Corresponding Member of the Faculty of Medicine
McLoughlin RM, Solinga RM, Rich J, Zaleski KJ, Cocchiaro JL, Risley A, Tzianabos AO, Lee JC
Proceedings of the National Academy of Sciences of the United States of America
CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10408-10413.
CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections.
NorB, an efflux pump in Staphylococcus aureus strain MW2, contributes to bacterial fitness in abscesses. J Bacteriol. 2008 Nov; 190(21):7123-9.
NorB, an efflux pump in Staphylococcus aureus strain MW2, contributes to bacterial fitness in abscesses.
Defects in innate immunity predispose C57BL/6J-Leprdb/Leprdb mice to infection by Staphylococcus aureus. Infect Immun. 2009 Mar; 77(3):1008-14.
Defects in innate immunity predispose C57BL/6J-Leprdb/Leprdb mice to infection by Staphylococcus aureus.
Wang X, Thompson CD, Weidenmaier C, Lee JC
Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform. Nat Commun. 2018 04 11; 9(1):1379.
Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform.
Kalashnikov M, Lee JC, Campbell J, Sharon A, Sauer-Budge AF
A microfluidic platform for rapid, stress-induced antibiotic susceptibility testing of Staphylococcus aureus. Lab Chip. 2012 Nov 07; 12(21):4523-32.
A microfluidic platform for rapid, stress-induced antibiotic susceptibility testing of Staphylococcus aureus.
Development of a vesicle-based vaccine platform against Staphylococcus aureus
Becker SC, Roach DR, Chauhan VS, Shen Y, Foster-Frey J, Powell AM, Bauchan G, Lease RA, Mohammadi H, Harty WJ, Simmons C, Schmelcher M, Camp M, Dong S, Baker JR, Sheen TR, Doran KS, Pritchard DG, Almeida RA, Nelson DC, Marriott I, Lee JC, Donovan DM
Triple-acting Lytic Enzyme Treatment of Drug-Resistant and Intracellular Staphylococcus aureus. Sci Rep. 2016 04 28; 6:25063.
Triple-acting Lytic Enzyme Treatment of Drug-Resistant and Intracellular Staphylococcus aureus.
Moskowitz JS, Blaisse MR, Samuel RE, Hsu HP, Harris MB, Martin SD, Lee JC, Spector M, Hammond PT
The effectiveness of the controlled release of gentamicin from polyelectrolyte multilayers in the treatment of Staphylococcus aureus infection in a rabbit bone model. Biomaterials. 2010 Aug; 31(23):6019-30.
The effectiveness of the controlled release of gentamicin from polyelectrolyte multilayers in the treatment of Staphylococcus aureus infection in a rabbit bone model.
Tuchscherr LP, Buzzola FR, Alvarez LP, Caccuri RL, Lee JC, Sordelli DO
Capsule-negative Staphylococcus aureus induces chronic experimental mastitis in mice. Infect Immun. 2005 Dec; 73(12):7932-7.
Capsule-negative Staphylococcus aureus induces chronic experimental mastitis in mice.
Montgomery CP, Boyle-Vavra S, Adem PV, Lee JC, Husain AN, Clasen J, Daum RS
Comparison of virulence in community-associated methicillin-resistant Staphylococcus aureus pulsotypes USA300 and USA400 in a rat model of pneumonia. J Infect Dis. 2008 Aug 15; 198(4):561-70.
Comparison of virulence in community-associated methicillin-resistant Staphylococcus aureus pulsotypes USA300 and USA400 in a rat model of pneumonia.
International journal of antimicrobial agents
Vaccination and passive immunisation against Staphylococcus aureus. Int J Antimicrob Agents. 2008 Nov; 32 Suppl 1:S71-8.
Vaccination and passive immunisation against Staphylococcus aureus.
Skurnik D, Merighi M, Grout M, Gadjeva M, Maira-Litran T, Ericsson M, Goldmann DA, Huang SS, Datta R, Lee JC, Pier GB
Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice. J Clin Invest. 2010 Sep; 120(9):3220-33.
Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice.
Professor of Medicine (Microbiology and Molecular Genetics)
Lecturer on Health Care Policy, Part-time
Sir William Osler Professor of Ophthalmology
Senior Lecturer on Population Medicine, Part-time
Member of the Affiliated Faculty of Health Sciences and Technology
Keinhörster D, Salzer A, Duque-Jaramillo A, George SE, Marincola G, Lee JC, Weidenmaier C, Wolz C
Revisiting the regulation of the capsular polysaccharide biosynthesis gene cluster in Staphylococcus aureus. Mol Microbiol. 2019 10; 112(4):1083-1099.
Revisiting the regulation of the capsular polysaccharide biosynthesis gene cluster in Staphylococcus aureus.
Staphylococcus aureus extracellular vesicles: host-pathogen interactions
Orchestration of human macrophage NLRP3 inflammasome activation by Staphylococcus aureus extracellular vesicles. Proc Natl Acad Sci U S A. 2020 02 11; 117(6):3174-3184.
Orchestration of human macrophage NLRP3 inflammasome activation by Staphylococcus aureus extracellular vesicles.
Staphylococcus aureus Extracellular Vesicles: A Story of Toxicity and the Stress of 2020. Toxins (Basel). 2021 01 20; 13(2).
Staphylococcus aureus Extracellular Vesicles: A Story of Toxicity and the Stress of 2020.
Sau S, Bhasin N, Wann ER, Lee JC, Foster TJ, Lee CY
The Staphylococcus aureus allelic genetic loci for serotype 5 and 8 capsule expression contain the type-specific genes flanked by common genes. Microbiology (Reading). 1997 Jul; 143 ( Pt 7):2395-2405.
The Staphylococcus aureus allelic genetic loci for serotype 5 and 8 capsule expression contain the type-specific genes flanked by common genes.
Karauzum H, Venkatasubramaniam A, Adhikari RP, Kort T, Holtsberg FW, Mukherjee I, Mednikov M, Ortines R, Nguyen NTQ, Doan TMN, Diep BA, Lee JC, Aman MJ
IBT-V02: A Multicomponent Toxoid Vaccine Protects Against Primary and Secondary Skin Infections Caused by Staphylococcus aureus. Front Immunol. 2021; 12:624310.
IBT-V02: A Multicomponent Toxoid Vaccine Protects Against Primary and Secondary Skin Infections Caused by Staphylococcus aureus.
Altwiley D, Brignoli T, Edwards A, Recker M, Lee JC, Massey RC
A functional menadione biosynthesis pathway is required for capsule production by Staphylococcus aureus. Microbiology (Reading). 2021 11; 167(11).
A functional menadione biosynthesis pathway is required for capsule production by Staphylococcus aureus.
Shibamura-Fujiogi M, Wang X, Maisat W, Koutsogiannaki S, Li Y, Chen Y, Lee JC, Yuki K
GltS regulates biofilm formation in methicillin-resistant Staphylococcus aureus. Commun Biol. 2022 11 23; 5(1):1284.
GltS regulates biofilm formation in methicillin-resistant Staphylococcus aureus.
Contribution of Extracellular Membrane Vesicles To the Secretome of Staphylococcus aureus. mBio. 2023 02 28; 14(1):e0357122.
Contribution of Extracellular Membrane Vesicles To the Secretome of Staphylococcus aureus.
Key FM, Khadka VD, Romo-González C, Blake KJ, Deng L, Lynn TC, Lee JC, Chiu IM, García-Romero MT, Lieberman TD
On-person adaptive evolution of Staphylococcus aureus during treatment for atopic dermatitis. Cell Host Microbe. 2023 04 12; 31(4):593-603.e7.
On-person adaptive evolution of Staphylococcus aureus during treatment for atopic dermatitis.
Wang X, Uppu DS, Dickey SW, Burgin DJ, Otto M, Lee JC
bioRxiv : the preprint server for biology
Staphylococcus aureus Delta Toxin Modulates both Extracellular Membrane Vesicle Biogenesis and Amyloid Formation. bioRxiv. 2023 Mar 23.
Staphylococcus aureus Delta Toxin Modulates both Extracellular Membrane Vesicle Biogenesis and Amyloid Formation.
Staphylococcus aureus delta toxin modulates both extracellular membrane vesicle biogenesis and amyloid formation. mBio. 2023 10 31; 14(5):e0174823.
Staphylococcus aureus delta toxin modulates both extracellular membrane vesicle biogenesis and amyloid formation.
Staphylococcus aureus membrane vesicles: an evolving story. Trends Microbiol. 2024 11; 32(11):1096-1105.
Staphylococcus aureus membrane vesicles: an evolving story.
Hymøller KM, Christiansen SH, Schlosser AG, Skov Sørensen UB, Lee JC, Thiel S
Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid. Front Immunol. 2024; 15:1504886.
Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid.
The zwitterionic cell wall teichoic acid of Staphylococcus aureus provokes skin abscesses in mice by a novel CD4+ T-cell-dependent mechanism. PLoS One. 2010 Oct 07; 5(10):e13227.
The zwitterionic cell wall teichoic acid of Staphylococcus aureus provokes skin abscesses in mice by a novel CD4+ T-cell-dependent mechanism.
Chen Q, Dintaman J, Lees A, Sen G, Schwartz D, Shirtliff ME, Park S, Lee JC, Mond JJ, Snapper CM
Novel synthetic (poly)glycerolphosphate-based antistaphylococcal conjugate vaccine. Infect Immun. 2013 Jul; 81(7):2554-61.
Novel synthetic (poly)glycerolphosphate-based antistaphylococcal conjugate vaccine.
Reduced neutrophil apoptosis in diabetic mice during staphylococcal infection leads to prolonged Tnfa production and reduced neutrophil clearance. PLoS One. 2011; 6(8):e23633.
Reduced neutrophil apoptosis in diabetic mice during staphylococcal infection leads to prolonged Tnfa production and reduced neutrophil clearance.
Jansen A, Szekat C, Schröder W, Wolz C, Goerke C, Lee JC, Türck M, Bierbaum G
Production of capsular polysaccharide does not influence Staphylococcus aureus vancomycin susceptibility. BMC Microbiol. 2013 Mar 22; 13:65.
Production of capsular polysaccharide does not influence Staphylococcus aureus vancomycin susceptibility.
Corrigendum: Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid. Front Immunol. 2025; 16:1568032.
Corrigendum: Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid.
Lattar SM, Noto Llana M, Denoël P, Germain S, Buzzola FR, Lee JC, Sordelli DO
Protein antigens increase the protective efficacy of a capsule-based vaccine against Staphylococcus aureus in a rat model of osteomyelitis. Infect Immun. 2014 Jan; 82(1):83-91.
Protein antigens increase the protective efficacy of a capsule-based vaccine against Staphylococcus aureus in a rat model of osteomyelitis.
Wacker M, Wang L, Kowarik M, Dowd M, Lipowsky G, Faridmoayer A, Shields K, Park S, Alaimo C, Kelley KA, Braun M, Quebatte J, Gambillara V, Carranza P, Steffen M, Lee JC
Prevention of Staphylococcus aureus infections by glycoprotein vaccines synthesized in Escherichia coli. J Infect Dis. 2014 May 15; 209(10):1551-61.
Prevention of Staphylococcus aureus infections by glycoprotein vaccines synthesized in Escherichia coli.
An experimental vaccine that targets staphylococcal virulence. Trends Microbiol. 1998 Dec; 6(12):461-3.
An experimental vaccine that targets staphylococcal virulence.
Boardman AK, Wong WS, Premasiri WR, Ziegler LD, Lee JC, Miljkovic M, Klapperich CM, Sharon A, Sauer-Budge AF
Rapid Detection of Bacteria from Blood with Surface-Enhanced Raman Spectroscopy. Anal Chem. 2016 08 16; 88(16):8026-35.
Rapid Detection of Bacteria from Blood with Surface-Enhanced Raman Spectroscopy.
Premasiri WR, Lee JC, Sauer-Budge A, Théberge R, Costello CE, Ziegler LD
The biochemical origins of the surface-enhanced Raman spectra of bacteria: a metabolomics profiling by SERS. Anal Bioanal Chem. 2016 Jul; 408(17):4631-47.
The biochemical origins of the surface-enhanced Raman spectra of bacteria: a metabolomics profiling by SERS.
Optimization of Stress-Based Microfluidic Testing for Methicillin Resistance in Staphylococcusaureus Strains. Diagnostics (Basel). 2018 Apr 17; 8(2).
Optimization of Stress-Based Microfluidic Testing for Methicillin Resistance in Staphylococcusaureus Strains.
Kalashnikov M, Mueller M, McBeth C, Lee JC, Campbell J, Sharon A, Sauer-Budge AF
Rapid phenotypic stress-based microfluidic antibiotic susceptibility testing of Gram-negative clinical isolates. Sci Rep. 2017 08 14; 7(1):8031.
Rapid phenotypic stress-based microfluidic antibiotic susceptibility testing of Gram-negative clinical isolates.
Tatara AM, Lightbown S, Kang S, Jung WH, Ijaz H, Lee JC, Nelson SB, Super M, Mooney DJ
Scaffold vaccination for prevention of orthopedic device infection. Proc Natl Acad Sci U S A. 2025 Nov 11; 122(45):e2409562122.
Scaffold vaccination for prevention of orthopedic device infection.
Hanses F, Roux C, Dunman PM, Salzberger B, Lee JC
Staphylococcus aureus gene expression in a rat model of infective endocarditis. Genome Med. 2014; 6(10):93.
Staphylococcus aureus gene expression in a rat model of infective endocarditis.
Antibodies to Staphylococcus aureus serotype 8 capsular polysaccharide react with and protect against serotype 5 and 8 isolates. Infect Immun. 2014 Dec; 82(12):5049-55.
Antibodies to Staphylococcus aureus serotype 8 capsular polysaccharide react with and protect against serotype 5 and 8 isolates.
Li W, Ulm H, Rausch M, Li X, O'Riordan K, Lee JC, Schneider T, Müller CE
International journal of medical microbiology : IJMM
Analysis of the Staphylococcus aureus capsule biosynthesis pathway in vitro: characterization of the UDP-GlcNAc C6 dehydratases CapD and CapE and identification of enzyme inhibitors. Int J Med Microbiol. 2014 Nov; 304(8):958-69.
Analysis of the Staphylococcus aureus capsule biosynthesis pathway in vitro: characterization of the UDP-GlcNAc C6 dehydratases CapD and CapE and identification of enzyme inhibitors.
Boyle-Vavra S, Li X, Alam MT, Read TD, Sieth J, Cywes-Bentley C, Dobbins G, David MZ, Kumar N, Eells SJ, Miller LG, Boxrud DJ, Chambers HF, Lynfield R, Lee JC, Daum RS
USA300 and USA500 clonal lineages of Staphylococcus aureus do not produce a capsular polysaccharide due to conserved mutations in the cap5 locus. mBio. 2015 Apr 07; 6(2).
USA300 and USA500 clonal lineages of Staphylococcus aureus do not produce a capsular polysaccharide due to conserved mutations in the cap5 locus.
Hirschhausen N, Block D, Bianconi I, Bragonzi A, Birtel J, Lee JC, Dübbers A, Küster P, Kahl J, Peters G, Kahl BC
Extended Staphylococcus aureus persistence in cystic fibrosis is associated with bacterial adaptation. Int J Med Microbiol. 2013 Dec; 303(8):685-92.
Extended Staphylococcus aureus persistence in cystic fibrosis is associated with bacterial adaptation.
Misawa Y, Kelley KA, Wang X, Wang L, Park WB, Birtel J, Saslowsky D, Lee JC
Staphylococcus aureus Colonization of the Mouse Gastrointestinal Tract Is Modulated by Wall Teichoic Acid, Capsule, and Surface Proteins. PLoS Pathog. 2015 Jul; 11(7):e1005061.
Staphylococcus aureus Colonization of the Mouse Gastrointestinal Tract Is Modulated by Wall Teichoic Acid, Capsule, and Surface Proteins.
George SE, Nguyen T, Geiger T, Weidenmaier C, Lee JC, Liese J, Wolz C
Phenotypic heterogeneity and temporal expression of the capsular polysaccharide in Staphylococcus aureus. Mol Microbiol. 2015 Dec; 98(6):1073-88.
Phenotypic heterogeneity and temporal expression of the capsular polysaccharide in Staphylococcus aureus.
Li X, Wang X, Thompson CD, Park S, Park WB, Lee JC
Preclinical Efficacy of Clumping Factor A in Prevention of Staphylococcus aureus Infection. mBio. 2016 Feb 02; 7(1):e02232-15.
Preclinical Efficacy of Clumping Factor A in Prevention of Staphylococcus aureus Infection.
Saslowsky DE, Thiagarajah JR, McCormick BA, Lee JC, Lencer WI
Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion. Mol Biol Cell. 2016 Apr 01; 27(7):1120-30.
Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion.
Methods in molecular biology (Clifton, N.J.)
Murine Models of Bacteremia and Surgical Wound Infection for the Evaluation of Staphylococcus aureus Vaccine Candidates. Methods Mol Biol. 2016; 1403:409-18.
Murine Models of Bacteremia and Surgical Wound Infection for the Evaluation of Staphylococcus aureus Vaccine Candidates.
Kuipers A, Stapels DAC, Weerwind LT, Ko YP, Ruyken M, Lee JC, van Kessel KPM, Rooijakkers SHM
The Staphylococcus aureus polysaccharide capsule and Efb-dependent fibrinogen shield act in concert to protect against phagocytosis. Microbiology (Reading). 2016 07; 162(7):1185-1194.
The Staphylococcus aureus polysaccharide capsule and Efb-dependent fibrinogen shield act in concert to protect against phagocytosis.
A New Approach to Staphylococcus aureus Vaccine Development - Resubmission 01
NASAL COLONIZATION BY S AUREUS--MECHANISMS AND IMMUNITY
STAPHYLOCOCCUS AUREUS: CAPSULAR ANTIGENS AND IMMUNITY
2005 Staphylococcal Diseases Gordon Research Conferences
Genetic Analysis of S. aureus Capsule Production
ROLE OF STAPHYLOCOCCUS AUREUS CAPSULES IN PATHOGENESIS
Novel Bioconjugate Vaccines to Prevent Staphylococcus aureus Infection
GENETIC ANALYSIS OF S. AUREUS CAPSULE PRODUCTION
Biological relevance of capsule expression by S. aureus
Schmelcher M, Shen Y, Nelson DC, Eugster MR, Eichenseher F, Hanke DC, Loessner MJ, Dong S, Pritchard DG, Lee JC, Becker SC, Foster-Frey J, Donovan DM
The Journal of antimicrobial chemotherapy
Evolutionarily distinct bacteriophage endolysins featuring conserved peptidoglycan cleavage sites protect mice from MRSA infection. J Antimicrob Chemother. 2015 May; 70(5):1453-65.
Evolutionarily distinct bacteriophage endolysins featuring conserved peptidoglycan cleavage sites protect mice from MRSA infection.
Current topics in microbiology and immunology
Structure and Function of Surface Polysaccharides of Staphylococcus aureus. Curr Top Microbiol Immunol. 2017; 409:57-93.
Structure and Function of Surface Polysaccharides of Staphylococcus aureus.
Adhikari RP, Thompson CD, Aman MJ, Lee JC
Protective efficacy of a novel alpha hemolysin subunit vaccine (AT62) against Staphylococcus aureus skin and soft tissue infections. Vaccine. 2016 12 07; 34(50):6402-6407.
Protective efficacy of a novel alpha hemolysin subunit vaccine (AT62) against Staphylococcus aureus skin and soft tissue infections.
Schwartbeck B, Birtel J, Treffon J, Langhanki L, Mellmann A, Kale D, Kahl J, Hirschhausen N, Neumann C, Lee JC, Götz F, Rohde H, Henke H, Küster P, Peters G, Kahl BC
Dynamic in vivo mutations within the ica operon during persistence of Staphylococcus aureus in the airways of cystic fibrosis patients. PLoS Pathog. 2016 Nov; 12(11):e1006024.
Dynamic in vivo mutations within the ica operon during persistence of Staphylococcus aureus in the airways of cystic fibrosis patients.
Liu B, Park S, Thompson CD, Li X, Lee JC
Antibodies to Staphylococcus aureus capsular polysaccharides 5 and 8 perform similarly in vitro but are functionally distinct in vivo. Virulence. 2017 08 18; 8(6):859-874.
Antibodies to Staphylococcus aureus capsular polysaccharides 5 and 8 perform similarly in vitro but are functionally distinct in vivo.
Regulation of Staphylococcus aureus capsular polysaccharide expression by agr and sarA. Infect Immun. 2002 Feb; 70(2):444-50.
Regulation of Staphylococcus aureus capsular polysaccharide expression by agr and sarA.
Development of Antistaphylococcal Vaccines. Curr Infect Dis Rep. 2001 Dec; 3(6):517-524.
Development of Antistaphylococcal Vaccines.
Cheng BL, Nielsen TB, Pantapalangkoor P, Zhao F, Lee JC, Montgomery CP, Luna B, Spellberg B, Daum RS
Evaluation of serotypes 5 and 8 capsular polysaccharides in protection against Staphylococcus aureus in murine models of infection. Hum Vaccin Immunother. 2017 07 03; 13(7):1609-1614.
Evaluation of serotypes 5 and 8 capsular polysaccharides in protection against Staphylococcus aureus in murine models of infection.
Kneidinger B, O'Riordan K, Li J, Brisson JR, Lee JC, Lam JS
Three highly conserved proteins catalyze the conversion of UDP-N-acetyl-D-glucosamine to precursors for the biosynthesis of O antigen in Pseudomonas aeruginosa O11 and capsule in Staphylococcus aureus type 5. Implications for the UDP-N-acetyl-L-fucosamine biosynthetic pathway. J Biol Chem. 2003 Feb 07; 278(6):3615-27.
Three highly conserved proteins catalyze the conversion of UDP-N-acetyl-D-glucosamine to precursors for the biosynthesis of O antigen in Pseudomonas aeruginosa O11 and capsule in Staphylococcus aureus type 5. Implications for the UDP-N-acetyl-L-fucosamine biosynthetic pathway.
Watts A, Ke D, Wang Q, Pillay A, Nicholson-Weller A, Lee JC
Staphylococcus aureus strains that express serotype 5 or serotype 8 capsular polysaccharides differ in virulence. Infect Immun. 2005 Jun; 73(6):3502-11.
Staphylococcus aureus strains that express serotype 5 or serotype 8 capsular polysaccharides differ in virulence.
Staphylococcus aureus NorD, a putative efflux pump coregulated with the Opp1 oligopeptide permease, contributes selectively to fitness in vivo. J Bacteriol. 2012 Dec; 194(23):6586-93.
Staphylococcus aureus NorD, a putative efflux pump coregulated with the Opp1 oligopeptide permease, contributes selectively to fitness in vivo.
Infectious disease clinics of North America
Staphylococcal vaccines and immunotherapies. Infect Dis Clin North Am. 2009 Mar; 23(1):153-71.
Staphylococcal vaccines and immunotherapies.
Takeuchi F, Watanabe S, Baba T, Yuzawa H, Ito T, Morimoto Y, Kuroda M, Cui L, Takahashi M, Ankai A, Baba S, Fukui S, Lee JC, Hiramatsu K
Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species. J Bacteriol. 2005 Nov; 187(21):7292-308.
Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species.
The pathogenesis of Staphylococcus aureus infection in the diabetic NOD mouse. Diabetes. 2005 Oct; 54(10):2904-10.
The pathogenesis of Staphylococcus aureus infection in the diabetic NOD mouse.
Staphylococcus aureus capsular polysaccharides. Clin Microbiol Rev. 2004 Jan; 17(1):218-34.
Staphylococcus aureus capsular polysaccharides.
McLoughlin RM, Lee JC, Kasper DL, Tzianabos AO
Journal of immunology (Baltimore, Md. : 1950)
IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection. J Immunol. 2008 Jul 15; 181(2):1323-32.
IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection.
Kalka-Moll WM, Lee JC, Fabri M, Seifert H
Intrafamilial outbreak of subcutaneous abscesses caused by PVL-positive methicillin-sensitive Staphylococcus aureus. J Infect. 2008 Sep; 57(3):278-80.
Intrafamilial outbreak of subcutaneous abscesses caused by PVL-positive methicillin-sensitive Staphylococcus aureus.
Park S, Kelley KA, Vinogradov E, Solinga R, Weidenmaier C, Misawa Y, Lee JC
Characterization of the structure and biological functions of a capsular polysaccharide produced by Staphylococcus saprophyticus. J Bacteriol. 2010 Sep; 192(18):4618-26.
Characterization of the structure and biological functions of a capsular polysaccharide produced by Staphylococcus saprophyticus.
Cocchiaro JL, Gomez MI, Risley A, Solinga R, Sordelli DO, Lee JC
Molecular characterization of the capsule locus from non-typeable Staphylococcus aureus. Mol Microbiol. 2006 Feb; 59(3):948-60.
Molecular characterization of the capsule locus from non-typeable Staphylococcus aureus.
Lee JC, Park JS, Shepherd SE, Carey V, Fattom A
Protective efficacy of antibodies to the Staphylococcus aureus type 5 capsular polysaccharide in a modified model of endocarditis in rats. Infect Immun. 1997 Oct; 65(10):4146-51.
Protective efficacy of antibodies to the Staphylococcus aureus type 5 capsular polysaccharide in a modified model of endocarditis in rats.
Flahaut S, Vinogradov E, Kelley KA, Brennan S, Hiramatsu K, Lee JC
Structural and biological characterization of a capsular polysaccharide produced by Staphylococcus haemolyticus. J Bacteriol. 2008 Mar; 190(5):1649-57.
Structural and biological characterization of a capsular polysaccharide produced by Staphylococcus haemolyticus.
Tuchscherr LP, Buzzola FR, Alvarez LP, Lee JC, Sordelli DO
Antibodies to capsular polysaccharide and clumping factor A prevent mastitis and the emergence of unencapsulated and small-colony variants of Staphylococcus aureus in mice. Infect Immun. 2008 Dec; 76(12):5738-44.
Antibodies to capsular polysaccharide and clumping factor A prevent mastitis and the emergence of unencapsulated and small-colony variants of Staphylococcus aureus in mice.
Risley AL, Loughman A, Cywes-Bentley C, Foster TJ, Lee JC
Capsular polysaccharide masks clumping factor A-mediated adherence of Staphylococcus aureus to fibrinogen and platelets. J Infect Dis. 2007 Sep 15; 196(6):919-27.
Capsular polysaccharide masks clumping factor A-mediated adherence of Staphylococcus aureus to fibrinogen and platelets.
Schaffer AC, Solinga RM, Cocchiaro J, Portoles M, Kiser KB, Risley A, Randall SM, Valtulina V, Speziale P, Walsh E, Foster T, Lee JC
Immunization with Staphylococcus aureus clumping factor B, a major determinant in nasal carriage, reduces nasal colonization in a murine model. Infect Immun. 2006 Apr; 74(4):2145-53.
Immunization with Staphylococcus aureus clumping factor B, a major determinant in nasal carriage, reduces nasal colonization in a murine model.
Pozzi C, Wilk K, Lee JC, Gening M, Nifantiev N, Pier GB
Opsonic and protective properties of antibodies raised to conjugate vaccines targeting six Staphylococcus aureus antigens. PLoS One. 2012; 7(10):e46648.
Opsonic and protective properties of antibodies raised to conjugate vaccines targeting six Staphylococcus aureus antigens.