Dr. Frank A.J.L. Scheer is a Professor of Medicine at Harvard Medical School (HMS), a Senior Neuroscientist at Brigham and Women’s Hospital (BWH), and the Director of the Medical Chronobiology Program (MCP) at BWH, Boston. Dr. Scheer’s work focuses on influences of the endogenous circadian system and its disruption—such as with shift work—on cardiovascular, pulmonary, and metabolic regulation and disease states, including hypertension, asthma, obesity, and diabetes. Since 2005, Dr. Scheer has been funded continuously as Principal Investigator by the National Institutes of Health (NIH). Dr. Scheer has received numerous scientific awards, including the Young Investigator Award by the American Academy of Sleep Medicine, the Neal Miller Award by the Academy of Behavioral Medicine Research, and the Outstanding Scientific Achievement Award by the Sleep Research Society. Dr. Scheer is an Editorial Board Member of several peer-reviewed journals, including the American Journal of Cardiovascular Disease, the Neurobiology of Sleep and Circadian Rhythms, and Chronobiology International, and is an Associate Editor at Frontiers in Sleep. Trainees - Undergraduate: Taneisha Benjamin, 2005; Thomas J. Shea, 2006-2007; Anna Dowdle, 2006-2008; Grace McKay-Corkum, 2012; Isadora Bozzi, 2012-2013; Lucas Vargas, 2013; Seth Morrison, 2019; Charles Zimmerman, 2023-2024. - Masters: Mariya Kogan, 2007-2008; Kirk Krogsted, 2007-2013; Noortje Trienekens, 2011-2012; Ann-Cathrin Plennis, 2015; - PhD student: Stefan E. Knapen, 2018 (internship); Yolanda Larriba, 2019 (internship); Olga Minaeva, 2021 (internship), Phillip Alexander Keller Andersen 2022-2023 (internship); Koen Frenken 2025 (internship); Natalia Marhefkova, MD 2025-2026 (internship). - Post-doctoral: Anne-Marie Chang, PhD, 2005 - 2011; Kun Hu, PhD, 2006-2007; Mikhail Litinski, MD, 2008-2009; Christopher J. Morris, PhD, 2010-2015; Wenli Zhang, MD 2011-2012; Matthew Butler, PhD 2011-2013; David Barr, PhD 2013-2015; Jingyi Qian, PhD 2015-2020; Andrew McHill, PhD 2016-2017; Sarah Chellappa, PhD 2016-2019; Nina Vujovic, PhD, 2017-2022; Ivy Cheung Mason, PhD, 2018-2023; Raphael Knaier, PhD, 2020-2022; Angus Burns, PhD, 2024-2026; Han-Chow Koh, PhD, 2022-present; Arman Arab, PhD, 2023-present; Ioannis Lempesis, MD, PhD, 2024-present. - Junior Faculty: Lei Gao, MD 2018-2020; Jingyi Qian, PhD 2020-present; Jacqueline M. Lane, PhD 2018-2023; Fransisco Romo-Nava, MD, PhD 2020-2024; Kelly Zuromski, PhD 2020-2024; Eline H. van Roekel, PhD 2022-2025. Teaching - Course Co-Director (with Charles A. Czeisler), MCB 186, Sleep and Circadian Clocks: from Biology to Public Health, Harvard College, Cambridge, MA - General Education Course Co-Director (with Charles A. Czeisler), Gen Ed 1038, Sleep, Harvard College, Cambridge, MA
Vetter C, Dashti HS, Lane JM, Anderson SG, Schernhammer ES, Rutter MK, Saxena R, Scheer FAJL
Night Shift Work, Genetic Risk, and Type 2 Diabetes in the UK Biobank. Diabetes Care. 2018 04; 41(4):762-769.
Night Shift Work, Genetic Risk, and Type 2 Diabetes in the UK Biobank.
Scheer FAJL, Van Montfrans GA, Buijs RM.
Chronic, but not acute, nighttime melatonin administration improves sleep quality in hypertensive patients. Sleep. 2004; 27:A329.
Chronic, but not acute, nighttime melatonin administration improves sleep quality in hypertensive patients
Lopez-Minguez J, Dashti HS, Madrid-Valero JJ, Madrid JA, Saxena R, Scheer FAJL, Ordoñana JR, Garaulet M
Clinical nutrition (Edinburgh, Scotland)
Heritability of the timing of food intake. Clin Nutr. 2019 04; 38(2):767-773.
Heritability of the timing of food intake.
Reviews in endocrine & metabolic disorders
Effects of circadian disruption on the cardiometabolic system. Rev Endocr Metab Disord. 2009 Dec; 10(4):245-60.
Effects of circadian disruption on the cardiometabolic system.
The circadian pacemaker generates similar circadian rhythms in the fractal structure of heart rate in humans and rats. Cardiovasc Res. 2008 Oct 01; 80(1):62-8.
The circadian pacemaker generates similar circadian rhythms in the fractal structure of heart rate in humans and rats.
Hu K, Van Someren EJ, Shea SA, Scheer FA
Proceedings of the National Academy of Sciences of the United States of America
Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2490-4.
Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker.
Jung CM, Khalsa SB, Scheer FA, Cajochen C, Lockley SW, Czeisler CA, Wright KP
Acute effects of bright light exposure on cortisol levels. J Biol Rhythms. 2010 Jun; 25(3):208-16.
Acute effects of bright light exposure on cortisol levels.
Li P, Yu L, Lim ASP, Buchman AS, Scheer FAJL, Shea SA, Schneider JA, Bennett DA, Hu K
Alzheimer's & dementia : the journal of the Alzheimer's Association
Fractal regulation and incident Alzheimer's disease in elderly individuals. Alzheimers Dement. 2018 09; 14(9):1114-1125.
Fractal regulation and incident Alzheimer's disease in elderly individuals.
Qian J, Dalla Man C, Morris CJ, Cobelli C, Scheer FAJL
Differential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans. Diabetes Obes Metab. 2018 10; 20(10):2481-2485.
Differential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans.
Lesioning the suprachiasmatic nucleus abolishes ultradian rhythms of locomotor activity in rats. Sleep. 2007; 30:A58.
Lesioning the suprachiasmatic nucleus abolishes ultradian rhythms of locomotor activity in rats
Buijs RM, Hermes MLHJ, Dai J, Scheer FAJL, Kalsbeek A.
Ter Horst GJ (ed). The Nervous System and the Heart.
Circadian organization of the autonomic Nervous system. Ter Horst GJ (ed). The Nervous System and the Heart. 2000; 117-157.
Circadian organization of the autonomic Nervous system
Evoniuk H, Hilton MF, Scheer FAJL, Malhotra A, Shiels S, Sugarbaker R, Weiner M, Ayers RT, Massaro AF, Shea SA.
Effects of endogenous circadian rhythms, sleep and sleep deprivation on airway function in asthma explored with a constant routine protocol. Sleep. 2005; 28:A71.
Effects of endogenous circadian rhythms, sleep and sleep deprivation on airway function in asthma explored with a constant routine protocol
Kolbe I, Carrasco-Benso MP, López-Mínguez J, Luján J, Scheer FAJL, Oster H, Garaulet M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Circadian period of luciferase expression shortens with age in human mature adipocytes from obese patients. FASEB J. 2019 01; 33(1):175-180.
Circadian period of luciferase expression shortens with age in human mature adipocytes from obese patients.
Suprachiasmatic nucleus, environmental light, and metabolic state interact in the regulation of body temperature. J Sleep Res. 2006; 15(1):20.
Suprachiasmatic nucleus, environmental light, and metabolic state interact in the regulation of body temperature
Wefers J, van Moorsel D, Hansen J, Connell NJ, Havekes B, Hoeks J, van Marken Lichtenbelt WD, Duez H, Phielix E, Kalsbeek A, Boekschoten MV, Hooiveld GJ, Hesselink MKC, Kersten S, Staels B, Scheer FAJL, Schrauwen P
Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle. Proc Natl Acad Sci U S A. 2018 07 24; 115(30):7789-7794.
Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle.
Shea SA, Scheer FAJL, Evoniuk HL, Shiels SA, Malhotra A, Sugarbaker R, Ayers RT, Okruch A, Weiner M, Rinzler S, Massaro AF, Hilton MF.
Role of the endogenous circadian system in bronchoconstriction, airway inflammation and rescue medication use in asthma. Chronobiology Int. 2005.
Role of the endogenous circadian system in bronchoconstriction, airway inflammation and rescue medication use in asthma
The circadian pacemaker contributes to intrinsic scale-invariant patterns of cardiac dynamics across a wide range of time scales – Spanning 4-24 Hours. Sleep. 2007; 30:A58.
The circadian pacemaker contributes to intrinsic scale-invariant patterns of cardiac dynamics across a wide range of time scales – Spanning 4-24 Hours
Shea TJ, Hilton MF, Evoniuk H, Scheer FAJL.
Circadian effect on degree of sleep inertia present after awakening. Sleep. 2006; A67.
Circadian effect on degree of sleep inertia present after awakening
Shea SA, Hilton MF, Malhotra A, Evoniuk H, Shiels S, Sugarbaker R, Ayers RT, Weiner M, Massaro AF, Scheer FAJL.
Interaction between effects of the circadian pacemaker and behavioral sleep-wake cycle on pulmonary function in asthma. Sleep. 2005; 28:A73.
Interaction between effects of the circadian pacemaker and behavioral sleep-wake cycle on pulmonary function in asthma
Scheer FA, Hilton MF, Mantzoros CS, Shea SA
Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4453-8.
Adverse metabolic and cardiovascular consequences of circadian misalignment.
Scheer FA, Morris CJ, Garcia JI, Smales C, Kelly EE, Marks J, Malhotra A, Shea SA
Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial. Sleep. 2012 Oct 01; 35(10):1395-402.
Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial.
Scheer FA, Chan JL, Fargnoli J, Chamberland J, Arampatzi K, Shea SA, Blackburn GL, Mantzoros CS
Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions. Diabetologia. 2010 Nov; 53(11):2401-5.
Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions.
Qian J, Morris CJ, Caputo R, Garaulet M, Scheer FAJL
Ghrelin is impacted by the endogenous circadian system and by circadian misalignment in humans. Int J Obes (Lond). 2019 08; 43(8):1644-1649.
Ghrelin is impacted by the endogenous circadian system and by circadian misalignment in humans.
Scheer FAJL, Hilton MF, Benjamin T, Barb D, Evoniuk H, Mantzoros CS, Shea SA.
Desynchrony between sleep-wake cycle and circadian cycle leads to suppressed plasma leptin; potential relevance for shift workers. Sleep. 2007; 30:A61.
Desynchrony between sleep-wake cycle and circadian cycle leads to suppressed plasma leptin; potential relevance for shift workers
Scheer FAJL, Cajochen C, Turek FW, Czeisler CA.
Kryger MH, Roth T, Dement WC (ed). Principles and Practice of Sleep Medicine.
Melatonin in the regulation of sleep and circadian rhythms. Kryger MH, Roth T, Dement WC (ed). Principles and Practice of Sleep Medicine. 2005; 395-404.
Melatonin in the regulation of sleep and circadian rhythms
Existence of an endogenous circadian blood pressure rhythm in humans that peaks in the evening. Circ Res. 2011 Apr 15; 108(8):980-4.
Existence of an endogenous circadian blood pressure rhythm in humans that peaks in the evening.
The impact of the circadian timing system on cardiovascular and metabolic function. Prog Brain Res. 2012; 199:337-358.
The impact of the circadian timing system on cardiovascular and metabolic function.
Outstanding Scientific Achievement Award, Sleep Research Society
Potential use of melatonin as adjunct antihypertensive therapy. Am J Hypertens. 2005 Dec; 18(12 Pt 1):1619-20.
Potential use of melatonin as adjunct antihypertensive therapy.
Stenvers DJ, Scheer FAJL, Schrauwen P, la Fleur SE, Kalsbeek A
Circadian clocks and insulin resistance. Nat Rev Endocrinol. 2019 02; 15(2):75-89.
Circadian clocks and insulin resistance.
Evoniuk HL, Scheer FAJL, Hilton MF, Schory KE, Shea SA.
Challenges to sleep in asthma studied under baseline conditions, reduced homeostatic sleep drive, and adverse circadian phase for sleep. Sleep. 2006.
Challenges to sleep in asthma studied under baseline conditions, reduced homeostatic sleep drive, and adverse circadian phase for sleep
The endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24 hours. J Biol Rhythms. 2008 Jun; 23(3):265-73.
The endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24 hours.
Scheer FA, Hu K, Evoniuk H, Kelly EE, Malhotra A, Hilton MF, Shea SA
Impact of the human circadian system, exercise, and their interaction on cardiovascular function. Proc Natl Acad Sci U S A. 2010 Nov 23; 107(47):20541-6.
Impact of the human circadian system, exercise, and their interaction on cardiovascular function.
Scheer FAJL, Chellappa SL, Hu K, Shea SA
Impact of mental stress, the circadian system and their interaction on human cardiovascular function. Psychoneuroendocrinology. 2019 05; 103:125-129.
Impact of mental stress, the circadian system and their interaction on human cardiovascular function.
Effects of circadian misalignment on cognition in chronic shift workers. Sci Rep. 2019 01 24; 9(1):699.
Effects of circadian misalignment on cognition in chronic shift workers.
Predicting the daily pattern of asthma severity based on the relative contribution of the circadian timing system, the sleep-wake cycle and the environment. Sleep. 2007; 30:A65.
Predicting the daily pattern of asthma severity based on the relative contribution of the circadian timing system, the sleep-wake cycle and the environment
Meal timing and obesity: interactions with macronutrient intake and chronotype. Int J Obes (Lond). 2019 09; 43(9):1701-1711.
Meal timing and obesity: interactions with macronutrient intake and chronotype.
Gao L, Li P, Hu C, To T, Patxot M, Falvey B, Wong PM, Scheer FAJL, Lin C, Lo MT, Hu K
Nocturnal heart rate variability moderates the association between sleep-wake regularity and mood in young adults. Sleep. 2019 05 01; 42(5).
Nocturnal heart rate variability moderates the association between sleep-wake regularity and mood in young adults.
A healthy lifestyle - reducing T2DM risk in shift workers? Nat Rev Endocrinol. 2019 04; 15(4):194-196.
A healthy lifestyle - reducing T2DM risk in shift workers?
Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Cade BE, Haas M, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, Scheer FAJL, Schormair B, Tyrrell J, Winkelman JW, Winkelmann J, Hveem K, Zhao C, Nielsen JB, Willer CJ, Redline S, Spiegelhalder K, Kyle SD, Ray DW, Zwart JA, Brumpton B, Frayling TM, Lawlor DA, Rutter MK, Weedon MN, Saxena R
Biological and clinical insights from genetics of insomnia symptoms. Nat Genet. 2019 03; 51(3):387-393.
Biological and clinical insights from genetics of insomnia symptoms.
McHill AW, Czeisler CA, Phillips AJK, Keating L, Barger LK, Garaulet M, Scheer FAJL, Klerman EB
Caloric and Macronutrient Intake Differ with Circadian Phase and between Lean and Overweight Young Adults. Nutrients. 2019 03 11; 11(3).
Caloric and Macronutrient Intake Differ with Circadian Phase and between Lean and Overweight Young Adults.
Dashti HS, Jones SE, Wood AR, Lane JM, van Hees VT, Wang H, Rhodes JA, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Bowden J, Cade BE, Garaulet M, Kyle SD, Little MA, Loudon AS, Luik AI, Scheer FAJL, Spiegelhalder K, Tyrrell J, Gottlieb DJ, Tiemeier H, Ray DW, Purcell SM, Frayling TM, Redline S, Lawlor DA, Rutter MK, Weedon MN, Saxena R
Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. Nat Commun. 2019 03 07; 10(1):1100.
Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates.
Chang AM, Duffy JF, Buxton OM, Lane JM, Aeschbach D, Anderson C, Bjonnes AC, Cain SW, Cohen DA, Frayling TM, Gooley JJ, Jones SE, Klerman EB, Lockley SW, Munch M, Rajaratnam SMW, Rueger M, Rutter MK, Santhi N, Scheuermaier K, Van Reen E, Weedon MN, Czeisler CA, Scheer FAJL, Saxena R
Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian Period in Humans. Sci Rep. 2019 03 29; 9(1):5350.
Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian Period in Humans.
Dashti HS, Scheer FAJL, Saxena R, Garaulet M
Timing of Food Intake: Identifying Contributing Factors to Design Effective Interventions. Adv Nutr. 2019 07 01; 10(4):606-620.
Timing of Food Intake: Identifying Contributing Factors to Design Effective Interventions.
Harvard T.H. Chan School of Public Health
Associate Professor of Medicine, Part-time
Frank Baldino, Jr., Ph.D. Professor of Sleep Medicine
Peter C. Farrell Professor of Sleep Medicine
Guirette M, Dashti H, Tucker C, Vetter C, Garaulet M, Scheer F, Saxena R
How Accurately Can We Recall Food Timing? A Validity Study of a Novel Food Timing Questionnaire (P18-016-19). Curr Dev Nutr. 2019 Jun; 3(Suppl 1).
How Accurately Can We Recall Food Timing? A Validity Study of a Novel Food Timing Questionnaire (P18-016-19).
Dashti HS, Merino J, Lane JM, Song Y, Smith CE, Tanaka T, McKeown NM, Tucker C, Sun D, Bartz TM, Li-Gao R, Nisa H, Reutrakul S, Lemaitre RN, Alshehri TM, de Mutsert R, Bazzano L, Qi L, Knutson KL, Psaty BM, Mook-Kanamori DO, Perica VB, Neuhouser ML, Scheer FAJL, Rutter MK, Garaulet M, Saxena R
The American journal of clinical nutrition
Genome-wide association study of breakfast skipping links clock regulation with food timing. Am J Clin Nutr. 2019 08 01; 110(2):473-484.
Genome-wide association study of breakfast skipping links clock regulation with food timing.
Corresponding Member of the Faculty of Medicine
Williams JS, Autori PJ, Kidd SK, Piazza G, Connors MC, Czeisler CA, Scheuermaier KD, Duffy J, Klerman EB, Scheer FA, Kozak M, Driscoll SM, Goldhaber SZ
TH open : companion journal to thrombosis and haemostasis
Heparin-Induced Thrombocytopenia in Healthy Individuals with Continuous Heparin Infusion. TH Open. 2018 Jan; 2(1):e49-e53.
Heparin-Induced Thrombocytopenia in Healthy Individuals with Continuous Heparin Infusion.
Wang H, Lane JM, Jones SE, Dashti HS, Ollila HM, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojärvi K, Palviainen T, Cade BE, Sofer T, Song Y, Patel K, Anderson SG, Bechtold DA, Bowden J, Emsley R, Kyle SD, Little MA, Loudon AS, Scheer FAJL, Purcell SM, Richmond RC, Spiegelhalder K, Tyrrell J, Zhu X, Hublin C, Kaprio JA, Kristiansson K, Sulkava S, Paunio T, Hveem K, Nielsen JB, Willer CJ, Zwart JA, Strand LB, Frayling TM, Ray D, Lawlor DA, Rutter MK, Weedon MN, Redline S, Saxena R
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes. Nat Commun. 2019 08 13; 10(1):3503.
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes.
Chellappa SL, Vujovic N, Williams JS, Scheer FAJL
Trends in endocrinology and metabolism: TEM
Impact of Circadian Disruption on Cardiovascular Function and Disease. Trends Endocrinol Metab. 2019 10; 30(10):767-779.
Impact of Circadian Disruption on Cardiovascular Function and Disease.
The circadian system modulates the rate of recovery of systolic blood pressure after exercise in humans. Sleep. 2020 04 15; 43(4).
The circadian system modulates the rate of recovery of systolic blood pressure after exercise in humans.
Qian J, Morris CJ, Caputo R, Wang W, Garaulet M, Scheer FAJL
Sex differences in the circadian misalignment effects on energy regulation. Proc Natl Acad Sci U S A. 2019 11 19; 116(47):23806-23812.
Sex differences in the circadian misalignment effects on energy regulation.
Sex-dependent link between circadian misalignment and adiposity. Nat Rev Endocrinol. 2020 01; 16(1):13-15.
Sex-dependent link between circadian misalignment and adiposity.
Dashti HS, Vetter C, Lane JM, Smith MC, Wood AR, Weedon MN, Rutter MK, Garaulet M, Scheer FAJL, Saxena R
Assessment of MTNR1B Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank. Diabetes. 2020 02; 69(2):259-266.
Assessment of MTNR1B Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank.
Garaulet M, Qian J, Florez JC, Arendt J, Saxena R, Scheer FAJL
Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy. Trends Endocrinol Metab. 2020 03; 31(3):192-204.
Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy.
Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes. Diabetologia. 2020 03; 63(3):462-472.
Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes.
Sletten TL, Cappuccio FP, Davidson AJ, Van Cauter E, Rajaratnam SMW, Scheer FAJL
Health consequences of circadian disruption. Sleep. 2020 01 13; 43(1).
Health consequences of circadian disruption.
Butler MP, Thosar SS, Smales C, DeYoung PN, Wu H, Hussain MV, Morimoto M, Hu K, Scheer FAJL, Shea SA
Effects of obstructive sleep apnea on endogenous circadian rhythms assessed during relaxed wakefulness; an exploratory analysis. Chronobiol Int. 2020 06; 37(6):856-866.
Effects of obstructive sleep apnea on endogenous circadian rhythms assessed during relaxed wakefulness; an exploratory analysis.
Knapen SE, Li P, Riemersma-van der Lek RF, Verkooijen S, Boks MPM, Schoevers RA, Scheer FAJL, Hu K
Fractal biomarker of activity in patients with bipolar disorder. Psychol Med. 2021 07; 51(9):1562-1569.
Fractal biomarker of activity in patients with bipolar disorder.
Netherlands Institute for Brain Research
Netherlands Institute for Brain Research, Neuroscience
Harvard Medical School, Brigham and Women’s Hospital
Harvard Medical School, Brigham and Women’s Hospital, Sleep Medicine
Circadian Rhythms and Your Health Harvard Medical School’s Longwood Seminars
Circadian Rhythms and Your Health Harvard Medical School’s Longwood Seminars Dr. Frank Scheer - Performance Around the Clock
Circadian Rhythms and Your Health Harvard Medical School’s Longwood Seminars Dr. Frank Scheer - Performance Around the Clock The impact of circadian rhythms on diabetes (EASD 2023)
Harvard Medical School-Division of Sleep Medicine Faculty Profile
Kosmadopoulos A, Kervezee L, Boudreau P, Gonzales-Aste F, Vujovic N, Scheer FAJL, Boivin DB
Effects of Shift Work on the Eating Behavior of Police Officers on Patrol. Nutrients. 2020 Apr 04; 12(4).
Effects of Shift Work on the Eating Behavior of Police Officers on Patrol.
Xiao Q, Qian J, Evans DS, Redline S, Lane NE, Ancoli-Israel S, Scheer FAJL, Stone K
Cross-sectional and Prospective Associations of Rest-Activity Rhythms With Metabolic Markers and Type 2 Diabetes in Older Men. Diabetes Care. 2020 11; 43(11):2702-2712.
Cross-sectional and Prospective Associations of Rest-Activity Rhythms With Metabolic Markers and Type 2 Diabetes in Older Men.
Martínez-Lozano N, Tvarijonaviciute A, Ríos R, Barón I, Scheer FAJL, Garaulet M
Late Eating Is Associated with Obesity, Inflammatory Markers and Circadian-Related Disturbances in School-Aged Children. Nutrients. 2020 09 21; 12(9).
Late Eating Is Associated with Obesity, Inflammatory Markers and Circadian-Related Disturbances in School-Aged Children.
Course at Harvard College General Education 1038: Sleep
BBC News: “Sleep drug lowers blood pressure”
The American Association for the Advancement of Science (audio): “Night Shift Metabolism”
NPR News (radio): "To Maximize Weight Loss, Eat Early in The Day, Not Late"
Radio Boston: You Are When You Eat (radio)
National Public Radio (NPR): “Circadian Surprise: How Our Body Clocks Help Shape Our Waistlines”
Dashti HS, Gómez-Abellán P, Qian J, Esteban A, Morales E, Scheer FAJL, Garaulet M
Late eating is associated with cardiometabolic risk traits, obesogenic behaviors, and impaired weight loss. Am J Clin Nutr. 2021 Jan 04; 113(1):154-161.
Late eating is associated with cardiometabolic risk traits, obesogenic behaviors, and impaired weight loss.
Arredondo-Amador M, Zambrano C, Kulyté A, Luján J, Hu K, Sánchez de Medina F, Scheer FAJL, Arner P, Ryden M, Martínez-Augustin O, Garaulet M
The Journal of clinical endocrinology and metabolism
Circadian Rhythms in Hormone-sensitive Lipase in Human Adipose Tissue: Relationship to Meal Timing and Fasting Duration. J Clin Endocrinol Metab. 2020 12 01; 105(12).
Circadian Rhythms in Hormone-sensitive Lipase in Human Adipose Tissue: Relationship to Meal Timing and Fasting Duration.
Circadian misalignment increases mood vulnerability in simulated shift work. Sci Rep. 2020 10 29; 10(1):18614.
Circadian misalignment increases mood vulnerability in simulated shift work.
Qian J, Martinez-Lozano N, Tvarijonaviciute A, Rios R, Scheer FAJL, Garaulet M
Blunted rest-activity rhythms link to higher body mass index and inflammatory markers in children. Sleep. 2021 05 14; 44(5).
Blunted rest-activity rhythms link to higher body mass index and inflammatory markers in children.
Maidstone RJ, Turner J, Vetter C, Dashti HS, Saxena R, Scheer FAJL, Shea SA, Kyle SD, Lawlor DA, Loudon ASI, Blaikley JF, Rutter MK, Ray DW, Durrington HJ
Night shift work is associated with an increased risk of asthma. Thorax. 2021 01; 76(1):53-60.
Night shift work is associated with an increased risk of asthma.
McHill AW, Hilditch CJ, Fischer D, Czeisler CA, Garaulet M, Scheer FAJL, Klerman EB
Stability of the timing of food intake at daily and monthly timescales in young adults. Sci Rep. 2020 11 30; 10(1):20849.
Stability of the timing of food intake at daily and monthly timescales in young adults.
Gao L, Gaba A, Cui L, Yang HW, Saxena R, Scheer FAJL, Akeju O, Rutter MK, Lo MT, Hu K, Li P
Journal of the American Heart Association
Resting Heartbeat Complexity Predicts All-Cause and Cardiorespiratory Mortality in Middle- to Older-Aged Adults From the UK Biobank. J Am Heart Assoc. 2021 02 02; 10(3):e018483.
Resting Heartbeat Complexity Predicts All-Cause and Cardiorespiratory Mortality in Middle- to Older-Aged Adults From the UK Biobank.
Keynote at 25th anniversary Center for Sleep and Circadian Biology, Northwestern University
2017 Nobel Prize in Medicine Goes to 3 Americans for Body Clock Studies
Qian J, Walkup MP, Chen SH, Brubaker PH, Bond DS, Richey PA, Jakicic JM, Hu K, Scheer FAJL, Middelbeek RJW
Association of Objectively Measured Timing of Physical Activity Bouts With Cardiovascular Health in Type 2 Diabetes. Diabetes Care. 2021 04; 44(4):1046-1054.
Association of Objectively Measured Timing of Physical Activity Bouts With Cardiovascular Health in Type 2 Diabetes.
The journals of gerontology. Series A, Biological sciences and medical sciences
Cross-Sectional and Prospective Associations of Rest-Activity Rhythms With Circulating Inflammatory Markers in Older Men. J Gerontol A Biol Sci Med Sci. 2022 01 07; 77(1):55-65.
Cross-Sectional and Prospective Associations of Rest-Activity Rhythms With Circulating Inflammatory Markers in Older Men.
Keynote presentation from Frank A.J.L. Scheer at the 9th Annual Obesity Research Incubator Session
Q&A with Dr. Frank Scheer – AAST’s 2019 Annual Meeting Keynote Speaker
Lo EH, Albers GW, Dichgans M, Donnan G, Esposito E, Foster R, Howells DW, Huang YG, Ji X, Klerman EB, Lee S, Li W, Liebeskind DS, Lizasoain I, Mandeville ET, Moro MA, Ning M, Ray D, Sakadžic S, Saver JL, Scheer FAJL, Selim M, Tiedt S, Zhang F, Buchan AM
Circadian Biology and Stroke. Stroke. 2021 06; 52(6):2180-2190.
Li P, Zheng X, Ulsa MC, Yang HW, Scheer FAJL, Rutter MK, Hu K, Gao L
Poor sleep behavior burden and risk of COVID-19 mortality and hospitalization. Sleep. 2021 08 13; 44(8).
Poor sleep behavior burden and risk of COVID-19 mortality and hospitalization.
Food Timing to Mitigate Adverse Consequences of Night Work
Hernández-González T, González-Barrio R, Escobar C, Madrid JA, Periago MJ, Collado MC, Scheer FAJL, Garaulet M
Timing of chocolate intake affects hunger, substrate oxidation, and microbiota: A randomized controlled trial. FASEB J. 2021 07; 35(7):e21649.
Timing of chocolate intake affects hunger, substrate oxidation, and microbiota: A randomized controlled trial.
Knaier R, Qian J, Roth R, Infanger D, Notter T, Wang W, Cajochen C, Scheer FAJL
Medicine and science in sports and exercise
Diurnal Variation in Maximum Endurance and Maximum Strength Performance: A Systematic Review and Meta-analysis. Med Sci Sports Exerc. 2022 01 01; 54(1):169-180.
Diurnal Variation in Maximum Endurance and Maximum Strength Performance: A Systematic Review and Meta-analysis.
Scheer FAJL, Hilton MF, Evoniuk HL, Shiels SA, Malhotra A, Sugarbaker R, Ayers RT, Israel E, Massaro AF, Shea SA
The endogenous circadian system worsens asthma at night independent of sleep and other daily behavioral or environmental cycles. Proc Natl Acad Sci U S A. 2021 09 14; 118(37).
The endogenous circadian system worsens asthma at night independent of sleep and other daily behavioral or environmental cycles.
Ulsa MC, Xi Z, Li P, Gaba A, Wong PM, Saxena R, Scheer FAJL, Rutter M, Akeju O, Hu K, Gao L
Association of Poor Sleep Burden in Middle Age and Older Adults With Risk for Delirium During Hospitalization. J Gerontol A Biol Sci Med Sci. 2022 03 03; 77(3):507-516.
Association of Poor Sleep Burden in Middle Age and Older Adults With Risk for Delirium During Hospitalization.
Yuan RK, Zitting KM, Duffy JF, Vujovic N, Wang W, Quan SF, Klerman EB, Scheer FAJL, Buxton OM, Williams JS, Czeisler CA
Chronic Sleep Restriction While Minimizing Circadian Disruption Does Not Adversely Affect Glucose Tolerance. Front Physiol. 2021; 12:764737.
Chronic Sleep Restriction While Minimizing Circadian Disruption Does Not Adversely Affect Glucose Tolerance.
Chellappa SL, Engen PA, Naqib A, Qian J, Vujovic N, Rahman N, Green SJ, Garaulet M, Keshavarzian A, Scheer FAJL
Proof-of-principle demonstration of endogenous circadian system and circadian misalignment effects on human oral microbiota. FASEB J. 2022 01; 36(1):e22043.
Proof-of-principle demonstration of endogenous circadian system and circadian misalignment effects on human oral microbiota.
Chellappa SL, Qian J, Vujovic N, Morris CJ, Nedeltcheva A, Nguyen H, Rahman N, Heng SW, Kelly L, Kerlin-Monteiro K, Srivastav S, Wang W, Aeschbach D, Czeisler CA, Shea SA, Adler GK, Garaulet M, Scheer FAJL
Daytime eating prevents internal circadian misalignment and glucose intolerance in night work. Sci Adv. 2021 Dec 03; 7(49):eabg9910.
Daytime eating prevents internal circadian misalignment and glucose intolerance in night work.
Delisle BP, George AL, Nerbonne JM, Bass JT, Ripplinger CM, Jain MK, Hermanstyne TO, Young ME, Kannankeril PJ, Duffy JF, Goldhaber JI, Hall MH, Somers VK, Smolensky MH, Garnett CE, Anafi RC, Scheer FAJL, Shivkumar K, Shea SA, Balijepalli RC
Circulation. Arrhythmia and electrophysiology
Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 2: Population and Clinical Considerations. Circ Arrhythm Electrophysiol. 2021 11; 14(11):e010190.
Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 2: Population and Clinical Considerations.
Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 1: Basic and Translational Aspects. Circ Arrhythm Electrophysiol. 2021 11; 14(11):e010181.
Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 1: Basic and Translational Aspects.
Gao L, Gaba A, Li P, Saxena R, Scheer FAJL, Akeju O, Rutter MK, Hu K
Heart rate response and recovery during exercise predict future delirium risk-A prospective cohort study in middle- to older-aged adults. J Sport Health Sci. 2023 05; 12(3):312-323.
Heart rate response and recovery during exercise predict future delirium risk-A prospective cohort study in middle- to older-aged adults.
Garaulet M, Lopez-Minguez J, Dashti HS, Vetter C, Hernández-Martínez AM, Pérez-Ayala M, Baraza JC, Wang W, Florez JC, Scheer FAJL, Saxena R
Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial. Diabetes Care. 2022 03 01; 45(3):512-519.
Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial.
Wired: "Why Does Asthma Get Worse at Night?"
New Scientist: "Night-shift workers who eat only in the day may cut diabetes risk Read more: https"
Science Daily: "How the timing of dinner and genetics affect individuals’ blood sugar control"
Qian J, Morris CJ, Phillips AJK, Li P, Rahman SA, Wang W, Hu K, Arendt J, Czeisler CA, Scheer FAJL
Unanticipated daytime melatonin secretion on a simulated night shift schedule generates a distinctive 24-h melatonin rhythm with antiphasic daytime and nighttime peaks. J Pineal Res. 2022 Apr; 72(3):e12791.
Unanticipated daytime melatonin secretion on a simulated night shift schedule generates a distinctive 24-h melatonin rhythm with antiphasic daytime and nighttime peaks.
Zitting KM, Vetrivelan R, Yuan RK, Vujovic N, Wang W, Bandaru SS, Quan SF, Klerman EB, Scheer FAJL, Buxton OM, Williams JS, Duffy JF, Saper CB, Czeisler CA
Chronic circadian disruption on a high-fat diet impairs glucose tolerance. Metabolism. 2022 05; 130:155158.
Chronic circadian disruption on a high-fat diet impairs glucose tolerance.
Gioia SC, Guirette M, Chen A, Tucker C, Gray BE, Vetter C, Garaulet M, Scheer FAJL, Saxena R, Dashti HS
How Accurately Can We Recall the Timing of Food Intake? A Comparison of Food Times from Recall-Based Survey Questions and Daily Food Records. Curr Dev Nutr. 2022 Feb; 6(2):nzac002.
How Accurately Can We Recall the Timing of Food Intake? A Comparison of Food Times from Recall-Based Survey Questions and Daily Food Records.
Grant LK, Coborn JE, Cohn A, Nathan MD, Scheer FAJL, Klerman EB, Kaiser UB, Harder J, Abramson M, Elguenaoui E, Russell JA, Wiley A, Rahman SA, Joffe H
Sleep Fragmentation and Estradiol Suppression Decrease Fat Oxidation in Premenopausal Women. J Clin Endocrinol Metab. 2022 07 14; 107(8):e3167-e3176.
Sleep Fragmentation and Estradiol Suppression Decrease Fat Oxidation in Premenopausal Women.
Nature: "Can resetting the body clock help with depression?"
Lane JM, Qian J, Mignot E, Redline S, Scheer FAJL, Saxena R
Genetics of circadian rhythms and sleep in human health and disease. Nat Rev Genet. 2023 01; 24(1):4-20.
Genetics of circadian rhythms and sleep in human health and disease.
McHill AW, Brown LS, Phillips AJK, Barger LK, Garaulet M, Scheer FAJL, Klerman EB
Later energy intake relative to mathematically modeled circadian time is associated with higher percentage body fat. Obesity (Silver Spring). 2023 02; 31 Suppl 1:50-56.
Later energy intake relative to mathematically modeled circadian time is associated with higher percentage body fat.
Qian J, Vujovic N, Nguyen H, Rahman N, Heng SW, Amira S, Scheer FAJL, Chellappa SL
Daytime eating prevents mood vulnerability in night work. Proc Natl Acad Sci U S A. 2022 09 20; 119(38):e2206348119.
Daytime eating prevents mood vulnerability in night work.
Romo-Nava F, Guerdjikova AI, Mori NN, Scheer FAJL, Burgess HJ, McNamara RK, Welge JA, Grilo CM, McElroy SL
A matter of time: A systematic scoping review on a potential role of the circadian system in binge eating behavior. Front Nutr. 2022; 9:978412.
A matter of time: A systematic scoping review on a potential role of the circadian system in binge eating behavior.
Lee BY, Ordovás JM, Parks EJ, Anderson CAM, Barabási AL, Clinton SK, de la Haye K, Duffy VB, Franks PW, Ginexi EM, Hammond KJ, Hanlon EC, Hittle M, Ho E, Horn AL, Isaacson RS, Mabry PL, Malone S, Martin CK, Mattei J, Meydani SN, Nelson LM, Neuhouser ML, Parent B, Pronk NP, Roche HM, Saria S, Scheer FAJL, Segal E, Sevick MA, Spector TD, Van Horn L, Varady KA, Voruganti VS, Martinez MF
Research gaps and opportunities in precision nutrition: an NIH workshop report. Am J Clin Nutr. 2022 12 19; 116(6):1877-1900.
Research gaps and opportunities in precision nutrition: an NIH workshop report.
Vujovic N, Piron MJ, Qian J, Chellappa SL, Nedeltcheva A, Barr D, Heng SW, Kerlin K, Srivastav S, Wang W, Shoji B, Garaulet M, Brady MJ, Scheer FAJL
Late isocaloric eating increases hunger, decreases energy expenditure, and modifies metabolic pathways in adults with overweight and obesity. Cell Metab. 2022 10 04; 34(10):1486-1498.e7.
Late isocaloric eating increases hunger, decreases energy expenditure, and modifies metabolic pathways in adults with overweight and obesity.
Gao C, Li P, Morris CJ, Zheng X, Ulsa MC, Gao L, Scheer FAJL, Hu K
Actigraphy-Based Sleep Detection: Validation with Polysomnography and Comparison of Performance for Nighttime and Daytime Sleep During Simulated Shift Work. Nat Sci Sleep. 2022; 14:1801-1816.
Actigraphy-Based Sleep Detection: Validation with Polysomnography and Comparison of Performance for Nighttime and Daytime Sleep During Simulated Shift Work.
Wang W, Yuan RK, Mitchell JF, Zitting KM, St Hilaire MA, Wyatt JK, Scheer FAJL, Wright KP, Brown EN, Ronda JM, Klerman EB, Duffy JF, Dijk DJ, Czeisler CA
Desynchronizing the sleep---wake cycle from circadian timing to assess their separate contributions to physiology and behaviour and to estimate intrinsic circadian period. Nat Protoc. 2023 02; 18(2):579-603.
Desynchronizing the sleep---wake cycle from circadian timing to assess their separate contributions to physiology and behaviour and to estimate intrinsic circadian period.
Klerman EB, Brager A, Carskadon MA, Depner CM, Foster R, Goel N, Harrington M, Holloway PM, Knauert MP, LeBourgeois MK, Lipton J, Merrow M, Montagnese S, Ning M, Ray D, Scheer FAJL, Shea SA, Skene DJ, Spies C, Staels B, St-Onge MP, Tiedt S, Zee PC, Burgess HJ
Keeping an eye on circadian time in clinical research and medicine. Clin Transl Med. 2022 12; 12(12):e1131.
Keeping an eye on circadian time in clinical research and medicine.
Gao L, Li P, Gaykova N, Zheng X, Gao C, Lane JM, Saxena R, Scheer FAJL, Rutter MK, Akeju O, Hu K
Circadian Rest-Activity Rhythms, Delirium Risk, and Progression to Dementia. Ann Neurol. 2023 06; 93(6):1145-1157.
Circadian Rest-Activity Rhythms, Delirium Risk, and Progression to Dementia.
Chen RW, Ulsa MC, Li P, Gao C, Zheng X, Xu J, Luo Y, Shen S, Lane J, Scheer FAJL, Hu K, Gao L
Sleep behavior traits and associations with opioid-related adverse events: a cohort study. Sleep. 2023 09 08; 46(9).
Sleep behavior traits and associations with opioid-related adverse events: a cohort study.
Pillars of Excellence Award, Mass General Brigham
CTV News (video): “Eating Later Could Make You Hungrier”
Fortune: “When you eat matters: Late-night eating makes you hungry and burns fewer calories, new s
247Muscle Podcast: “E13 - Part 1: Health risks of shift work & how to minimize them” (Podcast)
247Muscle Podcast: “E14 - Part 2: Health risks of shift work & how to minimize them” (Podcast)
The Washington Post: “It’s not just what you eat, but the time of day you eat it”
Cohn AY, Grant LK, Nathan MD, Wiley A, Abramson M, Harder JA, Crawford S, Klerman EB, Scheer FAJL, Kaiser UB, Rahman SA, Joffe H
Effects of Sleep Fragmentation and Estradiol Decline on Cortisol in a Human Experimental Model of Menopause. J Clin Endocrinol Metab. 2023 10 18; 108(11):e1347-e1357.
Effects of Sleep Fragmentation and Estradiol Decline on Cortisol in a Human Experimental Model of Menopause.
Qian J, Xiao Q, Walkup MP, Coday M, Erickson ML, Unick J, Jakicic JM, Hu K, Scheer FAJL, Middelbeek RJW
Association of Timing of Moderate-to-Vigorous Physical Activity With Changes in Glycemic Control Over 4 Years in Adults With Type 2 Diabetes From the Look AHEAD Trial. Diabetes Care. 2023 07 01; 46(7):1417-1424.
Association of Timing of Moderate-to-Vigorous Physical Activity With Changes in Glycemic Control Over 4 Years in Adults With Type 2 Diabetes From the Look AHEAD Trial.
Bruggisser F, Knaier R, Roth R, Wang W, Qian J, Scheer FAJL
Best Time of Day for Strength and Endurance Training to Improve Health and Performance? A Systematic Review with Meta-analysis. Sports Med Open. 2023 May 19; 9(1):34.
Best Time of Day for Strength and Endurance Training to Improve Health and Performance? A Systematic Review with Meta-analysis.
Mrosovsky Keynote Lecture Award, Canadian Society for Chronobiology
Qian J, Morris CJ, Caputo R, Scheer FAJL
Circadian misalignment increases 24-hour acylated ghrelin in chronic shift workers: a randomized crossover trial. Obesity (Silver Spring). 2023 09; 31(9):2235-2239.
Circadian misalignment increases 24-hour acylated ghrelin in chronic shift workers: a randomized crossover trial.
Zambrano C, Kulyté A, Luján J, Rivero-Gutierrez B, Sánchez de Medina F, Martínez-Augustin O, Ryden M, Scheer FAJL, Garaulet M
Habitual nappers and non-nappers differ in circadian rhythms of LIPE expression in abdominal adipose tissue explants. Front Endocrinol (Lausanne). 2023; 14:1166961.
Habitual nappers and non-nappers differ in circadian rhythms of LIPE expression in abdominal adipose tissue explants.
Garaulet M, Vizmanos B, Muela T, Betancourt-Núñez A, Bonmatí-Carrión MÁ, Vetter C, Dashti HS, Saxena R, Scheer FAJL
Evening types as determined by subjective and objective measures are more emotional eaters. Obesity (Silver Spring). 2023 05; 31(5):1192-1203.
Evening types as determined by subjective and objective measures are more emotional eaters.
Gao L, Zheng X, Baker SN, Li P, Scheer FAJL, Nogueira RC, Hu K
medRxiv : the preprint server for health sciences
Associations of rest-activity rhythm disturbances with stroke risk and post-stroke adverse outcomes. medRxiv. 2023 May 16.
Associations of rest-activity rhythm disturbances with stroke risk and post-stroke adverse outcomes.
Vizmanos B, Cascales AI, Rodríguez-Martín M, Salmerón D, Morales E, Aragón-Alonso A, Scheer FAJL, Garaulet M
Lifestyle mediators of associations among siestas, obesity, and metabolic health. Obesity (Silver Spring). 2023 05; 31(5):1227-1239.
Lifestyle mediators of associations among siestas, obesity, and metabolic health.
Vlasac IM, Bormes GW, Do E, Benkhoukha SS, Diallo N, Fryou NL, Gioia S, Akeju O, Joseph C, Kuan A, Lapan J, Oluwadara D, Team TP, Rahman SA, Saxena R, Scheer FAJL, Westover MB, Winkelman JW, Woodson F, Lane JM
A Novel Home-Based Study of Circadian Rhythms: Design, Rationale, and Methods for the Circadia Study. Sleep. 2023 Aug 09.
A Novel Home-Based Study of Circadian Rhythms: Design, Rationale, and Methods for the Circadia Study.
Arab A, Karimi E, Garaulet M, Scheer FAJL
Social jetlag and dietary intake: A systematic review. Sleep Med Rev. 2023 10; 71:101820.
Social jetlag and dietary intake: A systematic review.
Larriba Y, Mason IC, Saxena R, Scheer FAJL, Rueda C
CIRCUST: A novel methodology for temporal order reconstruction of molecular rhythms; validation and application towards a daily rhythm gene expression atlas in humans. PLoS Comput Biol. 2023 09; 19(9):e1011510.
CIRCUST: A novel methodology for temporal order reconstruction of molecular rhythms; validation and application towards a daily rhythm gene expression atlas in humans.
Endogenous circadian rhythms in mood and well-being. Sleep Health. 2024 02; 10(1S):S149-S153.
Endogenous circadian rhythms in mood and well-being.
Wallace DA, Qiu X, Schwartz J, Huang T, Scheer FAJL, Redline S, Sofer T
Light exposure during sleep is associated with irregular sleep timing: the Multi-Ethnic Study of Atherosclerosis (MESA). medRxiv. 2023 Oct 12.
Light exposure during sleep is associated with irregular sleep timing: the Multi-Ethnic Study of Atherosclerosis (MESA).
Heller HC, Herzog E, Brager A, Poe G, Allada R, Scheer F, Carskadon M, de la Iglesia HO, Jang R, Montero A, Wright K, Mouraine P, Walker MP, Goel N, Hogenesch J, Van Gelder RN, Kriegsfeld L, Mah C, Colwell C, Zeitzer J, Grandner M, Jackson CL, Roxanne Prichard J, Kay SA, Paul K
The Negative Effects of Travel on Student Athletes Through Sleep and Circadian Disruption. J Biol Rhythms. 2024 02; 39(1):5-19.
The Negative Effects of Travel on Student Athletes Through Sleep and Circadian Disruption.
Obesity reviews : an official journal of the International Association for the Study of Obesity
Social jetlag and obesity: A systematic review and meta-analysis. Obes Rev. 2024 03; 25(3):e13664.
Social jetlag and obesity: A systematic review and meta-analysis.
Environmental pollution (Barking, Essex : 1987)
Light exposure during sleep is bidirectionally associated with irregular sleep timing: The multi-ethnic study of atherosclerosis (MESA). Environ Pollut. 2024 Mar 01; 344:123258.
Light exposure during sleep is bidirectionally associated with irregular sleep timing: The multi-ethnic study of atherosclerosis (MESA).
Effect of high fat diet on the circadian system and on circadian rhythms in energy intake and expenditure
Effect of temporal distribution of macronutrient intake on metabolism
The major goals of this project are to determine whether macronutrient intake will alter the circadian system and thereby rhythms of energy balance regulation in human.
The major goals of this project are to determine whether the temporal distribution of macronutrient intake will affect metabolism in humans.
Impact of polygenic score for BMI on weight loss effectiveness and genome-wide association analysis. Int J Obes (Lond). 2024 05; 48(5):694-701.
Impact of polygenic score for BMI on weight loss effectiveness and genome-wide association analysis.
Klerman EB, Wright KP, Duffy JF, Scheer FAJL, Chang AM, Czeisler CA, Rajaratnam SM
A perspective on the Festschrift of Charles A. Czeisler, PhD MD. Sleep Health. 2024 Feb; 10(1S):S4-S10.
A perspective on the Festschrift of Charles A. Czeisler, PhD MD.
Meyer N, Lok R, Schmidt C, Kyle SD, McClung CA, Cajochen C, Scheer FAJL, Jones MW, Chellappa SL
The sleep-circadian interface: A window into mental disorders. Proc Natl Acad Sci U S A. 2024 Feb 27; 121(9):e2214756121.
The sleep-circadian interface: A window into mental disorders.
Publisher Correction: Impact of polygenic score for BMI on weight loss effectiveness and genome-wide association analysis. Int J Obes (Lond). 2024 May; 48(5):746.
Publisher Correction: Impact of polygenic score for BMI on weight loss effectiveness and genome-wide association analysis.
Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure. Circ Res. 2024 03 15; 134(6):810-832.
Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure.
Dietary patterns and insomnia symptoms: A systematic review and meta-analysis. Sleep Med Rev. 2024 06; 75:101936.
Dietary patterns and insomnia symptoms: A systematic review and meta-analysis.
Chong MY, Frenken KG, Eussen SJPM, Koster A, Pot GK, Breukink SO, Janssen-Heijnen M, Keulen ETP, Bijnens W, Buffart LM, Meijer K, Scheer FAJL, Steindorf K, de Vos-Geelen J, Weijenberg MP, van Roekel EH, Bours MJL
The international journal of behavioral nutrition and physical activity
Longitudinal associations of diurnal rest-activity rhythms with fatigue, insomnia, and health-related quality of life in survivors of colorectal cancer up to 5 years post-treatment. Int J Behav Nutr Phys Act. 2024 May 02; 21(1):51.
Longitudinal associations of diurnal rest-activity rhythms with fatigue, insomnia, and health-related quality of life in survivors of colorectal cancer up to 5 years post-treatment.
Zambrano C, Garitaonaindia MT, Salmerón D, Pérez-Sanz F, Tchio C, Picinato MC, de Medina FS, Luján J, Scheer FAJL, Saxena R, Martínez-Augustin O, Garaulet M
Melatonin decreases human adipose tissue insulin sensitivity. J Pineal Res. 2024 Aug; 76(5):e12965.
Melatonin decreases human adipose tissue insulin sensitivity.
Grant LK, Gonsalvez I, Cohn AY, Nathan MD, Harder JA, Klerman EB, Scheer FAJL, Kaiser UB, Crawford S, Luo T, Wiley A, Rahman SA, Joffe H
The effect of experimentally induced sleep fragmentation and estradiol suppression on neurobehavioral performance and subjective sleepiness in premenopausal women. Sleep. 2024 08 14; 47(8).
The effect of experimentally induced sleep fragmentation and estradiol suppression on neurobehavioral performance and subjective sleepiness in premenopausal women.
Rodríguez-Martín M, Pérez-Sanz F, Zambrano C, Luján J, Ryden M, Scheer FAJL, Garaulet M
Circadian transcriptome oscillations in human adipose tissue depend on napping status and link to metabolic and inflammatory pathways. Sleep. 2024 11 08; 47(11).
Circadian transcriptome oscillations in human adipose tissue depend on napping status and link to metabolic and inflammatory pathways.
Zambrano C, González-Alvarado E, Salmerón D, Ruiz-Ojeda FJ, Luján J, Scheer FAJL, Garaulet M
Time-restricted eating affects human adipose tissue fat mobilization. Obesity (Silver Spring). 2024 Sep; 32(9):1680-1688.
Time-restricted eating affects human adipose tissue fat mobilization.
Associations of Rest-Activity Rhythm Disturbances With Stroke Risk and Poststroke Adverse Outcomes. J Am Heart Assoc. 2024 Sep 17; 13(18):e032086.
Associations of Rest-Activity Rhythm Disturbances With Stroke Risk and Poststroke Adverse Outcomes.
Murray JM, Stone JE, Abbott SM, Bjorvatn B, Burgess HJ, Cajochen C, Dekker JJ, Duffy JF, Epstein LJ, Garbazza C, Harsh J, Klerman EB, Lane JM, Lockley SW, Pavlova MK, Quan SF, Reid KJ, Scheer FAJL, Sletten TL, Wright KP, Zee PC, Phillips AJK, Czeisler CA, Rajaratnam SMW
A Protocol to Determine Circadian Phase by At-Home Salivary Dim Light Melatonin Onset Assessment. J Pineal Res. 2024 Aug; 76(5):e12994.
A Protocol to Determine Circadian Phase by At-Home Salivary Dim Light Melatonin Onset Assessment.
Chang AM, Scheer FA, Czeisler CA, Aeschbach D
Direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans depend on prior light history. Sleep. 2013 Aug 01; 36(8):1239-46.
Direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans depend on prior light history.
Wu YH, Ursinus J, Zhou JN, Scheer FA, Ai-Min B, Jockers R, van Heerikhuize J, Swaab DF
Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression. J Affect Disord. 2013 Jun; 148(2-3):357-67.
Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression.
Hu K, Harper DG, Shea SA, Stopa EG, Scheer FA
Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia. Sci Rep. 2013; 3:2229.
Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia.
Garaulet M, Gómez-Abellán P, Alburquerque-Béjar JJ, Lee YC, Ordovás JM, Scheer FA
Timing of food intake predicts weight loss effectiveness. Int J Obes (Lond). 2013 Apr; 37(4):604-11.
Timing of food intake predicts weight loss effectiveness.
Morris CJ, Hastings JA, Boyd K, Krainski F, Perhonen MA, Scheer FA, Levine BD
Day/night variability in blood pressure: influence of posture and physical activity. Am J Hypertens. 2013 Jun; 26(6):822-8.
Day/night variability in blood pressure: influence of posture and physical activity.
The internal circadian clock increases hunger and appetite in the evening independent of food intake and other behaviors. Obesity (Silver Spring). 2013 Mar; 21(3):421-3.
The internal circadian clock increases hunger and appetite in the evening independent of food intake and other behaviors.
Minaeva O, Riese H, Booij SH, Lamers F, Giltay EJ, Scheer FAJL, Hu K
Fractal motor activity during wakefulness and sleep: a window into depression recency and symptom recurrence. Psychol Med. 2024 Nov; 54(15):4429-4437.
Fractal motor activity during wakefulness and sleep: a window into depression recency and symptom recurrence.
Rodríguez-Martín M, Salmerón D, Dashti HS, Isabel Cascales A, Aragón-Alonso A, Scheer FAJL, Saxena R, Garaulet M
Siesta behavior and genetics interact to influence obesity risk. Obesity (Silver Spring). 2025 Jan; 33(1):164-176.
Siesta behavior and genetics interact to influence obesity risk.
Pittman-Polletta BR, Scheer FA, Butler MP, Shea SA, Hu K
Biological reviews of the Cambridge Philosophical Society
The role of the circadian system in fractal neurophysiological control. Biol Rev Camb Philos Soc. 2013 Nov; 88(4):873-94.
The role of the circadian system in fractal neurophysiological control.
Arab A, Lempesis IG, Garaulet M, Scheer FAJL
Sleep and the Mediterranean diet: A systematic review and meta-analysis. Sleep Med Rev. 2025 Apr; 80:102071.
Sleep and the Mediterranean diet: A systematic review and meta-analysis.
Lane JM, Tare A, Cade BE, Chen TH, Punjabi NM, Gottlieb DJ, Scheer FA, Redline S, Saxena R
Common variants in CLOCK are not associated with measures of sleep duration in people of european ancestry from the sleep heart health study. Biol Psychiatry. 2013 Dec 15; 74(12):e33-5.
Common variants in CLOCK are not associated with measures of sleep duration in people of european ancestry from the sleep heart health study.
Chellappa SL, Gao L, Qian J, Vujovic N, Li P, Hu K, Scheer FAJL
Daytime eating during simulated night work mitigates changes in cardiovascular risk factors: secondary analyses of a randomized controlled trial. Nat Commun. 2025 Apr 08; 16(1):3186.
Daytime eating during simulated night work mitigates changes in cardiovascular risk factors: secondary analyses of a randomized controlled trial.
Wallace DA, Evenson KR, Isasi CR, Patel SR, Sotres-Alvarez D, Zee PC, Redline S, Scheer FAJL, Sofer T
Characteristics of objectively-measured naturalistic light exposure patterns in U.S. adults: A cross-sectional analysis of two cohorts. Sci Total Environ. 2025 Mar 15; 969:178839.
Characteristics of objectively-measured naturalistic light exposure patterns in U.S. adults: A cross-sectional analysis of two cohorts.
Barker DH, Carskadon MA, Gredvig-Ardito C, Hart CN, Raynor HA, Scheer FAJL
Independent effects of the human circadian system and sleep/eating cycles on caloric intake in adolescents vary by weight status. Proc Natl Acad Sci U S A. 2025 Feb 25; 122(8):e2407907122.
Independent effects of the human circadian system and sleep/eating cycles on caloric intake in adolescents vary by weight status.
Dashti HS, Jansen EC, Zuraikat FM, Dixit S, Brown M, Laposky A, Broussard JL, Butler MP, Creasy SA, Crispim CA, Depner CM, Esser KA, Garaulet M, Hanlon EC, Makarem N, Manoogian ENC, Peterson CM, Scheer FAJL, Wright KP, Goff DC, Pratt CA, Gamble KL, St-Onge MP
Advancing Chrononutrition for Cardiometabolic Health: A 2023 National Heart, Lung, and Blood Institute Workshop Report. J Am Heart Assoc. 2025 May 06; 14(9):e039373.
Advancing Chrononutrition for Cardiometabolic Health: A 2023 National Heart, Lung, and Blood Institute Workshop Report.
Performance Around the Clock - Dr. Frank Scheer (video)
EASD 2023 - Charna Dibner and Frank Scheer discussing the impact of circadian rhythms on diabetes (video)
The New York Times: “Is it bad to eat late at night?”
Mass General Brigham: “What’s the Impact of Sleep on Health?”
Brigham Clinical & Research News: “Look Who’s Talking”
Food, We Need To Talk: “Why Am I Always Tired with Harvard Sleep Professor Frank Scheer” (Podcast)
The New York Times: “Should Dinner Be the Smallest Meal of the Day?”
NewsWeek: Teens' Late-Night Snacking Linked to Biological Clock
MGB Newsroom: "Eating Only During the Daytime Could Protect People from the Heart Risks of Shift Work"
Yang HW, De la Peña-Armada R, Sun H, Peng YQ, Lo MT, Scheer FAJL, Hu K, Garaulet M
Uncovering key factors in weight loss effectiveness through machine learning. Int J Obes (Lond). 2025 Jun; 49(6):1189-1199.
Uncovering key factors in weight loss effectiveness through machine learning.
Tare A, Lane JM, Cade BE, Grant SF, Chen TH, Punjabi NM, Lauderdale DS, Zee PC, Gharib SA, Gottlieb DJ, Scheer FA, Redline S, Saxena R
Sleep duration does not mediate or modify association of common genetic variants with type 2 diabetes. Diabetologia. 2014 Feb; 57(2):339-46.
Sleep duration does not mediate or modify association of common genetic variants with type 2 diabetes.
Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle. Blood. 2014 Jan 23; 123(4):590-3.
Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle.
Buijs FN, Cazarez F, Basualdo MC, Scheer FA, Perusquía M, Centurion D, Buijs RM
The suprachiasmatic nucleus is part of a neural feedback circuit adapting blood pressure response. Neuroscience. 2014 Apr 25; 266:197-207.
The suprachiasmatic nucleus is part of a neural feedback circuit adapting blood pressure response.
Illuminating the influence of natural daylight on human metabolism. Cell Metab. 2026 Jan 06; 38(1):7-8.
Illuminating the influence of natural daylight on human metabolism.
Hsieh WH, Escobar C, Yugay T, Lo MT, Pittman-Polletta B, Salgado-Delgado R, Scheer FA, Shea SA, Buijs RM, Hu K
Simulated shift work in rats perturbs multiscale regulation of locomotor activity. J R Soc Interface. 2014 Jul 06; 11(96).
Simulated shift work in rats perturbs multiscale regulation of locomotor activity.
Frenken KG, Buffart LM, Bours M, Breukink SO, Janssen-Heijnen M, Konsten J, Keulen ETP, Siffels A, Koster A, Meijer K, Scheer FAJL, Steindorf K, Geelen JV, Weijenberg MP, Roekel EHV
Cancer control : journal of the Moffitt Cancer Center
Longitudinal Associations of Sedentary Behavior and Physical Activity With Sleep Duration and Quality in Individuals Living With and Beyond Colorectal Cancer. Cancer Control. 2025 Jan-Dec; 32:10732748251397676.
Longitudinal Associations of Sedentary Behavior and Physical Activity With Sleep Duration and Quality in Individuals Living With and Beyond Colorectal Cancer.
Frenken KG, Chong MY, Breukink SO, Janssen-Heijnen M, Keulen ETP, Konsten J, Bijnens W, Buffart LM, Meijer K, Scheer FAJL, Steindorf K, de Vos-Geelen J, Weijenberg MP, Bours MJL, van Roekel EH
Longitudinal Associations of Sedentary Behavior and Physical Activity With Diurnal Rest-Activity Rhythms in Survivors of Colorectal Cancer Up to 5 Years Post-Treatment. J Biol Rhythms. 2025 Dec; 40(6):528-546.
Longitudinal Associations of Sedentary Behavior and Physical Activity With Diurnal Rest-Activity Rhythms in Survivors of Colorectal Cancer Up to 5 Years Post-Treatment.
Romo-Nava F, Burgess HJ, Blom TJ, Georgiev G, Stoddard J, McMillan E, Mori NN, Charnas C, Guerdjikova AI, McNamara RK, Welge JA, Grilo CM, Scheer FAJL, McElroy SL
Sleep advances : a journal of the Sleep Research Society
Home-based dim light melatonin onset assessment among adults with obesity: feasibility and procedural considerations. Sleep Adv. 2025; 6(3):zpaf047.
Home-based dim light melatonin onset assessment among adults with obesity: feasibility and procedural considerations.
Windred DP, Burns AC, Rutter MK, Lane JM, Saxena R, Scheer FAJL, Cain SW, Phillips AJK
Light Exposure at Night and Cardiovascular Disease Incidence. JAMA Netw Open. 2025 Oct 01; 8(10):e2539031.
Light Exposure at Night and Cardiovascular Disease Incidence.
Scheer F, Lüdtke CW, Kamusella P, Wiggermann P, Vieweg H, Schlöricke E, Lichtenberg M, Andresen R, Wissgott C
Combination of rotational atherothrombectomy and Paclitaxel-coated angioplasty for femoropopliteal occlusion. Clin Med Insights Cardiol. 2014; 8(Suppl 2):43-8.
Combination of rotational atherothrombectomy and Paclitaxel-coated angioplasty for femoropopliteal occlusion.
De la Peña-Armada R, Rodríguez-Martín M, Dashti HS, Cascales AI, Scheer FAJL, Saxena R, Garaulet M
Early meal timing attenuates high polygenic risk of obesity. Obesity (Silver Spring). 2025 Aug; 33(8):1555-1566.
Early meal timing attenuates high polygenic risk of obesity.
Social time pressure, sleep, and eating rhythms-lessons from a pandemic "natural experiment". Sleep. 2025 Dec 11; 48(12).
Social time pressure, sleep, and eating rhythms-lessons from a pandemic "natural experiment".
Manoogian ENC, Peterson CM, Sears DD, Playdon M, Banks S, Bonham M, Chaix A, Chow LS, Coletta A, De Cabo R, Desplats P, Dibner C, Gabel K, Johnson SL, Kriegsfeld LJ, Hardikar S, Hawley JA, Heilbronn LK, Hogenesch J, James DL, Kleckner AS, Laferrère B, Marinac C, Panda S, Parr E, Pendergast JS, Quist JS, Ravussin E, Scheer FAJL, Swiatkiewicz I, Takahashi JS, Taub PR, Termannsen AD, Varady KA, Wilkinson MJ, Zee PC, Collet TH
Short-term 24h dietary recalls from observational studies cannot support claims on mortality. Diabetes Metab Syndr. 2025 Oct; 19(10):103316.
Short-term 24h dietary recalls from observational studies cannot support claims on mortality.
Shea SA, Scheer FAJL, Gumz ML, Eikenberry SA, Qian J, Thosar SS, Sole MJ, Martino TA
Unlocking the potential of circadian biology for cardiovascular health. Physiol Rev. 2026 Jul 01; 106(3):1195-1262.
Unlocking the potential of circadian biology for cardiovascular health.
Current opinion in endocrinology, diabetes, and obesity
Metabolic effects of sleep disruption, links to obesity and diabetes. Curr Opin Endocrinol Diabetes Obes. 2014 Aug; 21(4):293-8.
Metabolic effects of sleep disruption, links to obesity and diabetes.
Department of Medicine, Brigham and Women’s Hospital
Nominated for the 2024 DOM Kenneth Baughman Mentoring Award
• The Independent: Eating only during daytime could help protect shift workers heart health – study
• Medscape: Sleeping With the Light On May Increase Heart Disease Risk
Medscape: “How Nighttime Light Quietly Became a Serious Health Threat
Rubio-Sastre P, Scheer FA, Gómez-Abellán P, Madrid JA, Garaulet M
Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening. Sleep. 2014 Oct 01; 37(10):1715-9.
Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening.
Mattson MP, Allison DB, Fontana L, Harvie M, Longo VD, Malaisse WJ, Mosley M, Notterpek L, Ravussin E, Scheer FA, Seyfried TN, Varady KA, Panda S
Meal frequency and timing in health and disease. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16647-53.
Meal frequency and timing in health and disease.
Dashti HS, Follis JL, Smith CE, Tanaka T, Cade BE, Gottlieb DJ, Hruby A, Jacques PF, Lamon-Fava S, Richardson K, Saxena R, Scheer FA, Kovanen L, Bartz TM, Perälä MM, Jonsson A, Frazier-Wood AC, Kalafati IP, Mikkilä V, Partonen T, Lemaitre RN, Lahti J, Hernandez DG, Toft U, Johnson WC, Kanoni S, Raitakari OT, Perola M, Psaty BM, Ferrucci L, Grarup N, Highland HM, Rallidis L, Kähönen M, Havulinna AS, Siscovick DS, Räikkönen K, Jørgensen T, Rotter JI, Deloukas P, Viikari JS, Mozaffarian D, Linneberg A, Seppälä I, Hansen T, Salomaa V, Gharib SA, Eriksson JG, Bandinelli S, Pedersen O, Rich SS, Dedoussis G, Lehtimäki T, Ordovás JM
Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants. Am J Clin Nutr. 2015 Jan; 101(1):135-43.
Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants.
Rahman SA, Castanon-Cervantes O, Scheer FA, Shea SA, Czeisler CA, Davidson AJ, Lockley SW
Endogenous circadian regulation of pro-inflammatory cytokines and chemokines in the presence of bacterial lipopolysaccharide in humans. Brain Behav Immun. 2015 Jul; 47:4-13.
Endogenous circadian regulation of pro-inflammatory cytokines and chemokines in the presence of bacterial lipopolysaccharide in humans.
Morris CJ, Yang JN, Garcia JI, Myers S, Bozzi I, Wang W, Buxton OM, Shea SA, Scheer FA
Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans. Proc Natl Acad Sci U S A. 2015 Apr 28; 112(17):E2225-34.
Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans.
Bandín C, Scheer FA, Luque AJ, Ávila-Gandía V, Zamora S, Madrid JA, Gómez-Abellán P, Garaulet M
Meal timing affects glucose tolerance, substrate oxidation and circadian-related variables: A randomized, crossover trial. Int J Obes (Lond). 2015 May; 39(5):828-33.
Meal timing affects glucose tolerance, substrate oxidation and circadian-related variables: A randomized, crossover trial.
Gu C, Coomans CP, Hu K, Scheer FA, Stanley HE, Meijer JH
Lack of exercise leads to significant and reversible loss of scale invariance in both aged and young mice. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2320-4.
Lack of exercise leads to significant and reversible loss of scale invariance in both aged and young mice.
Dashti HS, Follis JL, Smith CE, Tanaka T, Garaulet M, Gottlieb DJ, Hruby A, Jacques PF, Kiefte-de Jong JC, Lamon-Fava S, Scheer FA, Bartz TM, Kovanen L, Wojczynski MK, Frazier-Wood AC, Ahluwalia TS, Perälä MM, Jonsson A, Muka T, Kalafati IP, Mikkilä V, Ordovás JM
Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits. Diabetes Care. 2015 Aug; 38(8):1456-66.
Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits.
Burke TM, Scheer FAJL, Ronda JM, Czeisler CA, Wright KP
Sleep inertia, sleep homeostatic and circadian influences on higher-order cognitive functions. J Sleep Res. 2015 Aug; 24(4):364-371.
Sleep inertia, sleep homeostatic and circadian influences on higher-order cognitive functions.
Nominated for the 2013-2014 Harold Amos Faculty Diversity Award, Harvard Medical School
Nominated for 2014-2015 A. Clifford Barger Excellence in Mentoring Award, Harvard Medical School
Morris CJ, Garcia JI, Myers S, Yang JN, Trienekens N, Scheer FA
The Human Circadian System Has a Dominating Role in Causing the Morning/Evening Difference in Diet-Induced Thermogenesis. Obesity (Silver Spring). 2015 Oct; 23(10):2053-8.
The Human Circadian System Has a Dominating Role in Causing the Morning/Evening Difference in Diet-Induced Thermogenesis.
Garaulet M, Gómez-Abellán P, Rubio-Sastre P, Madrid JA, Saxena R, Scheer FA
Common type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans. Metabolism. 2015 Dec; 64(12):1650-7.
Common type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans.
Dashti HS, Scheer FA, Jacques PF, Lamon-Fava S, Ordovás JM
Short sleep duration and dietary intake: epidemiologic evidence, mechanisms, and health implications. Adv Nutr. 2015 Nov; 6(6):648-59.
Short sleep duration and dietary intake: epidemiologic evidence, mechanisms, and health implications.
Dashti HS, Aslibekyan S, Scheer FA, Smith CE, Lamon-Fava S, Jacques P, Lai CQ, Tucker KL, Arnett DK, Ordovás JM
Clock Genes Explain a Large Proportion of Phenotypic Variance in Systolic Blood Pressure and This Control Is Not Modified by Environmental Temperature. Am J Hypertens. 2016 Jan; 29(1):132-40.
Clock Genes Explain a Large Proportion of Phenotypic Variance in Systolic Blood Pressure and This Control Is Not Modified by Environmental Temperature.
Arble DM, Bass J, Behn CD, Butler MP, Challet E, Czeisler C, Depner CM, Elmquist J, Franken P, Grandner MA, Hanlon EC, Keene AC, Joyner MJ, Karatsoreos I, Kern PA, Klein S, Morris CJ, Pack AI, Panda S, Ptacek LJ, Punjabi NM, Sassone-Corsi P, Scheer FA, Saxena R, Seaquest ER, Thimgan MS, Van Cauter E, Wright KP
Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions. Sleep. 2015 Dec 01; 38(12):1849-60.
Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions.
Circadian misalignment increases cardiovascular disease risk factors in humans. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):E1402-11.
Circadian misalignment increases cardiovascular disease risk factors in humans.
Lane JM, Vlasac I, Anderson SG, Kyle SD, Dixon WG, Bechtold DA, Gill S, Little MA, Luik A, Loudon A, Emsley R, Scheer FA, Lawlor DA, Redline S, Ray DW, Rutter MK, Saxena R
Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank. Nat Commun. 2016 Mar 09; 7:10889.
Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank.
Morris CJ, Purvis TE, Mistretta J, Scheer FA
Effects of the Internal Circadian System and Circadian Misalignment on Glucose Tolerance in Chronic Shift Workers. J Clin Endocrinol Metab. 2016 Mar; 101(3):1066-74.
Effects of the Internal Circadian System and Circadian Misalignment on Glucose Tolerance in Chronic Shift Workers.
Lane JM, Chang AM, Bjonnes AC, Aeschbach D, Anderson C, Cade BE, Cain SW, Czeisler CA, Gharib SA, Gooley JJ, Gottlieb DJ, Grant SF, Klerman EB, Lauderdale DS, Lockley SW, Munch M, Patel S, Punjabi NM, Rajaratnam SM, Rueger M, St Hilaire MA, Santhi N, Scheuermaier K, Van Reen E, Zee PC, Shea SA, Duffy JF, Buxton OM, Redline S, Scheer FA, Saxena R
Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology. Diabetes. 2016 06; 65(6):1741-51.
Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology.
Johnston JD, Ordovás JM, Scheer FA, Turek FW
Circadian Rhythms, Metabolism, and Chrononutrition in Rodents and Humans. Adv Nutr. 2016 Mar; 7(2):399-406.
Circadian Rhythms, Metabolism, and Chrononutrition in Rodents and Humans.
Hungry for Sleep: A Role for Endocannabinoids? Sleep. 2016 Mar 01; 39(3):495-6.
Hungry for Sleep: A Role for Endocannabinoids?
Circadian System and Glucose Metabolism: Implications for Physiology and Disease. Trends Endocrinol Metab. 2016 05; 27(5):282-293.
Circadian System and Glucose Metabolism: Implications for Physiology and Disease.
Chang AM, Bjonnes AC, Aeschbach D, Buxton OM, Gooley JJ, Anderson C, Van Reen E, Cain SW, Czeisler CA, Duffy JF, Lockley SW, Shea SA, Scheer FA, Saxena R
Circadian gene variants influence sleep and the sleep electroencephalogram in humans. Chronobiol Int. 2016; 33(5):561-73.
Circadian gene variants influence sleep and the sleep electroencephalogram in humans.
Hu K, Riemersma-van der Lek RF, Patxot M, Li P, Shea SA, Scheer FA, Van Someren EJ
Progression of Dementia Assessed by Temporal Correlations of Physical Activity: Results From a 3.5-Year, Longitudinal Randomized Controlled Trial. Sci Rep. 2016 06 13; 6:27742.
Progression of Dementia Assessed by Temporal Correlations of Physical Activity: Results From a 3.5-Year, Longitudinal Randomized Controlled Trial.
Dashti HS, Zuurbier LA, de Jonge E, Voortman T, Jacques PF, Lamon-Fava S, Scheer FA, Kiefte-De Jong JC, Hofman A, Ordovás JM, Franco OH, Tiemeier H
Actigraphic sleep fragmentation, efficiency and duration associate with dietary intake in the Rotterdam Study. J Sleep Res. 2016 08; 25(4):404-11.
Actigraphic sleep fragmentation, efficiency and duration associate with dietary intake in the Rotterdam Study.
Carrasco-Benso MP, Rivero-Gutierrez B, Lopez-Minguez J, Anzola A, Diez-Noguera A, Madrid JA, Lujan JA, Martínez-Augustin O, Scheer FA, Garaulet M
Human adipose tissue expresses intrinsic circadian rhythm in insulin sensitivity. FASEB J. 2016 09; 30(9):3117-23.
Human adipose tissue expresses intrinsic circadian rhythm in insulin sensitivity.
Mechanisms underlying adverse health consequences of shift work
Melatonin Supplementation in Hypertensive Patients
Development of countermeasures against adverse metabolic effects of shift work
Melatonin and Receptor Gene Variant: Linking Circadian System and Type 2 Diabetes
Impact of Malatonin, Food Timing and Receptor Variant on Type 2 Diabetes Risk
Impact of MTNR1B and CRY2 variants on sleep circadian physiology and metabolism
van Moorsel D, Hansen J, Havekes B, Scheer FAJL, Jörgensen JA, Hoeks J, Schrauwen-Hinderling VB, Duez H, Lefebvre P, Schaper NC, Hesselink MKC, Staels B, Schrauwen P
Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity. Mol Metab. 2016 Aug; 5(8):635-645.
Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity.
Ruiz-Lozano T, Vidal J, de Hollanda A, Scheer FAJL, Garaulet M, Izquierdo-Pulido M
Timing of food intake is associated with weight loss evolution in severe obese patients after bariatric surgery. Clin Nutr. 2016 12; 35(6):1308-1314.
Timing of food intake is associated with weight loss evolution in severe obese patients after bariatric surgery.
Lane JM, Liang J, Vlasac I, Anderson SG, Bechtold DA, Bowden J, Emsley R, Gill S, Little MA, Luik AI, Loudon A, Scheer FA, Purcell SM, Kyle SD, Lawlor DA, Zhu X, Redline S, Ray DW, Rutter MK, Saxena R
Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits. Nat Genet. 2017 Feb; 49(2):274-281.
Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits.
Neal Miller Award, Academy of Behavioral Medicine Research
National Sleep Foundation/Sleep Research Socie
1st Place Clinical Research Young Investigator Award, National Sleep Foundation/Sleep Research Socie
Alliance Chronosleep Award, European Sleep Research Society
Young Investigator Neurology Section Award, American Academy of Sleep Medicine
Finalist Helgi Kristbjarnarson's Award, European Sleep Research Society
Young Investigator Award, American Academy of Sleep Medicine
Pickwick Postdoctoral Fellowship, National Sleep Foundation
Young Investigator Award, Honorable Mention, Sleep Research Society
Light and diurnal cycle affect human heart rate: possible role for the circadian pacemaker. J Biol Rhythms. 1999 Jun; 14(3):202-12.
Light and diurnal cycle affect human heart rate: possible role for the circadian pacemaker.
Scheer FA, Van Montfrans GA, van Someren EJ, Mairuhu G, Buijs RM
Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension. 2004 Feb; 43(2):192-7.
Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension.
Scheer F, Spunar P, Wiggermann P, Wissgott C, Andresen R
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
Mesenteric Panniculitis (MP) in CT - A Predictor of Malignancy? Rofo. 2016 Oct; 188(10):926-32.
Mesenteric Panniculitis (MP) in CT - A Predictor of Malignancy?
Ohayon M, Wickwire EM, Hirshkowitz M, Albert SM, Avidan A, Daly FJ, Dauvilliers Y, Ferri R, Fung C, Gozal D, Hazen N, Krystal A, Lichstein K, Mallampalli M, Plazzi G, Rawding R, Scheer FA, Somers V, Vitiello MV
National Sleep Foundation's sleep quality recommendations: first report. Sleep Health. 2017 02; 3(1):6-19.
National Sleep Foundation's sleep quality recommendations: first report.
Morris CJ, Purvis TE, Mistretta J, Hu K, Scheer FAJL
Circadian Misalignment Increases C-Reactive Protein and Blood Pressure in Chronic Shift Workers. J Biol Rhythms. 2017 04; 32(2):154-164.
Circadian Misalignment Increases C-Reactive Protein and Blood Pressure in Chronic Shift Workers.
Light affects morning salivary cortisol in humans. J Clin Endocrinol Metab. 1999 Sep; 84(9):3395-8.
Light affects morning salivary cortisol in humans.
Scheer FA, Van Paassen B, Van Montfrans GA, Fliers E, Van Someren EJ, Van Heerikhuize JJ, Buijs RM
Human basal cortisol levels are increased in hospital compared to home setting. Neurosci Lett. 2002 Nov 22; 333(2):79-82.
Human basal cortisol levels are increased in hospital compared to home setting.
Kalsbeek A, Palm IF, La Fleur SE, Scheer FA, Perreau-Lenz S, Ruiter M, Kreier F, Cailotto C, Buijs RM
SCN outputs and the hypothalamic balance of life. J Biol Rhythms. 2006 Dec; 21(6):458-69.
SCN outputs and the hypothalamic balance of life.
Decreased sleep in heart failure: are medications to blame? Arch Intern Med. 2007 May 28; 167(10):1098-9; author reply 1099-100.
Decreased sleep in heart failure: are medications to blame?
Scheer FA, Wright KP, Kronauer RE, Czeisler CA
Plasticity of the intrinsic period of the human circadian timing system. PLoS One. 2007 Aug 08; 2(8):e721.
Plasticity of the intrinsic period of the human circadian timing system.
Scheer FA, Ter Horst GJ, van Der Vliet J, Buijs RM
American journal of physiology. Heart and circulatory physiology
Physiological and anatomic evidence for regulation of the heart by suprachiasmatic nucleus in rats. Am J Physiol Heart Circ Physiol. 2001 Mar; 280(3):H1391-9.
Physiological and anatomic evidence for regulation of the heart by suprachiasmatic nucleus in rats.
Scheer FA, Michelson AD, Frelinger AL, Evoniuk H, Kelly EE, McCarthy M, Doamekpor LA, Barnard MR, Shea SA
The human endogenous circadian system causes greatest platelet activation during the biological morning independent of behaviors. PLoS One. 2011; 6(9):e24549.
The human endogenous circadian system causes greatest platelet activation during the biological morning independent of behaviors.
Circadian system, sleep and endocrinology. Mol Cell Endocrinol. 2012 Feb 05; 349(1):91-104.
Circadian system, sleep and endocrinology.
Shea SA, Hilton MF, Scheer FA, Ayers R, Evoniuk HL, Shiels SA, Sugarbaker RJ, Malhotra A, Massaro AF.
An endogenous circadian rhythm in bronchodilator rescue medication use in asthma. Sleep. 2004; 27:A81.
An endogenous circadian rhythm in bronchodilator rescue medication use in asthma
Autonomic neuroscience : basic & clinical
Light and diurnal cycle affect autonomic cardiac balance in human; possible role for the biological clock. Auton Neurosci. 2004 Jan 30; 110(1):44-8.
Light and diurnal cycle affect autonomic cardiac balance in human; possible role for the biological clock.
Scheer FA, Pirovano C, Van Someren EJ, Buijs RM
Environmental light and suprachiasmatic nucleus interact in the regulation of body temperature. Neuroscience. 2005; 132(2):465-77.
Environmental light and suprachiasmatic nucleus interact in the regulation of body temperature.
Melatonin, sleep, and circadian rhythms. Sleep Med Rev. 2005 Feb; 9(1):5-9.
Melatonin, sleep, and circadian rhythms.
Jeyaraj D, Scheer FA, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee HG, Smith MA, Casadesus G, Mintz EM, Sun H, Wang Y, Ramsey KM, Bass J, Shea SA, Albrecht U, Jain MK
Klf15 orchestrates circadian nitrogen homeostasis. Cell Metab. 2012 Mar 07; 15(3):311-23.
Klf15 orchestrates circadian nitrogen homeostasis.
Cardiovascular control by the suprachiasmatic nucleus: neural and neuroendocrine mechanisms in human and rat. Biol Chem. 2003 May; 384(5):697-709.
Cardiovascular control by the suprachiasmatic nucleus: neural and neuroendocrine mechanisms in human and rat.
Frank A.J.L. Scheer, Thomas J. Shea, Heather L. Evoniuk, Michael F. Hilton
Circadian Rhythm in Degree of Sleep Inertia Following Awakening. J Sleep Res. 2006; 15(1):55.
Circadian Rhythm in Degree of Sleep Inertia Following Awakening
Jung CM, Khalsa S, Scheer FA, Czeisler CA, Wright KP.
Acute effects of bright light exposure on nighttime cortisol levels in humans. Sleep. 2005; 28:A59.
Acute effects of bright light exposure on nighttime cortisol levels in humans
Circadian Biology: Uncoupling Human Body Clocks by Food Timing. Curr Biol. 2017 07 10; 27(13):R656-R658.
Circadian Biology: Uncoupling Human Body Clocks by Food Timing.
Hu K, Scheer FA, Ivanov PCh, Buijs RM, Shea SA
The suprachiasmatic nucleus functions beyond circadian rhythm generation. Neuroscience. 2007 Nov 09; 149(3):508-17.
The suprachiasmatic nucleus functions beyond circadian rhythm generation.
Buijs RM, Scheer FA, Kreier F, Yi C, Bos N, Goncharuk VD, Kalsbeek A
Organization of circadian functions: interaction with the body. Prog Brain Res. 2006; 153:341-60.
Organization of circadian functions: interaction with the body.
Kalsbeek A, Scheer FA, Perreau-Lenz S, La Fleur SE, Yi CX, Fliers E, Buijs RM
Circadian disruption and SCN control of energy metabolism. FEBS Lett. 2011 May 20; 585(10):1412-26.
Circadian disruption and SCN control of energy metabolism.
Lo MT, Bandin C, Yang HW, Scheer FAJL, Hu K, Garaulet M
CLOCK 3111T/C genetic variant influences the daily rhythm of autonomic nervous function: relevance to body weight control. Int J Obes (Lond). 2018 02; 42(2):190-197.
CLOCK 3111T/C genetic variant influences the daily rhythm of autonomic nervous function: relevance to body weight control.
Li P, Morris CJ, Patxot M, Yugay T, Mistretta J, Purvis TE, Scheer FAJL, Hu K
Reduced Tolerance to Night Shift in Chronic Shift Workers: Insight From Fractal Regulation. Sleep. 2017 07 01; 40(7).
Reduced Tolerance to Night Shift in Chronic Shift Workers: Insight From Fractal Regulation.
Dashti HS, Follis JL, Smith CE, Tanaka T, Garaulet M, Gottlieb DJ, Hruby A, Jacques PF, Kiefte-de Jong JC, Lamon-Fava S, Scheer FAJL, Bartz TM, Kovanen L, Wojczynski MK, Frazier-Wood AC, Ahluwalia TS, Perälä MM, Jonsson A, Muka T, Kalafati IP, Mikkilä V, Ordovás JM
Erratum. Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits. Diabetes Care 2015;38:1456-1466. Diabetes Care. 2017 10; 40(10):1420.
Erratum. Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits. Diabetes Care 2015;38:1456-1466.
McHill AW, Phillips AJ, Czeisler CA, Keating L, Yee K, Barger LK, Garaulet M, Scheer FA, Klerman EB
Later circadian timing of food intake is associated with increased body fat. Am J Clin Nutr. 2017 Nov; 106(5):1213-1219.
Later circadian timing of food intake is associated with increased body fat.
Role of Meal Timing in Efficacy of Bariatric Surgery in Obese Individuals
Influence of the Circadian System on Disease Severity. Sleep Med Clin. 2009 Jun 01; 4(2):143-163.
Influence of the Circadian System on Disease Severity.
Lopez-Minguez J, Saxena R, Bandín C, Scheer FA, Garaulet M
Late dinner impairs glucose tolerance in MTNR1B risk allele carriers: A randomized, cross-over study. Clin Nutr. 2018 08; 37(4):1133-1140.
Late dinner impairs glucose tolerance in MTNR1B risk allele carriers: A randomized, cross-over study.
Scheer FA, Zeitzer JM, Ayas NT, Brown R, Czeisler CA, Shea SA
Reduced sleep efficiency in cervical spinal cord injury; association with abolished night time melatonin secretion. Spinal Cord. 2006 Feb; 44(2):78-81.
Reduced sleep efficiency in cervical spinal cord injury; association with abolished night time melatonin secretion.
An endogenous circadian rhythm in sleep inertia results in greatest cognitive impairment upon awakening during the biological night. J Biol Rhythms. 2008 Aug; 23(4):353-61.
An endogenous circadian rhythm in sleep inertia results in greatest cognitive impairment upon awakening during the biological night.
The human circadian system adapts to prior photic history. J Physiol. 2011 Mar 01; 589(Pt 5):1095-102.
The human circadian system adapts to prior photic history.
Suprachiasmatic nucleus, environmental light, and metabolic state interact in the regulation of body temperature. J Sleep Res. 2006; 20.
Kun Hu, Frank A.J.L. Scheer, Plamen Ch. Ivanov, Ruud M. Buijs, Steven A. Shea
Intrinsic scale-invariant patterns of locomotor activity: role of the circadian pacemaker across a wide range of time scales – spanning 4-24 hours. Sleep. 2006; 29:A64.
Intrinsic scale-invariant patterns of locomotor activity: role of the circadian pacemaker across a wide range of time scales – spanning 4-24 hours
Joustra SD, Gu C, Rohling JHT, Pickering L, Klose M, Hu K, Scheer FA, Feldt-Rasmussen U, Jennum PJ, Pereira AM, Biermasz NR, Meijer JH
Decrease in scale invariance of activity fluctuations with aging and in patients with suprasellar tumors. Chronobiol Int. 2018 03; 35(3):368-377.
Decrease in scale invariance of activity fluctuations with aging and in patients with suprasellar tumors.
Lockley SW, Evans EE, Scheer FA, Brainard GC, Czeisler CA, Aeschbach D
Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans. Sleep. 2006 Feb; 29(2):161-8.
Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans.
Effect of lesioning the suprachiasmatic nucleus on fractal pattern of heart rate fluctuations. Sleep. 2007; 30:A64.
Effect of lesioning the suprachiasmatic nucleus on fractal pattern of heart rate fluctuations
Collado MC, Engen PA, Bandín C, Cabrera-Rubio R, Voigt RM, Green SJ, Naqib A, Keshavarzian A, Scheer FAJL, Garaulet M
Timing of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study. FASEB J. 2018 04; 32(4):2060-2072.
Timing of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study.
Tucker MA, Morris CJ, Morgan A, Yang J, Myers S, Pierce JG, Stickgold R, Scheer FAJL
The Relative Impact of Sleep and Circadian Drive on Motor Skill Acquisition and Memory Consolidation. Sleep. 2017 04 01; 40(4).
The Relative Impact of Sleep and Circadian Drive on Motor Skill Acquisition and Memory Consolidation.
Hu K, Scheer FA, Laker M, Smales C, Shea SA
Endogenous circadian rhythm in vasovagal response to head-up tilt. Circulation. 2011 Mar 08; 123(9):961-70.
Endogenous circadian rhythm in vasovagal response to head-up tilt.
Scheer FAJL, Wright Jr. KP, Gronfier C, Kronauer RE, Czeisler CA
Human circadian period is influenced by entrainment to non-24 hour schedules. Sleep. 2005; 28:A72.
Human circadian period is influenced by entrainment to non-24 hour schedules
Vera B, Dashti HS, Gómez-Abellán P, Hernández-Martínez AM, Esteban A, Scheer FAJL, Saxena R, Garaulet M
Modifiable lifestyle behaviors, but not a genetic risk score, associate with metabolic syndrome in evening chronotypes. Sci Rep. 2018 01 17; 8(1):945.
Modifiable lifestyle behaviors, but not a genetic risk score, associate with metabolic syndrome in evening chronotypes.
Scheer FAJL, Hahn M, Doamekpor LA, Evoniuk H, Kelly K, Laker MD, Shea SA.
Lack of endogenous circadian rhythm of platelet aggregability. Sleep. 2007; 30:A64.
Lack of endogenous circadian rhythm of platelet aggregability
Pavlova MK, Shea SA, Scheer FA, Bromfield EB
Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy? Epilepsy Behav. 2009 Nov; 16(3):461-7.
Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy?
Hu K, Meijer JH, Shea SA, vanderLeest HT, Pittman-Polletta B, Houben T, van Oosterhout F, Deboer T, Scheer FA
Fractal patterns of neural activity exist within the suprachiasmatic nucleus and require extrinsic network interactions. PLoS One. 2012; 7(11):e48927.
Fractal patterns of neural activity exist within the suprachiasmatic nucleus and require extrinsic network interactions.
Daily circadian misalignment impairs human cognitive performance task-dependently. Sci Rep. 2018 02 14; 8(1):3041.
Daily circadian misalignment impairs human cognitive performance task-dependently.
Thomas J Shea, Michael F Hilton, Heather L Evoniuk, Frank AJL Scheer
Circadian Effect on Degree of Sleep Inertia Present After Awakening. Sleep. 2006; 29:A67.
Circadian Effect on Degree of Sleep Inertia Present After Awakening