Lee, Jean
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CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections.
PubMed Identifier: 16801559
author list: McLoughlin RM, Solinga RM, Rich J, Zaleski KJ, Cocchiaro JL, Risley A, Tzianabos AO, Lee JC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10408-10413.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2006-06-26T00:00:00
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type: Academic Article
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NorB, an efflux pump in Staphylococcus aureus strain MW2, contributes to bacterial fitness in abscesses.
PubMed Identifier: 18723624
author list: Ding Y, Onodera Y, Lee JC, Hooper DC
published in: Journal of bacteriology
information resource reference: NorB, an efflux pump in Staphylococcus aureus strain MW2, contributes to bacterial fitness in abscesses. J Bacteriol. 2008 Nov; 190(21):7123-9.
journal title abbreviation: J Bacteriol
publication date: 2008-08-22T00:00:00
year: 2008
type: Academic Article
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Defects in innate immunity predispose C57BL/6J-Leprdb/Leprdb mice to infection by Staphylococcus aureus.
PubMed Identifier: 19103772
author list: Park S, Rich J, Hanses F, Lee JC
published in: Infection and immunity
information resource reference: Defects in innate immunity predispose C57BL/6J-Leprdb/Leprdb mice to infection by Staphylococcus aureus. Infect Immun. 2009 Mar; 77(3):1008-14.
journal title abbreviation: Infect Immun
publication date: 2008-12-22T00:00:00
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Authorship 1057553
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linked author: Lee, Jean
linked information resource: Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform.

Authorship 1059464
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linked author: Lee, Jean
linked information resource: A microfluidic platform for rapid, stress-induced antibiotic susceptibility testing of Staphylococcus aureus.

Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform.
PubMed Identifier: 29643357
author list: Wang X, Thompson CD, Weidenmaier C, Lee JC
published in: Nature communications
information resource reference: Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform. Nat Commun. 2018 04 11; 9(1):1379.
journal title abbreviation: Nat Commun
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year: 2018
type: Academic Article
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A microfluidic platform for rapid, stress-induced antibiotic susceptibility testing of Staphylococcus aureus.
PubMed Identifier: 22968495
author list: Kalashnikov M, Lee JC, Campbell J, Sharon A, Sauer-Budge AF
published in: Lab on a chip
information resource reference: A microfluidic platform for rapid, stress-induced antibiotic susceptibility testing of Staphylococcus aureus. Lab Chip. 2012 Nov 07; 12(21):4523-32.
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publication date: 2012-11-07T00:00:00
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Development of a vesicle-based vaccine platform against Staphylococcus aureus
end date: 2021-04-30
principal investigator name: LEE, JEAN CLAIRE
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contributes to: Development of a vesicle-based vaccine platform against Staphylococcus aureus

Authorship 1068481
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linked author: Lee, Jean
linked information resource: Triple-acting Lytic Enzyme Treatment of Drug-Resistant and Intracellular Staphylococcus aureus.

Triple-acting Lytic Enzyme Treatment of Drug-Resistant and Intracellular Staphylococcus aureus.
PubMed Identifier: 27121552
author list: Becker SC, Roach DR, Chauhan VS, Shen Y, Foster-Frey J, Powell AM, Bauchan G, Lease RA, Mohammadi H, Harty WJ, Simmons C, Schmelcher M, Camp M, Dong S, Baker JR, Sheen TR, Doran KS, Pritchard DG, Almeida RA, Nelson DC, Marriott I, Lee JC, Donovan DM
published in: Scientific reports
information resource reference: Triple-acting Lytic Enzyme Treatment of Drug-Resistant and Intracellular Staphylococcus aureus. Sci Rep. 2016 04 28; 6:25063.
journal title abbreviation: Sci Rep
publication date: 2016-04-28T00:00:00
year: 2016
type: Academic Article
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The effectiveness of the controlled release of gentamicin from polyelectrolyte multilayers in the treatment of Staphylococcus aureus infection in a rabbit bone model.
PubMed Identifier: 20488534
author list: Moskowitz JS, Blaisse MR, Samuel RE, Hsu HP, Harris MB, Martin SD, Lee JC, Spector M, Hammond PT
published in: Biomaterials
information resource reference: The effectiveness of the controlled release of gentamicin from polyelectrolyte multilayers in the treatment of Staphylococcus aureus infection in a rabbit bone model. Biomaterials. 2010 Aug; 31(23):6019-30.
journal title abbreviation: Biomaterials
publication date: 2010-05-21T00:00:00
year: 2010
type: Academic Article
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type: Document
type: Information Resource

Tatara, Alexander
eCommons Login: AMT49
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Capsule-negative Staphylococcus aureus induces chronic experimental mastitis in mice.
PubMed Identifier: 16299284
author list: Tuchscherr LP, Buzzola FR, Alvarez LP, Caccuri RL, Lee JC, Sordelli DO
published in: Infection and immunity
information resource reference: Capsule-negative Staphylococcus aureus induces chronic experimental mastitis in mice. Infect Immun. 2005 Dec; 73(12):7932-7.
journal title abbreviation: Infect Immun
publication date: 2005-12-01T00:00:00
year: 2005
type: Academic Article
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Comparison of virulence in community-associated methicillin-resistant Staphylococcus aureus pulsotypes USA300 and USA400 in a rat model of pneumonia.
PubMed Identifier: 18598194
author list: Montgomery CP, Boyle-Vavra S, Adem PV, Lee JC, Husain AN, Clasen J, Daum RS
published in: The Journal of infectious diseases
information resource reference: Comparison of virulence in community-associated methicillin-resistant Staphylococcus aureus pulsotypes USA300 and USA400 in a rat model of pneumonia. J Infect Dis. 2008 Aug 15; 198(4):561-70.
journal title abbreviation: J Infect Dis
publication date: 2008-08-15T00:00:00
year: 2008
type: Academic Article
type: Article
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Vaccination and passive immunisation against Staphylococcus aureus.
PubMed Identifier: 18757184
author list: Schaffer AC, Lee JC
published in: International journal of antimicrobial agents
information resource reference: Vaccination and passive immunisation against Staphylococcus aureus. Int J Antimicrob Agents. 2008 Nov; 32 Suppl 1:S71-8.
journal title abbreviation: Int J Antimicrob Agents
publication date: 2008-08-30T00:00:00
year: 2008
type: Academic Article
type: Article
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Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice.
PubMed Identifier: 20739753
author list: Skurnik D, Merighi M, Grout M, Gadjeva M, Maira-Litran T, Ericsson M, Goldmann DA, Huang SS, Datta R, Lee JC, Pier GB
published in: The Journal of clinical investigation
information resource reference: Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice. J Clin Invest. 2010 Sep; 120(9):3220-33.
journal title abbreviation: J Clin Invest
publication date: 2010-08-25T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
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Bacterial Capsules
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Staphylococcus aureus
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Staphylococcal Vaccines
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Polysaccharides, Bacterial
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Staphylococcal Infections
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Cywes-Bentley, Colette
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Pier, Gerald
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Issa, Nicolas
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Zhao, Bo
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Schaffer, Adam
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Bond, Sheila
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Gilmore, Michael
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Huang, Susan
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Hooper, David
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Lieberman, Tami
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Truong-Bolduc, Que
eCommons Login: QCT1
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Yuki, Koichi
eCommons Login: KY9
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Authorship 1169892
type: Authorship
author rank in publication: 6
linked author: Lee, Jean
linked information resource: Revisiting the regulation of the capsular polysaccharide biosynthesis gene cluster in Staphylococcus aureus.

Revisiting the regulation of the capsular polysaccharide biosynthesis gene cluster in Staphylococcus aureus.
PubMed Identifier: 31283061
author list: Keinhörster D, Salzer A, Duque-Jaramillo A, George SE, Marincola G, Lee JC, Weidenmaier C, Wolz C
published in: Molecular microbiology
information resource reference: Revisiting the regulation of the capsular polysaccharide biosynthesis gene cluster in Staphylococcus aureus. Mol Microbiol. 2019 10; 112(4):1083-1099.
journal title abbreviation: Mol Microbiol
publication date: 2019-07-25T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Staphylococcus aureus extracellular vesicles: host-pathogen interactions
end date: 2023-08-31
principal investigator name: LEE, JEAN CLAIRE
start date: 2019-09-01
type: Grant
sponsor award id: R01AI141885

Principal Investigator
type: Researcher Role
researcher role of: Lee, Jean
contributes to: Staphylococcus aureus extracellular vesicles: host-pathogen interactions

Instructor in Medicine, Part-time
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Instructor in Medicine
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position in division: Infectious Disease
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position in organization: Brigham and Women's Hospital

Authorship 1222164
type: Authorship
author rank in publication: 3
linked author: Lee, Jean
linked information resource: Orchestration of human macrophage NLRP3 inflammasome activation by Staphylococcus aureus extracellular vesicles.

Orchestration of human macrophage NLRP3 inflammasome activation by Staphylococcus aureus extracellular vesicles.
PubMed Identifier: 31988111
author list: Wang X, Eagen WJ, Lee JC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Orchestration of human macrophage NLRP3 inflammasome activation by Staphylococcus aureus extracellular vesicles. Proc Natl Acad Sci U S A. 2020 02 11; 117(6):3174-3184.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2020-01-27T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1323405
type: Authorship
author rank in publication: 4
linked author: Lee, Jean
linked information resource: Staphylococcus aureus Extracellular Vesicles: A Story of Toxicity and the Stress of 2020.

Staphylococcus aureus Extracellular Vesicles: A Story of Toxicity and the Stress of 2020.
PubMed Identifier: 33498438
author list: Wang X, Koffi PF, English OF, Lee JC
published in: Toxins
information resource reference: Staphylococcus aureus Extracellular Vesicles: A Story of Toxicity and the Stress of 2020. Toxins (Basel). 2021 01 20; 13(2).
journal title abbreviation: Toxins (Basel)
publication date: 2021-01-20T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1336702
type: Authorship
author rank in publication: 4
linked author: Lee, Jean
linked information resource: The Staphylococcus aureus allelic genetic loci for serotype 5 and 8 capsule expression contain the type-specific genes flanked by common genes.

The Staphylococcus aureus allelic genetic loci for serotype 5 and 8 capsule expression contain the type-specific genes flanked by common genes.
PubMed Identifier: 9245821
author list: Sau S, Bhasin N, Wann ER, Lee JC, Foster TJ, Lee CY
published in: Microbiology (Reading, England)
information resource reference: The Staphylococcus aureus allelic genetic loci for serotype 5 and 8 capsule expression contain the type-specific genes flanked by common genes. Microbiology (Reading). 1997 Jul; 143 ( Pt 7):2395-2405.
journal title abbreviation: Microbiology (Reading)
publication date: 1997-07-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1343139
type: Authorship
author rank in publication: 12
linked author: Lee, Jean
linked information resource: IBT-V02: A Multicomponent Toxoid Vaccine Protects Against Primary and Secondary Skin Infections Caused by Staphylococcus aureus.

IBT-V02: A Multicomponent Toxoid Vaccine Protects Against Primary and Secondary Skin Infections Caused by Staphylococcus aureus.
PubMed Identifier: 33777005
author list: Karauzum H, Venkatasubramaniam A, Adhikari RP, Kort T, Holtsberg FW, Mukherjee I, Mednikov M, Ortines R, Nguyen NTQ, Doan TMN, Diep BA, Lee JC, Aman MJ
published in: Frontiers in immunology
information resource reference: IBT-V02: A Multicomponent Toxoid Vaccine Protects Against Primary and Secondary Skin Infections Caused by Staphylococcus aureus. Front Immunol. 2021; 12:624310.
journal title abbreviation: Front Immunol
publication date: 2021-03-10T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1410236
type: Authorship
author rank in publication: 5
linked author: Lee, Jean
linked information resource: A functional menadione biosynthesis pathway is required for capsule production by Staphylococcus aureus.

A functional menadione biosynthesis pathway is required for capsule production by Staphylococcus aureus.
PubMed Identifier: 34825882
author list: Altwiley D, Brignoli T, Edwards A, Recker M, Lee JC, Massey RC
published in: Microbiology (Reading, England)
information resource reference: A functional menadione biosynthesis pathway is required for capsule production by Staphylococcus aureus. Microbiology (Reading). 2021 11; 167(11).
journal title abbreviation: Microbiology (Reading)
publication date: 2021-11-01T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1505526
type: Authorship
author rank in publication: 7
linked author: Lee, Jean
linked information resource: GltS regulates biofilm formation in methicillin-resistant Staphylococcus aureus.

GltS regulates biofilm formation in methicillin-resistant Staphylococcus aureus.
PubMed Identifier: 36418899
author list: Shibamura-Fujiogi M, Wang X, Maisat W, Koutsogiannaki S, Li Y, Chen Y, Lee JC, Yuki K
published in: Communications biology
information resource reference: GltS regulates biofilm formation in methicillin-resistant Staphylococcus aureus. Commun Biol. 2022 11 23; 5(1):1284.
journal title abbreviation: Commun Biol
publication date: 2022-11-23T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Member of the Affiliated Faculty of Health Sciences and Technology
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position in department: PME
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
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HR job title: Member of the Affiliated Faculty of Health Sciences and Technology
position in organization: Massachusetts Institute of Technology

Authorship 1525596
type: Authorship
author rank in publication: 3
linked author: Lee, Jean
linked information resource: Contribution of Extracellular Membrane Vesicles To the Secretome of Staphylococcus aureus.

Contribution of Extracellular Membrane Vesicles To the Secretome of Staphylococcus aureus.
PubMed Identifier: 36744901
author list: Uppu DS, Wang X, Lee JC
published in: mBio
information resource reference: Contribution of Extracellular Membrane Vesicles To the Secretome of Staphylococcus aureus. mBio. 2023 02 28; 14(1):e0357122.
journal title abbreviation: mBio
publication date: 2023-02-06T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
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Authorship 173151
type: Authorship
author rank in publication: 12
linked author: Lee, Jean
linked information resource: Immunization with Staphylococcus aureus clumping factor B, a major determinant in nasal carriage, reduces nasal colonization in a murine model.

Authorship 1553298
type: Authorship
author rank in publication: 6
linked author: Lee, Jean
linked information resource: Staphylococcus aureus Delta Toxin Modulates both Extracellular Membrane Vesicle Biogenesis and Amyloid Formation.

On-person adaptive evolution of Staphylococcus aureus during treatment for atopic dermatitis.
PubMed Identifier: 37054679
author list: Key FM, Khadka VD, Romo-González C, Blake KJ, Deng L, Lynn TC, Lee JC, Chiu IM, García-Romero MT, Lieberman TD
published in: Cell host & microbe
information resource reference: On-person adaptive evolution of Staphylococcus aureus during treatment for atopic dermatitis. Cell Host Microbe. 2023 04 12; 31(4):593-603.e7.
journal title abbreviation: Cell Host Microbe
publication date: 2023-04-12T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Staphylococcus aureus Delta Toxin Modulates both Extracellular Membrane Vesicle Biogenesis and Amyloid Formation.
PubMed Identifier: 36993475
author list: Wang X, Uppu DS, Dickey SW, Burgin DJ, Otto M, Lee JC
published in: bioRxiv : the preprint server for biology
information resource reference: Staphylococcus aureus Delta Toxin Modulates both Extracellular Membrane Vesicle Biogenesis and Amyloid Formation. bioRxiv. 2023 Mar 23.
journal title abbreviation: bioRxiv
publication date: 2023-03-23T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Staphylococcus aureus delta toxin modulates both extracellular membrane vesicle biogenesis and amyloid formation.
PubMed Identifier: 37795985
author list: Wang X, Uppu DS, Dickey SW, Burgin DJ, Otto M, Lee JC
published in: mBio
information resource reference: Staphylococcus aureus delta toxin modulates both extracellular membrane vesicle biogenesis and amyloid formation. mBio. 2023 10 31; 14(5):e0174823.
journal title abbreviation: mBio
publication date: 2023-10-05T00:00:00
year: 2023
type: Academic Article
type: Article
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type: Information Resource

Authorship 1594149
type: Authorship
author rank in publication: 6
linked author: Lee, Jean
linked information resource: Staphylococcus aureus delta toxin modulates both extracellular membrane vesicle biogenesis and amyloid formation.

Lecturer on Health Care Policy, Part-time
is primary position: true
position in department: Health Care Policy
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Lecturer on Health Care Policy, Part-time
position in organization: Harvard Medical School

Authorship 457738
type: Authorship
author rank in publication: 3
linked author: Lee, Jean
linked information resource: NorB, an efflux pump in Staphylococcus aureus strain MW2, contributes to bacterial fitness in abscesses.

Authorship 1652037
type: Authorship
author rank in publication: 2
linked author: Lee, Jean
linked information resource: Staphylococcus aureus membrane vesicles: an evolving story.

Staphylococcus aureus membrane vesicles: an evolving story.
PubMed Identifier: 38677977
author list: Wang X, Lee JC
published in: Trends in microbiology
information resource reference: Staphylococcus aureus membrane vesicles: an evolving story. Trends Microbiol. 2024 11; 32(11):1096-1105.
journal title abbreviation: Trends Microbiol
publication date: 2024-04-26T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Assistant Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Infectious Disease
sort order: 1
type: Position
HR job title: Assistant Professor of Medicine
position in organization: Brigham and Women's Hospital

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Infectious Disease
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Massachusetts General Hospital

Sir William Osler Professor of Ophthalmology
is primary position: true
position in department: Ophthalmology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Sir William Osler Professor of Ophthalmology
position in organization: Massachusetts Eye and Ear Infirmary

Associate Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Infectious Disease
sort order: 1
type: Position
HR job title: Associate Professor of Medicine
position in organization: Brigham and Women's Hospital

Authorship 44250
type: Authorship
author rank in publication: 8
linked author: Lee, Jean
linked information resource: CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections.

Research Fellow in Medicine
is primary position: true
position in department: Medicine
position in division: Infectious Disease
sort order: 1
type: Position
HR job title: Research Fellow in Medicine
position in organization: Massachusetts General Hospital

Authorship 73436
type: Authorship
author rank in publication: 6
linked author: Lee, Jean
linked information resource: Structural and biological characterization of a capsular polysaccharide produced by Staphylococcus haemolyticus.

Authorship 1724598
type: Authorship
author rank in publication: 5
linked author: Lee, Jean
linked information resource: Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid.

Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid.
PubMed Identifier: 39850879
author list: Hymøller KM, Christiansen SH, Schlosser AG, Skov Sørensen UB, Lee JC, Thiel S
published in: Frontiers in immunology
information resource reference: Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid. Front Immunol. 2024; 15:1504886.
journal title abbreviation: Front Immunol
publication date: 2025-01-07T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 683142
type: Authorship
author rank in publication: 4
linked author: Lee, Jean
linked information resource: Reduced neutrophil apoptosis in diabetic mice during staphylococcal infection leads to prolonged Tnfa production and reduced neutrophil clearance.

Authorship 685629
type: Authorship
author rank in publication: 3
linked author: Lee, Jean
linked information resource: Opsonic and protective properties of antibodies raised to conjugate vaccines targeting six Staphylococcus aureus antigens.

Authorship 686847
type: Authorship
author rank in publication: 7
linked author: Lee, Jean
linked information resource: The effectiveness of the controlled release of gentamicin from polyelectrolyte multilayers in the treatment of Staphylococcus aureus infection in a rabbit bone model.

Authorship 684951
type: Authorship
author rank in publication: 7
linked author: Lee, Jean
linked information resource: Characterization of the structure and biological functions of a capsular polysaccharide produced by Staphylococcus saprophyticus.

Authorship 685287
type: Authorship
author rank in publication: 10
linked author: Lee, Jean
linked information resource: Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice.

Authorship 685502
type: Authorship
author rank in publication: 3
linked author: Lee, Jean
linked information resource: Staphylococcus aureus NorD, a putative efflux pump coregulated with the Opp1 oligopeptide permease, contributes selectively to fitness in vivo.

Authorship 684830
type: Authorship
author rank in publication: 3
linked author: Lee, Jean
linked information resource: The zwitterionic cell wall teichoic acid of Staphylococcus aureus provokes skin abscesses in mice by a novel CD4+ T-cell-dependent mechanism.

Authorship 688537
type: Authorship
author rank in publication: 6
linked author: Lee, Jean
linked information resource: Production of capsular polysaccharide does not influence Staphylococcus aureus vancomycin susceptibility.

Authorship 689270
type: Authorship
author rank in publication: 8
linked author: Lee, Jean
linked information resource: Novel synthetic (poly)glycerolphosphate-based antistaphylococcal conjugate vaccine.

The zwitterionic cell wall teichoic acid of Staphylococcus aureus provokes skin abscesses in mice by a novel CD4+ T-cell-dependent mechanism.
PubMed Identifier: 20949105
author list: Weidenmaier C, McLoughlin RM, Lee JC
published in: PloS one
information resource reference: The zwitterionic cell wall teichoic acid of Staphylococcus aureus provokes skin abscesses in mice by a novel CD4+ T-cell-dependent mechanism. PLoS One. 2010 Oct 07; 5(10):e13227.
journal title abbreviation: PLoS One
publication date: 2010-10-07T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Novel synthetic (poly)glycerolphosphate-based antistaphylococcal conjugate vaccine.
PubMed Identifier: 23649092
author list: Chen Q, Dintaman J, Lees A, Sen G, Schwartz D, Shirtliff ME, Park S, Lee JC, Mond JJ, Snapper CM
published in: Infection and immunity
information resource reference: Novel synthetic (poly)glycerolphosphate-based antistaphylococcal conjugate vaccine. Infect Immun. 2013 Jul; 81(7):2554-61.
journal title abbreviation: Infect Immun
publication date: 2013-05-06T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Reduced neutrophil apoptosis in diabetic mice during staphylococcal infection leads to prolonged Tnfa production and reduced neutrophil clearance.
PubMed Identifier: 21912601
author list: Hanses F, Park S, Rich J, Lee JC
published in: PloS one
information resource reference: Reduced neutrophil apoptosis in diabetic mice during staphylococcal infection leads to prolonged Tnfa production and reduced neutrophil clearance. PLoS One. 2011; 6(8):e23633.
journal title abbreviation: PLoS One
publication date: 2011-08-30T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Production of capsular polysaccharide does not influence Staphylococcus aureus vancomycin susceptibility.
PubMed Identifier: 23522028
author list: Jansen A, Szekat C, Schröder W, Wolz C, Goerke C, Lee JC, Türck M, Bierbaum G
published in: BMC microbiology
information resource reference: Production of capsular polysaccharide does not influence Staphylococcus aureus vancomycin susceptibility. BMC Microbiol. 2013 Mar 22; 13:65.
journal title abbreviation: BMC Microbiol
publication date: 2013-03-22T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1730560
type: Authorship
author rank in publication: 5
linked author: Lee, Jean
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/279586906

https://connects.catalyst.harvard.edu/Profiles/profile/279586906
PubMed Identifier: 40007536
author list: Hymøller KM, Christiansen SH, Schlosser AG, Skov Sørensen UB, Lee JC, Thiel S
published in: Frontiers in immunology
information resource reference: Corrigendum: Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid. Front Immunol. 2025; 16:1568032.
journal title abbreviation: Front Immunol
publication date: 2025-02-11T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource
label: Corrigendum: Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid.

Authorship 698231
type: Authorship
author rank in publication: 6
linked author: Lee, Jean
linked information resource: Protein antigens increase the protective efficacy of a capsule-based vaccine against Staphylococcus aureus in a rat model of osteomyelitis.

Protein antigens increase the protective efficacy of a capsule-based vaccine against Staphylococcus aureus in a rat model of osteomyelitis.
PubMed Identifier: 24126523
author list: Lattar SM, Noto Llana M, Denoël P, Germain S, Buzzola FR, Lee JC, Sordelli DO
published in: Infection and immunity
information resource reference: Protein antigens increase the protective efficacy of a capsule-based vaccine against Staphylococcus aureus in a rat model of osteomyelitis. Infect Immun. 2014 Jan; 82(1):83-91.
journal title abbreviation: Infect Immun
publication date: 2013-10-14T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Corresponding Member of the Faculty of Medicine
is primary position: true
position in department: Medicine
position in division: Infectious Disease
sort order: 1
type: Position
HR job title: Corresponding Member of the Faculty of Medicine
position in organization: Brigham and Women's Hospital

Authorship 728210
type: Authorship
author rank in publication: 16
linked author: Lee, Jean
linked information resource: Prevention of Staphylococcus aureus infections by glycoprotein vaccines synthesized in Escherichia coli.

Prevention of Staphylococcus aureus infections by glycoprotein vaccines synthesized in Escherichia coli.
PubMed Identifier: 24308931
author list: Wacker M, Wang L, Kowarik M, Dowd M, Lipowsky G, Faridmoayer A, Shields K, Park S, Alaimo C, Kelley KA, Braun M, Quebatte J, Gambillara V, Carranza P, Steffen M, Lee JC
published in: The Journal of infectious diseases
information resource reference: Prevention of Staphylococcus aureus infections by glycoprotein vaccines synthesized in Escherichia coli. J Infect Dis. 2014 May 15; 209(10):1551-61.
journal title abbreviation: J Infect Dis
publication date: 2013-12-05T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 365870
type: Authorship
author rank in publication: 5
linked author: Lee, Jean
linked information resource: Capsule-negative Staphylococcus aureus induces chronic experimental mastitis in mice.

Authorship 1772121
type: Authorship
author rank in publication: 1
linked author: Lee, Jean
linked information resource: Protective efficacy of antibodies to the Staphylococcus aureus type 5 capsular polysaccharide in a modified model of endocarditis in rats.

Authorship 1772545
type: Authorship
author rank in publication: 7
linked author: Lee, Jean
linked information resource: On-person adaptive evolution of Staphylococcus aureus during treatment for atopic dermatitis.

Authorship 1785777
type: Authorship
author rank in publication: 1
linked author: Lee, Jean
linked information resource: An experimental vaccine that targets staphylococcal virulence.

Authorship 1787452
type: Authorship
author rank in publication: 5
linked author: Lee, Jean
linked information resource: Rapid Detection of Bacteria from Blood with Surface-Enhanced Raman Spectroscopy.

Authorship 1787647
type: Authorship
author rank in publication: 4
linked author: Lee, Jean
linked information resource: Rapid phenotypic stress-based microfluidic antibiotic susceptibility testing of Gram-negative clinical isolates.

Authorship 1798129
type: Authorship
author rank in publication: 2
linked author: Lee, Jean
linked information resource: The biochemical origins of the surface-enhanced Raman spectra of bacteria: a metabolomics profiling by SERS.

Authorship 1799719
type: Authorship
author rank in publication: 2
linked author: Lee, Jean
linked information resource: Optimization of Stress-Based Microfluidic Testing for Methicillin Resistance in Staphylococcusaureus Strains.

Authorship 1849420
type: Authorship
author rank in publication: 6
linked author: Lee, Jean
linked information resource: Scaffold vaccination for prevention of orthopedic device infection.

An experimental vaccine that targets staphylococcal virulence.
PubMed Identifier: 10036720
author list: Lee JC
published in: Trends in microbiology
information resource reference: An experimental vaccine that targets staphylococcal virulence. Trends Microbiol. 1998 Dec; 6(12):461-3.
journal title abbreviation: Trends Microbiol
publication date: 1998-12-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Rapid Detection of Bacteria from Blood with Surface-Enhanced Raman Spectroscopy.
PubMed Identifier: 27429301
author list: Boardman AK, Wong WS, Premasiri WR, Ziegler LD, Lee JC, Miljkovic M, Klapperich CM, Sharon A, Sauer-Budge AF
published in: Analytical chemistry
information resource reference: Rapid Detection of Bacteria from Blood with Surface-Enhanced Raman Spectroscopy. Anal Chem. 2016 08 16; 88(16):8026-35.
journal title abbreviation: Anal Chem
publication date: 2016-08-02T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

The biochemical origins of the surface-enhanced Raman spectra of bacteria: a metabolomics profiling by SERS.
PubMed Identifier: 27100230
author list: Premasiri WR, Lee JC, Sauer-Budge A, Théberge R, Costello CE, Ziegler LD
published in: Analytical and bioanalytical chemistry
information resource reference: The biochemical origins of the surface-enhanced Raman spectra of bacteria: a metabolomics profiling by SERS. Anal Bioanal Chem. 2016 Jul; 408(17):4631-47.
journal title abbreviation: Anal Bioanal Chem
publication date: 2016-04-21T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Optimization of Stress-Based Microfluidic Testing for Methicillin Resistance in Staphylococcusaureus Strains.
PubMed Identifier: 29673157
author list: Kalashnikov M, Lee JC, Sauer-Budge AF
published in: Diagnostics (Basel, Switzerland)
information resource reference: Optimization of Stress-Based Microfluidic Testing for Methicillin Resistance in Staphylococcusaureus Strains. Diagnostics (Basel). 2018 Apr 17; 8(2).
journal title abbreviation: Diagnostics (Basel)
publication date: 2018-04-17T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Rapid phenotypic stress-based microfluidic antibiotic susceptibility testing of Gram-negative clinical isolates.
PubMed Identifier: 28808348
author list: Kalashnikov M, Mueller M, McBeth C, Lee JC, Campbell J, Sharon A, Sauer-Budge AF
published in: Scientific reports
information resource reference: Rapid phenotypic stress-based microfluidic antibiotic susceptibility testing of Gram-negative clinical isolates. Sci Rep. 2017 08 14; 7(1):8031.
journal title abbreviation: Sci Rep
publication date: 2017-08-14T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Scaffold vaccination for prevention of orthopedic device infection.
PubMed Identifier: 41183185
author list: Tatara AM, Lightbown S, Kang S, Jung WH, Ijaz H, Lee JC, Nelson SB, Super M, Mooney DJ
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Scaffold vaccination for prevention of orthopedic device infection. Proc Natl Acad Sci U S A. 2025 Nov 11; 122(45):e2409562122.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2025-11-03T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Senior Lecturer on Population Medicine, Part-time
is primary position: true
position in department: Population Medicine
position in division: Infectious Disease
sort order: 1
type: Position
HR job title: Senior Lecturer on Population Medicine, Part-time
position in organization: Harvard Pilgrim Healthcare

Professor of Anaesthesia
is primary position: true
position in department: Anaesthesia
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Anaesthesia
position in organization: Boston Children's Hospital

Authorship 769112
type: Authorship
author rank in publication: 3
linked author: Lee, Jean
linked information resource: Antibodies to Staphylococcus aureus serotype 8 capsular polysaccharide react with and protect against serotype 5 and 8 isolates.

Authorship 769048
type: Authorship
author rank in publication: 5
linked author: Lee, Jean
linked information resource: Staphylococcus aureus gene expression in a rat model of infective endocarditis.

Staphylococcus aureus gene expression in a rat model of infective endocarditis.
PubMed Identifier: 25392717
author list: Hanses F, Roux C, Dunman PM, Salzberger B, Lee JC
published in: Genome medicine
information resource reference: Staphylococcus aureus gene expression in a rat model of infective endocarditis. Genome Med. 2014; 6(10):93.
journal title abbreviation: Genome Med
publication date: 2014-11-03T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Antibodies to Staphylococcus aureus serotype 8 capsular polysaccharide react with and protect against serotype 5 and 8 isolates.
PubMed Identifier: 25245803
author list: Park S, Gerber S, Lee JC
published in: Infection and immunity
information resource reference: Antibodies to Staphylococcus aureus serotype 8 capsular polysaccharide react with and protect against serotype 5 and 8 isolates. Infect Immun. 2014 Dec; 82(12):5049-55.
journal title abbreviation: Infect Immun
publication date: 2014-09-22T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 772035
type: Authorship
author rank in publication: 6
linked author: Lee, Jean
linked information resource: Analysis of the Staphylococcus aureus capsule biosynthesis pathway in vitro: characterization of the UDP-GlcNAc C6 dehydratases CapD and CapE and identification of enzyme inhibitors.

Analysis of the Staphylococcus aureus capsule biosynthesis pathway in vitro: characterization of the UDP-GlcNAc C6 dehydratases CapD and CapE and identification of enzyme inhibitors.
PubMed Identifier: 25023075
author list: Li W, Ulm H, Rausch M, Li X, O'Riordan K, Lee JC, Schneider T, Müller CE
published in: International journal of medical microbiology : IJMM
information resource reference: Analysis of the Staphylococcus aureus capsule biosynthesis pathway in vitro: characterization of the UDP-GlcNAc C6 dehydratases CapD and CapE and identification of enzyme inhibitors. Int J Med Microbiol. 2014 Nov; 304(8):958-69.
journal title abbreviation: Int J Med Microbiol
publication date: 2014-06-06T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 432917
type: Authorship
author rank in publication: 5
linked author: Lee, Jean
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/787471

Authorship 436364
type: Authorship
author rank in publication: 2
linked author: Lee, Jean
linked information resource: The pathogenesis of Staphylococcus aureus infection in the diabetic NOD mouse.

Authorship 334712
type: Authorship
author rank in publication: 2
linked author: Lee, Jean
linked information resource: Staphylococcus aureus capsular polysaccharides.

Authorship 365344
type: Authorship
author rank in publication: 2
linked author: Lee, Jean
linked information resource: IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection.

Authorship 217515
type: Authorship
author rank in publication: 4
linked author: Lee, Jean
linked information resource: Comparison of virulence in community-associated methicillin-resistant Staphylococcus aureus pulsotypes USA300 and USA400 in a rat model of pneumonia.

Authorship 27442
type: Authorship
author rank in publication: 4
linked author: Lee, Jean
linked information resource: Defects in innate immunity predispose C57BL/6J-Leprdb/Leprdb mice to infection by Staphylococcus aureus.

Authorship 523108
type: Authorship
author rank in publication: 6
linked author: Lee, Jean
linked information resource: Molecular characterization of the capsule locus from non-typeable Staphylococcus aureus.

Authorship 788676
type: Authorship
author rank in publication: 15
linked author: Lee, Jean
linked information resource: USA300 and USA500 clonal lineages of Staphylococcus aureus do not produce a capsular polysaccharide due to conserved mutations in the cap5 locus.

Authorship 798991
type: Authorship
author rank in publication: 6
linked author: Lee, Jean
linked information resource: Extended Staphylococcus aureus persistence in cystic fibrosis is associated with bacterial adaptation.

USA300 and USA500 clonal lineages of Staphylococcus aureus do not produce a capsular polysaccharide due to conserved mutations in the cap5 locus.
PubMed Identifier: 25852165
author list: Boyle-Vavra S, Li X, Alam MT, Read TD, Sieth J, Cywes-Bentley C, Dobbins G, David MZ, Kumar N, Eells SJ, Miller LG, Boxrud DJ, Chambers HF, Lynfield R, Lee JC, Daum RS
published in: mBio
information resource reference: USA300 and USA500 clonal lineages of Staphylococcus aureus do not produce a capsular polysaccharide due to conserved mutations in the cap5 locus. mBio. 2015 Apr 07; 6(2).
journal title abbreviation: mBio
publication date: 2015-04-07T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Extended Staphylococcus aureus persistence in cystic fibrosis is associated with bacterial adaptation.
PubMed Identifier: 24183484
author list: Hirschhausen N, Block D, Bianconi I, Bragonzi A, Birtel J, Lee JC, Dübbers A, Küster P, Kahl J, Peters G, Kahl BC
published in: International journal of medical microbiology : IJMM
information resource reference: Extended Staphylococcus aureus persistence in cystic fibrosis is associated with bacterial adaptation. Int J Med Microbiol. 2013 Dec; 303(8):685-92.
journal title abbreviation: Int J Med Microbiol
publication date: 2013-10-08T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 465981
type: Authorship
author rank in publication: 2
linked author: Lee, Jean
linked information resource: Staphylococcal vaccines and immunotherapies.

Authorship 819208
type: Authorship
author rank in publication: 8
linked author: Lee, Jean
linked information resource: Staphylococcus aureus Colonization of the Mouse Gastrointestinal Tract Is Modulated by Wall Teichoic Acid, Capsule, and Surface Proteins.

Staphylococcus aureus Colonization of the Mouse Gastrointestinal Tract Is Modulated by Wall Teichoic Acid, Capsule, and Surface Proteins.
PubMed Identifier: 26201029
author list: Misawa Y, Kelley KA, Wang X, Wang L, Park WB, Birtel J, Saslowsky D, Lee JC
published in: PLoS pathogens
information resource reference: Staphylococcus aureus Colonization of the Mouse Gastrointestinal Tract Is Modulated by Wall Teichoic Acid, Capsule, and Surface Proteins. PLoS Pathog. 2015 Jul; 11(7):e1005061.
journal title abbreviation: PLoS Pathog
publication date: 2015-07-22T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 533801
type: Authorship
author rank in publication: 4
linked author: Lee, Jean
linked information resource: Antibodies to capsular polysaccharide and clumping factor A prevent mastitis and the emergence of unencapsulated and small-colony variants of Staphylococcus aureus in mice.

Authorship 860791
type: Authorship
author rank in publication: 5
linked author: Lee, Jean
linked information resource: Phenotypic heterogeneity and temporal expression of the capsular polysaccharide in Staphylococcus aureus.

Phenotypic heterogeneity and temporal expression of the capsular polysaccharide in Staphylococcus aureus.
PubMed Identifier: 26303846
author list: George SE, Nguyen T, Geiger T, Weidenmaier C, Lee JC, Liese J, Wolz C
published in: Molecular microbiology
information resource reference: Phenotypic heterogeneity and temporal expression of the capsular polysaccharide in Staphylococcus aureus. Mol Microbiol. 2015 Dec; 98(6):1073-88.
journal title abbreviation: Mol Microbiol
publication date: 2015-09-25T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 868757
type: Authorship
author rank in publication: 6
linked author: Lee, Jean
linked information resource: Preclinical Efficacy of Clumping Factor A in Prevention of Staphylococcus aureus Infection.

Preclinical Efficacy of Clumping Factor A in Prevention of Staphylococcus aureus Infection.
PubMed Identifier: 26838725
author list: Li X, Wang X, Thompson CD, Park S, Park WB, Lee JC
published in: mBio
information resource reference: Preclinical Efficacy of Clumping Factor A in Prevention of Staphylococcus aureus Infection. mBio. 2016 Feb 02; 7(1):e02232-15.
journal title abbreviation: mBio
publication date: 2016-02-02T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 875704
type: Authorship
author rank in publication: 4
linked author: Lee, Jean
linked information resource: Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion.

Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion.
PubMed Identifier: 26864627
author list: Saslowsky DE, Thiagarajah JR, McCormick BA, Lee JC, Lencer WI
published in: Molecular biology of the cell
information resource reference: Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion. Mol Biol Cell. 2016 Apr 01; 27(7):1120-30.
journal title abbreviation: Mol Biol Cell
publication date: 2016-02-10T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 876711
type: Authorship
author rank in publication: 2
linked author: Lee, Jean
linked information resource: Murine Models of Bacteremia and Surgical Wound Infection for the Evaluation of Staphylococcus aureus Vaccine Candidates.

Murine Models of Bacteremia and Surgical Wound Infection for the Evaluation of Staphylococcus aureus Vaccine Candidates.
PubMed Identifier: 27076144
author list: Wang L, Lee JC
published in: Methods in molecular biology (Clifton, N.J.)
information resource reference: Murine Models of Bacteremia and Surgical Wound Infection for the Evaluation of Staphylococcus aureus Vaccine Candidates. Methods Mol Biol. 2016; 1403:409-18.
journal title abbreviation: Methods Mol Biol
publication date: 2016-01-01T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 446244
type: Authorship
author rank in publication: 2
linked author: Lee, Jean
linked information resource: Vaccination and passive immunisation against Staphylococcus aureus.

Authorship 530403
type: Authorship
author rank in publication: 6
linked author: Lee, Jean
linked information resource: Staphylococcus aureus strains that express serotype 5 or serotype 8 capsular polysaccharides differ in virulence.

Assistant Professor
sort order: 2
type: Faculty Rank

Associate Professor
sort order: 1
type: Faculty Rank

Fellow or Post Doc
sort order: 6
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Instructor
sort order: 4
type: Faculty Rank

Lecturer
sort order: 3
type: Faculty Rank

Other Faculty
sort order: 5
type: Faculty Rank

Authorship 61903
type: Authorship
author rank in publication: 13
linked author: Lee, Jean
linked information resource: Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species.

Authorship 896234
type: Authorship
author rank in publication: 6
linked author: Lee, Jean
linked information resource: The Staphylococcus aureus polysaccharide capsule and Efb-dependent fibrinogen shield act in concert to protect against phagocytosis.

The Staphylococcus aureus polysaccharide capsule and Efb-dependent fibrinogen shield act in concert to protect against phagocytosis.
PubMed Identifier: 27112346
author list: Kuipers A, Stapels DAC, Weerwind LT, Ko YP, Ruyken M, Lee JC, van Kessel KPM, Rooijakkers SHM
published in: Microbiology (Reading, England)
information resource reference: The Staphylococcus aureus polysaccharide capsule and Efb-dependent fibrinogen shield act in concert to protect against phagocytosis. Microbiology (Reading). 2016 07; 162(7):1185-1194.
journal title abbreviation: Microbiology (Reading)
publication date: 2016-04-25T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

A New Approach to Staphylococcus aureus Vaccine Development - Resubmission 01
end date: 2018-07-31
principal investigator name: DAUM, ROBERT S.
start date: 2013-08-01
type: Grant
sponsor award id: R01AI103342

NASAL COLONIZATION BY S AUREUS--MECHANISMS AND IMMUNITY
end date: 2004-11-30
principal investigator name: LEE, JEAN CLAIRE
start date: 1998-12-01
type: Grant
sponsor award id: R01AI044136

STAPHYLOCOCCUS AUREUS: CAPSULAR ANTIGENS AND IMMUNITY
end date: 1995-07-31
principal investigator name: LEE, JEAN CLAIRE
start date: 1985-07-01
type: Grant
sponsor award id: R01AI023244

2005 Staphylococcal Diseases Gordon Research Conferences
end date: 2006-05-31
principal investigator name: LEE, JEAN CLAIRE
start date: 2005-06-01
type: Grant
sponsor award id: R13AI066878

Genetic Analysis of S. aureus Capsule Production
end date: 2007-03-31
principal investigator name: LEE, JEAN CLAIRE
start date: 1989-12-01
type: Grant
sponsor award id: R01AI029040

ROLE OF STAPHYLOCOCCUS AUREUS CAPSULES IN PATHOGENESIS
end date: 1987-06-30
principal investigator name: LEE, JEAN CLAIRE
start date: 1985-07-01
type: Grant
sponsor award id: R23AI023244

Novel Bioconjugate Vaccines to Prevent Staphylococcus aureus Infection
end date: 2016-03-31
principal investigator name: LEE, JEAN CLAIRE
start date: 2010-04-01
type: Grant
sponsor award id: R01AI088754

GENETIC ANALYSIS OF S. AUREUS CAPSULE PRODUCTION
end date: 2001-09-29
principal investigator name: LEE, JEAN CLAIRE
start date: 1989-12-01
type: Grant
sponsor award id: R21AI029040

Biological relevance of capsule expression by S. aureus
end date: 2007-03-31
principal investigator name: LEE, JEAN CLAIRE
start date: 2003-04-01
type: Grant
sponsor award id: R03TW006264

Principal Investigator
type: Researcher Role
researcher role of: Lee, Jean
contributes to: Novel Bioconjugate Vaccines to Prevent Staphylococcus aureus Infection

Principal Investigator
type: Researcher Role
researcher role of: Lee, Jean
contributes to: Biological relevance of capsule expression by S. aureus

Principal Investigator
type: Researcher Role
researcher role of: Lee, Jean
contributes to: Genetic Analysis of S. aureus Capsule Production

Principal Investigator
type: Researcher Role
researcher role of: Lee, Jean
contributes to: NASAL COLONIZATION BY S AUREUS--MECHANISMS AND IMMUNITY

Principal Investigator
type: Researcher Role
researcher role of: Lee, Jean
contributes to: ROLE OF STAPHYLOCOCCUS AUREUS CAPSULES IN PATHOGENESIS

Principal Investigator
type: Researcher Role
researcher role of: Lee, Jean
contributes to: GENETIC ANALYSIS OF S. AUREUS CAPSULE PRODUCTION

Principal Investigator
type: Researcher Role
researcher role of: Lee, Jean
contributes to: 2005 Staphylococcal Diseases Gordon Research Conferences

Principal Investigator
type: Researcher Role
researcher role of: Lee, Jean
contributes to: STAPHYLOCOCCUS AUREUS: CAPSULAR ANTIGENS AND IMMUNITY

Co-Principal Investigator
type: Researcher Role
researcher role of: Lee, Jean
contributes to: A New Approach to Staphylococcus aureus Vaccine Development - Resubmission 01

Authorship 913458
type: Authorship
author rank in publication: 10
linked author: Lee, Jean
linked information resource: Evolutionarily distinct bacteriophage endolysins featuring conserved peptidoglycan cleavage sites protect mice from MRSA infection.

Evolutionarily distinct bacteriophage endolysins featuring conserved peptidoglycan cleavage sites protect mice from MRSA infection.
PubMed Identifier: 25630640
author list: Schmelcher M, Shen Y, Nelson DC, Eugster MR, Eichenseher F, Hanke DC, Loessner MJ, Dong S, Pritchard DG, Lee JC, Becker SC, Foster-Frey J, Donovan DM
published in: The Journal of antimicrobial chemotherapy
information resource reference: Evolutionarily distinct bacteriophage endolysins featuring conserved peptidoglycan cleavage sites protect mice from MRSA infection. J Antimicrob Chemother. 2015 May; 70(5):1453-65.
journal title abbreviation: J Antimicrob Chemother
publication date: 2015-01-27T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 60713
type: Authorship
author rank in publication: 5
linked author: Lee, Jean
linked information resource: Capsular polysaccharide masks clumping factor A-mediated adherence of Staphylococcus aureus to fibrinogen and platelets.

Authorship 340996
type: Authorship
author rank in publication: 2
linked author: Lee, Jean
linked information resource: Intrafamilial outbreak of subcutaneous abscesses caused by PVL-positive methicillin-sensitive Staphylococcus aureus.

Authorship 933281
type: Authorship
author rank in publication: 2
linked author: Lee, Jean
linked information resource: Structure and Function of Surface Polysaccharides of Staphylococcus aureus.

Authorship 934684
type: Authorship
author rank in publication: 4
linked author: Lee, Jean
linked information resource: Protective efficacy of a novel alpha hemolysin subunit vaccine (AT62) against Staphylococcus aureus skin and soft tissue infections.

Structure and Function of Surface Polysaccharides of Staphylococcus aureus.
PubMed Identifier: 26728067
author list: Weidenmaier C, Lee JC
published in: Current topics in microbiology and immunology
information resource reference: Structure and Function of Surface Polysaccharides of Staphylococcus aureus. Curr Top Microbiol Immunol. 2017; 409:57-93.
journal title abbreviation: Curr Top Microbiol Immunol
publication date: 2017-01-01T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Protective efficacy of a novel alpha hemolysin subunit vaccine (AT62) against Staphylococcus aureus skin and soft tissue infections.
PubMed Identifier: 27847174
author list: Adhikari RP, Thompson CD, Aman MJ, Lee JC
published in: Vaccine
information resource reference: Protective efficacy of a novel alpha hemolysin subunit vaccine (AT62) against Staphylococcus aureus skin and soft tissue infections. Vaccine. 2016 12 07; 34(50):6402-6407.
journal title abbreviation: Vaccine
publication date: 2016-11-12T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 383270
type: Authorship
author rank in publication: 4
linked author: Lee, Jean
linked information resource: Regulation of Staphylococcus aureus capsular polysaccharide expression by agr and sarA.

Authorship 942872
type: Authorship
author rank in publication: 10
linked author: Lee, Jean
linked information resource: Dynamic in vivo mutations within the ica operon during persistence of Staphylococcus aureus in the airways of cystic fibrosis patients.

Authorship 942795
type: Authorship
author rank in publication: 5
linked author: Lee, Jean
linked information resource: Antibodies to Staphylococcus aureus capsular polysaccharides 5 and 8 perform similarly in vitro but are functionally distinct in vivo.

Dynamic in vivo mutations within the ica operon during persistence of Staphylococcus aureus in the airways of cystic fibrosis patients.
PubMed Identifier: 27902784
author list: Schwartbeck B, Birtel J, Treffon J, Langhanki L, Mellmann A, Kale D, Kahl J, Hirschhausen N, Neumann C, Lee JC, Götz F, Rohde H, Henke H, Küster P, Peters G, Kahl BC
published in: PLoS pathogens
information resource reference: Dynamic in vivo mutations within the ica operon during persistence of Staphylococcus aureus in the airways of cystic fibrosis patients. PLoS Pathog. 2016 Nov; 12(11):e1006024.
journal title abbreviation: PLoS Pathog
publication date: 2016-11-30T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Antibodies to Staphylococcus aureus capsular polysaccharides 5 and 8 perform similarly in vitro but are functionally distinct in vivo.
PubMed Identifier: 27936346
author list: Liu B, Park S, Thompson CD, Li X, Lee JC
published in: Virulence
information resource reference: Antibodies to Staphylococcus aureus capsular polysaccharides 5 and 8 perform similarly in vitro but are functionally distinct in vivo. Virulence. 2017 08 18; 8(6):859-874.
journal title abbreviation: Virulence
publication date: 2016-12-09T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of Staphylococcus aureus capsular polysaccharide expression by agr and sarA.
PubMed Identifier: 11796569
author list: Luong T, Sau S, Gomez M, Lee JC, Lee CY
published in: Infection and immunity
information resource reference: Regulation of Staphylococcus aureus capsular polysaccharide expression by agr and sarA. Infect Immun. 2002 Feb; 70(2):444-50.
journal title abbreviation: Infect Immun
publication date: 2002-02-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 962044
type: Authorship
author rank in publication: 1
linked author: Lee, Jean
linked information resource: Development of Antistaphylococcal Vaccines.

Development of Antistaphylococcal Vaccines.
PubMed Identifier: 11722808
author list: Lee JC
published in: Current infectious disease reports
information resource reference: Development of Antistaphylococcal Vaccines. Curr Infect Dis Rep. 2001 Dec; 3(6):517-524.
journal title abbreviation: Curr Infect Dis Rep
publication date: 2001-12-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 978280
type: Authorship
author rank in publication: 5
linked author: Lee, Jean
linked information resource: Evaluation of serotypes 5 and 8 capsular polysaccharides in protection against Staphylococcus aureus in murine models of infection.

Evaluation of serotypes 5 and 8 capsular polysaccharides in protection against Staphylococcus aureus in murine models of infection.
PubMed Identifier: 28422567
author list: Cheng BL, Nielsen TB, Pantapalangkoor P, Zhao F, Lee JC, Montgomery CP, Luna B, Spellberg B, Daum RS
published in: Human vaccines & immunotherapeutics
information resource reference: Evaluation of serotypes 5 and 8 capsular polysaccharides in protection against Staphylococcus aureus in murine models of infection. Hum Vaccin Immunother. 2017 07 03; 13(7):1609-1614.
journal title abbreviation: Hum Vaccin Immunother
publication date: 2017-04-19T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

https://connects.catalyst.harvard.edu/Profiles/profile/787471
PubMed Identifier: 12464616
author list: Kneidinger B, O'Riordan K, Li J, Brisson JR, Lee JC, Lam JS
published in: The Journal of biological chemistry
information resource reference: Three highly conserved proteins catalyze the conversion of UDP-N-acetyl-D-glucosamine to precursors for the biosynthesis of O antigen in Pseudomonas aeruginosa O11 and capsule in Staphylococcus aureus type 5. Implications for the UDP-N-acetyl-L-fucosamine biosynthetic pathway. J Biol Chem. 2003 Feb 07; 278(6):3615-27.
journal title abbreviation: J Biol Chem
publication date: 2002-12-02T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource
label: Three highly conserved proteins catalyze the conversion of UDP-N-acetyl-D-glucosamine to precursors for the biosynthesis of O antigen in Pseudomonas aeruginosa O11 and capsule in Staphylococcus aureus type 5. Implications for the UDP-N-acetyl-L-fucosamine biosynthetic pathway.

Staphylococcus aureus strains that express serotype 5 or serotype 8 capsular polysaccharides differ in virulence.
PubMed Identifier: 15908379
author list: Watts A, Ke D, Wang Q, Pillay A, Nicholson-Weller A, Lee JC
published in: Infection and immunity
information resource reference: Staphylococcus aureus strains that express serotype 5 or serotype 8 capsular polysaccharides differ in virulence. Infect Immun. 2005 Jun; 73(6):3502-11.
journal title abbreviation: Infect Immun
publication date: 2005-06-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

181 Longwood Ave
type: Address
address line 1: Infectious Diseases
address line 3: 181 Longwood Ave
city: Boston
postal code: 02115
state or province: MA

Staphylococcus aureus NorD, a putative efflux pump coregulated with the Opp1 oligopeptide permease, contributes selectively to fitness in vivo.
PubMed Identifier: 23042988
author list: Ding Y, Fu Y, Lee JC, Hooper DC
published in: Journal of bacteriology
information resource reference: Staphylococcus aureus NorD, a putative efflux pump coregulated with the Opp1 oligopeptide permease, contributes selectively to fitness in vivo. J Bacteriol. 2012 Dec; 194(23):6586-93.
journal title abbreviation: J Bacteriol
publication date: 2012-10-05T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Staphylococcal vaccines and immunotherapies.
PubMed Identifier: 19135920
author list: Schaffer AC, Lee JC
published in: Infectious disease clinics of North America
information resource reference: Staphylococcal vaccines and immunotherapies. Infect Dis Clin North Am. 2009 Mar; 23(1):153-71.
journal title abbreviation: Infect Dis Clin North Am
publication date: 2009-03-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species.
PubMed Identifier: 16237012
author list: Takeuchi F, Watanabe S, Baba T, Yuzawa H, Ito T, Morimoto Y, Kuroda M, Cui L, Takahashi M, Ankai A, Baba S, Fukui S, Lee JC, Hiramatsu K
published in: Journal of bacteriology
information resource reference: Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species. J Bacteriol. 2005 Nov; 187(21):7292-308.
journal title abbreviation: J Bacteriol
publication date: 2005-11-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

The pathogenesis of Staphylococcus aureus infection in the diabetic NOD mouse.
PubMed Identifier: 16186391
author list: Rich J, Lee JC
published in: Diabetes
information resource reference: The pathogenesis of Staphylococcus aureus infection in the diabetic NOD mouse. Diabetes. 2005 Oct; 54(10):2904-10.
journal title abbreviation: Diabetes
publication date: 2005-10-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Staphylococcus aureus capsular polysaccharides.
PubMed Identifier: 14726462
author list: O'Riordan K, Lee JC
published in: Clinical microbiology reviews
information resource reference: Staphylococcus aureus capsular polysaccharides. Clin Microbiol Rev. 2004 Jan; 17(1):218-34.
journal title abbreviation: Clin Microbiol Rev
publication date: 2004-01-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection.
PubMed Identifier: 18606687
author list: McLoughlin RM, Lee JC, Kasper DL, Tzianabos AO
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: IFN-gamma regulated chemokine production determines the outcome of Staphylococcus aureus infection. J Immunol. 2008 Jul 15; 181(2):1323-32.
journal title abbreviation: J Immunol
publication date: 2008-07-15T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Intrafamilial outbreak of subcutaneous abscesses caused by PVL-positive methicillin-sensitive Staphylococcus aureus.
PubMed Identifier: 18678412
author list: Kalka-Moll WM, Lee JC, Fabri M, Seifert H
published in: The Journal of infection
information resource reference: Intrafamilial outbreak of subcutaneous abscesses caused by PVL-positive methicillin-sensitive Staphylococcus aureus. J Infect. 2008 Sep; 57(3):278-80.
journal title abbreviation: J Infect
publication date: 2008-08-03T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Characterization of the structure and biological functions of a capsular polysaccharide produced by Staphylococcus saprophyticus.
PubMed Identifier: 20639341
author list: Park S, Kelley KA, Vinogradov E, Solinga R, Weidenmaier C, Misawa Y, Lee JC
published in: Journal of bacteriology
information resource reference: Characterization of the structure and biological functions of a capsular polysaccharide produced by Staphylococcus saprophyticus. J Bacteriol. 2010 Sep; 192(18):4618-26.
journal title abbreviation: J Bacteriol
publication date: 2010-07-16T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular characterization of the capsule locus from non-typeable Staphylococcus aureus.
PubMed Identifier: 16420363
author list: Cocchiaro JL, Gomez MI, Risley A, Solinga R, Sordelli DO, Lee JC
published in: Molecular microbiology
information resource reference: Molecular characterization of the capsule locus from non-typeable Staphylococcus aureus. Mol Microbiol. 2006 Feb; 59(3):948-60.
journal title abbreviation: Mol Microbiol
publication date: 2006-02-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Protective efficacy of antibodies to the Staphylococcus aureus type 5 capsular polysaccharide in a modified model of endocarditis in rats.
PubMed Identifier: 9317020
author list: Lee JC, Park JS, Shepherd SE, Carey V, Fattom A
published in: Infection and immunity
information resource reference: Protective efficacy of antibodies to the Staphylococcus aureus type 5 capsular polysaccharide in a modified model of endocarditis in rats. Infect Immun. 1997 Oct; 65(10):4146-51.
journal title abbreviation: Infect Immun
publication date: 1997-10-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Structural and biological characterization of a capsular polysaccharide produced by Staphylococcus haemolyticus.
PubMed Identifier: 18165309
author list: Flahaut S, Vinogradov E, Kelley KA, Brennan S, Hiramatsu K, Lee JC
published in: Journal of bacteriology
information resource reference: Structural and biological characterization of a capsular polysaccharide produced by Staphylococcus haemolyticus. J Bacteriol. 2008 Mar; 190(5):1649-57.
journal title abbreviation: J Bacteriol
publication date: 2007-12-28T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Antibodies to capsular polysaccharide and clumping factor A prevent mastitis and the emergence of unencapsulated and small-colony variants of Staphylococcus aureus in mice.
PubMed Identifier: 18809660
author list: Tuchscherr LP, Buzzola FR, Alvarez LP, Lee JC, Sordelli DO
published in: Infection and immunity
information resource reference: Antibodies to capsular polysaccharide and clumping factor A prevent mastitis and the emergence of unencapsulated and small-colony variants of Staphylococcus aureus in mice. Infect Immun. 2008 Dec; 76(12):5738-44.
journal title abbreviation: Infect Immun
publication date: 2008-09-22T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Capsular polysaccharide masks clumping factor A-mediated adherence of Staphylococcus aureus to fibrinogen and platelets.
PubMed Identifier: 17703424
author list: Risley AL, Loughman A, Cywes-Bentley C, Foster TJ, Lee JC
published in: The Journal of infectious diseases
information resource reference: Capsular polysaccharide masks clumping factor A-mediated adherence of Staphylococcus aureus to fibrinogen and platelets. J Infect Dis. 2007 Sep 15; 196(6):919-27.
journal title abbreviation: J Infect Dis
publication date: 2007-08-10T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Immunization with Staphylococcus aureus clumping factor B, a major determinant in nasal carriage, reduces nasal colonization in a murine model.
PubMed Identifier: 16552044
author list: Schaffer AC, Solinga RM, Cocchiaro J, Portoles M, Kiser KB, Risley A, Randall SM, Valtulina V, Speziale P, Walsh E, Foster T, Lee JC
published in: Infection and immunity
information resource reference: Immunization with Staphylococcus aureus clumping factor B, a major determinant in nasal carriage, reduces nasal colonization in a murine model. Infect Immun. 2006 Apr; 74(4):2145-53.
journal title abbreviation: Infect Immun
publication date: 2006-04-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Opsonic and protective properties of antibodies raised to conjugate vaccines targeting six Staphylococcus aureus antigens.
PubMed Identifier: 23077517
author list: Pozzi C, Wilk K, Lee JC, Gening M, Nifantiev N, Pier GB
published in: PloS one
information resource reference: Opsonic and protective properties of antibodies raised to conjugate vaccines targeting six Staphylococcus aureus antigens. PLoS One. 2012; 7(10):e46648.
journal title abbreviation: PLoS One
publication date: 2012-10-15T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource