Iliopoulos, Othon
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full name: Othon Iliopoulos, M.D.
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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.
PubMed Identifier: 10213691
author list: Kamura T, Koepp DM, Conrad MN, Skowyra D, Moreland RJ, Iliopoulos O, Lane WS, Kaelin WG, Elledge SJ, Conaway RC, Harper JW, Conaway JW
published in: Science (New York, N.Y.)
information resource reference: Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Science. 1999 Apr 23; 284(5414):657-61.
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Molecular markers for early detection of renal carcinoma: investigative approach.
PubMed Identifier: 15448020
author list: Skates S, Iliopoulos O
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Molecular markers for early detection of renal carcinoma: investigative approach. Clin Cancer Res. 2004 Sep 15; 10(18 Pt 2):6296S-301S.
journal title abbreviation: Clin Cancer Res
publication date: 2004-09-15T00:00:00
year: 2004
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Tumour suppression by the human von Hippel-Lindau gene product.
PubMed Identifier: 7585187
author list: Iliopoulos O, Kibel A, Gray S, Kaelin WG
published in: Nature medicine
information resource reference: Tumour suppression by the human von Hippel-Lindau gene product. Nat Med. 1995 Aug; 1(8):822-6.
journal title abbreviation: Nat Med
publication date: 1995-08-01T00:00:00
year: 1995
type: Academic Article
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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia.
PubMed Identifier: 22101433
author list: Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G
published in: Nature
information resource reference: Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature. 2011 Nov 20; 481(7381):380-4.
journal title abbreviation: Nature
publication date: 2011-11-20T00:00:00
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Epithelial cell guidance by self-generated EGF gradients.
PubMed Identifier: 22314635
author list: Scherber C, Aranyosi AJ, Kulemann B, Thayer SP, Toner M, Iliopoulos O, Irimia D
published in: Integrative biology : quantitative biosciences from nano to macro
information resource reference: Epithelial cell guidance by self-generated EGF gradients. Integr Biol (Camb). 2012 Mar; 4(3):259-69.
journal title abbreviation: Integr Biol (Camb)
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Multidimensional liquid chromatography platform for profiling alterations of clusterin N-glycosylation in the plasma of patients with renal cell carcinoma.
PubMed Identifier: 22885037
author list: Tousi F, Bones J, Iliopoulos O, Hancock WS, Hincapie M
published in: Journal of chromatography. A
information resource reference: Multidimensional liquid chromatography platform for profiling alterations of clusterin N-glycosylation in the plasma of patients with renal cell carcinoma. J Chromatogr A. 2012 Sep 21; 1256:121-8.
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linked information resource: Case 36-2018: A 29-Year-Old Man with an Incidentally Discovered Renal Mass.

Case 36-2018: A 29-Year-Old Man with an Incidentally Discovered Renal Mass.
PubMed Identifier: 30462933
author list: Dahl DM, Simeone JF, Iliopoulos O, Saylor PJ, Wu CL
published in: The New England journal of medicine
information resource reference: Case 36-2018: A 29-Year-Old Man with an Incidentally Discovered Renal Mass. N Engl J Med. 2018 11 22; 379(21):2064-2072.
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Genetic and clinical aspects of familial renal neoplasms.
PubMed Identifier: 10768593
author list: Iliopoulos O, Eng C
published in: Seminars in oncology
information resource reference: Genetic and clinical aspects of familial renal neoplasms. Semin Oncol. 2000 Apr; 27(2):138-49.
journal title abbreviation: Semin Oncol
publication date: 2000-04-01T00:00:00
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Molecular genetics of kidney cancer.
PubMed Identifier: 14650823
author list: Zimmer M, Iliopoulos O
published in: Cancer treatment and research
information resource reference: Molecular genetics of kidney cancer. Cancer Treat Res. 2003; 116:3-27.
journal title abbreviation: Cancer Treat Res
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Innovations and challenges in renal cancer: consensus statement from the first international conference.
PubMed Identifier: 15448017
author list: Atkins MB, Avigan DE, Bukowski RM, Childs RW, Dutcher JP, Eisen TG, Figlin RA, Finke JH, Flanigan RC, George DJ, Goldberg SN, Gordon MS, Iliopoulos O, Kaelin WG, Linehan WM, Lipton A, Motzer RJ, Novick AC, Stadler WM, Teh BT, Yang JC, King L
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Innovations and challenges in renal cancer: consensus statement from the first international conference. Clin Cancer Res. 2004 Sep 15; 10(18 Pt 2):6277S-81S.
journal title abbreviation: Clin Cancer Res
publication date: 2004-09-15T00:00:00
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In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation.
PubMed Identifier: 23473032
author list: Gameiro PA, Yang J, Metelo AM, Pérez-Carro R, Baker R, Wang Z, Arreola A, Rathmell WK, Olumi A, López-Larrubia P, Stephanopoulos G, Iliopoulos O
published in: Cell metabolism
information resource reference: In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation. Cell Metab. 2013 Mar 05; 17(3):372-85.
journal title abbreviation: Cell Metab
publication date: 2013-03-05T00:00:00
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Observations on nasal late phase reactions.
PubMed Identifier: 3330982
author list: Naclerio RM, Kagey-Sobotka A, Lichtenstein LM, Togias AG, Iliopoulos O, Pipkorn U, Bascom R, Norman PS, Proud D
published in: Immunological investigations
information resource reference: Observations on nasal late phase reactions. Immunol Invest. 1987-1988 Dec; 16(8):649-85.
journal title abbreviation: Immunol Invest
publication date: 1987-01-01T00:00:00
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Von Hippel-Lindau Tumor Suppressor Protein
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Hemangioblastoma
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Carcinoma, Renal Cell
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MGH Cancer Center Research
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Kidney Neoplasms
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von Hippel-Lindau Disease
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Signoretti, Sabina
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Raje, Noopur
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Motamedi, Mo
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Wirth, Lori
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Choueiri, Toni
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Fisher, David
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Chen, Yi-Bin
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Kaelin, William
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Flaherty, Keith
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Stone, James
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Soumerai, Tara
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McDermott, David
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Blute, Michael
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Authorship 114711
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linked author: Iliopoulos, Othon
linked information resource: Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C.

Professor of Medicine
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Sidney Farber Professor of Medicine
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linked information resource: Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells.

Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction.
PubMed Identifier: 32651261
author list: Madala HR, Helenius IT, Zhou W, Mills E, Zhang Y, Liu Y, Metelo AM, Kelley ML, Punganuru S, Kim KB, Olenchock B, Rhee E, Intlekofer AM, Iliopoulos O, Chouchani E, Yeh JJ
published in: Cancer research
information resource reference: Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction. Cancer Res. 2020 09 01; 80(17):3492-3506.
journal title abbreviation: Cancer Res
publication date: 2020-07-10T00:00:00
year: 2020
type: Academic Article
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linked information resource: Molecular markers for early detection of renal carcinoma: investigative approach.

Authorship 1282835
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linked information resource: Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction.

Authorship 1287938
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linked author: Iliopoulos, Othon
linked information resource: Evaluation, diagnosis and surveillance of renal masses in the setting of VHL disease.

Evaluation, diagnosis and surveillance of renal masses in the setting of VHL disease.
PubMed Identifier: 32936333
author list: Chahoud J, McGettigan M, Parikh N, Boris RS, Iliopoulos O, Rathmell WK, Daniels AB, Jonasch E, Spiess PE
published in: World journal of urology
information resource reference: Evaluation, diagnosis and surveillance of renal masses in the setting of VHL disease. World J Urol. 2021 Jul; 39(7):2409-2415.
journal title abbreviation: World J Urol
publication date: 2020-09-16T00:00:00
year: 2020
type: Academic Article
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Authorship 1344111
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linked author: Iliopoulos, Othon
linked information resource: Differential substrate use in EGF- and oncogenic KRAS-stimulated human mammary epithelial cells.

Differential substrate use in EGF- and oncogenic KRAS-stimulated human mammary epithelial cells.
PubMed Identifier: 33811729
author list: Keibler MA, Dong W, Korthauer KD, Hosios AM, Moon SJ, Sullivan LB, Liu N, Abbott KL, Arevalo OD, Ho K, Lee J, Phanse AS, Kelleher JK, Iliopoulos O, Coloff JL, Vander Heiden MG, Stephanopoulos G
published in: The FEBS journal
information resource reference: Differential substrate use in EGF- and oncogenic KRAS-stimulated human mammary epithelial cells. FEBS J. 2021 10; 288(19):5629-5649.
journal title abbreviation: FEBS J
publication date: 2021-05-13T00:00:00
year: 2021
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Authorship 146690
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linked information resource: pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation.

NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism.
PubMed Identifier: 34233163
author list: Allouche J, Rachmin I, Adhikari K, Pardo LM, Lee JH, McConnell AM, Kato S, Fan S, Kawakami A, Suita Y, Wakamatsu K, Igras V, Zhang J, Navarro PP, Lugo CM, Noonan HR, Christie KA, Itin K, Mujahid N, Lo JA, Won CH, Evans CL, Weng QY, Wang H, Osseiran S, Lovas A, Németh I, Cozzio A, Navarini AA, Hsiao JJ, Nguyen N, Kemény LV, Iliopoulos O, Berking C, Ruzicka T, Gonzalez-José R, Bortolini MC, Canizales-Quinteros S, Acuna-Alonso V, Gallo C, Poletti G, Bedoya G, Rothhammer F, Ito S, Schiaffino MV, Chao LH, Kleinstiver BP, Tishkoff S, Zon LI, Nijsten T, Ruiz-Linares A, Fisher DE, Roider E
published in: Cell
information resource reference: NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. Cell. 2021 08 05; 184(16):4268-4283.e20.
journal title abbreviation: Cell
publication date: 2021-07-06T00:00:00
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Authorship 1373473
type: Authorship
author rank in publication: 33
linked author: Iliopoulos, Othon
linked information resource: NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism.

Authorship 1382703
type: Authorship
author rank in publication: 30
linked author: Iliopoulos, Othon
linked information resource: Genetic risk assessment for hereditary renal cell carcinoma: Clinical consensus statement.

Genetic risk assessment for hereditary renal cell carcinoma: Clinical consensus statement.
PubMed Identifier: 34343338
author list: Bratslavsky G, Mendhiratta N, Daneshvar M, Brugarolas J, Ball MW, Metwalli A, Nathanson KL, Pierorazio PM, Boris RS, Singer EA, Carlo MI, Daly MB, Henske EP, Hyatt C, Middleton L, Morris G, Jeong A, Narayan V, Rathmell WK, Vaishampayan U, Lee BH, Battle D, Hall MJ, Hafez K, Jewett MAS, Karamboulas C, Pal SK, Hakimi AA, Kutikov A, Iliopoulos O, Linehan WM, Jonasch E, Srinivasan R, Shuch B
published in: Cancer
information resource reference: Genetic risk assessment for hereditary renal cell carcinoma: Clinical consensus statement. Cancer. 2021 Nov 01; 127(21):3957-3966.
journal title abbreviation: Cancer
publication date: 2021-08-03T00:00:00
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The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability.
PubMed Identifier: 34805795
author list: Calvo IA, Sharma S, Paulo JA, Gulka AOD, Boeszoermenyi A, Zhang J, Lombana JM, Palmieri CM, Laviolette LA, Arthanari H, Iliopoulos O, Gygi SP, Motamedi M
published in: iScience
information resource reference: The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability. iScience. 2021 Nov 19; 24(11):103338.
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publication date: 2021-10-23T00:00:00
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Authorship 1412193
type: Authorship
author rank in publication: 11
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linked information resource: The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability.

Authorship 1414104
type: Authorship
author rank in publication: 3
linked author: Iliopoulos, Othon
linked information resource: Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease.

Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease.
PubMed Identifier: 34818478
author list: Jonasch E, Donskov F, Iliopoulos O, Rathmell WK, Narayan VK, Maughan BL, Oudard S, Else T, Maranchie JK, Welsh SJ, Thamake S, Park EK, Perini RF, Linehan WM, Srinivasan R
published in: The New England journal of medicine
information resource reference: Belzutifan for Renal Cell Carcinoma in von Hippel-Lindau Disease. N Engl J Med. 2021 11 25; 385(22):2036-2046.
journal title abbreviation: N Engl J Med
publication date: 2021-11-25T00:00:00
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Authorship 1427867
type: Authorship
author rank in publication: 9
linked author: Iliopoulos, Othon
linked information resource: Seventh BHD international symposium: recent scientific and clinical advancement.

Seventh BHD international symposium: recent scientific and clinical advancement.
PubMed Identifier: 35070081
author list: Woodford MR, Andreou A, Baba M, van de Beek I, Di Malta C, Glykofridis I, Grimes H, Henske EP, Iliopoulos O, Kurihara M, Lazor R, Linehan WM, Matsumoto K, Marciniak SJ, Namba Y, Pause A, Rajan N, Ray A, Schmidt LS, Shi W, Steinlein OK, Thierauf J, Zoncu R, Webb A, Mollapour M
published in: Oncotarget
information resource reference: Seventh BHD international symposium: recent scientific and clinical advancement. Oncotarget. 2022; 13:173-181.
journal title abbreviation: Oncotarget
publication date: 2022-01-20T00:00:00
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Authorship 228845
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linked author: Iliopoulos, Othon
linked information resource: Studies on the allergic and nonallergic nasal inflammation.

Authorship 236729
type: Authorship
author rank in publication: 8
linked author: Iliopoulos, Othon
linked information resource: The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2.

Authorship 1449277
type: Authorship
author rank in publication: 3
linked author: Iliopoulos, Othon
linked information resource: Telaglenastat Plus Cabozantinib or Everolimus for Advanced or Metastatic Renal Cell Carcinoma: An Open-Label Phase I Trial.

Telaglenastat Plus Cabozantinib or Everolimus for Advanced or Metastatic Renal Cell Carcinoma: An Open-Label Phase I Trial.
PubMed Identifier: 35140121
author list: Meric-Bernstam F, Tannir NM, Iliopoulos O, Lee RJ, Telli ML, Fan AC, DeMichele A, Haas NB, Patel MR, Harding JJ, Voss MH, Owonikoko TK, Carthon B, Srinivasan R, Bendell JC, Jenkins Y, Whiting SH, Orford K, Bennett MK, Bauer TM
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Telaglenastat Plus Cabozantinib or Everolimus for Advanced or Metastatic Renal Cell Carcinoma: An Open-Label Phase I Trial. Clin Cancer Res. 2022 04 14; 28(8):1540-1548.
journal title abbreviation: Clin Cancer Res
publication date: 2022-04-14T00:00:00
year: 2022
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type: Document
type: Information Resource

Authorship 1493214
type: Authorship
author rank in publication: 8
linked author: Iliopoulos, Othon
linked information resource: Understanding the Impact of Belzutifan on Treatment Strategies for Patients with VHL.

Understanding the Impact of Belzutifan on Treatment Strategies for Patients with VHL.
PubMed Identifier: 36310638
author list: Arevalo A, Patel N, Muraki P, Ohtake S, Bratslavsky G, Clark C, Mann J, Iliopoulos O, Jonasch E, Srinivasan R, Shuch B
published in: Journal of kidney cancer and VHL
information resource reference: Understanding the Impact of Belzutifan on Treatment Strategies for Patients with VHL. J Kidney Cancer VHL. 2022; 9(3):41-46.
journal title abbreviation: J Kidney Cancer VHL
publication date: 2022-09-28T00:00:00
year: 2022
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type: Document
type: Information Resource

Authorship 1534373
type: Authorship
author rank in publication: 1
linked author: Iliopoulos, Othon
linked information resource: Diseases of Hereditary Renal Cell Cancers.

Diseases of Hereditary Renal Cell Cancers.
PubMed Identifier: 36948667
author list: Iliopoulos O
published in: The Urologic clinics of North America
information resource reference: Diseases of Hereditary Renal Cell Cancers. Urol Clin North Am. 2023 May; 50(2):205-215.
journal title abbreviation: Urol Clin North Am
publication date: 2023-05-01T00:00:00
year: 2023
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Trinh, Michael
eCommons Login: mit821
first name: Michael
last name: Trinh
full name: Michael Nguyen Trinh, M.D.,Ph.D.
has faculty rank: Fellow or Post Doc
photo: https://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 213807
person in primary position: Clinical Fellow in Medicine
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preferred title: Clinical Fellow in Medicine

Professor of Medicine
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position in division: Hematology/Oncology
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HR job title: Professor of Medicine
position in organization: Massachusetts General Hospital

Authorship 254582
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author rank in publication: 1
linked author: Iliopoulos, Othon
linked information resource: Case records of the Massachusetts General Hospital. Case 23-2006. A 36-year-old man with numbness in the left [corrected] hand and hypertension.

Authorship 1611267
type: Authorship
author rank in publication: 19
linked author: Iliopoulos, Othon
linked information resource: MITF regulates IDH1 and NNT and drives a transcriptional program protecting cutaneous melanoma from reactive oxygen species.

MITF regulates IDH1 and NNT and drives a transcriptional program protecting cutaneous melanoma from reactive oxygen species.
PubMed Identifier: 38014031
author list: Roider E, Lakatos AIT, McConnell AM, Wang P, Mueller A, Kawakami A, Tsoi J, Szabolcs BL, Ascsillán AA, Suita Y, Igras V, Lo JA, Hsiao JJ, Lapides R, Pál DMP, Lengyel AS, Navarini A, Okazaki A, Iliopoulos O, Németh I, Graeber TG, Zon L, Giese RW, Kemeny LV, Fisher DE
published in: bioRxiv : the preprint server for biology
information resource reference: MITF regulates IDH1 and NNT and drives a transcriptional program protecting cutaneous melanoma from reactive oxygen species. bioRxiv. 2023 Nov 14.
journal title abbreviation: bioRxiv
publication date: 2023-11-14T00:00:00
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Authorship 56030
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author rank in publication: 1
linked author: Iliopoulos, Othon
linked information resource: Effects of immunotherapy on the early, late, and rechallenge nasal reaction to provocation with allergen: changes in inflammatory mediators and cells.

Authorship 1646658
type: Authorship
author rank in publication: 3
linked author: Iliopoulos, Othon
linked information resource: Belzutifan for von Hippel-Lindau Disease: Pancreatic Lesion Population of the Phase 2 LITESPARK-004 Study.

Belzutifan for von Hippel-Lindau Disease: Pancreatic Lesion Population of the Phase 2 LITESPARK-004 Study.
PubMed Identifier: 38393723
author list: Else T, Jonasch E, Iliopoulos O, Beckermann KE, Narayan V, Maughan BL, Oudard S, Maranchie JK, Iversen AB, Goldberg CM, Fu W, Perini RF, Liu Y, Linehan WM, Srinivasan R
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Belzutifan for von Hippel-Lindau Disease: Pancreatic Lesion Population of the Phase 2 LITESPARK-004 Study. Clin Cancer Res. 2024 May 01; 30(9):1750-1757.
journal title abbreviation: Clin Cancer Res
publication date: 2024-05-01T00:00:00
year: 2024
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type: Document
type: Information Resource

Authorship 336587
type: Authorship
author rank in publication: 8
linked author: Iliopoulos, Othon
linked information resource: Loss of RBF1 changes glutamine catabolism.

Professor of Pathology
is primary position: true
position in department: Pathology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
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HR job title: Professor of Pathology
position in organization: Brigham and Women's Hospital

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Hematology/Oncology
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Massachusetts General Hospital

Instructor in Medicine
is primary position: true
position in department: Medicine
position in division: Hematology/Oncology
sort order: 1
type: Position
HR job title: Instructor in Medicine
position in organization: Massachusetts General Hospital

Jerome and Nancy Kohlberg Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Jerome and Nancy Kohlberg Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Associate Professor of Pathology
is primary position: true
position in department: Pathology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Associate Professor of Pathology
position in organization: Massachusetts General Hospital

Walter S. Kerr, Jr. Distinguished Professor of Surgery
is primary position: true
position in department: Surgery
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Walter S. Kerr, Jr. Distinguished Professor of Surgery
position in organization: Massachusetts General Hospital

Authorship 470985
type: Authorship
author rank in publication: 2
linked author: Iliopoulos, Othon
linked information resource: Case records of the Massachusetts General Hospital. Case 17-2008. A 63-year-old man with metastatic renal-cell carcinoma.

Authorship 252517
type: Authorship
author rank in publication: 1
linked author: Iliopoulos, Othon
linked information resource: von Hippel-Lindau disease: genetic and clinical observations.

Authorship 328745
type: Authorship
author rank in publication: 3
linked author: Iliopoulos, Othon
linked information resource: Acute renal failure following binge drinking and nonsteroidal antiinflammatory drugs.

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Hematology/Oncology
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Massachusetts General Hospital

Authorship 648763
type: Authorship
author rank in publication: 9
linked author: Iliopoulos, Othon
linked information resource: Human folliculin delays cell cycle progression through late S and G2/M-phases: effect of phosphorylation and tumor associated mutations.

Authorship 659098
type: Authorship
author rank in publication: 4
linked author: Iliopoulos, Othon
linked information resource: Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle.

Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle.
PubMed Identifier: 23504317
author list: Gameiro PA, Laviolette LA, Kelleher JK, Iliopoulos O, Stephanopoulos G
published in: The Journal of biological chemistry
information resource reference: Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle. J Biol Chem. 2013 May 03; 288(18):12967-77.
journal title abbreviation: J Biol Chem
publication date: 2013-03-15T00:00:00
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type: Academic Article
type: Article
type: Document
type: Information Resource

Human folliculin delays cell cycle progression through late S and G2/M-phases: effect of phosphorylation and tumor associated mutations.
PubMed Identifier: 23874397
author list: Laviolette LA, Wilson J, Koller J, Neil C, Hulick P, Rejtar T, Karger B, Teh BT, Iliopoulos O
published in: PloS one
information resource reference: Human folliculin delays cell cycle progression through late S and G2/M-phases: effect of phosphorylation and tumor associated mutations. PLoS One. 2013; 8(7):e66775.
journal title abbreviation: PLoS One
publication date: 2013-07-11T00:00:00
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type: Document
type: Information Resource

Authorship 1695809
type: Authorship
author rank in publication: 19
linked author: Iliopoulos, Othon
linked information resource: MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species.

Authorship 1701827
type: Authorship
author rank in publication: 1
linked author: Iliopoulos, Othon
linked information resource: Belzutifan for patients with von Hippel-Lindau disease-associated CNS haemangioblastomas (LITESPARK-004): a multicentre, single-arm, phase 2 study.

Belzutifan for patients with von Hippel-Lindau disease-associated CNS haemangioblastomas (LITESPARK-004): a multicentre, single-arm, phase 2 study.
PubMed Identifier: 39284337
author list: Iliopoulos O, Iversen AB, Narayan V, Maughan BL, Beckermann KE, Oudard S, Else T, Maranchie JK, Goldberg CM, Fu W, Perini RF, Liu Y, Linehan WM, Srinivasan R, Jonasch E
published in: The Lancet. Oncology
information resource reference: Belzutifan for patients with von Hippel-Lindau disease-associated CNS haemangioblastomas (LITESPARK-004): a multicentre, single-arm, phase 2 study. Lancet Oncol. 2024 10; 25(10):1325-1336.
journal title abbreviation: Lancet Oncol
publication date: 2024-09-13T00:00:00
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type: Academic Article
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type: Information Resource

MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species.
PubMed Identifier: 39277608
author list: Roider E, Lakatos AIT, McConnell AM, Wang P, Mueller A, Kawakami A, Tsoi J, Szabolcs BL, Ascsillán AA, Suita Y, Igras V, Lo JA, Hsiao JJ, Lapides R, Pál DMP, Lengyel AS, Navarini A, Okazaki A, Iliopoulos O, Németh I, Graeber TG, Zon L, Giese RW, Kemeny LV, Fisher DE
published in: Scientific reports
information resource reference: MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species. Sci Rep. 2024 09 14; 14(1):21527.
journal title abbreviation: Sci Rep
publication date: 2024-09-14T00:00:00
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Authorship 686254
type: Authorship
author rank in publication: 2
linked author: Iliopoulos, Othon
linked information resource: Immunoaffinity enrichment and liquid chromatography-selected reaction monitoring mass spectrometry for quantitation of carbonic anhydrase 12 in cultured renal carcinoma cells.

Immunoaffinity enrichment and liquid chromatography-selected reaction monitoring mass spectrometry for quantitation of carbonic anhydrase 12 in cultured renal carcinoma cells.
PubMed Identifier: 20936840
author list: Rafalko A, Iliopoulos O, Fusaro VA, Hancock W, Hincapie M
published in: Analytical chemistry
information resource reference: Immunoaffinity enrichment and liquid chromatography-selected reaction monitoring mass spectrometry for quantitation of carbonic anhydrase 12 in cultured renal carcinoma cells. Anal Chem. 2010 Nov 01; 82(21):8998-9005.
journal title abbreviation: Anal Chem
publication date: 2010-10-11T00:00:00
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Authorship 1740732
type: Authorship
author rank in publication: 2
linked author: Iliopoulos, Othon
linked information resource: Belzutifan for von Hippel-Lindau disease-associated renal cell carcinoma and other neoplasms (LITESPARK-004): 50 months follow-up from a single-arm, phase 2 study.

Authorship 1748885
type: Authorship
author rank in publication: 4
linked author: Iliopoulos, Othon
linked information resource: "Incidentally" discovered Von Hippel Lindau disease: an emerging clinical phenotype.

"Incidentally" discovered Von Hippel Lindau disease: an emerging clinical phenotype.
PubMed Identifier: 40063608
author list: Trinh MN, Bear L, Nahed BV, Iliopoulos O
published in: The oncologist
information resource reference: "Incidentally" discovered Von Hippel Lindau disease: an emerging clinical phenotype. Oncologist. 2025 Mar 10; 30(3).
journal title abbreviation: Oncologist
publication date: 2025-03-10T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Belzutifan for von Hippel-Lindau disease-associated renal cell carcinoma and other neoplasms (LITESPARK-004): 50 months follow-up from a single-arm, phase 2 study.
PubMed Identifier: 40228516
author list: Srinivasan R, Iliopoulos O, Beckermann KE, Narayan V, Maughan BL, Oudard S, Else T, Maranchie JK, Iversen AB, Cornell J, Perini RF, Liu Y, Linehan WM, Jonasch E
published in: The Lancet. Oncology
information resource reference: Belzutifan for von Hippel-Lindau disease-associated renal cell carcinoma and other neoplasms (LITESPARK-004): 50 months follow-up from a single-arm, phase 2 study. Lancet Oncol. 2025 May; 26(5):571-582.
journal title abbreviation: Lancet Oncol
publication date: 2025-04-12T00:00:00
year: 2025
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Authorship 230958
type: Authorship
author rank in publication: 5
linked author: Iliopoulos, Othon
linked information resource: Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer.

Clinical Fellow in Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Clinical Fellow in Medicine
position in organization: Brigham and Women's Hospital

Authorship 259879
type: Authorship
author rank in publication: 6
linked author: Iliopoulos, Othon
linked information resource: Epithelial cell guidance by self-generated EGF gradients.

Victor J. Aresty Professor of Medicine
is primary position: true
position in department: Medicine
position in division: DF Melanoma
sort order: 1
type: Position
HR job title: Victor J. Aresty Professor of Medicine
position in organization: Beth Israel Deaconess Medical Center

DF Melanoma
type: Division
type: Organization

Authorship 1829057
type: Authorship
author rank in publication: 15
linked author: Iliopoulos, Othon
linked information resource: Belzutifan for Advanced Pheochromocytoma or Paraganglioma.

Authorship 1846557
type: Authorship
author rank in publication: 6
linked author: Iliopoulos, Othon
linked information resource: The impact of surgery on patients with Von Hippel-Lindau-associated tumors: an international patient survey.

The impact of surgery on patients with Von Hippel-Lindau-associated tumors: an international patient survey.
PubMed Identifier: 40796357
author list: Sundaram M, Atkinson C, Cooper C, Taylor-Stokes G, Mann J, Iliopoulos O
published in: The oncologist
information resource reference: The impact of surgery on patients with Von Hippel-Lindau-associated tumors: an international patient survey. Oncologist. 2025 Sep 01; 30(9).
journal title abbreviation: Oncologist
publication date: 2025-09-01T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Belzutifan for Advanced Pheochromocytoma or Paraganglioma.
PubMed Identifier: 41124218
author list: Jimenez C, Andreassen M, Durand A, Moog S, Hendifar A, Welin S, Spada F, Sharma R, Wolin E, Ruether J, Garcia-Carbonero R, Fassnacht M, Capdevila J, Del Rivero J, Iliopoulos O, Huillard O, Jang R, Mai K, Artamonova E, Hallqvist A, Else T, Odeleye-Ajakaye A, Gozman A, Naik GS, Berruti A
published in: The New England journal of medicine
information resource reference: Belzutifan for Advanced Pheochromocytoma or Paraganglioma. N Engl J Med. 2025 Nov 20; 393(20):2012-2022.
journal title abbreviation: N Engl J Med
publication date: 2025-10-18T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Edward Wigglesworth Professor of Dermatology
is primary position: true
position in department: Dermatology
position in division: Cutaneous Biology Research Center
sort order: 1
type: Position
HR job title: Edward Wigglesworth Professor of Dermatology
position in organization: Massachusetts General Hospital

Cutaneous Biology Research Center
type: Division
type: Organization

Authorship 168497
type: Authorship
author rank in publication: 4
linked author: Iliopoulos, Othon
linked information resource: von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids.

Authorship 464307
type: Authorship
author rank in publication: 2
linked author: Iliopoulos, Othon
linked information resource: Cells and secretagogues involved in the human late-phase response.

Authorship 767976
type: Authorship
author rank in publication: 5
linked author: Iliopoulos, Othon
linked information resource: Comparative studies of the proteome, glycoproteome, and N-glycome of clear cell renal cell carcinoma plasma before and after curative nephrectomy.

Comparative studies of the proteome, glycoproteome, and N-glycome of clear cell renal cell carcinoma plasma before and after curative nephrectomy.
PubMed Identifier: 25184692
author list: Gbormittah FO, Lee LY, Taylor K, Hancock WS, Iliopoulos O
published in: Journal of proteome research
information resource reference: Comparative studies of the proteome, glycoproteome, and N-glycome of clear cell renal cell carcinoma plasma before and after curative nephrectomy. J Proteome Res. 2014 Nov 07; 13(11):4889-900.
journal title abbreviation: J Proteome Res
publication date: 2014-09-10T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 499877
type: Authorship
author rank in publication: 1
linked author: Iliopoulos, Othon
linked information resource: Genetic and clinical aspects of familial renal neoplasms.

Clusterin glycopeptide variant characterization reveals significant site-specific glycan changes in the plasma of clear cell renal cell carcinoma.
PubMed Identifier: 25855029
author list: Gbormittah FO, Bones J, Hincapie M, Tousi F, Hancock WS, Iliopoulos O
published in: Journal of proteome research
information resource reference: Clusterin glycopeptide variant characterization reveals significant site-specific glycan changes in the plasma of clear cell renal cell carcinoma. J Proteome Res. 2015 Jun 05; 14(6):2425-36.
journal title abbreviation: J Proteome Res
publication date: 2015-05-11T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Pharmacological HIF2a inhibition improves VHL disease-associated phenotypes in zebrafish model.
PubMed Identifier: 25866969
author list: Metelo AM, Noonan HR, Li X, Jin Y, Baker R, Kamentsky L, Zhang Y, van Rooijen E, Shin J, Carpenter AE, Yeh JR, Peterson RT, Iliopoulos O
published in: The Journal of clinical investigation
information resource reference: Pharmacological HIF2a inhibition improves VHL disease-associated phenotypes in zebrafish model. J Clin Invest. 2015 May; 125(5):1987-97.
journal title abbreviation: J Clin Invest
publication date: 2015-04-13T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 266830
type: Authorship
author rank in publication: 13
linked author: Iliopoulos, Othon
linked information resource: Innovations and challenges in renal cancer: consensus statement from the first international conference.

Authorship 183263
type: Authorship
author rank in publication: 1
linked author: Iliopoulos, Othon
linked information resource: Tumour suppression by the human von Hippel-Lindau gene product.

Authorship 227039
type: Authorship
author rank in publication: 3
linked author: Iliopoulos, Othon
linked information resource: Regulation of vascular endothelial growth factor by hypoxia and its modulation by the von Hippel-Lindau tumor suppressor gene.

Authorship 92283
type: Authorship
author rank in publication: 1
linked author: Iliopoulos, Othon
linked information resource: Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.

Authorship 237696
type: Authorship
author rank in publication: 7
linked author: Iliopoulos, Othon
linked information resource: Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential.

Authorship 339768
type: Authorship
author rank in publication: 10
linked author: Iliopoulos, Othon
linked information resource: The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix.

Authorship 264204
type: Authorship
author rank in publication: 7
linked author: Iliopoulos, Othon
linked information resource: Hypoxia-inducible factor-2alpha: effect on radiation sensitivity and differential regulation by an mTOR inhibitor.

Authorship 350600
type: Authorship
author rank in publication: 1
linked author: Iliopoulos, Othon
linked information resource: Histamine-containing cells obtained from the nose hours after antigen challenge have functional and phenotypic characteristics of basophils.

Authorship 37588
type: Authorship
author rank in publication: 12
linked author: Iliopoulos, Othon
linked information resource: In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation.

Authorship 168913
type: Authorship
author rank in publication: 6
linked author: Iliopoulos, Othon
linked information resource: Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.

Authorship 507477
type: Authorship
author rank in publication: 1
linked author: Iliopoulos, Othon
linked information resource: The molecular basis of von Hippel-Lindau disease.

Authorship 803850
type: Authorship
author rank in publication: 14
linked author: Iliopoulos, Othon
linked information resource: Hypoxia drives transient site-specific copy gain and drug-resistant gene expression.

Authorship 798106
type: Authorship
author rank in publication: 6
linked author: Iliopoulos, Othon
linked information resource: Clusterin glycopeptide variant characterization reveals significant site-specific glycan changes in the plasma of clear cell renal cell carcinoma.

Authorship 797314
type: Authorship
author rank in publication: 13
linked author: Iliopoulos, Othon
linked information resource: Pharmacological HIF2a inhibition improves VHL disease-associated phenotypes in zebrafish model.

Hypoxia drives transient site-specific copy gain and drug-resistant gene expression.
PubMed Identifier: 25995187
author list: Black JC, Atabakhsh E, Kim J, Biette KM, Van Rechem C, Ladd B, Burrowes PD, Donado C, Mattoo H, Kleinstiver BP, Song B, Andriani G, Joung JK, Iliopoulos O, Montagna C, Pillai S, Getz G, Whetstine JR
published in: Genes & development
information resource reference: Hypoxia drives transient site-specific copy gain and drug-resistant gene expression. Genes Dev. 2015 May 15; 29(10):1018-31.
journal title abbreviation: Genes Dev
publication date: 2015-05-15T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 297251
type: Authorship
author rank in publication: 3
linked author: Iliopoulos, Othon
linked information resource: Multidimensional liquid chromatography platform for profiling alterations of clusterin N-glycosylation in the plasma of patients with renal cell carcinoma.

Authorship 532408
type: Authorship
author rank in publication: 11
linked author: Iliopoulos, Othon
linked information resource: Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.

Authorship 329604
type: Authorship
author rank in publication: 13
linked author: Iliopoulos, Othon
linked information resource: The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.

Authorship 478719
type: Authorship
author rank in publication: 1
linked author: Iliopoulos, Othon
linked information resource: Molecular biology of renal cell cancer and the identification of therapeutic targets.

Authorship 837701
type: Authorship
author rank in publication: 3
linked author: Iliopoulos, Othon
linked information resource: HIF2a inhibitors for the treatment of VHL disease.

HIF2a inhibitors for the treatment of VHL disease.
PubMed Identifier: 26325097
author list: Metelo AM, Noonan H, Iliopoulos O
published in: Oncotarget
information resource reference: HIF2a inhibitors for the treatment of VHL disease. Oncotarget. 2015 Sep 15; 6(27):23036-7.
journal title abbreviation: Oncotarget
publication date: 2015-09-15T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Assistant Professor
sort order: 2
type: Faculty Rank

Associate Professor
sort order: 1
type: Faculty Rank

Fellow or Post Doc
sort order: 6
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Instructor
sort order: 4
type: Faculty Rank

Authorship 97686
type: Authorship
author rank in publication: 2
linked author: Iliopoulos, Othon
linked information resource: Molecular genetics of kidney cancer.

Authorship 570057
type: Authorship
author rank in publication: 5
linked author: Iliopoulos, Othon
linked information resource: Observations on nasal late phase reactions.

Authorship 895611
type: Authorship
author rank in publication: 6
linked author: Iliopoulos, Othon
linked information resource: Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma.

Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma.
PubMed Identifier: 27491085
author list: Noonan HR, Metelo AM, Kamei CN, Peterson RT, Drummond IA, Iliopoulos O
published in: Disease models & mechanisms
information resource reference: Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma. Dis Model Mech. 2016 08 01; 9(8):873-84.
journal title abbreviation: Dis Model Mech
publication date: 2016-08-01T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 902812
type: Authorship
author rank in publication: 4
linked author: Iliopoulos, Othon
linked information resource: Metabolic requirements for cancer cell proliferation.

Metabolic requirements for cancer cell proliferation.
PubMed Identifier: 27540483
author list: Keibler MA, Wasylenko TM, Kelleher JK, Iliopoulos O, Vander Heiden MG, Stephanopoulos G
published in: Cancer & metabolism
information resource reference: Metabolic requirements for cancer cell proliferation. Cancer Metab. 2016; 4:16.
journal title abbreviation: Cancer Metab
publication date: 2016-08-18T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 565491
type: Authorship
author rank in publication: 3
linked author: Iliopoulos, Othon
linked information resource: Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues.

Hypoxia-induced Metabolic Changes in Cancer
end date: 2017-04-30
principal investigator name: ILIOPOULOS, OTHON
start date: 2012-07-20
type: Grant
sponsor award id: R01CA160458

TUMOR SUPPRESSOR PVHL FUNCTIONAL INTERACTION WITH CUL2
end date: 2003-06-30
principal investigator name: ILIOPOULOS, OTHON
start date: 1998-07-01
type: Grant
sponsor award id: R29CA078358

DF/HCC Kidney Cancer SPORE
end date: 2026-08-31
principal investigator name: MCDERMOTT, DAVID
start date: 2003-09-18
type: Grant
sponsor award id: P50CA101942

Identification of Biomarkers for Early Detection of Renal Cell Carcinoma
end date: 2014-01-31
principal investigator name: ILIOPOULOS, OTHON
start date: 2008-09-15
type: Grant
sponsor award id: R01CA122591

Molecular targets of hypoxia in signaling cancer
end date: 2009-04-30
principal investigator name: ILIOPOULOS, OTHON
start date: 2004-07-09
type: Grant
sponsor award id: R01CA104574

Principal Investigator
type: Researcher Role
researcher role of: Iliopoulos, Othon
contributes to: Identification of Biomarkers for Early Detection of Renal Cell Carcinoma

Principal Investigator
type: Researcher Role
researcher role of: Iliopoulos, Othon
contributes to: Molecular targets of hypoxia in signaling cancer

Principal Investigator
type: Researcher Role
researcher role of: Iliopoulos, Othon
contributes to: Hypoxia-induced Metabolic Changes in Cancer

Principal Investigator
type: Researcher Role
researcher role of: Iliopoulos, Othon
contributes to: TUMOR SUPPRESSOR PVHL FUNCTIONAL INTERACTION WITH CUL2

Co-Principal Investigator
type: Researcher Role
researcher role of: Iliopoulos, Othon
contributes to: DF/HCC Kidney Cancer SPORE

Authorship 374646
type: Authorship
author rank in publication: 1
linked author: Iliopoulos, Othon
linked information resource: Nasal challenge with cold, dry air induces a late-phase reaction.

Authorship 322641
type: Authorship
author rank in publication: 2
linked author: Iliopoulos, Othon
linked information resource: Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2.

Authorship 378984
type: Authorship
author rank in publication: 4
linked author: Iliopoulos, Othon
linked information resource: Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors.

Authorship 419612
type: Authorship
author rank in publication: 2
linked author: Iliopoulos, Othon
linked information resource: Functions of the von Hippel-Lindau tumour suppressor protein.

Authorship 947581
type: Authorship
author rank in publication: 2
linked author: Iliopoulos, Othon
linked information resource: Assessment of Overall Survival, Quality of Life, and Safety Benefits Associated With New Cancer Medicines.

Assessment of Overall Survival, Quality of Life, and Safety Benefits Associated With New Cancer Medicines.
PubMed Identifier: 28033447
author list: Salas-Vega S, Iliopoulos O, Mossialos E
published in: JAMA oncology
information resource reference: Assessment of Overall Survival, Quality of Life, and Safety Benefits Associated With New Cancer Medicines. JAMA Oncol. 2017 Mar 01; 3(3):382-390.
journal title abbreviation: JAMA Oncol
publication date: 2017-03-01T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 54199
type: Authorship
author rank in publication: 13
linked author: Iliopoulos, Othon
linked information resource: Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia.

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.
PubMed Identifier: 8855223
author list: Iliopoulos O, Levy AP, Jiang C, Kaelin WG, Goldberg MA
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc Natl Acad Sci U S A. 1996 Oct 01; 93(20):10595-9.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1996-10-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2.
PubMed Identifier: 9447969
author list: Lonergan KM, Iliopoulos O, Ohh M, Kamura T, Conaway RC, Conaway JW, Kaelin WG
published in: Molecular and cellular biology
information resource reference: Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2. Mol Cell Biol. 1998 Feb; 18(2):732-41.
journal title abbreviation: Mol Cell Biol
publication date: 1998-02-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Acute renal failure following binge drinking and nonsteroidal antiinflammatory drugs.
PubMed Identifier: 1519610
author list: Wen SF, Parthasarathy R, Iliopoulos O, Oberley TD
published in: American journal of kidney diseases : the official journal of the National Kidney Foundation
information resource reference: Acute renal failure following binge drinking and nonsteroidal antiinflammatory drugs. Am J Kidney Dis. 1992 Sep; 20(3):281-5.
journal title abbreviation: Am J Kidney Dis
publication date: 1992-09-01T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of vascular endothelial growth factor by hypoxia and its modulation by the von Hippel-Lindau tumor suppressor gene.
PubMed Identifier: 9027742
author list: Levy AP, Levy NS, Iliopoulos O, Jiang C, Kaplin WG, Goldberg MA
published in: Kidney international
information resource reference: Regulation of vascular endothelial growth factor by hypoxia and its modulation by the von Hippel-Lindau tumor suppressor gene. Kidney Int. 1997 Feb; 51(2):575-8.
journal title abbreviation: Kidney Int
publication date: 1997-02-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Nasal challenge with cold, dry air induces a late-phase reaction.
PubMed Identifier: 2461672
author list: Iliopoulos O, Proud D, Norman PS, Lichtenstein LM, Kagey-Sobotka A, Naclerio RM
published in: The American review of respiratory disease
information resource reference: Nasal challenge with cold, dry air induces a late-phase reaction. Am Rev Respir Dis. 1988 Aug; 138(2):400-5.
journal title abbreviation: Am Rev Respir Dis
publication date: 1988-08-01T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 974376
type: Authorship
author rank in publication: 12
linked author: Iliopoulos, Othon
linked information resource: Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers.

Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers.
PubMed Identifier: 28346230
author list: Okazaki A, Gameiro PA, Christodoulou D, Laviollette L, Schneider M, Chaves F, Stemmer-Rachamimov A, Yazinski SA, Lee R, Stephanopoulos G, Zou L, Iliopoulos O
published in: The Journal of clinical investigation
information resource reference: Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers. J Clin Invest. 2017 May 01; 127(5):1631-1645.
journal title abbreviation: J Clin Invest
publication date: 2017-03-27T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Case records of the Massachusetts General Hospital. Case 23-2006. A 36-year-old man with numbness in the left [corrected] hand and hypertension.
PubMed Identifier: 16870919
author list: Iliopoulos O, Chan-Smutko G, Gonzalez RG, Louis DN, Stone JR
published in: The New England journal of medicine
information resource reference: Case records of the Massachusetts General Hospital. Case 23-2006. A 36-year-old man with numbness in the left [corrected] hand and hypertension. N Engl J Med. 2006 Jul 27; 355(4):394-402.
journal title abbreviation: N Engl J Med
publication date: 2006-07-27T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation.
PubMed Identifier: 9751722
author list: Iliopoulos O, Ohh M, Kaelin WG
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11661-6.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1998-09-29T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

von Hippel-Lindau disease: genetic and clinical observations.
PubMed Identifier: 11443850
author list: Iliopoulos O
published in: Frontiers of hormone research
information resource reference: von Hippel-Lindau disease: genetic and clinical observations. Front Horm Res. 2001; 28:131-66.
journal title abbreviation: Front Horm Res
publication date: 2001-01-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Functions of the von Hippel-Lindau tumour suppressor protein.
PubMed Identifier: 9681855
author list: Kaelin WG, Iliopoulos O, Lonergan KM, Ohh M
published in: Journal of internal medicine
information resource reference: Functions of the von Hippel-Lindau tumour suppressor protein. J Intern Med. 1998 Jun; 243(6):535-9.
journal title abbreviation: J Intern Med
publication date: 1998-06-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer.
PubMed Identifier: 14996738
author list: Mizukami Y, Li J, Zhang X, Zimmer MA, Iliopoulos O, Chung DC
published in: Cancer research
information resource reference: Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res. 2004 Mar 01; 64(5):1765-72.
journal title abbreviation: Cancer Res
publication date: 2004-03-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Effects of immunotherapy on the early, late, and rechallenge nasal reaction to provocation with allergen: changes in inflammatory mediators and cells.
PubMed Identifier: 2013680
author list: Iliopoulos O, Proud D, Adkinson NF, Creticos PS, Norman PS, Kagey-Sobotka A, Lichtenstein LM, Naclerio RM
published in: The Journal of allergy and clinical immunology
information resource reference: Effects of immunotherapy on the early, late, and rechallenge nasal reaction to provocation with allergen: changes in inflammatory mediators and cells. J Allergy Clin Immunol. 1991 Apr; 87(4):855-66.
journal title abbreviation: J Allergy Clin Immunol
publication date: 1991-04-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix.
PubMed Identifier: 9651579
author list: Ohh M, Yauch RL, Lonergan KM, Whaley JM, Stemmer-Rachamimov AO, Louis DN, Gavin BJ, Kley N, Kaelin WG, Iliopoulos O
published in: Molecular cell
information resource reference: The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol Cell. 1998 Jun; 1(7):959-68.
journal title abbreviation: Mol Cell
publication date: 1998-06-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.
PubMed Identifier: 19111663
author list: Zimmer M, Ebert BL, Neil C, Brenner K, Papaioannou I, Melas A, Tolliday N, Lamb J, Pantopoulos K, Golub T, Iliopoulos O
published in: Molecular cell
information resource reference: Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing. Mol Cell. 2008 Dec 26; 32(6):838-48.
journal title abbreviation: Mol Cell
publication date: 2008-12-26T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular biology of renal cell cancer and the identification of therapeutic targets.
PubMed Identifier: 17158545
author list: Iliopoulos O
published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
information resource reference: Molecular biology of renal cell cancer and the identification of therapeutic targets. J Clin Oncol. 2006 Dec 10; 24(35):5593-600.
journal title abbreviation: J Clin Oncol
publication date: 2006-12-10T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 988714
type: Authorship
author rank in publication: 9
linked author: Iliopoulos, Othon
linked information resource: Early onset renal cell carcinoma in an adolescent girl with germline FLCN exon 5 deletion.

Early onset renal cell carcinoma in an adolescent girl with germline FLCN exon 5 deletion.
PubMed Identifier: 28623476
author list: Schneider M, Dinkelborg K, Xiao X, Chan-Smutko G, Hruska K, Huang D, Sagar P, Harisinghani M, Iliopoulos O
published in: Familial cancer
information resource reference: Early onset renal cell carcinoma in an adolescent girl with germline FLCN exon 5 deletion. Fam Cancer. 2018 01; 17(1):135-139.
journal title abbreviation: Fam Cancer
publication date: 2018-01-01T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 993052
type: Authorship
author rank in publication: 13
linked author: Iliopoulos, Othon
linked information resource: Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein.

Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein.
PubMed Identifier: 28656962
author list: Laviolette LA, Mermoud J, Calvo IA, Olson N, Boukhali M, Steinlein OK, Roider E, Sattler EC, Huang D, Teh BT, Motamedi M, Haas W, Iliopoulos O
published in: Nature communications
information resource reference: Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein. Nat Commun. 2017 06 28; 8:15866.
journal title abbreviation: Nat Commun
publication date: 2017-06-28T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C.
PubMed Identifier: 7660130
author list: Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG
published in: Science (New York, N.Y.)
information resource reference: Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C. Science. 1995 Sep 08; 269(5229):1444-6.
journal title abbreviation: Science
publication date: 1995-09-08T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Cells and secretagogues involved in the human late-phase response.
PubMed Identifier: 2468620
author list: Charlesworth EN, Iliopoulos O, MacDonald SM, Kagey-Sobotka A, Lichtenstein LM
published in: International archives of allergy and applied immunology
information resource reference: Cells and secretagogues involved in the human late-phase response. Int Arch Allergy Appl Immunol. 1989; 88(1-2):50-3.
journal title abbreviation: Int Arch Allergy Appl Immunol
publication date: 1989-01-01T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

55 Fruit St
type: Address
address line 1: Massachusetts General Hospital
address line 2: Grj 904
address line 3: 55 Fruit St
city: Boston
postal code: 02114
state or province: MA

Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential.
PubMed Identifier: 21836617
author list: Heddleston JM, Wu Q, Rivera M, Minhas S, Lathia JD, Sloan AE, Iliopoulos O, Hjelmeland AB, Rich JN
published in: Cell death and differentiation
information resource reference: Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential. Cell Death Differ. 2012 Mar; 19(3):428-39.
journal title abbreviation: Cell Death Differ
publication date: 2011-08-12T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Chemical Biology of IRP1-HIF2a Signaling
end date: 2022-04-30
principal investigator name: ILIOPOULOS, OTHON
start date: 2017-05-01
type: Grant
sponsor award id: R01CA215431

Principal Investigator
type: Researcher Role
researcher role of: Iliopoulos, Othon
contributes to: Chemical Biology of IRP1-HIF2a Signaling

The molecular basis of von Hippel-Lindau disease.
PubMed Identifier: 9205944
author list: Iliopoulos O, Kaelin WG
published in: Molecular medicine (Cambridge, Mass.)
information resource reference: The molecular basis of von Hippel-Lindau disease. Mol Med. 1997 May; 3(5):289-93.
journal title abbreviation: Mol Med
publication date: 1997-05-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors.
PubMed Identifier: 14985465
author list: Zimmer M, Doucette D, Siddiqui N, Iliopoulos O
published in: Molecular cancer research : MCR
information resource reference: Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors. Mol Cancer Res. 2004 Feb; 2(2):89-95.
journal title abbreviation: Mol Cancer Res
publication date: 2004-02-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells.
PubMed Identifier: 16127434
author list: Mizukami Y, Jo WS, Duerr EM, Gala M, Li J, Zhang X, Zimmer MA, Iliopoulos O, Zukerberg LR, Kohgo Y, Lynch MP, Rueda BR, Chung DC
published in: Nature medicine
information resource reference: Induction of interleukin-8 preserves the angiogenic response in HIF-1alpha-deficient colon cancer cells. Nat Med. 2005 Sep; 11(9):992-7.
journal title abbreviation: Nat Med
publication date: 2005-08-28T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Case records of the Massachusetts General Hospital. Case 17-2008. A 63-year-old man with metastatic renal-cell carcinoma.
PubMed Identifier: 18509125
author list: Michaelson MD, Iliopoulos O, McDermott DF, McGovern FJ, Harisinghani MG, Oliva E
published in: The New England journal of medicine
information resource reference: Case records of the Massachusetts General Hospital. Case 17-2008. A 63-year-old man with metastatic renal-cell carcinoma. N Engl J Med. 2008 May 29; 358(22):2389-96.
journal title abbreviation: N Engl J Med
publication date: 2008-05-29T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Loss of RBF1 changes glutamine catabolism.
PubMed Identifier: 23322302
author list: Nicolay BN, Gameiro PA, Tschöp K, Korenjak M, Heilmann AM, Asara JM, Stephanopoulos G, Iliopoulos O, Dyson NJ
published in: Genes & development
information resource reference: Loss of RBF1 changes glutamine catabolism. Genes Dev. 2013 Jan 15; 27(2):182-96.
journal title abbreviation: Genes Dev
publication date: 2013-01-15T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.
PubMed Identifier: 20141841
author list: Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R
published in: Cell
information resource reference: The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell. 2010 Jan 22; 140(2):280-93.
journal title abbreviation: Cell
publication date: 2010-01-22T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Studies on the allergic and nonallergic nasal inflammation.
PubMed Identifier: 3286718
author list: Togias A, Naclerio RM, Proud D, Pipkorn U, Bascom R, Iliopoulos O, Kagey-Sobotka A, Norman PS, Lichtenstein LM
published in: The Journal of allergy and clinical immunology
information resource reference: Studies on the allergic and nonallergic nasal inflammation. J Allergy Clin Immunol. 1988 May; 81(5 Pt 1):782-90.
journal title abbreviation: J Allergy Clin Immunol
publication date: 1988-05-01T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

Relationship between the early, late, and rechallenge reaction to nasal challenge with antigen: observations on the role of inflammatory mediators and cells.
PubMed Identifier: 2262642
author list: Iliopoulos O, Proud D, Adkinson NF, Norman PS, Kagey-Sobotka A, Lichtenstein LM, Naclerio RM
published in: The Journal of allergy and clinical immunology
information resource reference: Relationship between the early, late, and rechallenge reaction to nasal challenge with antigen: observations on the role of inflammatory mediators and cells. J Allergy Clin Immunol. 1990 Dec; 86(6 Pt 1):851-61.
journal title abbreviation: J Allergy Clin Immunol
publication date: 1990-12-01T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Hypoxia-inducible factor-2alpha: effect on radiation sensitivity and differential regulation by an mTOR inhibitor.
PubMed Identifier: 18394010
author list: Bhatt RS, Landis DM, Zimmer M, Torregrossa J, Chen S, Sukhatme VP, Iliopoulos O, Balk S, Bubley GJ
published in: BJU international
information resource reference: Hypoxia-inducible factor-2alpha: effect on radiation sensitivity and differential regulation by an mTOR inhibitor. BJU Int. 2008 Aug; 102(3):358-63.
journal title abbreviation: BJU Int
publication date: 2008-04-03T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2.
PubMed Identifier: 20354189
author list: Zimmer M, Lamb J, Ebert BL, Lynch M, Neil C, Schmidt E, Golub TR, Iliopoulos O
published in: Cancer research
information resource reference: The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. Cancer Res. 2010 Apr 15; 70(8):3071-9.
journal title abbreviation: Cancer Res
publication date: 2010-03-30T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Histamine-containing cells obtained from the nose hours after antigen challenge have functional and phenotypic characteristics of basophils.
PubMed Identifier: 1372025
author list: Iliopoulos O, Baroody FM, Naclerio RM, Bochner BS, Kagey-Sobotka A, Lichtenstein LM
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Histamine-containing cells obtained from the nose hours after antigen challenge have functional and phenotypic characteristics of basophils. J Immunol. 1992 Apr 01; 148(7):2223-8.
journal title abbreviation: J Immunol
publication date: 1992-04-01T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues.
PubMed Identifier: 9104946
author list: Corless CL, Kibel AS, Iliopoulos O, Kaelin WG
published in: Human pathology
information resource reference: Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues. Hum Pathol. 1997 Apr; 28(4):459-64.
journal title abbreviation: Hum Pathol
publication date: 1997-04-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

How many pathways to pheochromocytoma?
PubMed Identifier: 11891502
author list: Neumann HP, Hoegerle S, Manz T, Brenner K, Iliopoulos O
published in: Seminars in nephrology
information resource reference: How many pathways to pheochromocytoma? Semin Nephrol. 2002 Mar; 22(2):89-99.
journal title abbreviation: Semin Nephrol
publication date: 2002-03-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 100481
type: Authorship
author rank in publication: 1
linked author: Iliopoulos, Othon
linked information resource: Relationship between the early, late, and rechallenge reaction to nasal challenge with antigen: observations on the role of inflammatory mediators and cells.

von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids.
PubMed Identifier: 9810005
author list: Lieubeau-Teillet B, Rak J, Jothy S, Iliopoulos O, Kaelin W, Kerbel RS
published in: Cancer research
information resource reference: von Hippel-Lindau gene-mediated growth suppression and induction of differentiation in renal cell carcinoma cells grown as multicellular tumor spheroids. Cancer Res. 1998 Nov 01; 58(21):4957-62.
journal title abbreviation: Cancer Res
publication date: 1998-11-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 101082
type: Authorship
author rank in publication: 5
linked author: Iliopoulos, Othon
linked information resource: How many pathways to pheochromocytoma?