Gledhill RF, Bartel PR, Yoshida Y, Nishino S, Scammell TE
Narcolepsy caused by acute disseminated encephalomyelitis. Arch Neurol. 2004 May; 61(5):758-60.
Narcolepsy caused by acute disseminated encephalomyelitis.
Wakefulness: an eye-opening perspective on orexin neurons. Curr Biol. 2001 Oct 02; 11(19):R769-71.
Wakefulness: an eye-opening perspective on orexin neurons.
Orexin/Hypocretin: wired for wakefulness. Curr Biol. 2003 Jul 15; 13(14):R563-4.
Orexin/Hypocretin: wired for wakefulness.
Llewellyn-Smith IJ, Martin CL, Marcus JN, Yanagisawa M, Minson JB, Scammell TE
Orexin-immunoreactive inputs to rat sympathetic preganglionic neurons. Neurosci Lett. 2003 Nov 13; 351(2):115-9.
Orexin-immunoreactive inputs to rat sympathetic preganglionic neurons.
Hypothalamic regulation of sleep and circadian rhythms. Nature. 2005 Oct 27; 437(7063):1257-63.
Hypothalamic regulation of sleep and circadian rhythms.
Dimitrova A, Fronczek R, Van der Ploeg J, Scammell T, Gautam S, Pascual-Leone A, Lammers GJ
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
Reward-seeking behavior in human narcolepsy. J Clin Sleep Med. 2011 Jun 15; 7(3):293-300.
Reward-seeking behavior in human narcolepsy.
Hypocretin/orexin and sleep: implications for the pathophysiology and diagnosis of narcolepsy. Curr Opin Neurol. 2002 Dec; 15(6):739-45.
Hypocretin/orexin and sleep: implications for the pathophysiology and diagnosis of narcolepsy.
Kramer A, Yang FC, Snodgrass P, Li X, Scammell TE, Davis FC, Weitz CJ
Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signalling. Novartis Found Symp. 2003; 253:250-62; discussion 102-9, 263-6, 281-4.
Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signalling.
Mochizuki T, Arrigoni E, Marcus JN, Clark EL, Yamamoto M, Honer M, Borroni E, Lowell BB, Elmquist JK, Scammell TE
Proceedings of the National Academy of Sciences of the United States of America
Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4471-6.
Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice.
Modafinil: a novel stimulant for the treatment of narcolepsy. Expert Opin Investig Drugs. 1998 Jan; 7(1):99-112.
Modafinil: a novel stimulant for the treatment of narcolepsy.
Behn CG, Brown EN, Scammell TE, Kopell NJ
Mathematical model of network dynamics governing mouse sleep-wake behavior. J Neurophysiol. 2007 Jun; 97(6):3828-40.
Mathematical model of network dynamics governing mouse sleep-wake behavior.
Lövblad KO, Thomas R, Jakob PM, Scammell T, Bassetti C, Griswold M, Ives J, Matheson J, Edelman RR, Warach S
Silent functional magnetic resonance imaging demonstrates focal activation in rapid eye movement sleep. Neurology. 1999 Dec 10; 53(9):2193-5.
Silent functional magnetic resonance imaging demonstrates focal activation in rapid eye movement sleep.
Pharmacotherapy for cataplexy. Sleep Med Rev. 2004 Oct; 8(5):355-66.
Willie JT, Renthal W, Chemelli RM, Miller MS, Scammell TE, Yanagisawa M, Sinton CM
Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates. Neuroscience. 2005; 130(4):983-95.
Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates.
Activation of the basal forebrain by the orexin/hypocretin neurones. Acta Physiol (Oxf). 2010 Mar; 198(3):223-35.
Activation of the basal forebrain by the orexin/hypocretin neurones.
Is low histamine a fundamental cause of sleepiness in narcolepsy and idiopathic hypersomnia? Sleep. 2009 Feb; 32(2):133-4.
Is low histamine a fundamental cause of sleepiness in narcolepsy and idiopathic hypersomnia?
Scott MM, Marcus JN, Pettersen A, Birnbaum SG, Mochizuki T, Scammell TE, Nestler EJ, Elmquist JK, Lutter M
Hcrtr1 and 2 signaling differentially regulates depression-like behaviors. Behav Brain Res. 2011 Sep 23; 222(2):289-94.
Hcrtr1 and 2 signaling differentially regulates depression-like behaviors.
Naganuma F, Bandaru SS, Absi G, Mahoney CE, Scammell TE, Vetrivelan R
Melanin-concentrating hormone neurons contribute to dysregulation of rapid eye movement sleep in narcolepsy. Neurobiol Dis. 2018 12; 120:12-20.
Melanin-concentrating hormone neurons contribute to dysregulation of rapid eye movement sleep in narcolepsy.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Narcolepsy: neural mechanisms of sleepiness and cataplexy. J Neurosci. 2012 Sep 05; 32(36):12305-11.
Narcolepsy: neural mechanisms of sleepiness and cataplexy.
Diniz Behn CG, Kopell N, Brown EN, Mochizuki T, Scammell TE
Delayed orexin signaling consolidates wakefulness and sleep: physiology and modeling. J Neurophysiol. 2008 Jun; 99(6):3090-103.
Delayed orexin signaling consolidates wakefulness and sleep: physiology and modeling.
Scammell TE, Jackson AC, Franks NP, Wisden W, Dauvilliers Y
Histamine: neural circuits and new medications. Sleep. 2019 01 01; 42(1).
Histamine: neural circuits and new medications.
Scammell TE, Matheson JK, Honda M, Thannickal TC, Siegel JM
Coexistence of narcolepsy and Alzheimer's disease. Neurobiol Aging. 2012 Jul; 33(7):1318-9.
Coexistence of narcolepsy and Alzheimer's disease.
Kroeger D, Absi G, Gagliardi C, Bandaru SS, Madara JC, Ferrari LL, Arrigoni E, Münzberg H, Scammell TE, Saper CB, Vetrivelan R
Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice. Nat Commun. 2018 10 08; 9(1):4129.
Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice.
Sleep neurobiology for the clinician. Sleep. 2004 Jun 15; 27(4):811-20.
Anderson MP, Mochizuki T, Xie J, Fischler W, Manger JP, Talley EM, Scammell TE, Tonegawa S
Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1743-8.
Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep.
No evidence for a circadian rhythm of protein synthesis in the rat suprachiasmatic nuclei. Brain Res. 1989 Aug 07; 494(1):155-8.
No evidence for a circadian rhythm of protein synthesis in the rat suprachiasmatic nuclei.
Mahoney CE, Cogswell A, Koralnik IJ, Scammell TE
The neurobiological basis of narcolepsy. Nat Rev Neurosci. 2019 02; 20(2):83-93.
The neurobiological basis of narcolepsy.
The neurobiology, diagnosis, and treatment of narcolepsy. Ann Neurol. 2003 Feb; 53(2):154-66.
The neurobiology, diagnosis, and treatment of narcolepsy.
Agostinelli LJ, Geerling JC, Scammell TE
Basal forebrain subcortical projections. Brain Struct Funct. 2019 Apr; 224(3):1097-1117.
Basal forebrain subcortical projections.
The trouble with Tribbles: do antibodies against TRIB2 cause narcolepsy? Sleep. 2010 Jul; 33(7):857-8.
The trouble with Tribbles: do antibodies against TRIB2 cause narcolepsy?
Saper CB, Fuller PM, Pedersen NP, Lu J, Scammell TE
Sleep state switching. Neuron. 2010 Dec 22; 68(6):1023-42.
McAlpine CS, Kiss MG, Rattik S, He S, Vassalli A, Valet C, Anzai A, Chan CT, Mindur JE, Kahles F, Poller WC, Frodermann V, Fenn AM, Gregory AF, Halle L, Iwamoto Y, Hoyer FF, Binder CJ, Libby P, Tafti M, Scammell TE, Nahrendorf M, Swirski FK
Sleep modulates haematopoiesis and protects against atherosclerosis. Nature. 2019 02; 566(7744):383-387.
Sleep modulates haematopoiesis and protects against atherosclerosis.
Intracellular Signaling Peptides and Proteins
James Jackson Putnam Professor of Neurology
Frank Baldino, Jr., Ph.D. Professor of Sleep Medicine
Peter C. Farrell Professor of Sleep Medicine
Bassetti CLA, Adamantidis A, Burdakov D, Han F, Gay S, Kallweit U, Khatami R, Koning F, Kornum BR, Lammers GJ, Liblau RS, Luppi PH, Mayer G, Pollmächer T, Sakurai T, Sallusto F, Scammell TE, Tafti M, Dauvilliers Y
Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment. Nat Rev Neurol. 2019 09; 15(9):519-539.
Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment.
Gisabella B, Scammell T, Bandaru SS, Saper CB
Regulation of hippocampal dendritic spines following sleep deprivation. J Comp Neurol. 2020 02 15; 528(3):380-388.
Regulation of hippocampal dendritic spines following sleep deprivation.
Venner A, Mochizuki T, De Luca R, Anaclet C, Scammell TE, Saper CB, Arrigoni E, Fuller PM
Reassessing the Role of Histaminergic Tuberomammillary Neurons in Arousal Control. J Neurosci. 2019 11 06; 39(45):8929-8939.
Reassessing the Role of Histaminergic Tuberomammillary Neurons in Arousal Control.
Lombardi F, Gómez-Extremera M, Bernaola-Galván P, Vetrivelan R, Saper CB, Scammell TE, Ivanov PC
Critical Dynamics and Coupling in Bursts of Cortical Rhythms Indicate Non-Homeostatic Mechanism for Sleep-Stage Transitions and Dual Role of VLPO Neurons in Both Sleep and Wake. J Neurosci. 2020 01 02; 40(1):171-190.
Critical Dynamics and Coupling in Bursts of Cortical Rhythms Indicate Non-Homeostatic Mechanism for Sleep-Stage Transitions and Dual Role of VLPO Neurons in Both Sleep and Wake.
Cogswell AC, Maski K, Scammell TE, Tucker D, Orban ZS, Koralnik IJ
Annals of clinical and translational neurology
Children with Narcolepsy type 1 have increased T-cell responses to orexins. Ann Clin Transl Neurol. 2019 12; 6(12):2566-2572.
Children with Narcolepsy type 1 have increased T-cell responses to orexins.
Dual orexin receptor antagonists increase sleep and cataplexy in wild type mice. Sleep. 2020 06 15; 43(6).
Dual orexin receptor antagonists increase sleep and cataplexy in wild type mice.
Adamantidis AR, Schmidt MH, Carter ME, Burdakov D, Peyron C, Scammell TE
A circuit perspective on narcolepsy. Sleep. 2020 05 12; 43(5).
Scammell TE, Luo G, Borker P, Sullivan L, Biddle K, Mignot E
Treatment of narcolepsy with natalizumab. Sleep. 2020 07 13; 43(7).
Treatment of narcolepsy with natalizumab.
Maski K, Pizza F, Liu S, Steinhart E, Little E, Colclasure A, Diniz Behn C, Vandi S, Antelmi E, Weller E, Scammell TE, Plazzi G
Defining disrupted nighttime sleep and assessing its diagnostic utility for pediatric narcolepsy type 1. Sleep. 2020 10 13; 43(10).
Defining disrupted nighttime sleep and assessing its diagnostic utility for pediatric narcolepsy type 1.
Univ. of Mass. Medical Center, Medicine Resident
Univ. of California, Neurology Residency
Center for Stress and Neural Regulation of Reproductive Aging Health Outcomes
COMMENTARY on Lammers et al, Diagnosis of central disorders of hypersomnolence: Challenges in defining central disorders of hypersomnolence. Sleep Med Rev. 2020 08; 52:101327.
COMMENTARY on Lammers et al, Diagnosis of central disorders of hypersomnolence: Challenges in defining central disorders of hypersomnolence.
Agostinelli LJ, Mix MR, Hefti MM, Scammell TE, Bassuk AG
Input-output connections of LJA5 prodynorphin neurons. J Comp Neurol. 2021 02; 529(3):635-654.
Input-output connections of LJA5 prodynorphin neurons.
Maski KP, Colclasure A, Little E, Steinhart E, Scammell TE, Navidi W, Diniz Behn C
Stability of nocturnal wake and sleep stages defines central nervous system disorders of hypersomnolence. Sleep. 2021 07 09; 44(7).
Stability of nocturnal wake and sleep stages defines central nervous system disorders of hypersomnolence.
Coffey AA, Joyal AA, Yamanaka A, Scammell TE
The Impacts of Age and Sex in a Mouse Model of Childhood Narcolepsy. Front Neurosci. 2021; 15:644757.
The Impacts of Age and Sex in a Mouse Model of Childhood Narcolepsy.
Xiao X, Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan DA, Wunderlich FT, Rahmouni K, Kong D, Scammell TE, Lowell BB, Kloppenburg P, Brüning JC, Hausen AC
Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. Nat Commun. 2021 09 02; 12(1):5249.
Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity.
Maski K, Worhach J, Steinhart E, Boduch M, Morse AM, Strunc M, Scammell T, Owens J, Jesteadt L, Crisp C, Williams D, Sideridis G
Development and Validation of the Pediatric Hypersomnolence Survey. Neurology. 2022 05 10; 98(19):e1964-e1975.
Development and Validation of the Pediatric Hypersomnolence Survey.
Narcolepsy is a common sleep disorder caused by loss of the orexin-producing neurons in the hypothalamus. The student will perform basic science research using mouse models of narcolepsy to identify the brain circuits that give rise to sleepiness and cataplexy. Techniques may include fiber photometry to track neuronal activity and levels of neurotransmitters, optogenetics, chemogenetics, sleep recordings in mice, and anatomic studies. Prior experience in basic animal research is helpful but not necessary. The mentor (Dr. Scammell) has an office next to the lab in the Center for Life Sciences and will meet with the student at least weekly.
Shi SQ, Mahoney CE, Houdek P, Zhao W, Anderson MP, Zhuo X, Beaudet A, Sumova A, Scammell TE, Johnson CH
Circadian Rhythms and Sleep Are Dependent Upon Expression Levels of Key Ubiquitin Ligase Ube3a. Front Behav Neurosci. 2022; 16:837523.
Circadian Rhythms and Sleep Are Dependent Upon Expression Levels of Key Ubiquitin Ligase Ube3a.
De Luca R, Nardone S, Grace KP, Venner A, Cristofolini M, Bandaru SS, Sohn LT, Kong D, Mochizuki T, Viberti B, Zhu L, Zito A, Scammell TE, Saper CB, Lowell BB, Fuller PM, Arrigoni E
Orexin neurons inhibit sleep to promote arousal. Nat Commun. 2022 07 18; 13(1):4163.
Orexin neurons inhibit sleep to promote arousal.
Major advances in sleep neurology: 2002-22. Lancet Neurol. 2022 08; 21(8):678-680.
Major advances in sleep neurology: 2002-22.
Kroeger D, Thundercliffe J, Phung A, De Luca R, Geraci C, Bragg S, McCafferty KJ, Bandaru SS, Arrigoni E, Scammell TE
Glutamatergic pedunculopontine tegmental neurons control wakefulness and locomotion via distinct axonal projections. Sleep. 2022 Dec 12; 45(12).
Glutamatergic pedunculopontine tegmental neurons control wakefulness and locomotion via distinct axonal projections.
Davidson RD, Biddle K, Nassan M, Scammell TE, Zhou ES
The impact of narcolepsy on social relationships in young adults. J Clin Sleep Med. 2022 12 01; 18(12):2751-2761.
The impact of narcolepsy on social relationships in young adults.
Dauvilliers Y, Bogan RK, Arnulf I, Scammell TE, St Louis EK, Thorpy MJ
Clinical considerations for the diagnosis of idiopathic hypersomnia. Sleep Med Rev. 2022 12; 66:101709.
Clinical considerations for the diagnosis of idiopathic hypersomnia.
Di Marco T, Scammell TE, Meinel M, Seboek Kinter D, Datta AN, Zammit G, Dauvilliers Y
Number, Duration, and Distribution of Wake Bouts in Patients with Insomnia Disorder: Effect of Daridorexant and Zolpidem. CNS Drugs. 2023 07; 37(7):639-653.
Number, Duration, and Distribution of Wake Bouts in Patients with Insomnia Disorder: Effect of Daridorexant and Zolpidem.
Dauvilliers Y, Mignot E, Del Río Villegas R, Du Y, Hanson E, Inoue Y, Kadali H, Koundourakis E, Meyer S, Rogers R, Scammell TE, Sheikh SI, Swick T, Szakács Z, von Rosenstiel P, Wu J, Zeitz H, Murthy NV, Plazzi G, von Hehn C
Oral Orexin Receptor 2 Agonist in Narcolepsy Type 1. N Engl J Med. 2023 07 27; 389(4):309-321.
Oral Orexin Receptor 2 Agonist in Narcolepsy Type 1.
Harriet Tubman's Hypersomnia: Insights from Historical and Medical Perspectives. J Gen Intern Med. 2023 12; 38(16):3621-3627.
Harriet Tubman's Hypersomnia: Insights from Historical and Medical Perspectives.
What is cataplexy? Sleep. 2024 Nov 08; 47(11).
Korkutata M, De Luca R, Fitzgerald B, Arrigoni E, Scammell TE
bioRxiv : the preprint server for biology
Afferent projections to the Calca /CGRP-expressing parabrachial neurons in mice. bioRxiv. 2024 May 08.
Afferent projections to the Calca /CGRP-expressing parabrachial neurons in mice.
Di Marco T, Djonlagic I, Dauvilliers Y, Sadeghi K, Little D, Datta AN, Hubbard J, Hajak G, Krystal A, Olivieri A, Parrino L, Puryear CB, Zammit G, Donoghue J, Scammell TE
Effect of daridorexant on sleep architecture in patients with chronic insomnia disorder: a pooled post hoc analysis of two randomized phase 3 clinical studies. Sleep. 2024 11 08; 47(11).
Effect of daridorexant on sleep architecture in patients with chronic insomnia disorder: a pooled post hoc analysis of two randomized phase 3 clinical studies.
Alexandre C, Miracca G, Holanda VD, Sharma A, Kourbanova K, Ferreira A, Bicca MA, Zeng X, Nassar VA, Lee S, Kaur S, Sarma SV, Sacré P, Scammell TE, Woolf CJ, Latremoliere A
Nociceptor spontaneous activity is responsible for fragmenting non-rapid eye movement sleep in mouse models of neuropathic pain. Sci Transl Med. 2024 04 17; 16(743):eadg3036.
Nociceptor spontaneous activity is responsible for fragmenting non-rapid eye movement sleep in mouse models of neuropathic pain.
Di Marco T, Scammell TE, Sadeghi K, Datta AN, Little D, Tjiptarto N, Djonlagic I, Olivieri A, Zammit G, Krystal A, Pathmanathan J, Donoghue J, Hubbard J, Dauvilliers Y
Hyperarousal features in the sleep architecture of individuals with and without insomnia. J Sleep Res. 2025 02; 34(1):e14256.
Hyperarousal features in the sleep architecture of individuals with and without insomnia.
Impaired cognition in narcolepsy: clinical and neurobiological perspectives. Sleep. 2024 09 09; 47(9).
Impaired cognition in narcolepsy: clinical and neurobiological perspectives.
Harel BT, Gattuso JJ, Latzman RD, Maruff P, Scammell TE, Plazzi G
Sleep advances : a journal of the Sleep Research Society
The nature and magnitude of cognitive impairment in narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia: a meta-analysis. Sleep Adv. 2024; 5(1):zpae043.
The nature and magnitude of cognitive impairment in narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia: a meta-analysis.
Kwon Y, Gami AS, Javaheri S, Pressman GS, Scammell TE, Surkin LA, Zee PC
Journal of the American Heart Association
Cardiovascular Risks in People With Narcolepsy: Expert Panel Consensus Recommendations. J Am Heart Assoc. 2024 Aug 20; 13(16):e035168.
Cardiovascular Risks in People With Narcolepsy: Expert Panel Consensus Recommendations.
Oishi Y, Williams RH, Agostinelli L, Arrigoni E, Fuller PM, Mochizuki T, Saper CB, Scammell TE
Role of the medial prefrontal cortex in cataplexy. J Neurosci. 2013 Jun 05; 33(23):9743-51.
Role of the medial prefrontal cortex in cataplexy.
Burgess CR, Oishi Y, Mochizuki T, Peever JH, Scammell TE
Amygdala lesions reduce cataplexy in orexin knock-out mice. J Neurosci. 2013 Jun 05; 33(23):9734-42.
Amygdala lesions reduce cataplexy in orexin knock-out mice.
Kantor S, Mochizuki T, Lops SN, Ko B, Clain E, Clark E, Yamamoto M, Scammell TE
Orexin gene therapy restores the timing and maintenance of wakefulness in narcoleptic mice. Sleep. 2013 Aug 01; 36(8):1129-38.
Orexin gene therapy restores the timing and maintenance of wakefulness in narcoleptic mice.
Maski K, Heckler G, Worhach J, Mylonas D, Wang G, Szilagyi K, Zhang B, Diniz Behn C, Scammell TE, Stickgold R
Impaired sleep-dependent memory consolidation in pediatric narcolepsy type 1. Sleep. 2025 Feb 10; 48(2).
Impaired sleep-dependent memory consolidation in pediatric narcolepsy type 1.
Heckler G, Worhach J, Wang G, Szilagyi K, Zhang B, Behn CD, Scammell T, Maski K
Characterizing disrupted nighttime sleep and associated functional outcomes in youth with narcolepsy type 1. J Clin Sleep Med. 2025 Feb 01; 21(2):355-363.
Characterizing disrupted nighttime sleep and associated functional outcomes in youth with narcolepsy type 1.
Davidson RD, Blattner M, Scammell TE, Zhou ES
The impact of idiopathic hypersomnia on the social lives of young adults. Sleep Health. 2025 Feb; 11(1):113-119.
The impact of idiopathic hypersomnia on the social lives of young adults.
Korkutata M, De Luca R, Fitzgerald B, Khanday MA, Arrigoni E, Scammell TE
Afferent Projections to the Calca/CGRP-Expressing Parabrachial Neurons in Mice. J Comp Neurol. 2025 Jan; 533(1):e70018.
Afferent Projections to the Calca/CGRP-Expressing Parabrachial Neurons in Mice.
Control of arousal by the orexin neurons. Curr Opin Neurobiol. 2013 Oct; 23(5):752-9.
Control of arousal by the orexin neurons.
Threat of nuclear war. J Fam Pract. 1987 Jan; 24(1):18-20.
Emerging therapeutics in sleep. Ann Neurol. 2013 Sep; 74(3):435-40.
Ishikawa T, Kurimoto E, Joyal AA, Koike T, Kimura H, Scammell TE
An orexin agonist promotes wakefulness and inhibits cataplexy through distinct brain regions. Curr Biol. 2025 May 05; 35(9):2088-2099.e4.
An orexin agonist promotes wakefulness and inhibits cataplexy through distinct brain regions.
Valko PO, Gavrilov YV, Yamamoto M, Reddy H, Haybaeck J, Mignot E, Baumann CR, Scammell TE
Increase of histaminergic tuberomammillary neurons in narcolepsy. Ann Neurol. 2013 Dec; 74(6):794-804.
Increase of histaminergic tuberomammillary neurons in narcolepsy.
Wamsley E, Donjacour CE, Scammell TE, Lammers GJ, Stickgold R
Delusional confusion of dreaming and reality in narcolepsy. Sleep. 2014 Feb 01; 37(2):419-22.
Delusional confusion of dreaming and reality in narcolepsy.
Weng FJ, Williams RH, Hawryluk JM, Lu J, Scammell TE, Saper CB, Arrigoni E
Carbachol excites sublaterodorsal nucleus neurons projecting to the spinal cord. J Physiol. 2014 Apr 01; 592(7):1601-17.
Carbachol excites sublaterodorsal nucleus neurons projecting to the spinal cord.
Williams RH, Chee MJ, Kroeger D, Ferrari LL, Maratos-Flier E, Scammell TE, Arrigoni E
Optogenetic-mediated release of histamine reveals distal and autoregulatory mechanisms for controlling arousal. J Neurosci. 2014 Apr 23; 34(17):6023-9.
Optogenetic-mediated release of histamine reveals distal and autoregulatory mechanisms for controlling arousal.
Baumann CR, Mignot E, Lammers GJ, Overeem S, Arnulf I, Rye D, Dauvilliers Y, Honda M, Owens JA, Plazzi G, Scammell TE
Challenges in diagnosing narcolepsy without cataplexy: a consensus statement. Sleep. 2014 Jun 01; 37(6):1035-42.
Challenges in diagnosing narcolepsy without cataplexy: a consensus statement.
Lammers GJ, Plazzi G, Mignot E, Pizza F, Dauvilliers Y, Barateau L, Maruff P, Scammell TE, Latzman RD, Naylor M, Olsson T, Stukalin E, Tanaka S, Volfson D, Khachadourian V, Harel BT
Effects of Oveporexton, an Orexin Receptor 2-Selective Agonist, on Cognition in Narcolepsy Type 1: A Secondary Analysis of a Randomized Clinical Trial. JAMA Neurol. 2026 Feb 01; 83(2):145-152.
Effects of Oveporexton, an Orexin Receptor 2-Selective Agonist, on Cognition in Narcolepsy Type 1: A Secondary Analysis of a Randomized Clinical Trial.
Bastianini S, Berteotti C, Gabrielli A, Del Vecchio F, Amici R, Alexandre C, Scammell TE, Gazea M, Kimura M, Lo Martire V, Silvani A, Zoccoli G
SCOPRISM: a new algorithm for automatic sleep scoring in mice. J Neurosci Methods. 2014 Sep 30; 235:277-84.
SCOPRISM: a new algorithm for automatic sleep scoring in mice.
Valko PO, Gavrilov YV, Yamamoto M, Finn K, Reddy H, Haybaeck J, Weis S, Scammell TE, Baumann CR
Damage to histaminergic tuberomammillary neurons and other hypothalamic neurons with traumatic brain injury. Ann Neurol. 2015 Jan; 77(1):177-82.
Damage to histaminergic tuberomammillary neurons and other hypothalamic neurons with traumatic brain injury.
Overview of sleep: the neurologic processes of the sleep-wake cycle. J Clin Psychiatry. 2015 May; 76(5):e13.
Overview of sleep: the neurologic processes of the sleep-wake cycle.
Usefulness of a Nocturnal SOREMP for Diagnosing Narcolepsy with Cataplexy in a Pediatric Population. Sleep. 2015 Jun 01; 38(6):859-65.
Usefulness of a Nocturnal SOREMP for Diagnosing Narcolepsy with Cataplexy in a Pediatric Population.
Oishi Y, Yoshida K, Scammell TE, Urade Y, Lazarus M, Saper CB
The roles of prostaglandin E2 and D2 in lipopolysaccharide-mediated changes in sleep. Brain Behav Immun. 2015 Jul; 47:172-7.
The roles of prostaglandin E2 and D2 in lipopolysaccharide-mediated changes in sleep.
Bonsall DR, Kim H, Tocci C, Ndiaye A, Petronzio A, McKay-Corkum G, Molyneux PC, Scammell TE, Harrington ME
Suppression of Locomotor Activity in Female C57Bl/6J Mice Treated with Interleukin-1ß: Investigating a Method for the Study of Fatigue in Laboratory Animals. PLoS One. 2015; 10(10):e0140678.
Suppression of Locomotor Activity in Female C57Bl/6J Mice Treated with Interleukin-1ß: Investigating a Method for the Study of Fatigue in Laboratory Animals.
Perez MV, Pavlovic A, Shang C, Wheeler MT, Miller CL, Liu J, Dewey FE, Pan S, Thanaporn PK, Absher D, Brandimarto J, Salisbury H, Chan K, Mukherjee R, Konadhode RP, Myers RM, Sedehi D, Scammell TE, Quertermous T, Cappola T, Ashley EA
Journal of the American College of Cardiology
Systems Genomics Identifies a Key Role for Hypocretin/Orexin Receptor-2 in Human Heart Failure. J Am Coll Cardiol. 2015 Dec 08; 66(22):2522-33.
Systems Genomics Identifies a Key Role for Hypocretin/Orexin Receptor-2 in Human Heart Failure.
Geerling JC, Kim M, Mahoney CE, Abbott SB, Agostinelli LJ, Garfield AS, Krashes MJ, Lowell BB, Scammell TE
American journal of physiology. Regulatory, integrative and comparative physiology
Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleus. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 01; 310(1):R41-54.
Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleus.
Ferrari LL, Agostinelli LJ, Krashes MJ, Lowell BB, Scammell TE, Arrigoni E
Dynorphin inhibits basal forebrain cholinergic neurons by pre- and postsynaptic mechanisms. J Physiol. 2016 Feb 15; 594(4):1069-85.
Dynorphin inhibits basal forebrain cholinergic neurons by pre- and postsynaptic mechanisms.
Branch AF, Navidi W, Tabuchi S, Terao A, Yamanaka A, Scammell TE, Diniz Behn C
Progressive Loss of the Orexin Neurons Reveals Dual Effects on Wakefulness. Sleep. 2016 Feb 01; 39(2):369-77.
Progressive Loss of the Orexin Neurons Reveals Dual Effects on Wakefulness.
Imbach LL, Sommerauer M, Poryazova R, Werth E, Valko PO, Scammell TE, Baumann CR
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Bradysomnia in Parkinson's disease. Clin Neurophysiol. 2016 Feb; 127(2):1403-1409.
Circadian Rhythms in Mice with Genetic Ablation of the Orexin Neurons
Gavrilov YV, Ellison BA, Yamamoto M, Reddy H, Haybaeck J, Mignot E, Baumann CR, Scammell TE, Valko PO
Disrupted Sleep in Narcolepsy: Exploring the Integrity of Galanin Neurons in the Ventrolateral Preoptic Area. Sleep. 2016 05 01; 39(5):1059-62.
Disrupted Sleep in Narcolepsy: Exploring the Integrity of Galanin Neurons in the Ventrolateral Preoptic Area.
Valko PO, Gavrilov YV, Yamamoto M, Noaín D, Reddy H, Haybaeck J, Weis S, Baumann CR, Scammell TE
Damage to Arousal-Promoting Brainstem Neurons with Traumatic Brain Injury. Sleep. 2016 06 01; 39(6):1249-52.
Damage to Arousal-Promoting Brainstem Neurons with Traumatic Brain Injury.
Harvard Center on Sleep Neurobiology and Sleep Apnea (SCOR)
ADENOSINE AND THE PREOPTIC REGULATION OF SLEEP
Circadian and Aminergic Regulation of Orexin Neurons
Garfield AS, Shah BP, Burgess CR, Li MM, Li C, Steger JS, Madara JC, Campbell JN, Kroeger D, Scammell TE, Tannous BA, Myers MG, Andermann ML, Krashes MJ, Lowell BB
Dynamic GABAergic afferent modulation of AgRP neurons. Nat Neurosci. 2016 12; 19(12):1628-1635.
Dynamic GABAergic afferent modulation of AgRP neurons.
Maski K, Steinhart E, Williams D, Scammell T, Flygare J, McCleary K, Gow M
Listening to the Patient Voice in Narcolepsy: Diagnostic Delay, Disease Burden, and Treatment Efficacy. J Clin Sleep Med. 2017 Mar 15; 13(3):419-425.
Listening to the Patient Voice in Narcolepsy: Diagnostic Delay, Disease Burden, and Treatment Efficacy.
Agostinelli LJ, Ferrari LL, Mahoney CE, Mochizuki T, Lowell BB, Arrigoni E, Scammell TE
Descending projections from the basal forebrain to the orexin neurons in mice. J Comp Neurol. 2017 May 01; 525(7):1668-1684.
Descending projections from the basal forebrain to the orexin neurons in mice.
Kroeger D, Ferrari LL, Petit G, Mahoney CE, Fuller PM, Arrigoni E, Scammell TE
Cholinergic, Glutamatergic, and GABAergic Neurons of the Pedunculopontine Tegmental Nucleus Have Distinct Effects on Sleep/Wake Behavior in Mice. J Neurosci. 2017 02 01; 37(5):1352-1366.
Cholinergic, Glutamatergic, and GABAergic Neurons of the Pedunculopontine Tegmental Nucleus Have Distinct Effects on Sleep/Wake Behavior in Mice.
Peng YJ, Zhang X, Gridina A, Chupikova I, McCormick DL, Thomas RJ, Scammell TE, Kim G, Vasavda C, Nanduri J, Kumar GK, Semenza GL, Snyder SH, Prabhakar NR
Complementary roles of gasotransmitters CO and H2S in sleep apnea. Proc Natl Acad Sci U S A. 2017 02 07; 114(6):1413-1418.
Complementary roles of gasotransmitters CO and H2S in sleep apnea.
Inhibition of nitric oxide synthase produces hypothermia and depresses lipopolysaccharide fever. Am J Physiol. 1996 Aug; 271(2 Pt 2):R333-8.
Inhibition of nitric oxide synthase produces hypothermia and depresses lipopolysaccharide fever.
Scammell TE, Elmquist JK, Griffin JD, Saper CB
Ventromedial preoptic prostaglandin E2 activates fever-producing autonomic pathways. J Neurosci. 1996 Oct 01; 16(19):6246-54.
Ventromedial preoptic prostaglandin E2 activates fever-producing autonomic pathways.
Estabrooke IV, McCarthy MT, Ko E, Chou TC, Chemelli RM, Yanagisawa M, Saper CB, Scammell TE
Fos expression in orexin neurons varies with behavioral state. J Neurosci. 2001 Mar 01; 21(5):1656-62.
Fos expression in orexin neurons varies with behavioral state.
Orexin, drugs and motivated behaviors. Nat Neurosci. 2005 Oct; 8(10):1286-8.
Homeostatic, circadian, and emotional regulation of sleep. J Comp Neurol. 2005 Dec 05; 493(1):92-8.
Homeostatic, circadian, and emotional regulation of sleep.
Mechanisms of CNS response to systemic immune challenge: the febrile response. Trends Neurosci. 1997 Dec; 20(12):565-70.
Mechanisms of CNS response to systemic immune challenge: the febrile response.
Ko EM, Estabrooke IV, McCarthy M, Scammell TE
Wake-related activity of tuberomammillary neurons in rats. Brain Res. 2003 Dec 05; 992(2):220-6.
Wake-related activity of tuberomammillary neurons in rats.
Neural Circuitry of Wakefulness and Sleep. Neuron. 2017 Feb 22; 93(4):747-765.
Neural Circuitry of Wakefulness and Sleep.
Mahoney CE, Agostinelli LJ, Brooks JN, Lowell BB, Scammell TE
GABAergic Neurons of the Central Amygdala Promote Cataplexy. J Neurosci. 2017 04 12; 37(15):3995-4006.
GABAergic Neurons of the Central Amygdala Promote Cataplexy.
Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB, Yanagisawa M
Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 1999 Aug 20; 98(4):437-51.
Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.
The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci. 2001 Dec; 24(12):726-31.
The sleep switch: hypothalamic control of sleep and wakefulness.
Scammell TE, Gerashchenko DY, Mochizuki T, McCarthy MT, Estabrooke IV, Sears CA, Saper CB, Urade Y, Hayaishi O
An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons. Neuroscience. 2001; 107(4):653-63.
An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons.
Lo CC, Chou T, Penzel T, Scammell TE, Strecker RE, Stanley HE, Ivanov PCh
Common scale-invariant patterns of sleep-wake transitions across mammalian species. Proc Natl Acad Sci U S A. 2004 Dec 14; 101(50):17545-8.
Common scale-invariant patterns of sleep-wake transitions across mammalian species.
Elmquist JK, Breder CD, Sherin JE, Scammell TE, Hickey WF, Dewitt D, Saper CB
Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages. J Comp Neurol. 1997 May 05; 381(2):119-29.
Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages.
Murray BJ, Llinas R, Caplan LR, Scammell T, Pascual-Leone A
Cerebral deep venous thrombosis presenting as acute micrographia and hypophonia. Neurology. 2000 Feb 08; 54(3):751-3.
Cerebral deep venous thrombosis presenting as acute micrographia and hypophonia.
Scammell TE, Estabrooke IV, McCarthy MT, Chemelli RM, Yanagisawa M, Miller MS, Saper CB
Hypothalamic arousal regions are activated during modafinil-induced wakefulness. J Neurosci. 2000 Nov 15; 20(22):8620-8.
Hypothalamic arousal regions are activated during modafinil-induced wakefulness.
Severe acute disseminated encephalomyelitis with normal MRI at presentation. Neurology. 2000 Oct 24; 55(8):1237-8.
Severe acute disseminated encephalomyelitis with normal MRI at presentation.
Chou TC, Lee CE, Lu J, Elmquist JK, Hara J, Willie JT, Beuckmann CT, Chemelli RM, Sakurai T, Yanagisawa M, Saper CB, Scammell TE
Orexin (hypocretin) neurons contain dynorphin. J Neurosci. 2001 Oct 01; 21(19):RC168.
Orexin (hypocretin) neurons contain dynorphin.
The frustrating and mostly fruitless search for an autoimmune cause of narcolepsy. Sleep. 2006 May; 29(5):601-2.
The frustrating and mostly fruitless search for an autoimmune cause of narcolepsy.
Elmquist JK, Scammell TE, Jacobson CD, Saper CB
Distribution of Fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration. J Comp Neurol. 1996 Jul 15; 371(1):85-103.
Distribution of Fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration.
Movement disorders : official journal of the Movement Disorder Society
Mistaken diagnosis of psychogenic gait disorder in a man with status cataplecticus ("limp man syndrome"). Mov Disord. 2004 Jul; 19(7):838-840.
Mistaken diagnosis of psychogenic gait disorder in a man with status cataplecticus ("limp man syndrome").
Gooley JJ, Lu J, Chou TC, Scammell TE, Saper CB
Melanopsin in cells of origin of the retinohypothalamic tract. Nat Neurosci. 2001 Dec; 4(12):1165.
Melanopsin in cells of origin of the retinohypothalamic tract.
Olafsdóttir BR, Rye DB, Scammell TE, Matheson JK, Stefánsson K, Gulcher JR
Polymorphisms in hypocretin/orexin pathway genes and narcolepsy. Neurology. 2001 Nov 27; 57(10):1896-9.
Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.
Imbach LL, Werth E, Kallweit U, Sarnthein J, Scammell TE, Baumann CR
Inter-hemispheric oscillations in human sleep. PLoS One. 2012; 7(11):e48660.
Inter-hemispheric oscillations in human sleep.
Scammell TE, Griffin JD, Elmquist JK, Saper CB
Microinjection of a cyclooxygenase inhibitor into the anteroventral preoptic region attenuates LPS fever. Am J Physiol. 1998 03; 274(3):R783-9.
Microinjection of a cyclooxygenase inhibitor into the anteroventral preoptic region attenuates LPS fever.
Scammell TE, Nishino S, Mignot E, Saper CB
Narcolepsy and low CSF orexin (hypocretin) concentration after a diencephalic stroke. Neurology. 2001 Jun 26; 56(12):1751-3.
Narcolepsy and low CSF orexin (hypocretin) concentration after a diencephalic stroke.
Chamberlin NL, Arrigoni E, Chou TC, Scammell TE, Greene RW, Saper CB
Effects of adenosine on gabaergic synaptic inputs to identified ventrolateral preoptic neurons. Neuroscience. 2003; 119(4):913-8.
Effects of adenosine on gabaergic synaptic inputs to identified ventrolateral preoptic neurons.
Scammell TE, Arrigoni E, Thompson MA, Ronan PJ, Saper CB, Greene RW
Focal deletion of the adenosine A1 receptor in adult mice using an adeno-associated viral vector. J Neurosci. 2003 Jul 02; 23(13):5762-70.
Focal deletion of the adenosine A1 receptor in adult mice using an adeno-associated viral vector.
Effects of vagus nerve stimulation on respiration during sleep. Neurology. 2001 Oct 23; 57(8):1523-4.
Effects of vagus nerve stimulation on respiration during sleep.
Pillen S, Pizza F, Dhondt K, Scammell TE, Overeem S
Cataplexy and Its Mimics: Clinical Recognition and Management. Curr Treat Options Neurol. 2017 Jun; 19(6):23.
Cataplexy and Its Mimics: Clinical Recognition and Management.
Alexandre C, Latremoliere A, Ferreira A, Miracca G, Yamamoto M, Scammell TE, Woolf CJ
Decreased alertness due to sleep loss increases pain sensitivity in mice. Nat Med. 2017 Jun; 23(6):768-774.
Decreased alertness due to sleep loss increases pain sensitivity in mice.
Crocker A, España RA, Papadopoulou M, Saper CB, Faraco J, Sakurai T, Honda M, Mignot E, Scammell TE
Concomitant loss of dynorphin, NARP, and orexin in narcolepsy. Neurology. 2005 Oct 25; 65(8):1184-8.
Concomitant loss of dynorphin, NARP, and orexin in narcolepsy.
Orexins: looking forward to sleep, back at addiction. Nat Med. 2007 Feb; 13(2):126-8.
Orexins: looking forward to sleep, back at addiction.
Chou TC, Scammell TE, Gooley JJ, Gaus SE, Saper CB, Lu J
Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms. J Neurosci. 2003 Nov 19; 23(33):10691-702.
Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms.
España RA, McCormack SL, Mochizuki T, Scammell TE
Running promotes wakefulness and increases cataplexy in orexin knockout mice. Sleep. 2007 Nov; 30(11):1417-25.
Running promotes wakefulness and increases cataplexy in orexin knockout mice.
Arrigoni E, Crocker AJ, Saper CB, Greene RW, Scammell TE
Deletion of presynaptic adenosine A1 receptors impairs the recovery of synaptic transmission after hypoxia. Neuroscience. 2005; 132(3):575-80.
Deletion of presynaptic adenosine A1 receptors impairs the recovery of synaptic transmission after hypoxia.
Annual review of pharmacology and toxicology
Orexin receptors: pharmacology and therapeutic opportunities. Annu Rev Pharmacol Toxicol. 2011; 51:243-66.
Orexin receptors: pharmacology and therapeutic opportunities.
Grady SP, Nishino S, Czeisler CA, Hepner D, Scammell TE
Diurnal variation in CSF orexin-A in healthy male subjects. Sleep. 2006 Mar; 29(3):295-7.
Diurnal variation in CSF orexin-A in healthy male subjects.
Kantor S, Mochizuki T, Janisiewicz AM, Clark E, Nishino S, Scammell TE
Orexin neurons are necessary for the circadian control of REM sleep. Sleep. 2009 Sep; 32(9):1127-34.
Orexin neurons are necessary for the circadian control of REM sleep.
Hyperthermia induces c-fos expression in the preoptic area. Brain Res. 1993 Aug 06; 618(2):303-7.
Hyperthermia induces c-fos expression in the preoptic area.
Clark EL, Baumann CR, Cano G, Scammell TE, Mochizuki T
Feeding-elicited cataplexy in orexin knockout mice. Neuroscience. 2009 Jul 21; 161(4):970-7.
Feeding-elicited cataplexy in orexin knockout mice.
Baumann CR, Bassetti CL, Valko PO, Haybaeck J, Keller M, Clark E, Stocker R, Tolnay M, Scammell TE
Loss of hypocretin (orexin) neurons with traumatic brain injury. Ann Neurol. 2009 Oct; 66(4):555-9.
Loss of hypocretin (orexin) neurons with traumatic brain injury.
Poli F, Overeem S, Lammers GJ, Plazzi G, Lecendreux M, Bassetti CL, Dauvilliers Y, Keene D, Khatami R, Li Y, Mayer G, Nohynek H, Pahud B, Paiva T, Partinen M, Scammell TE, Shimabukuro T, Sturkenboom M, van Dinther K, Wiznitzer M, Bonhoeffer J
Narcolepsy as an adverse event following immunization: case definition and guidelines for data collection, analysis and presentation. Vaccine. 2013 Jan 30; 31(6):994-1007.
Narcolepsy as an adverse event following immunization: case definition and guidelines for data collection, analysis and presentation.
Neural circuitry engaged by prostaglandins during the sickness syndrome. Nat Neurosci. 2012 Jul 26; 15(8):1088-95.
Neural circuitry engaged by prostaglandins during the sickness syndrome.
Scammell T, Gerashchenko D, Urade Y, Onoe H, Saper C, Hayaishi O
Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7754-9.
Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2.
Diniz Behn CG, Klerman EB, Mochizuki T, Lin SC, Scammell TE
Abnormal sleep/wake dynamics in orexin knockout mice. Sleep. 2010 Mar; 33(3):297-306.
Abnormal sleep/wake dynamics in orexin knockout mice.
Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science. 2001 Dec 21; 294(5551):2511-5.
Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling.
Mochizuki T, Klerman EB, Sakurai T, Scammell TE
Elevated body temperature during sleep in orexin knockout mice. Am J Physiol Regul Integr Comp Physiol. 2006 Sep; 291(3):R533-40.
Elevated body temperature during sleep in orexin knockout mice.
Schoch SF, Werth E, Poryazova R, Scammell TE, Baumann CR, Imbach LL
Dysregulation of Sleep Behavioral States in Narcolepsy. Sleep. 2017 12 01; 40(12).
Dysregulation of Sleep Behavioral States in Narcolepsy.
Yoshida K, McCormack S, España RA, Crocker A, Scammell TE
Afferents to the orexin neurons of the rat brain. J Comp Neurol. 2006 Feb 10; 494(5):845-61.
Afferents to the orexin neurons of the rat brain.
Modafinil: a drug in search of a mechanism. Sleep. 2004 Feb 01; 27(1):11-2.
Modafinil: a drug in search of a mechanism.
Svetnik V, Snyder ES, Tao P, Scammell TE, Roth T, Lines C, Herring WJ
Insight Into Reduction of Wakefulness by Suvorexant in Patients With Insomnia: Analysis of Wake Bouts. Sleep. 2018 01 01; 41(1).
Insight Into Reduction of Wakefulness by Suvorexant in Patients With Insomnia: Analysis of Wake Bouts.
Parkinson's disease, sleepiness and hypocretin/orexin. Brain. 2008 Mar; 131(Pt 3):e91.
Parkinson's disease, sleepiness and hypocretin/orexin.
Baumann CR, Clark EL, Pedersen NP, Hecht JL, Scammell TE
Do enteric neurons make hypocretin? Regul Pept. 2008 Apr 10; 147(1-3):1-3.
Scammell TE, Willie JT, Guilleminault C, Siegel JM
A consensus definition of cataplexy in mouse models of narcolepsy. Sleep. 2009 Jan; 32(1):111-6.
A consensus definition of cataplexy in mouse models of narcolepsy.
Sleep neurobiology from a clinical perspective. Sleep. 2011 Jul 01; 34(7):845-58.
Sleep neurobiology from a clinical perspective.
Chou TC, Bjorkum AA, Gaus SE, Lu J, Scammell TE, Saper CB
Afferents to the ventrolateral preoptic nucleus. J Neurosci. 2002 Feb 01; 22(3):977-90.
Afferents to the ventrolateral preoptic nucleus.
Mochizuki T, Crocker A, McCormack S, Yanagisawa M, Sakurai T, Scammell TE
Behavioral state instability in orexin knock-out mice. J Neurosci. 2004 Jul 14; 24(28):6291-300.
Behavioral state instability in orexin knock-out mice.
Oka T, Oka K, Scammell TE, Lee C, Kelly JF, Nantel F, Elmquist JK, Saper CB
Relationship of EP(1-4) prostaglandin receptors with rat hypothalamic cell groups involved in lipopolysaccharide fever responses. J Comp Neurol. 2000 Dec 04; 428(1):20-32.
Relationship of EP(1-4) prostaglandin receptors with rat hypothalamic cell groups involved in lipopolysaccharide fever responses.