MCH8MarciaHaigisMarcia C. Haigis, Ph.D.42.33837200000000-71.1032690000000055186Haigis, MarciaC.Professor of Cell Biologycatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 104999616Authorship 10488671429466723Gonzalez Herrera KN, Zaganjor E, Ishikawa Y, Spinelli JB, Yoon H, Lin JR, Satterstrom FK, Ringel A, Mulei S, Souza A, Gorham JM, Benson CC, Seidman JG, Sorger PK, Clish CB, Haigis MCCell reportsSmall-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3. Cell Rep. 2018 02 20; 22(8):1945-1955.Cell Rep2018-02-20T00:00:002018Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3.29499131Escudero S, Zaganjor E, Lee S, Mill CP, Morgan AM, Crawford EB, Chen J, Wales TE, Mourtada R, Luccarelli J, Bird GH, Steidl U, Engen JR, Haigis MC, Opferman JT, Walensky LDMolecular cellDynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD. Mol Cell. 2018 03 01; 69(5):729-743.e7.Mol Cell2018-03-01T00:00:002018Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD.20863707Verdin E, Hirschey MD, Finley LW, Haigis MCTrends in biochemical sciencesSirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem Sci. 2010 Dec; 35(12):669-75.Trends Biochem Sci2010-09-20T00:00:002010Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling.19962456Lomb DJ, Laurent G, Haigis MCBiochimica et biophysica actaSirtuins regulate key aspects of lipid metabolism. Biochim Biophys Acta. 2010 Aug; 1804(8):1652-7.Biochim Biophys Acta2009-12-02T00:00:002009Sirtuins regulate key aspects of lipid metabolism.KK317KiranKurmiKiran Kurmi, Ph.D.169435Kurmi, KiranResearch Fellow in Cell Biology22308395Finley LW, Lee J, Souza A, Desquiret-Dumas V, Bullock K, Rowe GC, Procaccio V, Clish CB, Arany Z, Haigis MCProceedings of the National Academy of Sciences of the United States of AmericaSkeletal muscle transcriptional coactivator PGC-1a mediates mitochondrial, but not metabolic, changes during calorie restriction. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2931-6.Proc Natl Acad Sci U S A2012-02-03T00:00:002012Skeletal muscle transcriptional coactivator PGC-1a mediates mitochondrial, but not metabolic, changes during calorie restriction.Authorship 10746771429915029Lee JJ, van de Ven RAH, Zaganjor E, Ng MR, Barakat A, Demmers JJPG, Finley LWS, Gonzalez Herrera KN, Hung YP, Harris IS, Jeong SM, Danuser G, McAllister SS, Haigis MCProceedings of the National Academy of Sciences of the United States of AmericaInhibition of epithelial cell migration and Src/FAK signaling by SIRT3. Proc Natl Acad Sci U S A. 2018 07 03; 115(27):7057-7062.Proc Natl Acad Sci U S A2018-06-18T00:00:002018Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3.23535601Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, DePinho RA, Cantley LC, Kimmelman ACNatureGlutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 2013 Apr 04; 496(7443):101-5.Nature2013-03-27T00:00:002013Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.Authorship 1076044229950572Spinelli JB, Haigis MCNature cell biologyThe multifaceted contributions of mitochondria to cellular metabolism. Nat Cell Biol. 2018 07; 20(7):745-754.Nat Cell Biol2018-06-27T00:00:002018The multifaceted contributions of mitochondria to cellular metabolism.22401813Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PPCellSystemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell. 2012 Mar 30; 149(1):49-62.Cell2012-03-06T00:00:002012Systemic elevation of PTEN induces a tumor-suppressive metabolic state.17923681Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV, Weissman S, Verdin E, Schwer BMolecular and cellular biologyMammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007 Dec; 27(24):8807-14.Mol Cell Biol2007-10-08T00:00:002007Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.Authorship 10798061230022159Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ETNatureAccumulation of succinate controls activation of adipose tissue thermogenesis. Nature. 2018 08; 560(7716):102-106.Nature2018-07-18T00:00:002018Accumulation of succinate controls activation of adipose tissue thermogenesis.Authorship 10916821230190193Adachi Y, De Sousa-Coelho AL, Harata I, Aoun C, Weimer S, Shi X, Gonzalez Herrera KN, Takahashi H, Doherty C, Noguchi Y, Goodyear LJ, Haigis MC, Gerszten RE, Patti MEMolecular metabolisml-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism. Mol Metab. 2018 11; 17:61-70.Mol Metab2018-08-11T00:00:002018l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism.Authorship 10945131730220459McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WGCellTransaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. Cell. 2018 09 20; 175(1):101-116.e25.Cell2018-09-13T00:00:002018Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.Authorship 1372125Authorship 1115384330444998Ringel AE, Tucker SA, Haigis MCMolecular cellChemical and Physiological Features of Mitochondrial Acylation. Mol Cell. 2018 11 15; 72(4):610-624.Mol Cell2018-11-15T00:00:002018Chemical and Physiological Features of Mitochondrial Acylation.18372904Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks TNature geneticsDifferential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet. 2008 May; 40(5):600-8.Nat Genet2008-03-30T00:00:002008Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.20965426Haigis MC, Yankner BAMolecular cellThe aging stress response. Mol Cell. 2010 Oct 22; 40(2):333-44.Mol Cell2010-10-22T00:00:002010The aging stress response.21397863Finley LW, Carracedo A, Lee J, Souza A, Egia A, Zhang J, Teruya-Feldstein J, Moreira PI, Cardoso SM, Clish CB, Pandolfi PP, Haigis MCCancer cellSIRT3 opposes reprogramming of cancer cell metabolism through HIF1a destabilization. Cancer Cell. 2011 Mar 08; 19(3):416-28.Cancer Cell2011-03-08T00:00:002011SIRT3 opposes reprogramming of cancer cell metabolism through HIF1a destabilization.Authorship 11206641130530686Ron-Harel N, Notarangelo G, Ghergurovich JM, Paulo JA, Sage PT, Santos D, Satterstrom FK, Gygi SP, Rabinowitz JD, Sharpe AH, Haigis MCProceedings of the National Academy of Sciences of the United States of AmericaDefective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):13347-13352.Proc Natl Acad Sci U S A2018-12-10T00:00:002018Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice.22770219Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, Wei WCellAcetylation-dependent regulation of Skp2 function. Cell. 2012 Jul 06; 150(1):179-93.Cell2012-07-06T00:00:002012Acetylation-dependent regulation of Skp2 function.2020-02-29HAIGIS, MARCIA2019-03-15Frontiers of Aging: From Molecules to PhysiologyR13AG063483Principal InvestigatorAuthorship 11348581530872525Chakraborty AA, Laukka T, Myllykoski M, Ringel AE, Booker MA, Tolstorukov MY, Meng YJ, Meier SR, Jennings RB, Creech AL, Herbert ZT, McBrayer SK, Olenchock BA, Jaffe JD, Haigis MC, Beroukhim R, Signoretti S, Koivunen P, Kaelin WGScience (New York, N.Y.)Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate. Science. 2019 03 15; 363(6432):1217-1222.Science2019-03-14T00:00:002019Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate.D056566Chemicals & Drugs40680.930174Sirtuin 3D037761Chemicals & Drugs1353210.780026SirtuinsD024101Chemicals & Drugs4999890.616644Mitochondrial ProteinsMGH Cancer Center ResearchAuthorship 1458575D008928AnatomyPhysiology145235220.381918MitochondriaD007109Physiology70810080.618432ImmunityCell BiologyEmeritusGeneticsMedicineSystems BiologyMCB Board of TutorJoslinImmunologyDana-Farber Cancer InstituteFaculty of Arts & SciencesHarvard Medical SchoolJoslin Diabetes CenterMassachusetts General HospitalVKM1VamsiMoothaVamsi Krishna Mootha, M.D.42.36125700000000-71.0655270000000024390Mootha, VamsiProfessor of Systems BiologyPKS5PeterSorgerPeter Karl Sorger, Ph.D.42.33594500000000-71.102958000000006970Sorger, PeterOtto Krayer Professor of Systems PharmacologyAuthorship 11549201231078528Wang H, Sheehan RP, Palmer AC, Everley RA, Boswell SA, Ron-Harel N, Ringel AE, Holton KM, Jacobson CA, Erickson AR, Maliszewski L, Haigis MC, Sorger PKCell systemsAdaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming. Cell Syst. 2019 05 22; 8(5):412-426.e7.Cell Syst2019-05-08T00:00:002019Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming.COB1ChristopheBenoistChristophe O. Benoist, M.D., Ph.D.42.33837200000000-71.1032690000000050413Benoist, ChristopheMorton Grove-Rasmussen Professor of ImmunohematologyAT113AudeThiriotAude Thiriot, Ph.D.42.33837200000000-71.1032690000000052094Thiriot, AudeResearch Associate in ImmunologyPPB1PerePuigserverPere Puigserver, Ph.D.42.33789600000000-71.1072493000000019794Puigserver, PereProfessor of Cell BiologyRM40RaulMostoslavskyRaul Mostoslavsky, M.D., Ph.D.42.36125700000000-71.0655270000000078884Mostoslavsky, RaulLaurel Schwartz Professor of Medicine in the Field of OncologySPG4StevenGygiSteven P. Gygi, Ph.D.42.33588600000000-71.1051460000000028969Gygi, StevenProfessor of Cell Biology11124selected publications6.865280.00289204549research areas3.292690.0164965129coauthor of112.0418.108760similar toCRK3C.KahnC. Ronald Kahn, M.D.42.33839600000000-71.1084030000000084269Kahn, C.Mary K. Iacocca Professor of MedicineDER3DavidReichDavid Emil Reich, D.Phil.42.33837200000000-71.1032690000000047208Reich, DavidProfessor of GeneticsJWH11WadeHarperWade Harper, Ph.D.42.33837200000000-71.1032690000000020290Harper, WadeBert and Natalie Vallee Professor of Molecular PathologyJFR1JamesRiordanJames Francis Riordan, Ph.D.42.33837200000000-71.103269000000005827Riordan, JamesProfessor of Biochemistry , EmeritusAHS1ArleneSharpeArlene Helen Sharpe, M.D., Ph.D.42.33837200000000-71.1032690000000068774Sharpe, ArleneKolokotrones University ProfessorCY130ConghuiYaoConghui Yao, Ph.D.181096Yao, ConghuiResearch Fellow in Cell Biology23562301Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K, Li YH, Wang X, Laurent G, German NJ, Xu X, Li C, Wang RH, Lee J, Csibi A, Cerione R, Blenis J, Clish CB, Kimmelman A, Deng CX, Haigis MCCancer cellSIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell. 2013 Apr 15; 23(4):450-63.Cancer Cell2013-04-04T00:00:002013SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism.Authorship 1190218831533027Ron-Harel N, Ghergurovich JM, Notarangelo G, LaFleur MW, Tsubosaka Y, Sharpe AH, Rabinowitz JD, Haigis MCCell reportsT Cell Activation Depends on Extracellular Alanine. Cell Rep. 2019 09 17; 28(12):3011-3021.e4.Cell Rep2019-09-17T00:00:002019T Cell Activation Depends on Extracellular Alanine.true1Professor of Cell BiologyProfessor of Cell Biologytrue1Professor of Biochemistry , EmeritusProfessor of Biochemistry , Emeritustrue1Morton Grove-Rasmussen Professor of ImmunohematologyMorton Grove-Rasmussen Professor of Immunohematologytrue1Mary K. Iacocca Professor of MedicineMary K. Iacocca Professor of Medicinetrue1Laurel Schwartz Professor of Medicine in the Field of OncologyLaurel Schwartz Professor of Medicine in the Field of Oncology31767628Randall EC, Lopez BGC, Peng S, Regan MS, Abdelmoula WM, Basu SS, Santagata S, Yoon H, Haigis MC, Agar JN, Tran NL, Elmquist WF, White FM, Sarkaria JN, Agar NYRCancer researchLocalized Metabolomic Gradients in Patient-Derived Xenograft Models of Glioblastoma. Cancer Res. 2020 03 15; 80(6):1258-1267.Cancer Res2019-11-25T00:00:002019Localized Metabolomic Gradients in Patient-Derived Xenograft Models of Glioblastoma.Authorship 1334041Authorship 12075499Authorship 12082231331792987Cable J, Finley L, Tu BP, Patti GJ, Oliver TG, Vardhana S, Mana M, Ericksen R, Khare S, DeBerardinis R, Stockwell BR, Edinger A, Haigis M, Kaelin WAnnals of the New York Academy of SciencesLeveraging insights into cancer metabolism-a symposium report. Ann N Y Acad Sci. 2020 02; 1462(1):5-13.Ann N Y Acad Sci2019-12-02T00:00:002019Leveraging insights into cancer metabolism-a symposium report.Authorship 1211879231851904Notarangelo G, Haigis MCImmunitySweet Temptation: From Sugar Metabolism to Gene Regulation. Immunity. 2019 12 17; 51(6):980-981.Immunity2019-12-17T00:00:002019Sweet Temptation: From Sugar Metabolism to Gene Regulation.Clinical and Academic AffairsAuthorship 12394731432273287Qiao S, Koh SB, Vivekanandan V, Salunke D, Patra KC, Zaganjor E, Ross K, Mizukami Y, Jeanfavre S, Chen A, Mino-Kenudson M, Ramaswamy S, Clish C, Haigis M, Bardeesy N, Ellisen LWGenes & developmentREDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors. Genes Dev. 2020 06 01; 34(11-12):751-766.Genes Dev2020-04-09T00:00:002020REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors.32302552Kurmi K, Haigis MCTrends in cell biologyNitrogen Metabolism in Cancer and Immunity. Trends Cell Biol. 2020 05; 30(5):408-424.Trends Cell Biol2020-03-10T00:00:002020Nitrogen Metabolism in Cancer and Immunity.Authorship 12419552Authorship 1245316732371392Chen H, Shi Z, Guo J, Chang KJ, Chen Q, Yao CH, Haigis MC, Shi YThe Journal of biological chemistryThe human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for mitochondrial function. J Biol Chem. 2020 06 19; 295(25):8505-8513.J Biol Chem2020-05-05T00:00:002020The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for mitochondrial function.Authorship 12691861832663458Yoon H, Spinelli JB, Zaganjor E, Wong SJ, German NJ, Randall EC, Dean A, Clermont A, Paulo JA, Garcia D, Li H, Rombold O, Agar NYR, Goodyear LJ, Shaw RJ, Gygi SP, Auwerx J, Haigis MCCell metabolismPHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle. Cell Metab. 2020 08 04; 32(2):215-228.e7.Cell Metab2020-07-13T00:00:002020PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle.Authorship 12738021632763164van Gastel N, Spinelli JB, Sharda A, Schajnovitz A, Baryawno N, Rhee C, Oki T, Grace E, Soled HJ, Milosevic J, Sykes DB, Hsu PP, Vander Heiden MG, Vidoudez C, Trauger SA, Haigis MC, Scadden DTCell metabolismInduction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance. Cell Metab. 2020 09 01; 32(3):391-403.e6.Cell Metab2020-08-06T00:00:002020Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance.true1Professor of Cell BiologyProfessor of Cell BiologyAuthorship 1397391Authorship 1306665333170123Drijvers JM, Sharpe AH, Haigis MCeLifeThe effects of age and systemic metabolism on anti-tumor T cell responses. Elife. 2020 11 10; 9.Elife2020-11-10T00:00:002020The effects of age and systemic metabolism on anti-tumor T cell responses.Authorship 130843313Authorship 13089271333277233Drijvers JM, Gillis JE, Muijlwijk T, Nguyen TH, Gaudiano EF, Harris IS, LaFleur MW, Ringel AE, Yao CH, Kurmi K, Juneja VR, Trombley JD, Haigis MC, Sharpe AHCancer immunology researchPharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells. Cancer Immunol Res. 2021 02; 9(2):184-199.Cancer Immunol Res2020-12-04T00:00:002020Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells.33268780Smith SE, Chen X, Brier LM, Bumstead JR, Rensing NR, Ringel AE, Shin H, Oldenborg A, Crowley JR, Bice AR, Dikranian K, Ippolito JE, Haigis MC, Papouin T, Zhao G, Wong M, Culver JP, Bonni ANature communicationsAstrocyte deletion of a2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway. Nat Commun. 2020 12 02; 11(1):6164.Nat Commun2020-12-02T00:00:002020Astrocyte deletion of a2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway.33301708Ringel AE, Drijvers JM, Baker GJ, Catozzi A, García-Cañaveras JC, Gassaway BM, Miller BC, Juneja VR, Nguyen TH, Joshi S, Yao CH, Yoon H, Sage PT, LaFleur MW, Trombley JD, Jacobson CA, Maliga Z, Gygi SP, Sorger PK, Rabinowitz JD, Sharpe AH, Haigis MCCellObesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Cell. 2020 12 23; 183(7):1848-1866.e26.Cell2020-12-09T00:00:002020Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity.Authorship 131064922Authorship 1317132233398194Elia I, Haigis MCNature metabolismMetabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism. Nat Metab. 2021 01; 3(1):21-32.Nat Metab2021-01-04T00:00:002021Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism.Authorship 1327769733571527Wong SJ, Ringel AE, Yuan W, Paulo JA, Yoon H, Currie MA, Haigis MCThe Journal of biological chemistryDevelopment of a colorimetric a-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins. J Biol Chem. 2021 Jan-Jun; 296:100397.J Biol Chem2021-02-08T00:00:002021Development of a colorimetric a-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins.Authorship 1345167633811810Schneider JL, Rowe JH, Garcia-de-Alba C, Kim CF, Sharpe AH, Haigis MCCellThe aging lung: Physiology, disease, and immunity. Cell. 2021 04 15; 184(8):1990-2019.Cell2021-04-02T00:00:002021The aging lung: Physiology, disease, and immunity.Authorship 13475341233861966Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, Blenis JCellThe mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 2021 04 15; 184(8):2256.Cell2021-04-15T00:00:002021The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.Authorship 13551382533986176Rossmann MP, Hoi K, Chan V, Abraham BJ, Yang S, Mullahoo J, Papanastasiou M, Wang Y, Elia I, Perlin JR, Hagedorn EJ, Hetzel S, Weigert R, Vyas S, Nag PP, Sullivan LB, Warren CR, Dorjsuren B, Greig EC, Adatto I, Cowan CA, Schreiber SL, Young RA, Meissner A, Haigis MC, Hekimi S, Carr SA, Zon LIScience (New York, N.Y.)Cell-specific transcriptional control of mitochondrial metabolism by TIF1? drives erythropoiesis. Science. 2021 05 14; 372(6543):716-721.Science2021-05-14T00:00:002021Cell-specific transcriptional control of mitochondrial metabolism by TIF1? drives erythropoiesis.Authorship 1620654Authorship 1362926334091076van der Reest J, Nardini Cecchino G, Haigis MC, Kordowitzki PAgeing research reviewsMitochondria: Their relevance during oocyte ageing. Ageing Res Rev. 2021 09; 70:101378.Ageing Res Rev2021-06-04T00:00:002021Mitochondria: Their relevance during oocyte ageing.2025-06-30HAIGIS, MARCIA2021-07-01Investigating the role of PHD3 in lipid homeostasisR01DK127278Principal InvestigatorAuthorship 136976620Authorship 13712142034151238Zee BM, Poels KE, Yao CH, Kawabata KC, Wu G, Duy C, Jacobus WD, Senior E, Endress JE, Jambhekar A, Lovitch SB, Ma J, Dhall A, Harris IS, Blanco MA, Sykes DB, Licht JD, Weinstock DM, Melnick A, Haigis MC, Michor F, Shi YiScienceCombined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia. iScience. 2021 Jun 25; 24(6):102651.iScience2021-05-25T00:00:002021Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia.34216539Wagner A, Wang C, Fessler J, DeTomaso D, Avila-Pacheco J, Kaminski J, Zaghouani S, Christian E, Thakore P, Schellhaass B, Akama-Garren E, Pierce K, Singh V, Ron-Harel N, Douglas VP, Bod L, Schnell A, Puleston D, Sobel RA, Haigis M, Pearce EL, Soleimani M, Clish C, Regev A, Kuchroo VK, Yosef NCellMetabolic modeling of single Th17 cells reveals regulators of autoimmunity. Cell. 2021 08 05; 184(16):4168-4185.e21.Cell2021-07-02T00:00:002021Metabolic modeling of single Th17 cells reveals regulators of autoimmunity.Authorship 13757901634260923Zaganjor E, Yoon H, Spinelli JB, Nunn ER, Laurent G, Keskinidis P, Sivaloganathan S, Joshi S, Notarangelo G, Mulei S, Chvasta MT, Tucker SA, Kalafut K, van de Ven RAH, Clish CB, Haigis MCCell reportsSIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis. Cell Rep. 2021 07 13; 36(2):109345.Cell Rep2021-07-13T00:00:002021SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis.2026-08-31HAIGIS, MARCIA ;KIM, CARLA F.2021-09-24Progenitor cell states contributing to aging and lung cancerU01CA267827Principal InvestigatorAuthorship 1395652334547235Yoon H, Shaw JL, Haigis MC, Greka AMolecular cellLipid metabolism in sickness and in health: Emerging regulators of lipotoxicity. Mol Cell. 2021 09 16; 81(18):3708-3730.Mol Cell2021-09-16T00:00:002021Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity.Authorship 1410683334722818van Gastel N, Spinelli JB, Haigis MC, Scadden DTBio-protocolAnalysis of Leukemia Cell Metabolism through Stable Isotope Tracing in Mice. Bio Protoc. 2021 Oct 05; 11(19):e4171.Bio Protoc2021-10-05T00:00:002021Analysis of Leukemia Cell Metabolism through Stable Isotope Tracing in Mice.23663782Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, Blenis JCellThe mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 2013 May 09; 153(4):840-54.Cell2013-05-09T00:00:002013The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.35089810Spyropoulos F, Sorrentino A, van der Reest J, Yang P, Waldeck-Weiermair M, Steinhorn B, Eroglu E, Saeedi Saravi SS, Yu P, Haigis M, Christou H, Michel TAmerican journal of physiology. Heart and circulatory physiologyMetabolomic and transcriptomic signatures of chemogenetic heart failure. Am J Physiol Heart Circ Physiol. 2022 03 01; 322(3):H451-H465.Am J Physiol Heart Circ Physiol2022-01-28T00:00:002022Metabolomic and transcriptomic signatures of chemogenetic heart failure.Authorship 143077410Authorship 1432032235093211Johnson S, Haigis MC, Dougan SKCancer cellDangerous dynamic duo: Lactic acid and PD-1 blockade. Cancer Cell. 2022 02 14; 40(2):127-130.Cancer Cell2022-01-28T00:00:002022Dangerous dynamic duo: Lactic acid and PD-1 blockade.Authorship 14687261035820416Elia I, Rowe JH, Johnson S, Joshi S, Notarangelo G, Kurmi K, Weiss S, Freeman GJ, Sharpe AH, Haigis MCCell metabolismTumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells. Cell Metab. 2022 08 02; 34(8):1137-1150.e6.Cell Metab2022-07-11T00:00:002022Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells.36198703Huang M, Akerberg AA, Zhang X, Yoon H, Joshi S, Hallinan C, Nguyen C, Pu WT, Haigis MC, Burns CG, Burns CENature communicationsIntrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome. Nat Commun. 2022 10 05; 13(1):5877.Nat Commun2022-10-05T00:00:002022Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome.36173860Notarangelo G, Spinelli JB, Perez EM, Baker GJ, Kurmi K, Elia I, Stopka SA, Baquer G, Lin JR, Golby AJ, Joshi S, Baron HF, Drijvers JM, Georgiev P, Ringel AE, Zaganjor E, McBrayer SK, Sorger PK, Sharpe AH, Wucherpfennig KW, Santagata S, Agar NYR, Suvà ML, Haigis MCScience (New York, N.Y.)Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function. Science. 2022 09 30; 377(6614):1519-1529.Science2022-09-29T00:00:002022Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function.Authorship 149404123Authorship 150071024Authorship 14944886Authorship 14894699Authorship 1485997735997888Sebastiani P, Song Z, Ellis D, Tian Q, Schwaiger-Haber M, Stancliffe E, Lustgarten MS, Funk CC, Baloni P, Yao CH, Joshi S, Marron MM, Gurinovich A, Li M, Leshchyk A, Xiang Q, Andersen SL, Feitosa MF, Ukraintseva S, Soerensen M, Fiehn O, Ordovas JM, Haigis M, Monti S, Barzilai N, Milman S, Ferrucci L, Rappaport N, Patti GJ, Perls TTGeroScienceA metabolomic signature of the APOE2 allele. Geroscience. 2023 02; 45(1):415-426.Geroscience2022-08-23T00:00:002022A metabolomic signature of the APOE2 allele.35976971Kang YH, Tucker SA, Quevedo SF, Inal A, Korzenik JR, Haigis MCPloS oneMetabolic analyses reveal dysregulated NAD+ metabolism and altered mitochondrial state in ulcerative colitis. PLoS One. 2022; 17(8):e0273080.PLoS One2022-08-17T00:00:002022Metabolic analyses reveal dysregulated NAD+ metabolism and altered mitochondrial state in ulcerative colitis.36067168Stopka SA, van der Reest J, Abdelmoula WM, Ruiz DF, Joshi S, Ringel AE, Haigis MC, Agar NYRPloS oneSpatially resolved characterization of tissue metabolic compartments in fasted and high-fat diet livers. PLoS One. 2022; 17(9):e0261803.PLoS One2022-09-06T00:00:002022Spatially resolved characterization of tissue metabolic compartments in fasted and high-fat diet livers.Authorship 1510594536473467Han S, Georgiev P, Ringel AE, Sharpe AH, Haigis MCCell metabolismAge-associated remodeling of T cell immunity and metabolism. Cell Metab. 2023 01 03; 35(1):36-55.Cell Metab2022-12-05T00:00:002022Age-associated remodeling of T cell immunity and metabolism.Authorship 152878723Authorship 15292743036865221Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, Rutter J, Therrien M, Yoon H, Lai ZW, Baublis A, Subramanian R, Devkota R, Small J, Sreekanth V, Han M, Lim D, Carpenter AE, Flannick J, Finucane H, Haigis MC, Claussnitzer M, Sheu E, Stevens B, Wagner BK, Choudhary A, Shaw JL, Pablo JL, Greka AbioRxiv : the preprint server for biologyFALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. bioRxiv. 2023 Feb 20.bioRxiv2023-02-20T00:00:002023FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.36841242Weiss-Sadan T, Ge M, Hayashi M, Gohar M, Yao CH, de Groot A, Harry S, Carlin A, Fischer H, Shi L, Wei TY, Adelmann CH, Wolf K, Vornbäumen T, Dürr BR, Takahashi M, Richter M, Zhang J, Yang TY, Vijay V, Fisher DE, Hata AN, Haigis MC, Mostoslavsky R, Bardeesy N, Papagiannakopoulos T, Bar-Peled LCell metabolismNRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer. Cell Metab. 2023 03 07; 35(3):487-503.e7.Cell Metab2023-02-24T00:00:002023NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer.Authorship 1859002Authorship 1533473536960914Cable J, Rathmell JC, Pearce EL, Ho PC, Haigis MC, Mamedov MR, Wu MJ, Kaech SM, Lynch L, Febbraio MA, Bapat SP, Hong HS, Zou W, Belkaid Y, Sullivan ZA, Keller A, Wculek SK, Green DR, Postic C, Amit I, Benitah SA, Jones RG, Reina-Campos M, Torres SV, Beyaz S, Brennan D, O'Neill LAJ, Perry RJ, Brenner DAnnals of the New York Academy of SciencesImmunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report. Ann N Y Acad Sci. 2023 05; 1523(1):38-50.Ann N Y Acad Sci2023-03-24T00:00:002023Immunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report.37075753Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, Rutter JC, Therrien M, Yoon H, Lai ZW, Baublis A, Subramanian R, Devkota R, Small J, Sreekanth V, Han M, Lim D, Carpenter AE, Flannick J, Finucane H, Haigis MC, Claussnitzer M, Sheu E, Stevens B, Wagner BK, Choudhary A, Shaw JL, Pablo JL, Greka ACell metabolismFALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. Cell Metab. 2023 05 02; 35(5):887-905.e11.Cell Metab2023-04-18T00:00:002023FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.37469028Stopka SA, Ruiz D, Baquer G, Bodineau C, Hossain MA, Pellens VT, Regan MS, Pourquié O, Haigis MC, Bi WL, Coy SM, Santagata S, Agar NYR, Basu SSAnalytical chemistryChemical QuantArray: A Quantitative Tool for Mass Spectrometry Imaging. Anal Chem. 2023 08 01; 95(30):11243-11253.Anal Chem2023-07-19T00:00:002023Chemical QuantArray: A Quantitative Tool for Mass Spectrometry Imaging.Authorship 156402230Authorship 15695789Authorship 155856423Authorship 15667201037019082Weiss-Sadan T, Ge M, Hayashi M, Gohar M, Yao CH, de Groot A, Harry S, Carlin A, Fischer H, Shi L, Wei TY, Adelmann CH, Wolf K, Vornbäumen T, Dürr BR, Takahashi M, Richter M, Zhang J, Yang TY, Vijay V, Fisher DE, Hata AN, Haigis MC, Mostoslavsky R, Bardeesy N, Papagiannakopoulos T, Bar-Peled LCell metabolismNRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer. Cell Metab. 2023 Apr 04; 35(4):722.Cell Metab2023-04-04T00:00:002023NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer.37084714Yao CH, Park JS, Kurmi K, Hu SH, Notarangelo G, Crowley J, Jacobson H, Hui S, Sharpe AH, Haigis MCMolecular cellUncoupled glycerol-3-phosphate shuttle in kidney cancer reveals that cytosolic GPD is essential to support lipid synthesis. Mol Cell. 2023 04 20; 83(8):1340-1349.e7.Mol Cell2023-04-20T00:00:002023Uncoupled glycerol-3-phosphate shuttle in kidney cancer reveals that cytosolic GPD is essential to support lipid synthesis.Authorship 32361116Authorship 158831920Authorship 15890501537728660Rowe JH, Elia I, Shahid O, Gaudiano EF, Sifnugel NE, Johnson S, Reynolds AG, Fung ME, Joshi S, LaFleur MW, Park JS, Pauken KE, Rabinowitz JD, Freeman GJ, Haigis MC, Sharpe AHCancer discoveryFormate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade. Cancer Discov. 2023 12 12; 13(12):2566-2583.Cancer Discov2023-12-12T00:00:002023Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade.37716347Kurmi K, Liang D, van de Ven R, Georgiev P, Gassaway BM, Han S, Notarangelo G, Harris IS, Yao CH, Park JS, Hu SH, Peng J, Drijvers JM, Boswell S, Sokolov A, Dougan SK, Sorger PK, Gygi SP, Sharpe AH, Haigis MCCell chemical biologyMetabolic modulation of mitochondrial mass during CD4+ T cell activation. Cell Chem Biol. 2023 09 21; 30(9):1064-1075.e8.Cell Chem Biol2023-09-21T00:00:002023Metabolic modulation of mitochondrial mass during CD4+ T cell activation.Authorship 1594762437778472Georgiev P, Benamar M, Han S, Haigis MC, Sharpe AH, Chatila TAThe Journal of allergy and clinical immunologyRegulatory T cells in dominant immunologic tolerance. J Allergy Clin Immunol. 2024 01; 153(1):28-41.J Allergy Clin Immunol2023-09-29T00:00:002023Regulatory T cells in dominant immunologic tolerance.true1Research Associate in ImmunologyResearch Associate in Immunologytrue1Research Fellow in Cell BiologyResearch Fellow in Cell Biologytrue1Bert and Natalie Vallee Professor of Molecular PathologyBert and Natalie Vallee Professor of Molecular Pathologytrue1Research Fellow in Cell BiologyResearch Fellow in Cell Biologytrue1Kolokotrones University ProfessorKolokotrones University Professortrue1Professor of GeneticsProfessor of Geneticstrue1Otto Krayer Professor of Systems PharmacologyOtto Krayer Professor of Systems PharmacologyAuthorship 51398815Authorship 16229721338253001Pannek M, Alhalabi Z, Tomaselli D, Menna M, Fiorentino F, Robaa D, Weyand M, Puhlmann M, Tomassi S, Barreca F, Tafani M, Zaganjor E, Haigis MC, Sippl W, Rotili D, Mai A, Steegborn CJournal of medicinal chemistrySpecific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity. J Med Chem. 2024 Feb 08; 67(3):1843-1860.J Med Chem2024-01-22T00:00:002024Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity.true1Professor of Cell BiologyProfessor of Cell Biology2Tutor in Molecular and Cellular BiologyTutor in Molecular and Cellular Biology3Director, Gender Equity for Faculty in ScienceDirector, Gender Equity for Faculty in Sciencetrue1Professor of Systems BiologyProfessor of Systems BiologyAuthorship 2548910Authorship 2811322Authorship 64940018Authorship 6519766Authorship 64820712Authorship 6646792Authorship 66669410Authorship 6646542123283301Peserico A, Chiacchiera F, Grossi V, Matrone A, Latorre D, Simonatto M, Fusella A, Ryall JG, Finley LW, Haigis MC, Villani G, Puri PL, Sartorelli V, Simone CCellular and molecular life sciences : CMLSA novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Cell Mol Life Sci. 2013 Jun; 70(11):2015-29.Cell Mol Life Sci2013-01-03T00:00:002013A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.23499007Lee PC, Dodart JC, Aron L, Finley LW, Bronson RT, Haigis MC, Yankner BA, Harper JWMolecular cellAltered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system. Mol Cell. 2013 Apr 25; 50(2):172-84.Mol Cell2013-03-14T00:00:002013Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system.22964489Bause AS, Haigis MCExperimental gerontologySIRT3 regulation of mitochondrial oxidative stress. Exp Gerontol. 2013 Jul; 48(7):634-9.Exp Gerontol2012-08-31T00:00:002012SIRT3 regulation of mitochondrial oxidative stress.23746352Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MCMolecular cellSIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Mol Cell. 2013 Jun 06; 50(5):686-98.Mol Cell2013-06-06T00:00:002013SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.Immunology23723075Yang MH, Laurent G, Bause AS, Spang R, German N, Haigis MC, Haigis KMMolecular cancer research : MCRHDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS. Mol Cancer Res. 2013 Sep; 11(9):1072-7.Mol Cancer Res2013-05-30T00:00:002013HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS.24043310Laurent G, de Boer VC, Finley LW, Sweeney M, Lu H, Schug TT, Cen Y, Jeong SM, Li X, Sauve AA, Haigis MCMolecular and cellular biologySIRT4 represses peroxisome proliferator-activated receptor a activity to suppress hepatic fat oxidation. Mol Cell Biol. 2013 Nov; 33(22):4552-61.Mol Cell Biol2013-09-16T00:00:002013SIRT4 represses peroxisome proliferator-activated receptor a activity to suppress hepatic fat oxidation.Authorship 6755646Authorship 68170311Authorship 2170521Authorship 1812513Authorship 699545324194516Bause AS, Matsui MS, Haigis MCThe Journal of biological chemistryThe protein deacetylase SIRT3 prevents oxidative stress-induced keratinocyte differentiation. J Biol Chem. 2013 Dec 20; 288(51):36484-91.J Biol Chem2013-11-05T00:00:002013The protein deacetylase SIRT3 prevents oxidative stress-induced keratinocyte differentiation.24368766Jeong SM, Lee A, Lee J, Haigis MCThe Journal of biological chemistrySIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma. J Biol Chem. 2014 Feb 14; 289(7):4135-44.J Biol Chem2013-12-24T00:00:002013SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma.Authorship 7246644Authorship 307321324909164Jeong SM, Lee J, Finley LW, Schmidt PJ, Fleming MD, Haigis MCOncogeneSIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1. Oncogene. 2015 Apr 16; 34(16):2115-24.Oncogene2014-06-09T00:00:002014SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.Authorship 736338224924131Satterstrom FK, Haigis MCMethods in enzymologyLuciferase-based reporter to monitor the transcriptional activity of the SIRT3 promoter. Methods Enzymol. 2014; 543:141-63.Methods Enzymol2014-01-01T00:00:002014Luciferase-based reporter to monitor the transcriptional activity of the SIRT3 promoter.Authorship 7426461824982195Sinkevicius KW, Kriegel C, Bellaria KJ, Lee J, Lau AN, Leeman KT, Zhou P, Beede AM, Fillmore CM, Caswell D, Barrios J, Wong KK, Sholl LM, Schlaeger TM, Bronson RT, Chirieac LR, Winslow MM, Haigis MC, Kim CFProceedings of the National Academy of Sciences of the United States of AmericaNeurotrophin receptor TrkB promotes lung adenocarcinoma metastasis. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10299-304.Proc Natl Acad Sci U S A2014-06-30T00:00:002014Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis.25002509Janzer A, German NJ, Gonzalez-Herrera KN, Asara JM, Haigis MC, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaMetformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10574-9.Proc Natl Acad Sci U S A2014-07-07T00:00:002014Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells.Authorship 7493735Authorship 760216625241037LeBleu VS, O'Connell JT, Gonzalez Herrera KN, Wikman H, Pantel K, Haigis MC, de Carvalho FM, Damascena A, Domingos Chinen LT, Rocha RM, Asara JM, Kalluri RNature cell biologyPGC-1a mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nat Cell Biol. 2014 Oct; 16(10):992-1003, 1-15.Nat Cell Biol2014-09-21T00:00:002014PGC-1a mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.Authorship 766368625358352LeBleu VS, O'Connell JT, Herrera KN, Wikman H, Pantel K, Haigis MC, de Carvalho FM, Damascena A, Chinen LT, Rocha RM, Asara JM, Kalluri RNature cell biologyCorrigendum: PGC-1a mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nat Cell Biol. 2014 Oct 31; 16(11):1125.Nat Cell Biol2014-10-31T00:00:002014Corrigendum: PGC-1a mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.Authorship 5051451Authorship 3668771Authorship 5024743Authorship 43446213Authorship 543462Authorship 5561413Authorship 885043Authorship 925921Authorship 783772Authorship 2214262Authorship 29434515Authorship 2516144Authorship 3740814Authorship 4581311Authorship 8060923Authorship 796184625402204Ron-Harel N, Sharpe AH, Haigis MCGerontologyMitochondrial metabolism in T cell activation and senescence: a mini-review. Gerontology. 2015; 61(2):131-8.Gerontology2014-11-13T00:00:002014Mitochondrial metabolism in T cell activation and senescence: a mini-review.Authorship 48802415Authorship 808922226126285German NJ, Haigis MCCurrent biology : CBSirtuins and the Metabolic Hurdles in Cancer. Curr Biol. 2015 Jun 29; 25(13):R569-83.Curr Biol2015-06-29T00:00:002015Sirtuins and the Metabolic Hurdles in Cancer.Authorship 485321Authorship 815495426146074Sage PT, Tan CL, Freeman GJ, Haigis M, Sharpe AHCell reportsDefective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging. Cell Rep. 2015 Jul 14; 12(2):163-71.Cell Rep2015-07-02T00:00:002015Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging.Authorship 45373012Authorship 830878325898275Gonzalez Herrera KN, Lee J, Haigis MCCritical reviews in biochemistry and molecular biologyIntersections between mitochondrial sirtuin signaling and tumor cell metabolism. Crit Rev Biochem Mol Biol. 2015; 50(3):242-55.Crit Rev Biochem Mol Biol2015-04-21T00:00:002015Intersections between mitochondrial sirtuin signaling and tumor cell metabolism.Authorship 5526551Authorship 833877626109058Satterstrom FK, Swindell WR, Laurent G, Vyas S, Bulyk ML, Haigis MCAging cellNuclear respiratory factor 2 induces SIRT3 expression. Aging Cell. 2015 Oct; 14(5):818-25.Aging Cell2015-06-24T00:00:002015Nuclear respiratory factor 2 induces SIRT3 expression.Authorship 838829226420294Jeong SM, Haigis MCMolecules and cellsSirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism. Mol Cells. 2015 Sep; 38(9):750-8.Mol Cells2015-09-18T00:00:002015Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism.Authorship 51757166Fellow or Post Doc0Full Professor5Other FacultyAuthorship 8909811427411012Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, Lovitch SB, Dephoure N, Satterstrom FK, Sheffer M, Spinelli JB, Gygi S, Rabinowitz JD, Sharpe AH, Haigis MCCell metabolismMitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Cell Metab. 2016 07 12; 24(1):104-17.Cell Metab2016-07-12T00:00:002016Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation.Authorship 895485327471965Vyas S, Zaganjor E, Haigis MCCellMitochondria and Cancer. Cell. 2016 Jul 28; 166(3):555-566.Cell2016-07-28T00:00:002016Mitochondria and Cancer.Authorship 5526595Authorship 57315612020-02-29HAIGIS, MARCIA2015-03-01Control of metabolic homeostasis in diabetes by sirtuinsR01DK1032952015-08-31HAIGIS, MARCIA2009-09-15Regulation of mitochondrial metabolism by SIRT4R01AG0323752006-07-17HAIGIS, MARCIA C2003-07-18Role of Sirt4 in agingF32AG022775Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorAuthorship 9167011727635760German NJ, Yoon H, Yusuf RZ, Murphy JP, Finley LW, Laurent G, Haas W, Satterstrom FK, Guarnerio J, Zaganjor E, Santos D, Pandolfi PP, Beck AH, Gygi SP, Scadden DT, Kaelin WG, Haigis MCMolecular cellPHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2. Mol Cell. 2016 09 15; 63(6):1006-20.Mol Cell2016-09-15T00:00:002016PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.Authorship 9277651027695002Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AHNature immunologySuppression by TFR cells leads to durable and selective inhibition of B cell effector function. Nat Immunol. 2016 Dec; 17(12):1436-1446.Nat Immunol2016-10-03T00:00:002016Suppression by TFR cells leads to durable and selective inhibition of B cell effector function.Authorship 677703Authorship 9381991527881304Yang W, Nagasawa K, Münch C, Xu Y, Satterstrom K, Jeong S, Hayes SD, Jedrychowski MP, Vyas FS, Zaganjor E, Guarani V, Ringel AE, Gygi SP, Harper JW, Haigis MCCellMitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization. Cell. 2016 11 03; 167(4):985-1000.e21.Cell2016-10-27T00:00:002016Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization.Authorship 378382712560499Haigis MC, Kurten EL, Raines RTNucleic acids researchRibonuclease inhibitor as an intracellular sentry. Nucleic Acids Res. 2003 Feb 01; 31(3):1024-32.Nucleic Acids Res2003-02-01T00:00:002003Ribonuclease inhibitor as an intracellular sentry.Authorship 970594328285806van de Ven RAH, Santos D, Haigis MCTrends in molecular medicineMitochondrial Sirtuins and Molecular Mechanisms of Aging. Trends Mol Med. 2017 04; 23(4):320-331.Trends Mol Med2017-03-10T00:00:002017Mitochondrial Sirtuins and Molecular Mechanisms of Aging.17079682Haigis MC, Guarente LPGenes & developmentMammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. Genes Dev. 2006 Nov 01; 20(21):2913-21.Genes Dev2006-11-01T00:00:002006Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction.11792194Umezawa N, Gelman MA, Haigis MC, Raines RT, Gellman SHJournal of the American Chemical SocietyTranslocation of a beta-peptide across cell membranes. J Am Chem Soc. 2002 Jan 23; 124(3):368-9.J Am Chem Soc2002-01-23T00:00:002002Translocation of a beta-peptide across cell membranes.22749020Finley LW, Haigis MCTrends in molecular medicineMetabolic regulation by SIRT3: implications for tumorigenesis. Trends Mol Med. 2012 Sep; 18(9):516-23.Trends Mol Med2012-06-27T00:00:002012Metabolic regulation by SIRT3: implications for tumorigenesis.250 Longwood AveHarvard Medical SchoolCell Biology, Seeley Mudd Bldg 329250 Longwood AveBoston02115MA14724176Lin SJ, Ford E, Haigis M, Liszt G, Guarente LGenes & developmentCalorie restriction extends yeast life span by lowering the level of NADH. Genes Dev. 2004 Jan 01; 18(1):12-6.Genes Dev2004-01-01T00:00:002004Calorie restriction extends yeast life span by lowering the level of NADH.11801605Haigis MC, Kurten EL, Abel RL, Raines RTThe Journal of biological chemistryKFERQ sequence in ribonuclease A-mediated cytotoxicity. J Biol Chem. 2002 Mar 29; 277(13):11576-81.J Biol Chem2002-01-18T00:00:002002KFERQ sequence in ribonuclease A-mediated cytotoxicity.16959573Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente LCellSIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. 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