Kochupurakkal, Bose
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last name: Kochupurakkal
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full name: Bose S Kochupurakkal, Ph.D.
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education and training: St. Joseph's College, Chemistry, Microbiology, Botany
education and training: National Institute of Technology, Applied Chemistry
education and training: Weizmann Institute of Science, Molecular Cell Biology
education and training: Dana-Farber Cancer Institute/Harvard Medical School, Breast Cancer/Pathology
research areas: Ovarian Neoplasms
research areas: Pyrazines
research areas: Transcription Factor RelA
research areas: Streptothricins
research areas: Interferons
mailing address: 450 Brookline Ave
middle name or initial: S
ORCID id: 0000-0001-8929-3070

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Nanog inhibits the switch of myogenic cells towards the osteogenic lineage.
PubMed Identifier: 18039466
author list: Kochupurakkal BS, Sarig R, Fuchs O, Piestun D, Rechavi G, Givol D
published in: Biochemical and biophysical research communications
information resource reference: Nanog inhibits the switch of myogenic cells towards the osteogenic lineage. Biochem Biophys Res Commun. 2008 Jan 25; 365(4):846-50.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 2007-11-26T00:00:00
year: 2007
type: Academic Article
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Authorship 1093184
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author rank in publication: 13
linked author: Kochupurakkal, Bose
linked information resource: Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids.

Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids.
PubMed Identifier: 30213835
author list: Hill SJ, Decker B, Roberts EA, Horowitz NS, Muto MG, Worley MJ, Feltmate CM, Nucci MR, Swisher EM, Nguyen H, Yang C, Morizane R, Kochupurakkal BS, Do KT, Konstantinopoulos PA, Liu JF, Bonventre JV, Matulonis UA, Shapiro GI, Berkowitz RS, Crum CP, D'Andrea AD
published in: Cancer discovery
information resource reference: Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids. Cancer Discov. 2018 11; 8(11):1404-1421.
journal title abbreviation: Cancer Discov
publication date: 2018-09-13T00:00:00
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The achilles heel of ErbB-2/HER2: regulation by the Hsp90 chaperone machine and potential for pharmacological intervention.
PubMed Identifier: 14657666
author list: Citri A, Kochupurakkal BS, Yarden Y
published in: Cell cycle (Georgetown, Tex.)
information resource reference: The achilles heel of ErbB-2/HER2: regulation by the Hsp90 chaperone machine and potential for pharmacological intervention. Cell Cycle. 2004 Jan; 3(1):51-60.
journal title abbreviation: Cell Cycle
publication date: 2004-01-01T00:00:00
year: 2004
type: Academic Article
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Signaling by growth factor receptors.
PubMed Identifier: 14755089
author list: Kochupurakkal BS, Yarden Y
published in: Methods in molecular biology (Clifton, N.J.)
information resource reference: Signaling by growth factor receptors. Methods Mol Biol. 2004; 250:177-202.
journal title abbreviation: Methods Mol Biol
publication date: 2004-01-01T00:00:00
year: 2004
type: Academic Article
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Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling.
PubMed Identifier: 17486068
author list: Shtiegman K, Kochupurakkal BS, Zwang Y, Pines G, Starr A, Vexler A, Citri A, Katz M, Lavi S, Ben-Basat Y, Benjamin S, Corso S, Gan J, Yosef RB, Giordano S, Yarden Y
published in: Oncogene
information resource reference: Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling. Oncogene. 2007 Oct 25; 26(49):6968-78.
journal title abbreviation: Oncogene
publication date: 2007-05-07T00:00:00
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type: Academic Article
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Authorship 1139616
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linked information resource: Olaparib and a-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial.

Olaparib and a-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial.
PubMed Identifier: 30880072
author list: Konstantinopoulos PA, Barry WT, Birrer M, Westin SN, Cadoo KA, Shapiro GI, Mayer EL, O'Cearbhaill RE, Coleman RL, Kochupurakkal B, Whalen C, Curtis J, Farooq S, Luo W, Eismann J, Buss MK, Aghajanian C, Mills GB, Palakurthi S, Kirschmeier P, Liu J, Cantley LC, Kaufmann SH, Swisher EM, D'Andrea AD, Winer E, Wulf GM, Matulonis UA
published in: The Lancet. Oncology
information resource reference: Olaparib and a-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial. Lancet Oncol. 2019 04; 20(4):570-580.
journal title abbreviation: Lancet Oncol
publication date: 2019-03-14T00:00:00
year: 2019
type: Academic Article
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Transcription Factor RelA
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number of authors: 192
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Pyrazines
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Interferons
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Streptothricins
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Ovarian Neoplasms
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Konstantinopoulos, Panagiotis
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Shapiro, Geoffrey
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McCleary, Nadine
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Jackman, David M
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Iglehart, James
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D'Andrea, Alan
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Hodi, Frank
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Authorship 1183637
type: Authorship
author rank in publication: 2
linked author: Kochupurakkal, Bose
linked information resource: The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP Inhibition.

The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP Inhibition.
PubMed Identifier: 31409614
author list: Parmar K, Kochupurakkal BS, Lazaro JB, Wang ZC, Palakurthi S, Kirschmeier PT, Yang C, Sambel LA, Färkkilä A, Reznichenko E, Reavis HD, Dunn CE, Zou L, Do KT, Konstantinopoulos PA, Matulonis UA, Liu JF, D'Andrea AD, Shapiro GI
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP Inhibition. Clin Cancer Res. 2019 10 15; 25(20):6127-6140.
journal title abbreviation: Clin Cancer Res
publication date: 2019-08-13T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1189824
type: Authorship
author rank in publication: 10
linked author: Kochupurakkal, Bose
linked information resource: Functional profiling of nucleotide Excision repair in breast cancer.

Functional profiling of nucleotide Excision repair in breast cancer.
PubMed Identifier: 31499327
author list: Rajkumar-Calkins AS, Szalat R, Dreze M, Khan I, Frazier Z, Reznichenkov E, Schnorenberg MR, Tsai YF, Nguyen H, Kochupurakkal B, D'Andrea AD, Shapiro GI, Lazaro JB, Mouw KW
published in: DNA repair
information resource reference: Functional profiling of nucleotide Excision repair in breast cancer. DNA Repair (Amst). 2019 10; 82:102697.
journal title abbreviation: DNA Repair (Amst)
publication date: 2019-08-30T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1204397
type: Authorship
author rank in publication: 4
linked author: Kochupurakkal, Bose
linked information resource: Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia.

Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia.
PubMed Identifier: 31721781
author list: Pouliot GP, Degar J, Hinze L, Kochupurakkal B, Vo CD, Burns MA, Moreau L, Ganesa C, Roderick J, Peirs S, Menten B, Loh ML, Hunger SP, Silverman LB, Harris MH, Stevenson KE, Weinstock DM, Weng AP, Van Vlierberghe P, D'Andrea AD, Gutierrez A
published in: PloS one
information resource reference: Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia. PLoS One. 2019; 14(11):e0221288.
journal title abbreviation: PLoS One
publication date: 2019-11-13T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Professor of Medicine
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position in division: Adult Oncology
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position in organization: Dana-Farber Cancer Institute

Assistant Professor of Medicine
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position in division: Oncology
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HR job title: Assistant Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Authorship 1227067
type: Authorship
author rank in publication: 4
linked author: Kochupurakkal, Bose
linked information resource: Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection.

Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection.
PubMed Identifier: 32075772
author list: Cai MY, Dunn CE, Chen W, Kochupurakkal BS, Nguyen H, Moreau LA, Shapiro GI, Parmar K, Kozono D, D'Andrea AD
published in: Cell reports
information resource reference: Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection. Cell Rep. 2020 02 18; 30(7):2402-2415.e5.
journal title abbreviation: Cell Rep
publication date: 2020-02-18T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1231383
type: Authorship
author rank in publication: 6
linked author: Kochupurakkal, Bose
linked information resource: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer.

Authorship 1231879
type: Authorship
author rank in publication: 8
linked author: Kochupurakkal, Bose
linked information resource: ATM Loss Confers Greater Sensitivity to ATR Inhibition Than PARP Inhibition in Prostate Cancer.

ATM Loss Confers Greater Sensitivity to ATR Inhibition Than PARP Inhibition in Prostate Cancer.
PubMed Identifier: 32127357
author list: Rafiei S, Fitzpatrick K, Liu D, Cai MY, Elmarakeby HA, Park J, Ricker C, Kochupurakkal BS, Choudhury AD, Hahn WC, Balk SP, Hwang JH, Van Allen EM, Mouw KW
published in: Cancer research
information resource reference: ATM Loss Confers Greater Sensitivity to ATR Inhibition Than PARP Inhibition in Prostate Cancer. Cancer Res. 2020 06 01; 80(11):2094-2100.
journal title abbreviation: Cancer Res
publication date: 2020-03-03T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer.
PubMed Identifier: 32193378
author list: Färkkilä A, Gulhan DC, Casado J, Jacobson CA, Nguyen H, Kochupurakkal B, Maliga Z, Yapp C, Chen YA, Schapiro D, Zhou Y, Graham JR, Dezube BJ, Munster P, Santagata S, Garcia E, Rodig S, Lako A, Chowdhury D, Shapiro GI, Matulonis UA, Park PJ, Hautaniemi S, Sorger PK, Swisher EM, D'Andrea AD, Konstantinopoulos PA
published in: Nature communications
information resource reference: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer. Nat Commun. 2020 03 19; 11(1):1459.
journal title abbreviation: Nat Commun
publication date: 2020-03-19T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1237308
type: Authorship
author rank in publication: 3
linked author: Kochupurakkal, Bose
linked information resource: Reversion and non-reversion mechanisms of resistance to PARP inhibitor or platinum chemotherapy in BRCA1/2-mutant metastatic breast cancer.

Reversion and non-reversion mechanisms of resistance to PARP inhibitor or platinum chemotherapy in BRCA1/2-mutant metastatic breast cancer.
PubMed Identifier: 32245699
author list: Waks AG, Cohen O, Kochupurakkal B, Kim D, Dunn CE, Buendia Buendia J, Wander S, Helvie K, Lloyd MR, Marini L, Hughes ME, Freeman SS, Ivy SP, Geradts J, Isakoff S, LoRusso P, Adalsteinsson VA, Tolaney SM, Matulonis U, Krop IE, D'Andrea AD, Winer EP, Lin NU, Shapiro GI, Wagle N
published in: Annals of oncology : official journal of the European Society for Medical Oncology
information resource reference: Reversion and non-reversion mechanisms of resistance to PARP inhibitor or platinum chemotherapy in BRCA1/2-mutant metastatic breast cancer. Ann Oncol. 2020 05; 31(5):590-598.
journal title abbreviation: Ann Oncol
publication date: 2020-02-20T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1248478
type: Authorship
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linked author: Kochupurakkal, Bose
linked information resource: Author Correction: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer.

Author Correction: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer.
PubMed Identifier: 32424117
author list: Färkkilä A, Gulhan DC, Casado J, Jacobson CA, Nguyen H, Kochupurakkal B, Maliga Z, Yapp C, Chen YA, Schapiro D, Zhou Y, Graham JR, Dezube BJ, Munster P, Santagata S, Garcia E, Rodig S, Lako A, Chowdhury D, Shapiro GI, Matulonis UA, Park PJ, Hautaniemi S, Sorger PK, Swisher EM, D'Andrea AD, Konstantinopoulos PA
published in: Nature communications
information resource reference: Author Correction: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer. Nat Commun. 2020 05 18; 11(1):2543.
journal title abbreviation: Nat Commun
publication date: 2020-05-18T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Clinical Efficacy and Molecular Response Correlates of the WEE1 Inhibitor Adavosertib Combined with Cisplatin in Patients with Metastatic Triple-Negative Breast Cancer.
PubMed Identifier: 33257427
author list: Keenan TE, Li T, Vallius T, Guerriero JL, Tayob N, Kochupurakkal B, Davis J, Pastorello R, Tahara RK, Anderson L, Conway J, He MX, Shannon E, Godin RE, Sorger PK, D'Andrea A, Overmoyer B, Winer EP, Mittendorf EA, Van Allen EM, Shapiro GI, Tolaney SM
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Clinical Efficacy and Molecular Response Correlates of the WEE1 Inhibitor Adavosertib Combined with Cisplatin in Patients with Metastatic Triple-Negative Breast Cancer. Clin Cancer Res. 2021 02 15; 27(4):983-991.
journal title abbreviation: Clin Cancer Res
publication date: 2020-11-30T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1310469
type: Authorship
author rank in publication: 6
linked author: Kochupurakkal, Bose
linked information resource: Clinical Efficacy and Molecular Response Correlates of the WEE1 Inhibitor Adavosertib Combined with Cisplatin in Patients with Metastatic Triple-Negative Breast Cancer.

Authorship 1364671
type: Authorship
author rank in publication: 2
linked author: Kochupurakkal, Bose
linked information resource: Phase 1 Combination Study of the CHK1 Inhibitor Prexasertib and the PARP Inhibitor Olaparib in High-grade Serous Ovarian Cancer and Other Solid Tumors.

Phase 1 Combination Study of the CHK1 Inhibitor Prexasertib and the PARP Inhibitor Olaparib in High-grade Serous Ovarian Cancer and Other Solid Tumors.
PubMed Identifier: 34131002
author list: Do KT, Kochupurakkal B, Kelland S, de Jonge A, Hedglin J, Powers A, Quinn N, Gannon C, Vuong L, Parmar K, Lazaro JB, D'Andrea AD, Shapiro GI
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Phase 1 Combination Study of the CHK1 Inhibitor Prexasertib and the PARP Inhibitor Olaparib in High-grade Serous Ovarian Cancer and Other Solid Tumors. Clin Cancer Res. 2021 09 01; 27(17):4710-4716.
journal title abbreviation: Clin Cancer Res
publication date: 2021-06-15T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.
PubMed Identifier: 34179826
author list: Zhou J, Gelot C, Pantelidou C, Li A, Yücel H, Davis RE, Färkkilä A, Kochupurakkal B, Syed A, Shapiro GI, Tainer JA, Blagg BSJ, Ceccaldi R, D'Andrea AD
published in: Nature cancer
information resource reference: A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors. Nat Cancer. 2021 06; 2(6):598-610.
journal title abbreviation: Nat Cancer
publication date: 2021-06-17T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1370275
type: Authorship
author rank in publication: 8
linked author: Kochupurakkal, Bose
linked information resource: A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.

Authorship 1396679
type: Authorship
author rank in publication: 7
linked author: Kochupurakkal, Bose
linked information resource: A Replication stress biomarker is associated with response to gemcitabine versus combined gemcitabine and ATR inhibitor therapy in ovarian cancer.

A Replication stress biomarker is associated with response to gemcitabine versus combined gemcitabine and ATR inhibitor therapy in ovarian cancer.
PubMed Identifier: 34552099
author list: Konstantinopoulos PA, da Costa AABA, Gulhan D, Lee EK, Cheng SC, Hendrickson AEW, Kochupurakkal B, Kolin DL, Kohn EC, Liu JF, Stover EH, Curtis J, Tayob N, Polak M, Chowdhury D, Matulonis UA, Färkkilä A, D'Andrea AD, Shapiro GI
published in: Nature communications
information resource reference: A Replication stress biomarker is associated with response to gemcitabine versus combined gemcitabine and ATR inhibitor therapy in ovarian cancer. Nat Commun. 2021 09 22; 12(1):5574.
journal title abbreviation: Nat Commun
publication date: 2021-09-22T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

A Phase I Study of Combination Olaparib and Radium-223 in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) with Bone Metastases (COMRADE).
PubMed Identifier: 36780008
author list: Pan E, Xie W, Ajmera A, Araneta A, Jamieson C, Folefac E, Hussain A, Kyriakopoulos CE, Olson A, Parikh M, Parikh R, Saraiya B, Ivy SP, Van Allen EM, Lindeman NI, Kochupurakkal BS, Shapiro GI, McKay RR
published in: Molecular cancer therapeutics
information resource reference: A Phase I Study of Combination Olaparib and Radium-223 in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) with Bone Metastases (COMRADE). Mol Cancer Ther. 2023 04 03; 22(4):511-518.
journal title abbreviation: Mol Cancer Ther
publication date: 2023-04-03T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Phase II Study of Olaparib and Temozolomide for Advanced Uterine Leiomyosarcoma (NCI Protocol 10250).
PubMed Identifier: 37467452
author list: Ingham M, Allred JB, Chen L, Das B, Kochupurakkal B, Gano K, George S, Attia S, Burgess MA, Seetharam M, Boikos SA, Bui N, Chen JL, Close JL, Cote GM, Thaker PH, Ivy SP, Bose S, D'Andrea A, Marino-Enriquez A, Shapiro GI, Schwartz GK
published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
information resource reference: Phase II Study of Olaparib and Temozolomide for Advanced Uterine Leiomyosarcoma (NCI Protocol 10250). J Clin Oncol. 2023 09 01; 41(25):4154-4163.
journal title abbreviation: J Clin Oncol
publication date: 2023-07-19T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

A Phase I Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-dose Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma.
PubMed Identifier: 37819936
author list: Huffman BM, Feng H, Parmar K, Wang J, Kapner KS, Kochupurakkal B, Martignetti DB, Sadatrezaei G, Abrams TA, Biller LH, Giannakis M, Ng K, Patel AK, Perez KJ, Singh H, Rubinson DA, Schlechter BL, Andrews E, Hannigan AM, Dunwell S, Getchell Z, Raghavan S, Wolpin BM, Fortier C, D'Andrea AD, Aguirre AJ, Shapiro GI, Cleary JM
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: A Phase I Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-dose Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma. Clin Cancer Res. 2023 12 15; 29(24):5047-5056.
journal title abbreviation: Clin Cancer Res
publication date: 2023-12-15T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Associate Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Associate Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Alvan T. and Viola D. Fuller American Cancer Society Professor of Radiation Oncology
is primary position: true
position in department: Radiation Oncology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Alvan T. and Viola D. Fuller American Cancer Society Professor of Radiation Oncology
position in organization: Dana-Farber Cancer Institute

Randomized Phase II Study of Gemcitabine With or Without ATR Inhibitor Berzosertib in Platinum-Resistant Ovarian Cancer: Final Overall Survival and Biomarker Analyses.
PubMed Identifier: 38635934
author list: Konstantinopoulos PA, Cheng SC, Lee EK, da Costa AABA, Gulhan D, Wahner Hendrickson AE, Kochupurakkal B, Kolin DL, Kohn EC, Liu JF, Penson RT, Stover EH, Curtis J, Sawyer H, Polak M, Chowdhury D, D'Andrea AD, Färkkilä A, Shapiro GI, Matulonis UA
published in: JCO precision oncology
information resource reference: Randomized Phase II Study of Gemcitabine With or Without ATR Inhibitor Berzosertib in Platinum-Resistant Ovarian Cancer: Final Overall Survival and Biomarker Analyses. JCO Precis Oncol. 2024 Apr; 8:e2300635.
journal title abbreviation: JCO Precis Oncol
publication date: 2024-04-01T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Research Associate in Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Research Associate in Medicine
position in organization: Dana-Farber Cancer Institute

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Jerome and Nancy Kohlberg Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Jerome and Nancy Kohlberg Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Kraft Family Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Adult Oncology
sort order: 1
type: Position
HR job title: Kraft Family Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Authorship 654284
type: Authorship
author rank in publication: 1
linked author: Kochupurakkal, Bose
linked information resource: Nourseothricin N-acetyl transferase: a positive selection marker for mammalian cells.

Nourseothricin N-acetyl transferase: a positive selection marker for mammalian cells.
PubMed Identifier: 23861913
author list: Kochupurakkal BS, Iglehart JD
published in: PloS one
information resource reference: Nourseothricin N-acetyl transferase: a positive selection marker for mammalian cells. PLoS One. 2013; 8(7):e68509.
journal title abbreviation: PLoS One
publication date: 2013-07-04T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

A Translational Study of the ATR Inhibitor Berzosertib as Monotherapy in Four Molecularly Defined Cohorts of Advanced Solid Tumors.
PubMed Identifier: 39453756
author list: Cote GM, Kochupurakkal BS, Do K, Bullock A, Cheng ML, Muzikansky A, McLoughlin DE, Cleary JM, Gao X, Parikh A, Park JC, Weekes CD, Yeku O, Zou L, Shapiro GI
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: A Translational Study of the ATR Inhibitor Berzosertib as Monotherapy in Four Molecularly Defined Cohorts of Advanced Solid Tumors. Clin Cancer Res. 2025 Jan 06; 31(1):35-44.
journal title abbreviation: Clin Cancer Res
publication date: 2025-01-06T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

PARG inhibitor sensitivity correlates with accumulation of single-stranded DNA gaps in preclinical models of ovarian cancer.
PubMed Identifier: 39546575
author list: Ravindranathan R, Somuncu O, da Costa AABA, Mukkavalli S, Lamarre BP, Nguyen H, Grochala C, Jiao Y, Liu J, Kochupurakkal B, Parmar K, Shapiro GI, D'Andrea AD
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: PARG inhibitor sensitivity correlates with accumulation of single-stranded DNA gaps in preclinical models of ovarian cancer. Proc Natl Acad Sci U S A. 2024 Nov 19; 121(47):e2413954121.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2024-11-15T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Authorship 693980
type: Authorship
author rank in publication: 2
linked author: Kochupurakkal, Bose
linked information resource: Tumor mutation burden forecasts outcome in ovarian cancer with BRCA1 or BRCA2 mutations.

Tumor mutation burden forecasts outcome in ovarian cancer with BRCA1 or BRCA2 mutations.
PubMed Identifier: 24265793
author list: Birkbak NJ, Kochupurakkal B, Izarzugaza JM, Eklund AC, Li Y, Liu J, Szallasi Z, Matulonis UA, Richardson AL, Iglehart JD, Wang ZC
published in: PloS one
information resource reference: Tumor mutation burden forecasts outcome in ovarian cancer with BRCA1 or BRCA2 mutations. PLoS One. 2013; 8(11):e80023.
journal title abbreviation: PLoS One
publication date: 2013-11-12T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Anne E. Dyson Professor in Women's Cancers, Emeritus
is primary position: true
position in department: Emeritus
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Anne E. Dyson Professor in Women's Cancers, Emeritus
position in organization: Harvard Medical School

St. Joseph's College, Chemistry, Microbiology, Botany
end date: 1994
educational organization: St. Joseph's College
training location: Bangalore, India
type: EducationalTraining
degree earned: B.Sc.
major field of degree: Chemistry, Microbiology, Botany

National Institute of Technology, Applied Chemistry
end date: 1996
educational organization: National Institute of Technology
training location: Tiruchirappalli, India
type: EducationalTraining
degree earned: M.Sc.
major field of degree: Applied Chemistry

Weizmann Institute of Science, Molecular Cell Biology
end date: 2005
educational organization: Weizmann Institute of Science
training location: Rehovot, Israel
type: EducationalTraining
degree earned: Ph.D.
major field of degree: Molecular Cell Biology

Dana-Farber Cancer Institute/Harvard Medical School, Breast Cancer/Pathology
end date: 2015
educational organization: Dana-Farber Cancer Institute/Harvard Medical School
training location: Boston, MA
type: EducationalTraining
degree earned: Fellowship
major field of degree: Breast Cancer/Pathology

Authorship 1754259
type: Authorship
linked author: Kochupurakkal, Bose
linked information resource: The deaf and the dumb: the biology of ErbB-2 and ErbB-3.

Authorship 1754260
type: Authorship
author rank in publication: 7
linked author: Kochupurakkal, Bose
linked information resource: Randomized Phase II Study of Gemcitabine With or Without ATR Inhibitor Berzosertib in Platinum-Resistant Ovarian Cancer: Final Overall Survival and Biomarker Analyses.

Authorship 1754261
type: Authorship
author rank in publication: 2
linked author: Kochupurakkal, Bose
linked information resource: A Translational Study of the ATR Inhibitor Berzosertib as Monotherapy in Four Molecularly Defined Cohorts of Advanced Solid Tumors.

Authorship 1754262
type: Authorship
author rank in publication: 6
linked author: Kochupurakkal, Bose
linked information resource: A Phase I Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-dose Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma.

Authorship 1754263
type: Authorship
author rank in publication: 10
linked author: Kochupurakkal, Bose
linked information resource: PARG inhibitor sensitivity correlates with accumulation of single-stranded DNA gaps in preclinical models of ovarian cancer.

Authorship 1754264
type: Authorship
linked author: Kochupurakkal, Bose
linked information resource: Signal transduction and oncogenesis by ErbB/HER receptors.

Authorship 1754265
type: Authorship
author rank in publication: 5
linked author: Kochupurakkal, Bose
linked information resource: Phase II Study of Olaparib and Temozolomide for Advanced Uterine Leiomyosarcoma (NCI Protocol 10250).

Authorship 1754266
type: Authorship
author rank in publication: 16
linked author: Kochupurakkal, Bose
linked information resource: A Phase I Study of Combination Olaparib and Radium-223 in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) with Bone Metastases (COMRADE).

The deaf and the dumb: the biology of ErbB-2 and ErbB-3.
PubMed Identifier: 12648465
author list: Citri A, Skaria KB, Yarden Y
published in: Experimental cell research
information resource reference: The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp Cell Res. 2003 Mar 10; 284(1):54-65.
journal title abbreviation: Exp Cell Res
publication date: 2003-03-10T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Signal transduction and oncogenesis by ErbB/HER receptors.
PubMed Identifier: 14967450
author list: Marmor MD, Skaria KB, Yarden Y
published in: International journal of radiation oncology, biology, physics
information resource reference: Signal transduction and oncogenesis by ErbB/HER receptors. Int J Radiat Oncol Biol Phys. 2004 Mar 01; 58(3):903-13.
journal title abbreviation: Int J Radiat Oncol Biol Phys
publication date: 2004-03-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 205799
type: Authorship
author rank in publication: 2
linked author: Kochupurakkal, Bose
linked information resource: Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling.

Authorship 724091
type: Authorship
author rank in publication: 4
linked author: Kochupurakkal, Bose
linked information resource: NF-?B activation-induced anti-apoptosis renders HER2-positive cells drug resistant and accelerates tumor growth.

NF-?B activation-induced anti-apoptosis renders HER2-positive cells drug resistant and accelerates tumor growth.
PubMed Identifier: 24319068
author list: Bailey ST, Miron PL, Choi YJ, Kochupurakkal B, Maulik G, Rodig SJ, Tian R, Foley KM, Bowman T, Miron A, Brown M, Iglehart JD, Debajit KB
published in: Molecular cancer research : MCR
information resource reference: NF-?B activation-induced anti-apoptosis renders HER2-positive cells drug resistant and accelerates tumor growth. Mol Cancer Res. 2014 Mar; 12(3):408-420.
journal title abbreviation: Mol Cancer Res
publication date: 2013-12-06T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Associate Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Associate Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Authorship 367602
type: Authorship
author rank in publication: 7
linked author: Kochupurakkal, Bose
linked information resource: Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases.

Authorship 256131
type: Authorship
author rank in publication: 2
linked author: Kochupurakkal, Bose
linked information resource: The achilles heel of ErbB-2/HER2: regulation by the Hsp90 chaperone machine and potential for pharmacological intervention.

Authorship 552420
type: Authorship
author rank in publication: 1
linked author: Kochupurakkal, Bose
linked information resource: Nanog inhibits the switch of myogenic cells towards the osteogenic lineage.

Authorship 552658
type: Authorship
author rank in publication: 1
linked author: Kochupurakkal, Bose
linked information resource: Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity.

Authorship 840635
type: Authorship
author rank in publication: 1
linked author: Kochupurakkal, Bose
linked information resource: RelA-Induced Interferon Response Negatively Regulates Proliferation.

RelA-Induced Interferon Response Negatively Regulates Proliferation.
PubMed Identifier: 26460486
author list: Kochupurakkal BS, Wang ZC, Hua T, Culhane AC, Rodig SJ, Rajkovic-Molek K, Lazaro JB, Richardson AL, Biswas DK, Iglehart JD
published in: PloS one
information resource reference: RelA-Induced Interferon Response Negatively Regulates Proliferation. PLoS One. 2015; 10(10):e0140243.
journal title abbreviation: PLoS One
publication date: 2015-10-13T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 856470
type: Authorship
author rank in publication: 2
linked author: Kochupurakkal, Bose
linked information resource: Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer.

Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer.
PubMed Identifier: 26728511
author list: Chandler P, Kochupurakkal BS, Alam S, Richardson AL, Soybel DI, Kelleher SL
published in: Molecular cancer
information resource reference: Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer. Mol Cancer. 2016 Jan 05; 15:2.
journal title abbreviation: Mol Cancer
publication date: 2016-01-05T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 871846
type: Authorship
author rank in publication: 1
linked author: Kochupurakkal, Bose
linked information resource: Identification of genes responsible for RelA-dependent proliferation arrest in human mammary epithelial cells conditionally expressing RelA.

Identification of genes responsible for RelA-dependent proliferation arrest in human mammary epithelial cells conditionally expressing RelA.
PubMed Identifier: 26981373
author list: Kochupurakkal BS, Iglehart JD
published in: Genomics data
information resource reference: Identification of genes responsible for RelA-dependent proliferation arrest in human mammary epithelial cells conditionally expressing RelA. Genom Data. 2016 Mar; 7:92-3.
journal title abbreviation: Genom Data
publication date: 2015-11-27T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Assistant Professor
sort order: 2
type: Faculty Rank

Associate Professor
sort order: 1
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Other Faculty
sort order: 5
type: Faculty Rank

Authorship 97694
type: Authorship
author rank in publication: 2
linked author: Kochupurakkal, Bose
linked information resource: Nanog transforms NIH3T3 cells and targets cell-type restricted genes.

Authorship 937536
type: Authorship
author rank in publication: 12
linked author: Kochupurakkal, Bose
linked information resource: CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer.

CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer.
PubMed Identifier: 27880910
author list: Johnson SF, Cruz C, Greifenberg AK, Dust S, Stover DG, Chi D, Primack B, Cao S, Bernhardy AJ, Coulson R, Lazaro JB, Kochupurakkal B, Sun H, Unitt C, Moreau LA, Sarosiek KA, Scaltriti M, Juric D, Baselga J, Richardson AL, Rodig SJ, D'Andrea AD, Balmaña J, Johnson N, Geyer M, Serra V, Lim E, Shapiro GI
published in: Cell reports
information resource reference: CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer. Cell Rep. 2016 11 22; 17(9):2367-2381.
journal title abbreviation: Cell Rep
publication date: 2016-11-22T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 319035
type: Authorship
author rank in publication: 1
linked author: Kochupurakkal, Bose
linked information resource: Signaling by growth factor receptors.

Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases.
PubMed Identifier: 16735510
author list: Oved S, Mosesson Y, Zwang Y, Santonico E, Shtiegman K, Marmor MD, Kochupurakkal BS, Katz M, Lavi S, Cesareni G, Yarden Y
published in: The Journal of biological chemistry
information resource reference: Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases. J Biol Chem. 2006 Aug 04; 281(31):21640-21651.
journal title abbreviation: J Biol Chem
publication date: 2006-05-30T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity.
PubMed Identifier: 15611079
author list: Kochupurakkal BS, Harari D, Di-Segni A, Maik-Rachline G, Lyass L, Gur G, Kerber G, Citri A, Lavi S, Eilam R, Chalifa-Caspi V, Eshhar Z, Pikarsky E, Pinkas-Kramarski R, Bacus SS, Yarden Y
published in: The Journal of biological chemistry
information resource reference: Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity. J Biol Chem. 2005 Mar 04; 280(9):8503-12.
journal title abbreviation: J Biol Chem
publication date: 2004-12-17T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

450 Brookline Ave
type: Address
address line 1: Dana-Farber Cancer Institute
address line 2: Him 324
address line 3: 450 Brookline Ave
city: Boston
postal code: 02215
state or province: MA

Nanog transforms NIH3T3 cells and targets cell-type restricted genes.
PubMed Identifier: 16540082
author list: Piestun D, Kochupurakkal BS, Jacob-Hirsch J, Zeligson S, Koudritsky M, Domany E, Amariglio N, Rechavi G, Givol D
published in: Biochemical and biophysical research communications
information resource reference: Nanog transforms NIH3T3 cells and targets cell-type restricted genes. Biochem Biophys Res Commun. 2006 Apr 28; 343(1):279-85.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 2006-03-06T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource