Monte Carlo method to study the proton fluence for treatment planning. Med Phys. 1998 Dec; 25(12):2370-5.
Monte Carlo method to study the proton fluence for treatment planning.
Gentile MS, Yeap BY, Paganetti H, Goebel CP, Gaudet DE, Gallotto SL, Weyman EA, Morgan ML, MacDonald SM, Giantsoudi D, Adams J, Tarbell NJ, Kooy H, Yock TI
International journal of radiation oncology, biology, physics
Brainstem Injury in Pediatric Patients With Posterior Fossa Tumors Treated With Proton Beam Therapy and Associated Dosimetric Factors. Int J Radiat Oncol Biol Phys. 2018 03 01; 100(3):719-729.
Brainstem Injury in Pediatric Patients With Posterior Fossa Tumors Treated With Proton Beam Therapy and Associated Dosimetric Factors.
Haas-Kogan D, Indelicato D, Paganetti H, Esiashvili N, Mahajan A, Yock T, Flampouri S, MacDonald S, Fouladi M, Stephen K, Kalapurakal J, Terezakis S, Kooy H, Grosshans D, Makrigiorgos M, Mishra K, Poussaint TY, Cohen K, Fitzgerald T, Gondi V, Liu A, Michalski J, Mirkovic D, Mohan R, Perkins S, Wong K, Vikram B, Buchsbaum J, Kun L
National Cancer Institute Workshop on Proton Therapy for Children: Considerations Regarding Brainstem Injury. Int J Radiat Oncol Biol Phys. 2018 05 01; 101(1):152-168.
National Cancer Institute Workshop on Proton Therapy for Children: Considerations Regarding Brainstem Injury.
Seco J, Sharp GC, Wu Z, Gierga D, Buettner F, Paganetti H
Dosimetric impact of motion in free-breathing and gated lung radiotherapy: a 4D Monte Carlo study of intrafraction and interfraction effects. Med Phys. 2008 Jan; 35(1):356-66.
Dosimetric impact of motion in free-breathing and gated lung radiotherapy: a 4D Monte Carlo study of intrafraction and interfraction effects.
Risk of developing second cancer from neutron dose in proton therapy as function of field characteristics, organ, and patient age. Int J Radiat Oncol Biol Phys. 2008 Sep 01; 72(1):228-35.
Risk of developing second cancer from neutron dose in proton therapy as function of field characteristics, organ, and patient age.
Dose to water versus dose to medium in proton beam therapy. Phys Med Biol. 2009 Jul 21; 54(14):4399-421.
Dose to water versus dose to medium in proton beam therapy.
Ramos-Méndez J, Perl J, Schuemann J, McNamara A, Paganetti H, Faddegon B
Monte Carlo simulation of chemistry following radiolysis with TOPAS-nBio. Phys Med Biol. 2018 05 17; 63(10):105014.
Monte Carlo simulation of chemistry following radiolysis with TOPAS-nBio.
Uncertainties in planned dose due to the limited voxel size of the planning CT when treating lung tumors with proton therapy. Phys Med Biol. 2011 Jul 07; 56(13):3843-56.
Uncertainties in planned dose due to the limited voxel size of the planning CT when treating lung tumors with proton therapy.
Moteabbed M, Geyer A, Drenkhahn R, Bolch WE, Paganetti H
Comparison of whole-body phantom designs to estimate organ equivalent neutron doses for secondary cancer risk assessment in proton therapy. Phys Med Biol. 2012 Jan 21; 57(2):499-515.
Comparison of whole-body phantom designs to estimate organ equivalent neutron doses for secondary cancer risk assessment in proton therapy.
Giantsoudi D, Adams J, MacDonald S, Paganetti H
Can differences in linear energy transfer and thus relative biological effectiveness compromise the dosimetric advantage of intensity-modulated proton therapy as compared to passively scattered proton therapy? Acta Oncol. 2018 Sep; 57(9):1259-1264.
Can differences in linear energy transfer and thus relative biological effectiveness compromise the dosimetric advantage of intensity-modulated proton therapy as compared to passively scattered proton therapy?
Parodi K, Paganetti H, Shih HA, Michaud S, Loeffler JS, DeLaney TF, Liebsch NJ, Munzenrider JE, Fischman AJ, Knopf A, Bortfeld T
Patient study of in vivo verification of beam delivery and range, using positron emission tomography and computed tomography imaging after proton therapy. Int J Radiat Oncol Biol Phys. 2007 Jul 01; 68(3):920-34.
Patient study of in vivo verification of beam delivery and range, using positron emission tomography and computed tomography imaging after proton therapy.
Parodi K, Ferrari A, Sommerer F, Paganetti H
Clinical CT-based calculations of dose and positron emitter distributions in proton therapy using the FLUKA Monte Carlo code. Phys Med Biol. 2007 Jun 21; 52(12):3369-87.
Clinical CT-based calculations of dose and positron emitter distributions in proton therapy using the FLUKA Monte Carlo code.
Varying relative biological effectiveness in proton therapy: knowledge gaps versus clinical significance. Acta Oncol. 2017 Jun; 56(6):761-762.
Varying relative biological effectiveness in proton therapy: knowledge gaps versus clinical significance.
Robust Proton Treatment Planning: Physical and Biological Optimization. Semin Radiat Oncol. 2018 04; 28(2):88-96.
Robust Proton Treatment Planning: Physical and Biological Optimization.
Neutron dose in proton radiation therapy: in regard to Eric J. Hall (Int J Radiat Oncol Biol Phys 2006;65:1-7). Int J Radiat Oncol Biol Phys. 2006 Dec 01; 66(5):1594-5; author reply 1595.
Neutron dose in proton radiation therapy: in regard to Eric J. Hall (Int J Radiat Oncol Biol Phys 2006;65:1-7).
Suit H, Goldberg S, Niemierko A, Ancukiewicz M, Hall E, Goitein M, Wong W, Paganetti H
Secondary carcinogenesis in patients treated with radiation: a review of data on radiation-induced cancers in human, non-human primate, canine and rodent subjects. Radiat Res. 2007 Jan; 167(1):12-42.
Secondary carcinogenesis in patients treated with radiation: a review of data on radiation-induced cancers in human, non-human primate, canine and rodent subjects.
Seco J, Robertson D, Trofimov A, Paganetti H
Breathing interplay effects during proton beam scanning: simulation and statistical analysis. Phys Med Biol. 2009 Jul 21; 54(14):N283-94.
Breathing interplay effects during proton beam scanning: simulation and statistical analysis.
Attanasi F, Knopf A, Parodi K, Paganetti H, Bortfeld T, Rosso V, Del Guerra A
Extension and validation of an analytical model for in vivo PET verification of proton therapy--a phantom and clinical study. Phys Med Biol. 2011 Aug 21; 56(16):5079-98.
Extension and validation of an analytical model for in vivo PET verification of proton therapy--a phantom and clinical study.
Rinaldi I, Ferrari A, Mairani A, Paganetti H, Parodi K, Sala P
An integral test of FLUKA nuclear models with 160 MeV proton beams in multi-layer Faraday cups. Phys Med Biol. 2011 Jul 07; 56(13):4001-11.
An integral test of FLUKA nuclear models with 160 MeV proton beams in multi-layer Faraday cups.
Relative Biological Effectiveness Uncertainties and Implications for Beam Arrangements and Dose Constraints in Proton Therapy. Semin Radiat Oncol. 2018 06; 28(3):256-263.
Relative Biological Effectiveness Uncertainties and Implications for Beam Arrangements and Dose Constraints in Proton Therapy.
Carabe A, España S, Grassberger C, Paganetti H
Clinical consequences of relative biological effectiveness variations in proton radiotherapy of the prostate, brain and liver. Phys Med Biol. 2013 Apr 07; 58(7):2103-17.
Clinical consequences of relative biological effectiveness variations in proton radiotherapy of the prostate, brain and liver.
Underwood TSA, Grassberger C, Bass R, MacDonald SM, Meyersohn NM, Yeap BY, Jimenez RB, Paganetti H
Asymptomatic Late-phase Radiographic Changes Among Chest-Wall Patients Are Associated With a Proton RBE Exceeding 1.1. Int J Radiat Oncol Biol Phys. 2018 07 15; 101(4):809-819.
Asymptomatic Late-phase Radiographic Changes Among Chest-Wall Patients Are Associated With a Proton RBE Exceeding 1.1.
Carabe-Fernandez A, Dale RG, Hopewell JW, Jones B, Paganetti H
Fractionation effects in particle radiotherapy: implications for hypo-fractionation regimes. Phys Med Biol. 2010 Oct 07; 55(19):5685-700.
Fractionation effects in particle radiotherapy: implications for hypo-fractionation regimes.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Comparison of second cancer risk due to out-of-field doses from 6-MV IMRT and proton therapy based on 6 pediatric patient treatment plans. Radiother Oncol. 2011 Jan; 98(1):87-92.
Comparison of second cancer risk due to out-of-field doses from 6-MV IMRT and proton therapy based on 6 pediatric patient treatment plans.
Zhu X, España S, Daartz J, Liebsch N, Ouyang J, Paganetti H, Bortfeld TR, El Fakhri G
Monitoring proton radiation therapy with in-room PET imaging. Phys Med Biol. 2011 Jul 07; 56(13):4041-57.
Monitoring proton radiation therapy with in-room PET imaging.
Assessment of the risk for developing a second malignancy from scattered and secondary radiation in radiation therapy. Health Phys. 2012 Nov; 103(5):652-61.
Assessment of the risk for developing a second malignancy from scattered and secondary radiation in radiation therapy.
Suit H, Goldberg S, Niemierko A, Trofimov A, Adams J, Paganetti H, Chen GT, Bortfeld T, Rosenthal S, Loeffler J, Delaney T
Proton beams to replace photon beams in radical dose treatments. Acta Oncol. 2003; 42(8):800-8.
Proton beams to replace photon beams in radical dose treatments.
Parodi K, Paganetti H, Cascio E, Flanz JB, Bonab AA, Alpert NM, Lohmann K, Bortfeld T
PET/CT imaging for treatment verification after proton therapy: a study with plastic phantoms and metallic implants. Med Phys. 2007 Feb; 34(2):419-35.
PET/CT imaging for treatment verification after proton therapy: a study with plastic phantoms and metallic implants.
Sarfehnia A, Clasie B, Chung E, Lu HM, Flanz J, Cascio E, Engelsman M, Paganetti H, Seuntjens J
Direct absorbed dose to water determination based on water calorimetry in scanning proton beam delivery. Med Phys. 2010 Jul; 37(7):3541-50.
Direct absorbed dose to water determination based on water calorimetry in scanning proton beam delivery.
Technology in cancer research & treatment
The impact of protons on the incidence of second malignancies in radiotherapy by Eric J. Hall; Supp.31-34 2007. Technol Cancer Res Treat. 2007 Dec; 6(6):661-2.
The impact of protons on the incidence of second malignancies in radiotherapy by Eric J. Hall; Supp.31-34 2007.
Range uncertainties in proton therapy and the role of Monte Carlo simulations. Phys Med Biol. 2012 Jun 07; 57(11):R99-117.
Range uncertainties in proton therapy and the role of Monte Carlo simulations.
McNamara AL, Ramos-Méndez J, Perl J, Held K, Dominguez N, Moreno E, Henthorn NT, Kirkby KJ, Meylan S, Villagrasa C, Incerti S, Faddegon B, Paganetti H, Schuemann J
Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit. Phys Med Biol. 2018 09 06; 63(17):175018.
Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit.
Author Correction: Prediction of Treatment Response for Combined Chemo- and Radiation Therapy for Non-Small Cell Lung Cancer Patients Using a Bio-Mathematical Model. Sci Rep. 2018 Aug 17; 8(1):12631.
Author Correction: Prediction of Treatment Response for Combined Chemo- and Radiation Therapy for Non-Small Cell Lung Cancer Patients Using a Bio-Mathematical Model.
McGurk R, Seco J, Riboldi M, Wolfgang J, Segars P, Paganetti H
Extension of the NCAT phantom for the investigation of intra-fraction respiratory motion in IMRT using 4D Monte Carlo. Phys Med Biol. 2010 Mar 07; 55(5):1475-90.
Extension of the NCAT phantom for the investigation of intra-fraction respiratory motion in IMRT using 4D Monte Carlo.
Schümann J, Paganetti H, Shin J, Faddegon B, Perl J
Efficient voxel navigation for proton therapy dose calculation in TOPAS and Geant4. Phys Med Biol. 2012 Jun 07; 57(11):3281-93.
Efficient voxel navigation for proton therapy dose calculation in TOPAS and Geant4.
Chen Y, Grassberger C, Li J, Hong TS, Paganetti H
Impact of potentially variable RBE in liver proton therapy. Phys Med Biol. 2018 09 21; 63(19):195001.
Impact of potentially variable RBE in liver proton therapy.
Bednarz B, Lu HM, Engelsman M, Paganetti H
Uncertainties and correction methods when modeling passive scattering proton therapy treatment heads with Monte Carlo. Phys Med Biol. 2011 May 07; 56(9):2837-54.
Uncertainties and correction methods when modeling passive scattering proton therapy treatment heads with Monte Carlo.
Carabe A, Moteabbed M, Depauw N, Schuemann J, Paganetti H
Range uncertainty in proton therapy due to variable biological effectiveness. Phys Med Biol. 2012 Mar 07; 57(5):1159-72.
Range uncertainty in proton therapy due to variable biological effectiveness.
Shin J, Perl J, Schümann J, Paganetti H, Faddegon BA
A modular method to handle multiple time-dependent quantities in Monte Carlo simulations. Phys Med Biol. 2012 Jun 07; 57(11):3295-308.
A modular method to handle multiple time-dependent quantities in Monte Carlo simulations.
Perl J, Shin J, Schumann J, Faddegon B, Paganetti H
TOPAS: an innovative proton Monte Carlo platform for research and clinical applications. Med Phys. 2012 Nov; 39(11):6818-37.
TOPAS: an innovative proton Monte Carlo platform for research and clinical applications.
Tucker SL, Xu T, Paganetti H, Deist T, Verma V, Choi N, Mohan R, Liao Z
Validation of Effective Dose as a Better Predictor of Radiation Pneumonitis Risk Than Mean Lung Dose: Secondary Analysis of a Randomized Trial. Int J Radiat Oncol Biol Phys. 2019 02 01; 103(2):403-410.
Validation of Effective Dose as a Better Predictor of Radiation Pneumonitis Risk Than Mean Lung Dose: Secondary Analysis of a Randomized Trial.
Paganetti H, Jiang H, Parodi K, Slopsema R, Engelsman M
Clinical implementation of full Monte Carlo dose calculation in proton beam therapy. Phys Med Biol. 2008 Sep 07; 53(17):4825-53.
Clinical implementation of full Monte Carlo dose calculation in proton beam therapy.
Riboldi M, Chen GT, Baroni G, Paganetti H, Seco J
Design and testing of a simulation framework for dosimetric motion studies integrating an anthropomorphic computational phantom into four-dimensional Monte Carlo. Technol Cancer Res Treat. 2008 Dec; 7(6):449-56.
Design and testing of a simulation framework for dosimetric motion studies integrating an anthropomorphic computational phantom into four-dimensional Monte Carlo.
International journal of particle therapy
Proton Relative Biological Effectiveness - Uncertainties and Opportunities. Int J Part Ther. 2018; 5(1):2-14.
Proton Relative Biological Effectiveness - Uncertainties and Opportunities.
LET-weighted doses effectively reduce biological variability in proton radiotherapy planning. Phys Med Biol. 2018 11 09; 63(22):225009.
LET-weighted doses effectively reduce biological variability in proton radiotherapy planning.
Schuemann J, McNamara AL, Warmenhoven JW, Henthorn NT, Kirkby KJ, Merchant MJ, Ingram S, Paganetti H, Held KD, Ramos-Mendez J, Faddegon B, Perl J, Goodhead DT, Plante I, Rabus H, Nettelbeck H, Friedland W, Kundrát P, Ottolenghi A, Baiocco G, Barbieri S, Dingfelder M, Incerti S, Villagrasa C, Bueno M, Bernal MA, Guatelli S, Sakata D, Brown JMC, Francis Z, Kyriakou I, Lampe N, Ballarini F, Carante MP, Davídková M, Štepán V, Jia X, Cucinotta FA, Schulte R, Stewart RD, Carlson DJ, Galer S, Kuncic Z, Lacombe S, Milligan J, Cho SH, Sawakuchi G, Inaniwa T, Sato T, Li W, Solov'yov AV, Surdutovich E, Durante M, Prise KM, McMahon SJ
A New Standard DNA Damage (SDD) Data Format. Radiat Res. 2019 01; 191(1):76-92.
A New Standard DNA Damage (SDD) Data Format.
The biologic relevance of daily dose variations in adaptive treatment planning. Int J Radiat Oncol Biol Phys. 2006 Jul 01; 65(3):899-906.
The biologic relevance of daily dose variations in adaptive treatment planning.
Online adaption approaches for intensity modulated proton therapy for head and neck patients based on cone beam CTs and Monte Carlo simulations. Phys Med Biol. 2018 12 19; 64(1):015004.
Online adaption approaches for intensity modulated proton therapy for head and neck patients based on cone beam CTs and Monte Carlo simulations.
Brenner DJ, Elliston CD, Hall EJ, Paganetti H
Reduction of the secondary neutron dose in passively scattered proton radiotherapy, using an optimized pre-collimator/collimator. Phys Med Biol. 2009 Oct 21; 54(20):6065-78.
Reduction of the secondary neutron dose in passively scattered proton radiotherapy, using an optimized pre-collimator/collimator.
Proton therapy physics. Med Phys. 2013 Jan; 40(1):017301.
Schuemann J, McNamara AL, Ramos-Méndez J, Perl J, Held KD, Paganetti H, Incerti S, Faddegon B
TOPAS-nBio: An Extension to the TOPAS Simulation Toolkit for Cellular and Sub-cellular Radiobiology. Radiat Res. 2019 02; 191(2):125-138.
TOPAS-nBio: An Extension to the TOPAS Simulation Toolkit for Cellular and Sub-cellular Radiobiology.
Durante M, Paganetti H, Pompos A, Kry SF, Wu X, Grosshans DR
Report of a National Cancer Institute special panel: Characterization of the physical parameters of particle beams for biological research. Med Phys. 2019 Feb; 46(2):e37-e52.
Report of a National Cancer Institute special panel: Characterization of the physical parameters of particle beams for biological research.
Foreword: Hadron therapy--from yesterday's physics laboratory to today's modern clinical routine. Technol Cancer Res Treat. 2003 Oct; 2(5):353-4.
Foreword: Hadron therapy--from yesterday's physics laboratory to today's modern clinical routine.
Paganetti H, Blakely E, Carabe-Fernandez A, Carlson DJ, Das IJ, Dong L, Grosshans D, Held KD, Mohan R, Moiseenko V, Niemierko A, Stewart RD, Willers H
Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy. Med Phys. 2019 Mar; 46(3):e53-e78.
Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy.
Fast Individualized Delivery Adaptation in Proton Therapy
Radiotherapy Planning, Computer-Assisted
Li Y, Dykstra M, Best TD, Pursley J, Chopra N, Keane FK, Khandekar MJ, Sharp GC, Paganetti H, Willers H, Fintelmann FJ, Grassberger C
Differential inflammatory response dynamics in normal lung following stereotactic body radiation therapy with protons versus photons. Radiother Oncol. 2019 07; 136:169-175.
Differential inflammatory response dynamics in normal lung following stereotactic body radiation therapy with protons versus photons.
Oesten H, Neubeck CV, Jakob A, Enghardt W, Krause M, McMahon SJ, Grassberger C, Paganetti H, Lühr A
Predicting In Vitro Cancer Cell Survival Based on Measurable Cell Characteristics. Radiat Res. 2019 06; 191(6):532-544.
Predicting In Vitro Cancer Cell Survival Based on Measurable Cell Characteristics.
Assistant Professor of Radiation Oncology
Applying a variable relative biological effectiveness (RBE) might affect the analysis of clinical trials comparing photon and proton therapy for prostate cancer. Phys Med Biol. 2019 06 05; 64(11):115027.
Applying a variable relative biological effectiveness (RBE) might affect the analysis of clinical trials comparing photon and proton therapy for prostate cancer.
Grassberger C, McClatchy D, Geng C, Kamran SC, Fintelmann F, Maruvka YE, Piotrowska Z, Willers H, Sequist LV, Hata AN, Paganetti H
Patient-Specific Tumor Growth Trajectories Determine Persistent and Resistant Cancer Cell Populations during Treatment with Targeted Therapies. Cancer Res. 2019 07 15; 79(14):3776-3788.
Patient-Specific Tumor Growth Trajectories Determine Persistent and Resistant Cancer Cell Populations during Treatment with Targeted Therapies.
Zhu H, Chen Y, Sung W, McNamara AL, Tran LT, Burigo LN, Rosenfeld AB, Li J, Faddegon B, Schuemann J, Paganetti H
The microdosimetric extension in TOPAS: development and comparison with published data. Phys Med Biol. 2019 07 11; 64(14):145004.
The microdosimetric extension in TOPAS: development and comparison with published data.
Associate Professor of Radiation Oncology
Instructor in Radiation Oncology, Part-time
Meschini G, Seregni M, Molinelli S, Vai A, Phillips J, Sharp GC, Pella A, Valvo F, Ciocca M, Riboldi M, Paganetti H, Baroni G
Validation of a model for physical dose variations in irregularly moving targets treated with carbon ion beams. Med Phys. 2019 Aug; 46(8):3663-3673.
Validation of a model for physical dose variations in irregularly moving targets treated with carbon ion beams.
Andres Soriano Professor of Radiation Oncology
Abhyankar YS, Dev S, Sarun OS, Saxena A, Joshi R, Darbari H, Sajish C, Sonavane UB, Gavane V, Deshpande A, Dixit T, Harsh R, Badwe R, Rath GK, Laskar S, Faddegon B, Perl J, Paganetti H, Schuemann J, Srivastava A, Obcemea C, Nath AK, Sharma A, Buchsbaum J
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
Monte Carlo Processing on a Chip (MCoaC)-preliminary experiments toward the realization of optimal-hardware for TOPAS/Geant4 to drive discovery. Phys Med. 2019 Aug; 64:166-173.
Monte Carlo Processing on a Chip (MCoaC)-preliminary experiments toward the realization of optimal-hardware for TOPAS/Geant4 to drive discovery.
Marteinsdottir M, Schuemann J, Paganetti H
Impact of uncertainties in range and RBE on small field proton therapy. Phys Med Biol. 2019 10 10; 64(20):205005.
Impact of uncertainties in range and RBE on small field proton therapy.
Niyazi M, Niemierko A, Paganetti H, Söhn M, Schapira E, Goldberg S, Adams J, Kim V, Oh KS, Hwang WL, Lu HM, Belka C, Busse PM, Loeffler JS, Shih HA
Volumetric and actuarial analysis of brain necrosis in proton therapy using a novel mixture cure model. Radiother Oncol. 2020 01; 142:154-161.
Volumetric and actuarial analysis of brain necrosis in proton therapy using a novel mixture cure model.
Gjesteby L, Shan H, Yang Q, Xi Y, Jin Y, Giantsoudi D, Paganetti H, De Man B, Wang G
A dual-stream deep convolutional network for reducing metal streak artifacts in CT images. Phys Med Biol. 2019 11 26; 64(23):235003.
A dual-stream deep convolutional network for reducing metal streak artifacts in CT images.
Modelling variable proton relative biological effectiveness for treatment planning. Br J Radiol. 2020 Mar; 93(1107):20190334.
Modelling variable proton relative biological effectiveness for treatment planning.
Newpower M, Schuemann J, Mohan R, Paganetti H, Titt U
Comparing 2 Monte Carlo Systems in Use for Proton Therapy Research. Int J Part Ther. 2019; 6(1):18-27.
Comparing 2 Monte Carlo Systems in Use for Proton Therapy Research.
Zhu H, McNamara AL, Ramos-Mendez J, McMahon SJ, Henthorn NT, Faddegon B, Held KD, Perl J, Li J, Paganetti H, Schuemann J
A parameter sensitivity study for simulating DNA damage after proton irradiation using TOPAS-nBio. Phys Med Biol. 2020 04 23; 65(8):085015.
A parameter sensitivity study for simulating DNA damage after proton irradiation using TOPAS-nBio.
4D blood flow model for dose calculation to circulating blood and lymphocytes. Phys Med Biol. 2020 03 02; 65(5):055008.
4D blood flow model for dose calculation to circulating blood and lymphocytes.
Meschini G, Kamp F, Hofmaier J, Reiner M, Sharp G, Paganetti H, Belka C, Wilkens JJ, Carlson DJ, Parodi K, Baroni G, Riboldi M
Modeling RBE-weighted dose variations in irregularly moving abdominal targets treated with carbon ion beams. Med Phys. 2020 Jul; 47(7):2768-2778.
Modeling RBE-weighted dose variations in irregularly moving abdominal targets treated with carbon ion beams.
McNamara AL, Hall DC, Shusharina N, Liu A, Wei X, Ajdari A, Mohan R, Liao Z, Paganetti H
Perspectives on the model-based approach to proton therapy trials: A retrospective study of a lung cancer randomized trial. Radiother Oncol. 2020 06; 147:8-14.
Perspectives on the model-based approach to proton therapy trials: A retrospective study of a lung cancer randomized trial.
Wang CC, McNamara AL, Shin J, Schuemann J, Grassberger C, Taghian AG, Jimenez RB, MacDonald SM, Paganetti H
End-of-Range Radiobiological Effect on Rib Fractures in Patients Receiving Proton Therapy for Breast Cancer. Int J Radiat Oncol Biol Phys. 2020 07 01; 107(3):449-454.
End-of-Range Radiobiological Effect on Rib Fractures in Patients Receiving Proton Therapy for Breast Cancer.
Faddegon B, Ramos-Méndez J, Schuemann J, McNamara A, Shin J, Perl J, Paganetti H
The TOPAS tool for particle simulation, a Monte Carlo simulation tool for physics, biology and clinical research. Phys Med. 2020 Apr; 72:114-121.
The TOPAS tool for particle simulation, a Monte Carlo simulation tool for physics, biology and clinical research.
DICOM-RT Ion interface to utilize MC simulations in routine clinical workflow for proton pencil beam radiotherapy. Phys Med. 2020 06; 74:1-10.
DICOM-RT Ion interface to utilize MC simulations in routine clinical workflow for proton pencil beam radiotherapy.
Assessing second cancer risk after primary cancer treatment with photon or proton radiotherapy. Cancer. 2020 08 01; 126(15):3397-3399.
Assessing second cancer risk after primary cancer treatment with photon or proton radiotherapy.
Zhu H, McNamara AL, McMahon SJ, Ramos-Mendez J, Henthorn NT, Faddegon B, Held KD, Perl J, Li J, Paganetti H, Schuemann J
Cellular Response to Proton Irradiation: A Simulation Study with TOPAS-nBio. Radiat Res. 2020 07 08; 194(1):9-21.
Cellular Response to Proton Irradiation: A Simulation Study with TOPAS-nBio.
Paganetti H, Depauw N, Johnson A, Forman RB, Lau J, Jimenez R
The risk for developing a secondary cancer after breast radiation therapy: Comparison of photon and proton techniques. Radiother Oncol. 2020 08; 149:212-218.
The risk for developing a secondary cancer after breast radiation therapy: Comparison of photon and proton techniques.
Lalonde A, Winey B, Verburg J, Paganetti H, Sharp GC
Evaluation of CBCT scatter correction using deep convolutional neural networks for head and neck adaptive proton therapy. Phys Med Biol. 2020 12 04; 65(24).
Evaluation of CBCT scatter correction using deep convolutional neural networks for head and neck adaptive proton therapy.
Developing whole-body computational phantoms for blood dosimetry to model the impact of radiation on the immune system
Sung W, Grassberger C, McNamara AL, Basler L, Ehrbar S, Tanadini-Lang S, Hong TS, Paganetti H
A tumor-immune interaction model for hepatocellular carcinoma based on measured lymphocyte counts in patients undergoing radiotherapy. Radiother Oncol. 2020 10; 151:73-81.
A tumor-immune interaction model for hepatocellular carcinoma based on measured lymphocyte counts in patients undergoing radiotherapy.
Niemierko A, Schuemann J, Niyazi M, Giantsoudi D, Maquilan G, Shih HA, Paganetti H
Brain Necrosis in Adult Patients After Proton Therapy: Is There Evidence for Dependency on Linear Energy Transfer? Int J Radiat Oncol Biol Phys. 2021 01 01; 109(1):109-119.
Brain Necrosis in Adult Patients After Proton Therapy: Is There Evidence for Dependency on Linear Energy Transfer?
McClatchy DM, Willers H, Hata AN, Piotrowska Z, Sequist LV, Paganetti H, Grassberger C
Modeling Resistance and Recurrence Patterns of Combined Targeted-Chemoradiotherapy Predicts Benefit of Shorter Induction Period. Cancer Res. 2020 11 15; 80(22):5121-5133.
Modeling Resistance and Recurrence Patterns of Combined Targeted-Chemoradiotherapy Predicts Benefit of Shorter Induction Period.
"Cancer risk after breast proton therapy considering physiological and radiobiological uncertainties" by Raptis et al. (Physica Medica 76 (2020) 1-6). Phys Med. 2020 Dec; 80:274-276.
"Cancer risk after breast proton therapy considering physiological and radiobiological uncertainties" by Raptis et al. (Physica Medica 76 (2020) 1-6).
Paganetti H, Beltran C, Both S, Dong L, Flanz J, Furutani K, Grassberger C, Grosshans DR, Knopf AC, Langendijk JA, Nystrom H, Parodi K, Raaymakers BW, Richter C, Sawakuchi GO, Schippers M, Shaitelman SF, Teo BKK, Unkelbach J, Wohlfahrt P, Lomax T
Roadmap: proton therapy physics and biology. Phys Med Biol. 2021 02 26; 66(5).
Roadmap: proton therapy physics and biology.
Journal of nanoscience and nanotechnology
Study on the Effect and Mechanism of Paclitaxel-Succini Acid Drug-Loaded Nanofibers in Treating Lung Cancer. J Nanosci Nanotechnol. 2021 Feb 01; 21(2):909-913.
Study on the Effect and Mechanism of Paclitaxel-Succini Acid Drug-Loaded Nanofibers in Treating Lung Cancer.
Marteinsdottir M, Wang CC, McNamara AL, Depauw N, Shin J, Paganetti H
The impact of variable RBE in proton therapy for left-sided breast cancer when estimating normal tissue complications in the heart and lung. Phys Med Biol. 2020 Dec 09.
The impact of variable RBE in proton therapy for left-sided breast cancer when estimating normal tissue complications in the heart and lung.
Bobic M, Lalonde A, Sharp GC, Grassberger C, Verburg JM, Winey BA, Lomax AJ, Paganetti H
Comparison of weekly and daily online adaptation for head and neck intensity-modulated proton therapy. Phys Med Biol. 2021 02 25; 66(5).
Comparison of weekly and daily online adaptation for head and neck intensity-modulated proton therapy.
Marteinsdottir M, Wang CC, McNamara A, Depauw N, Shin J, Paganetti H
The impact of variable relative biological effectiveness in proton therapy for left-sided breast cancer when estimating normal tissue complications in the heart and lung. Phys Med Biol. 2021 01 30; 66(3):035023.
The impact of variable relative biological effectiveness in proton therapy for left-sided breast cancer when estimating normal tissue complications in the heart and lung.
Zhang YY, Huo WL, Goldberg SI, Slater JM, Adams JA, Deng XW, Sun Y, Ma J, Fullerton BC, Paganetti H, Loeffler JS, Lu HM, Chan AW
Brain-Specific Relative Biological Effectiveness of Protons Based on Long-term Outcome of Patients With Nasopharyngeal Carcinoma. Int J Radiat Oncol Biol Phys. 2021 Jul 15; 110(4):984-992.
Brain-Specific Relative Biological Effectiveness of Protons Based on Long-term Outcome of Patients With Nasopharyngeal Carcinoma.
Physics of Particle Beam and Hypofractionated Beam Delivery in NSCLC. Semin Radiat Oncol. 2021 04; 31(2):162-169.
Physics of Particle Beam and Hypofractionated Beam Delivery in NSCLC.
Lalonde A, Bobic M, Winey B, Verburg J, Sharp GC, Paganetti H
Anatomic changes in head and neck intensity-modulated proton therapy: Comparison between robust optimization and online adaptation. Radiother Oncol. 2021 06; 159:39-47.
Anatomic changes in head and neck intensity-modulated proton therapy: Comparison between robust optimization and online adaptation.
Erratum: Evaluation of CBCT scatter correction using deep convolutional neural networks for head and neck adaptive proton therapy (2020Phys. Med. Biol.65245022). Phys Med Biol. 2021 Jun 30; 66(13).
Erratum: Evaluation of CBCT scatter correction using deep convolutional neural networks for head and neck adaptive proton therapy (2020Phys. Med. Biol.65245022).
Bertolet A, Ramos-Méndez J, Paganetti H, Schuemann J
The relation between microdosimetry and induction of direct damage to DNA by alpha particles. Phys Med Biol. 2021 07 30; 66(15).
The relation between microdosimetry and induction of direct damage to DNA by alpha particles.
Shin J, Xing S, McCullum L, Hammi A, Pursley J, Correa CA, Withrow J, Domal S, Bolch W, Paganetti H, Grassberger C
HEDOS-a computational tool to assess radiation dose to circulating blood cells during external beam radiotherapy based on whole-body blood flow simulations. Phys Med Biol. 2021 08 03; 66(16).
HEDOS-a computational tool to assess radiation dose to circulating blood cells during external beam radiotherapy based on whole-body blood flow simulations.
Wang L, Fossati P, Paganetti H, Ma L, Gillison M, Myers JN, Hug E, Frank SJ
The Biological Basis for Enhanced Effects of Proton Radiation Therapy Relative to Photon Radiation Therapy for Head and Neck Squamous Cell Carcinoma. Int J Part Ther. 2021; 8(1):3-13.
The Biological Basis for Enhanced Effects of Proton Radiation Therapy Relative to Photon Radiation Therapy for Head and Neck Squamous Cell Carcinoma.
Moteabbed M, Harisinghani M, Paganetti H, Trofimov A, Lu HM, Efstathiou JA
Proton vs. photon radiotherapy for MR-guided dose escalation of intraprostatic lesions. Acta Oncol. 2021 Oct; 60(10):1283-1290.
Proton vs. photon radiotherapy for MR-guided dose escalation of intraprostatic lesions.
Park H, Paganetti H, Schuemann J, Jia X, Min CH
Monte Carlo methods for device simulations in radiation therapy. Phys Med Biol. 2021 09 14; 66(18).
Monte Carlo methods for device simulations in radiation therapy.
Ramos-Méndez J, LaVerne JA, Domínguez-Kondo N, Milligan J, Štepán V, Stefanová K, Perrot Y, Villagrasa C, Shin WG, Incerti S, McNamara A, Paganetti H, Perl J, Schuemann J, Faddegon B
TOPAS-nBio validation for simulating water radiolysis and DNA damage under low-LET irradiation. Phys Med Biol. 2021 09 03; 66(17).
TOPAS-nBio validation for simulating water radiolysis and DNA damage under low-LET irradiation.
Mechanisms and Review of Clinical Evidence of Variations in Relative Biological Effectiveness in Proton Therapy. Int J Radiat Oncol Biol Phys. 2022 01 01; 112(1):222-236.
Mechanisms and Review of Clinical Evidence of Variations in Relative Biological Effectiveness in Proton Therapy.
Constrained Disentanglement (CODE) Network for CT Metal Artifact Reduction in Radiation Therapy
Integrating patient-specific clinical and biological factors towards individualizing utilization of proton and photon radiation therapy.
Adaptive proton therapy. Phys Med Biol. 2021 11 15; 66(22).
Sung W, Hong TS, Poznansky MC, Paganetti H, Grassberger C
Mathematical Modeling to Simulate the Effect of Adding Radiation Therapy to Immunotherapy and Application to Hepatocellular Carcinoma. Int J Radiat Oncol Biol Phys. 2022 03 15; 112(4):1055-1062.
Mathematical Modeling to Simulate the Effect of Adding Radiation Therapy to Immunotherapy and Application to Hepatocellular Carcinoma.
Nesteruk KP, Bobic M, Lalonde A, Winey BA, Lomax AJ, Paganetti H
CT-on-Rails Versus In-Room CBCT for Online Daily Adaptive Proton Therapy of Head-and-Neck Cancers. Cancers (Basel). 2021 Nov 28; 13(23).
CT-on-Rails Versus In-Room CBCT for Online Daily Adaptive Proton Therapy of Head-and-Neck Cancers.
Bertolet A, Wehrenberg-Klee E, Bobic M, Grassberger C, Perl J, Paganetti H, Schuemann J
Pre- and post-treatment image-based dosimetry in90Y-microsphere radioembolization using the TOPAS Monte Carlo toolkit. Phys Med Biol. 2021 12 29; 66(24).
Pre- and post-treatment image-based dosimetry in90Y-microsphere radioembolization using the TOPAS Monte Carlo toolkit.
Xing S, Shin J, Pursley J, Correa-Alfonso CM, Depauw N, Domal S, Withrow J, Bolch W, Grassberger C, Paganetti H
A dynamic blood flow model to compute absorbed dose to circulating blood and lymphocytes in liver external beam radiotherapy. Phys Med Biol. 2022 02 15; 67(4).
A dynamic blood flow model to compute absorbed dose to circulating blood and lymphocytes in liver external beam radiotherapy.
Manganaro L, Attili A, Bortfeld T, Paganetti H
Spatiotemporal optimisation of prostate intensity modulated proton therapy (IMPT) treatments. Phys Med Biol. 2022 02 10; 67(4).
Spatiotemporal optimisation of prostate intensity modulated proton therapy (IMPT) treatments.
Chamseddine I, Kim Y, De B, El Naqa I, Duda DG, Wolfgang J, Pursley J, Paganetti H, Wo J, Hong T, Koay EJ, Grassberger C
Predictive Modeling of Survival and Toxicity in Patients With Hepatocellular Carcinoma After Radiotherapy. JCO Clin Cancer Inform. 2022 02; 6:e2100169.
Predictive Modeling of Survival and Toxicity in Patients With Hepatocellular Carcinoma After Radiotherapy.
Correa-Alfonso CM, Withrow JD, Domal SJ, Xing S, Shin J, Grassberger C, Paganetti H, Bolch WE
A mesh-based model of liver vasculature: implications for improved radiation dosimetry to liver parenchyma for radiopharmaceuticals. EJNMMI Phys. 2022 Apr 13; 9(1):28.
A mesh-based model of liver vasculature: implications for improved radiation dosimetry to liver parenchyma for radiopharmaceuticals.
Mairani A, Mein S, Blakely E, Debus J, Durante M, Ferrari A, Fuchs H, Georg D, Grosshans DR, Guan F, Haberer T, Harrabi S, Horst F, Inaniwa T, Karger CP, Mohan R, Paganetti H, Parodi K, Sala P, Schuy C, Tessonnier T, Titt U, Weber U
Roadmap: helium ion therapy. Phys Med Biol. 2022 08 05; 67(15).
Lee H, Shin J, Verburg JM, Bobic M, Winey B, Schuemann J, Paganetti H
MOQUI: an open-source GPU-based Monte Carlo code for proton dose calculation with efficient data structure. Phys Med Biol. 2022 08 30; 67(17).
MOQUI: an open-source GPU-based Monte Carlo code for proton dose calculation with efficient data structure.
Nenoff L, Buti G, Bobic M, Lalonde A, Nesteruk KP, Winey B, Sharp GC, Sudhyadhom A, Paganetti H
Integrating Structure Propagation Uncertainties in the Optimization of Online Adaptive Proton Therapy Plans. Cancers (Basel). 2022 Aug 14; 14(16).
Integrating Structure Propagation Uncertainties in the Optimization of Online Adaptive Proton Therapy Plans.
Bertolet A, Ramos-Méndez J, McNamara A, Yoo D, Ingram S, Henthorn N, Warmenhoven JW, Faddegon B, Merchant M, McMahon SJ, Paganetti H, Schuemann J
Impact of DNA Geometry and Scoring on Monte Carlo Track-Structure Simulations of Initial Radiation-Induced Damage. Radiat Res. 2022 09 01; 198(3):207-220.
Impact of DNA Geometry and Scoring on Monte Carlo Track-Structure Simulations of Initial Radiation-Induced Damage.
Pompos A, Foote RL, Koong AC, Le QT, Mohan R, Paganetti H, Choy H
National Effort to Re-Establish Heavy Ion Cancer Therapy in the United States. Front Oncol. 2022; 12:880712.
National Effort to Re-Establish Heavy Ion Cancer Therapy in the United States.
Nesteruk KP, Bobic M, Sharp GC, Lalonde A, Winey BA, Nenoff L, Lomax AJ, Paganetti H
Low-Dose Computed Tomography Scanning Protocols for Online Adaptive Proton Therapy of Head-and-Neck Cancers. Cancers (Basel). 2022 Oct 21; 14(20).
Low-Dose Computed Tomography Scanning Protocols for Online Adaptive Proton Therapy of Head-and-Neck Cancers.
Chamseddine I, Kim Y, De B, Naqa IE, Duda DG, Wolfgang JA, Pursley J, Wo JY, Hong TS, Paganetti H, Koay EJ, Grassberger C
Predictive Model of Liver Toxicity to Aid the Personalized Selection of Proton Versus Photon Therapy in Hepatocellular Carcinoma. Int J Radiat Oncol Biol Phys. 2023 08 01; 116(5):1234-1243.
Predictive Model of Liver Toxicity to Aid the Personalized Selection of Proton Versus Photon Therapy in Hepatocellular Carcinoma.
McCullum L, Shin J, Xing S, Beekman C, Schuemann J, Hong T, Duda D, Mohan R, Lin SH, Correa-Alfonso CM, Domal S, Withrow J, Bolch W, Paganetti H, Grassberger C
Predicting Severity of Radiation Induced Lymphopenia in Individual Proton Therapy Patients for Varying Dose Rate and Fractionation Using Dynamic 4-Dimensional Blood Flow Simulations. Int J Radiat Oncol Biol Phys. 2023 08 01; 116(5):1226-1233.
Predicting Severity of Radiation Induced Lymphopenia in Individual Proton Therapy Patients for Varying Dose Rate and Fractionation Using Dynamic 4-Dimensional Blood Flow Simulations.
Kim Y, Chamseddine I, Cho Y, Kim JS, Mohan R, Shusharina N, Paganetti H, Lin S, Yoon HI, Cho S, Grassberger C
Neural network based ensemble model to predict radiation induced lymphopenia after concurrent chemo-radiotherapy for non-small cell lung cancer from two institutions. Neoplasia. 2023 05; 39:100889.
Neural network based ensemble model to predict radiation induced lymphopenia after concurrent chemo-radiotherapy for non-small cell lung cancer from two institutions.
Lee H, Cheon BW, Feld JW, Grogg K, Perl J, Ramos-Méndez JA, Faddegon B, Min CH, Paganetti H, Schuemann J
TOPAS-imaging: extensions to the TOPAS simulation toolkit for medical imaging systems. Phys Med Biol. 2023 04 03; 68(8).
TOPAS-imaging: extensions to the TOPAS simulation toolkit for medical imaging systems.
Lalonde A, Bobic M, Sharp GC, Chamseddine I, Winey B, Paganetti H
Evaluating the effect of setup uncertainty reduction and adaptation to geometric changes on normal tissue complication probability using online adaptive head and neck intensity modulated proton therapy. Phys Med Biol. 2023 05 30; 68(11).
Evaluating the effect of setup uncertainty reduction and adaptation to geometric changes on normal tissue complication probability using online adaptive head and neck intensity modulated proton therapy.
Bobic M, Lalonde A, Nesteruk KP, Lee H, Nenoff L, Gorissen BL, Bertolet A, Busse PM, Chan AW, Winey BA, Sharp GC, Verburg JM, Lomax AJ, Paganetti H
Clinical and translational radiation oncology
Large anatomical changes in head-and-neck cancers - A dosimetric comparison of online and offline adaptive proton therapy. Clin Transl Radiat Oncol. 2023 May; 40:100625.
Large anatomical changes in head-and-neck cancers - A dosimetric comparison of online and offline adaptive proton therapy.
Bertolet A, Chamseddine I, Paganetti H, Schuemann J
The complexity of DNA damage by radiation follows a Gamma distribution: insights from the Microdosimetric Gamma Model. Front Oncol. 2023; 13:1196502.
The complexity of DNA damage by radiation follows a Gamma distribution: insights from the Microdosimetric Gamma Model.
Correa-Alfonso CM, Withrow JD, Domal SJ, President BN, Dawson RJ, McCullum L, Beekman C, Grassberger C, Paganetti H, Bolch WE
Intra-brain vascular models within the ICRP mesh-type adult reference phantoms for applications to internal dosimetry. Phys Med Biol. 2023 05 02; 68(10).
Intra-brain vascular models within the ICRP mesh-type adult reference phantoms for applications to internal dosimetry.
A review on lymphocyte radiosensitivity and its impact on radiotherapy. Front Oncol. 2023; 13:1201500.
A review on lymphocyte radiosensitivity and its impact on radiotherapy.
Nenoff L, Sudhyadhom A, Lau J, Sharp GC, Paganetti H, Pursley J
Comparing Predicted Toxicities between Hypofractionated Proton and Photon Radiotherapy of Liver Cancer Patients with Different Adaptive Schemes. Cancers (Basel). 2023 Sep 15; 15(18).
Comparing Predicted Toxicities between Hypofractionated Proton and Photon Radiotherapy of Liver Cancer Patients with Different Adaptive Schemes.
Beekman C, Withrow JD, Correa Alfonso CM, Pathak SP, Dawson RJ, Carrasco-Rojas N, Sforza AR, Colon CG, Bolch WE, Grassberger C, Paganetti H
A stochastic model of blood flow to calculate blood dose during radiotherapy. Phys Med Biol. 2023 11 08; 68(22).
A stochastic model of blood flow to calculate blood dose during radiotherapy.
Warmenhoven JW, Henthorn NT, McNamara AL, Ingram SP, Merchant MJ, Kirkby KJ, Schuemann J, Paganetti H, Prise KM, McMahon SJ
Effects of Differing Underlying Assumptions in In Silico Models on Predictions of DNA Damage and Repair. Radiat Res. 2023 12 01; 200(6):509-522.
Effects of Differing Underlying Assumptions in In Silico Models on Predictions of DNA Damage and Repair.
Berrington de González A, Gibson TM, Lee C, Albert PS, Griffin KT, Kitahara CM, Liu D, Mille MM, Shin J, Bajaj BVM, Flood TE, Gallotto SL, Paganetti H, Ahmed SK, Eaton BR, Indelicato DJ, Milgrom SA, Palmer JD, Baliga S, Poppe MM, Tsang DS, Wong K, Yock TI
The Pediatric Proton and Photon Therapy Comparison Cohort: Study Design for a Multicenter Retrospective Cohort to Investigate Subsequent Cancers After Pediatric Radiation Therapy. Adv Radiat Oncol. 2023 Nov-Dec; 8(6):101273.
The Pediatric Proton and Photon Therapy Comparison Cohort: Study Design for a Multicenter Retrospective Cohort to Investigate Subsequent Cancers After Pediatric Radiation Therapy.
Huesa-Berral C, Withrow JD, Dawson RJ, Beekman C, Bolch WE, Paganetti H, Wehrenberg-Klee E, Bertolet A
European journal of nuclear medicine and molecular imaging
MIDOS: a novel stochastic model towards a treatment planning system for microsphere dosimetry in liver tumors. Eur J Nucl Med Mol Imaging. 2024 May; 51(6):1506-1515.
MIDOS: a novel stochastic model towards a treatment planning system for microsphere dosimetry in liver tumors.
Moteabbed M, Bobic M, Paganetti H, Efstathiou JA
The Role of Proton Therapy for Prostate Cancer in the Setting of Hip Prosthesis. Cancers (Basel). 2024 Jan 11; 16(2).
The Role of Proton Therapy for Prostate Cancer in the Setting of Hip Prosthesis.
Pursley J, Remillard K, Depauw N, Lee G, Grassberger C, Paganetti H, Efstathiou JA, Kamran SC
Radiation Therapy for Stage IIA/B Seminoma: Modeling Secondary Cancer Risk for Protons and VMAT versus 3D Photons. Cancers (Basel). 2024 Feb 15; 16(4).
Radiation Therapy for Stage IIA/B Seminoma: Modeling Secondary Cancer Risk for Protons and VMAT versus 3D Photons.
Bobic M, Christensen JB, Lee H, Choulilitsa E, Czerska K, Togno M, Safai S, Yukihara EG, Winey BA, Lomax AJ, Paganetti H, Albertini F, Nesteruk KP
Optically stimulated luminescence dosimeters for simultaneous measurement of point dose and dose-weighted LET in an adaptive proton therapy workflow. Front Oncol. 2023; 13:1333039.
Optically stimulated luminescence dosimeters for simultaneous measurement of point dose and dose-weighted LET in an adaptive proton therapy workflow.
Ramos-Mendez J, Ortiz CR, Schuemann J, Paganetti H, Faddegon B
TOPAS simulation of photoneutrons in radiotherapy: accuracy and speed with variance reduction. Phys Med Biol. 2024 May 14; 69(11).
TOPAS simulation of photoneutrons in radiotherapy: accuracy and speed with variance reduction.
Nowicka Z, Kuna K, Laszczych M, Lazar-Poniatowska M, Sobocki BK, Stawiski K, Dabrowski M, Bruski K, Zieba A, Pajdzinski M, Staniewska E, Miszczyk M, Paganetti H, Fendler W, Tomasik B
Physics and imaging in radiation oncology
Dose-volume metric-based prediction of radiotherapy-induced lymphocyte loss in patients with non-small-cell lung cancer treated with modern radiotherapy techniques. Phys Imaging Radiat Oncol. 2024 Apr; 30:100593.
Dose-volume metric-based prediction of radiotherapy-induced lymphocyte loss in patients with non-small-cell lung cancer treated with modern radiotherapy techniques.
Karageorgos GM, Zhang J, Peters N, Xia W, Niu C, Paganetti H, Wang G, De Man B
A Denoising Diffusion Probabilistic Model for Metal Artifact Reduction in CT. IEEE Trans Med Imaging. 2024 10; 43(10):3521-3532.
A Denoising Diffusion Probabilistic Model for Metal Artifact Reduction in CT.
Bobic M, Choulilitsa E, Lee H, Czerska K, Christensen JB, Mayor A, Safai S, Winey BA, Weber DC, Lomax AJ, Paganetti H, Nesteruk KP, Albertini F
Multi-institutional experimental validation of online adaptive proton therapy workflows. Phys Med Biol. 2024 Aug 06; 69(16).
Multi-institutional experimental validation of online adaptive proton therapy workflows.
Meyer I, Peters N, Tamborino G, Lee H, Bertolet A, Faddegon B, Mille MM, Lee C, Schuemann J, Paganetti H
A framework for in-field and out-of-field patient specific secondary cancer risk estimates from treatment plans using the TOPAS Monte Carlo system. Phys Med Biol. 2024 Aug 06; 69(16).
A framework for in-field and out-of-field patient specific secondary cancer risk estimates from treatment plans using the TOPAS Monte Carlo system.
Mein S, Wuyckens S, Li X, Both S, Carabe A, Vera MC, Engwall E, Francesco F, Graeff C, Gu W, Hong L, Inaniwa T, Janssens G, de Jong B, Li T, Liang X, Liu G, Lomax A, Mackie T, Mairani A, Mazal A, Nesteruk KP, Paganetti H, Pérez Moreno JM, Schreuder N, Soukup M, Tanaka S, Tessonnier T, Volz L, Zhao L, Ding X
Particle arc therapy: Status and potential. Radiother Oncol. 2024 10; 199:110434.
Particle arc therapy: Status and potential.
Chamseddine I, Shah K, Lee H, Ehret F, Schuemann J, Bertolet A, Shih HA, Paganetti H
Clinical cancer research : an official journal of the American Association for Cancer Research
Decoding Patient Heterogeneity Influencing Radiation-Induced Brain Necrosis. Clin Cancer Res. 2024 Oct 01; 30(19):4424-4433.
Decoding Patient Heterogeneity Influencing Radiation-Induced Brain Necrosis.
Paganetti H, Simone CB, Bosch WR, Haas-Kogan D, Kirsch DG, Li H, Liang X, Liu W, Mahajan A, Story MD, Taylor PA, Willers H, Xiao Y, Buchsbaum JC
NRG Oncology White Paper on the Relative Biological Effectiveness in Proton Therapy. Int J Radiat Oncol Biol Phys. 2025 Jan 01; 121(1):202-217.
NRG Oncology White Paper on the Relative Biological Effectiveness in Proton Therapy.
Zeng C, Giantsoudi D, Grassberger C, Goldberg S, Niemierko A, Paganetti H, Efstathiou JA, Trofimov A
Maximizing the biological effect of proton dose delivered with scanned beams via inhomogeneous daily dose distributions. Med Phys. 2013 May; 40(5):051708.
Maximizing the biological effect of proton dose delivered with scanned beams via inhomogeneous daily dose distributions.
Dowdell S, Grassberger C, Sharp GC, Paganetti H
Interplay effects in proton scanning for lung: a 4D Monte Carlo study assessing the impact of tumor and beam delivery parameters. Phys Med Biol. 2013 Jun 21; 58(12):4137-56.
Interplay effects in proton scanning for lung: a 4D Monte Carlo study assessing the impact of tumor and beam delivery parameters.
Bueno M, Paganetti H, Duch MA, Schuemann J
An algorithm to assess the need for clinical Monte Carlo dose calculation for small proton therapy fields based on quantification of tissue heterogeneity. Med Phys. 2013 Aug; 40(8):081704.
An algorithm to assess the need for clinical Monte Carlo dose calculation for small proton therapy fields based on quantification of tissue heterogeneity.
Ramos-Méndez J, Perl J, Faddegon B, Schümann J, Paganetti H
Geometrical splitting technique to improve the computational efficiency in Monte Carlo calculations for proton therapy. Med Phys. 2013 Apr; 40(4):041718.
Geometrical splitting technique to improve the computational efficiency in Monte Carlo calculations for proton therapy.
Giantsoudi D, Grassberger C, Craft D, Niemierko A, Trofimov A, Paganetti H
Linear energy transfer-guided optimization in intensity modulated proton therapy: feasibility study and clinical potential. Int J Radiat Oncol Biol Phys. 2013 Sep 01; 87(1):216-22.
Linear energy transfer-guided optimization in intensity modulated proton therapy: feasibility study and clinical potential.
Grassberger C, Dowdell S, Lomax A, Sharp G, Shackleford J, Choi N, Willers H, Paganetti H
Motion interplay as a function of patient parameters and spot size in spot scanning proton therapy for lung cancer. Int J Radiat Oncol Biol Phys. 2013 Jun 01; 86(2):380-6.
Motion interplay as a function of patient parameters and spot size in spot scanning proton therapy for lung cancer.
Cho J, Ibbott G, Gillin M, Gonzalez-Lepera C, Min CH, Zhu X, El Fakhri G, Paganetti H, Mawlawi O
Determination of elemental tissue composition following proton treatment using positron emission tomography. Phys Med Biol. 2013 Jun 07; 58(11):3815-35.
Determination of elemental tissue composition following proton treatment using positron emission tomography.
Kunz LV, Bosque JJ, Nikmaneshi M, Chamseddine I, Munn LL, Schuemann J, Paganetti H, Bertolet A
AMBER: A Modular Model for Tumor Growth, Vasculature and Radiation Response. Bull Math Biol. 2024 Oct 26; 86(12):139.
AMBER: A Modular Model for Tumor Growth, Vasculature and Radiation Response.
Xing S, Correa-Alfonso CM, Shin J, Pursley J, Depauw N, Domal S, Withrow J, Bolch W, Grassberger C, Paganetti H
Evaluating the Impact of Liver Vasculature Model Complexity for Estimating Dose to Circulating Blood During Radiation Therapy. Int J Radiat Oncol Biol Phys. 2025 Apr 01; 121(5):1339-1348.
Evaluating the Impact of Liver Vasculature Model Complexity for Estimating Dose to Circulating Blood During Radiation Therapy.
Shin WG, D-Kondo JN, Ramos-Méndez J, LaVerne JA, Rothwell B, Bertolet A, McNamara A, Faddegon B, Paganetti H, Schuemann J
Investigation of hydrogen peroxide yields and oxygen consumption in high dose rate irradiation: a TOPAS-nBio Monte Carlo study. Phys Med Biol. 2024 Dec 24; 70(1).
Investigation of hydrogen peroxide yields and oxygen consumption in high dose rate irradiation: a TOPAS-nBio Monte Carlo study.
Xiao Y, Benedict S, Cui Y, Glide-Hurst C, Graves S, Jia X, Kry SF, Li H, Lin L, Matuszak M, Newpower M, Paganetti H, Qi XS, Roncali E, Rong Y, Sgouros G, Simone CB, Sunderland JJ, Taylor PA, Tchelebi L, Weldon M, Zou JW, Wuthrick EJ, Machtay M, Le QT, Buchsbaum JC
Embracing the Future of Clinical Trials in Radiation Therapy: An NRG Oncology CIRO Technology Retreat Whitepaper on Pioneering Technologies and AI-Driven Solutions. Int J Radiat Oncol Biol Phys. 2025 Jun 01; 122(2):443-457.
Embracing the Future of Clinical Trials in Radiation Therapy: An NRG Oncology CIRO Technology Retreat Whitepaper on Pioneering Technologies and AI-Driven Solutions.
Choulilitsa E, Bobic M, Winey B, Paganetti H, Lomax AJ, Albertini F
Multi-institution investigations of online daily adaptive proton strategies for head and neck cancer patients. Phys Med Biol. 2025 Mar 11; 70(6).
Multi-institution investigations of online daily adaptive proton strategies for head and neck cancer patients.
Cho J, Ibbott G, Gillin M, Gonzalez-Lepera C, Titt U, Paganetti H, Kerr M, Mawlawi O
Feasibility of proton-activated implantable markers for proton range verification using PET. Phys Med Biol. 2013 Nov 07; 58(21):7497-512.
Feasibility of proton-activated implantable markers for proton range verification using PET.
Advancing (proton) radiation therapy. Int J Radiat Oncol Biol Phys. 2013 Dec 01; 87(5):871-3.
Testa M, Verburg JM, Rose M, Min CH, Tang S, Bentefour EH, Paganetti H, Lu HM
Proton radiography and proton computed tomography based on time-resolved dose measurements. Phys Med Biol. 2013 Nov 21; 58(22):8215-33.
Proton radiography and proton computed tomography based on time-resolved dose measurements.
Shah KD, Yeap BY, Lee H, Soetan ZO, Moteabbed M, Muise S, Cowan J, Remillard K, Silvia B, Mendenhall NP, Soffen E, Mishra MV, Kamran SC, Miyamoto DT, Paganetti H, Efstathiou JA, Chamseddine I
Predictive Model of Acute Rectal Toxicity in Prostate Cancer Treated With Radiotherapy. JCO Clin Cancer Inform. 2025 Mar; 9:e2400252.
Predictive Model of Acute Rectal Toxicity in Prostate Cancer Treated With Radiotherapy.
Su T, Yu X, Hoseini-Ghahfarokhi M, Flint DB, Bright SJ, Antunes JIDS, Martinus DKJ, Manandhar M, Ben Kacem M, Marinello PC, Pereira EJG, Chiu HS, Titt U, Grosshans DR, Schuemann J, Willers H, Paganetti H, Sumazin P, Sawakuchi GO
Differentiation Stage Predicts Radiosensitivity in Mesenchymal-Like Pancreatic Cancer. Int J Radiat Oncol Biol Phys. 2025 Sep 01; 123(1):270-281.
Differentiation Stage Predicts Radiosensitivity in Mesenchymal-Like Pancreatic Cancer.
Beekman C, Carrasco-Rojas N, Withrow J, Dawson R, Bolch WE, Paganetti H
Radiation-Induced Lymphopenia: In Silico Replications of Preclinical Studies Suggest Importance of Dose to Lymphoid Organs. Int J Radiat Oncol Biol Phys. 2025 Oct 01; 123(2):550-562.
Radiation-Induced Lymphopenia: In Silico Replications of Preclinical Studies Suggest Importance of Dose to Lymphoid Organs.
Four-dimensional Monte Carlo simulations demonstrating how the extent of intensity-modulation impacts motion effects in proton therapy lung treatments. Med Phys. 2013 Dec; 40(12):121713.
Four-dimensional Monte Carlo simulations demonstrating how the extent of intensity-modulation impacts motion effects in proton therapy lung treatments.
Grosse N, Fontana AO, Hug EB, Lomax A, Coray A, Augsburger M, Paganetti H, Sartori AA, Pruschy M
Deficiency in homologous recombination renders Mammalian cells more sensitive to proton versus photon irradiation. Int J Radiat Oncol Biol Phys. 2014 Jan 01; 88(1):175-81.
Deficiency in homologous recombination renders Mammalian cells more sensitive to proton versus photon irradiation.
Dawson RJ, Huesa-Berral C, Carter LM, Beekman C, Choi C, Shin B, Bobic M, Cogno N, Withrow JD, Jokisch DW, Bertolet A, Paganetti H, Bolch WE
Dosimetrically coupled multiscale tetrahedral mesh models of human liver vasculature: implications for radiopharmaceutical dosimetry of both organ blood and parenchyma. Phys Med Biol. 2025 Jun 19; 70(12).
Dosimetrically coupled multiscale tetrahedral mesh models of human liver vasculature: implications for radiopharmaceutical dosimetry of both organ blood and parenchyma.
Grogg K, Zhu X, Min CH, Winey B, Bortfeld T, Paganetti H, Shih HA, El Fakhri G
Feasibility of Using Distal Endpoints for In-room PET Range Verification of Proton Therapy. IEEE Trans Nucl Sci. 2013 Oct; 60(5):3290-3297.
Feasibility of Using Distal Endpoints for In-room PET Range Verification of Proton Therapy.
Gerweck LE, Huang P, Lu HM, Paganetti H, Zhou Y
Lifetime increased cancer risk in mice following exposure to clinical proton beam-generated neutrons. Int J Radiat Oncol Biol Phys. 2014 May 01; 89(1):161-6.
Lifetime increased cancer risk in mice following exposure to clinical proton beam-generated neutrons.
Onecha VV, Schuemann J, Paganetti H, Bertolet A
Extending the microdosimetry gamma model (MGM) to estimate induced DNA damage and its complexity at macroscopic scale by protons and helium ions. Phys Med Biol. 2025 Oct 17; 70(20).
Extending the microdosimetry gamma model (MGM) to estimate induced DNA damage and its complexity at macroscopic scale by protons and helium ions.
Sethi RV, Giantsoudi D, Raiford M, Malhi I, Niemierko A, Rapalino O, Caruso P, Yock TI, Tarbell NJ, Paganetti H, MacDonald SM
Patterns of failure after proton therapy in medulloblastoma; linear energy transfer distributions and relative biological effectiveness associations for relapses. Int J Radiat Oncol Biol Phys. 2014 Mar 01; 88(3):655-63.
Patterns of failure after proton therapy in medulloblastoma; linear energy transfer distributions and relative biological effectiveness associations for relapses.
Testa M, Schümann J, Lu HM, Shin J, Faddegon B, Perl J, Paganetti H
Experimental validation of the TOPAS Monte Carlo system for passive scattering proton therapy. Med Phys. 2013 Dec; 40(12):121719.
Experimental validation of the TOPAS Monte Carlo system for passive scattering proton therapy.
Bobic M, Bushe DH, Lee H, Winey BA, Efstathiou JA, Paganetti H, Pursley J, Peters N, Nenoff L
Comparison of cone beam computed tomography post-processing methods for online adaptive proton therapy of prostate cancer. Phys Imaging Radiat Oncol. 2025 Oct; 36:100858.
Comparison of cone beam computed tomography post-processing methods for online adaptive proton therapy of prostate cancer.
Grassberger C, Daartz J, Dowdell S, Ruggieri T, Sharp G, Paganetti H
Quantification of proton dose calculation accuracy in the lung. Int J Radiat Oncol Biol Phys. 2014 Jun 01; 89(2):424-30.
Quantification of proton dose calculation accuracy in the lung.
Hünemohr N, Paganetti H, Greilich S, Jäkel O, Seco J
Tissue decomposition from dual energy CT data for MC based dose calculation in particle therapy. Med Phys. 2014 Jun; 41(6):061714.
Tissue decomposition from dual energy CT data for MC based dose calculation in particle therapy.
The risk of radiation-induced second cancers in the high to medium dose region: a comparison between passive and scanned proton therapy, IMRT and VMAT for pediatric patients with brain tumors. Phys Med Biol. 2014 Jun 21; 59(12):2883-99.
The risk of radiation-induced second cancers in the high to medium dose region: a comparison between passive and scanned proton therapy, IMRT and VMAT for pediatric patients with brain tumors.
Peters N, Haneda E, Zhang J, Karageorgos G, Xia W, Verburg J, Wang G, Paganetti H, De Man B
A hybrid training database and evaluation benchmark for assessing metal artifact reduction methods for X-ray CT imaging. Med Phys. 2025 Oct; 52(10):e70020.
A hybrid training database and evaluation benchmark for assessing metal artifact reduction methods for X-ray CT imaging.
Haneda E, Peters N, Zhang J, Karageorgos G, Xia W, Paganetti H, Wang G, Guo Y, Ma J, Park HS, Jeon K, Fan F, Thies M, De Man B
AAPM CT metal artifact reduction grand challenge. Med Phys. 2025 Oct; 52(10):e70050.
AAPM CT metal artifact reduction grand challenge.
Cogno N, Shah KD, Ehret F, Beekman C, Enderling H, Dawson RJ, Bolch WE, Shih HA, Paganetti H, Chamseddine I
A Mechanistic Model of Brain Necrosis Progression Based on Vascular Heterogeneity. Int J Radiat Oncol Biol Phys. 2026 Mar 01; 124(3):842-855.
A Mechanistic Model of Brain Necrosis Progression Based on Vascular Heterogeneity.
Shah KD, Chamseddine I, Yuan X, Tian S, Qiu R, Zhou J, Dhabaan A, Al-Hallaq H, Yu DS, Paganetti H, Yang X
Clinically Interpretable Survival Risk Stratification in Head and Neck Cancer Using Bayesian Networks and Markov Blankets. Int J Radiat Oncol Biol Phys. 2026 Mar 01; 124(3):856-867.
Clinically Interpretable Survival Risk Stratification in Head and Neck Cancer Using Bayesian Networks and Markov Blankets.
Erratum to Xiao Y, Benedict S, Cui Y, Glide-Hurst C, Graves S, Jia X, KryF S, Li H, Lin L, Matuszak M, Newpower M, Paganetti H, Qi XS, Roncali E, Rong Y, Sgouros G, Simone 2nd CB, Sunderland JJ, Taylor PA, Tchelebi L, Weldon M, Zou JW, Wuthrick EJ, Machtay M, Le QT, Buchsbaum JC. Embracing the future of clinical trials in radiation therapy: an NRG oncology CIRO technology retreat whitepaper on pioneering technologies and AI-driven solutions. Int J of Radiat Oncol Biol Phys 2025:122;443-457. Int J Radiat Oncol Biol Phys. 2026 Feb 01; 124(2):560.
Erratum to Xiao Y, Benedict S, Cui Y, Glide-Hurst C, Graves S, Jia X, KryF S, Li H, Lin L, Matuszak M, Newpower M, Paganetti H, Qi XS, Roncali E, Rong Y, Sgouros G, Simone 2nd CB, Sunderland JJ, Taylor PA, Tchelebi L, Weldon M, Zou JW, Wuthrick EJ, Machtay M, Le QT, Buchsbaum JC. Embracing the future of clinical trials in radiation therapy: an NRG oncology CIRO technology retreat whitepaper on pioneering technologies and AI-driven solutions. Int J of Radiat Oncol Biol Phys 2025:122;443-457.
Griffin KT, Schuemann J, McNamara AL, Morató S, Joseph K, Esposito CE, Shin J, Mille MM, Jung JW, Lee C, Kitahara CM, Gibson TM, Berrington de González A, Yock TI, Paganetti H, Lee C
Individualized Dose-volume Reconstruction Workflow for the Normal Tissues of Pediatric Patients Treated with Passive Scattering Proton Therapy. Radiat Res. 2026 Feb 19; 205(4):323-335.
Individualized Dose-volume Reconstruction Workflow for the Normal Tissues of Pediatric Patients Treated with Passive Scattering Proton Therapy.
Shah KD, Paganetti H, Yepes P, Hong TS, Wo JY, Roberts JH, Koay EJ, Guthier CV, Chamseddine I
Linear Federated Learning for Outcome Prediction With Application to Hepatocellular Carcinoma Radiotherapy. JCO Clin Cancer Inform. 2025 Jul; 9:e2500074.
Linear Federated Learning for Outcome Prediction With Application to Hepatocellular Carcinoma Radiotherapy.
Okonogi N, Otani YS, Otani K, Pajevic PD, Xie Y, Depauw N, Paganetti H, Schuemann J, Miyamoto DT, Held KD, McNamara AL
Bystander Effects in Osteoblasts and Osteoclasts: Comparison Between X- and Proton-Irradiation. Int J Part Ther. 2025 Dec; 18:101203.
Bystander Effects in Osteoblasts and Osteoclasts: Comparison Between X- and Proton-Irradiation.
Lühr A, Mohan R, Mahajan A, Shih HA, Paganetti H
Relative Biological Effectiveness-Clinical Practice at US Proton Therapy Centers. Int J Part Ther. 2025 Dec; 18:101212.
Relative Biological Effectiveness-Clinical Practice at US Proton Therapy Centers.
Testa M, Min CH, Verburg JM, Schümann J, Lu HM, Paganetti H
Range verification of passively scattered proton beams based on prompt gamma time patterns. Phys Med Biol. 2014 Aug 07; 59(15):4181-95.
Range verification of passively scattered proton beams based on prompt gamma time patterns.
Schuemann J, Dowdell S, Grassberger C, Min CH, Paganetti H
Site-specific range uncertainties caused by dose calculation algorithms for proton therapy. Phys Med Biol. 2014 Aug 07; 59(15):4007-31.
Site-specific range uncertainties caused by dose calculation algorithms for proton therapy.
Monte Carlo simulations will change the way we treat patients with proton beams today. Br J Radiol. 2014 Aug; 87(1040):20140293.
Monte Carlo simulations will change the way we treat patients with proton beams today.
Phillips J, Gueorguiev G, Shackleford JA, Grassberger C, Dowdell S, Paganetti H, Sharp GC
Computing proton dose to irregularly moving targets. Phys Med Biol. 2014 Aug 07; 59(15):4261-73.
Computing proton dose to irregularly moving targets.
The influence of patient positioning uncertainties in proton radiotherapy on proton range and dose distributions. Med Phys. 2014 Sep; 41(9):091711.
The influence of patient positioning uncertainties in proton radiotherapy on proton range and dose distributions.
Min CH, Zhu X, Grogg K, El Fakhri G, Winey B, Paganetti H
A Recommendation on How to Analyze In-Room PET for In Vivo Proton Range Verification Using a Distal PET Surface Method. Technol Cancer Res Treat. 2015 Jun; 14(3):320-5.
A Recommendation on How to Analyze In-Room PET for In Vivo Proton Range Verification Using a Distal PET Surface Method.
Frey K, Unholtz D, Bauer J, Debus J, Min CH, Bortfeld T, Paganetti H, Parodi K
Automation and uncertainty analysis of a method for in-vivo range verification in particle therapy. Phys Med Biol. 2014 Oct 07; 59(19):5903-19.
Automation and uncertainty analysis of a method for in-vivo range verification in particle therapy.
Dosimetric feasibility of real-time MRI-guided proton therapy. Med Phys. 2014 Nov; 41(11):111713.
Dosimetric feasibility of real-time MRI-guided proton therapy.
Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer. Phys Med Biol. 2014 Nov 21; 59(22):R419-72.
Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer.
Min CH, Paganetti H, Winey BA, Adams J, MacDonald SM, Tarbell NJ, Yock TI
Evaluation of permanent alopecia in pediatric medulloblastoma patients treated with proton radiation. Radiat Oncol. 2014 Nov 18; 9:220.
Evaluation of permanent alopecia in pediatric medulloblastoma patients treated with proton radiation.
Characterizing a proton beam scanning system for Monte Carlo dose calculation in patients. Phys Med Biol. 2015 Jan 21; 60(2):633-45.
Characterizing a proton beam scanning system for Monte Carlo dose calculation in patients.
Assessment of uncertainties in radiation-induced cancer risk predictions at clinically relevant doses. Med Phys. 2015 Jan; 42(1):81-9.
Assessment of uncertainties in radiation-induced cancer risk predictions at clinically relevant doses.
Grogg K, Alpert NM, Zhu X, Min CH, Testa M, Winey B, Normandin MD, Shih HA, Paganetti H, Bortfeld T, El Fakhri G
Mapping (15)O production rate for proton therapy verification. Int J Radiat Oncol Biol Phys. 2015 Jun 01; 92(2):453-9.
Mapping (15)O production rate for proton therapy verification.
Liu Q, Ghosh P, Magpayo N, Testa M, Tang S, Gheorghiu L, Biggs P, Paganetti H, Efstathiou JA, Lu HM, Held KD, Willers H
Lung cancer cell line screen links fanconi anemia/BRCA pathway defects to increased relative biological effectiveness of proton radiation. Int J Radiat Oncol Biol Phys. 2015 Apr 01; 91(5):1081-9.
Lung cancer cell line screen links fanconi anemia/BRCA pathway defects to increased relative biological effectiveness of proton radiation.
Lin Y, McMahon SJ, Scarpelli M, Paganetti H, Schuemann J
Comparing gold nano-particle enhanced radiotherapy with protons, megavoltage photons and kilovoltage photons: a Monte Carlo simulation. Phys Med Biol. 2014 Dec 21; 59(24):7675-89.
Comparing gold nano-particle enhanced radiotherapy with protons, megavoltage photons and kilovoltage photons: a Monte Carlo simulation.
Giantsoudi D, Schuemann J, Jia X, Dowdell S, Jiang S, Paganetti H
Validation of a GPU-based Monte Carlo code (gPMC) for proton radiation therapy: clinical cases study. Phys Med Biol. 2015 Mar 21; 60(6):2257-69.
Validation of a GPU-based Monte Carlo code (gPMC) for proton radiation therapy: clinical cases study.
Relating proton treatments to photon treatments via the relative biological effectiveness-should we revise current clinical practice? Int J Radiat Oncol Biol Phys. 2015 Apr 01; 91(5):892-4.
Relating proton treatments to photon treatments via the relative biological effectiveness-should we revise current clinical practice?
Grassberger C, Dowdell S, Sharp G, Paganetti H
Motion mitigation for lung cancer patients treated with active scanning proton therapy. Med Phys. 2015 May; 42(5):2462-9.
Motion mitigation for lung cancer patients treated with active scanning proton therapy.
Wouters BG, Skarsgard LD, Gerweck LE, Carabe-Fernandez A, Wong M, Durand RE, Nielson D, Bussiere MR, Wagner M, Biggs P, Paganetti H, Suit HD
Radiobiological intercomparison of the 160 MeV and 230 MeV proton therapy beams at the Harvard Cyclotron Laboratory and at Massachusetts General Hospital. Radiat Res. 2015 Feb; 183(2):174-87.
Radiobiological intercomparison of the 160 MeV and 230 MeV proton therapy beams at the Harvard Cyclotron Laboratory and at Massachusetts General Hospital.
Lin Y, McMahon SJ, Paganetti H, Schuemann J
Biological modeling of gold nanoparticle enhanced radiotherapy for proton therapy. Phys Med Biol. 2015 May 21; 60(10):4149-68.
Biological modeling of gold nanoparticle enhanced radiotherapy for proton therapy.
Yonekura Y, Tsujii H, Hopewell JW, López PO, Cosset JM, Paganetti H, Montelius A, Schardt D, Jones B, Nakamura T
ICRP Publication 127: Radiological Protection in Ion Beam Radiotherapy. Ann ICRP. 2014 12; 43(4):5-113.
ICRP Publication 127: Radiological Protection in Ion Beam Radiotherapy.
Monitoring proton therapy with PET. Br J Radiol. 2015 Jul; 88(1051):20150173.
Ramos-Méndez J, Perl J, Schümann J, Shin J, Paganetti H, Faddegon B
A framework for implementation of organ effect models in TOPAS with benchmarks extended to proton therapy. Phys Med Biol. 2015 Jul 07; 60(13):5037-52.
A framework for implementation of organ effect models in TOPAS with benchmarks extended to proton therapy.
Polster L, Schuemann J, Rinaldi I, Burigo L, McNamara AL, Stewart RD, Attili A, Carlson DJ, Sato T, Ramos Méndez J, Faddegon B, Perl J, Paganetti H
Extension of TOPAS for the simulation of proton radiation effects considering molecular and cellular endpoints. Phys Med Biol. 2015 Jul 07; 60(13):5053-70.
Extension of TOPAS for the simulation of proton radiation effects considering molecular and cellular endpoints.
Phillips J, Gueorguiev G, Grassberger C, Paganetti H, Sharp G
SU-E-T-639: Proton Dose Calculation for Irregular Motion Using a Sliding Interface. Med Phys. 2015 Jun; 42(6):3483.
SU-E-T-639: Proton Dose Calculation for Irregular Motion Using a Sliding Interface.
TH-AB-304-10: Modeling Organ Specific Mechanistic Interactions Between Radiation and Chemotherapy. Med Phys. 2015 Jun; 42(6):3703.
TH-AB-304-10: Modeling Organ Specific Mechanistic Interactions Between Radiation and Chemotherapy.
Underwood T, Giantsoudi D, Moteabbed M, Zietman A, Efstathiou J, Paganetti H, Lu HM
TU-EF-304-05: Anterior Proton Beams for Prostate Treatments Lead to Substantial Elevations in Modeled RBE-Weighted Rectal Dose. Med Phys. 2015 Jun; 42(6):3615.
TU-EF-304-05: Anterior Proton Beams for Prostate Treatments Lead to Substantial Elevations in Modeled RBE-Weighted Rectal Dose.
TU-F-CAMPUS-T-02: Risk Assessment of Scattered Neutrons for a Fetus From Proton Therapy of a Brain Tumor During Pregnancy. Med Phys. 2015 Jun; 42(6):3636.
TU-F-CAMPUS-T-02: Risk Assessment of Scattered Neutrons for a Fetus From Proton Therapy of a Brain Tumor During Pregnancy.
MO-FG-BRA-06: Material Optimisation for Nanoparticle-Sensitized Radiotherapy. Med Phys. 2015 Jun; 42(6):3565.
MO-FG-BRA-06: Material Optimisation for Nanoparticle-Sensitized Radiotherapy.
Gorissen BL, Giantsoudi D, Unkelbach J, Paganetti H
TU-EF-304-08: LET-Based Inverse Planning for IMPT. Med Phys. 2015 Jun; 42(6):3616.
TU-EF-304-08: LET-Based Inverse Planning for IMPT.
SU-E-T-22: A Deterministic Solver of the Boltzmann-Fokker-Planck Equation for Dose Calculation. Med Phys. 2015 Jun; 42(6):3335.
SU-E-T-22: A Deterministic Solver of the Boltzmann-Fokker-Planck Equation for Dose Calculation.
Toltz A, Hoesl M, Schuemann J, Seuntjens J, Lu H, Paganetti H
SU-E-T-524: In-Vivo Diode Dosimetry Proton Therapy Range Verification Validation Study for Pediatric CSI. Med Phys. 2015 Jun; 42(6):3455.
SU-E-T-524: In-Vivo Diode Dosimetry Proton Therapy Range Verification Validation Study for Pediatric CSI.
Qin N, Giantsoudi D, Tian Z, Schuemann J, Pompos A, Paganetti H, Jiang S, Jia X
SU-E-T-673: Recent Developments and Comprehensive Validations of a GPU-Based Proton Monte Carlo Simulation Package, GPMC. Med Phys. 2015 Jun; 42(6):3491.
SU-E-T-673: Recent Developments and Comprehensive Validations of a GPU-Based Proton Monte Carlo Simulation Package, GPMC.
Geng C, Schuemann J, Moteabbed M, Paganetti H
SU-E-T-567: Neutron Dose Equivalent Evaluation for Pencil Beam Scanning Proton Therapy with Apertures. Med Phys. 2015 Jun; 42(6):3466.
SU-E-T-567: Neutron Dose Equivalent Evaluation for Pencil Beam Scanning Proton Therapy with Apertures.
Schuemann J, Giantsoudi D, Grassberger C, Paganetti H
SU-E-T-135: Assessing the Clinical Impact of Approximations in Analytical Dose Calculations for Proton Therapy. Med Phys. 2015 Jun; 42(6):3362.
SU-E-T-135: Assessing the Clinical Impact of Approximations in Analytical Dose Calculations for Proton Therapy.
Giantsoudi D, Jee K, Rose B, MacDonald S, Paganetti H
TU-EF-304-12: Proton Radiation Therapy for Left-Sided Breast Cancer: LET and RBE Considerations for Cardiac Toxicity. Med Phys. 2015 Jun; 42(6):3617.
TU-EF-304-12: Proton Radiation Therapy for Left-Sided Breast Cancer: LET and RBE Considerations for Cardiac Toxicity.
Lin Y, Held K, McMahon S, Paganetti H, Schuemann J
SU-E-T-518: Investigation of Gold Nanoparticle Radiosensitization for Carbon Ion Therapy. Med Phys. 2015 Jun; 42(6):3454.
SU-E-T-518: Investigation of Gold Nanoparticle Radiosensitization for Carbon Ion Therapy.
SU-E-T-769: T-Test Based Prior Error Estimate and Stopping Criterion for Monte Carlo Dose Calculation in Proton Therapy. Med Phys. 2015 Jun; 42(6):3514.
SU-E-T-769: T-Test Based Prior Error Estimate and Stopping Criterion for Monte Carlo Dose Calculation in Proton Therapy.
Sorriaux J, Testa M, Paganetti H, Bertrand D, de Xivry JO, Lee J, Palmans H, Vynckier S, Sterpin E
SU-F-BRD-15: Quality Correction Factors in Scanned Or Broad Proton Therapy Beams Are Indistinguishable. Med Phys. 2015 Jun; 42(6):3529.
SU-F-BRD-15: Quality Correction Factors in Scanned Or Broad Proton Therapy Beams Are Indistinguishable.
Méndez JR, Perl J, Schümann J, Shin J, Paganetti H, Faddegon B
Improved efficiency in Monte Carlo simulation for passive-scattering proton therapy. Phys Med Biol. 2015 Jul 07; 60(13):5019-35.
Improved efficiency in Monte Carlo simulation for passive-scattering proton therapy.
Moteabbed M, Depauw N, Kooy H, Yock T, Paganetti H
SU-F-BRD-12: When Does Pencil Beam Scanning Become Superior to Passive Scattered Proton Therapy for Pediatric Head and Neck Cancers? Med Phys. 2015 Jun; 42(6):3528.
SU-F-BRD-12: When Does Pencil Beam Scanning Become Superior to Passive Scattered Proton Therapy for Pediatric Head and Neck Cancers?
Seco J, Giantsoudi D, Eaton BR, Adams JA, Paganetti H, MacDonald S
SU-E-T-369: Evaluating Intensity Modulated Proton Therapy Relative to Passive Scattering Proton Therapy for Increased Vertebral Column Sparing in CSI of Pediatric Patients. Med Phys. 2015 Jun; 42(6):3418.
SU-E-T-369: Evaluating Intensity Modulated Proton Therapy Relative to Passive Scattering Proton Therapy for Increased Vertebral Column Sparing in CSI of Pediatric Patients.
Ramos-Mendez J, Perl J, Schuemann J, Shin J, Paganetti H, Faddegon B
SU-E-T-466: Implementation of An Extension Module for Dose Response Models in the TOPAS Monte Carlo Toolkit. Med Phys. 2015 Jun; 42(6):3441.
SU-E-T-466: Implementation of An Extension Module for Dose Response Models in the TOPAS Monte Carlo Toolkit.
SU-E-T-554: Monte Carlo Calculation of Source Terms and Attenuation Lengths for Neutrons Produced by 50-200 MeV Protons On Brass. Med Phys. 2015 Jun; 42(6):3463.
SU-E-T-554: Monte Carlo Calculation of Source Terms and Attenuation Lengths for Neutrons Produced by 50-200 MeV Protons On Brass.
Grassberger C, Sharp G, Fintelmann F, Paganetti H, Willers H
SU-E-J-247: Time Evolution of Radiation-Induced Lung Injury After Stereotactic Proton Therapy. Med Phys. 2015 Jun; 42(6):3323.
SU-E-J-247: Time Evolution of Radiation-Induced Lung Injury After Stereotactic Proton Therapy.
McNamara A, McMahon S, Lin Y, Paganetti H, Kuncic Z, Schuemann J
TU-F-CAMPUS-T-04: Using Gold Nanoparticles to Target Mitochondria in Radiation Therapy. Med Phys. 2015 Jun; 42(6):3644.
TU-F-CAMPUS-T-04: Using Gold Nanoparticles to Target Mitochondria in Radiation Therapy.
SU-E-T-752: Three-Dimensional Carcinogenic Maps Induced by Photons and Protons. Med Phys. 2015 Jun; 42(6):3510.
SU-E-T-752: Three-Dimensional Carcinogenic Maps Induced by Photons and Protons.
SU-F-BRD-13: A Phenomenological Relative Biological Effectiveness (RBE) Model for Proton Therapy Based On All Published in Vitro Cell Survival Data. Med Phys. 2015 Jun; 42(6):3528.
SU-F-BRD-13: A Phenomenological Relative Biological Effectiveness (RBE) Model for Proton Therapy Based On All Published in Vitro Cell Survival Data.
Schuemann J, Giantsoudi D, Grassberger C, Moteabbed M, Min CH, Paganetti H
Assessing the Clinical Impact of Approximations in Analytical Dose Calculations for Proton Therapy. Int J Radiat Oncol Biol Phys. 2015 Aug 01; 92(5):1157-1164.
Assessing the Clinical Impact of Approximations in Analytical Dose Calculations for Proton Therapy.
Lin Y, Paganetti H, McMahon SJ, Schuemann J
Gold nanoparticle induced vasculature damage in radiotherapy: Comparing protons, megavoltage photons, and kilovoltage photons. Med Phys. 2015 Oct; 42(10):5890-902.
Gold nanoparticle induced vasculature damage in radiotherapy: Comparing protons, megavoltage photons, and kilovoltage photons.
Chetty IJ, Martel MK, Jaffray DA, Benedict SH, Hahn SM, Berbeco R, Deye J, Jeraj R, Kavanagh B, Krishnan S, Lee N, Low DA, Mankoff D, Marks LB, Ollendorf D, Paganetti H, Ross B, Siochi RA, Timmerman RD, Wong JW
Technology for Innovation in Radiation Oncology. Int J Radiat Oncol Biol Phys. 2015 Nov 01; 93(3):485-92.
Technology for Innovation in Radiation Oncology.
A phenomenological relative biological effectiveness (RBE) model for proton therapy based on all published in vitro cell survival data. Phys Med Biol. 2015 Nov 07; 60(21):8399-416.
A phenomenological relative biological effectiveness (RBE) model for proton therapy based on all published in vitro cell survival data.
Optimising element choice for nanoparticle radiosensitisers. Nanoscale. 2016 Jan 07; 8(1):581-9.
Optimising element choice for nanoparticle radiosensitisers.
Journal of the American College of Radiology : JACR
Why Is Proton Beam Therapy So Controversial? J Am Coll Radiol. 2015 Dec; 12(12 Pt A):1318-9.
Why Is Proton Beam Therapy So Controversial?
Hall DC, Makarova A, Paganetti H, Gottschalk B
Validation of nuclear models in Geant4 using the dose distribution of a 177 MeV proton pencil beam. Phys Med Biol. 2016 Jan 07; 61(1):N1-N10.
Validation of nuclear models in Geant4 using the dose distribution of a 177 MeV proton pencil beam.
Geng C, Moteabbed M, Xie Y, Schuemann J, Yock T, Paganetti H
Assessing the radiation-induced second cancer risk in proton therapy for pediatric brain tumors: the impact of employing a patient-specific aperture in pencil beam scanning. Phys Med Biol. 2016 Jan 07; 61(1):12-22.
Assessing the radiation-induced second cancer risk in proton therapy for pediatric brain tumors: the impact of employing a patient-specific aperture in pencil beam scanning.
Geng C, Moteabbed M, Seco J, Gao Y, Xu XG, Ramos-Méndez J, Faddegon B, Paganetti H
Dose assessment for the fetus considering scattered and secondary radiation from photon and proton therapy when treating a brain tumor of the mother. Phys Med Biol. 2016 Jan 21; 61(2):683-95.
Dose assessment for the fetus considering scattered and secondary radiation from photon and proton therapy when treating a brain tumor of the mother.
Liu Q, Underwood TSA, Kung J, Wang M, Lu HM, Paganetti H, Held KD, Hong TS, Efstathiou JA, Willers H
Disruption of SLX4-MUS81 Function Increases the Relative Biological Effectiveness of Proton Radiation. Int J Radiat Oncol Biol Phys. 2016 May 01; 95(1):78-85.
Disruption of SLX4-MUS81 Function Increases the Relative Biological Effectiveness of Proton Radiation.
Can We Advance Proton Therapy for Prostate? Considering Alternative Beam Angles and Relative Biological Effectiveness Variations When Comparing Against Intensity Modulated Radiation Therapy. Int J Radiat Oncol Biol Phys. 2016 May 01; 95(1):454-464.
Can We Advance Proton Therapy for Prostate? Considering Alternative Beam Angles and Relative Biological Effectiveness Variations When Comparing Against Intensity Modulated Radiation Therapy.
Moteabbed M, Yock TI, Depauw N, Madden TM, Kooy HM, Paganetti H
Impact of Spot Size and Beam-Shaping Devices on the Treatment Plan Quality for Pencil Beam Scanning Proton Therapy. Int J Radiat Oncol Biol Phys. 2016 May 01; 95(1):190-198.
Impact of Spot Size and Beam-Shaping Devices on the Treatment Plan Quality for Pencil Beam Scanning Proton Therapy.
Variable Proton Relative Biological Effectiveness: How Do We Move Forward? Int J Radiat Oncol Biol Phys. 2016 May 01; 95(1):56-58.
Variable Proton Relative Biological Effectiveness: How Do We Move Forward?
Giantsoudi D, Sethi RV, Yeap BY, Eaton BR, Ebb DH, Caruso PA, Rapalino O, Chen YE, Adams JA, Yock TI, Tarbell NJ, Paganetti H, MacDonald SM
Incidence of CNS Injury for a Cohort of 111 Patients Treated With Proton Therapy for Medulloblastoma: LET and RBE Associations for Areas of Injury. Int J Radiat Oncol Biol Phys. 2016 May 01; 95(1):287-296.
Incidence of CNS Injury for a Cohort of 111 Patients Treated With Proton Therapy for Medulloblastoma: LET and RBE Associations for Areas of Injury.
Yonekura Y, Tsujii H, Hopewell JW, Ortiz López P, Cosset JM, Paganetti H, Montelius A, Schardt D, Jones B, Nakamura T
Radiological protection in ion beam radiotherapy: practical guidance for clinical use of new technology. Ann ICRP. 2016 Jun; 45(1 Suppl):138-47.
Radiological protection in ion beam radiotherapy: practical guidance for clinical use of new technology.
Photon radiotherapy has reached its limit in terms of catching up dosimetrically with proton therapy. Med Phys. 2016 Aug; 43(8):4470.
Photon radiotherapy has reached its limit in terms of catching up dosimetrically with proton therapy.
McNamara AL, Kam WW, Scales N, McMahon SJ, Bennett JW, Byrne HL, Schuemann J, Paganetti H, Banati R, Kuncic Z
Dose enhancement effects to the nucleus and mitochondria from gold nanoparticles in the cytosol. Phys Med Biol. 2016 08 21; 61(16):5993-6010.
Dose enhancement effects to the nucleus and mitochondria from gold nanoparticles in the cytosol.
Reports on progress in physics. Physical Society (Great Britain)
Nuclear physics in particle therapy: a review. Rep Prog Phys. 2016 09; 79(9):096702.
Nuclear physics in particle therapy: a review.
TOPAS: Fast and easy to use Monte Carlo system for proton therapy
Four-dimensional Monte Carlo dose calculation
Improving the Clinical Effectiveness and Understanding of the Biophysical Basis
Dowdell S, Grassberger C, Sharp G, Paganetti H
Fractionated Lung IMPT Treatments: Sensitivity to Setup Uncertainties and Motion Effects Based on Single-Field Homogeneity. Technol Cancer Res Treat. 2016 10; 15(5):689-96.
Fractionated Lung IMPT Treatments: Sensitivity to Setup Uncertainties and Motion Effects Based on Single-Field Homogeneity.
McMahon SJ, Schuemann J, Paganetti H, Prise KM
Mechanistic Modelling of DNA Repair and Cellular Survival Following Radiation-Induced DNA Damage. Sci Rep. 2016 09 14; 6:33290.
Mechanistic Modelling of DNA Repair and Cellular Survival Following Radiation-Induced DNA Damage.
Bednarz B, Chen G, Paganetti H, Han B, Ding A, Xu XG
COMPARISON OF PARTICLE-TRACKING FEATURES IN GEANT4 AND MCNPX CODES FOR APPLICATIONS IN MAPPING OF PROTON RANGE UNCERTAINTY. Nucl Technol. 2011 Jul; 175(1):2-5.
COMPARISON OF PARTICLE-TRACKING FEATURES IN GEANT4 AND MCNPX CODES FOR APPLICATIONS IN MAPPING OF PROTON RANGE UNCERTAINTY.
Qin N, Botas P, Giantsoudi D, Schuemann J, Tian Z, Jiang SB, Paganetti H, Jia X
Recent developments and comprehensive evaluations of a GPU-based Monte Carlo package for proton therapy. Phys Med Biol. 2016 10 21; 61(20):7347-7362.
Recent developments and comprehensive evaluations of a GPU-based Monte Carlo package for proton therapy.
Methodologies in the modeling of combined chemo-radiation treatments. Phys Med Biol. 2016 11 07; 61(21):R344-R367.
Methodologies in the modeling of combined chemo-radiation treatments.
Unkelbach J, Botas P, Giantsoudi D, Gorissen BL, Paganetti H
Reoptimization of Intensity Modulated Proton Therapy Plans Based on Linear Energy Transfer. Int J Radiat Oncol Biol Phys. 2016 12 01; 96(5):1097-1106.
Reoptimization of Intensity Modulated Proton Therapy Plans Based on Linear Energy Transfer.
Verburg JM, Grassberger C, Dowdell S, Schuemann J, Seco J, Paganetti H
Automated Monte Carlo Simulation of Proton Therapy Treatment Plans. Technol Cancer Res Treat. 2016 12; 15(6):NP35-NP46.
Automated Monte Carlo Simulation of Proton Therapy Treatment Plans.
Giantsoudi D, Adams J, MacDonald SM, Paganetti H
Proton Treatment Techniques for Posterior Fossa Tumors: Consequences for Linear Energy Transfer and Dose-Volume Parameters for the Brainstem and Organs at Risk. Int J Radiat Oncol Biol Phys. 2017 02 01; 97(2):401-410.
Proton Treatment Techniques for Posterior Fossa Tumors: Consequences for Linear Energy Transfer and Dose-Volume Parameters for the Brainstem and Organs at Risk.
Geng C, Daartz J, Lam-Tin-Cheung K, Bussiere M, Shih HA, Paganetti H, Schuemann J
Limitations of analytical dose calculations for small field proton radiosurgery. Phys Med Biol. 2017 01 07; 62(1):246-257.
Limitations of analytical dose calculations for small field proton radiosurgery.
McNamara A, Geng C, Turner R, Mendez JR, Perl J, Held K, Faddegon B, Paganetti H, Schuemann J
Validation of the radiobiology toolkit TOPAS-nBio in simple DNA geometries. Phys Med. 2017 Jan; 33:207-215.
Validation of the radiobiology toolkit TOPAS-nBio in simple DNA geometries.
Testa M, Doolan P, H BE, Paganetti H, Lu HM
SU-E-J-158: Experimental Investigation of Proton Radiography Based On Time-Resolved Dose Measurements. Med Phys. 2014 Jun; 41(6):192-193.
SU-E-J-158: Experimental Investigation of Proton Radiography Based On Time-Resolved Dose Measurements.
SU-E-T-292: Sensitivity of Fractionated Lung IMPT Treatments to Setup Uncertainties and Motion Effects. Med Phys. 2014 Jun; 41(6):291.
SU-E-T-292: Sensitivity of Fractionated Lung IMPT Treatments to Setup Uncertainties and Motion Effects.
Sterpin E, Sorriaux J, Schuemann J, Souris K, Lee J, Vynckier S, Jia X, Jiang S, Paganetti H
SU-E-T-180: Fano Cavity Test of Proton Transport in Monte Carlo Codes Running On GPU and Xeon Phi. Med Phys. 2014 Jun; 41(6):264.
SU-E-T-180: Fano Cavity Test of Proton Transport in Monte Carlo Codes Running On GPU and Xeon Phi.
Schuemann J, Dowdell S, Grassberger C, Paganetti H
TH-A-19A-06: Site-Specific Comparison of Analytical and Monte Carlo Based Dose Calculations. Med Phys. 2014 Jun; 41(6):534.
TH-A-19A-06: Site-Specific Comparison of Analytical and Monte Carlo Based Dose Calculations.
SU-E-T-375: Passive Scattering to Pencil-Beam-Scanning Comparison for Medulloblastoma Proton Therapy: LET Distributions and Radiobiological Implications. Med Phys. 2014 Jun; 41(6):311.
SU-E-T-375: Passive Scattering to Pencil-Beam-Scanning Comparison for Medulloblastoma Proton Therapy: LET Distributions and Radiobiological Implications.
WE-G-BRE-04: Gold Nanoparticle Induced Vasculature Damage for Proton Therapy: Monte Carlo Simulation. Med Phys. 2014 Jun; 41(6):517.
WE-G-BRE-04: Gold Nanoparticle Induced Vasculature Damage for Proton Therapy: Monte Carlo Simulation.
Underwood T, Grassberger C, Willers H, MacDonald S, Jimenez R, Paganetti H
WE-FG-202-03: Quantitative CT-Based Analysis to Assess Lung Injury Following Proton Radiotherapy. Med Phys. 2016 Jun; 43(6):3827.
WE-FG-202-03: Quantitative CT-Based Analysis to Assess Lung Injury Following Proton Radiotherapy.
Jin Y, Robinson V, Gjesteby L, Wang G, Verburg J, Giantsoudi D, Paganetti H, De Man B
MO-FG-CAMPUS-IeP2-05: Feasibility Demonstration of High-Voltage Clinical CT and Impact On X-Ray Penetration Through Metal Objects. Med Phys. 2016 Jun; 43(6):3720-3721.
MO-FG-CAMPUS-IeP2-05: Feasibility Demonstration of High-Voltage Clinical CT and Impact On X-Ray Penetration Through Metal Objects.
McNamara A, Underwood T, Wo J, Paganetti H
SU-F-T-132: Variable RBE Models Predict Possible Underestimation of Vaginal Dose for Anal Cancer Patients Treated Using Single-Field Proton Treatments. Med Phys. 2016 Jun; 43(6):3492.
SU-F-T-132: Variable RBE Models Predict Possible Underestimation of Vaginal Dose for Anal Cancer Patients Treated Using Single-Field Proton Treatments.
Geng C, Daartz J, Cheung K, Bussiere M, Shih H, Paganetti H, Schuemann J
SU-F-T-157: Physics Considerations Regarding Dosimetric Accuracy of Analytical Dose Calculations for Small Field Proton Therapy: A Monte Carlo Study. Med Phys. 2016 Jun; 43(6):3498.
SU-F-T-157: Physics Considerations Regarding Dosimetric Accuracy of Analytical Dose Calculations for Small Field Proton Therapy: A Monte Carlo Study.
Schuemann J, Giantsoudi D, Rinaldi I, Perl J, Faddegon B, Paganetti H
TH-A-19A-02: Expanding TOPAS Towards Biological Modeling. Med Phys. 2014 Jun; 41(6):533.
TH-A-19A-02: Expanding TOPAS Towards Biological Modeling.
SU-F-T-206: Proton Treatment Techniques for Posterior Fossa Tumors: Consequences for LET and Dose/Volume Parameters for the Brainstem and Organs at Risk. Med Phys. 2016 Jun; 43(6):3509.
SU-F-T-206: Proton Treatment Techniques for Posterior Fossa Tumors: Consequences for LET and Dose/Volume Parameters for the Brainstem and Organs at Risk.
Shin J, Jee K, Clasie B, Depauw N, Madden T, Sharp G, Paganetti H, Kooy H
SU-G-TeP4-04: An Automated Monte Carlo Based QA Framework for Pencil Beam Scanning Treatments. Med Phys. 2016 Jun; 43(6):3685.
SU-G-TeP4-04: An Automated Monte Carlo Based QA Framework for Pencil Beam Scanning Treatments.
Moteabbed M, Trofimov A, Testa M, Sharp G, Wang Y, Paganetti H, Zietman A, Efstathiou J, Lu H
SU-E-T-616: Comparison of Plan Dose Accuracy for Anterior Vs. Lateral Fields in Proton Therapy of Prostate Cancer. Med Phys. 2014 Jun; 41(6):369.
SU-E-T-616: Comparison of Plan Dose Accuracy for Anterior Vs. Lateral Fields in Proton Therapy of Prostate Cancer.
Sorriaux J, Paganetti H, Testa M, Giantsoudi D, Schuemann J, Bertrand D, Orban de Xivry J, Lee J, Palmans H, Vynckier S, Sterpin E
SU-E-T-464: On the Equivalence of the Quality Correction Factor for Pencil Beam Scanning Proton Therapy. Med Phys. 2014 Jun; 41(6):333.
SU-E-T-464: On the Equivalence of the Quality Correction Factor for Pencil Beam Scanning Proton Therapy.
McNamara A, Perl J, Piersimoni P, Ramos-Mendez J, Faddegon B, Held K, Paganetti H, Schuemann J
WE-H-BRA-04: Biological Geometries for the Monte Carlo Simulation Toolkit TOPASNBio. Med Phys. 2016 Jun; 43(6):3843.
WE-H-BRA-04: Biological Geometries for the Monte Carlo Simulation Toolkit TOPASNBio.
McMahon S, McNamara A, Schuemann J, Prise K, Paganetti H
WE-H-BRA-07: Mechanistic Modelling of the Relative Biological Effectiveness of Heavy Charged Particles. Med Phys. 2016 Jun; 43(6):3844.
WE-H-BRA-07: Mechanistic Modelling of the Relative Biological Effectiveness of Heavy Charged Particles.
Underwood T, McFadden C, Trenholm D, Verburg J, Paganetti H, Sawakuchi G, Schuemann J
TH-CD-201-07: Experimentally Investigating Proton Energy Deposition On the Microscopic Scale Using Fluorescence Nuclear Track Detectors. Med Phys. 2016 Jun; 43(6):3870-3871.
TH-CD-201-07: Experimentally Investigating Proton Energy Deposition On the Microscopic Scale Using Fluorescence Nuclear Track Detectors.
Hall D, Perl J, Schuemann J, Faddegon B, Paganetti H
SU-F-T-139: Meeting the Challenges of Quality Control in the TOPAS Monte Carlo Simulation Toolkit for Proton Therapy. Med Phys. 2016 Jun; 43(6):3493-3494.
SU-F-T-139: Meeting the Challenges of Quality Control in the TOPAS Monte Carlo Simulation Toolkit for Proton Therapy.
WE-FG-BRB-01: Clinical Significance of RBE Variations in Proton Therapy. Med Phys. 2016 Jun; 43(6):3822-3823.
WE-FG-BRB-01: Clinical Significance of RBE Variations in Proton Therapy.
Botas P, Grassberger C, Sharp G, Qin N, Jia X, Jiang S, Paganetti H
SU-G-TeP1-06: Fast GPU Framework for Four-Dimensional Monte Carlo in Adaptive Intensity Modulated Proton Therapy (IMPT) for Mobile Tumors. Med Phys. 2016 Jun; 43(6):3653.
SU-G-TeP1-06: Fast GPU Framework for Four-Dimensional Monte Carlo in Adaptive Intensity Modulated Proton Therapy (IMPT) for Mobile Tumors.
WE-G-BRE-02: Biological Modeling of Gold Nanoparticle Radiosensitization for Proton Therapy. Med Phys. 2014 Jun; 41(6):517.
WE-G-BRE-02: Biological Modeling of Gold Nanoparticle Radiosensitization for Proton Therapy.
SU-E-T-324: The Influence of Patient Positioning Uncertainties in Proton Radiotherapy On Proton Range and Dose Distributions. Med Phys. 2014 Jun; 41(6):298-299.
SU-E-T-324: The Influence of Patient Positioning Uncertainties in Proton Radiotherapy On Proton Range and Dose Distributions.
WE-H-BRA-03: Development of a Model to Include the Evolution of Resistant Tumor Subpopulations Into the Treatment Optimization Process for Schedules Involving Targeted Agents in Chemoradiation Therapy. Med Phys. 2016 Jun; 43(6):3843.
WE-H-BRA-03: Development of a Model to Include the Evolution of Resistant Tumor Subpopulations Into the Treatment Optimization Process for Schedules Involving Targeted Agents in Chemoradiation Therapy.
Unkelbach J, Botas P, Qin N, Jia X, Giantsoudi D, Paganetti H
TH-CD-209-06: LET-Based Adjustment of IMPT Plans Using Prioritized Optimization. Med Phys. 2016 Jun; 43(6):3887.
TH-CD-209-06: LET-Based Adjustment of IMPT Plans Using Prioritized Optimization.
Hall D, Trofimov A, Winey B, Liebsch N, Paganetti H
TH-CD-209-09: Quickly Identifying Good Candidates for Proton Therapy From Geometric Considerations. Med Phys. 2016 Jun; 43(6):3887-3888.
TH-CD-209-09: Quickly Identifying Good Candidates for Proton Therapy From Geometric Considerations.
TH-A-19A-03: Impact of Proton Dose Calculation Method On Delivered Dose to Lung Tumors: Experiments in Thorax Phantom and Planning Study in Patient Cohort. Med Phys. 2014 Jun; 41(6):533.
TH-A-19A-03: Impact of Proton Dose Calculation Method On Delivered Dose to Lung Tumors: Experiments in Thorax Phantom and Planning Study in Patient Cohort.
Giantsoudi D, Schuemann J, Dowdell S, Jia X, Jiang S, Paganetti H
TH-A-19A-11: Validation of GPU-Based Monte Carlo Code (gPMC) Versus Fully Implemented Monte Carlo Code (TOPAS) for Proton Radiation Therapy: Clinical Cases Study. Med Phys. 2014 Jun; 41(6):535.
TH-A-19A-11: Validation of GPU-Based Monte Carlo Code (gPMC) Versus Fully Implemented Monte Carlo Code (TOPAS) for Proton Radiation Therapy: Clinical Cases Study.
Paganetti H, Stewart R, Carabe-Fernandez A
TU-A-BRE-01: The Relative Biological Effectiveness of Proton Beams Relative to Photon Beams. Med Phys. 2014 Jun; 41(6):445.
TU-A-BRE-01: The Relative Biological Effectiveness of Proton Beams Relative to Photon Beams.
TH-D-BRC-03: Panel Member. Med Phys. 2016 Jun; 43(6):3892.
Dowdell S, Greilich S, Zimmerman F, Evans C, Paganetti H, Schuemann J
WE-D-BRF-01: FEATURED PRESENTATION - Investigating Particle Track Structures Using Fluorescent Nuclear Track Detectors and Monte Carlo Simulations. Med Phys. 2014 Jun; 41(6):495.
WE-D-BRF-01: FEATURED PRESENTATION - Investigating Particle Track Structures Using Fluorescent Nuclear Track Detectors and Monte Carlo Simulations.
WE-AB-207B-06: Dose and Biological Uncertainties in Sarcoma. Med Phys. 2016 Jun; 43(6):3805.
WE-AB-207B-06: Dose and Biological Uncertainties in Sarcoma.
Underwood TS, Voog JC, Moteabbed M, Tang S, Soffen E, Cahlon O, Lu HM, Zietman AL, Efstathiou JA, Paganetti H
Hydrogel rectum-prostate spacers mitigate the uncertainties in proton relative biological effectiveness associated with anterior-oblique beams. Acta Oncol. 2017 Apr; 56(4):575-581.
Hydrogel rectum-prostate spacers mitigate the uncertainties in proton relative biological effectiveness associated with anterior-oblique beams.
Yu JB, Mattes M, Thrasher A, Shu HG, De Los Santos JF, Paganetti H, Koontz BF, Abraham C, Balboni TA
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Attitudes of radiation oncologists toward palliative and supportive care in the United States: Report on National Membership Survey by the American Society for Radiation Oncology (ASTRO). J Clin Oncol. 2016 Oct 09; 34(26_suppl):105.
Attitudes of radiation oncologists toward palliative and supportive care in the United States: Report on National Membership Survey by the American Society for Radiation Oncology (ASTRO).
Nuclear interactions in proton therapy: dose and relative biological effect distributions originating from primary and secondary particles. Phys Med Biol. 2002 Mar 07; 47(5):747-64.
Nuclear interactions in proton therapy: dose and relative biological effect distributions originating from primary and secondary particles.
Jiang H, Wang B, Xu XG, Suit HD, Paganetti H
Simulation of organ-specific patient effective dose due to secondary neutrons in proton radiation treatment. Phys Med Biol. 2005 Sep 21; 50(18):4337-53.
Simulation of organ-specific patient effective dose due to secondary neutrons in proton radiation treatment.
Adaptation of GEANT4 to Monte Carlo dose calculations based on CT data. Med Phys. 2004 Oct; 31(10):2811-8.
Adaptation of GEANT4 to Monte Carlo dose calculations based on CT data.
Biomathematical Optimization of Radiation Therapy in the Era of Targeted Agents. Int J Radiat Oncol Biol Phys. 2017 01 01; 97(1):13-17.
Biomathematical Optimization of Radiation Therapy in the Era of Targeted Agents.
Wei RL, Mattes MD, Yu J, Thrasher A, Shu HK, Paganetti H, De Los Santos J, Koontz B, Abraham C, Balboni T
Attitudes of radiation oncologists toward palliative and supportive care in the United States: Report on national membership survey by the American Society for Radiation Oncology (ASTRO). Pract Radiat Oncol. 2017 Mar - Apr; 7(2):113-119.
Attitudes of radiation oncologists toward palliative and supportive care in the United States: Report on national membership survey by the American Society for Radiation Oncology (ASTRO).
Cho J, Grogg K, Min CH, Zhu X, Paganetti H, Lee HC, El Fakhri G
Feasibility study of using fall-off gradients of early and late PET scans for proton range verification. Med Phys. 2017 May; 44(5):1734-1746.
Feasibility study of using fall-off gradients of early and late PET scans for proton range verification.
Monte Carlo calculations for absolute dosimetry to determine machine outputs for proton therapy fields. Phys Med Biol. 2006 Jun 07; 51(11):2801-12.
Monte Carlo calculations for absolute dosimetry to determine machine outputs for proton therapy fields.
Effects of Hounsfield number conversion on CT based proton Monte Carlo dose calculations. Med Phys. 2007 Apr; 34(4):1439-49.
Effects of Hounsfield number conversion on CT based proton Monte Carlo dose calculations.
Hall DC, Trofimov AV, Winey BA, Liebsch NJ, Paganetti H
Predicting Patient-specific Dosimetric Benefits of Proton Therapy for Skull-base Tumors Using a Geometric Knowledge-based Method. Int J Radiat Oncol Biol Phys. 2017 04 01; 97(5):1087-1094.
Predicting Patient-specific Dosimetric Benefits of Proton Therapy for Skull-base Tumors Using a Geometric Knowledge-based Method.
Giantsoudi D, De Man B, Verburg J, Trofimov A, Jin Y, Wang G, Gjesteby L, Paganetti H
Metal artifacts in computed tomography for radiation therapy planning: dosimetric effects and impact of metal artifact reduction. Phys Med Biol. 2017 04 21; 62(8):R49-R80.
Metal artifacts in computed tomography for radiation therapy planning: dosimetric effects and impact of metal artifact reduction.
Athar BS, Bednarz B, Seco J, Hancox C, Paganetti H
Comparison of out-of-field photon doses in 6 MV IMRT and neutron doses in proton therapy for adult and pediatric patients. Phys Med Biol. 2010 May 21; 55(10):2879-91.
Comparison of out-of-field photon doses in 6 MV IMRT and neutron doses in proton therapy for adult and pediatric patients.
Test of GEANT3 and GEANT4 nuclear models for 160 MeV protons stopping in CH2. Med Phys. 2003 Jul; 30(7):1926-31.
Test of GEANT3 and GEANT4 nuclear models for 160 MeV protons stopping in CH2.
Significance and implementation of RBE variations in proton beam therapy. Technol Cancer Res Treat. 2003 Oct; 2(5):413-26.
Significance and implementation of RBE variations in proton beam therapy.
Paganetti H, Jiang H, Adams JA, Chen GT, Rietzel E
Monte Carlo simulations with time-dependent geometries to investigate effects of organ motion with high temporal resolution. Int J Radiat Oncol Biol Phys. 2004 Nov 01; 60(3):942-50.
Monte Carlo simulations with time-dependent geometries to investigate effects of organ motion with high temporal resolution.
Underwood TS, Sung W, McFadden CH, McMahon SJ, Hall DC, McNamara AL, Paganetti H, Sawakuchi GO, Schuemann J
Comparing stochastic proton interactions simulated using TOPAS-nBio to experimental data from fluorescent nuclear track detectors. Phys Med Biol. 2017 04 21; 62(8):3237-3249.
Comparing stochastic proton interactions simulated using TOPAS-nBio to experimental data from fluorescent nuclear track detectors.
Changes in tumor cell response due to prolonged dose delivery times in fractionated radiation therapy. Int J Radiat Oncol Biol Phys. 2005 Nov 01; 63(3):892-900.
Changes in tumor cell response due to prolonged dose delivery times in fractionated radiation therapy.
Calculation of the spatial variation of relative biological effectiveness in a therapeutic proton field for eye treatment. Phys Med Biol. 1998 Aug; 43(8):2147-57.
Calculation of the spatial variation of relative biological effectiveness in a therapeutic proton field for eye treatment.
International journal of radiation biology
The general relation between tissue response to x-radiation (alpha/beta-values) and the relative biological effectiveness (RBE) of protons: prediction by the Katz track-structure model. Int J Radiat Biol. 2000 Jul; 76(7):985-98.
The general relation between tissue response to x-radiation (alpha/beta-values) and the relative biological effectiveness (RBE) of protons: prediction by the Katz track-structure model.
Sung W, Ye SJ, McNamara AL, McMahon SJ, Hainfeld J, Shin J, Smilowitz HM, Paganetti H, Schuemann J
Dependence of gold nanoparticle radiosensitization on cell geometry. Nanoscale. 2017 May 11; 9(18):5843-5853.
Dependence of gold nanoparticle radiosensitization on cell geometry.
Paganetti H, Olko P, Kobus H, Becker R, Schmitz T, Waligorski MP, Filges D, Müller-Gärtner HW
Calculation of relative biological effectiveness for proton beams using biological weighting functions. Int J Radiat Oncol Biol Phys. 1997 Feb 01; 37(3):719-29.
Calculation of relative biological effectiveness for proton beams using biological weighting functions.
Comparison of MCNPX and Geant4 proton energy deposition predictions for clinical use. Phys Med Biol. 2012 Oct 21; 57(20):6381-93.
Comparison of MCNPX and Geant4 proton energy deposition predictions for clinical use.
Seco J, Sharp GC, Turcotte J, Gierga D, Bortfeld T, Paganetti H
Effects of organ motion on IMRT treatments with segments of few monitor units. Med Phys. 2007 Mar; 34(3):923-34.
Effects of organ motion on IMRT treatments with segments of few monitor units.
Accurate Monte Carlo simulations for nozzle design, commissioning and quality assurance for a proton radiation therapy facility. Med Phys. 2004 Jul; 31(7):2107-18.
Accurate Monte Carlo simulations for nozzle design, commissioning and quality assurance for a proton radiation therapy facility.
Interpretation of proton relative biological effectiveness using lesion induction, lesion repair, and cellular dose distribution. Med Phys. 2005 Aug; 32(8):2548-56.
Interpretation of proton relative biological effectiveness using lesion induction, lesion repair, and cellular dose distribution.
Min C, Zhu X, Grogg K, Winey B, Fakhri G, Bortfeld T, Shih H, Paganetti H
MO-A-213AB-07: Evaluation of Distal Dose Surface with In-Room PET for Proton Therapy Monitoring. Med Phys. 2012 Jun; 39(6Part20):3860.
MO-A-213AB-07: Evaluation of Distal Dose Surface with In-Room PET for Proton Therapy Monitoring.
Perl J, Shin J, Schuemann J, Faddegon B, Paganetti H
SU-E-T-473: Performance Assessment of the TOPAS Tool for Particle Simulation for Proton Therapy Applications. Med Phys. 2012 Jun; 39(6Part17):3814.
SU-E-T-473: Performance Assessment of the TOPAS Tool for Particle Simulation for Proton Therapy Applications.
Schuemann J, Testa M, Bueno M, Min C, Moteabbed M, Giantsoudi D, Paganetti H
SU-E-T-451: Patient and Site-Specific Assessment of the Value of Routine Monte Carlo Dose Calculation in Proton Therapy. Med Phys. 2013 Jun; 40(6Part17):309.
SU-E-T-451: Patient and Site-Specific Assessment of the Value of Routine Monte Carlo Dose Calculation in Proton Therapy.
Schuemann J, Dowdell S, Barbone G, Paganetti H
SU-E-T-404: Quantification of Proton Dose Enhancement Resulting From Gold Nanoparticles. Med Phys. 2013 Jun; 40(6Part17):297.
SU-E-T-404: Quantification of Proton Dose Enhancement Resulting From Gold Nanoparticles.
Paganetti H, Moteabbed M, Athar B, Adams J, Schneider U, Yock T
SU-E-T-258: Assessment of Radiation Induced Second Cancer Risks in Proton Therapy and IMRT for Organs inside the Main Radiation Field. Med Phys. 2012 Jun; 39(6Part13):3762-3763.
SU-E-T-258: Assessment of Radiation Induced Second Cancer Risks in Proton Therapy and IMRT for Organs inside the Main Radiation Field.
Beddar S, Deye J, Romeijn E, Mackie T, Paganetti H, Jin J, McGuire S
WE-E-116-01: Grantsmanship and Funding. Med Phys. 2013 Jun; 40(6Part30):497.
Phillips J, Gueorguiev G, Shackleford J, Grassberger C, Dowdell S, Paganetti H, Sharp G
TU-A-108-06: Computing Proton Dose to Irregularly Moving Targets. Med Phys. 2013 Jun; 40(6Part25):420.
TU-A-108-06: Computing Proton Dose to Irregularly Moving Targets.
TU-A-108-10: Pencil Beam Scanning Vs. Passive Scattered Proton Therapy for Pediatric Thoracic/pelvic Cancers. Med Phys. 2013 Jun; 40(6Part25):421.
TU-A-108-10: Pencil Beam Scanning Vs. Passive Scattered Proton Therapy for Pediatric Thoracic/pelvic Cancers.
Ramos-Mendez J, Perl J, Schuemann J, Shin J, Faddegon B, Paganetti H
WE-C-108-07: Optimal Parameters for Variance Reduction in Monte Carlo Simulations for Proton Therapy. Med Phys. 2013 Jun; 40(6Part28):475.
WE-C-108-07: Optimal Parameters for Variance Reduction in Monte Carlo Simulations for Proton Therapy.
Bueno M, Schuemann J, Duch M, Paganetti H
MO-F-BRB-03: A Method to Assess the Need for Clinical Monte Carlo Dose Calculations for Small Proton Therapy Fields. Med Phys. 2012 Jun; 39(6Part21):3874.
MO-F-BRB-03: A Method to Assess the Need for Clinical Monte Carlo Dose Calculations for Small Proton Therapy Fields.
Zeng C, Giantsoudi D, Grassberger C, Goldberg S, Niemierko A, Paganetti H, Trofimov A
SU-E-T-552: Maximizing the Biological Effect of Proton Dose Delivered with Scanned Beam. Med Phys. 2012 Jun; 39(6Part18):3832.
SU-E-T-552: Maximizing the Biological Effect of Proton Dose Delivered with Scanned Beam.
Perl J, Shin J, Schuemann J, Paganetti H, Faddegon B
TU-A-108-01: Four-Dimensional Monte Carlo Using the TOPAS TOol for PArticle Simulation. Med Phys. 2013 Jun; 40(6Part25):419.
TU-A-108-01: Four-Dimensional Monte Carlo Using the TOPAS TOol for PArticle Simulation.
SU-F-500-04: Motion Mitigation in Active Scanning Proton Therapy for Lung Cancer: A 4D Monte Carlo Study. Med Phys. 2013 Jun; 40(6Part23):383.
SU-F-500-04: Motion Mitigation in Active Scanning Proton Therapy for Lung Cancer: A 4D Monte Carlo Study.
Dowdell S, Clasie B, Depauw N, Metcalfe P, Rosenfeld A, Kooy H, Flanz J, Paganetti H
MO-F-213AB-03: Potential Reduction in Out-Of-Field Dose in Pencil Beam Scanning Proton Therapy Through Use of a Patient-Specific Aperture. Med Phys. 2012 Jun; 39(6Part21):3872.
MO-F-213AB-03: Potential Reduction in Out-Of-Field Dose in Pencil Beam Scanning Proton Therapy Through Use of a Patient-Specific Aperture.
Giantsoudi D, Unkelbach J, Craft D, Zeng C, Trofimov A, Paganetti H
TH-A-116-02: Radiobiological Implications of Various Target and Beam Geometry Utilization in Treatment Planning for Intensity Modulated Proton Therapy. Med Phys. 2013 Jun; 40(6Part32):529.
TH-A-116-02: Radiobiological Implications of Various Target and Beam Geometry Utilization in Treatment Planning for Intensity Modulated Proton Therapy.
TU-G-BRCD-02: Do Uncertainties in Proton Therapy Limit Its Clinical Potential? Med Phys. 2012 Jun; 39(6Part24):3918-3919.
TU-G-BRCD-02: Do Uncertainties in Proton Therapy Limit Its Clinical Potential?
SU-E-T-124: Assessing Quality Assurance of Proton Scattering Nozzles Using Monte Carlo. Med Phys. 2013 Jun; 40(6Part12):232.
SU-E-T-124: Assessing Quality Assurance of Proton Scattering Nozzles Using Monte Carlo.
Jia X, Schuemann J, Paganetti H, Jiang S
WE-F-105-03: Development of GPMC V2.0, a GPU-Based Monte Carlo Dose Calculation Package for Proton Radiotherapy. Med Phys. 2013 Jun; 40(6Part30):498.
WE-F-105-03: Development of GPMC V2.0, a GPU-Based Monte Carlo Dose Calculation Package for Proton Radiotherapy.
SU-E-T-495: Monte Carlo Dose Verification of Passive Scattering Proton Therapy for Prostate Cancer. Med Phys. 2012 Jun; 39(6Part17):3819.
SU-E-T-495: Monte Carlo Dose Verification of Passive Scattering Proton Therapy for Prostate Cancer.
Testa M, Bentefour H, Rose M, Paganetti H, Lu H
MO-A-213AB-08: 2D Water Equivalent Path Length Imaging Technique for Pre-Treatment Range Verification in Proton Therapy. Med Phys. 2012 Jun; 39(6Part20):3860.
MO-A-213AB-08: 2D Water Equivalent Path Length Imaging Technique for Pre-Treatment Range Verification in Proton Therapy.
SU-E-T-470: Comparison of Proton Treatment Planning and Monte Carlo Calculation Using TOPAS for Liver Cancer. Med Phys. 2012 Jun; 39(6Part17):3813.
SU-E-T-470: Comparison of Proton Treatment Planning and Monte Carlo Calculation Using TOPAS for Liver Cancer.
Ramos-Mendez J, Perl J, Faddegon B, Paganetti H
SU-E-T-478: Geometrical Splitting Technique to Improve the Computational Efficiency in Monte Carlo Calculations for Proton Therapy. Med Phys. 2012 Jun; 39(6Part17):3815.
SU-E-T-478: Geometrical Splitting Technique to Improve the Computational Efficiency in Monte Carlo Calculations for Proton Therapy.
TU-A-108-02: A 4D Monte Carlo Study Quantifying Changes in the Interplay Effect as a Function of Treatment Delivery Parameters in Proton Beam Scanning for Lung. Med Phys. 2013 Jun; 40(6Part25):419-420.
TU-A-108-02: A 4D Monte Carlo Study Quantifying Changes in the Interplay Effect as a Function of Treatment Delivery Parameters in Proton Beam Scanning for Lung.
Grassberger C, Daartz J, Dowdell S, Verburg J, Sharp G, Paganetti H
MO-G-137-02: Experimental Validation of Clinical as Well as Monte Carlo Dose Calculation for Proton Therapy of Lung Cancer Patients. Med Phys. 2013 Jun; 40(6Part25):416.
MO-G-137-02: Experimental Validation of Clinical as Well as Monte Carlo Dose Calculation for Proton Therapy of Lung Cancer Patients.
Parodi K, Polf J, Paganetti H, Schulte R
WE-A-WAB-01: New Technologies Addressing the Range Uncertainty of Proton Therapy. Med Phys. 2013 Jun; 40(6Part28):468.
WE-A-WAB-01: New Technologies Addressing the Range Uncertainty of Proton Therapy.
TU-A-108-08: Comparison of Full Intensity Modulated and Single Field Uniform Dose Proton Beam Scanning Lung Treatments. Med Phys. 2013 Jun; 40(6Part25):421.
TU-A-108-08: Comparison of Full Intensity Modulated and Single Field Uniform Dose Proton Beam Scanning Lung Treatments.
Schuemann J, Shin J, Perl J, Grassberger C, Verburg J, Faddegon B, Paganetti H
SU-E-T-500: Pencil-Beam versus Monte Carlo Based Dose Calculation for Proton Therapy Patients with Complex Geometries. Clinical Use of the TOPAS Monte Carlo System. Med Phys. 2012 Jun; 39(6Part18):3820.
SU-E-T-500: Pencil-Beam versus Monte Carlo Based Dose Calculation for Proton Therapy Patients with Complex Geometries. Clinical Use of the TOPAS Monte Carlo System.
Testa M, Min C, Schuemann J, Verburg J, Lu H, Paganetti H
WE-G-500-04: A Novel Technique for In-Vivo and Real-Time Range Verification Based On the Characteristic Prompt Gamma Time-Structure of Passively Modulated Proton Beams. Med Phys. 2013 Jun; 40(6Part30):503.
WE-G-500-04: A Novel Technique for In-Vivo and Real-Time Range Verification Based On the Characteristic Prompt Gamma Time-Structure of Passively Modulated Proton Beams.
Huenemohr N, Paganetti H, Greilich S, Jaekel O, Seco J
TH-C-144-03: Tissue Decomposition From Dual Energy CT Data to Reduce Range Uncertainties in Proton and Carbon Radiotherapy. Med Phys. 2013 Jun; 40(6Part33):546.
TH-C-144-03: Tissue Decomposition From Dual Energy CT Data to Reduce Range Uncertainties in Proton and Carbon Radiotherapy.
Dosimetric accuracy of planning and delivering small proton therapy fields. Phys Med Biol. 2010 Dec 21; 55(24):7425-38.
Dosimetric accuracy of planning and delivering small proton therapy fields.
Australasian physical & engineering sciences in medicine
Monte Carlo calculations in support of the commissioning of the Northeast Proton Therapy Center. Australas Phys Eng Sci Med. 2003 Dec; 26(4):156-61.
Monte Carlo calculations in support of the commissioning of the Northeast Proton Therapy Center.
A review of dosimetry studies on external-beam radiation treatment with respect to second cancer induction. Phys Med Biol. 2008 Jul 07; 53(13):R193-241.
A review of dosimetry studies on external-beam radiation treatment with respect to second cancer induction.
Ramos-Méndez J, Schuemann J, Incerti S, Paganetti H, Schulte R, Faddegon B
Flagged uniform particle splitting for variance reduction in proton and carbon ion track-structure simulations. Phys Med Biol. 2017 Jul 06; 62(15):5908-5925.
Flagged uniform particle splitting for variance reduction in proton and carbon ion track-structure simulations.
Giantsoudi D, Seco J, Eaton BR, Simeone FJ, Kooy H, Yock TI, Tarbell NJ, DeLaney TF, Adams J, Paganetti H, MacDonald SM
Evaluating Intensity Modulated Proton Therapy Relative to Passive Scattering Proton Therapy for Increased Vertebral Column Sparing in Craniospinal Irradiation in Growing Pediatric Patients. Int J Radiat Oncol Biol Phys. 2017 05 01; 98(1):37-46.
Evaluating Intensity Modulated Proton Therapy Relative to Passive Scattering Proton Therapy for Increased Vertebral Column Sparing in Craniospinal Irradiation in Growing Pediatric Patients.
Sorriaux J, Testa M, Paganetti H, Orban de Xivry J, Lee JA, Traneus E, Souris K, Vynckier S, Sterpin E
Experimental assessment of proton dose calculation accuracy in inhomogeneous media. Phys Med. 2017 Jun; 38:10-15.
Experimental assessment of proton dose calculation accuracy in inhomogeneous media.
Suit H, Kooy H, Trofimov A, Farr J, Munzenrider J, DeLaney T, Loeffler J, Clasie B, Safai S, Paganetti H
Should positive phase III clinical trial data be required before proton beam therapy is more widely adopted? No. Radiother Oncol. 2008 Feb; 86(2):148-53.
Should positive phase III clinical trial data be required before proton beam therapy is more widely adopted? No.
Neutron equivalent doses and associated lifetime cancer incidence risks for head & neck and spinal proton therapy. Phys Med Biol. 2009 Aug 21; 54(16):4907-26.
Neutron equivalent doses and associated lifetime cancer incidence risks for head & neck and spinal proton therapy.
Knopf A, Parodi K, Paganetti H, Cascio E, Bonab A, Bortfeld T
Quantitative assessment of the physical potential of proton beam range verification with PET/CT. Phys Med Biol. 2008 Aug 07; 53(15):4137-51.
Quantitative assessment of the physical potential of proton beam range verification with PET/CT.
Sorriaux J, Testa M, Paganetti H, Bertrand D, Lee JA, Palmans H, Vynckier S, Sterpin E
Consistency in quality correction factors for ionization chamber dosimetry in scanned proton beam therapy. Med Phys. 2017 Sep; 44(9):4919-4927.
Consistency in quality correction factors for ionization chamber dosimetry in scanned proton beam therapy.
Gensheimer MF, Yock TI, Liebsch NJ, Sharp GC, Paganetti H, Madan N, Grant PE, Bortfeld T
In vivo proton beam range verification using spine MRI changes. Int J Radiat Oncol Biol Phys. 2010 Sep 01; 78(1):268-75.
In vivo proton beam range verification using spine MRI changes.
Four-dimensional Monte Carlo simulation of time-dependent geometries. Phys Med Biol. 2004 Mar 21; 49(6):N75-81.
Four-dimensional Monte Carlo simulation of time-dependent geometries.
Kry SF, Bednarz B, Howell RM, Dauer L, Followill D, Klein E, Paganetti H, Wang B, Wuu CS, George Xu X
AAPM TG 158: Measurement and calculation of doses outside the treated volume from external-beam radiation therapy. Med Phys. 2017 Oct; 44(10):e391-e429.
AAPM TG 158: Measurement and calculation of doses outside the treated volume from external-beam radiation therapy.
Sensitivity of different dose scoring methods on organ-specific neutron dose calculations in proton therapy. Phys Med Biol. 2008 Sep 07; 53(17):4523-32.
Sensitivity of different dose scoring methods on organ-specific neutron dose calculations in proton therapy.
The influence of the beam modulation technique on dose and RBE in proton radiation therapy. Phys Med Biol. 1996 Sep; 41(9):1649-63.
The influence of the beam modulation technique on dose and RBE in proton radiation therapy.
Butterworth KT, McGarry CK, Clasie B, Carabe-Fernandez A, Schuemann J, Depauw N, Tang S, McMahon SJ, Schettino G, O'Sullivan JM, Lu HM, Kooy H, Paganetti H, Hounsell AR, Held KD, Prise KM
Relative biological effectiveness (RBE) and out-of-field cell survival responses to passive scattering and pencil beam scanning proton beam deliveries. Phys Med Biol. 2012 Oct 21; 57(20):6671-80.
Relative biological effectiveness (RBE) and out-of-field cell survival responses to passive scattering and pencil beam scanning proton beam deliveries.
Nuclear interactions of 160 MeV protons stopping in copper: a test of Monte Carlo nuclear models. Med Phys. 1999 Dec; 26(12):2597-601.
Nuclear interactions of 160 MeV protons stopping in copper: a test of Monte Carlo nuclear models.
Henkner K, Sobolevsky N, Jäkel O, Paganetti H
Test of the nuclear interaction model in SHIELD-HIT and comparison to energy distributions from GEANT4. Phys Med Biol. 2009 Nov 21; 54(22):N509-17.
Test of the nuclear interaction model in SHIELD-HIT and comparison to energy distributions from GEANT4.
Spread-out antiproton beams deliver poor physical dose distributions for radiation therapy. Radiother Oncol. 2010 Apr; 95(1):79-86.
Spread-out antiproton beams deliver poor physical dose distributions for radiation therapy.
The impact of uncertainties in the CT conversion algorithm when predicting proton beam ranges in patients from dose and PET-activity distributions. Phys Med Biol. 2010 Dec 21; 55(24):7557-71.
The impact of uncertainties in the CT conversion algorithm when predicting proton beam ranges in patients from dose and PET-activity distributions.
Paganetti H, Athar BS, Moteabbed M, A Adams J, Schneider U, Yock TI
Assessment of radiation-induced second cancer risks in proton therapy and IMRT for organs inside the primary radiation field. Phys Med Biol. 2012 Oct 07; 57(19):6047-61.
Assessment of radiation-induced second cancer risks in proton therapy and IMRT for organs inside the primary radiation field.
Min CH, Zhu X, Winey BA, Grogg K, Testa M, El Fakhri G, Bortfeld TR, Paganetti H, Shih HA
Clinical application of in-room positron emission tomography for in vivo treatment monitoring in proton radiation therapy. Int J Radiat Oncol Biol Phys. 2013 May 01; 86(1):183-9.
Clinical application of in-room positron emission tomography for in vivo treatment monitoring in proton radiation therapy.
Correction: Dependence of gold nanoparticle radiosensitization on cell geometry. Nanoscale. 2017 08 10; 9(31):11338.
Correction: Dependence of gold nanoparticle radiosensitization on cell geometry.
Predicting Organ-Specific Risk Interactions between Radiation and Chemotherapy in Secondary Cancer Survivors. Cancers (Basel). 2017 Sep 06; 9(9).
Predicting Organ-Specific Risk Interactions between Radiation and Chemotherapy in Secondary Cancer Survivors.
Tran LT, Chartier L, Bolst D, Pogossov A, Guatelli S, Petasecca M, Lerch MLF, Prokopovich DA, Reinhard MI, Clasie B, Depauw N, Kooy H, Flanz JB, McNamara A, Paganetti H, Beltran C, Furutani K, Perevertaylo VL, Jackson M, Rosenfeld AB
Characterization of proton pencil beam scanning and passive beam using a high spatial resolution solid-state microdosimeter. Med Phys. 2017 Nov; 44(11):6085-6095.
Characterization of proton pencil beam scanning and passive beam using a high spatial resolution solid-state microdosimeter.
McMahon SJ, McNamara AL, Schuemann J, Paganetti H, Prise KM
A general mechanistic model enables predictions of the biological effectiveness of different qualities of radiation. Sci Rep. 2017 09 07; 7(1):10790.
A general mechanistic model enables predictions of the biological effectiveness of different qualities of radiation.
Kooy HM, Rosenthal SJ, Engelsman M, Mazal A, Slopsema RL, Paganetti H, Flanz JB
The prediction of output factors for spread-out proton Bragg peak fields in clinical practice. Phys Med Biol. 2005 Dec 21; 50(24):5847-56.
The prediction of output factors for spread-out proton Bragg peak fields in clinical practice.
Relating the proton relative biological effectiveness to tumor control and normal tissue complication probabilities assuming interpatient variability in a/ß. Acta Oncol. 2017 Nov; 56(11):1379-1386.
Relating the proton relative biological effectiveness to tumor control and normal tissue complication probabilities assuming interpatient variability in a/ß.
Biophysical modelling of proton radiation effects based on amorphous track models. Int J Radiat Biol. 2001 Sep; 77(9):911-28.
Biophysical modelling of proton radiation effects based on amorphous track models.
Paganetti H, Niemierko A, Ancukiewicz M, Gerweck LE, Goitein M, Loeffler JS, Suit HD
Relative biological effectiveness (RBE) values for proton beam therapy. Int J Radiat Oncol Biol Phys. 2002 Jun 01; 53(2):407-21.
Relative biological effectiveness (RBE) values for proton beam therapy.
Prediction of Treatment Response for Combined Chemo- and Radiation Therapy for Non-Small Cell Lung Cancer Patients Using a Bio-Mathematical Model. Sci Rep. 2017 10 19; 7(1):13542.
Prediction of Treatment Response for Combined Chemo- and Radiation Therapy for Non-Small Cell Lung Cancer Patients Using a Bio-Mathematical Model.
Dose-rate effects when estimating risks for second malignancies: in regard to Fontenot et al (Int J Radiat Oncol Biol Phys 2009;74:616-622). Int J Radiat Oncol Biol Phys. 2009 Dec 01; 75(5):1624; author reply 1624-5.
Dose-rate effects when estimating risks for second malignancies: in regard to Fontenot et al (Int J Radiat Oncol Biol Phys 2009;74:616-622).
Better radiation weighting factors for neutrons generated from proton treatment are needed. Radiat Prot Dosimetry. 2010 Mar; 138(4):291-4.
Better radiation weighting factors for neutrons generated from proton treatment are needed.
Monte Carlo patient study on the comparison of prompt gamma and PET imaging for range verification in proton therapy. Phys Med Biol. 2011 Feb 21; 56(4):1063-82.
Monte Carlo patient study on the comparison of prompt gamma and PET imaging for range verification in proton therapy.
España S, Zhu X, Daartz J, El Fakhri G, Bortfeld T, Paganetti H
The reliability of proton-nuclear interaction cross-section data to predict proton-induced PET images in proton therapy. Phys Med Biol. 2011 May 07; 56(9):2687-98.
The reliability of proton-nuclear interaction cross-section data to predict proton-induced PET images in proton therapy.
Remmele S, Hesser J, Paganetti H, Bortfeld T
A deconvolution approach for PET-based dose reconstruction in proton radiotherapy. Phys Med Biol. 2011 Dec 07; 56(23):7601-19.
A deconvolution approach for PET-based dose reconstruction in proton radiotherapy.
Dowdell SJ, Clasie B, Depauw N, Metcalfe P, Rosenfeld AB, Kooy HM, Flanz JB, Paganetti H
Monte Carlo study of the potential reduction in out-of-field dose using a patient-specific aperture in pencil beam scanning proton therapy. Phys Med Biol. 2012 May 21; 57(10):2829-42.
Monte Carlo study of the potential reduction in out-of-field dose using a patient-specific aperture in pencil beam scanning proton therapy.
Toltz A, Hoesl M, Schuemann J, Seuntjens J, Lu HM, Paganetti H
Journal of applied clinical medical physics
Time-resolved diode dosimetry calibration through Monte Carlo modeling for in vivo passive scattered proton therapy range verification. J Appl Clin Med Phys. 2017 Nov; 18(6):200-205.
Time-resolved diode dosimetry calibration through Monte Carlo modeling for in vivo passive scattered proton therapy range verification.
Grassberger C, Trofimov A, Lomax A, Paganetti H
Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning. Int J Radiat Oncol Biol Phys. 2011 Aug 01; 80(5):1559-66.
Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning.
4D Monte Carlo simulation of proton beam scanning: modelling of variations in time and space to study the interplay between scanning pattern and time-dependent patient geometry. Phys Med Biol. 2005 Mar 07; 50(5):983-90.
4D Monte Carlo simulation of proton beam scanning: modelling of variations in time and space to study the interplay between scanning pattern and time-dependent patient geometry.
Zacharatou Jarlskog C, Lee C, Bolch WE, Xu XG, Paganetti H
Assessment of organ-specific neutron equivalent doses in proton therapy using computational whole-body age-dependent voxel phantoms. Phys Med Biol. 2008 Feb 07; 53(3):693-717.
Assessment of organ-specific neutron equivalent doses in proton therapy using computational whole-body age-dependent voxel phantoms.
Jia X, Schümann J, Paganetti H, Jiang SB
GPU-based fast Monte Carlo dose calculation for proton therapy. Phys Med Biol. 2012 Dec 07; 57(23):7783-97.
GPU-based fast Monte Carlo dose calculation for proton therapy.
Botas P, Grassberger C, Sharp G, Paganetti H
Density overwrites of internal tumor volumes in intensity modulated proton therapy plans for mobile lung tumors. Phys Med Biol. 2018 01 30; 63(3):035023.
Density overwrites of internal tumor volumes in intensity modulated proton therapy plans for mobile lung tumors.
Knopf A, Parodi K, Bortfeld T, Shih HA, Paganetti H
Systematic analysis of biological and physical limitations of proton beam range verification with offline PET/CT scans. Phys Med Biol. 2009 Jul 21; 54(14):4477-95.
Systematic analysis of biological and physical limitations of proton beam range verification with offline PET/CT scans.
Daartz J, Engelsman M, Paganetti H, Bussière MR
Field size dependence of the output factor in passively scattered proton therapy: influence of range, modulation, air gap, and machine settings. Med Phys. 2009 Jul; 36(7):3205-10.
Field size dependence of the output factor in passively scattered proton therapy: influence of range, modulation, air gap, and machine settings.
Suit H, DeLaney T, Goldberg S, Paganetti H, Clasie B, Gerweck L, Niemierko A, Hall E, Flanz J, Hallman J, Trofimov A
Proton vs carbon ion beams in the definitive radiation treatment of cancer patients. Radiother Oncol. 2010 Apr; 95(1):3-22.
Proton vs carbon ion beams in the definitive radiation treatment of cancer patients.
Proton radiation in the management of localized cancer. Expert Rev Med Devices. 2010 Mar; 7(2):275-85.
Proton radiation in the management of localized cancer.
Clasie B, Wroe A, Kooy H, Depauw N, Flanz J, Paganetti H, Rosenfeld A
Assessment of out-of-field absorbed dose and equivalent dose in proton fields. Med Phys. 2010 Jan; 37(1):311-21.
Assessment of out-of-field absorbed dose and equivalent dose in proton fields.
Knopf AC, Parodi K, Paganetti H, Bortfeld T, Daartz J, Engelsman M, Liebsch N, Shih H
Accuracy of proton beam range verification using post-treatment positron emission tomography/computed tomography as function of treatment site. Int J Radiat Oncol Biol Phys. 2011 Jan 01; 79(1):297-304.
Accuracy of proton beam range verification using post-treatment positron emission tomography/computed tomography as function of treatment site.
Carabe-Fernandez A, Dale RG, Paganetti H
Repair kinetic considerations in particle beam radiotherapy. Br J Radiol. 2011 Jun; 84(1002):546-55.
Repair kinetic considerations in particle beam radiotherapy.
Elevated LET components in clinical proton beams. Phys Med Biol. 2011 Oct 21; 56(20):6677-91.
Elevated LET components in clinical proton beams.
The clinical impact of uncertainties in the mean excitation energy of human tissues during proton therapy. Phys Med Biol. 2013 Feb 21; 58(4):887-902.
The clinical impact of uncertainties in the mean excitation energy of human tissues during proton therapy.
Radiobiological significance of beamline dependent proton energy distributions in a spread-out Bragg peak. Med Phys. 2000 May; 27(5):1119-26.
Radiobiological significance of beamline dependent proton energy distributions in a spread-out Bragg peak.
Efstathiou JA, Paly JJ, Lu HM, Athar BS, Moteabbed M, Niemierko A, Adams JA, Bekelman JE, Shipley WU, Zietman AL, Paganetti H
Adjuvant radiation therapy for early stage seminoma: proton versus photon planning comparison and modeling of second cancer risk. Radiother Oncol. 2012 Apr; 103(1):12-7.
Adjuvant radiation therapy for early stage seminoma: proton versus photon planning comparison and modeling of second cancer risk.
Biological considerations when comparing proton therapy with photon therapy. Semin Radiat Oncol. 2013 Apr; 23(2):77-87.
Biological considerations when comparing proton therapy with photon therapy.