HL55HongboLuoHongbo Luo, Ph.D.42.33812600000000-71.1049210000000069280Luo, Hongbo617/919-2303Professor of Pathologycatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:trainingAtOrganizationeducational organizationprns:trainingLocationtraining locationprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:degreeEarneddegree earnedDepartmentDivisionvivo:educationalTrainingeducation and trainingEducational TrainingGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:majorFieldmajor field of degreevivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 1046314727322080Li Z, Ye Z, Zhang X, Zhang Q, Fan D, Zhang Y, Luo HR, Yuan X, Li Z, Xiong DOncotargetE1A-engineered human umbilical cord mesenchymal stem cells as carriers and amplifiers for adenovirus suppress hepatocarcinoma in mice. Oncotarget. 2016 Aug 09; 7(32):51815-51828.Oncotarget2016-08-09T00:00:002016E1A-engineered human umbilical cord mesenchymal stem cells as carriers and amplifiers for adenovirus suppress hepatocarcinoma in mice.Authorship 10515641529539421Kambara H, Liu F, Zhang X, Liu P, Bajrami B, Teng Y, Zhao L, Zhou S, Yu H, Zhou W, Silberstein LE, Cheng T, Han M, Xu Y, Luo HRCell reportsGasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death. Cell Rep. 2018 03 13; 22(11):2924-2936.Cell Rep2018-03-13T00:00:002018Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death.Authorship 10563431129618559Hou Q, Liu F, Chakraborty A, Jia Y, Prasad A, Yu H, Zhao L, Ye K, Snyder SH, Xu Y, Luo HRScience translational medicineInhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia. Sci Transl Med. 2018 04 04; 10(435).Sci Transl Med2018-04-04T00:00:002018Inhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia.16988010Zhu D, Hattori H, Jo H, Jia Y, Subramanian KK, Loison F, You J, Le Y, Honczarenko M, Silberstein L, Luo HRProceedings of the National Academy of Sciences of the United States of AmericaDeactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death. Proc Natl Acad Sci U S A. 2006 Oct 03; 103(40):14836-41.Proc Natl Acad Sci U S A2006-09-20T00:00:002006Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death.17924549Luo HR, Loison FAmerican journal of hematologyConstitutive neutrophil apoptosis: mechanisms and regulation. Am J Hematol. 2008 Apr; 83(4):288-95.Am J Hematol2008-04-01T00:00:002008Constitutive neutrophil apoptosis: mechanisms and regulation.18374643Liu Z, Jang SW, Liu X, Cheng D, Peng J, Yepes M, Li XJ, Matthews S, Watts C, Asano M, Hara-Nishimura I, Luo HR, Ye KMolecular cellNeuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase. Mol Cell. 2008 Mar 28; 29(6):665-78.Mol Cell2008-03-28T00:00:002008Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase.19286998Li Y, Jia Y, Pichavant M, Loison F, Sarraj B, Kasorn A, You J, Robson BE, Umetsu DT, Mizgerd JP, Ye K, Luo HRBloodTargeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia. Blood. 2009 May 14; 113(20):4930-41.Blood2009-03-13T00:00:002009Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia.19561112Kasorn A, Alcaide P, Jia Y, Subramanian KK, Sarraj B, Li Y, Loison F, Hattori H, Silberstein LE, Luscinskas WF, Luo HRJournal of immunology (Baltimore, Md. : 1950)Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals. J Immunol. 2009 Jul 15; 183(2):1032-43.J Immunol2009-06-26T00:00:002009Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals.Authorship 10629741029719252Yim SH, Everley RA, Schildberg FA, Lee SG, Orsi A, Barbati ZR, Karatepe K, Fomenko DE, Tsuji PA, Luo HR, Gygi SP, Sitia R, Sharpe AH, Hatfield DL, Gladyshev VNCell reportsRole of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins. Cell Rep. 2018 05 01; 23(5):1387-1398.Cell Rep2018-05-01T00:00:002018Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins.17202315Subramanian KK, Jia Y, Zhu D, Simms BT, Jo H, Hattori H, You J, Mizgerd JP, Luo HRBloodTumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions. Blood. 2007 May 01; 109(9):4028-37.Blood2007-01-03T00:00:002007Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions.17234578Huang Y, Kang BN, Tian J, Liu Y, Luo HR, Hester L, Snyder SHThe Journal of neuroscience : the official journal of the Society for NeuroscienceThe cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway. J Neurosci. 2007 Jan 17; 27(3):449-58.J Neurosci2007-01-17T00:00:002007The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway.17420285Hattori H, Zhang X, Jia Y, Subramanian KK, Jo H, Loison F, Newburger PE, Luo HRBloodRNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells. Blood. 2007 Jul 15; 110(2):640-50.Blood2007-04-09T00:00:002007RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells.17709751Maréchal Y, Pesesse X, Jia Y, Pouillon V, Pérez-Morga D, Daniel J, Izui S, Cullen PJ, Leo O, Luo HR, Erneux C, Schurmans SProceedings of the National Academy of Sciences of the United States of AmericaInositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):13978-83.Proc Natl Acad Sci U S A2007-08-20T00:00:002007Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells.20142487Hattori H, Subramanian KK, Sakai J, Jia Y, Li Y, Porter TF, Loison F, Sarraj B, Kasorn A, Jo H, Blanchard C, Zirkle D, McDonald D, Pai SY, Serhan CN, Luo HRProceedings of the National Academy of Sciences of the United States of AmericaSmall-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3546-51.Proc Natl Acad Sci U S A2010-02-08T00:00:002010Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis.Authorship 1068019929793924Kanneganti A, Malireddi RKS, Saavedra PHV, Vande Walle L, Van Gorp H, Kambara H, Tillman H, Vogel P, Luo HR, Xavier RJ, Chi H, Lamkanfi MThe Journal of experimental medicineGSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever. J Exp Med. 2018 06 04; 215(6):1519-1529.J Exp Med2018-05-23T00:00:002018GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever.21908618He K, Chan CB, Liu X, Jia Y, Luo HR, France SA, Liu Y, Wilson WD, Ye KThe Journal of biological chemistryIdentification of a molecular activator for insulin receptor with potent anti-diabetic effects. J Biol Chem. 2011 Oct 28; 286(43):37379-88.J Biol Chem2011-09-09T00:00:002011Identification of a molecular activator for insulin receptor with potent anti-diabetic effects.22689977Jo H, Mondal S, Tan D, Nagata E, Takizawa S, Sharma AK, Hou Q, Shanmugasundaram K, Prasad A, Tung JK, Tejeda AO, Man H, Rigby AC, Luo HRProceedings of the National Academy of Sciences of the United States of AmericaSmall molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):10581-6.Proc Natl Acad Sci U S A2012-06-11T00:00:002012Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death.14504398Luo HR, Hattori H, Hossain MA, Hester L, Huang Y, Lee-Kwon W, Donowitz M, Nagata E, Snyder SHProceedings of the National Academy of Sciences of the United States of AmericaAkt as a mediator of cell death. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11712-7.Proc Natl Acad Sci U S A2003-09-22T00:00:002003Akt as a mediator of cell death.Authorship 1074646729896294Yan B, Xie S, Liu Y, Liu W, Li D, Liu M, Luo HR, Zhou JTheranosticsHistone deacetylase 6 modulates macrophage infiltration during inflammation. Theranostics. 2018; 8(11):2927-2938.Theranostics2018-04-18T00:00:002018Histone deacetylase 6 modulates macrophage infiltration during inflammation.23287862Gao C, Dimitrov T, Yong KJ, Tatetsu H, Jeong HW, Luo HR, Bradner JE, Tenen DG, Chai LBloodTargeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex. Blood. 2013 Feb 21; 121(8):1413-21.Blood2013-01-03T00:00:002013Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex.22984948Liu X, Chan CB, Qi Q, Xiao G, Luo HR, He X, Ye KJournal of medicinal chemistryOptimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression. J Med Chem. 2012 Oct 11; 55(19):8524-37.J Med Chem2012-10-03T00:00:002012Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression.21464312Jo H, Lo PK, Li Y, Loison F, Green S, Wang J, Silberstein LE, Ye K, Chen H, Luo HRProceedings of the National Academy of Sciences of the United States of AmericaDeactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6486-91.Proc Natl Acad Sci U S A2011-04-04T00:00:002011Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.Authorship 10857431730059535Liu NN, Uppuluri P, Broggi A, Besold A, Ryman K, Kambara H, Solis N, Lorenz V, Qi W, Acosta-Zaldívar M, Emami SN, Bao B, An D, Bonilla FA, Sola-Visner M, Filler SG, Luo HR, Engström Y, Ljungdahl PO, Culotta VC, Zanoni I, Lopez-Ribot JL, Köhler JRPLoS pathogensIntersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence. PLoS Pathog. 2018 07; 14(7):e1007076.PLoS Pathog2018-07-30T00:00:002018Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence.22323291Mondal S, Subramanian KK, Sakai J, Bajrami B, Luo HRMolecular biology of the cellPhosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion. Mol Biol Cell. 2012 Apr; 23(7):1219-30.Mol Biol Cell2012-02-09T00:00:002012Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion.21632930Chan CB, Liu X, Pradoldej S, Hao C, An J, Yepes M, Luo HR, Ye KThe Journal of neuroscience : the official journal of the Society for NeurosciencePhosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex. J Neurosci. 2011 Jun 01; 31(22):8083-92.J Neurosci2011-06-01T00:00:002011Phosphoinositide 3-kinase enhancer regulates neuronal dendritogenesis and survival in neocortex.23196464Takizawa S, Nagata E, Luo HRRinsho shinkeigaku = Clinical neurology[Novel neuroprotective agents: a HIF activator and an Akt activator]. Rinsho Shinkeigaku. 2012; 52(11):911-2.Rinsho Shinkeigaku2012-01-01T00:00:002012[Novel neuroprotective agents: a HIF activator and an Akt activator].Authorship 10969241330262562Wang X, Gao Y, Gao J, Li M, Zhou M, Wang J, Pang Y, Cheng H, Yuan C, Chu Y, Jiang Y, Zhou J, Luo HR, Ju Z, Cheng T, Yuan WHaematologicaRheb1 loss leads to increased hematopoietic stem cell proliferation and myeloid-biased differentiation in vivo. Haematologica. 2019 02; 104(2):245-255.Haematologica2018-09-27T00:00:002018Rheb1 loss leads to increased hematopoietic stem cell proliferation and myeloid-biased differentiation in vivo.Authorship 11112675Authorship 11105971530392974Karatepe K, Zhu H, Zhang X, Guo R, Kambara H, Loison F, Liu P, Yu H, Ren Q, Luo X, Manis J, Cheng T, Ma F, Xu Y, Luo HRStem cell reportsProteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow. Stem Cell Reports. 2018 11 13; 11(5):1092-1105.Stem Cell Reports2018-11-01T00:00:002018Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow.30407218Zhang X, Guo R, Kambara H, Ma F, Luo HRCurrent opinion in hematologyThe role of CXCR2 in acute inflammatory responses and its antagonists as anti-inflammatory therapeutics. Curr Opin Hematol. 2019 01; 26(1):28-33.Curr Opin Hematol2019-01-01T00:00:002019The role of CXCR2 in acute inflammatory responses and its antagonists as anti-inflammatory therapeutics.18769148Jia Y, Schurmans S, Luo HRCell cycle (Georgetown, Tex.)Regulation of innate immunity by inositol 1,3,4,5-tetrakisphosphate. Cell Cycle. 2008 Sep 15; 7(18):2803-8.Cell Cycle2008-09-15T00:00:002008Regulation of innate immunity by inositol 1,3,4,5-tetrakisphosphate.Authorship 1123241830598505You Y, Chen J, Zhu F, Xu Q, Han L, Gao X, Zhang X, Luo HR, Miao J, Sun X, Ren H, Du Y, Guo L, Wang X, Wang Y, Chen S, Huang N, Li JThe Journal of biological chemistryGlutaredoxin 1 up-regulates deglutathionylation of a4 integrin and thereby restricts neutrophil mobilization from bone marrow. J Biol Chem. 2019 02 22; 294(8):2616-2627.J Biol Chem2018-12-31T00:00:002018Glutaredoxin 1 up-regulates deglutathionylation of a4 integrin and thereby restricts neutrophil mobilization from bone marrow.2023-12-31LUO, HONGBO R2019-01-02Cell-based high-throughput chemical genetic screening for GSDMD inhibitorsR01AI141386Principal Investigator18031698Le Y, Zhu BM, Harley B, Park SY, Kobayashi T, Manis JP, Luo HR, Yoshimura A, Hennighausen L, Silberstein LEImmunitySOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis. Immunity. 2007 Nov; 27(5):811-23.Immunity2007-11-01T00:00:002007SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis.1992Nankai UniversityChinaNankai University, Molecular BiologyB.SMolecular Biology1999Brandeis University and HHMIBrandeis University and HHMI, Molecular and Cell BiologyPh.D.Molecular and Cell Biology2004Johns Hopkins Medical School Johns Hopkins Medical School , Molecular PharmacologyPost-DocMolecular PharmacologyD007295Chemicals & Drugs921800.950871Inositol PhosphatesD009504Anatomy126836980.398241NeutrophilsD018129Chemicals & Drugs992090.908674Phosphatidylinositol PhosphatesD017382Chemicals & Drugs108320840.557753Reactive Oxygen SpeciesD051059Chemicals & Drugs54011420.630712PTEN PhosphohydrolaseAnaesthesiaEmeritusMedicinePathologyPediatricsPsychiatryStem Cell and Regenerative BiologySurgeryCardiologyImmunologyBrigham and Women's HospitalBoston Children's HospitalHarvard Medical SchoolMassachusetts General HospitalBHE3BEllisB Heidi Ellis, Ph.D.42.33812600000000-71.1049210000000084130Ellis, BAssociate Professor of Psychology in the Department of PsychiatryPL2PeterLibbyPeter Libby, M.D.42.33510370000000-71.1061649000000058636Libby, PeterMallinckrodt Professor of MedicineCNS3CharlesSerhanCharles Nicholas Serhan, Ph.D.42.33510370000000-71.1061649000000017417Serhan, CharlesSimon Gelman Professor of AnaesthesiaDI4DanielIrimiaDaniel Irimia, M.D., Ph.D.42.37904200000000-71.0514810000000011972Irimia, DanielAssociate Professor of SurgeryDTS1DavidScaddenDavid Scadden, M.D.42.37730000000000-71.0525000000000014424Scadden, DavidProfessor of Stem Cell and Regenerative BiologyPJS13PaulSchmidtPaul Jeffrey Schmidt, Ph.D.42.33812600000000-71.1049210000000015312Schmidt, PaulPrincipal Associate in PathologySP13Shin-YoungParkShin-Young Park, Ph.D.42.33812600000000-71.1049210000000051598Park, Shin-YoungInstructor in PathologyLC65LiChaiLi Chai, M.D.42.33510370000000-71.1061649000000037076Chai, LiAssociate Professor of Pathology1196selected publications4.911590.00321432533research areas2.16810.022319452coauthor of96.273416.419660similar toRSG3RaifGehaRaif Salim Geha, M.D.42.33812600000000-71.1049210000000064430Geha, RaifJames L. Gamble Professor of Pediatrics2024-05-31LUO, HONGBO R2019-06-12Regulation of IL-1β bioactivity by Cysteine S-glutathionylationR01AI142642Principal InvestigatorJPM6JohnManisJohn P. Manis, M.D.42.33812600000000-71.1049210000000013448Manis, JohnAssociate Professor of PathologyLIZ1LeonardZonLeonard Ira Zon, M.D.42.33743600000000-71.1054470000000060887Zon, LeonardProfessor of Stem Cell and Regenerative BiologyLES4LeslieSilbersteinLeslie E. Silberstein, M.D.42.33812600000000-71.1049210000000049404Silberstein, LeslieProfessor of Pathology, Emeritus2024-08-31LUO, HONGBO R2019-09-20Regulation of neutrophil death by GSDMD in Candida albicans infectionR01AI145274Principal Investigatortrue1Mallinckrodt Professor of MedicineMallinckrodt Professor of Medicinetrue1Associate Professor of PathologyAssociate Professor of Pathologytrue1Associate Professor of SurgeryAssociate Professor of Surgerytrue1Simon Gelman Professor of AnaesthesiaSimon Gelman Professor of AnaesthesiaAuthorship 1206805731793911Kang SS, Liu X, Ahn EH, Xiang J, Manfredsson FP, Yang X, Luo HR, Liles LC, Weinshenker D, Ye KThe Journal of clinical investigationNorepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus. J Clin Invest. 2020 01 02; 130(1):422-437.J Clin Invest2020-01-02T00:00:002020Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus.LG222LaxmanGhimireLaxman Ghimire, Ph.D.186505Ghimire, LaxmanResearch Fellow in PathologyAuthorship 1223705832024607Wang Y, Sun X, Yuan S, Hou S, Guo T, Chu Y, Pang T, Luo HR, Yuan W, Wang XCytotherapyInterleukin-1ß inhibits normal hematopoietic expansion and promotes acute myeloid leukemia progression via the bone marrow niche. Cytotherapy. 2020 03; 22(3):127-134.Cytotherapy2020-02-03T00:00:002020Interleukin-1ß inhibits normal hematopoietic expansion and promotes acute myeloid leukemia progression via the bone marrow niche.Authorship 1739199Authorship 124484814Authorship 12457331532373117Zhang X, Karatepe K, Chiewchengchol D, Zhu H, Guo R, Liu P, Yu H, Ren Q, Luo X, Cheng T, Ma F, Xu Y, Han M, Luo HRFrontiers in immunologyBacteria-Induced Acute Inflammation Does Not Reduce the Long-Term Reconstitution Capacity of Bone Marrow Hematopoietic Stem Cells. Front Immunol. 2020; 11:626.Front Immunol2020-04-16T00:00:002020Bacteria-Induced Acute Inflammation Does Not Reduce the Long-Term Reconstitution Capacity of Bone Marrow Hematopoietic Stem Cells.32367036Hu JJ, Liu X, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, Kim J, Lieberman J, Wu HNature immunologyFDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nat Immunol. 2020 07; 21(7):736-745.Nat Immunol2020-05-04T00:00:002020FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation.23725762Liang OD, Lu J, Nombela-Arrieta C, Zhong J, Zhao L, Pivarnik G, Mondal S, Chai L, Silberstein LE, Luo HRDevelopmental cellDeficiency of lipid phosphatase SHIP enables long-term reconstitution of hematopoietic inductive bone marrow microenvironment. Dev Cell. 2013 May 28; 25(4):333-49.Dev Cell2013-05-28T00:00:002013Deficiency of lipid phosphatase SHIP enables long-term reconstitution of hematopoietic inductive bone marrow microenvironment.Authorship 1414093alh838AlanHsuAlan Yi-Hui Hsu, Ph.D.192202Hsu, AlanResearch Fellow in PathologyAuthorship 12718181732719519Xie X, Shi Q, Wu P, Zhang X, Kambara H, Su J, Yu H, Park SY, Guo R, Ren Q, Zhang S, Xu Y, Silberstein LE, Cheng T, Ma F, Li C, Luo HRNature immunologySingle-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection. Nat Immunol. 2020 09; 21(9):1119-1133.Nat Immunol2020-07-27T00:00:002020Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection.Authorship 13171831333406418Kong NR, Bassal MA, Tan HK, Kurland JV, Yong KJ, Young JJ, Yang Y, Li F, Lee JD, Liu Y, Wu CS, Stein A, Luo HR, Silberstein LE, Bulyk ML, Tenen DG, Chai LCell reportsZinc Finger Protein SALL4 Functions through an AT-Rich Motif to Regulate Gene Expression. Cell Rep. 2021 01 05; 34(1):108574.Cell Rep2021-01-05T00:00:002021Zinc Finger Protein SALL4 Functions through an AT-Rich Motif to Regulate Gene Expression.33627408Zhang Y, Xie X, Yeganeh PN, Lee DJ, Valle-Garcia D, Meza-Sosa KF, Junqueira C, Su J, Luo HR, Hide W, Lieberman JProceedings of the National Academy of Sciences of the United States of AmericaImmunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown. Proc Natl Acad Sci U S A. 2021 03 02; 118(9).Proc Natl Acad Sci U S A2021-03-02T00:00:002021Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown.Authorship 13333069Authorship 13648151134124040Gao J, Hou S, Yuan S, Wang Y, Gao Y, Sun X, Wang W, Chu Y, Zhou Y, Feng X, Luo HR, Cheng T, Shi J, Yuan W, Wang XFrontiers in cell and developmental biologyRheb1-Deficient Neutrophils Promote Hematopoietic Stem/Progenitor Cell Proliferation via Mesenchymal Stem Cells. Front Cell Dev Biol. 2021; 9:650599.Front Cell Dev Biol2021-05-27T00:00:002021Rheb1-Deficient Neutrophils Promote Hematopoietic Stem/Progenitor Cell Proliferation via Mesenchymal Stem Cells.Authorship 13803592034321317Fan Y, Teng Y, Loison F, Pang A, Kasorn A, Shao X, Zhang C, Ren Q, Yu H, Zheng Y, Cancelas JA, Manis J, Chai L, Park SY, Zhao L, Xu Y, Feng S, Silberstein LE, Ma F, Luo HRScience translational medicineTargeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion. Sci Transl Med. 2021 07 28; 13(604).Sci Transl Med2021-07-28T00:00:002021Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion.Authorship 1405811834688035Wang T, Zhou P, Xie X, Tomita Y, Cho S, Tsirukis D, Lam E, Luo HR, Sun YEBioMedicineMyeloid lineage contributes to pathological choroidal neovascularization formation via SOCS3. EBioMedicine. 2021 Nov; 73:103632.EBioMedicine2021-10-21T00:00:002021Myeloid lineage contributes to pathological choroidal neovascularization formation via SOCS3.Authorship 14109621934795266Ding X, Kambara H, Guo R, Kanneganti A, Acosta-Zaldívar M, Li J, Liu F, Bei T, Qi W, Xie X, Han W, Liu N, Zhang C, Zhang X, Yu H, Zhao L, Ma F, Köhler JR, Luo HRNature communicationsInflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages. Nat Commun. 2021 11 18; 12(1):6699.Nat Commun2021-11-18T00:00:002021Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages.Authorship 14455261035464448Wang G, Zhang C, Kambara H, Dambrot C, Xie X, Zhao L, Xu R, Oneglia A, Liu F, Luo HRFrontiers in immunologyIdentification of the Transgene Integration Site and Host Genome Changes in MRP8-Cre/ires-EGFP Transgenic Mice by Targeted Locus Amplification. Front Immunol. 2022; 13:875991.Front Immunol2022-04-06T00:00:002022Identification of the Transgene Integration Site and Host Genome Changes in MRP8-Cre/ires-EGFP Transgenic Mice by Targeted Locus Amplification.Authorship 3041010Authorship 3365921136332166Liu F, Ghimire L, Balasubramanian A, Hsu AY, Zhang Z, Yu H, Ma F, Luo HRBloodNeutrophil-specific depletion of gasdermin D does not protect against murine sepsis. Blood. 2023 02 02; 141(5):550-554.Blood2023-02-02T00:00:002023Neutrophil-specific depletion of gasdermin D does not protect against murine sepsis.Authorship 1509095536466931Koutsogiannaki S, Hou L, Okuno T, Shibamura-Fujiogi M, Luo HR, Yuki KFrontiers in immunologyaDß2 as a novel target of experimental polymicrobial sepsis. Front Immunol. 2022; 13:1059996.Front Immunol2022-11-18T00:00:002022aDß2 as a novel target of experimental polymicrobial sepsis.Authorship 4737449Authorship 504209Authorship 15503868Authorship 2813257Authorship 159030018Authorship 15822501037603754Van Bruggen S, Jarrot PA, Thomas E, Sheehy CE, Silva CMS, Hsu AY, Cunin P, Nigrovic PA, Gomes ER, Luo HR, Waterman CM, Wagner DDProceedings of the National Academy of Sciences of the United States of AmericaNLRP3 is essential for neutrophil polarization and chemotaxis in response to leukotriene B4 gradient. Proc Natl Acad Sci U S A. 2023 08 29; 120(35):e2303814120.Proc Natl Acad Sci U S A2023-08-21T00:00:002023NLRP3 is essential for neutrophil polarization and chemotaxis in response to leukotriene B4 gradient.37642636Yang J, Liu Y, Yin H, Xie S, Zhang L, Dong X, Ni H, Bu W, Ma H, Liu P, Zhu H, Guo R, Sun L, Wu Y, Qin J, Sun B, Li D, Luo HR, Liu M, Xuan C, Zhou JEMBO reportsHDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells. EMBO Rep. 2023 10 09; 24(10):e56009.EMBO Rep2023-08-29T00:00:002023HDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells.Authorship 381010Authorship 4219969Authorship 16199801238195694Ma F, Ghimire L, Ren Q, Fan Y, Chen T, Balasubramanian A, Hsu A, Liu F, Yu H, Xie X, Xu R, Luo HRNature communicationsGasdermin E dictates inflammatory responses by controlling the mode of neutrophil death. Nat Commun. 2024 Jan 09; 15(1):386.Nat Commun2024-01-09T00:00:002024Gasdermin E dictates inflammatory responses by controlling the mode of neutrophil death.true1Professor of Stem Cell and Regenerative BiologyProfessor of Stem Cell and Regenerative Biologytrue1Professor of Pathology, EmeritusProfessor of Pathology, Emeritustrue1Principal Associate in PathologyPrincipal Associate in Pathologytrue1Associate Professor of PathologyAssociate Professor of Pathologytrue1Professor of PathologyProfessor of Pathologytrue1Instructor in PathologyInstructor in Pathologytrue1Research Fellow in PathologyResearch Fellow in Pathologytrue1Research Fellow in PathologyResearch Fellow in Pathologytrue1Associate Professor of Psychology in the Department of PsychiatryAssociate Professor of Psychology in the Department of Psychiatrytrue1James L. Gamble Professor of PediatricsJames L. Gamble Professor of Pediatricstrue1Professor of Stem Cell and Regenerative BiologyProfessor of Stem Cell and Regenerative BiologyAuthorship 28811311Authorship 3172671Authorship 4055066Authorship 2405855Authorship 3168992Authorship 6472635Authorship 64938110Authorship 65317711Authorship 6508071123838182He K, Qi Q, Chan CB, Xiao G, Liu X, Tucker-Burden C, Wang L, Mao H, Lu X, McDonald FE, Luo H, Fan QW, Weiss WA, Sun SY, Brat DJ, Ye KScience signalingBlockade of glioma proliferation through allosteric inhibition of JAK2. Sci Signal. 2013 Jul 09; 6(283):ra55.Sci Signal2013-07-09T00:00:002013Blockade of glioma proliferation through allosteric inhibition of JAK2.23445871Liu X, Qi Q, Xiao G, Li J, Luo HR, Ye KPharmacologyO-methylated metabolite of 7,8-dihydroxyflavone activates TrkB receptor and displays antidepressant activity. Pharmacology. 2013; 91(3-4):185-200.Pharmacology2013-02-21T00:00:002013O-methylated metabolite of 7,8-dihydroxyflavone activates TrkB receptor and displays antidepressant activity.23610437Xu Y, Li H, Bajrami B, Kwak H, Cao S, Liu P, Zhou J, Zhou Y, Zhu H, Ye K, Luo HRProceedings of the National Academy of Sciences of the United States of AmericaCigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):7726-31.Proc Natl Acad Sci U S A2013-04-22T00:00:002013Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate.Authorship 2046843Authorship 2057261Authorship 7030201024291762Wang X, Robertson AL, Li J, Chai RJ, Haishan W, Sadiku P, Ogryzko NV, Everett M, Yoganathan K, Luo HR, Renshaw SA, Ingham PWDisease models & mechanismsInhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library. Dis Model Mech. 2014 Jan; 7(1):163-9.Dis Model Mech2013-11-28T00:00:002013Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library.Authorship 23692414Authorship 39913416Authorship 71072711Authorship 713849121073191Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, Phun LH, France S, Xiao G, Jia Y, Luo HR, Ye KJournal of medicinal chemistryA synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. J Med Chem. 2010 Dec 09; 53(23):8274-86.J Med Chem2010-11-12T00:00:002010A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect.24677403Luo HRBloodA dual regulator of neutrophil recruitment. Blood. 2014 Mar 27; 123(13):1983-5.Blood2014-03-27T00:00:002014A dual regulator of neutrophil recruitment.Authorship 2741341Authorship 7280561324634219Ma L, Gong H, Zhu H, Ji Q, Su P, Liu P, Cao S, Yao J, Jiang L, Han M, Ma X, Xiong D, Luo HR, Wang F, Zhou J, Xu YThe Journal of biological chemistryA novel small-molecule tumor necrosis factor a inhibitor attenuates inflammation in a hepatitis mouse model. J Biol Chem. 2014 May 02; 289(18):12457-66.J Biol Chem2014-03-14T00:00:002014A novel small-molecule tumor necrosis factor a inhibitor attenuates inflammation in a hepatitis mouse model.Authorship 732538324726838Jo H, Loison F, Luo HRCellular signallingMicrotubule dynamics regulates Akt signaling via dynactin p150. Cell Signal. 2014 Aug; 26(8):1707-16.Cell Signal2014-04-12T00:00:002014Microtubule dynamics regulates Akt signaling via dynactin p150.Authorship 4034112Authorship 7595601325180606Loison F, Zhu H, Karatepe K, Kasorn A, Liu P, Ye K, Zhou J, Cao S, Gong H, Jenne DE, Remold-O'Donnell E, Xu Y, Luo HRThe Journal of clinical investigationProteinase 3-dependent caspase-3 cleavage modulates neutrophil death and inflammation. J Clin Invest. 2014 Oct; 124(10):4445-58.J Clin Invest2014-09-02T00:00:002014Proteinase 3-dependent caspase-3 cleavage modulates neutrophil death and inflammation.Authorship 775735925398017Zhao F, Li J, Zhou N, Sakai J, Gao Y, Shi J, Goldman B, Browdy HM, Luo HR, Xu BBioconjugate chemistryDe novo chemoattractants form supramolecular hydrogels for immunomodulating neutrophils in vivo. Bioconjug Chem. 2014 Dec 17; 25(12):2116-22.Bioconjug Chem2014-11-25T00:00:002014De novo chemoattractants form supramolecular hydrogels for immunomodulating neutrophils in vivo.Authorship 73771325735562Kaunisto A, Henry WS, Montaser-Kouhsari L, Jaminet SC, Oh EY, Zhao L, Luo HR, Beck AH, Toker AMolecular oncologyNFAT1 promotes intratumoral neutrophil infiltration by regulating IL8 expression in breast cancer. Mol Oncol. 2015 Jun; 9(6):1140-54.Mol Oncol2015-02-19T00:00:002015NFAT1 promotes intratumoral neutrophil infiltration by regulating IL8 expression in breast cancer.Authorship 895185Authorship 4894188Authorship 47733311Authorship 3063368Authorship 1832337Authorship 18782610Authorship 676455Authorship 773027Authorship 414709Authorship 2061295Authorship 2631483Authorship 3962067Authorship 417944Authorship 4076646Authorship 5549322Authorship 7996041Authorship 80231813Authorship 7897837Authorship 791200325579427Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C, Mondal S, Sun Y, Zhu H, Chai L, Silberstein LE, Cheng T, Luo HRImmunityMyeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis. Immunity. 2015 Jan 20; 42(1):159-71.Immunity2015-01-08T00:00:002015Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis.25576302Luo HR, Mondal SEMBO reportsMolecular control of PtdIns(3,4,5)P3 signaling in neutrophils. EMBO Rep. 2015 Feb; 16(2):149-63.EMBO Rep2015-01-09T00:00:002015Molecular control of PtdIns(3,4,5)P3 signaling in neutrophils.26039999Qi Q, Li DY, Luo HR, Guan KL, Ye KProceedings of the National Academy of Sciences of the United States of AmericaNetrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability. Proc Natl Acad Sci U S A. 2015 Jun 09; 112(23):7255-60.Proc Natl Acad Sci U S A2015-05-26T00:00:002015Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability.Authorship 2459903Authorship 28732412Authorship 2996975Authorship 34251911Associate Professor6Fellow or Post Doc0Full Professor4Instructor5Other FacultyAuthorship 56923614Authorship 527152527551153Bajrami B, Zhu H, Kwak HJ, Mondal S, Hou Q, Geng G, Karatepe K, Zhang YC, Nombela-Arrieta C, Park SY, Loison F, Sakai J, Xu Y, Silberstein LE, Luo HRThe Journal of experimental medicineG-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling. J Exp Med. 2016 09 19; 213(10):1999-2018.J Exp Med2016-08-22T00:00:002016G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling.Authorship 568078132021-03-31SILBERSTEIN, LESLIE ERIC2009-04-01Molecular Mechanisms of Blood Cell TransfusionP01HL0954892011-08-31LUO, HONGBO R2007-04-01Molecular basis of neutrophil spontaneous deathR01HL0851002011-09-30LUO, HONGBO R2006-08-01Signal transduction in neutrophil chemotaxisR01GM0760842013-07-31LUO, HONGBO R2009-02-06HTS for enhancers of neutrophil function that specifically augment PIP3 signalR01AI0764712007-08-31LUO, HONGBO R2006-09-20High throughput screening for inhibitors of Akt plasma mR03NS0537562024-04-30LUO, HONGBO R2008-04-01Enhancing neutrophil function in neutropenia-related pneumoniaR01HL0920202020-02-29LUO, HONGBO R2014-03-01Regulation of neutrophil function by ROS-induced actin glutathionylationR01AI1031422007-05-31LUO, HONGBO R2005-07-15InsP7 in glutamate excitotoxicityR21NS052200Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorAuthorship 91664615Authorship 4090108Authorship 3593559Authorship 4301026Authorship 47275010Authorship 963647326029732Loison F, Xu Y, Luo HRInflammation and cell signalingProteinase 3 and Serpin B1: a novel pathway in the regulation of caspase-3 activation, neutrophil spontaneous apoptosis, and inflammation. Inflamm Cell Signal. 2014; 1(6).Inflamm Cell Signal2014-01-01T00:00:002014Proteinase 3 and Serpin B1: a novel pathway in the regulation of caspase-3 activation, neutrophil spontaneous apoptosis, and inflammation.Authorship 9668621428235862Zhu H, Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C, Mondal S, Kambara H, Yu H, Chai L, Silberstein LE, Cheng T, Luo HRJournal of immunology (Baltimore, Md. : 1950)Reactive Oxygen Species-Producing Myeloid Cells Act as a Bone Marrow Niche for Sterile Inflammation-Induced Reactive Granulopoiesis. J Immunol. 2017 04 01; 198(7):2854-2864.J Immunol2017-02-24T00:00:002017Reactive Oxygen Species-Producing Myeloid Cells Act as a Bone Marrow Niche for Sterile Inflammation-Induced Reactive Granulopoiesis.13678580Luo HR, Huang YE, Chen JC, Saiardi A, Iijima M, Ye K, Huang Y, Nagata E, Devreotes P, Snyder SHCellInositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Cell. 2003 Sep 05; 114(5):559-72.Cell2003-09-05T00:00:002003Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions.Authorship 979559228437875Teng Y, Luo HR, Kambara HAmerican journal of hematologyHeterogeneity of neutrophil spontaneous death. Am J Hematol. 2017 08; 92(8):E156-E159.Am J Hematol2017-06-09T00:00:002017Heterogeneity of neutrophil spontaneous death.22043008Mondal S, Ghosh-Roy S, Loison F, Li Y, Jia Y, Harris C, Williams DA, Luo HRJournal of immunology (Baltimore, Md. : 1950)PTEN negatively regulates engulfment of apoptotic cells by modulating activation of Rac GTPase. J Immunol. 2011 Dec 01; 187(11):5783-94.J Immunol2011-10-31T00:00:002011PTEN negatively regulates engulfment of apoptotic cells by modulating activation of Rac GTPase.11823862Ye K, Aghdasi B, Luo HR, Moriarity JL, Wu FY, Hong JJ, Hurt KJ, Bae SS, Suh PG, Snyder SHNaturePhospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Nature. 2002 Jan 31; 415(6871):541-4.Nature2002-01-31T00:00:002002Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE.18458059Jo H, Jia Y, Subramanian KK, Hattori H, Luo HRMolecular and cellular biologyCancer cell-derived clusterin modulates the phosphatidylinositol 3'-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation. Mol Cell Biol. 2008 Jul; 28(13):4285-99.Mol Cell Biol2008-05-05T00:00:002008Cancer cell-derived clusterin modulates the phosphatidylinositol 3'-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation.19440552Lu J, Jeong HW, Jeong H, Kong N, Yang Y, Carroll J, Luo HR, Silberstein LE, Chai LPloS oneStem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex. PLoS One. 2009; 4(5):e5577.PLoS One2009-05-18T00:00:002009Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex.20413728Carbo C, Duerschmied D, Goerge T, Hattori H, Sakai J, Cifuni SM, White GC, Chrzanowska-Wodnicka M, Luo HR, Wagner DDJournal of leukocyte biologyIntegrin-independent role of CalDAG-GEFI in neutrophil chemotaxis. J Leukoc Biol. 2010 Aug; 88(2):313-9.J Leukoc Biol2010-04-22T00:00:002010Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis.15533939Nagata E, Luo HR, Saiardi A, Bae BI, Suzuki N, Snyder SHThe Journal of biological chemistryInositol hexakisphosphate kinase-2, a physiologic mediator of cell death. J Biol Chem. 2005 Jan 14; 280(2):1634-40.J Biol Chem2004-11-08T00:00:002004Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death.Authorship 9981352428683316Zhang X, Liu P, Zhang C, Chiewchengchol D, Zhao F, Yu H, Li J, Kambara H, Luo KY, Venkataraman A, Zhou Z, Zhou W, Zhu H, Zhao L, Sakai J, Chen Y, Ho YS, Bajrami B, Xu B, Silberstein LE, Cheng T, Xu Y, Ke Y, Luo HRCell reportsPositive Regulation of Interleukin-1ß Bioactivity by Physiological ROS-Mediated Cysteine S-Glutathionylation. Cell Rep. 2017 07 05; 20(1):224-235.Cell Rep2017-07-05T00:00:002017Positive Regulation of Interleukin-1ß Bioactivity by Physiological ROS-Mediated Cysteine S-Glutathionylation.19454716Sarraj B, Massberg S, Li Y, Kasorn A, Subramanian K, Loison F, Silberstein LE, von Andrian U, Luo HRJournal of immunology (Baltimore, Md. : 1950)Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation. J Immunol. 2009 Jun 01; 182(11):7190-200.J Immunol2009-06-01T00:00:002009Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation.21606370Sanchez-Aguilera A, Lee YJ, Lo Celso C, Ferraro F, Brumme K, Mondal S, Kim C, Dorrance A, Luo HR, Scadden DT, Williams DAProceedings of the National Academy of Sciences of the United States of AmericaGuanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells. Proc Natl Acad Sci U S A. 2011 Jun 07; 108(23):9607-12.Proc Natl Acad Sci U S A2011-05-23T00:00:002011Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells.22155722Lu J, Sun Y, Nombela-Arrieta C, Du KP, Park SY, Chai L, Walkley C, Luo HR, Silberstein LEExperimental hematologyFak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion. Exp Hematol. 2012 Apr; 40(4):307-17.e3.Exp Hematol2011-12-08T00:00:002011Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion.20714413Hattori H, Subramanian KK, Sakai J, Luo HRCommunicative & integrative biologyReactive oxygen species as signaling molecules in neutrophil chemotaxis. Commun Integr Biol. 2010 May; 3(3):278-81.Commun Integr Biol2010-05-01T00:00:002010Reactive oxygen species as signaling molecules in neutrophil chemotaxis.21685907Prasad A, Jia Y, Chakraborty A, Li Y, Jain SK, Zhong J, Roy SG, Loison F, Mondal S, Sakai J, Blanchard C, Snyder SH, Luo HRNature immunologyInositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling. Nat Immunol. 2011 Jun 19; 12(8):752-60.Nat Immunol2011-06-19T00:00:002011Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling.18339802Jia Y, Loison F, Hattori H, Li Y, Erneux C, Park SY, Gao C, Chai L, Silberstein LE, Schurmans S, Luo HRProceedings of the National Academy of Sciences of the United States of AmericaInositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4739-44.Proc Natl Acad Sci U S A2008-03-13T00:00:002008Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis.20363972Simarro M, Giannattasio G, De la Fuente MA, Benarafa C, Subramanian KK, Ishizawar R, Balestrieri B, Andersson EM, Luo HR, Orduña A, Boyce J, Anderson PJournal of immunology (Baltimore, Md. : 1950)Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation. J Immunol. 2010 May 01; 184(9):5325-32.J Immunol2010-04-02T00:00:002010Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation.21521784Li Y, Prasad A, Jia Y, Roy SG, Loison F, Mondal S, Kocjan P, Silberstein LE, Ding S, Luo HRBloodPretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood. 2011 Jun 16; 117(24):6702-13.Blood2011-04-26T00:00:002011Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model.1 Blackfan CircleChildren's HospitalKarp Family Research Bldg., 10th Fl., Rm 102141 Blackfan CircleBoston02115MA11851397Luo HR, Saiardi A, Yu H, Nagata E, Ye K, Snyder SHBiochemistryInositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeast. Biochemistry. 2002 Feb 26; 41(8):2509-15.Biochemistry2002-02-26T00:00:002002Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeast.20133633Xu Y, Loison F, Luo HRProceedings of the National Academy of Sciences of the United States of AmericaNeutrophil spontaneous death is mediated by down-regulation of autocrine signaling through GPCR, PI3Kgamma, ROS, and actin. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):2950-5.Proc Natl Acad Sci U S A2010-02-01T00:00:002010Neutrophil spontaneous death is mediated by down-regulation of autocrine signaling through GPCR, PI3Kgamma, ROS, and actin.14764604Iijima M, Huang YE, Luo HR, Vazquez F, Devreotes PNThe Journal of biological chemistryNovel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. J Biol Chem. 2004 Apr 16; 279(16):16606-13.J Biol Chem2004-02-05T00:00:002004Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis.23063331Oyoshi MK, He R, Li Y, Mondal S, Yoon J, Afshar R, Chen M, Lee DM, Luo HR, Luster AD, Cho JS, Miller LS, Larson A, Murphy GF, Geha RSImmunityLeukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity. 2012 Oct 19; 37(4):747-58.Immunity2012-10-11T00:00:002012Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation.17825589Jia Y, Subramanian KK, Erneux C, Pouillon V, Hattori H, Jo H, You J, Zhu D, Schurmans S, Luo HRImmunityInositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils. Immunity. 2007 Sep; 27(3):453-67.Immunity2007-09-06T00:00:002007Inositol 1,3,4,5-tetrakisphosphate negatively regulates phosphatidylinositol-3,4,5- trisphosphate signaling in neutrophils.Authorship 10335881026972179Damnernsawad A, Kong G, Wen Z, Liu Y, Rajagopalan A, You X, Wang J, Zhou Y, Ranheim EA, Luo HR, Chang Q, Zhang JStem cells (Dayton, Ohio)Kras is Required for Adult Hematopoiesis. Stem Cells. 2016 07; 34(7):1859-71.Stem Cells2016-03-28T00:00:002016Kras is Required for Adult Hematopoiesis.20428237Jo H, Loison F, Hattori H, Silberstein LE, Yu H, Luo HRPloS oneNatural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs. PLoS One. 2010 Apr 23; 5(4):e10318.PLoS One2010-04-23T00:00:002010Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs.22365599Jo H, Luo HRChemistry & biologyExploiting effectors of Rac GTPase. Chem Biol. 2012 Feb 24; 19(2):169-71.Chem Biol2012-02-24T00:00:002012Exploiting effectors of Rac GTPase.23159440Sakai J, Li J, Subramanian KK, Mondal S, Bajrami B, Hattori H, Jia Y, Dickinson BC, Zhong J, Ye K, Chang CJ, Ho YS, Zhou J, Luo HRImmunityReactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils. Immunity. 2012 Dec 14; 37(6):1037-49.Immunity2012-11-15T00:00:002012Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils.20068140Chan CB, Liu X, Jung DY, Jun JY, Luo HR, Kim JK, Ye KDiabetesDeficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance. Diabetes. 2010 Apr; 59(4):883-93.Diabetes2010-01-12T00:00:002010Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance.22388960Wu LJ, Wu G, Akhavan Sharif MR, Baker A, Jia Y, Fahey FH, Luo HR, Feener EP, Clapham DENature neuroscienceThe voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nat Neurosci. 2012 Mar 04; 15(4):565-73.Nat Neurosci2012-03-04T00:00:002012The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke.15944123Huang Y, Man HY, Sekine-Aizawa Y, Han Y, Juluri K, Luo H, Cheah J, Lowenstein C, Huganir RL, Snyder SHNeuronS-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors. Neuron. 2005 May 19; 46(4):533-40.Neuron2005-05-19T00:00:002005S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors.