Associate Professor of Pediatrics, Part-time
Yuan Q, Gurish MF, Friend DS, Austen KF, Boyce JA
Journal of immunology (Baltimore, Md. : 1950)
Generation of a novel stem cell factor-dependent mast cell progenitor. J Immunol. 1998 Nov 15; 161(10):5143-6.
Generation of a novel stem cell factor-dependent mast cell progenitor.
Heller EA, Liu E, Tager AM, Yuan Q, Lin AY, Ahluwalia N, Jones K, Koehn SL, Lok VM, Aikawa E, Moore KJ, Luster AD, Gerszten RE
Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells. Circulation. 2006 May 16; 113(19):2301-12.
Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells.
Current Pediatric Therapy. Eds. Burg, Ingelfinger, Polin and Gershon.
Gastroesophageal Reflux. Current Pediatric Therapy. Eds. Burg, Ingelfinger, Polin and Gershon. 2002; 583-585.
Pediatric and Adolescent GERD. Current GERD Reports. 2007; In press.
Antibiotics and Acid-Suppressing Medications in Early Life and Allergic Disorders. JAMA Pediatr. 2018 10 01; 172(10):989-990.
Antibiotics and Acid-Suppressing Medications in Early Life and Allergic Disorders.
Textbook of Pediatric Gastroenerology and Nutrition. Ed. Guandalini
Crohn's Disease. Textbook of Pediatric Gastroenerology and Nutrition. Ed. Guandalini. 2004; 347-378.
Selective Summary. Insight of milk protein allergy: microenvironment matters. Gastroenterology. 2003; 124:259-261.
Selective Summary. Insight of milk protein allergy: microenvironment matters
Leung E, Mead PE, Yuan Q, Jiang WM, Watson JD, Krissansen GW
The mouse beta 7 integrin gene promoter: transcriptional regulation of the leukocyte integrins LPAM-1 and M290. Int Immunol. 1993 May; 5(5):551-8.
The mouse beta 7 integrin gene promoter: transcriptional regulation of the leukocyte integrins LPAM-1 and M290.
Kang D, Do D, Ryu J, Grant CN, Giddings SL, Rosenberg M, Hesterberg PE, Yuan Q, Garber JJ, Katz AJ, Tearney GJ
A miniaturized, tethered, spectrally-encoded confocal endomicroscopy capsule. Lasers Surg Med. 2019 Jul; 51(5):452-458.
A miniaturized, tethered, spectrally-encoded confocal endomicroscopy capsule.
Harvard T.H. Chan School of Public Health
Elkan Blout Professor of Environmental Genetics
Carlos Arturo Camargo, Jr., Dr.P.H., M.D.
S. Jean Emans, MD, Professor of Pediatrics
Adolph M. Hutter Jr. Professor of Medicine in the Field of Cardiology
Martin VM, Virkud YV, Seay H, Hickey A, Ndahayo R, Rosow R, Southwick C, Elkort M, Gupta B, Kramer E, Pronchick T, Reuter S, Keet C, Su KW, Shreffler WG, Yuan Q
The journal of allergy and clinical immunology. In practice
Prospective Assessment of Pediatrician-Diagnosed Food Protein-Induced Allergic Proctocolitis by Gross or Occult Blood. J Allergy Clin Immunol Pract. 2020 05; 8(5):1692-1699.e1.
Prospective Assessment of Pediatrician-Diagnosed Food Protein-Induced Allergic Proctocolitis by Gross or Occult Blood.
Su KW, Patil SU, Stockbridge JL, Martin VM, Virkud YV, Huang JL, Shreffler WG, Yuan Q
The Journal of allergy and clinical immunology
Food aversion and poor weight gain in food protein-induced enterocolitis syndrome: A retrospective study. J Allergy Clin Immunol. 2020 05; 145(5):1430-1437.e11.
Food aversion and poor weight gain in food protein-induced enterocolitis syndrome: A retrospective study.
Wang Z, Du M, Yuan Q, Guo Y, Hutchinson JN, Su L, Zheng Y, Wang J, Mucci LA, Lin X, Hou L, Christiani DC
Epigenomic analysis of 5-hydroxymethylcytosine (5hmC) reveals novel DNA methylation markers for lung cancers. Neoplasia. 2020 03; 22(3):154-161.
Epigenomic analysis of 5-hydroxymethylcytosine (5hmC) reveals novel DNA methylation markers for lung cancers.
Martin VM, Virkud YV, Phadke NA, Su KW, Seay H, Atkins MR, Keet C, Shreffler WG, Yuan Q
Increased IgE-Mediated Food Allergy With Food Protein-Induced Allergic Proctocolitis. Pediatrics. 2020 09; 146(3).
Increased IgE-Mediated Food Allergy With Food Protein-Induced Allergic Proctocolitis.
Zhao JL, Du ZY, Sun YR, Yuan Q, Yu J, Wu X, Li ZQ, Wu XH, Xie R, Hu J
Intensive blood pressure control reduces the risk of progressive hemorrhage in patients with acute hypertensive intracerebral hemorrhage: A retrospective observational study. Clin Neurol Neurosurg. 2019 05; 180:1-6.
Intensive blood pressure control reduces the risk of progressive hemorrhage in patients with acute hypertensive intracerebral hemorrhage: A retrospective observational study.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
Gastrointestinal immunopathology of food protein-induced enterocolitis syndrome and other non-immunoglobulin E-mediated food allergic diseases. Ann Allergy Asthma Immunol. 2021 05; 126(5):516-523.
Gastrointestinal immunopathology of food protein-induced enterocolitis syndrome and other non-immunoglobulin E-mediated food allergic diseases.
Du M, Garcia JGN, Christie JD, Xin J, Cai G, Meyer NJ, Zhu Z, Yuan Q, Zhang Z, Su L, Shen S, Dong X, Li H, Hutchinson JN, Tejera P, Lin X, Wang M, Chen F, Christiani DC
Integrative omics provide biological and clinical insights into acute respiratory distress syndrome. Intensive Care Med. 2021 07; 47(7):761-771.
Integrative omics provide biological and clinical insights into acute respiratory distress syndrome.
Yuan Q, Cai T, Hong C, Du M, Johnson BE, Lanuti M, Cai T, Christiani DC
Performance of a Machine Learning Algorithm Using Electronic Health Record Data to Identify and Estimate Survival in a Longitudinal Cohort of Patients With Lung Cancer. JAMA Netw Open. 2021 07 01; 4(7):e2114723.
Performance of a Machine Learning Algorithm Using Electronic Health Record Data to Identify and Estimate Survival in a Longitudinal Cohort of Patients With Lung Cancer.
Lains I, Zhu S, Han X, Chung W, Yuan Q, Kelly RS, Gil JQ, Katz R, Nigalye A, Kim IK, Miller JB, Carreira IM, Silva R, Vavvas DG, Miller JW, Lasky-Su J, Liang L, Husain D
Genomic-Metabolomic Associations Support the Role of LIPC and Glycerophospholipids in Age-Related Macular Degeneration. Ophthalmol Sci. 2021 Mar; 1(1).
Genomic-Metabolomic Associations Support the Role of LIPC and Glycerophospholipids in Age-Related Macular Degeneration.
Morgan DM, Ruiter B, Smith NP, Tu AA, Monian B, Stone BE, Virk-Hundal N, Yuan Q, Shreffler WG, Love JC
Clonally expanded, GPR15-expressing pathogenic effector TH2 cells are associated with eosinophilic esophagitis. Sci Immunol. 2021 08 13; 6(62).
Clonally expanded, GPR15-expressing pathogenic effector TH2 cells are associated with eosinophilic esophagitis.
Yuan Q, Du M, Loehrer E, Johnson BE, Gainor JF, Lanuti M, Li Y, Christiani DC
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Postdiagnosis BMI Change Is Associated with Non-Small Cell Lung Cancer Survival. Cancer Epidemiol Biomarkers Prev. 2022 01; 31(1):262-268.
Postdiagnosis BMI Change Is Associated with Non-Small Cell Lung Cancer Survival.
Martin VM, Marget M, Yuan Q, Shreffler WG
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
In response to Frequency of guideline-defined cow's milk allergy symptoms in infants: Secondary analysis of EAT trial data by Vincent et al. Clin Exp Allergy. 2022 04; 52(4):581-582.
In response to Frequency of guideline-defined cow's milk allergy symptoms in infants: Secondary analysis of EAT trial data by Vincent et al.
Global burden of thyroid cancer and its attributable risk factors in 204 countries and territories from 1990 to 2019. Thorac Cancer. 2021 09; 12(18):2494-2503.
Global burden of thyroid cancer and its attributable risk factors in 204 countries and territories from 1990 to 2019.
Seay HL, Martin VM, Virkud YV, Marget M, Shreffler WG, Yuan Q
Prospective associations between acid suppressive therapy and food allergy in early childhood. Clin Exp Allergy. 2022 05; 52(5):711-714.
Prospective associations between acid suppressive therapy and food allergy in early childhood.
Hou J, Zhao R, Cai T, Beaulieu-Jones B, Seyok T, Dahal K, Yuan Q, Xiong X, Bonzel CL, Fox C, Christiani DC, Jemielita T, Liao KP, Liaw KL, Cai T
Temporal Trends in Clinical Evidence of 5-Year Survival Within Electronic Health Records Among Patients With Early-Stage Colon Cancer Managed With Laparoscopy-Assisted Colectomy vs Open Colectomy. JAMA Netw Open. 2022 06 01; 5(6):e2218371.
Temporal Trends in Clinical Evidence of 5-Year Survival Within Electronic Health Records Among Patients With Early-Stage Colon Cancer Managed With Laparoscopy-Assisted Colectomy vs Open Colectomy.
Martin VM, Virkud YV, Dahan E, Seay HL, Itzkovits D, Vlamakis H, Xavier R, Shreffler WG, Yuan Q, Yassour M
Longitudinal disease-associated gut microbiome differences in infants with food protein-induced allergic proctocolitis. Microbiome. 2022 09 23; 10(1):154.
Longitudinal disease-associated gut microbiome differences in infants with food protein-induced allergic proctocolitis.
John Rock Professor of Climate and Population Studies
Hong C, Liang L, Yuan Q, Cho K, Liao KP, Pencina MJ, Christiani DC, Cai T
Semi-supervised calibration of noisy event risk (SCANER) with electronic health records. J Biomed Inform. 2023 08; 144:104425.
Semi-supervised calibration of noisy event risk (SCANER) with electronic health records.
Rosow R, Virkud YV, Martin VM, Young M, Su KW, Phadke N, Shreffler WG, Yuan Q
Longitudinal assessment of early growth in children with IgE- and non-IgE-mediated food allergy in a healthy infant cohort. Ann Allergy Asthma Immunol. 2023 09; 131(3):362-368.e1.
Longitudinal assessment of early growth in children with IgE- and non-IgE-mediated food allergy in a healthy infant cohort.
Marget M, Virkud YV, Shreffler WG, Martin VM, Yuan Q
Factors influencing age of common allergen introduction in early childhood. Front Pediatr. 2023; 11:1207680.
Factors influencing age of common allergen introduction in early childhood.
Du M, Xin J, Zheng R, Yuan Q, Wang Z, Liu H, Liu H, Cai G, Albanes D, Lam S, Tardon A, Chen C, Bojesen SE, Landi MT, Johansson M, Risch A, Bickeböller H, Wichmann HE, Rennert G, Arnold S, Brennan P, Field JK, Shete SS, Le Marchand L, Liu G, Andrew AS, Kiemeney LA, Zienolddiny S, Grankvist K, Johansson M, Caporaso NE, Cox A, Hong YC, Yuan JM, Schabath MB, Aldrich MC, Wang M, Shen H, Chen F, Zhang Z, Hung RJ, Amos CI, Wei Q, Lazarus P, Christiani DC
CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility. Cancer Res. 2024 02 15; 84(4):616-625.
CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility.
Marget M, Baker C, O'Connell I, Shreffler WG, Yuan Q, Martin VM
Journal of pediatric gastroenterology and nutrition
Prospective association between food protein-induced allergic proctocolitis in infancy and constipation after age 3. J Pediatr Gastroenterol Nutr. 2025 Jan; 80(1):108-112.
Prospective association between food protein-induced allergic proctocolitis in infancy and constipation after age 3.
Iyengar SR, Ebb DH, Yuan Q, Shailam R, Bhan AK
Case records of the Massachusetts General Hospital. Case 27-2013. A 6.5-month-old boy with fever, rash, and cytopenias. N Engl J Med. 2013 Aug 29; 369(9):853-63.
Case records of the Massachusetts General Hospital. Case 27-2013. A 6.5-month-old boy with fever, rash, and cytopenias.
Katz A, Virk Hundal N, Yuan Q, Shreffler W
Cow's milk allergy: a new approach needed? J Pediatr. 2013 Sep; 163(3):620-2.
Cow's milk allergy: a new approach needed?
Leung J, Hundal NV, Katz AJ, Shreffler WG, Yuan Q, Butterworth CA, Hesterberg PE
Tolerance of baked milk in patients with cow's milk-mediated eosinophilic esophagitis. J Allergy Clin Immunol. 2013 Nov; 132(5):1215-1216.e1.
Tolerance of baked milk in patients with cow's milk-mediated eosinophilic esophagitis.
Marini-Rapoport O, Andrieux L, Keswani T, Zong G, Duchen D, Yaari G, Min J, Lytle IR, Rosenberg AF, Fucile C, Kobie JJ, Piepenbrink MS, Sun T, Martin VM, Yuan Q, Shreffler WG, Seppo AE, Järvinen KM, Loeffler JR, Ward AB, Kleinstein SH, Pedersen LC, Fernández-Quintero ML, Mueller GA, Patil SU
Germline-encoded recognition of peanut underlies development of convergent antibodies in humans. Sci Transl Med. 2025 Jun 11; 17(802):eadw4148.
Germline-encoded recognition of peanut underlies development of convergent antibodies in humans.
Tabatabaei N, Kang D, Wu T, Kim M, Carruth RW, Leung J, Sauk JS, Shreffler W, Yuan Q, Katz A, Nishioka NS, Tearney GJ
Tethered confocal endomicroscopy capsule for diagnosis and monitoring of eosinophilic esophagitis. Biomed Opt Express. 2013 Dec 13; 5(1):197-207.
Tethered confocal endomicroscopy capsule for diagnosis and monitoring of eosinophilic esophagitis.
Sun T, Virkud YV, Kirpas M, Gregory K, De Paz J, O'Connell I, Yassour M, Shreffler W, Yuan Q, Martin V
Fecal calprotectin and other biomarkers are not prospectively associated with food protein-induced allergic proctocolitis. J Pediatr Gastroenterol Nutr. 2026 Jan; 82(1):42-49.
Fecal calprotectin and other biomarkers are not prospectively associated with food protein-induced allergic proctocolitis.
Khan A, Jaynes A, Ali F, Virkud Y, Sun T, O'Connell I, Shreffler W, Yuan Q, Martin V
Journal of translational gastroenterology
High Rate of Positive Fecal Occult Blood Test in Healthy Infants: A Nested Case-control Study. J Transl Gastroenterol. 2025 Dec; 3(4):229-234.
High Rate of Positive Fecal Occult Blood Test in Healthy Infants: A Nested Case-control Study.
Radano MC, Yuan Q, Katz A, Fleming JT, Kubala S, Shreffler W, Keet CA
Cesarean section and antibiotic use found to be associated with eosinophilic esophagitis. J Allergy Clin Immunol Pract. 2014 Jul-Aug; 2(4):475-477.e1.
Cesarean section and antibiotic use found to be associated with eosinophilic esophagitis.
Leung J, Mehrzad R, Hundal NV, Alejos A, Hesterberg PE, Katz AJ, Yuan Q, Shreffler WG
Longitudinal Perspective on Managing Refractory Eosinophilic Esophagitis. J Allergy Clin Immunol Pract. 2015 Nov-Dec; 3(6):951-6.
Longitudinal Perspective on Managing Refractory Eosinophilic Esophagitis.
Presumed Allergic Proctocolitis Resolves with Probiotic Monotherapy: A Report of 4 Cases. Am J Case Rep. 2016 Aug 29; 17:621-4.
Presumed Allergic Proctocolitis Resolves with Probiotic Monotherapy: A Report of 4 Cases.
Chemokin receptors and regulatory T cells in IBD
Intracellular single-chain antibody inhibits integrin VLA-4 maturation and function. Biochem J. 1996 Sep 01; 318 ( Pt 2):591-6.
Intracellular single-chain antibody inhibits integrin VLA-4 maturation and function.
Krissansen GW, Print CG, Prestidge RL, Hollander D, Yuan Q, Jiang WM, Jenkins DR, Leung E, Mead P, Yong R
Immunologic and structural relatedness of the integrin beta 7 complex and the human intraepithelial lymphocyte antigen HML-1. FEBS Lett. 1992 Jan 13; 296(1):25-8.
Immunologic and structural relatedness of the integrin beta 7 complex and the human intraepithelial lymphocyte antigen HML-1.
Yuan Q, Jiang WM, Hollander D, Leung E, Watson JD, Krissansen GW
Biochemical and biophysical research communications
Identity between the novel integrin beta 7 subunit and an antigen found highly expressed on intraepithelial lymphocytes in the small intestine. Biochem Biophys Res Commun. 1991 May 15; 176(3):1443-9.
Identity between the novel integrin beta 7 subunit and an antigen found highly expressed on intraepithelial lymphocytes in the small intestine.
Yuan Q, Jiang WM, Leung E, Hollander D, Watson JD, Krissansen GW
Molecular cloning of the mouse integrin beta 7 subunit. J Biol Chem. 1992 Apr 15; 267(11):7352-8.
Molecular cloning of the mouse integrin beta 7 subunit.
Yuan Q, Bromley SK, Means TK, Jones KJ, Hayashi F, Bhan AK, Luster AD
CCR4-dependent regulatory T cell function in inflammatory bowel disease. J Exp Med. 2007 Jun 11; 204(6):1327-34.
CCR4-dependent regulatory T cell function in inflammatory bowel disease.
Jiang WM, Jenkins D, Yuan Q, Leung E, Choo KH, Watson JD, Krissansen GW
The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1. Int Immunol. 1992 Sep; 4(9):1031-40.
The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1.
Krissansen GW, Yuan Q, Jenkins D, Jiang WM, Rooke L, Spurr NK, Eccles M, Leung E, Watson JD
Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits. Immunogenetics. 1992; 35(1):58-61.
Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits.
Worm therapy for ulcerative colitis: a possible link to regulatory T cells. J Pediatr Gastroenterol Nutr. 2005 Jul; 41(1):139-40.
Worm therapy for ulcerative colitis: a possible link to regulatory T cells.
Gastroesophagus Reflux Disease in Children. GERD/Dyspepsia. Ed. Fass. 2003; 259-261.
Gastroesophagus Reflux Disease in Children
Yuan Q, Austen KF, Friend DS, Heidtman M, Boyce JA
Human peripheral blood eosinophils express a functional c-kit receptor for stem cell factor that stimulates very late antigen 4 (VLA-4)-mediated cell adhesion to fibronectin and vascular cell adhesion molecule 1 (VCAM-1). J Exp Med. 1997 Jul 21; 186(2):313-23.
Human peripheral blood eosinophils express a functional c-kit receptor for stem cell factor that stimulates very late antigen 4 (VLA-4)-mediated cell adhesion to fibronectin and vascular cell adhesion molecule 1 (VCAM-1).
Pediatric hepatobiliary disease. Curr Opin Gastroenterol. 2003 May; 19(3):276-80.
Yuan QA, Jiang WM, Krissansen GW, Watson JD
Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains. Int Immunol. 1990; 2(11):1097-108.
Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains.
Innate immunity of the gut: mucosal defense in health and disease. J Pediatr Gastroenterol Nutr. 2004 May; 38(5):463-73.
Innate immunity of the gut: mucosal defense in health and disease.
Yuan Q, Campanella GS, Colvin RA, Hamilos DL, Jones KJ, Mathew A, Means TK, Luster AD
Membrane-bound eotaxin-3 mediates eosinophil transepithelial migration in IL-4-stimulated epithelial cells. Eur J Immunol. 2006 Oct; 36(10):2700-14.
Membrane-bound eotaxin-3 mediates eosinophil transepithelial migration in IL-4-stimulated epithelial cells.
Yuan Q, Kozak CA, Jiang WM, Hollander D, Watson JD, Krissansen GW
Genetic mapping of the gene coding for the integrin beta 7 subunit to the distal part of mouse chromosome 15. Immunogenetics. 1992; 35(6):403-7.
Genetic mapping of the gene coding for the integrin beta 7 subunit to the distal part of mouse chromosome 15.
Baker E, Sutherland GR, Jiang WM, Yuan Q, Leung E, Watson JD, Krissansen GW
Mammalian genome : official journal of the International Mammalian Genome Society
Mapping of the human integrin beta 7 gene (ITG beta 7) to 12q13.13 by non-isotopic in situ hybridization. Mamm Genome. 1992; 2(4):272-3.
Mapping of the human integrin beta 7 gene (ITG beta 7) to 12q13.13 by non-isotopic in situ hybridization.
Benor S, Russell GH, Silver M, Israel EJ, Yuan Q, Winter HS
Shortcomings of the inflammatory bowel disease Serology 7 panel. Pediatrics. 2010 Jun; 125(6):1230-6.
Shortcomings of the inflammatory bowel disease Serology 7 panel.
Pediatric Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/ Management. Ed. Wyllie and Hyams
Gastrointestinal Manifestations of Primary Immunodeficiencies. Pediatric Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/ Management. Ed. Wyllie and Hyams. 2006; 601-616.
Gastrointestinal Manifestations of Primary Immunodeficiencies
Ochi H, Hirani WM, Yuan Q, Friend DS, Austen KF, Boyce JA
T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro. J Exp Med. 1999 Jul 19; 190(2):267-80.
T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro.