Erdman S, Fox JG, Dangler CA, Feldman D, Horwitz BH
Journal of immunology (Baltimore, Md. : 1950)
Typhlocolitis in NF-kappa B-deficient mice. J Immunol. 2001 Feb 01; 166(3):1443-7.
Typhlocolitis in NF-kappa B-deficient mice.
Rao VP, Poutahidis T, Ge Z, Nambiar PR, Horwitz BH, Fox JG, Erdman SE
Proinflammatory CD4+ CD45RB(hi) lymphocytes promote mammary and intestinal carcinogenesis in Apc(Min/+) mice. Cancer Res. 2006 Jan 01; 66(1):57-61.
Proinflammatory CD4+ CD45RB(hi) lymphocytes promote mammary and intestinal carcinogenesis in Apc(Min/+) mice.
Biswas A, Shouval DS, Griffith A, Goettel JA, Field M, Kang YH, Konnikova L, Janssen E, Redhu NS, Thrasher AJ, Chatila T, Kuchroo VK, Geha RS, Notarangelo LD, Pai SY, Horwitz BH, Snapper SB
WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. Nat Commun. 2018 05 03; 9(1):1779.
WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis.
Poutahidis T, Haigis KM, Rao VP, Nambiar PR, Taylor CL, Ge Z, Watanabe K, Davidson A, Horwitz BH, Fox JG, Erdman SE
Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. Carcinogenesis. 2007 Dec; 28(12):2614-23.
Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma.
Prakash SS, Horwitz BH, Zibello T, Settleman J, DiMaio D
Bovine papillomavirus E2 gene regulates expression of the viral E5 transforming gene. J Virol. 1988 Oct; 62(10):3608-13.
Bovine papillomavirus E2 gene regulates expression of the viral E5 transforming gene.
Horwitz BH, Mizgerd JP, Scott ML, Doerschuk CM
Mechanisms of granulocytosis in the absence of CD18. Blood. 2001 Mar 15; 97(6):1578-83.
Mechanisms of granulocytosis in the absence of CD18.
Settleman J, Fazeli A, Malicki J, Horwitz BH, DiMaio D
Genetic evidence that acute morphologic transformation, induction of cellular DNA synthesis, and focus formation are mediated by a single activity of the bovine papillomavirus E5 protein. Mol Cell Biol. 1989 Dec; 9(12):5563-72.
Genetic evidence that acute morphologic transformation, induction of cellular DNA synthesis, and focus formation are mediated by a single activity of the bovine papillomavirus E5 protein.
Rao VP, Poutahidis T, Ge Z, Nambiar PR, Boussahmain C, Wang YY, Horwitz BH, Fox JG, Erdman SE
Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice. Cancer Res. 2006 Aug 01; 66(15):7395-400.
Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice.
The straw that stirs the drink: insight into the pathogenesis of inflammatory bowel disease revealed through the study of microflora-induced inflammation in genetically modified mice. Inflamm Bowel Dis. 2007 Apr; 13(4):490-500.
The straw that stirs the drink: insight into the pathogenesis of inflammatory bowel disease revealed through the study of microflora-induced inflammation in genetically modified mice.
Watanabe K, Rao VP, Poutahidis T, Rickman BH, Ohtani M, Xu S, Rogers AB, Ge Z, Horwitz BH, Fujioka T, Erdman SE, Fox JG
Cytotoxic-T-lymphocyte-associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis. Infect Immun. 2008 Dec; 76(12):5834-42.
Cytotoxic-T-lymphocyte-associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis.
Yang HT, Wang Y, Zhao X, Demissie E, Papoutsopoulou S, Mambole A, O'Garra A, Tomczak MF, Erdman SE, Fox JG, Ley SC, Horwitz BH
NF-?B1 inhibits TLR-induced IFN-ß production in macrophages through TPL-2-dependent ERK activation. J Immunol. 2011 Feb 15; 186(4):1989-96.
NF-?B1 inhibits TLR-induced IFN-ß production in macrophages through TPL-2-dependent ERK activation.
Nguyen DD, Wurbel MA, Goettel JA, Eston MA, Ahmed OS, Marin R, Boden EK, Villablanca EJ, Paidassi H, Ahuja V, Reinecker HC, Fiebiger E, Lacy-Hulbert A, Horwitz BH, Mora JR, Snapper SB
Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice. Gastroenterology. 2012 Sep; 143(3):719-729.e2.
Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice.
Ryzhakov G, West NR, Franchini F, Clare S, Ilott NE, Sansom SN, Bullers SJ, Pearson C, Costain A, Vaughan-Jackson A, Goettel JA, Ermann J, Horwitz BH, Buti L, Lu X, Mukhopadhyay S, Snapper SB, Powrie F
Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis. Nat Commun. 2018 09 18; 9(1):3797.
Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis.
Mizgerd JP, Horwitz BH, Quillen HC, Scott ML, Doerschuk CM
Effects of CD18 deficiency on the emigration of murine neutrophils during pneumonia. J Immunol. 1999 Jul 15; 163(2):995-9.
Effects of CD18 deficiency on the emigration of murine neutrophils during pneumonia.
Kurt J. Isselbacher Professor of Medicine in the Field of Gastroenterology
William Bosworth Castle Professor of Medicine
Venkatesh D, Ernandez T, Rosetti F, Batal I, Cullere X, Luscinskas FW, Zhang Y, Stavrakis G, García-Cardeña G, Horwitz BH, Mayadas TN
Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-ß autocrine signaling to promote monocyte recruitment. Immunity. 2013 May 23; 38(5):1025-37.
Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-ß autocrine signaling to promote monocyte recruitment.
Egan Family Foundation Professor of Pediatrics in the Field of Transitional Medicine
Samuel L. Wasserstrom Professor of Neurology
O'Hara JM, Redhu NS, Cheung E, Robertson NG, Patik I, Sayed SE, Thompson CM, Herd M, Lucas KB, Conaway E, Morton CC, Farber DL, Malley R, Horwitz BH
Generation of protective pneumococcal-specific nasal resident memory CD4+ T cells via parenteral immunization. Mucosal Immunol. 2020 01; 13(1):172-182.
Generation of protective pneumococcal-specific nasal resident memory CD4+ T cells via parenteral immunization.
Whary MT, Wang C, Ruff CF, DiVincenzo MJ, Labriola C, Ge L, Feng Y, Ge Z, Bakthavatchalu V, Muthupalani S, Horwitz BH, Fox JG
Effects of Colonization of Gnotobiotic Swiss Webster Mice with Helicobacter bilis. Comp Med. 2020 06 01; 70(3):216-232.
Effects of Colonization of Gnotobiotic Swiss Webster Mice with Helicobacter bilis.
Mitsialis V, Wall S, Liu P, Ordovas-Montanes J, Parmet T, Vukovic M, Spencer D, Field M, McCourt C, Toothaker J, Bousvaros A, Shalek AK, Kean L, Horwitz B, Goldsmith J, Tseng G, Snapper SB, Konnikova L
Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn's Disease. Gastroenterology. 2020 08; 159(2):591-608.e10.
Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn's Disease.
Cosgrove PR, Redhu NS, Tang Y, Monuteaux MC, Horwitz BH
Characterizing T cell subsets in the nasal mucosa of children with acute respiratory symptoms. Pediatr Res. 2021 11; 90(5):1023-1030.
Characterizing T cell subsets in the nasal mucosa of children with acute respiratory symptoms.
Ziegler CGK, Miao VN, Owings AH, Navia AW, Tang Y, Bromley JD, Lotfy P, Sloan M, Laird H, Williams HB, George M, Drake RS, Christian T, Parker A, Sindel CB, Burger MW, Pride Y, Hasan M, Abraham GE, Senitko M, Robinson TO, Shalek AK, Glover SC, Horwitz BH, Ordovas-Montanes J
bioRxiv : the preprint server for biology
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19. bioRxiv. 2021 Feb 20.
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19.
Marangell LB, Ketter TA, George MS, Pazzaglia PJ, Callahan AM, Parekh P, Andreason PJ, Horwitz B, Herscovitch P, Post RM
Inverse relationship of peripheral thyrotropin-stimulating hormone levels to brain activity in mood disorders. Am J Psychiatry. 1997 Feb; 154(2):224-30.
Inverse relationship of peripheral thyrotropin-stimulating hormone levels to brain activity in mood disorders.
George MS, Ketter TA, Parekh PI, Rosinsky N, Ring H, Casey BJ, Trimble MR, Horwitz B, Herscovitch P, Post RM
Regional brain activity when selecting a response despite interference: An H2 (15) O PET study of the stroop and an emotional stroop. Hum Brain Mapp. 1994; 1(3):194-209.
Regional brain activity when selecting a response despite interference: An H2 (15) O PET study of the stroop and an emotional stroop.
George MS, Ketter TA, Parekh PI, Horwitz B, Herscovitch P, Post RM
Brain activity during transient sadness and happiness in healthy women. Am J Psychiatry. 1995 Mar; 152(3):341-51.
Brain activity during transient sadness and happiness in healthy women.
Ouahed J, Kelsen JR, Spessott WA, Kooshesh K, Sanmillan ML, Dawany N, Sullivan KE, Hamilton KE, Slowik V, Nejentsev S, Neves JF, Flores H, Chung WK, Wilson A, Anyane-Yeboa K, Wou K, Jain P, Field M, Tollefson S, Dent MH, Li D, Naito T, McGovern DPB, Kwong AC, Taliaferro F, Ordovas-Montanes J, Horwitz BH, Kotlarz D, Klein C, Evans J, Dorsey J, Warner N, Elkadri A, Muise AM, Goldsmith J, Thompson B, Engelhardt KR, Cant AJ, Hambleton S, Barclay A, Toth-Petroczy A, Vuzman D, Carmichael N, Bodea C, Cassa CA, Devoto M, Maas RL, Behrens EM, Giraudo CG, Snapper SB
Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation. J Crohns Colitis. 2021 Nov 08; 15(11):1908-1919.
Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation.
Liu JJ, Sloan ME, Owings AH, Figgins E, Gauthier J, Gharaibeh R, Robinson T, Williams H, Sindel CB, Backus F, Ayyalasomayajula K, Parker A, Senitko M, Abraham GE, Claggett B, Horwitz BH, Jobin C, Adelman RM, Diamond G, Glover SC
The American journal of gastroenterology
Increased ACE2 Levels and Mortality Risk of Patients With COVID-19 on Proton Pump Inhibitor Therapy. Am J Gastroenterol. 2021 08 01; 116(8):1638-1645.
Increased ACE2 Levels and Mortality Risk of Patients With COVID-19 on Proton Pump Inhibitor Therapy.
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19. Cell. 2021 09 02; 184(18):4713-4733.e22.
Tsou AM, Goettel JA, Bao B, Biswas A, Kang YH, Redhu NS, Peng K, Putzel GG, Saltzman J, Kelly R, Gringauz J, Barends J, Hatazaki M, Frei SM, Emani R, Huang Y, Shen Z, Fox JG, Glickman JN, Horwitz BH, Snapper SB
Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation. Microbiome. 2021 11 03; 9(1):215.
Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation.
El Sayed S, Patik I, Redhu NS, Glickman JN, Karagiannis K, El Naenaeey ESY, Elmowalid GA, Abd El Wahab AM, Snapper SB, Horwitz BH
CCR2 promotes monocyte recruitment and intestinal inflammation in mice lacking the interleukin-10 receptor. Sci Rep. 2022 01 10; 12(1):452.
CCR2 promotes monocyte recruitment and intestinal inflammation in mice lacking the interleukin-10 receptor.
Mysore V, Tahir S, Furuhashi K, Arora J, Rosetti F, Cullere X, Yazbeck P, Sekulic M, Lemieux ME, Raychaudhuri S, Horwitz BH, Mayadas TN
Monocytes transition to macrophages within the inflamed vasculature via monocyte CCR2 and endothelial TNFR2. J Exp Med. 2022 05 02; 219(5).
Monocytes transition to macrophages within the inflamed vasculature via monocyte CCR2 and endothelial TNFR2.
Ziegler CGK, Owings AH, Miao VN, Navia AW, Tang Y, Bromley JD, Lotfy P, Sloan M, Laird H, Williams HB, George M, Drake RS, Pride Y, Abraham GE, Senitko M, Robinson TO, Lionakis MS, Shalek AK, Ordovas-Montanes J, Horwitz BH, Glover SC
medRxiv : the preprint server for health sciences
Severe COVID-19 is associated with fungal colonization of the nasopharynx and potent induction of IL-17 responses in the nasal epithelium. medRxiv. 2022 Oct 26.
Severe COVID-19 is associated with fungal colonization of the nasopharynx and potent induction of IL-17 responses in the nasal epithelium.
Patik I, Redhu NS, Eran A, Bao B, Nandy A, Tang Y, El Sayed S, Shen Z, Glickman J, Fox JG, Snapper SB, Horwitz BH
The IL-10 receptor inhibits cell extrinsic signals necessary for STAT1-dependent macrophage accumulation during colitis. Mucosal Immunol. 2023 06; 16(3):233-249.
The IL-10 receptor inhibits cell extrinsic signals necessary for STAT1-dependent macrophage accumulation during colitis.
Nziza N, Deng Y, Wood L, Dhanoa N, Dulit-Greenberg N, Chen T, Kane A, Swank Z, Davis J, Demokritou M, Chitnis AP, Fasano A, Edlow AG, Jain N, Horwitz B, McNamara R, Julg B, Shreffler WG, Alter G, Yonker LM
Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination. Res Sq. 2023 Apr 06.
Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination.
Tomalka JA, Owings A, Galeas-Pena M, Ziegler CGK, Robinson TO, Wichman TG, Laird H, Williams HB, Dhaliwal NS, Everman S, Zafar Y, Shalek AK, Horwitz BH, Ordovas-Montanes J, Glover SC, Gibert Y
Enhanced production of eicosanoids in plasma and activation of DNA damage pathways in PBMCs are correlated with the severity of ancestral COVID-19 infection. medRxiv. 2023 Sep 15.
Enhanced production of eicosanoids in plasma and activation of DNA damage pathways in PBMCs are correlated with the severity of ancestral COVID-19 infection.
Initiation of immune responses to SARS COV2 in the oral cavity and upper airway
Nziza N, Deng Y, Wood L, Dhanoa N, Dulit-Greenberg N, Chen T, Kane AS, Swank Z, Davis JP, Demokritou M, Chitnis AP, Fasano A, Edlow AG, Jain N, Horwitz BH, McNamara RP, Walt DR, Lauffenburger DA, Julg B, Shreffler WG, Alter G, Yonker LM
Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination. Nat Commun. 2024 Jan 30; 15(1):905.
Bao B, Wang Y, Boudreau P, Song X, Wu M, Chen X, Patik I, Tang Y, Ouahed J, Ringel A, Barends J, Wu C, Balskus E, Thiagarajah J, Liu J, Wessels MR, Lencer WI, Kasper DL, An D, Horwitz BH, Snapper SB
Cellular and molecular gastroenterology and hepatology
Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production. Cell Mol Gastroenterol Hepatol. 2024; 18(2):101350.
Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production.
Tang Y, Boribong BP, Swank ZN, Demokritou M, Luban MAF, Fasano A, Du M, Wolf RL, Griffiths J, Shultz J, Borberg E, Chalise S, Gonzalez WI, Walt DR, Yonker LM, Horwitz BH
COVID-19 mRNA vaccines induce robust levels of IgG but limited amounts of IgA within the oronasopharynx of young children. medRxiv. 2024 Apr 16.
COVID-19 mRNA vaccines induce robust levels of IgG but limited amounts of IgA within the oronasopharynx of young children.
Ziegler CGK, Owings AH, Galeas-Pena M, Kazer SW, Miao VN, Navia AW, Tang Y, Bromley JD, Lotfy P, Sloan M, Laird H, Williams HB, George M, Drake RS, Pride Y, Abraham GE, Senitko M, Robinson TO, Diamond G, Lionakis MS, Shalek AK, Ordovas-Montanes J, Horwitz BH, Glover SC
An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection. Microbiol Spectr. 2024 Jun 04; 12(6):e0351623.
An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection.
COVID-19 mRNA Vaccines Induce Robust Levels of IgG but Limited Amounts of IgA Within the Oronasopharynx of Young Children. J Infect Dis. 2024 Dec 16; 230(6):1390-1399.
COVID-19 mRNA Vaccines Induce Robust Levels of IgG but Limited Amounts of IgA Within the Oronasopharynx of Young Children.
Leptak C, Ramon y Cajal S, Kulke R, Horwitz BH, Riese DJ, Dotto GP, DiMaio D
Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16. J Virol. 1991 Dec; 65(12):7078-83.
Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16.
Walsh JML, Miao VN, Owings AH, Tang Y, Bromley JD, Kazer SW, Kimler K, Asare C, Ziegler CGK, Ibrahim S, Jivanjee T, George M, Navia AW, Drake RS, Parker A, Billingsley BC, Dotherow P, Tarugu S, Kota SK, Laird H, Wichman TG, Davis YT, Dhaliwal NS, Pride Y, Guo Y, Senitko M, Harvey J, Bates JT, Diamond G, Garrett MR, Robinson DA, Frame IJ, Lyons JJ, Robinson TO, Shalek AK, Horwitz BH, Glover SC, Ordovas-Montanes J
Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2. Nat Immunol. 2025 Feb; 26(2):294-307.
Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2.
Poutahidis T, Cappelle K, Levkovich T, Lee CW, Doulberis M, Ge Z, Fox JG, Horwitz BH, Erdman SE
Pathogenic intestinal bacteria enhance prostate cancer development via systemic activation of immune cells in mice. PLoS One. 2013; 8(8):e73933.
Pathogenic intestinal bacteria enhance prostate cancer development via systemic activation of immune cells in mice.
Tomalka JA, Owings A, Galeas-Pena M, Ziegler CGK, Robinson TO, Wichman TG, Laird H, Williams HB, Ghaliwal NS, Everman S, Zafar Y, Walsh JML, Shalek AK, Horwitz BH, Ordovas-Montanes J, Glover SC, Gibert Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Enhanced Production of Lipid Mediators in Plasma and Activation of DNA Damage Pathways in PBMCs Are Correlated With the Severity of Ancestral SARS-CoV-2 Infection. FASEB J. 2025 May 15; 39(9):e70600.
Enhanced Production of Lipid Mediators in Plasma and Activation of DNA Damage Pathways in PBMCs Are Correlated With the Severity of Ancestral SARS-CoV-2 Infection.
Shouval DS, Ouahed J, Biswas A, Goettel JA, Horwitz BH, Klein C, Muise AM, Snapper SB
Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans. Adv Immunol. 2014; 122:177-210.
Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans.
Shouval DS, Biswas A, Goettel JA, McCann K, Conaway E, Redhu NS, Mascanfroni ID, Al Adham Z, Lavoie S, Ibourk M, Nguyen DD, Samsom JN, Escher JC, Somech R, Weiss B, Beier R, Conklin LS, Ebens CL, Santos FG, Ferreira AR, Sherlock M, Bhan AK, Müller W, Mora JR, Quintana FJ, Klein C, Muise AM, Horwitz BH, Snapper SB
Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. Immunity. 2014 May 15; 40(5):706-19.
Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.
Transforming activity of a 16-amino-acid segment of the bovine papillomavirus E5 protein linked to random sequences of hydrophobic amino acids. J Virol. 1989 Nov; 63(11):4515-9.
Transforming activity of a 16-amino-acid segment of the bovine papillomavirus E5 protein linked to random sequences of hydrophobic amino acids.
Horvath TL, Diano S, Miyamoto S, Barry S, Gatti S, Alberati D, Livak F, Lombardi A, Moreno M, Goglia F, Mor G, Hamilton J, Kachinskas D, Horwitz B, Warden CH
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice. Int J Obes Relat Metab Disord. 2003 Apr; 27(4):433-42.
Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice.
Kulke R, Horwitz BH, Zibello T, DiMaio D
The central hydrophobic domain of the bovine papillomavirus E5 transforming protein can be functionally replaced by many hydrophobic amino acid sequences containing a glutamine. J Virol. 1992 Jan; 66(1):505-11.
The central hydrophobic domain of the bovine papillomavirus E5 transforming protein can be functionally replaced by many hydrophobic amino acid sequences containing a glutamine.
Horwitz BH, Burkhardt AL, Schlegel R, DiMaio D
44-amino-acid E5 transforming protein of bovine papillomavirus requires a hydrophobic core and specific carboxyl-terminal amino acids. Mol Cell Biol. 1988 Oct; 8(10):4071-8.
44-amino-acid E5 transforming protein of bovine papillomavirus requires a hydrophobic core and specific carboxyl-terminal amino acids.
Goettel JA, Biswas S, Lexmond WS, Yeste A, Passerini L, Patel B, Yang S, Sun J, Ouahed J, Shouval DS, McCann KJ, Horwitz BH, Mathis D, Milford EL, Notarangelo LD, Roncarolo MG, Fiebiger E, Marasco WA, Bacchetta R, Quintana FJ, Pai SY, Klein C, Muise AM, Snapper SB
Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3. Blood. 2015 Jun 18; 125(25):3886-95.
Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.
Redhu N, Shouval D, Bakthavatchalu V, Wang C, Conaway E, Goettel J, Mack M, Bleich A, Bry L, Fox J, Snapper S, Horwitz B
O-005 YI Microbiota Drives Inflammation by Altering Intestinal Lamina Propria Macrophage Phenotype in a Novel IL10R-Deficient Model of Very Early Onset IBD. Inflamm Bowel Dis. 2016 Mar; 22 Suppl 1:S2-3.
O-005 YI Microbiota Drives Inflammation by Altering Intestinal Lamina Propria Macrophage Phenotype in a Novel IL10R-Deficient Model of Very Early Onset IBD.
Inhibition of Microflora-Induced Colitis by NF-kB
Shouval DS, Biswas A, Kang YH, Griffith AE, Konnikova L, Mascanfroni ID, Redhu NS, Frei SM, Field M, Doty AL, Goldsmith JD, Bhan AK, Loizides A, Weiss B, Yerushalmi B, Yanagi T, Lui X, Quintana FJ, Muise AM, Klein C, Horwitz BH, Glover SC, Bousvaros A, Snapper SB
Interleukin 1ß Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency. Gastroenterology. 2016 12; 151(6):1100-1104.
Interleukin 1ß Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency.
Conaway EA, de Oliveira DC, McInnis CM, Snapper SB, Horwitz BH
Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation. J Immunol. 2017 04 01; 198(7):2906-2915.
Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation.
Horwitz BH, Scott ML, Cherry SR, Bronson RT, Baltimore D
Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells. Immunity. 1997 Jun; 6(6):765-72.
Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells.
Alcamo E, Mizgerd JP, Horwitz BH, Bronson R, Beg AA, Scott M, Doerschuk CM, Hynes RO, Baltimore D
Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment. J Immunol. 2001 Aug 01; 167(3):1592-600.
Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment.
Tomczak MF, Erdman SE, Poutahidis T, Rogers AB, Holcombe H, Plank B, Fox JG, Horwitz BH
NF-kappa B is required within the innate immune system to inhibit microflora-induced colitis and expression of IL-12 p40. J Immunol. 2003 Aug 01; 171(3):1484-92.
NF-kappa B is required within the innate immune system to inhibit microflora-induced colitis and expression of IL-12 p40.
Wang C, Gong G, Sheh A, Muthupalani S, Bryant EM, Puglisi DA, Holcombe H, Conaway EA, Parry NAP, Bakthavatchalu V, Short SP, Williams CS, Wogan GN, Tannenbaum SR, Fox JG, Horwitz BH
Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer. Mucosal Immunol. 2017 11; 10(6):1504-1517.
Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer.
Tomczak MF, Erdman SE, Davidson A, Wang YY, Nambiar PR, Rogers AB, Rickman B, Luchetti D, Fox JG, Horwitz BH
Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B. J Immunol. 2006 Nov 15; 177(10):7332-9.
Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B.
Liang SC, Latchman YE, Buhlmann JE, Tomczak MF, Horwitz BH, Freeman GJ, Sharpe AH
Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses. Eur J Immunol. 2003 Oct; 33(10):2706-16.
Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses.
NF-kappaB p50 and p65 subunits control intestinal homeostasis. Eur J Immunol. 2007 Sep; 37(9):2509-17.
NF-kappaB p50 and p65 subunits control intestinal homeostasis.
Cariappa A, Liou HC, Horwitz BH, Pillai S
Nuclear factor kappa B is required for the development of marginal zone B lymphocytes. J Exp Med. 2000 Oct 16; 192(8):1175-82.
Nuclear factor kappa B is required for the development of marginal zone B lymphocytes.
Fox JG, Rogers AB, Whary MT, Ge Z, Taylor NS, Xu S, Horwitz BH, Erdman SE
Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains. Infect Immun. 2004 Feb; 72(2):1116-25.
Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains.
Dedeoglu F, Horwitz B, Chaudhuri J, Alt FW, Geha RS
Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Int Immunol. 2004 Mar; 16(3):395-404.
Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB.
Erdman SE, Poutahidis T, Tomczak M, Rogers AB, Cormier K, Plank B, Horwitz BH, Fox JG
CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice. Am J Pathol. 2003 Feb; 162(2):691-702.
CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice.
Tomczak MF, Gadjeva M, Wang YY, Brown K, Maroulakou I, Tsichlis PN, Erdman SE, Fox JG, Horwitz BH
Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus. J Immunol. 2006 Jan 15; 176(2):1244-51.
Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus.
Murphy CG, Glickman JN, Tomczak K, Wang YY, Beggs AH, Shannon MW, Horwitz BH
Acute appendicitis is characterized by a uniform and highly selective pattern of inflammatory gene expression. Mucosal Immunol. 2008 Jul; 1(4):297-308.
Acute appendicitis is characterized by a uniform and highly selective pattern of inflammatory gene expression.
Kentsis A, Lin YY, Kurek K, Calicchio M, Wang YY, Monigatti F, Campagne F, Lee R, Horwitz B, Steen H, Bachur R
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