TKH5TakaoHenschTakao Kurt Hensch, Ph.D.42.37937520000000-71.1158752000000013042Hensch, TakaoKurt617/384-5882Professor of Neurologycatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson9822384Hensch TK, Fagiolini M, Mataga N, Stryker MP, Baekkeskov S, Kash SFScience (New York, N.Y.)Local GABA circuit control of experience-dependent plasticity in developing visual cortex. Science. 1998 Nov 20; 282(5393):1504-8.Science1998-11-20T00:00:001998Local GABA circuit control of experience-dependent plasticity in developing visual cortex.12941442Hensch TKNeuroscience researchControlling the critical period. Neurosci Res. 2003 Sep; 47(1):17-22.Neurosci Res2003-09-01T00:00:002003Controlling the critical period.15581701Hensch TK, Fagiolini MProgress in brain researchExcitatory-inhibitory balance and critical period plasticity in developing visual cortex. Prog Brain Res. 2005; 147:115-24.Prog Brain Res2005-01-01T00:00:002005Excitatory-inhibitory balance and critical period plasticity in developing visual cortex.16141072Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki YScience (New York, N.Y.)The transcriptional landscape of the mammalian genome. Science. 2005 Sep 02; 309(5740):1559-63.Science2005-09-02T00:00:002005The transcriptional landscape of the mammalian genome.10595498Hensch TKNeuronWhisking away space in the brain. Neuron. 1999 Nov; 24(3):492-3.Neuron1999-11-01T00:00:001999Whisking away space in the brain.15451412Möhler H, Fritschy JM, Crestani F, Hensch T, Rudolph UBiochemical pharmacologySpecific GABA(A) circuits in brain development and therapy. Biochem Pharmacol. 2004 Oct 15; 68(8):1685-90.Biochem Pharmacol2004-10-15T00:00:002004Specific GABA(A) circuits in brain development and therapy.Authorship 1069270529847785Sun H, Takesian AE, Wang TT, Lippman-Bell JJ, Hensch TK, Jensen FECell reportsEarly Seizures Prematurely Unsilence Auditory Synapses to Disrupt Thalamocortical Critical Period Plasticity. Cell Rep. 2018 05 29; 23(9):2533-2540.Cell Rep2018-05-29T00:00:002018Early Seizures Prematurely Unsilence Auditory Synapses to Disrupt Thalamocortical Critical Period Plasticity.Authorship 10739971Authorship 10740454Authorship 1074156129905116Hensch TK, Quinlan EMVisual neuroscienceCritical periods in amblyopia. Vis Neurosci. 2018 01; 35:E014.Vis Neurosci2018-01-01T00:00:002018Critical periods in amblyopia.29905127Hensch TK, Quinlan EMVisual neurosciencePERSPECTIVE Critical periods in amblyopia-CORRIGENDUM. Vis Neurosci. 2018 01; 35:E024.Vis Neurosci2018-01-01T00:00:002018PERSPECTIVE Critical periods in amblyopia-CORRIGENDUM.29915196Takesian AE, Bogart LJ, Lichtman JW, Hensch TKNature neurosciencePublisher Correction: Inhibitory circuit gating of auditory critical-period plasticity. Nat Neurosci. 2018 Oct; 21(10):1495.Nat Neurosci2018-10-01T00:00:002018Publisher Correction: Inhibitory circuit gating of auditory critical-period plasticity.23077063Miyamoto H, Nakamaru-Ogiso E, Hamada K, Hensch TKThe Journal of neuroscience : the official journal of the Society for NeuroscienceSerotonergic integration of circadian clock and ultradian sleep-wake cycles. J Neurosci. 2012 Oct 17; 32(42):14794-803.J Neurosci2012-10-17T00:00:002012Serotonergic integration of circadian clock and ultradian sleep-wake cycles.16242396Hensch TKNeuronRecovery in the blink of an eye. Neuron. 2005 Oct 20; 48(2):166-8.Neuron2005-10-20T00:00:002005Recovery in the blink of an eye.19604684Hensch TK, Brand AHCurrent opinion in neurobiologyDevelopment. Editorial overview. Curr Opin Neurobiol. 2009 Apr; 19(2):109-11.Curr Opin Neurobiol2009-07-13T00:00:002009Development. Editorial overview.Authorship 10916621730175250Ogiwara I, Miyamoto H, Tatsukawa T, Yamagata T, Nakayama T, Atapour N, Miura E, Mazaki E, Ernst SJ, Cao D, Ohtani H, Itohara S, Yanagawa Y, Montal M, Yuzaki M, Inoue Y, Hensch TK, Noebels JL, Yamakawa KCommunications biologyNav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice. Commun Biol. 2018; 1:96.Commun Biol2018-07-19T00:00:002018Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.21414920Hackett TA, Barkat TR, O'Brien BM, Hensch TK, Polley DBThe Journal of neuroscience : the official journal of the Society for NeuroscienceLinking topography to tonotopy in the mouse auditory thalamocortical circuit. J Neurosci. 2011 Feb 23; 31(8):2983-95.J Neurosci2011-02-23T00:00:002011Linking topography to tonotopy in the mouse auditory thalamocortical circuit.19907494Yazaki-Sugiyama Y, Kang S, Câteau H, Fukai T, Hensch TKNatureBidirectional plasticity in fast-spiking GABA circuits by visual experience. Nature. 2009 Nov 12; 462(7270):218-21.Nature2009-11-12T00:00:002009Bidirectional plasticity in fast-spiking GABA circuits by visual experience.14993461Miyamoto H, Hensch TKMolecular interventionsReciprocal interaction of sleep and synaptic plasticity. Mol Interv. 2003 Oct; 3(7):404-17.Mol Interv2003-10-01T00:00:002003Reciprocal interaction of sleep and synaptic plasticity.Authorship 1127818587609Luo L, Hensch TK, Ackerman L, Barbel S, Jan LY, Jan YNNatureDifferential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines. Nature. 1996 Feb 29; 379(6568):837-40.Nature1996-02-29T00:00:001996Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines.11739581Mataga N, Fujishima S, Condie BG, Hensch TKThe Journal of neuroscience : the official journal of the Society for NeuroscienceExperience-dependent plasticity of mouse visual cortex in the absence of the neuronal activity-dependent marker egr1/zif268. J Neurosci. 2001 Dec 15; 21(24):9724-32.J Neurosci2001-12-15T00:00:002001Experience-dependent plasticity of mouse visual cortex in the absence of the neuronal activity-dependent marker egr1/zif268.Authorship 1122485730590449Hameed MQ, Hsieh TH, Morales-Quezada L, Lee HHC, Damar U, MacMullin PC, Hensch TK, Rotenberg ACerebral cortex (New York, N.Y. : 1991)Ceftriaxone Treatment Preserves Cortical Inhibitory Interneuron Function via Transient Salvage of GLT-1 in a Rat Traumatic Brain Injury Model. Cereb Cortex. 2019 12 17; 29(11):4506-4518.Cereb Cortex2019-12-17T00:00:002019Ceftriaxone Treatment Preserves Cortical Inhibitory Interneuron Function via Transient Salvage of GLT-1 in a Rat Traumatic Brain Injury Model.Authorship 1123021Authorship 1128539430696941Picard N, Takesian AE, Fagiolini M, Hensch TKMolecular psychiatryNMDA 2A receptors in parvalbumin cells mediate sex-specific rapid ketamine response on cortical activity. Mol Psychiatry. 2019 06; 24(6):828-838.Mol Psychiatry2019-01-29T00:00:002019NMDA 2A receptors in parvalbumin cells mediate sex-specific rapid ketamine response on cortical activity.Authorship 11307441730715234Roossien DH, Sadis BV, Yan Y, Webb JM, Min LY, Dizaji AS, Bogart LJ, Mazuski C, Huth RS, Stecher JS, Akula S, Shen F, Li Y, Xiao T, Vandenbrink M, Lichtman JW, Hensch TK, Herzog ED, Cai DBioinformatics (Oxford, England)Multispectral tracing in densely labeled mouse brain with nTracer. Bioinformatics. 2019 09 15; 35(18):3544-3546.Bioinformatics2019-09-15T00:00:002019Multispectral tracing in densely labeled mouse brain with nTracer.Otolaryngology Head and Neck SurgeryD010320Chemicals & Drugs1092470.856599ParvalbuminsD007395Anatomy2725770.681795InterneuronsAuthorship 1145227430926746McNair LF, Andersen JV, Aldana BI, Hohnholt MC, Nissen JD, Sun Y, Fischer KD, Sonnewald U, Nyberg N, Webster SC, Kapur K, Rimmele TS, Barone I, Hawks-Mayer H, Lipton JO, Hodgson NW, Hensch TK, Aoki CJ, Rosenberg PA, Waagepetersen HSThe Journal of neuroscience : the official journal of the Society for NeuroscienceDeletion of Neuronal GLT-1 in Mice Reveals Its Role in Synaptic Glutamate Homeostasis and Mitochondrial Function. J Neurosci. 2019 06 19; 39(25):4847-4863.J Neurosci2019-03-29T00:00:002019Deletion of Neuronal GLT-1 in Mice Reveals Its Role in Synaptic Glutamate Homeostasis and Mitochondrial Function.30890637Sigal YM, Bae H, Bogart LJ, Hensch TK, Zhuang XProceedings of the National Academy of Sciences of the United States of AmericaStructural maturation of cortical perineuronal nets and their perforating synapses revealed by superresolution imaging. Proc Natl Acad Sci U S A. 2019 04 02; 116(14):7071-7076.Proc Natl Acad Sci U S A2019-03-19T00:00:002019Structural maturation of cortical perineuronal nets and their perforating synapses revealed by superresolution imaging.D009473Physiology56914160.524255Neuronal PlasticityD014793Anatomy34511550.537431Visual CortexAuthorship 11490702Authorship 11489951131024251Batista G, Hensch TKFrontiers in molecular neuroscienceCritical Period Regulation by Thyroid Hormones: Potential Mechanisms and Sex-Specific Aspects. Front Mol Neurosci. 2019; 12:77.Front Mol Neurosci2019-04-05T00:00:002019Critical Period Regulation by Thyroid Hormones: Potential Mechanisms and Sex-Specific Aspects.31015467Miyamoto H, Tatsukawa T, Shimohata A, Yamagata T, Suzuki T, Amano K, Mazaki E, Raveau M, Ogiwara I, Oba-Asaka A, Hensch TK, Itohara S, Sakimura K, Kobayashi K, Kobayashi K, Yamakawa KNature communicationsImpaired cortico-striatal excitatory transmission triggers epilepsy. Nat Commun. 2019 04 23; 10(1):1917.Nat Commun2019-04-23T00:00:002019Impaired cortico-striatal excitatory transmission triggers epilepsy.D001303Anatomy1533440.733696Auditory CortexMCBNeurobiologyNeurologyMCB Board of TutorBoston Children's HospitalFaculty of Arts & SciencesHarvard Medical SchoolHebrew Rehabilitation CenterMassachusetts Eye and Ear InfirmaryHL152HenryLeeHenry Lee, M.Phil.92524Lee, HenryResearch Associate in NeurologyDBP7DanielPolleyDaniel B Polley, Ph.D.95125Polley, DanielProfessor of Otolaryngology Head and Neck Surgery11120selected publications6.752590.00437266432research areas2.278370.014763136coauthor of88.070414.395460similar toWGR1WadeRegehrWade G. Regehr, Ph.D.42.33602040000000-71.1034325000000061089Regehr, WadeBullard Professor of NeurobiologyAR45AlexanderRotenbergAlexander Rotenberg, M.D., Ph.D.42.33743600000000-71.1054470000000015104Rotenberg, AlexanderProfessor of NeurologyBLS5BernardoSabatiniBernardo Luis Sabatini, M.D., Ph.D.42.33602040000000-71.1034325000000028617Sabatini, BernardoAlice and Rodman W. Moorhead III Professor of NeurobiologyMF67MichelaFagioliniMichela Fagiolini, Ph.D.42.33743600000000-71.1054470000000015643Fagiolini, MichelaAssociate Professor of NeurologyAP10AlvaroPascual-LeoneAlvaro Pascual-Leone, M.D., Ph.D.42.34022770000000-71.1058540000000010890Pascual-Leone, AlvaroProfessor of NeurologyAuthorship 116186617MQH2MustafaHameedMustafa Qadir Hameed, M.B.,B.S.42.33743600000000-71.1054470000000049781Hameed, MustafaResearch Associate in NeurologyAuthorship 1175226631332003Artoni P, Piffer A, Vinci V, LeBlanc J, Nelson CA, Hensch TK, Fagiolini MProceedings of the National Academy of Sciences of the United States of AmericaDeep learning of spontaneous arousal fluctuations detects early cholinergic defects across neurodevelopmental mouse models and patients. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23298-23303.Proc Natl Acad Sci U S A2019-07-22T00:00:002019Deep learning of spontaneous arousal fluctuations detects early cholinergic defects across neurodevelopmental mouse models and patients.Authorship 173233132321833Maurer D, Ghloum JK, Gibson LC, Watson MR, Chen LM, Akins K, Enns JT, Hensch TK, Werker JFProceedings of the National Academy of Sciences of the United States of AmericaReduced perceptual narrowing in synesthesia. Proc Natl Acad Sci U S A. 2020 05 05; 117(18):10089-10096.Proc Natl Acad Sci U S A2020-04-22T00:00:002020Reduced perceptual narrowing in synesthesia.Authorship 1240062832404418Kalish BT, Barkat TR, Diel EE, Zhang EJ, Greenberg ME, Hensch TKProceedings of the National Academy of Sciences of the United States of AmericaSingle-nucleus RNA sequencing of mouse auditory cortex reveals critical period triggers and brakes. Proc Natl Acad Sci U S A. 2020 05 26; 117(21):11744-11752.Proc Natl Acad Sci U S A2020-05-13T00:00:002020Single-nucleus RNA sequencing of mouse auditory cortex reveals critical period triggers and brakes.Authorship 12496066Authorship 1251262832445790Yamagata T, Raveau M, Kobayashi K, Miyamoto H, Tatsukawa T, Ogiwara I, Itohara S, Hensch TK, Yamakawa KNeurobiology of diseaseCRISPR/dCas9-based Scn1a gene activation in inhibitory neurons ameliorates epileptic and behavioral phenotypes of Dravet syndrome model mice. Neurobiol Dis. 2020 07; 141:104954.Neurobiol Dis2020-05-21T00:00:002020CRISPR/dCas9-based Scn1a gene activation in inhibitory neurons ameliorates epileptic and behavioral phenotypes of Dravet syndrome model mice.Authorship 1253238832503914Reh RK, Dias BG, Nelson CA, Kaufer D, Werker JF, Kolb B, Levine JD, Hensch TKProceedings of the National Academy of Sciences of the United States of AmericaCritical period regulation across multiple timescales. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23242-23251.Proc Natl Acad Sci U S A2020-06-05T00:00:002020Critical period regulation across multiple timescales.Authorship 1600972Authorship 12680251232676666MacMullin P, Hodgson N, Damar U, Lee HHC, Hameed MQ, Dhamne SC, Hyde D, Conley GM, Morriss N, Qiu J, Mannix R, Hensch TK, Rotenberg ACerebral cortex (New York, N.Y. : 1991)Increase in Seizure Susceptibility After Repetitive Concussion Results from Oxidative Stress, Parvalbumin-Positive Interneuron Dysfunction and Biphasic Increases in Glutamate/GABA Ratio. Cereb Cortex. 2020 11 03; 30(12):6108-6120.Cereb Cortex2020-11-03T00:00:002020Increase in Seizure Susceptibility After Repetitive Concussion Results from Oxidative Stress, Parvalbumin-Positive Interneuron Dysfunction and Biphasic Increases in Glutamate/GABA Ratio.true1Professor of NeurobiologyProfessor of NeurobiologyAuthorship 1597391Authorship 1341291233752869Reh RK, Hensch TK, Werker JFCognitionDistributional learning of speech sound categories is gated by sensitive periods. Cognition. 2021 08; 213:104653.Cognition2021-03-19T00:00:002021Distributional learning of speech sound categories is gated by sensitive periods.Authorship 13490354Authorship 1350804233872635Matsuda YT, Miyamoto H, Joho RH, Hensch TKNeuroscience researchKv3.1 channels regulate the rate of critical period plasticity. Neurosci Res. 2021 Jun; 167:3-10.Neurosci Res2021-04-16T00:00:002021Kv3.1 channels regulate the rate of critical period plasticity.33878393Emoto K, Hensch TK, Yuzaki MNeuroscience research"Scrap & build" functional circuits: Molecular and cellular basis of neural remodeling. Neurosci Res. 2021 06; 167:1-2.Neurosci Res2021-04-18T00:00:002021"Scrap & build" functional circuits: Molecular and cellular basis of neural remodeling.Authorship 13873291034408277Benham RS, Choi C, Hodgson NW, Hewage NB, Kastli R, Donahue RJ, Muschamp JW, Engin E, Carlezon WA, Hensch TK, Rudolph UNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacologya2-containing ?-aminobutyric acid type A receptors promote stress resiliency in male mice. Neuropsychopharmacology. 2021 11; 46(12):2197-2206.Neuropsychopharmacology2021-08-18T00:00:002021a2-containing ?-aminobutyric acid type A receptors promote stress resiliency in male mice.Authorship 14060951034689167Zhu Y, Wang MJ, Crawford KM, Ramírez-Tapia JC, Lussier AA, Davis KA, de Leeuw C, Takesian AE, Hensch TK, Smoller JW, Dunn ECNeuropsychopharmacology : official publication of the American College of NeuropsychopharmacologySensitive period-regulating genetic pathways and exposure to adversity shape risk for depression. Neuropsychopharmacology. 2022 01; 47(2):497-506.Neuropsychopharmacology2021-10-23T00:00:002021Sensitive period-regulating genetic pathways and exposure to adversity shape risk for depression.Authorship 1417358434891424Sviridova N, Artoni P, Fagiolini M, Hensch TK, Aihara KAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International ConferenceDynamical Characteristics of Wild-Type Mouse Spontaneous Pupillary Fluctuations. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:853-856.Annu Int Conf IEEE Eng Med Biol Soc2021-11-01T00:00:002021Dynamical Characteristics of Wild-Type Mouse Spontaneous Pupillary Fluctuations.Authorship 2110722Authorship 1432130135120211Hensch TJournal of visionLifting brakes on visual cortical plasticity. J Vis. 2022 Feb 01; 22(3):49.J Vis2022-02-01T00:00:002022Lifting brakes on visual cortical plasticity.Authorship 1451107535535547Shonkoff JP, Boyce WT, Bush NR, Gunnar MR, Hensch TK, Levitt P, Meaney MJ, Nelson CA, Slopen N, Williams DR, Silveira PPPediatricsTranslating the Biology of Adversity and Resilience Into New Measures for Pediatric Practice. Pediatrics. 2022 06 01; 149(6).Pediatrics2022-06-01T00:00:002022Translating the Biology of Adversity and Resilience Into New Measures for Pediatric Practice.Authorship 4140222Authorship 1491563836130098Hameed MQ, Hodgson N, Lee HHC, Pascual-Leone A, MacMullin PC, Jannati A, Dhamne SC, Hensch TK, Rotenberg ACerebral cortex (New York, N.Y. : 1991)N-acetylcysteine treatment mitigates loss of cortical parvalbumin-positive interneuron and perineuronal net integrity resulting from persistent oxidative stress in a rat TBI model. Cereb Cortex. 2023 03 21; 33(7):4070-4084.Cereb Cortex2023-03-21T00:00:002023N-acetylcysteine treatment mitigates loss of cortical parvalbumin-positive interneuron and perineuronal net integrity resulting from persistent oxidative stress in a rat TBI model.Authorship 15124296Authorship 1513188736584108Cornelissen L, Underwood E, Gabard-Durnam LJ, Soto M, Tao A, Lobo K, Hensch TK, Berde CBPloS oneTactile sensitivity and motor coordination in infancy: Effect of age, prior surgery, anaesthesia & critical illness. PLoS One. 2022; 17(12):e0279705.PLoS One2022-12-30T00:00:002022Tactile sensitivity and motor coordination in infancy: Effect of age, prior surgery, anaesthesia & critical illness.36598942Quast KB, Reh RK, Caiati MD, Kopell N, McCarthy MM, Hensch TKProceedings of the National Academy of Sciences of the United States of AmericaRapid synaptic and gamma rhythm signature of mouse critical period plasticity. Proc Natl Acad Sci U S A. 2023 01 10; 120(2):e2123182120.Proc Natl Acad Sci U S A2023-01-04T00:00:002023Rapid synaptic and gamma rhythm signature of mouse critical period plasticity.Authorship 15541732Authorship 1572527537349338Wu C, Gaier ED, Nihalani BR, Whitecross S, Hensch TK, Hunter DGScientific reportsDurable recovery from amblyopia with donepezil. Sci Rep. 2023 06 22; 13(1):10161.Sci Rep2023-06-22T00:00:002023Durable recovery from amblyopia with donepezil.37432864Kanamaru T, Hensch TK, Aihara KNeural computationMaximal Memory Capacity Near the Edge of Chaos in Balanced Cortical E-I Networks. Neural Comput. 2023 Jun 20; 1-33.Neural Comput2023-06-20T00:00:002023Maximal Memory Capacity Near the Edge of Chaos in Balanced Cortical E-I Networks.true1Assistant Professor of Otolaryngology Head and Neck SurgeryAssistant Professor of Otolaryngology Head and Neck Surgerytrue1Professor of Otolaryngology Head and Neck SurgeryProfessor of Otolaryngology Head and Neck Surgerytrue1Bullard Professor of NeurobiologyBullard Professor of NeurobiologyAuthorship 50058612true1Research Associate in NeurologyResearch Associate in Neurology2Professor of Molecular and Cellular BiologyProfessor of Molecular and Cellular Biology3Tutor, Academic (Other Faculty)Tutor, Academic (Other Faculty)true1Professor of NeurologyProfessor of Neurologytrue1Alice and Rodman W. Moorhead III Professor of NeurobiologyAlice and Rodman W. Moorhead III Professor of Neurobiologytrue1Associate Professor of NeurologyAssociate Professor of Neurologytrue1Professor of NeurologyProfessor of Neurologytrue1Professor of NeurologyProfessor of Neurologytrue1Research Associate in NeurologyResearch Associate in NeurologyAuthorship 3426876Authorship 3658697Authorship 457674Authorship 6456886Authorship 6465841Authorship 651205623770240Spatazza J, Lee HH, Di Nardo AA, Tibaldi L, Joliot A, Hensch TK, Prochiantz ACell reportsChoroid-plexus-derived Otx2 homeoprotein constrains adult cortical plasticity. Cell Rep. 2013 Jun 27; 3(6):1815-23.Cell Rep2013-06-13T00:00:002013Choroid-plexus-derived Otx2 homeoprotein constrains adult cortical plasticity.23447797Hensch TK, Bilimoria PMCerebrum : the Dana forum on brain scienceRe-opening Windows: Manipulating Critical Periods for Brain Development. Cerebrum. 2012 Jul; 2012:11.Cerebrum2012-08-29T00:00:002012Re-opening Windows: Manipulating Critical Periods for Brain Development.23671099Cabungcal JH, Steullet P, Morishita H, Kraftsik R, Cuenod M, Hensch TK, Do KQProceedings of the National Academy of Sciences of the United States of AmericaPerineuronal nets protect fast-spiking interneurons against oxidative stress. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9130-5.Proc Natl Acad Sci U S A2013-05-13T00:00:002013Perineuronal nets protect fast-spiking interneurons against oxidative stress.Authorship 184263Authorship 6785651724030951Sanchez-Mut JV, Aso E, Panayotis N, Lott I, Dierssen M, Rabano A, Urdinguio RG, Fernandez AF, Astudillo A, Martin-Subero JI, Balint B, Fraga MF, Gomez A, Gurnot C, Roux JC, Avila J, Hensch TK, Ferrer I, Esteller MBrain : a journal of neurologyDNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease. Brain. 2013 Oct; 136(Pt 10):3018-27.Brain2013-09-11T00:00:002013DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease.Authorship 68041010Authorship 679339524094102Toyoizumi T, Miyamoto H, Yazaki-Sugiyama Y, Atapour N, Hensch TK, Miller KDNeuronA theory of the transition to critical period plasticity: inhibition selectively suppresses spontaneous activity. Neuron. 2013 Oct 02; 80(1):51-63.Neuron2013-10-02T00:00:002013A theory of the transition to critical period plasticity: inhibition selectively suppresses spontaneous activity.24109434Hisatsune C, Miyamoto H, Hirono M, Yamaguchi N, Sugawara T, Ogawa N, Ebisui E, Ohshima T, Yamada M, Hensch TK, Hattori M, Mikoshiba KFrontiers in neural circuitsIP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice. Front Neural Circuits. 2013; 7:156.Front Neural Circuits2013-10-04T00:00:002013IP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice.Authorship 681204224137112Kobayashi Y, Hensch TKFrontiers in neural circuitsGermline recombination by conditional gene targeting with Parvalbumin-Cre lines. Front Neural Circuits. 2013; 7:168.Front Neural Circuits2013-10-16T00:00:002013Germline recombination by conditional gene targeting with Parvalbumin-Cre lines.Authorship 6913549Authorship 6919682Authorship 691543424198369Kang E, Durand S, LeBlanc JJ, Hensch TK, Chen C, Fagiolini MThe Journal of neuroscience : the official journal of the Society for NeuroscienceVisual acuity development and plasticity in the absence of sensory experience. J Neurosci. 2013 Nov 06; 33(45):17789-96.J Neurosci2013-11-06T00:00:002013Visual acuity development and plasticity in the absence of sensory experience.24017432Bellinger FP, Hensch TKMicroscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of CanadaDifferential Distribution of NMDA and AMPA Receptor Activity in Layer II/III in Mouse Primary Visual Cortex. Microsc Microanal. 2005 Aug; 11 Suppl 2:1124-5.Microsc Microanal2005-08-01T00:00:002005Differential Distribution of NMDA and AMPA Receptor Activity in Layer II/III in Mouse Primary Visual Cortex.23922229Ogiwara I, Iwasato T, Miyamoto H, Iwata R, Yamagata T, Mazaki E, Yanagawa Y, Tamamaki N, Hensch TK, Itohara S, Yamakawa KHuman molecular geneticsNav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome. Hum Mol Genet. 2013 Dec 01; 22(23):4784-804.Hum Mol Genet2013-08-06T00:00:002013Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome.Authorship 695899224309249Takesian AE, Hensch TKProgress in brain researchBalancing plasticity/stability across brain development. Prog Brain Res. 2013; 207:3-34.Prog Brain Res2013-01-01T00:00:002013Balancing plasticity/stability across brain development.Authorship 698862524348349Gervain J, Vines BW, Chen LM, Seo RJ, Hensch TK, Werker JF, Young AHFrontiers in systems neuroscienceValproate reopens critical-period learning of absolute pitch. Front Syst Neurosci. 2013; 7:102.Front Syst Neurosci2013-12-03T00:00:002013Valproate reopens critical-period learning of absolute pitch.Authorship 704198124439367Hensch TKCellBistable parvalbumin circuits pivotal for brain plasticity. Cell. 2014 Jan 16; 156(1-2):17-9.Cell2014-01-16T00:00:002014Bistable parvalbumin circuits pivotal for brain plasticity.Authorship 638871Authorship 46303Authorship 709226417033630Brocke B, Armbruster D, Muller J, Hensch T, Jacob CP, Lesch KP, Kirschbaum C, Strobel AMolecular psychiatrySerotonin transporter gene variation impacts innate fear processing: Acoustic startle response and emotional startle. Mol Psychiatry. 2006 Dec; 11(12):1106-12.Mol Psychiatry2006-10-10T00:00:002006Serotonin transporter gene variation impacts innate fear processing: Acoustic startle response and emotional startle.Authorship 2803821Authorship 2833161Authorship 3318546Authorship 3495851Authorship 36402812Authorship 751459525088363Gogolla N, Takesian AE, Feng G, Fagiolini M, Hensch TKNeuronSensory integration in mouse insular cortex reflects GABA circuit maturation. Neuron. 2014 Aug 20; 83(4):894-905.Neuron2014-07-31T00:00:002014Sensory integration in mouse insular cortex reflects GABA circuit maturation.Authorship 764587522986304Ito S, Ogiwara I, Yamada K, Miyamoto H, Hensch TK, Osawa M, Yamakawa KNeurobiology of diseaseMouse with Nav1.1 haploinsufficiency, a model for Dravet syndrome, exhibits lowered sociability and learning impairment. Neurobiol Dis. 2013 Jan; 49:29-40.Neurobiol Dis2012-08-16T00:00:002012Mouse with Nav1.1 haploinsufficiency, a model for Dravet syndrome, exhibits lowered sociability and learning impairment.Authorship 777182225251488Werker JF, Hensch TKAnnual review of psychologyCritical periods in speech perception: new directions. Annu Rev Psychol. 2015 Jan 03; 66:173-96.Annu Rev Psychol2014-09-17T00:00:002014Critical periods in speech perception: new directions.Authorship 5746449Authorship 2703661Authorship 379572Authorship 3650545Authorship 4710061Authorship 4234485Authorship 1937863Authorship 5031661Authorship 2476443Authorship 1836474Authorship 2973873Authorship 42660611Authorship 3824737Authorship 2634122Authorship 3494186Authorship 3233114Authorship 4444072Authorship 5144174Authorship 78842615Authorship 80119211Authorship 796693325891251Gurnot C, Martin-Subero I, Mah SM, Weikum W, Goodman SJ, Brain U, Werker JF, Kobor MS, Esteller M, Oberlander TF, Hensch TKEpigeneticsPrenatal antidepressant exposure associated with CYP2E1 DNA methylation change in neonates. Epigenetics. 2015; 10(5):361-72.Epigenetics2015-04-18T00:00:002015Prenatal antidepressant exposure associated with CYP2E1 DNA methylation change in neonates.25022540Albers MW, Gilmore GC, Kaye J, Murphy C, Wingfield A, Bennett DA, Boxer AL, Buchman AS, Cruickshanks KJ, Devanand DP, Duffy CJ, Gall CM, Gates GA, Granholm AC, Hensch T, Holtzer R, Hyman BT, Lin FR, McKee AC, Morris JC, Petersen RC, Silbert LC, Struble RG, Trojanowski JQ, Verghese J, Wilson DA, Xu S, Zhang LIAlzheimer's & dementia : the journal of the Alzheimer's AssociationAt the interface of sensory and motor dysfunctions and Alzheimer's disease. Alzheimers Dement. 2015 Jan; 11(1):70-98.Alzheimers Dement2014-07-09T00:00:002014At the interface of sensory and motor dysfunctions and Alzheimer's disease.25801703Kobayashi Y, Ye Z, Hensch TKNeuronClock genes control cortical critical period timing. Neuron. 2015 Apr 08; 86(1):264-75.Neuron2015-03-19T00:00:002015Clock genes control cortical critical period timing.Authorship 4432596Authorship 4125414Authorship 812204326032508Do KQ, Cuenod M, Hensch TKSchizophrenia bulletinTargeting Oxidative Stress and Aberrant Critical Period Plasticity in the Developmental Trajectory to Schizophrenia. Schizophr Bull. 2015 Jul; 41(4):835-46.Schizophr Bull2015-06-01T00:00:002015Targeting Oxidative Stress and Aberrant Critical Period Plasticity in the Developmental Trajectory to Schizophrenia.Authorship 4665813Authorship 829836525758057Morishita H, Cabungcal JH, Chen Y, Do KQ, Hensch TKBiological psychiatryProlonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons. Biol Psychiatry. 2015 Sep 15; 78(6):396-402.Biol Psychiatry2015-01-24T00:00:002015Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons.Authorship 65576726539889Ye Z, Mostajo-Radji MA, Brown JR, Rouaux C, Tomassy GS, Hensch TK, Arlotta PNeuronInstructing Perisomatic Inhibition by Direct Lineage Reprogramming of Neocortical Projection Neurons. Neuron. 2015 Nov 04; 88(3):475-83.Neuron2015-11-04T00:00:002015Instructing Perisomatic Inhibition by Direct Lineage Reprogramming of Neocortical Projection Neurons.Authorship 8432516Authorship 848395426609151Takei Y, Kikkawa YS, Atapour N, Hensch TK, Hirokawa NThe Journal of neuroscience : the official journal of the Society for NeuroscienceDefects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A. J Neurosci. 2015 Nov 25; 35(47):15539-54.J Neurosci2015-11-25T00:00:002015Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A.Authorship 8529761026673794Lennartsson A, Arner E, Fagiolini M, Saxena A, Andersson R, Takahashi H, Noro Y, Sng J, Sandelin A, Hensch TK, Carninci PEpigenetics & chromatinRemodeling of retrotransposon elements during epigenetic induction of adult visual cortical plasticity by HDAC inhibitors. Epigenetics Chromatin. 2015; 8:55.Epigenetics Chromatin2015-12-14T00:00:002015Remodeling of retrotransposon elements during epigenetic induction of adult visual cortical plasticity by HDAC inhibitors.26771493Bei F, Lee HHC, Liu X, Gunner G, Jin H, Ma L, Wang C, Hou L, Hensch TK, Frank E, Sanes JR, Chen C, Fagiolini M, He ZCellRestoration of Visual Function by Enhancing Conduction in Regenerated Axons. Cell. 2016 Jan 14; 164(1-2):219-232.Cell2016-01-14T00:00:002016Restoration of Visual Function by Enhancing Conduction in Regenerated Axons.Authorship 5323374Authorship 8577269Authorship 816862Authorship 870016126930830Hensch TKScientific AmericanTHE POWER OF THE INFANT BRAIN. Sci Am. 2016 Feb; 314(2):64-9.Sci Am2016-02-01T00:00:002016THE POWER OF THE INFANT BRAIN.Authorship 876654326185009Mierau SB, Patrizi A, Hensch TK, Fagiolini MBiological psychiatryCell-Specific Regulation of N-Methyl-D-Aspartate Receptor Maturation by Mecp2 in Cortical Circuits. Biol Psychiatry. 2016 May 01; 79(9):746-754.Biol Psychiatry2015-06-05T00:00:002015Cell-Specific Regulation of N-Methyl-D-Aspartate Receptor Maturation by Mecp2 in Cortical Circuits.Authorship 4088094Authorship 5126083Authorship 5824882Assistant Professor1Associate Professor0Full Professor5Other FacultyAuthorship 5537273Authorship 5758721GJF11GordFishellGord Fishell, Ph.D.152093Fishell, GordProfessor of Neurobiology2018-11-30JENSEN, FRANCES E2013-08-01Early Life Seizures Disrupt Critical Period PlasticityR01NS0805652012-07-31HENSCH, TAKAO K2007-09-30Dissecting Non-coding RNA Function in Critical Period Brain Development and DisorDP1OD0036992014-03-31HENSCH, TAKAO K2012-04-01Activity-dependent modification of electrical synapse strengthR03NS0757222024-03-31HENSCH, TAKAO K2011-09-05Developmental origins of mental illness: evolution and reversibilityP50MH094271Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorAuthorship 805562Authorship 3477131Authorship 38822058Authorship 20967639Authorship 347390827909008Hsieh TH, Lee HHC, Hameed MQ, Pascual-Leone A, Hensch TK, Rotenberg ACerebral cortex (New York, N.Y. : 1991)Trajectory of Parvalbumin Cell Impairment and Loss of Cortical Inhibition in Traumatic Brain Injury. Cereb Cortex. 2017 12 01; 27(12):5509-5524.Cereb Cortex2017-12-01T00:00:002017Trajectory of Parvalbumin Cell Impairment and Loss of Cortical Inhibition in Traumatic Brain Injury.Authorship 957532828194008Lee HHC, Bernard C, Ye Z, Acampora D, Simeone A, Prochiantz A, Di Nardo AA, Hensch TKMolecular psychiatryGenetic Otx2 mis-localization delays critical period plasticity across brain regions. Mol Psychiatry. 2017 05; 22(5):680-688.Mol Psychiatry2017-02-14T00:00:002017Genetic Otx2 mis-localization delays critical period plasticity across brain regions.8871213Artola A, Hensch T, Singer WJournal of neurophysiologyCalcium-induced long-term depression in the visual cortex of the rat in vitro. J Neurophysiol. 1996 Aug; 76(2):984-94.J Neurophysiol1996-08-01T00:00:001996Calcium-induced long-term depression in the visual cortex of the rat in vitro.12032349Mataga N, Nagai N, Hensch TKProceedings of the National Academy of Sciences of the United States of AmericaPermissive proteolytic activity for visual cortical plasticity. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7717-21.Proc Natl Acad Sci U S A2002-05-28T00:00:002002Permissive proteolytic activity for visual cortical plasticity.10724170Fagiolini M, Hensch TKNatureInhibitory threshold for critical-period activation in primary visual cortex. Nature. 2000 Mar 09; 404(6774):183-6.Nature2000-03-09T00:00:002000Inhibitory threshold for critical-period activation in primary visual cortex.Authorship 959614515017002Fagiolini M, Fritschy JM, Löw K, Möhler H, Rudolph U, Hensch TKScience (New York, N.Y.)Specific GABAA circuits for visual cortical plasticity. Science. 2004 Mar 12; 303(5664):1681-3.Science2004-03-12T00:00:002004Specific GABAA circuits for visual cortical plasticity.15603745Mataga N, Mizuguchi Y, Hensch TKNeuronExperience-dependent pruning of dendritic spines in visual cortex by tissue plasminogen activator. Neuron. 2004 Dec 16; 44(6):1031-41.Neuron2004-12-16T00:00:002004Experience-dependent pruning of dendritic spines in visual cortex by tissue plasminogen activator.9482797Hensch TK, Gordon JA, Brandon EP, McKnight GS, Idzerda RL, Stryker MPThe Journal of neuroscience : the official journal of the Society for NeuroscienceComparison of plasticity in vivo and in vitro in the developing visual cortex of normal and protein kinase A RIbeta-deficient mice. J Neurosci. 1998 Mar 15; 18(6):2108-17.J Neurosci1998-03-15T00:00:001998Comparison of plasticity in vivo and in vitro in the developing visual cortex of normal and protein kinase A RIbeta-deficient mice.17359916Katagiri H, Fagiolini M, Hensch TKNeuronOptimization of somatic inhibition at critical period onset in mouse visual cortex. Neuron. 2007 Mar 15; 53(6):805-12.Neuron2007-03-15T00:00:002007Optimization of somatic inhibition at critical period onset in mouse visual cortex.Authorship 973187728322275Steullet P, Cabungcal JH, Coyle J, Didriksen M, Gill K, Grace AA, Hensch TK, LaMantia AS, Lindemann L, Maynard TM, Meyer U, Morishita H, O'Donnell P, Puhl M, Cuenod M, Do KQMolecular psychiatryOxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia. Mol Psychiatry. 2017 07; 22(7):936-943.Mol Psychiatry2017-03-21T00:00:002017Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia.Authorship 975311828373687Lee HHC, Bernard C, Ye Z, Acampora D, Simeone A, Prochiantz A, Di Nardo AA, Hensch TKMolecular psychiatryGenetic Otx2 mis-localization delays critical period plasticity across brain regions. Mol Psychiatry. 2017 05; 22(5):785.Mol Psychiatry2017-04-04T00:00:002017Genetic Otx2 mis-localization delays critical period plasticity across brain regions.15217343Hensch TKAnnual review of neuroscienceCritical period regulation. Annu Rev Neurosci. 2004; 27:549-79.Annu Rev Neurosci2004-01-01T00:00:002004Critical period regulation.16340957Illes J, Blakemore C, Hansson MG, Hensch TK, Leshner A, Maestre G, Magistretti P, Quirion R, Strata PNature reviews. NeuroscienceInternational perspectives on engaging the public in neuroethics. Nat Rev Neurosci. 2005 Dec; 6(12):977-82.Nat Rev Neurosci2005-12-01T00:00:002005International perspectives on engaging the public in neuroethics.12890762Iwai Y, Fagiolini M, Obata K, Hensch TKThe Journal of neuroscience : the official journal of the Society for NeuroscienceRapid critical period induction by tonic inhibition in visual cortex. J Neurosci. 2003 Jul 30; 23(17):6695-702.J Neurosci2003-07-30T00:00:002003Rapid critical period induction by tonic inhibition in visual cortex.15017001Hensch TK, Stryker MPScience (New York, N.Y.)Columnar architecture sculpted by GABA circuits in developing cat visual cortex. Science. 2004 Mar 12; 303(5664):1678-81.Science2004-03-12T00:00:002004Columnar architecture sculpted by GABA circuits in developing cat visual cortex.21068299Bavelier D, Levi DM, Li RW, Dan Y, Hensch TKThe Journal of neuroscience : the official journal of the Society for NeuroscienceRemoving brakes on adult brain plasticity: from molecular to behavioral interventions. J Neurosci. 2010 Nov 10; 30(45):14964-71.J Neurosci2010-11-10T00:00:002010Removing brakes on adult brain plasticity: from molecular to behavioral interventions.22415912Maurer D, Hensch TKDevelopmental psychobiologyAmblyopia: background to the special issue on stroke recovery. Dev Psychobiol. 2012 Apr; 54(3):224-38.Dev Psychobiol2012-04-01T00:00:002012Amblyopia: background to the special issue on stroke recovery.12754515Miyamoto H, Katagiri H, Hensch TNature neuroscienceExperience-dependent slow-wave sleep development. Nat Neurosci. 2003 Jun; 6(6):553-4.Nat Neurosci2003-06-01T00:00:002003Experience-dependent slow-wave sleep development.16243601Hensch TKCurrent topics in developmental biologyCritical period mechanisms in developing visual cortex. Curr Top Dev Biol. 2005; 69:215-37.Curr Top Dev Biol2005-01-01T00:00:002005Critical period mechanisms in developing visual cortex.21071629Morishita H, Miwa JM, Heintz N, Hensch TKScience (New York, N.Y.)Lynx1, a cholinergic brake, limits plasticity in adult visual cortex. Science. 2010 Nov 26; 330(6008):1238-40.Science2010-11-11T00:00:002010Lynx1, a cholinergic brake, limits plasticity in adult visual cortex.18692473Sugiyama S, Di Nardo AA, Aizawa S, Matsuo I, Volovitch M, Prochiantz A, Hensch TKCellExperience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity. Cell. 2008 Aug 08; 134(3):508-20.Cell2008-08-08T00:00:002008Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity.19298552Sugiyama S, Prochiantz A, Hensch TKDevelopment, growth & differentiationFrom brain formation to plasticity: insights on Otx2 homeoprotein. Dev Growth Differ. 2009 Apr; 51(3):369-77.Dev Growth Differ2009-02-27T00:00:002009From brain formation to plasticity: insights on Otx2 homeoprotein.12819125Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T, Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA, Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts P, Muramatsu M, Okazaki Y, Kawai J, Hayashizaki YGenome researchTargeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Genome Res. 2003 Jun; 13(6B):1273-89.Genome Res2003-06-01T00:00:002003Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.23259945Durand S, Patrizi A, Quast KB, Hachigian L, Pavlyuk R, Saxena A, Carninci P, Hensch TK, Fagiolini MNeuronNMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2. Neuron. 2012 Dec 20; 76(6):1078-90.Neuron2012-12-20T00:00:002012NMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2.20664807Gogolla N, Leblanc JJ, Quast KB, Südhof TC, Fagiolini M, Hensch TKJournal of neurodevelopmental disordersCommon circuit defect of excitatory-inhibitory balance in mouse models of autism. J Neurodev Disord. 2009 Jun; 1(2):172-81.J Neurodev Disord2009-07-11T00:00:002009Common circuit defect of excitatory-inhibitory balance in mouse models of autism.22764251Beurdeley M, Spatazza J, Lee HH, Sugiyama S, Bernard C, Di Nardo AA, Hensch TK, Prochiantz AThe Journal of neuroscience : the official journal of the Society for NeuroscienceOtx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex. J Neurosci. 2012 Jul 04; 32(27):9429-37.J Neurosci2012-07-04T00:00:002012Otx2 binding to perineuronal nets persistently regulates plasticity in the mature visual cortex.Authorship 10167733Authorship 1016392111927383Nagao S, Yoshioka N, Hensch T, Hasegawa I, Nakamura N, Nagao Y, Ito MActa oto-laryngologica. SupplementumThe role of cerebellar flocculus in adaptive gain control of ocular reflexes. Acta Otolaryngol Suppl. 1991; 481:234-6.Acta Otolaryngol Suppl1991-01-01T00:00:001991The role of cerebellar flocculus in adaptive gain control of ocular reflexes.28974755Hou X, Yoshioka N, Tsukano H, Sakai A, Miyata S, Watanabe Y, Yanagawa Y, Sakimura K, Takeuchi K, Kitagawa H, Hensch TK, Shibuki K, Igarashi M, Sugiyama SScientific reportsChondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex. Sci Rep. 2017 10 03; 7(1):12646.Sci Rep2017-10-03T00:00:002017Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex.14513556Hirozane-Kishikawa T, Shiraki T, Waki K, Nakamura M, Arakawa T, Kawai J, Fagiolini M, Hensch TK, Hayashizaki Y, Carninci PBioTechniquesSubtraction of cap-trapped full-length cDNA libraries to select rare transcripts. Biotechniques. 2003 Sep; 35(3):510-6, 518.Biotechniques2003-09-01T00:00:002003Subtraction of cap-trapped full-length cDNA libraries to select rare transcripts.11805343Renger JJ, Hartman KN, Tsuchimoto Y, Yokoi M, Nakanishi S, Hensch TKProceedings of the National Academy of Sciences of the United States of AmericaExperience-dependent plasticity without long-term depression by type 2 metabotropic glutamate receptors in developing visual cortex. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):1041-6.Proc Natl Acad Sci U S A2002-01-22T00:00:002002Experience-dependent plasticity without long-term depression by type 2 metabotropic glutamate receptors in developing visual cortex.1684239Ajima A, Hensch T, Kado RT, Ito MNeuroscience researchDifferential blocking action of Joro spider toxin analog on parallel fiber and climbing fiber synapses in cerebellar Purkinje cells. Neurosci Res. 1991 Oct; 12(1):281-6.Neurosci Res1991-10-01T00:00:001991Differential blocking action of Joro spider toxin analog on parallel fiber and climbing fiber synapses in cerebellar Purkinje cells.16261181Hensch TKNature reviews. NeuroscienceCritical period plasticity in local cortical circuits. Nat Rev Neurosci. 2005 Nov; 6(11):877-88.Nat Rev Neurosci2005-11-01T00:00:002005Critical period plasticity in local cortical circuits.21804538Barkat TR, Polley DB, Hensch TKNature neuroscienceA critical period for auditory thalamocortical connectivity. Nat Neurosci. 2011 Jul 31; 14(9):1189-94.Nat Neurosci2011-07-31T00:00:002011A critical period for auditory thalamocortical connectivity.AT309AnneTakesianAnne Takesian, Ph.D.164737Takesian, AnneAssistant Professor of Otolaryngology Head and Neck SurgeryAuthorship 1024974429118206Cameron JL, Eagleson KL, Fox NA, Hensch TK, Levitt PThe Journal of neuroscience : the official journal of the Society for NeuroscienceSocial Origins of Developmental Risk for Mental and Physical Illness. J Neurosci. 2017 11 08; 37(45):10783-10791.J Neurosci2017-11-08T00:00:002017Social Origins of Developmental Risk for Mental and Physical Illness.8614806Hensch TK, Stryker MPScience (New York, N.Y.)Ocular dominance plasticity under metabotropic glutamate receptor blockade. Science. 1996 Apr 26; 272(5261):554-7.Science1996-04-26T00:00:001996Ocular dominance plasticity under metabotropic glutamate receptor blockade.23045690Yang EJ, Lin EW, Hensch TKProceedings of the National Academy of Sciences of the United States of AmericaCritical period for acoustic preference in mice. Proc Natl Acad Sci U S A. 2012 Oct 16; 109 Suppl 2:17213-20.Proc Natl Acad Sci U S A2012-10-08T00:00:002012Critical period for acoustic preference in mice.18534841Morishita H, Hensch TKCurrent opinion in neurobiologyCritical period revisited: impact on vision. Curr Opin Neurobiol. 2008 Feb; 18(1):101-7.Curr Opin Neurobiol2008-06-03T00:00:002008Critical period revisited: impact on vision.52 Oxford StreetCenter for Brain Science (NW347.10)Northwest Lab Building52 Oxford StreetCambridge02138MA18039590Hensch T, Herold U, Diers K, Armbruster D, Brocke BClinical neurophysiology : official journal of the International Federation of Clinical NeurophysiologyReliability of intensity dependence of auditory-evoked potentials. Clin Neurophysiol. 2008 Jan; 119(1):224-36.Clin Neurophysiol2007-11-26T00:00:002007Reliability of intensity dependence of auditory-evoked potentials.21338885Lodato S, Rouaux C, Quast KB, Jantrachotechatchawan C, Studer M, Hensch TK, Arlotta PNeuronExcitatory projection neuron subtypes control the distribution of local inhibitory interneurons in the cerebral cortex. Neuron. 2011 Feb 24; 69(4):763-79.Neuron2011-02-24T00:00:002011Excitatory projection neuron subtypes control the distribution of local inhibitory interneurons in the cerebral cortex.17537961Ogiwara I, Miyamoto H, Morita N, Atapour N, Mazaki E, Inoue I, Takeuchi T, Itohara S, Yanagawa Y, Obata K, Furuichi T, Hensch TK, Yamakawa KThe Journal of neuroscience : the official journal of the Society for NeuroscienceNav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. J Neurosci. 2007 May 30; 27(22):5903-14.J Neurosci2007-05-30T00:00:002007Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.18714383Plessy C, Fagiolini M, Wagatsuma A, Harasawa N, Kuji T, Asaka-Oba A, Kanzaki Y, Fujishima S, Waki K, Nakahara H, Hensch TK, Carninci PPloS oneA resource for transcriptomic analysis in the mouse brain. PLoS One. 2008 Aug 20; 3(8):e3012.PLoS One2008-08-20T00:00:002008A resource for transcriptomic analysis in the mouse brain.19147686Suzuki T, Miyamoto H, Nakahari T, Inoue I, Suemoto T, Jiang B, Hirota Y, Itohara S, Saido TC, Tsumoto T, Sawamoto K, Hensch TK, Delgado-Escueta AV, Yamakawa KHuman molecular geneticsEfhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility. 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