Horwitz, Bruce
eCommons Login: BHH1
first name: Bruce
last name: Horwitz
coauthor of: Snapper, Scott
coauthor of: Ziegler, Carly
coauthor of: Ordovas-Montanes, Jose
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full name: Bruce Harold Horwitz, M.D., Ph.D.
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Typhlocolitis in NF-kappa B-deficient mice.
PubMed Identifier: 11160181
author list: Erdman S, Fox JG, Dangler CA, Feldman D, Horwitz BH
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Typhlocolitis in NF-kappa B-deficient mice. J Immunol. 2001 Feb 01; 166(3):1443-7.
journal title abbreviation: J Immunol
publication date: 2001-02-01T00:00:00
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type: Academic Article
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Proinflammatory CD4+ CD45RB(hi) lymphocytes promote mammary and intestinal carcinogenesis in Apc(Min/+) mice.
PubMed Identifier: 16397216
author list: Rao VP, Poutahidis T, Ge Z, Nambiar PR, Horwitz BH, Fox JG, Erdman SE
published in: Cancer research
information resource reference: Proinflammatory CD4+ CD45RB(hi) lymphocytes promote mammary and intestinal carcinogenesis in Apc(Min/+) mice. Cancer Res. 2006 Jan 01; 66(1):57-61.
journal title abbreviation: Cancer Res
publication date: 2006-01-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
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Authorship 111054
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author rank in publication: 8
linked author: Horwitz, Bruce
linked information resource: c-Rel is essential for the development of innate and T cell-induced colitis.

Authorship 1062328
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author rank in publication: 16
linked author: Horwitz, Bruce
linked information resource: WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis.

WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis.
PubMed Identifier: 29725003
author list: Biswas A, Shouval DS, Griffith A, Goettel JA, Field M, Kang YH, Konnikova L, Janssen E, Redhu NS, Thrasher AJ, Chatila T, Kuchroo VK, Geha RS, Notarangelo LD, Pai SY, Horwitz BH, Snapper SB
published in: Nature communications
information resource reference: WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. Nat Commun. 2018 05 03; 9(1):1779.
journal title abbreviation: Nat Commun
publication date: 2018-05-03T00:00:00
year: 2018
type: Academic Article
type: Article
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Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma.
PubMed Identifier: 17724375
author list: Poutahidis T, Haigis KM, Rao VP, Nambiar PR, Taylor CL, Ge Z, Watanabe K, Davidson A, Horwitz BH, Fox JG, Erdman SE
published in: Carcinogenesis
information resource reference: Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. Carcinogenesis. 2007 Dec; 28(12):2614-23.
journal title abbreviation: Carcinogenesis
publication date: 2007-08-27T00:00:00
year: 2007
type: Academic Article
type: Article
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Bovine papillomavirus E2 gene regulates expression of the viral E5 transforming gene.
PubMed Identifier: 2843663
author list: Prakash SS, Horwitz BH, Zibello T, Settleman J, DiMaio D
published in: Journal of virology
information resource reference: Bovine papillomavirus E2 gene regulates expression of the viral E5 transforming gene. J Virol. 1988 Oct; 62(10):3608-13.
journal title abbreviation: J Virol
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Mechanisms of granulocytosis in the absence of CD18.
PubMed Identifier: 11238094
author list: Horwitz BH, Mizgerd JP, Scott ML, Doerschuk CM
published in: Blood
information resource reference: Mechanisms of granulocytosis in the absence of CD18. Blood. 2001 Mar 15; 97(6):1578-83.
journal title abbreviation: Blood
publication date: 2001-03-15T00:00:00
year: 2001
type: Academic Article
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Genetic evidence that acute morphologic transformation, induction of cellular DNA synthesis, and focus formation are mediated by a single activity of the bovine papillomavirus E5 protein.
PubMed Identifier: 2555701
author list: Settleman J, Fazeli A, Malicki J, Horwitz BH, DiMaio D
published in: Molecular and cellular biology
information resource reference: Genetic evidence that acute morphologic transformation, induction of cellular DNA synthesis, and focus formation are mediated by a single activity of the bovine papillomavirus E5 protein. Mol Cell Biol. 1989 Dec; 9(12):5563-72.
journal title abbreviation: Mol Cell Biol
publication date: 1989-12-01T00:00:00
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type: Academic Article
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type: Information Resource

Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice.
PubMed Identifier: 16885333
author list: Rao VP, Poutahidis T, Ge Z, Nambiar PR, Boussahmain C, Wang YY, Horwitz BH, Fox JG, Erdman SE
published in: Cancer research
information resource reference: Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice. Cancer Res. 2006 Aug 01; 66(15):7395-400.
journal title abbreviation: Cancer Res
publication date: 2006-08-01T00:00:00
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The straw that stirs the drink: insight into the pathogenesis of inflammatory bowel disease revealed through the study of microflora-induced inflammation in genetically modified mice.
PubMed Identifier: 17243141
author list: Horwitz BH
published in: Inflammatory bowel diseases
information resource reference: The straw that stirs the drink: insight into the pathogenesis of inflammatory bowel disease revealed through the study of microflora-induced inflammation in genetically modified mice. Inflamm Bowel Dis. 2007 Apr; 13(4):490-500.
journal title abbreviation: Inflamm Bowel Dis
publication date: 2007-04-01T00:00:00
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Cytotoxic-T-lymphocyte-associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis.
PubMed Identifier: 18824539
author list: Watanabe K, Rao VP, Poutahidis T, Rickman BH, Ohtani M, Xu S, Rogers AB, Ge Z, Horwitz BH, Fujioka T, Erdman SE, Fox JG
published in: Infection and immunity
information resource reference: Cytotoxic-T-lymphocyte-associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis. Infect Immun. 2008 Dec; 76(12):5834-42.
journal title abbreviation: Infect Immun
publication date: 2008-09-29T00:00:00
year: 2008
type: Academic Article
type: Article
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type: Information Resource

NF-?B1 inhibits TLR-induced IFN-ß production in macrophages through TPL-2-dependent ERK activation.
PubMed Identifier: 21217011
author list: Yang HT, Wang Y, Zhao X, Demissie E, Papoutsopoulou S, Mambole A, O'Garra A, Tomczak MF, Erdman SE, Fox JG, Ley SC, Horwitz BH
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: NF-?B1 inhibits TLR-induced IFN-ß production in macrophages through TPL-2-dependent ERK activation. J Immunol. 2011 Feb 15; 186(4):1989-96.
journal title abbreviation: J Immunol
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Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice.
PubMed Identifier: 22710191
author list: Nguyen DD, Wurbel MA, Goettel JA, Eston MA, Ahmed OS, Marin R, Boden EK, Villablanca EJ, Paidassi H, Ahuja V, Reinecker HC, Fiebiger E, Lacy-Hulbert A, Horwitz BH, Mora JR, Snapper SB
published in: Gastroenterology
information resource reference: Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice. Gastroenterology. 2012 Sep; 143(3):719-729.e2.
journal title abbreviation: Gastroenterology
publication date: 2012-06-15T00:00:00
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Authorship 104394
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author rank in publication: 5
linked author: Horwitz, Bruce
linked information resource: Proinflammatory CD4+ CD45RB(hi) lymphocytes promote mammary and intestinal carcinogenesis in Apc(Min/+) mice.

Authorship 1092970
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linked author: Horwitz, Bruce
linked information resource: Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis.

Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis.
PubMed Identifier: 30228258
author list: Ryzhakov G, West NR, Franchini F, Clare S, Ilott NE, Sansom SN, Bullers SJ, Pearson C, Costain A, Vaughan-Jackson A, Goettel JA, Ermann J, Horwitz BH, Buti L, Lu X, Mukhopadhyay S, Snapper SB, Powrie F
published in: Nature communications
information resource reference: Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis. Nat Commun. 2018 09 18; 9(1):3797.
journal title abbreviation: Nat Commun
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type: Article
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type: Information Resource

Authorship 14271
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author rank in publication: 1
linked author: Horwitz, Bruce
linked information resource: The straw that stirs the drink: insight into the pathogenesis of inflammatory bowel disease revealed through the study of microflora-induced inflammation in genetically modified mice.

Effects of CD18 deficiency on the emigration of murine neutrophils during pneumonia.
PubMed Identifier: 10395697
author list: Mizgerd JP, Horwitz BH, Quillen HC, Scott ML, Doerschuk CM
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Effects of CD18 deficiency on the emigration of murine neutrophils during pneumonia. J Immunol. 1999 Jul 15; 163(2):995-9.
journal title abbreviation: J Immunol
publication date: 1999-07-15T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 111509
type: Authorship
author rank in publication: 7
linked author: Horwitz, Bruce
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/788383

Helicobacter hepaticus
MeSH DescriptorUI: D044923
MeSH semantic group name: Living Beings
number of authors: 13
number of publications: 28
uniqueness weight: 0.985851
type: Concept

Helicobacter Infections
MeSH DescriptorUI: D016481
MeSH semantic group name: Disorders
number of authors: 218
number of publications: 453
uniqueness weight: 0.730459
type: Concept

NF-kappa B p50 Subunit
MeSH DescriptorUI: D052002
MeSH semantic group name: Chemicals & Drugs
number of authors: 82
number of publications: 104
uniqueness weight: 0.943205
type: Concept

Experimental Medicine Unit - CCIB
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Residents
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Interleukin-10
MeSH DescriptorUI: D016753
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number of authors: 652
number of publications: 1253
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Colitis
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number of publications: 1307
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Medicine
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Neurology
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Pathology
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Pediatrics
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Cardiology
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Genetics
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Emergency Medicine
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Immunology
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Vaccine Research
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Beth Israel Deaconess Medical Center
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Brigham and Women's Hospital
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Boston Children's Hospital
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Massachusetts General Hospital
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Xavier, Ramnik
eCommons Login: RX1
first name: Ramnik
last name: Xavier
full name: Ramnik Xavier, M.B.,B.Ch.
has faculty rank: Full Professor
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person in primary position: Kurt J. Isselbacher Professor of Medicine in the Field of Gastroenterology
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Fasano, Alessio
eCommons Login: AF136
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person in primary position: Professor of Pediatrics
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Ordovas-Montanes, Jose
eCommons Login: JMO16
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Barouch, Dan
eCommons Login: DHB3
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Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-ß autocrine signaling to promote monocyte recruitment.
PubMed Identifier: 23623383
author list: Venkatesh D, Ernandez T, Rosetti F, Batal I, Cullere X, Luscinskas FW, Zhang Y, Stavrakis G, García-Cardeña G, Horwitz BH, Mayadas TN
published in: Immunity
information resource reference: Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-ß autocrine signaling to promote monocyte recruitment. Immunity. 2013 May 23; 38(5):1025-37.
journal title abbreviation: Immunity
publication date: 2013-04-25T00:00:00
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type: Academic Article
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selected publications
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Snapper, Scott
eCommons Login: SBS4
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person in primary position: Egan Family Foundation Professor of Pediatrics in the Field of Transitional Medicine
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Katz, Tamar
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Alkuraya, Fowzan
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person in primary position: Instructor in Pediatrics
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Roberts, Amy
eCommons Login: AER8
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person in primary position: Associate Professor of Pediatrics
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Mochida, Ganeshwaran
eCommons Login: GHM1
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person in primary position: Assistant Professor of Pediatrics
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Kuchroo, Vijay
eCommons Login: VKK1
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last name: Kuchroo
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latitude: 42.33837200000000
longitude: -71.10326900000000
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person in primary position: Samuel L. Wasserstrom Professor of Neurology
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Glickman, Jonathan
eCommons Login: JNG1
first name: Jonathan
last name: Glickman
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has faculty rank: Associate Professor
latitude: 42.30734190000000
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person in primary position: Associate Professor of Pathology
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Hill, Robert
eCommons Login: RSH11
first name: Robert
last name: Hill
full name: Robert Sean Hill, Ph.D.
has faculty rank: Instructor
latitude: 42.33837200000000
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person in primary position: Instructor in Pediatrics
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Authorship 1200500
type: Authorship
author rank in publication: 14
linked author: Horwitz, Bruce
linked information resource: Generation of protective pneumococcal-specific nasal resident memory CD4+ T cells via parenteral immunization.

Generation of protective pneumococcal-specific nasal resident memory CD4+ T cells via parenteral immunization.
PubMed Identifier: 31659300
author list: O'Hara JM, Redhu NS, Cheung E, Robertson NG, Patik I, Sayed SE, Thompson CM, Herd M, Lucas KB, Conaway E, Morton CC, Farber DL, Malley R, Horwitz BH
published in: Mucosal immunology
information resource reference: Generation of protective pneumococcal-specific nasal resident memory CD4+ T cells via parenteral immunization. Mucosal Immunol. 2020 01; 13(1):172-182.
journal title abbreviation: Mucosal Immunol
publication date: 2019-10-28T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 134609
type: Authorship
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linked author: Horwitz, Bruce
linked information resource: The p65 subunit of NF-kappa B is redundant with p50 during B cell proliferative responses, and is required for germline CH transcription and class switching to IgG3.

Authorship 157437
type: Authorship
author rank in publication: 4
linked author: Horwitz, Bruce
linked information resource: Serum markers in acute appendicitis.

Authorship 1243494
type: Authorship
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linked author: Horwitz, Bruce
linked information resource: Effects of Colonization of Gnotobiotic Swiss Webster Mice with Helicobacter bilis.

Effects of Colonization of Gnotobiotic Swiss Webster Mice with Helicobacter bilis.
PubMed Identifier: 32349859
author list: Whary MT, Wang C, Ruff CF, DiVincenzo MJ, Labriola C, Ge L, Feng Y, Ge Z, Bakthavatchalu V, Muthupalani S, Horwitz BH, Fox JG
published in: Comparative medicine
information resource reference: Effects of Colonization of Gnotobiotic Swiss Webster Mice with Helicobacter bilis. Comp Med. 2020 06 01; 70(3):216-232.
journal title abbreviation: Comp Med
publication date: 2020-04-29T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1246906
type: Authorship
author rank in publication: 16
linked author: Horwitz, Bruce
linked information resource: Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn's Disease.

Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn's Disease.
PubMed Identifier: 32428507
author list: Mitsialis V, Wall S, Liu P, Ordovas-Montanes J, Parmet T, Vukovic M, Spencer D, Field M, McCourt C, Toothaker J, Bousvaros A, Shalek AK, Kean L, Horwitz B, Goldsmith J, Tseng G, Snapper SB, Konnikova L
published in: Gastroenterology
information resource reference: Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn's Disease. Gastroenterology. 2020 08; 159(2):591-608.e10.
journal title abbreviation: Gastroenterology
publication date: 2020-05-16T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 195982
type: Authorship
author rank in publication: 10
linked author: Horwitz, Bruce
linked information resource: A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock.

Authorship 141481
type: Authorship
author rank in publication: 3
linked author: Horwitz, Bruce
linked information resource: Nuclear factor kappa B is required for the development of marginal zone B lymphocytes.

Authorship 137678
type: Authorship
author rank in publication: 2
linked author: Horwitz, Bruce
linked information resource: Effects of CD18 deficiency on the emigration of murine neutrophils during pneumonia.

Authorship 1323592
type: Authorship
author rank in publication: 5
linked author: Horwitz, Bruce
linked information resource: Characterizing T cell subsets in the nasal mucosa of children with acute respiratory symptoms.

Characterizing T cell subsets in the nasal mucosa of children with acute respiratory symptoms.
PubMed Identifier: 33504970
author list: Cosgrove PR, Redhu NS, Tang Y, Monuteaux MC, Horwitz BH
published in: Pediatric research
information resource reference: Characterizing T cell subsets in the nasal mucosa of children with acute respiratory symptoms. Pediatr Res. 2021 11; 90(5):1023-1030.
journal title abbreviation: Pediatr Res
publication date: 2021-01-27T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1332936
type: Authorship
author rank in publication: 24
linked author: Horwitz, Bruce
linked information resource: Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19.

Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19.
PubMed Identifier: 33619488
author list: Ziegler CGK, Miao VN, Owings AH, Navia AW, Tang Y, Bromley JD, Lotfy P, Sloan M, Laird H, Williams HB, George M, Drake RS, Christian T, Parker A, Sindel CB, Burger MW, Pride Y, Hasan M, Abraham GE, Senitko M, Robinson TO, Shalek AK, Glover SC, Horwitz BH, Ordovas-Montanes J
published in: bioRxiv : the preprint server for biology
information resource reference: Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19. bioRxiv. 2021 Feb 20.
journal title abbreviation: bioRxiv
publication date: 2021-02-20T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1336611
type: Authorship
author rank in publication: 4
linked author: Horwitz, Bruce
linked information resource: Brain activity during transient sadness and happiness in healthy women.

Authorship 1335743
type: Authorship
author rank in publication: 8
linked author: Horwitz, Bruce
linked information resource: Regional brain activity when selecting a response despite interference: An H2 (15) O PET study of the stroop and an emotional stroop.

Authorship 1336784
type: Authorship
author rank in publication: 8
linked author: Horwitz, Bruce
linked information resource: Inverse relationship of peripheral thyrotropin-stimulating hormone levels to brain activity in mood disorders.

Inverse relationship of peripheral thyrotropin-stimulating hormone levels to brain activity in mood disorders.
PubMed Identifier: 9016272
author list: Marangell LB, Ketter TA, George MS, Pazzaglia PJ, Callahan AM, Parekh P, Andreason PJ, Horwitz B, Herscovitch P, Post RM
published in: The American journal of psychiatry
information resource reference: Inverse relationship of peripheral thyrotropin-stimulating hormone levels to brain activity in mood disorders. Am J Psychiatry. 1997 Feb; 154(2):224-30.
journal title abbreviation: Am J Psychiatry
publication date: 1997-02-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Regional brain activity when selecting a response despite interference: An H2 (15) O PET study of the stroop and an emotional stroop.
PubMed Identifier: 24578040
author list: George MS, Ketter TA, Parekh PI, Rosinsky N, Ring H, Casey BJ, Trimble MR, Horwitz B, Herscovitch P, Post RM
published in: Human brain mapping
information resource reference: Regional brain activity when selecting a response despite interference: An H2 (15) O PET study of the stroop and an emotional stroop. Hum Brain Mapp. 1994; 1(3):194-209.
journal title abbreviation: Hum Brain Mapp
publication date: 1994-01-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Brain activity during transient sadness and happiness in healthy women.
PubMed Identifier: 7864258
author list: George MS, Ketter TA, Parekh PI, Horwitz B, Herscovitch P, Post RM
published in: The American journal of psychiatry
information resource reference: Brain activity during transient sadness and happiness in healthy women. Am J Psychiatry. 1995 Mar; 152(3):341-51.
journal title abbreviation: Am J Psychiatry
publication date: 1995-03-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1348914
type: Authorship
author rank in publication: 27
linked author: Horwitz, Bruce
linked information resource: Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation.

Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation.
PubMed Identifier: 33891011
author list: Ouahed J, Kelsen JR, Spessott WA, Kooshesh K, Sanmillan ML, Dawany N, Sullivan KE, Hamilton KE, Slowik V, Nejentsev S, Neves JF, Flores H, Chung WK, Wilson A, Anyane-Yeboa K, Wou K, Jain P, Field M, Tollefson S, Dent MH, Li D, Naito T, McGovern DPB, Kwong AC, Taliaferro F, Ordovas-Montanes J, Horwitz BH, Kotlarz D, Klein C, Evans J, Dorsey J, Warner N, Elkadri A, Muise AM, Goldsmith J, Thompson B, Engelhardt KR, Cant AJ, Hambleton S, Barclay A, Toth-Petroczy A, Vuzman D, Carmichael N, Bodea C, Cassa CA, Devoto M, Maas RL, Behrens EM, Giraudo CG, Snapper SB
published in: Journal of Crohn's & colitis
information resource reference: Variants in STXBP3 are Associated with Very Early Onset Inflammatory Bowel Disease, Bilateral Sensorineural Hearing Loss and Immune Dysregulation. J Crohns Colitis. 2021 Nov 08; 15(11):1908-1919.
journal title abbreviation: J Crohns Colitis
publication date: 2021-11-08T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1358792
type: Authorship
author rank in publication: 16
linked author: Horwitz, Bruce
linked information resource: Increased ACE2 Levels and Mortality Risk of Patients With COVID-19 on Proton Pump Inhibitor Therapy.

Increased ACE2 Levels and Mortality Risk of Patients With COVID-19 on Proton Pump Inhibitor Therapy.
PubMed Identifier: 34047305
author list: Liu JJ, Sloan ME, Owings AH, Figgins E, Gauthier J, Gharaibeh R, Robinson T, Williams H, Sindel CB, Backus F, Ayyalasomayajula K, Parker A, Senitko M, Abraham GE, Claggett B, Horwitz BH, Jobin C, Adelman RM, Diamond G, Glover SC
published in: The American journal of gastroenterology
information resource reference: Increased ACE2 Levels and Mortality Risk of Patients With COVID-19 on Proton Pump Inhibitor Therapy. Am J Gastroenterol. 2021 08 01; 116(8):1638-1645.
journal title abbreviation: Am J Gastroenterol
publication date: 2021-08-01T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1382946
type: Authorship
author rank in publication: 24
linked author: Horwitz, Bruce
linked information resource: Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19.

Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19.
PubMed Identifier: 34352228
author list: Ziegler CGK, Miao VN, Owings AH, Navia AW, Tang Y, Bromley JD, Lotfy P, Sloan M, Laird H, Williams HB, George M, Drake RS, Christian T, Parker A, Sindel CB, Burger MW, Pride Y, Hasan M, Abraham GE, Senitko M, Robinson TO, Shalek AK, Glover SC, Horwitz BH, Ordovas-Montanes J
published in: Cell
information resource reference: Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19. Cell. 2021 09 02; 184(18):4713-4733.e22.
journal title abbreviation: Cell
publication date: 2021-07-23T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1383601
type: Authorship
author rank in publication: 2
linked author: Horwitz, Bruce
linked information resource: Bovine papillomavirus E2 gene regulates expression of the viral E5 transforming gene.

Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation.
PubMed Identifier: 34732258
author list: Tsou AM, Goettel JA, Bao B, Biswas A, Kang YH, Redhu NS, Peng K, Putzel GG, Saltzman J, Kelly R, Gringauz J, Barends J, Hatazaki M, Frei SM, Emani R, Huang Y, Shen Z, Fox JG, Glickman JN, Horwitz BH, Snapper SB
published in: Microbiome
information resource reference: Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation. Microbiome. 2021 11 03; 9(1):215.
journal title abbreviation: Microbiome
publication date: 2021-11-03T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1413293
type: Authorship
author rank in publication: 20
linked author: Horwitz, Bruce
linked information resource: Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation.

CCR2 promotes monocyte recruitment and intestinal inflammation in mice lacking the interleukin-10 receptor.
PubMed Identifier: 35013585
author list: El Sayed S, Patik I, Redhu NS, Glickman JN, Karagiannis K, El Naenaeey ESY, Elmowalid GA, Abd El Wahab AM, Snapper SB, Horwitz BH
published in: Scientific reports
information resource reference: CCR2 promotes monocyte recruitment and intestinal inflammation in mice lacking the interleukin-10 receptor. Sci Rep. 2022 01 10; 12(1):452.
journal title abbreviation: Sci Rep
publication date: 2022-01-10T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1425551
type: Authorship
author rank in publication: 10
linked author: Horwitz, Bruce
linked information resource: CCR2 promotes monocyte recruitment and intestinal inflammation in mice lacking the interleukin-10 receptor.

Authorship 1448295
type: Authorship
author rank in publication: 11
linked author: Horwitz, Bruce
linked information resource: Monocytes transition to macrophages within the inflamed vasculature via monocyte CCR2 and endothelial TNFR2.

Monocytes transition to macrophages within the inflamed vasculature via monocyte CCR2 and endothelial TNFR2.
PubMed Identifier: 35404389
author list: Mysore V, Tahir S, Furuhashi K, Arora J, Rosetti F, Cullere X, Yazbeck P, Sekulic M, Lemieux ME, Raychaudhuri S, Horwitz BH, Mayadas TN
published in: The Journal of experimental medicine
information resource reference: Monocytes transition to macrophages within the inflamed vasculature via monocyte CCR2 and endothelial TNFR2. J Exp Med. 2022 05 02; 219(5).
journal title abbreviation: J Exp Med
publication date: 2022-04-11T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1502689
type: Authorship
author rank in publication: 20
linked author: Horwitz, Bruce
linked information resource: Severe COVID-19 is associated with fungal colonization of the nasopharynx and potent induction of IL-17 responses in the nasal epithelium.

Severe COVID-19 is associated with fungal colonization of the nasopharynx and potent induction of IL-17 responses in the nasal epithelium.
PubMed Identifier: 36324802
author list: Ziegler CGK, Owings AH, Miao VN, Navia AW, Tang Y, Bromley JD, Lotfy P, Sloan M, Laird H, Williams HB, George M, Drake RS, Pride Y, Abraham GE, Senitko M, Robinson TO, Lionakis MS, Shalek AK, Ordovas-Montanes J, Horwitz BH, Glover SC
published in: medRxiv : the preprint server for health sciences
information resource reference: Severe COVID-19 is associated with fungal colonization of the nasopharynx and potent induction of IL-17 responses in the nasal epithelium. medRxiv. 2022 Oct 26.
journal title abbreviation: medRxiv
publication date: 2022-10-26T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

The IL-10 receptor inhibits cell extrinsic signals necessary for STAT1-dependent macrophage accumulation during colitis.
PubMed Identifier: 36868479
author list: Patik I, Redhu NS, Eran A, Bao B, Nandy A, Tang Y, El Sayed S, Shen Z, Glickman J, Fox JG, Snapper SB, Horwitz BH
published in: Mucosal immunology
information resource reference: The IL-10 receptor inhibits cell extrinsic signals necessary for STAT1-dependent macrophage accumulation during colitis. Mucosal Immunol. 2023 06; 16(3):233-249.
journal title abbreviation: Mucosal Immunol
publication date: 2023-03-02T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1528527
type: Authorship
author rank in publication: 12
linked author: Horwitz, Bruce
linked information resource: The IL-10 receptor inhibits cell extrinsic signals necessary for STAT1-dependent macrophage accumulation during colitis.

Associate Professor of Pathology
is primary position: true
position in department: Pathology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Associate Professor of Pathology
position in organization: Massachusetts General Hospital

Ziegler, Carly
eCommons Login: CGZ1
first name: Carly
last name: Ziegler
full name: Carly Gail Kean Ziegler, M.D., Ph.D.
has faculty rank: Fellow or Post Doc
Person ID: 127269
person in primary position: Clinical Fellow in Pediatrics
type: Agent
type: Person
preferred title: Clinical Fellow in Pediatrics

Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination.
PubMed Identifier: 37066325
author list: Nziza N, Deng Y, Wood L, Dhanoa N, Dulit-Greenberg N, Chen T, Kane A, Swank Z, Davis J, Demokritou M, Chitnis AP, Fasano A, Edlow AG, Jain N, Horwitz B, McNamara R, Julg B, Shreffler WG, Alter G, Yonker LM
published in: Research square
information resource reference: Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination. Res Sq. 2023 Apr 06.
journal title abbreviation: Res Sq
publication date: 2023-04-06T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 353219
type: Authorship
author rank in publication: 7
linked author: Horwitz, Bruce
linked information resource: Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice.

Authorship 1582734
type: Authorship
author rank in publication: 13
linked author: Horwitz, Bruce
linked information resource: Enhanced production of eicosanoids in plasma and activation of DNA damage pathways in PBMCs are correlated with the severity of ancestral COVID-19 infection.

Enhanced production of eicosanoids in plasma and activation of DNA damage pathways in PBMCs are correlated with the severity of ancestral COVID-19 infection.
PubMed Identifier: 37745424
author list: Tomalka JA, Owings A, Galeas-Pena M, Ziegler CGK, Robinson TO, Wichman TG, Laird H, Williams HB, Dhaliwal NS, Everman S, Zafar Y, Shalek AK, Horwitz BH, Ordovas-Montanes J, Glover SC, Gibert Y
published in: medRxiv : the preprint server for health sciences
information resource reference: Enhanced production of eicosanoids in plasma and activation of DNA damage pathways in PBMCs are correlated with the severity of ancestral COVID-19 infection. medRxiv. 2023 Sep 15.
journal title abbreviation: medRxiv
publication date: 2023-09-15T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1603362
type: Authorship
author rank in publication: 15
linked author: Horwitz, Bruce
linked information resource: Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination.

Initiation of immune responses to SARS COV2 in the oral cavity and upper airway
end date: 2027-03-31
principal investigator name: GLOVER, SARAH C
start date: 2022-04-01
type: Grant
sponsor award id: R01DE031928

Co-Principal Investigator
type: Researcher Role
researcher role of: Horwitz, Bruce
contributes to: Initiation of immune responses to SARS COV2 in the oral cavity and upper airway

Authorship 1626125
type: Authorship
author rank in publication: 15
linked author: Horwitz, Bruce
linked information resource: Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination.

Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination.
PubMed Identifier: 38291080
author list: Nziza N, Deng Y, Wood L, Dhanoa N, Dulit-Greenberg N, Chen T, Kane AS, Swank Z, Davis JP, Demokritou M, Chitnis AP, Fasano A, Edlow AG, Jain N, Horwitz BH, McNamara RP, Walt DR, Lauffenburger DA, Julg B, Shreffler WG, Alter G, Yonker LM
published in: Nature communications
information resource reference: Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination. Nat Commun. 2024 Jan 30; 15(1):905.
journal title abbreviation: Nat Commun
publication date: 2024-01-30T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production.
PubMed Identifier: 38704148
author list: Bao B, Wang Y, Boudreau P, Song X, Wu M, Chen X, Patik I, Tang Y, Ouahed J, Ringel A, Barends J, Wu C, Balskus E, Thiagarajah J, Liu J, Wessels MR, Lencer WI, Kasper DL, An D, Horwitz BH, Snapper SB
published in: Cellular and molecular gastroenterology and hepatology
information resource reference: Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production. Cell Mol Gastroenterol Hepatol. 2024; 18(2):101350.
journal title abbreviation: Cell Mol Gastroenterol Hepatol
publication date: 2024-05-03T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1649186
type: Authorship
author rank in publication: 20
linked author: Horwitz, Bruce
linked information resource: Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production.

Authorship 1652611
type: Authorship
author rank in publication: 16
linked author: Horwitz, Bruce
linked information resource: COVID-19 mRNA vaccines induce robust levels of IgG but limited amounts of IgA within the oronasopharynx of young children.

Authorship 1648725
type: Authorship
author rank in publication: 23
linked author: Horwitz, Bruce
linked information resource: An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection.

COVID-19 mRNA vaccines induce robust levels of IgG but limited amounts of IgA within the oronasopharynx of young children.
PubMed Identifier: 38699375
author list: Tang Y, Boribong BP, Swank ZN, Demokritou M, Luban MAF, Fasano A, Du M, Wolf RL, Griffiths J, Shultz J, Borberg E, Chalise S, Gonzalez WI, Walt DR, Yonker LM, Horwitz BH
published in: medRxiv : the preprint server for health sciences
information resource reference: COVID-19 mRNA vaccines induce robust levels of IgG but limited amounts of IgA within the oronasopharynx of young children. medRxiv. 2024 Apr 16.
journal title abbreviation: medRxiv
publication date: 2024-04-16T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection.
PubMed Identifier: 38687064
author list: Ziegler CGK, Owings AH, Galeas-Pena M, Kazer SW, Miao VN, Navia AW, Tang Y, Bromley JD, Lotfy P, Sloan M, Laird H, Williams HB, George M, Drake RS, Pride Y, Abraham GE, Senitko M, Robinson TO, Diamond G, Lionakis MS, Shalek AK, Ordovas-Montanes J, Horwitz BH, Glover SC
published in: Microbiology spectrum
information resource reference: An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection. Microbiol Spectr. 2024 Jun 04; 12(6):e0351623.
journal title abbreviation: Microbiol Spectr
publication date: 2024-04-30T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

William Bosworth Castle Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Vaccine Research
sort order: 1
type: Position
HR job title: William Bosworth Castle Professor of Medicine
position in organization: Beth Israel Deaconess Medical Center

Kurt J. Isselbacher Professor of Medicine in the Field of Gastroenterology
is primary position: true
position in department: Medicine
position in division: Gastroenterology
sort order: 1
type: Position
HR job title: Kurt J. Isselbacher Professor of Medicine in the Field of Gastroenterology
position in organization: Massachusetts General Hospital

Authorship 644520
type: Authorship
author rank in publication: 10
linked author: Horwitz, Bruce
linked information resource: Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-ß autocrine signaling to promote monocyte recruitment.

Authorship 1694908
type: Authorship
author rank in publication: 16
linked author: Horwitz, Bruce
linked information resource: COVID-19 mRNA Vaccines Induce Robust Levels of IgG but Limited Amounts of IgA Within the Oronasopharynx of Young Children.

COVID-19 mRNA Vaccines Induce Robust Levels of IgG but Limited Amounts of IgA Within the Oronasopharynx of Young Children.
PubMed Identifier: 39253950
author list: Tang Y, Boribong BP, Swank ZN, Demokritou M, Luban MAF, Fasano A, Du M, Wolf RL, Griffiths J, Shultz J, Borberg E, Chalise S, Gonzalez WI, Walt DR, Yonker LM, Horwitz BH
published in: The Journal of infectious diseases
information resource reference: COVID-19 mRNA Vaccines Induce Robust Levels of IgG but Limited Amounts of IgA Within the Oronasopharynx of Young Children. J Infect Dis. 2024 Dec 16; 230(6):1390-1399.
journal title abbreviation: J Infect Dis
publication date: 2024-12-16T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16.
PubMed Identifier: 1658398
author list: Leptak C, Ramon y Cajal S, Kulke R, Horwitz BH, Riese DJ, Dotto GP, DiMaio D
published in: Journal of virology
information resource reference: Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16. J Virol. 1991 Dec; 65(12):7078-83.
journal title abbreviation: J Virol
publication date: 1991-12-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1723965
type: Authorship
author rank in publication: 36
linked author: Horwitz, Bruce
linked information resource: Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2.

Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2.
PubMed Identifier: 39833605
author list: Walsh JML, Miao VN, Owings AH, Tang Y, Bromley JD, Kazer SW, Kimler K, Asare C, Ziegler CGK, Ibrahim S, Jivanjee T, George M, Navia AW, Drake RS, Parker A, Billingsley BC, Dotherow P, Tarugu S, Kota SK, Laird H, Wichman TG, Davis YT, Dhaliwal NS, Pride Y, Guo Y, Senitko M, Harvey J, Bates JT, Diamond G, Garrett MR, Robinson DA, Frame IJ, Lyons JJ, Robinson TO, Shalek AK, Horwitz BH, Glover SC, Ordovas-Montanes J
published in: Nature immunology
information resource reference: Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2. Nat Immunol. 2025 Feb; 26(2):294-307.
journal title abbreviation: Nat Immunol
publication date: 2025-01-20T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 677970
type: Authorship
author rank in publication: 8
linked author: Horwitz, Bruce
linked information resource: Pathogenic intestinal bacteria enhance prostate cancer development via systemic activation of immune cells in mice.

Pathogenic intestinal bacteria enhance prostate cancer development via systemic activation of immune cells in mice.
PubMed Identifier: 23991210
author list: Poutahidis T, Cappelle K, Levkovich T, Lee CW, Doulberis M, Ge Z, Fox JG, Horwitz BH, Erdman SE
published in: PloS one
information resource reference: Pathogenic intestinal bacteria enhance prostate cancer development via systemic activation of immune cells in mice. PLoS One. 2013; 8(8):e73933.
journal title abbreviation: PLoS One
publication date: 2013-08-26T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1744469
type: Authorship
author rank in publication: 14
linked author: Horwitz, Bruce
linked information resource: Enhanced Production of Lipid Mediators in Plasma and Activation of DNA Damage Pathways in PBMCs Are Correlated With the Severity of Ancestral SARS-CoV-2 Infection.

Enhanced Production of Lipid Mediators in Plasma and Activation of DNA Damage Pathways in PBMCs Are Correlated With the Severity of Ancestral SARS-CoV-2 Infection.
PubMed Identifier: 40322970
author list: Tomalka JA, Owings A, Galeas-Pena M, Ziegler CGK, Robinson TO, Wichman TG, Laird H, Williams HB, Ghaliwal NS, Everman S, Zafar Y, Walsh JML, Shalek AK, Horwitz BH, Ordovas-Montanes J, Glover SC, Gibert Y
published in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
information resource reference: Enhanced Production of Lipid Mediators in Plasma and Activation of DNA Damage Pathways in PBMCs Are Correlated With the Severity of Ancestral SARS-CoV-2 Infection. FASEB J. 2025 May 15; 39(9):e70600.
journal title abbreviation: FASEB J
publication date: 2025-05-15T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 373686
type: Authorship
author rank in publication: 9
linked author: Horwitz, Bruce
linked information resource: Cytotoxic-T-lymphocyte-associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis.

Authorship 6588
type: Authorship
author rank in publication: 5
linked author: Horwitz, Bruce
linked information resource: Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer.

Authorship 724807
type: Authorship
author rank in publication: 5
linked author: Horwitz, Bruce
linked information resource: Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans.

Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans.
PubMed Identifier: 24507158
author list: Shouval DS, Ouahed J, Biswas A, Goettel JA, Horwitz BH, Klein C, Muise AM, Snapper SB
published in: Advances in immunology
information resource reference: Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans. Adv Immunol. 2014; 122:177-210.
journal title abbreviation: Adv Immunol
publication date: 2014-01-01T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.
PubMed Identifier: 24792912
author list: Shouval DS, Biswas A, Goettel JA, McCann K, Conaway E, Redhu NS, Mascanfroni ID, Al Adham Z, Lavoie S, Ibourk M, Nguyen DD, Samsom JN, Escher JC, Somech R, Weiss B, Beier R, Conklin LS, Ebens CL, Santos FG, Ferreira AR, Sherlock M, Bhan AK, Müller W, Mora JR, Quintana FJ, Klein C, Muise AM, Horwitz BH, Snapper SB
published in: Immunity
information resource reference: Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. Immunity. 2014 May 15; 40(5):706-19.
journal title abbreviation: Immunity
publication date: 2014-05-01T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 730812
type: Authorship
author rank in publication: 28
linked author: Horwitz, Bruce
linked information resource: Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.

Authorship 1778587
type: Authorship
author rank in publication: 4
linked author: Horwitz, Bruce
linked information resource: Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16.

Authorship 1769222
type: Authorship
author rank in publication: 4
linked author: Horwitz, Bruce
linked information resource: Genetic evidence that acute morphologic transformation, induction of cellular DNA synthesis, and focus formation are mediated by a single activity of the bovine papillomavirus E5 protein.

Member of the Faculty of Medicine
is primary position: true
position in department: Medicine
position in division: Experimental Medicine Unit - CCIB
sort order: 1
type: Position
HR job title: Member of the Faculty of Medicine
position in organization: Massachusetts General Hospital

Colonna, Marco
first name: Marco
last name: Colonna
full name: Marco Colonna, M.D.
has faculty rank: Other Faculty
Person ID: 227720
person in primary position: Member of the Faculty of Medicine
type: Agent
type: Person
preferred title: Member of the Faculty of Medicine

Authorship 1788832
type: Authorship
author rank in publication: 1
linked author: Horwitz, Bruce
linked information resource: Transforming activity of a 16-amino-acid segment of the bovine papillomavirus E5 protein linked to random sequences of hydrophobic amino acids.

Authorship 1794113
type: Authorship
author rank in publication: 1
linked author: Horwitz, Bruce
linked information resource: 44-amino-acid E5 transforming protein of bovine papillomavirus requires a hydrophobic core and specific carboxyl-terminal amino acids.

Authorship 1805073
type: Authorship
author rank in publication: 2
linked author: Horwitz, Bruce
linked information resource: The central hydrophobic domain of the bovine papillomavirus E5 transforming protein can be functionally replaced by many hydrophobic amino acid sequences containing a glutamine.

Authorship 1818526
type: Authorship
author rank in publication: 14
linked author: Horwitz, Bruce
linked information resource: Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice.

Transforming activity of a 16-amino-acid segment of the bovine papillomavirus E5 protein linked to random sequences of hydrophobic amino acids.
PubMed Identifier: 2552136
author list: Horwitz BH, Weinstat DL, DiMaio D
published in: Journal of virology
information resource reference: Transforming activity of a 16-amino-acid segment of the bovine papillomavirus E5 protein linked to random sequences of hydrophobic amino acids. J Virol. 1989 Nov; 63(11):4515-9.
journal title abbreviation: J Virol
publication date: 1989-11-01T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice.
PubMed Identifier: 12664076
author list: Horvath TL, Diano S, Miyamoto S, Barry S, Gatti S, Alberati D, Livak F, Lombardi A, Moreno M, Goglia F, Mor G, Hamilton J, Kachinskas D, Horwitz B, Warden CH
published in: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
information resource reference: Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice. Int J Obes Relat Metab Disord. 2003 Apr; 27(4):433-42.
journal title abbreviation: Int J Obes Relat Metab Disord
publication date: 2003-04-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

The central hydrophobic domain of the bovine papillomavirus E5 transforming protein can be functionally replaced by many hydrophobic amino acid sequences containing a glutamine.
PubMed Identifier: 1727496
author list: Kulke R, Horwitz BH, Zibello T, DiMaio D
published in: Journal of virology
information resource reference: The central hydrophobic domain of the bovine papillomavirus E5 transforming protein can be functionally replaced by many hydrophobic amino acid sequences containing a glutamine. J Virol. 1992 Jan; 66(1):505-11.
journal title abbreviation: J Virol
publication date: 1992-01-01T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

44-amino-acid E5 transforming protein of bovine papillomavirus requires a hydrophobic core and specific carboxyl-terminal amino acids.
PubMed Identifier: 2847028
author list: Horwitz BH, Burkhardt AL, Schlegel R, DiMaio D
published in: Molecular and cellular biology
information resource reference: 44-amino-acid E5 transforming protein of bovine papillomavirus requires a hydrophobic core and specific carboxyl-terminal amino acids. Mol Cell Biol. 1988 Oct; 8(10):4071-8.
journal title abbreviation: Mol Cell Biol
publication date: 1988-10-01T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

Gastroenterology & Nutrition
type: Division
type: Organization

Neuroimmunology
type: Division
type: Organization

Samuel L. Wasserstrom Professor of Neurology
is primary position: true
position in department: Neurology
position in division: Neuroimmunology
sort order: 1
type: Position
HR job title: Samuel L. Wasserstrom Professor of Neurology
position in organization: Brigham and Women's Hospital

Authorship 393830
type: Authorship
author rank in publication: 1
linked author: Horwitz, Bruce
linked information resource: Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells.

Authorship 312230
type: Authorship
author rank in publication: 3
linked author: Horwitz, Bruce
linked information resource: NF-kappaB p50 and p65 subunits control intestinal homeostasis.

Authorship 316194
type: Authorship
author rank in publication: 9
linked author: Horwitz, Bruce
linked information resource: Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma.

Egan Family Foundation Professor of Pediatrics in the Field of Transitional Medicine
is primary position: true
position in department: Pediatrics
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Egan Family Foundation Professor of Pediatrics in the Field of Transitional Medicine
position in organization: Boston Children's Hospital

Instructor in Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Genetics
sort order: 1
type: Position
HR job title: Instructor in Pediatrics
position in organization: Boston Children's Hospital

Clinical Fellow in Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Residents
sort order: 1
type: Position
HR job title: Clinical Fellow in Pediatrics
position in organization: Boston Children's Hospital

Professor of Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Immunology
sort order: 1
type: Position
HR job title: Professor of Pediatrics
position in organization: Massachusetts General Hospital

Instructor in Psychiatry
is primary position: true
position in department: Psychiatry
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Instructor in Psychiatry
position in organization: Boston Children's Hospital

Instructor in Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Genetics
sort order: 1
type: Position
HR job title: Instructor in Pediatrics
position in organization: Boston Children's Hospital

Assistant Professor of Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Gastroenterology & Nutrition
sort order: 1
type: Position
HR job title: Assistant Professor of Pediatrics
position in organization: Boston Children's Hospital

Associate Professor of Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Emergency Medicine
sort order: 1
type: Position
HR job title: Associate Professor of Pediatrics
position in organization: Boston Children's Hospital

Associate Professor of Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Cardiology
sort order: 1
type: Position
HR job title: Associate Professor of Pediatrics
position in organization: Boston Children's Hospital

Assistant Professor of Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Genetics
sort order: 1
type: Position
HR job title: Assistant Professor of Pediatrics
position in organization: Boston Children's Hospital

Authorship 542956
type: Authorship
author rank in publication: 9
linked author: Horwitz, Bruce
linked information resource: Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry.

Authorship 559940
type: Authorship
author rank in publication: 3
linked author: Horwitz, Bruce
linked information resource: Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment.

Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.
PubMed Identifier: 25833964
author list: Goettel JA, Biswas S, Lexmond WS, Yeste A, Passerini L, Patel B, Yang S, Sun J, Ouahed J, Shouval DS, McCann KJ, Horwitz BH, Mathis D, Milford EL, Notarangelo LD, Roncarolo MG, Fiebiger E, Marasco WA, Bacchetta R, Quintana FJ, Pai SY, Klein C, Muise AM, Snapper SB
published in: Blood
information resource reference: Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3. Blood. 2015 Jun 18; 125(25):3886-95.
journal title abbreviation: Blood
publication date: 2015-04-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 311380
type: Authorship
author rank in publication: 2
linked author: Horwitz, Bruce
linked information resource: Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB.

Authorship 241286
type: Authorship
author rank in publication: 1
linked author: Horwitz, Bruce
linked information resource: NF-kappa B, an inhibitor of microflora-induced colitis.

Authorship 251144
type: Authorship
author rank in publication: 9
linked author: Horwitz, Bruce
linked information resource: Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus.

Authorship 265572
type: Authorship
author rank in publication: 7
linked author: Horwitz, Bruce
linked information resource: Acute appendicitis is characterized by a uniform and highly selective pattern of inflammatory gene expression.

Authorship 388897
type: Authorship
author rank in publication: 1
linked author: Horwitz, Bruce
linked information resource: Mechanisms of granulocytosis in the absence of CD18.

Authorship 361785
type: Authorship
author rank in publication: 8
linked author: Horwitz, Bruce
linked information resource: NF-kappa B is required within the innate immune system to inhibit microflora-induced colitis and expression of IL-12 p40.

Authorship 40852
type: Authorship
author rank in publication: 4
linked author: Horwitz, Bruce
linked information resource: Nfkb1 inhibits LPS-induced IFN-ß and IL-12 p40 production in macrophages by distinct mechanisms.

Authorship 419360
type: Authorship
author rank in publication: 7
linked author: Horwitz, Bruce
linked information resource: CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice.

Authorship 406457
type: Authorship
author rank in publication: 10
linked author: Horwitz, Bruce
linked information resource: Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B.

Authorship 808005
type: Authorship
author rank in publication: 12
linked author: Horwitz, Bruce
linked information resource: Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.

Authorship 482091
type: Authorship
author rank in publication: 9
linked author: Horwitz, Bruce
linked information resource: CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice.

Authorship 865774
type: Authorship
author rank in publication: 12
linked author: Horwitz, Bruce
linked information resource: O-005 YI Microbiota Drives Inflammation by Altering Intestinal Lamina Propria Macrophage Phenotype in a Novel IL10R-Deficient Model of Very Early Onset IBD.

O-005 YI Microbiota Drives Inflammation by Altering Intestinal Lamina Propria Macrophage Phenotype in a Novel IL10R-Deficient Model of Very Early Onset IBD.
PubMed Identifier: 26849723
author list: Redhu N, Shouval D, Bakthavatchalu V, Wang C, Conaway E, Goettel J, Mack M, Bleich A, Bry L, Fox J, Snapper S, Horwitz B
published in: Inflammatory bowel diseases
information resource reference: O-005 YI Microbiota Drives Inflammation by Altering Intestinal Lamina Propria Macrophage Phenotype in a Novel IL10R-Deficient Model of Very Early Onset IBD. Inflamm Bowel Dis. 2016 Mar; 22 Suppl 1:S2-3.
journal title abbreviation: Inflamm Bowel Dis
publication date: 2016-03-01T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 430359
type: Authorship
author rank in publication: 5
linked author: Horwitz, Bruce
linked information resource: Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses.

Authorship 523168
type: Authorship
author rank in publication: 12
linked author: Horwitz, Bruce
linked information resource: NF-?B1 inhibits TLR-induced IFN-ß production in macrophages through TPL-2-dependent ERK activation.

Assistant Professor
sort order: 2
type: Faculty Rank

Associate Professor
sort order: 1
type: Faculty Rank

Fellow or Post Doc
sort order: 6
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Instructor
sort order: 4
type: Faculty Rank

Other Faculty
sort order: 5
type: Faculty Rank

Authorship 97229
type: Authorship
author rank in publication: 5
linked author: Horwitz, Bruce
linked information resource: Typhlocolitis in NF-kappa B-deficient mice.

Inhibition of Microflora-Induced Colitis by NF-kB
end date: 2012-06-30
principal investigator name: HORWITZ, BRUCE H
start date: 2002-07-01
type: Grant
sponsor award id: R01AI052267

Harvard Skin Disease Research Center
end date: 2011-10-13
principal investigator name: KUPPER, THOMAS S.
start date: 1994-04-01
type: Grant
sponsor award id: P30AR042689

Co-Principal Investigator
type: Researcher Role
researcher role of: Horwitz, Bruce
contributes to: Harvard Skin Disease Research Center

Principal Investigator
type: Researcher Role
researcher role of: Horwitz, Bruce
contributes to: Inhibition of Microflora-Induced Colitis by NF-kB

Interleukin 1ß Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency.
PubMed Identifier: 27693323
author list: Shouval DS, Biswas A, Kang YH, Griffith AE, Konnikova L, Mascanfroni ID, Redhu NS, Frei SM, Field M, Doty AL, Goldsmith JD, Bhan AK, Loizides A, Weiss B, Yerushalmi B, Yanagi T, Lui X, Quintana FJ, Muise AM, Klein C, Horwitz BH, Glover SC, Bousvaros A, Snapper SB
published in: Gastroenterology
information resource reference: Interleukin 1ß Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency. Gastroenterology. 2016 12; 151(6):1100-1104.
journal title abbreviation: Gastroenterology
publication date: 2016-09-28T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 919445
type: Authorship
author rank in publication: 21
linked author: Horwitz, Bruce
linked information resource: Interleukin 1ß Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency.

Authorship 320104
type: Authorship
author rank in publication: 14
linked author: Horwitz, Bruce
linked information resource: Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice.

Authorship 551003
type: Authorship
author rank in publication: 8
linked author: Horwitz, Bruce
linked information resource: Unifying roles for regulatory T cells and inflammation in cancer.

Authorship 958320
type: Authorship
author rank in publication: 5
linked author: Horwitz, Bruce
linked information resource: Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation.

Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation.
PubMed Identifier: 28213503
author list: Conaway EA, de Oliveira DC, McInnis CM, Snapper SB, Horwitz BH
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation. J Immunol. 2017 04 01; 198(7):2906-2915.
journal title abbreviation: J Immunol
publication date: 2017-02-17T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells.
PubMed Identifier: 9208848
author list: Horwitz BH, Scott ML, Cherry SR, Bronson RT, Baltimore D
published in: Immunity
information resource reference: Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells. Immunity. 1997 Jun; 6(6):765-72.
journal title abbreviation: Immunity
publication date: 1997-06-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment.
PubMed Identifier: 11466381
author list: Alcamo E, Mizgerd JP, Horwitz BH, Bronson R, Beg AA, Scott M, Doerschuk CM, Hynes RO, Baltimore D
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment. J Immunol. 2001 Aug 01; 167(3):1592-600.
journal title abbreviation: J Immunol
publication date: 2001-08-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

NF-kappa B is required within the innate immune system to inhibit microflora-induced colitis and expression of IL-12 p40.
PubMed Identifier: 12874241
author list: Tomczak MF, Erdman SE, Poutahidis T, Rogers AB, Holcombe H, Plank B, Fox JG, Horwitz BH
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: NF-kappa B is required within the innate immune system to inhibit microflora-induced colitis and expression of IL-12 p40. J Immunol. 2003 Aug 01; 171(3):1484-92.
journal title abbreviation: J Immunol
publication date: 2003-08-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 969307
type: Authorship
author rank in publication: 16
linked author: Horwitz, Bruce
linked information resource: Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer.

Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer.
PubMed Identifier: 28198364
author list: Wang C, Gong G, Sheh A, Muthupalani S, Bryant EM, Puglisi DA, Holcombe H, Conaway EA, Parry NAP, Bakthavatchalu V, Short SP, Williams CS, Wogan GN, Tannenbaum SR, Fox JG, Horwitz BH
published in: Mucosal immunology
information resource reference: Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer. Mucosal Immunol. 2017 11; 10(6):1504-1517.
journal title abbreviation: Mucosal Immunol
publication date: 2017-02-15T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B.
PubMed Identifier: 17082652
author list: Tomczak MF, Erdman SE, Davidson A, Wang YY, Nambiar PR, Rogers AB, Rickman B, Luchetti D, Fox JG, Horwitz BH
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Inhibition of Helicobacter hepaticus-induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B. J Immunol. 2006 Nov 15; 177(10):7332-9.
journal title abbreviation: J Immunol
publication date: 2006-11-15T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses.
PubMed Identifier: 14515254
author list: Liang SC, Latchman YE, Buhlmann JE, Tomczak MF, Horwitz BH, Freeman GJ, Sharpe AH
published in: European journal of immunology
information resource reference: Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses. Eur J Immunol. 2003 Oct; 33(10):2706-16.
journal title abbreviation: Eur J Immunol
publication date: 2003-10-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

NF-kappaB p50 and p65 subunits control intestinal homeostasis.
PubMed Identifier: 17705134
author list: Gadjeva M, Wang Y, Horwitz BH
published in: European journal of immunology
information resource reference: NF-kappaB p50 and p65 subunits control intestinal homeostasis. Eur J Immunol. 2007 Sep; 37(9):2509-17.
journal title abbreviation: Eur J Immunol
publication date: 2007-09-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Nuclear factor kappa B is required for the development of marginal zone B lymphocytes.
PubMed Identifier: 11034607
author list: Cariappa A, Liou HC, Horwitz BH, Pillai S
published in: The Journal of experimental medicine
information resource reference: Nuclear factor kappa B is required for the development of marginal zone B lymphocytes. J Exp Med. 2000 Oct 16; 192(8):1175-82.
journal title abbreviation: J Exp Med
publication date: 2000-10-16T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

https://connects.catalyst.harvard.edu/Profiles/profile/788383
PubMed Identifier: 14742559
author list: Fox JG, Rogers AB, Whary MT, Ge Z, Taylor NS, Xu S, Horwitz BH, Erdman SE
published in: Infection and immunity
information resource reference: Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains. Infect Immun. 2004 Feb; 72(2):1116-25.
journal title abbreviation: Infect Immun
publication date: 2004-02-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource
label: Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains.

Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB.
PubMed Identifier: 14978013
author list: Dedeoglu F, Horwitz B, Chaudhuri J, Alt FW, Geha RS
published in: International immunology
information resource reference: Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Int Immunol. 2004 Mar; 16(3):395-404.
journal title abbreviation: Int Immunol
publication date: 2004-03-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice.
PubMed Identifier: 12547727
author list: Erdman SE, Poutahidis T, Tomczak M, Rogers AB, Cormier K, Plank B, Horwitz BH, Fox JG
published in: The American journal of pathology
information resource reference: CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice. Am J Pathol. 2003 Feb; 162(2):691-702.
journal title abbreviation: Am J Pathol
publication date: 2003-02-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus.
PubMed Identifier: 16394015
author list: Tomczak MF, Gadjeva M, Wang YY, Brown K, Maroulakou I, Tsichlis PN, Erdman SE, Fox JG, Horwitz BH
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus. J Immunol. 2006 Jan 15; 176(2):1244-51.
journal title abbreviation: J Immunol
publication date: 2006-01-15T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Acute appendicitis is characterized by a uniform and highly selective pattern of inflammatory gene expression.
PubMed Identifier: 19079191
author list: Murphy CG, Glickman JN, Tomczak K, Wang YY, Beggs AH, Shannon MW, Horwitz BH
published in: Mucosal immunology
information resource reference: Acute appendicitis is characterized by a uniform and highly selective pattern of inflammatory gene expression. Mucosal Immunol. 2008 Jul; 1(4):297-308.
journal title abbreviation: Mucosal Immunol
publication date: 2008-07-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry.
PubMed Identifier: 19556024
author list: Kentsis A, Lin YY, Kurek K, Calicchio M, Wang YY, Monigatti F, Campagne F, Lee R, Horwitz B, Steen H, Bachur R
published in: Annals of emergency medicine
information resource reference: Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry. Ann Emerg Med. 2010 Jan; 55(1):62-70.e4.
journal title abbreviation: Ann Emerg Med
publication date: 2009-06-25T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 994358
type: Authorship
author rank in publication: 17
linked author: Horwitz, Bruce
linked information resource: Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor.

Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor.
PubMed Identifier: 28678006
author list: Redhu NS, Bakthavatchalu V, Conaway EA, Shouval DS, Tsou A, Goettel JA, Biswas A, Wang C, Field M, Muller W, Bleich A, Li N, Gerber GK, Bry L, Fox JG, Snapper SB, Horwitz BH
published in: eLife
information resource reference: Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor. Elife. 2017 07 05; 6.
journal title abbreviation: Elife
publication date: 2017-07-05T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Serum markers in acute appendicitis.
PubMed Identifier: 20097375
author list: Allister L, Bachur R, Glickman J, Horwitz B
published in: The Journal of surgical research
information resource reference: Serum markers in acute appendicitis. J Surg Res. 2011 Jun 01; 168(1):70-5.
journal title abbreviation: J Surg Res
publication date: 2009-11-11T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

77 Avenue Louis Pasteur
type: Address
address line 1: Brigham and Women's Hospital
address line 2: Dept. of Pathology, Room 0630-E
address line 3: 77 Avenue Louis Pasteur
city: Boston
postal code: 02115
state or province: MA

A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock.
PubMed Identifier: 15494531
author list: Gadjeva M, Tomczak MF, Zhang M, Wang YY, Dull K, Rogers AB, Erdman SE, Fox JG, Carroll M, Horwitz BH
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock. J Immunol. 2004 Nov 01; 173(9):5786-93.
journal title abbreviation: J Immunol
publication date: 2004-11-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer.
PubMed Identifier: 20944559
author list: Fox JG, Ge Z, Whary MT, Erdman SE, Horwitz BH
published in: Mucosal immunology
information resource reference: Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer. Mucosal Immunol. 2011 Jan; 4(1):22-30.
journal title abbreviation: Mucosal Immunol
publication date: 2010-10-13T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

NF-kappa B, an inhibitor of microflora-induced colitis.
PubMed Identifier: 15805835
author list: Horwitz B
published in: Journal of pediatric gastroenterology and nutrition
information resource reference: NF-kappa B, an inhibitor of microflora-induced colitis. J Pediatr Gastroenterol Nutr. 2005 Apr; 40 Suppl 1:S22-3.
journal title abbreviation: J Pediatr Gastroenterol Nutr
publication date: 2005-04-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Nfkb1 inhibits LPS-induced IFN-ß and IL-12 p40 production in macrophages by distinct mechanisms.
PubMed Identifier: 22427889
author list: Zhao X, Ross EJ, Wang Y, Horwitz BH
published in: PloS one
information resource reference: Nfkb1 inhibits LPS-induced IFN-ß and IL-12 p40 production in macrophages by distinct mechanisms. PLoS One. 2012; 7(3):e32811.
journal title abbreviation: PLoS One
publication date: 2012-03-12T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Unifying roles for regulatory T cells and inflammation in cancer.
PubMed Identifier: 19795459
author list: Erdman SE, Rao VP, Olipitz W, Taylor CL, Jackson EA, Levkovich T, Lee CW, Horwitz BH, Fox JG, Ge Z, Poutahidis T
published in: International journal of cancer
information resource reference: Unifying roles for regulatory T cells and inflammation in cancer. Int J Cancer. 2010 Apr 01; 126(7):1651-65.
journal title abbreviation: Int J Cancer
publication date: 2010-04-01T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

c-Rel is essential for the development of innate and T cell-induced colitis.
PubMed Identifier: 18523276
author list: Wang Y, Rickman BH, Poutahidis T, Schlieper K, Jackson EA, Erdman SE, Fox JG, Horwitz BH
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: c-Rel is essential for the development of innate and T cell-induced colitis. J Immunol. 2008 Jun 15; 180(12):8118-25.
journal title abbreviation: J Immunol
publication date: 2008-06-15T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice.
PubMed Identifier: 14522933
author list: Erdman SE, Rao VP, Poutahidis T, Ihrig MM, Ge Z, Feng Y, Tomczak M, Rogers AB, Horwitz BH, Fox JG
published in: Cancer research
information resource reference: CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice. Cancer Res. 2003 Sep 15; 63(18):6042-50.
journal title abbreviation: Cancer Res
publication date: 2003-09-15T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

The p65 subunit of NF-kappa B is redundant with p50 during B cell proliferative responses, and is required for germline CH transcription and class switching to IgG3.
PubMed Identifier: 9973462
author list: Horwitz BH, Zelazowski P, Shen Y, Wolcott KM, Scott ML, Baltimore D, Snapper CM
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: The p65 subunit of NF-kappa B is redundant with p50 during B cell proliferative responses, and is required for germline CH transcription and class switching to IgG3. J Immunol. 1999 Feb 15; 162(4):1941-6.
journal title abbreviation: J Immunol
publication date: 1999-02-15T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource