chem1982-06-01T00:00:001982Absolute stereochemistry and dopaminergic activity of enantiomers of 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine.965639Prestwich GD, Tanis SP, Springer JP, Clardy JJournal of the American Chemical SocietyLetter: Nasute termite soldier frontal gland secretions. 1. Structure of trinervi-2 beta, 3 alpha, 9 alpha-triol 9-o-acetate, a novel diterpene fromTrinervitermes soldiers. J Am Chem Soc. 1976 Sep 15; 98(19):6061-2.J Am Chem Soc1976-09-15T00:00:001976Letter: Nasute termite soldier frontal gland secretions. 1. Structure of trinervi-2 beta, 3 alpha, 9 alpha-triol 9-o-acetate, a novel diterpene fromTrinervitermes soldiers.12434151Calero G, Wilson KF, Ly T, Rios-Steiner JL, Clardy JC, Cerione RANature structural biologyStructural basis of m7GpppG binding to the nuclear cap-binding protein complex. Nat Struct Biol. 2002 Dec; 9(12):912-7.Nat Struct Biol2002-12-01T00:00:002002Structural basis of m7GpppG binding to the nuclear cap-binding protein complex.16217820Brady SF, Clardy JAngewandte Chemie (International ed. in English)Systematic investigation of the Escherichia coli metabolome for the biosynthetic origin of an isocyanide carbon atom. Angew Chem Int Ed Engl. 2005 Nov 04; 44(43):7045-8.Angew Chem Int Ed Engl2005-11-04T00:00:002005Systematic investigation of the Escherichia coli metabolome for the biosynthetic origin of an isocyanide carbon atom.16510978Hurt DE, Widom J, Clardy JActa crystallographica. Section D, Biological crystallographyStructure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor. Acta Crystallogr D Biol Crystallogr. 2006 Mar; 62(Pt 3):312-23.Acta Crystallogr D Biol Crystallogr2006-02-22T00:00:002006Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor.16540317Nonato MC, Widom J, Clardy JBioorganic & medicinal chemistry lettersHuman methionine aminopeptidase type 2 in complex with L- and D-methionine. Bioorg Med Chem Lett. 2006 May 15; 16(10):2580-3.Bioorg Med Chem Lett2006-03-15T00:00:002006Human methionine aminopeptidase type 2 in complex with L- and D-methionine.16910643Jin M, Fischbach MA, Clardy JJournal of the American Chemical SocietyA biosynthetic gene cluster for the acetyl-CoA carboxylase inhibitor andrimid. J Am Chem Soc. 2006 Aug 23; 128(33):10660-1.J Am Chem Soc2006-08-23T00:00:002006A biosynthetic gene cluster for the acetyl-CoA carboxylase inhibitor andrimid.16956199Georgiades SN, Clardy JOrganic lettersPreparation of a psammaplysene-based library. Org Lett. 2006 Sep 14; 8(19):4251-4.Org Lett2006-09-14T00:00:002006Preparation of a psammaplysene-based library.17576415Fischbach MA, Clardy JNature chemical biologyOne pathway, many products. Nat Chem Biol. 2007 Jul; 3(7):353-5.Nat Chem Biol2007-07-01T00:00:002007One pathway, many products.19174521Butcher RA, Ragains JR, Li W, Ruvkun G, Clardy J, Mak HYProceedings of the National Academy of Sciences of the United States of AmericaBiosynthesis of the Caenorhabditis elegans dauer pheromone. Proc Natl Acad Sci U S A. 2009 Feb 10; 106(6):1875-9.Proc Natl Acad Sci U S A2009-01-27T00:00:002009Biosynthesis of the Caenorhabditis elegans dauer pheromone.19699641Martyn DC, Beletsky G, Cortese JF, Tyndall E, Liu H, Fitzgerald MM, O'Shea TJ, Liang B, Clardy JBioorganic & medicinal chemistry lettersSynthesis and in vitro DMPK profiling of a 1,2-dioxolane-based library with activity against Plasmodium falciparum. Bioorg Med Chem Lett. 2009 Oct 01; 19(19):5657-60.Bioorg Med Chem Lett2009-08-08T00:00:002009Synthesis and in vitro DMPK profiling of a 1,2-dioxolane-based library with activity against Plasmodium falciparum.21108995Eisenberg DM, Harris ES, Littlefield BA, Cao S, Craycroft JA, Scholten R, Bayliss P, Fu Y, Wang W, Qiao Y, Zhao Z, Chen H, Liu Y, Kaptchuk T, Hahn WC, Wang X, Roberts T, Shamu CE, Clardy JFitoterapiaDeveloping a library of authenticated Traditional Chinese Medicinal (TCM) plants for systematic biological evaluation--rationale, methods and preliminary results from a Sino-American collaboration. Fitoterapia. 2011 Jan; 82(1):17-33.Fitoterapia2010-11-22T00:00:002010Developing a library of authenticated Traditional Chinese Medicinal (TCM) plants for systematic biological evaluation--rationale, methods and preliminary results from a Sino-American collaboration.21422215Barker RH, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman BI, Angulo-Barturen I, Jiménez-Díaz MB, Magán N, Gomez V, Ferrer S, Martínez MS, Wittlin S, Papastogiannidis P, O'Shea T, Klinger JD, Bree M, Lee E, Levine M, Wiegand RC, Munoz B, Wirth DF, Clardy J, Bathurst I, Sybertz EAntimicrobial agents and chemotherapyAminoindoles, a novel scaffold with potent activity against Plasmodium falciparum. Antimicrob Agents Chemother. 2011 Jun; 55(6):2612-22.Antimicrob Agents Chemother2011-03-21T00:00:002011Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.22931126Traxler MF, Seyedsayamdost MR, Clardy J, Kolter RMolecular microbiologyInterspecies modulation of bacterial development through iron competition and siderophore piracy. Mol Microbiol. 2012 Nov; 86(3):628-44.Mol Microbiol2012-09-11T00:00:002012Interspecies modulation of bacterial development through iron competition and siderophore piracy.23071628Adler C, Corbalán NS, Seyedsayamdost MR, Pomares MF, de Cristóbal RE, Clardy J, Kolter R, Vincent PAPloS oneCatecholate siderophores protect bacteria from pyochelin toxicity. PLoS One. 2012; 7(10):e46754.PLoS One2012-10-05T00:00:002012Catecholate siderophores protect bacteria from pyochelin toxicity.14986973Sonnenschein RN, Farias JJ, Tenney K, Mooberry SL, Lobkovsky E, Clardy J, Crews POrganic lettersA further study of the cytotoxic constituents of a milnamide-producing sponge. Org Lett. 2004 Mar 04; 6(5):779-82.Org Lett2004-03-04T00:00:002004A further study of the cytotoxic constituents of a milnamide-producing sponge.16962973Van Wagoner RM, Clardy JStructure (London, England : 1993)FeeM, an N-acyl amino acid synthase from an uncultured soil microbe: structure, mechanism, and acyl carrier protein binding. Structure. 2006 Sep; 14(9):1425-35.Structure2006-09-01T00:00:002006FeeM, an N-acyl amino acid synthase from an uncultured soil microbe: structure, mechanism, and acyl carrier protein binding.17850754Lautenschlager C, Leal WS, Clardy JStructure (London, England : 1993)Bombyx mori pheromone-binding protein binding nonpheromone ligands: implications for pheromone recognition. Structure. 2007 Sep; 15(9):1148-54.Structure2007-09-01T00:00:002007Bombyx mori pheromone-binding protein binding nonpheromone ligands: implications for pheromone recognition.Authorship 10268974Authorship 102641327Authorship 1026621629129376Brancucci NMB, Gerdt JP, Wang C, De Niz M, Philip N, Adapa SR, Zhang M, Hitz E, Niederwieser I, Boltryk SD, Laffitte MC, Clark MA, Grüring C, Ravel D, Blancke Soares A, Demas A, Bopp S, Rubio-Ruiz B, Conejo-Garcia A, Wirth DF, Gendaszewska-Darmach E, Duraisingh MT, Adams JH, Voss TS, Waters AP, Jiang RHY, Clardy J, Marti MCellLysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum. Cell. 2017 Dec 14; 171(7):1532-1544.e15.Cell2017-11-09T00:00:002017Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum.29134406Mevers E, Chouvenc T, Su NY, Clardy JJournal of chemical ecologyChemical Interaction among Termite-Associated Microbes. J Chem Ecol. 2017 Dec; 43(11-12):1078-1085.J Chem Ecol2017-11-13T00:00:002017Chemical Interaction among Termite-Associated Microbes.24272003Coll JC, Bowden BF, Heaton A, Scheuer PJ, Li MK, Clardy J, Schulte GK, Finer-Moore JJournal of chemical ecologyStructures and possible functions of epoxypukalide and pukalide : Diterpenes associated with eggs of sinularian soft corals (Cnidaria, Anthozoa, Octocorallia, Alcyonacea, Alcyoniidae). J Chem Ecol. 1989 Apr; 15(4):1177-91.J Chem Ecol1989-04-01T00:00:001989Structures and possible functions of epoxypukalide and pukalide : Diterpenes associated with eggs of sinularian soft corals (Cnidaria, Anthozoa, Octocorallia, Alcyonacea, Alcyoniidae).7996553Fuller RW, Cardellina JH, Jurek J, Scheuer PJ, Alvarado-Lindner B, McGuire M, Gray GN, Steiner JR, Clardy J, Menez EJournal of medicinal chemistryIsolation and structure/activity features of halomon-related antitumor monoterpenes from the red alga Portieria hornemannii. J Med Chem. 1994 Dec 09; 37(25):4407-11.J Med Chem1994-12-09T00:00:001994Isolation and structure/activity features of halomon-related antitumor monoterpenes from the red alga Portieria hornemannii.240 Longwood AveHarvard Medical SchoolBCMP, 643 C Bldg.240 Longwood AveBoston02115MA20133997Ndiaye D, Patel V, Demas A, LeRoux M, Ndir O, Mboup S, Clardy J, Lakshmanan V, Daily JP, Wirth DFThe American journal of tropical medicine and hygieneA non-radioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials--increased sensitivity of P. falciparum to chloroquine in Senegal. Am J Trop Med Hyg. 2010 Feb; 82(2):228-30.Am J Trop Med Hyg2010-02-01T00:00:002010A non-radioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials--increased sensitivity of P. falciparum to chloroquine in Senegal.20956299Mao Y, Xu X, Xu W, Ishida Y, Leal WS, Ames JB, Clardy JProceedings of the National Academy of Sciences of the United States of AmericaCrystal and solution structures of an odorant-binding protein from the southern house mosquito complexed with an oviposition pheromone. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):19102-7.Proc Natl Acad Sci U S A2010-10-18T00:00:002010Crystal and solution structures of an odorant-binding protein from the southern house mosquito complexed with an oviposition pheromone.22175477McMurry JE, Haley GJ, Matz JR, Clardy JC, Mitchell JJournal of the American Chemical SocietyPentacyclo[12.2.2.22,5.26,9.210,13]-1,5,9,13-tetracosatetraene and its reaction with silver trifluoromethanesulfonate. Synthesis of a square-planar d10 organometallic complex. J Am Chem Soc. 1986 Feb 01; 108(3):515-6.J Am Chem Soc1986-02-01T00:00:001986Pentacyclo[12.2.2.22,5.26,9.210,13]-1,5,9,13-tetracosatetraene and its reaction with silver trifluoromethanesulfonate. Synthesis of a square-planar d10 organometallic complex.17010675Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, Nieto M, Du J, Stegmaier K, Raj SM, Maloney KN, Clardy J, Hahn WC, Chiosis G, Golub TRCancer cellGene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell. 2006 Oct; 10(4):321-30.Cancer Cell2006-09-28T00:00:002006Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.22458669Cao S, McMillin DW, Tamayo G, Delmore J, Mitsiades CS, Clardy JJournal of natural productsInhibition of tumor cells interacting with stromal cells by xanthones isolated from a Costa Rican Penicillium sp. J Nat Prod. 2012 Apr 27; 75(4):793-7.J Nat Prod2012-03-29T00:00:002012Inhibition of tumor cells interacting with stromal cells by xanthones isolated from a Costa Rican Penicillium sp.22586124Derbyshire ER, Prudêncio M, Mota MM, Clardy JProceedings of the National Academy of Sciences of the United States of AmericaLiver-stage malaria parasites vulnerable to diverse chemical scaffolds. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8511-6.Proc Natl Acad Sci U S A2012-05-14T00:00:002012Liver-stage malaria parasites vulnerable to diverse chemical scaffolds.23394144Cryan LM, Bazinet L, Habeshian KA, Cao S, Clardy J, Christensen KA, Rogers MSJournal of medicinal chemistry1,2,3,4,6-Penta-O-galloyl-ß-D-glucopyranose inhibits angiogenesis via inhibition of capillary morphogenesis gene 2. J Med Chem. 2013 Mar 14; 56(5):1940-5.J Med Chem2013-02-22T00:00:0020131,2,3,4,6-Penta-O-galloyl-ß-D-glucopyranose inhibits angiogenesis via inhibition of capillary morphogenesis gene 2.23205187Findeis MA, Schroeder F, McKee TD, Yager D, Fraering PC, Creaser SP, Austin WF, Clardy J, Wang R, Selkoe D, Eckman CBACS chemical neuroscienceDiscovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa. ACS Chem Neurosci. 2012 Nov 21; 3(11):941-51.ACS Chem Neurosci2012-08-28T00:00:002012Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa.Authorship 10309564Authorship 1032515729225511Ramadhar TR, Zheng SL, Chen YS, Clardy JCrystEngCommThe Crystalline Sponge Method: A Solvent-Based Strategy to Facilitate Noncovalent Ordered Trapping of Solid and Liquid Organic Compounds. CrystEngComm. 2017 Aug 21; 19(31):4528-4534.CrystEngComm2017-07-14T00:00:002017The Crystalline Sponge Method: A Solvent-Based Strategy to Facilitate Noncovalent Ordered Trapping of Solid and Liquid Organic Compounds.29262868Fenn K, Strandwitz P, Stewart EJ, Dimise E, Rubin S, Gurubacharya S, Clardy J, Lewis KMicrobiomeQuinones are growth factors for the human gut microbiota. Microbiome. 2017 Dec 20; 5(1):161.Microbiome2017-12-20T00:00:002017Quinones are growth factors for the human gut microbiota.20338517D'Onofrio A, Crawford JM, Stewart EJ, Witt K, Gavrish E, Epstein S, Clardy J, Lewis KChemistry & biologySiderophores from neighboring organisms promote the growth of uncultured bacteria. Chem Biol. 2010 Mar 26; 17(3):254-64.Chem Biol2010-03-26T00:00:002010Siderophores from neighboring organisms promote the growth of uncultured bacteria.20431016Kolodkin-Gal I, Romero D, Cao S, Clardy J, Kolter R, Losick RScience (New York, N.Y.)D-amino acids trigger biofilm disassembly. Science. 2010 Apr 30; 328(5978):627-9.Science2010-04-30T00:00:002010D-amino acids trigger biofilm disassembly.20718474Urgaonkar S, Cortese JF, Barker RH, Cromwell M, Serrano AE, Wirth DF, Clardy J, Mazitschek ROrganic lettersA concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity. Org Lett. 2010 Sep 17; 12(18):3998-4001.Org Lett2010-09-17T00:00:002010A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity.932371Ireland C, Faulkner DJ, Finer J, Clardy JJournal of the American Chemical SocietyLetter: A novel diterpene from Dollabella californica. J Am Chem Soc. 1976 Jul 21; 98(15):4664-5.J Am Chem Soc1976-07-21T00:00:001976Letter: A novel diterpene from Dollabella californica.7931366Pcolinski MJ, Doskotch RW, Lee AY, Clardy JJournal of natural productsChlorosilphanol A and silphanepoxol, labdane diterpenes from Silphium perfoliatum. J Nat Prod. 1994 Jun; 57(6):776-83.J Nat Prod1994-06-01T00:00:001994Chlorosilphanol A and silphanepoxol, labdane diterpenes from Silphium perfoliatum.1133368Clardy J, Springer JP, Buchi G, Matsuo K, Wightman RJournal of the American Chemical SocietyLetter: Tryptoquivaline and tryptoquivalone, two tremorgenic metabolites of aspergillus clavatus. J Am Chem Soc. 1975 Feb 05; 97(3):663-5.J Am Chem Soc1975-02-05T00:00:001975Letter: Tryptoquivaline and tryptoquivalone, two tremorgenic metabolites of aspergillus clavatus.8732754Ganesh V, Lee AY, Clardy J, Tulinsky AProtein science : a publication of the Protein SocietyComparison of the structures of the cyclotheonamide A complexes of human alpha-thrombin and bovine beta-trypsin. Protein Sci. 1996 May; 5(5):825-35.Protein Sci1996-05-01T00:00:001996Comparison of the structures of the cyclotheonamide A complexes of human alpha-thrombin and bovine beta-trypsin.20022247Crawford JM, Kontnik R, Clardy JCurrent biology : CBRegulating alternative lifestyles in entomopathogenic bacteria. Curr Biol. 2010 Jan 12; 20(1):69-74.Curr Biol2010-01-12T00:00:002010Regulating alternative lifestyles in entomopathogenic bacteria.22767929Somvanshi VS, Sloup RE, Crawford JM, Martin AR, Heidt AJ, Kim KS, Clardy J, Ciche TAScience (New York, N.Y.)A single promoter inversion switches Photorhabdus between pathogenic and mutualistic states. Science. 2012 Jul 06; 337(6090):88-93.Science2012-07-06T00:00:002012A single promoter inversion switches Photorhabdus between pathogenic and mutualistic states.Authorship 10387251129348592Paludo CR, Menezes C, Silva-Junior EA, Vollet-Neto A, Andrade-Dominguez A, Pishchany G, Khadempour L, do Nascimento FS, Currie CR, Kolter R, Clardy J, Pupo MTScientific reportsStingless Bee Larvae Require Fungal Steroid to Pupate. Sci Rep. 2018 01 18; 8(1):1122.Sci Rep2018-01-18T00:00:002018Stingless Bee Larvae Require Fungal Steroid to Pupate.23025282Carr G, Derbyshire ER, Caldera E, Currie CR, Clardy JJournal of natural productsAntibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp. J Nat Prod. 2012 Oct 26; 75(10):1806-9.J Nat Prod2012-10-01T00:00:002012Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp.23406351Böttcher T, Kolodkin-Gal I, Kolter R, Losick R, Clardy JJournal of the American Chemical SocietySynthesis and activity of biomimetic biofilm disruptors. J Am Chem Soc. 2013 Feb 27; 135(8):2927-30.J Am Chem Soc2013-02-18T00:00:002013Synthesis and activity of biomimetic biofilm disruptors.17718493Schmitz K, Haggarty SJ, McPherson OM, Clardy J, Koehler ANJournal of the American Chemical SocietyDetecting binding interactions using microarrays of natural product extracts. J Am Chem Soc. 2007 Sep 19; 129(37):11346-7.J Am Chem Soc2007-08-24T00:00:002007Detecting binding interactions using microarrays of natural product extracts.18461159Stotz SC, Vriens J, Martyn D, Clardy J, Clapham DEPloS oneCitral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One. 2008 May 07; 3(5):e2082.PLoS One2008-05-07T00:00:002008Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons.Authorship 10403791029361220Puri AW, Mevers E, Ramadhar TR, Petras D, Liu D, Piel J, Dorrestein PC, Greenberg EP, Lidstrom ME, Clardy JJournal of the American Chemical SocietyTundrenone: An Atypical Secondary Metabolite from Bacteria with Highly Restricted Primary Metabolism. J Am Chem Soc. 2018 02 14; 140(6):2002-2006.J Am Chem Soc2018-01-30T00:00:002018Tundrenone: An Atypical Secondary Metabolite from Bacteria with Highly Restricted Primary Metabolism.853193Sun HH, Waraszkiewicz SM, Erickson KL, Finer KL, Clardy JJournal of the American Chemical SocietyDictyoxepin and dictyolene, two new diterpenes from the marine alga Dictyota acutiloba (Phaeophyta) J Am Chem Soc. 1977 May 11; 99(10):3516-7.J Am Chem Soc1977-05-11T00:00:001977Dictyoxepin and dictyolene, two new diterpenes from the marine alga Dictyota acutiloba (Phaeophyta)1133356Anderson GD, Powers TJ, Djerassi C, Fayos J, Clardy JJournal of the American Chemical SocietyA stereoselective synthesis of two stereoisomers of demethylgorgosterol. J Am Chem Soc. 1975 Jan 22; 97(2):388-94.J Am Chem Soc1975-01-22T00:00:001975A stereoselective synthesis of two stereoisomers of demethylgorgosterol.8621357Kirst HA, Mynderse JS, Martin JW, Baker PJ, Paschal JW, Rios Steiner JL, Lobkovsky E, Clardy JThe Journal of antibioticsStructure of the spiroketal-macrolide ossamycin. J Antibiot (Tokyo). 1996 Feb; 49(2):162-7.J Antibiot (Tokyo)1996-02-01T00:00:001996Structure of the spiroketal-macrolide ossamycin.8702302Milner JL, Silo-Suh L, Lee JC, He H, Clardy J, Handelsman JApplied and environmental microbiologyProduction of kanosamine by Bacillus cereus UW85. Appl Environ Microbiol. 1996 Aug; 62(8):3061-5.Appl Environ Microbiol1996-08-01T00:00:001996Production of kanosamine by Bacillus cereus UW85.18842591Patel V, Booker M, Kramer M, Ross L, Celatka CA, Kennedy LM, Dvorin JD, Duraisingh MT, Sliz P, Wirth DF, Clardy JThe Journal of biological chemistryIdentification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem. 2008 Dec 12; 283(50):35078-85.J Biol Chem2008-10-08T00:00:002008Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.19097788Dong CK, Patel V, Yang JC, Dvorin JD, Duraisingh MT, Clardy J, Wirth DFBioorganic & medicinal chemistry lettersType II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorg Med Chem Lett. 2009 Feb 01; 19(3):972-5.Bioorg Med Chem Lett2008-11-24T00:00:002008Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors.19349961Macosko EZ, Pokala N, Feinberg EH, Chalasani SH, Butcher RA, Clardy J, Bargmann CINatureA hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans. Nature. 2009 Apr 30; 458(7242):1171-5.Nature2009-04-06T00:00:002009A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans.22716461Chen Y, Cao S, Chai Y, Clardy J, Kolter R, Guo JH, Losick RMolecular microbiologyA Bacillus subtilis sensor kinase involved in triggering biofilm formation on the roots of tomato plants. Mol Microbiol. 2012 Aug; 85(3):418-30.Mol Microbiol2012-06-20T00:00:002012A Bacillus subtilis sensor kinase involved in triggering biofilm formation on the roots of tomato plants.Authorship 10331612746817Dahl JE, Moldowan JM, Peakman TM, Clardy JC, Lobkovsky E, Olmstead MM, May PW, Davis TJ, Steeds JW, Peters KE, Pepper A, Ekuan A, Carlson RMAngewandte Chemie (International ed. in English)Isolation and structural proof of the large diamond molecule, cyclohexamantane (C26H30). Angew Chem Int Ed Engl. 2003 May 09; 42(18):2040-4.Angew Chem Int Ed Engl2003-05-09T00:00:002003Isolation and structural proof of the large diamond molecule, cyclohexamantane (C26H30).12833353Jin M, Liu L, Wright SA, Beer SV, Clardy JAngewandte Chemie (International ed. in English)Structural and functional analysis of pantocin A: an antibiotic from Pantoea agglomerans discovered by heterologous expression of cloned genes. Angew Chem Int Ed Engl. 2003 Jun 30; 42(25):2898-901.Angew Chem Int Ed Engl2003-06-30T00:00:002003Structural and functional analysis of pantocin A: an antibiotic from Pantoea agglomerans discovered by heterologous expression of cloned genes.10089371Kongsaeree P, Liang J, Jensen RA, Clardy JActa crystallographica. Section D, Biological crystallographyCrystallization and preliminary X-ray crystallographic analysis of the Pseudomonas aeruginosa cyclohexadienyl dehydratase. Acta Crystallogr D Biol Crystallogr. 1999 Feb; 55(Pt 2):539-41.Acta Crystallogr D Biol Crystallogr1999-02-01T00:00:001999Crystallization and preliminary X-ray crystallographic analysis of the Pseudomonas aeruginosa cyclohexadienyl dehydratase.16111659Lautenschlager C, Leal WS, Clardy JBiochemical and biophysical research communicationsCoil-to-helix transition and ligand release of Bombyx mori pheromone-binding protein. Biochem Biophys Res Commun. 2005 Oct 07; 335(4):1044-50.Biochem Biophys Res Commun2005-10-07T00:00:002005Coil-to-helix transition and ligand release of Bombyx mori pheromone-binding protein.1501227Fuller RW, Cardellina JH, Kato Y, Brinen LS, Clardy J, Snader KM, Boyd MRJournal of medicinal chemistryA pentahalogenated monoterpene from the red alga Portieria hornemannii produces a novel cytotoxicity profile against a diverse panel of human tumor cell lines. J Med Chem. 1992 Aug 07; 35(16):3007-11.J Med Chem1992-08-07T00:00:001992A pentahalogenated monoterpene from the red alga Portieria hornemannii produces a novel cytotoxicity profile against a diverse panel of human tumor cell lines.