Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundbäck P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Ting JP, Wang H, Andersson U, Antoine DJ, Chavan SS, Hotamisligil GS, Tracey KJ
Novel role of PKR in inflammasome activation and HMGB1 release. Nature. 2012 Aug 30; 488(7413):670-4.
Novel role of PKR in inflammasome activation and HMGB1 release.
Liu L, Inouye KE, Allman WR, Coleman AS, Siddiqui S, Hotamisligil GS, Akkoyunlu M
TACI-Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis. Diabetes. 2018 08; 67(8):1589-1603.
TACI-Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis.
Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS
TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest. 2006 Nov; 116(11):3015-25.
TLR4 links innate immunity and fatty acid-induced insulin resistance.
Inouye KE, Yue JT, Chan O, Kim T, Akirav EM, Park E, Riddell MC, Burdett E, Matthews SG, Vranic M
Effects of insulin treatment without and with recurrent hypoglycemia on hypoglycemic counterregulation and adrenal catecholamine-synthesizing enzymes in diabetic rats. Endocrinology. 2006 Apr; 147(4):1860-70.
Effects of insulin treatment without and with recurrent hypoglycemia on hypoglycemic counterregulation and adrenal catecholamine-synthesizing enzymes in diabetic rats.
Tirosh A, Calay ES, Tuncman G, Claiborn KC, Inouye KE, Eguchi K, Alcala M, Rathaus M, Hollander KS, Ron I, Livne R, Heianza Y, Qi L, Shai I, Garg R, Hotamisligil GS
The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans. Sci Transl Med. 2019 04 24; 11(489).
The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans.
Harvard T.H. Chan School of Public Health
Barry R. and Irene T. Bloom Professorship of Public Health
Cecil K. and Philip Drinker Professor of Environmental Physiology
James Stevens Simmons Professor of Genetics and Metabolism
Stanley J. Korsmeyer Professor of Cell Biology and Medicine
Harvard University Distinguished Service Professor
Liu CL, Ren J, Wang Y, Zhang X, Sukhova GK, Liao M, Santos M, Luo S, Yang D, Xia M, Inouye K, Hotamisligil GS, Lu G, Upchurch GR, Libby P, Guo J, Zhang J, Shi GP
Adipocytes promote interleukin-18 binding to its receptors during abdominal aortic aneurysm formation in mice. Eur Heart J. 2020 07 07; 41(26):2456-2468.
Adipocytes promote interleukin-18 binding to its receptors during abdominal aortic aneurysm formation in mice.
Shum K, Inouye K, Chan O, Mathoo J, Bilinski D, Matthews SG, Vranic M
American journal of physiology. Endocrinology and metabolism
Effects of antecedent hypoglycemia, hyperinsulinemia, and excess corticosterone on hypoglycemic counterregulation. Am J Physiol Endocrinol Metab. 2001 Sep; 281(3):E455-65.
Effects of antecedent hypoglycemia, hyperinsulinemia, and excess corticosterone on hypoglycemic counterregulation.
Inouye K, Chan O, Riddell MC, Akirav E, Matthews SG, Vranic M
Mechanisms of impaired hypothalamic-pituitary-adrenal (HPA) function in diabetes: reduced counterregulatory responsiveness to hypoglycaemia. Diabetes Nutr Metab. 2002 Oct; 15(5):348-55; discussion 355-6, 362.
Mechanisms of impaired hypothalamic-pituitary-adrenal (HPA) function in diabetes: reduced counterregulatory responsiveness to hypoglycaemia.
Chan O, Chan S, Inouye K, Vranic M, Matthews SG
Molecular regulation of the hypothalamo-pituitary-adrenal axis in streptozotocin-induced diabetes: effects of insulin treatment. Endocrinology. 2001 Nov; 142(11):4872-9.
Molecular regulation of the hypothalamo-pituitary-adrenal axis in streptozotocin-induced diabetes: effects of insulin treatment.
Chan O, Inouye K, Riddell MC, Vranic M, Matthews SG
Diabetes and the hypothalamo-pituitary-adrenal (HPA) axis. Minerva Endocrinol. 2003 Jun; 28(2):87-102.
Diabetes and the hypothalamo-pituitary-adrenal (HPA) axis.
Prentice KJ, Saksi J, Robertson LT, Lee GY, Inouye KE, Eguchi K, Lee A, Cakici O, Otterbeck E, Cedillo P, Achenbach P, Ziegler AG, Calay ES, Engin F, Hotamisligil GS
A hormone complex of FABP4 and nucleoside kinases regulates islet function. Nature. 2021 12; 600(7890):720-726.
A hormone complex of FABP4 and nucleoside kinases regulates islet function.
Guney E, Arruda AP, Parlakgul G, Cagampan E, Min N, Lee GY, Greene L, Tsaousidou E, Inouye K, Han MS, Davis RJ, Hotamisligil GS
Aberrant Ca2+ signaling by IP3Rs in adipocytes links inflammation to metabolic dysregulation in obesity. Sci Signal. 2021 Dec 14; 14(713):eabf2059.
Aberrant Ca2+ signaling by IP3Rs in adipocytes links inflammation to metabolic dysregulation in obesity.
Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamisligil GS
Regulation of liver subcellular architecture controls metabolic homeostasis. Nature. 2022 03; 603(7902):736-742.
Regulation of liver subcellular architecture controls metabolic homeostasis.
Goncalves RLS, Wang ZB, Inouye KE, Lee GY, Fu X, Saksi J, Rosique C, Parlakgul G, Arruda AP, Hui ST, Loperena MC, Burgess SC, Graupera I, Hotamisligil GS
bioRxiv : the preprint server for biology
Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity. bioRxiv. 2023 Feb 22.
Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity.
Prentice KJ, Lee A, Cedillo P, Inouye KE, Ertunc ME, Riveros JK, Lee GY, Hotamisligil GS
Sympathetic tone dictates the impact of lipolysis on FABP4 secretion. J Lipid Res. 2023 06; 64(6):100386.
Sympathetic tone dictates the impact of lipolysis on FABP4 secretion.
Inouye KE, Prentice KJ, Lee A, Wang ZB, Dominguez-Gonzalez C, Chen MX, Riveros JK, Burak MF, Lee GY, Hotamisligil GS
Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion. JCI Insight. 2023 07 24; 8(14).
Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion.
Yuan B, Doxsey W, Tok Ö, Kwon YY, Inouye KE, Hotamisligil GS, Hui S
An Organism-Level Quantitative Flux Model of Energy Metabolism in Mice. bioRxiv. 2024 Jul 24.
An Organism-Level Quantitative Flux Model of Energy Metabolism in Mice.
Burak MF, Tuncman G, Ayci AN, Chetal K, Seropian GYL, Inouye K, Lai ZW, Dagtekin N, Sadreyev RI, Israel E, Hotamisligil GS
An Adipo-Pulmonary Axis Mediated by FABP4 Hormone Defines a Therapeutic Target Against Obesity-Induced Airway Disease. bioRxiv. 2024 Jul 18.
An Adipo-Pulmonary Axis Mediated by FABP4 Hormone Defines a Therapeutic Target Against Obesity-Induced Airway Disease.
Gregor MF, Misch ES, Yang L, Hummasti S, Inouye KE, Lee AH, Bierie B, Hotamisligil GS
The role of adipocyte XBP1 in metabolic regulation during lactation. Cell Rep. 2013 May 30; 3(5):1430-9.
The role of adipocyte XBP1 in metabolic regulation during lactation.
Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A, Inouye K, Rickey LM, Ercal BC, Furuhashi M, Tuncman G, Hotamisligil GS
Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. Cell Metab. 2013 May 07; 17(5):768-78.
Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production.
Liu S, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelian A, Plutzky J, Lee CH
A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature. 2013 Oct 24; 502(7472):550-4.
A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use.
Yuan B, Doxsey W, Tok Ö, Kwon YY, Liang Y, Inouye KE, Hotamisligil GS, Hui S
An organism-level quantitative flux model of energy metabolism in mice. Cell Metab. 2025 Apr 01; 37(4):1012-1023.e6.
An organism-level quantitative flux model of energy metabolism in mice.
Kalafut KC, Cormerais Y, Cissé MY, Lapp SC, Inouye KE, Hotamisligil GS, Manning BD
Dietary protein governs the role of insulin signaling in the postprandial regulation of hepatic mTORC1. bioRxiv. 2025 Oct 03.
Dietary protein governs the role of insulin signaling in the postprandial regulation of hepatic mTORC1.
Director of the Sabri Ulker Center's Physiology Lab
Arruda AP, Pers BM, Parlakgül G, Güney E, Inouye K, Hotamisligil GS
Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity. Nat Med. 2014 Dec; 20(12):1427-35.
Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity.
Lee YJ, Liu C, Liao M, Sukhova GK, Shirakawa J, Abdennour M, Iamarene K, Andre S, Inouye K, Clement K, Kulkarni RN, Banks AS, Libby P, Shi GP
Deficiency of Fc?R1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice. Endocrinology. 2015 Nov; 156(11):4047-58.
Deficiency of Fc?R1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice.
Burak MF, Inouye KE, White A, Lee A, Tuncman G, Calay ES, Sekiya M, Tirosh A, Eguchi K, Birrane G, Lightwood D, Howells L, Odede G, Hailu H, West S, Garlish R, Neale H, Doyle C, Moore A, Hotamisligil GS
Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. Sci Transl Med. 2015 Dec 23; 7(319):319ra205.
Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.
Inouye KE, Chan O, Yue JT, Matthews SG, Vranic M
Effects of diabetes and recurrent hypoglycemia on the regulation of the sympathoadrenal system and hypothalamo-pituitary-adrenal axis. Am J Physiol Endocrinol Metab. 2005 Feb; 288(2):E422-9.
Effects of diabetes and recurrent hypoglycemia on the regulation of the sympathoadrenal system and hypothalamo-pituitary-adrenal axis.
Chan O, Inouye K, Akirav EM, Park E, Riddell MC, Matthews SG, Vranic M
American journal of physiology. Regulatory, integrative and comparative physiology
Hyperglycemia does not increase basal hypothalamo-pituitary-adrenal activity in diabetes but it does impair the HPA response to insulin-induced hypoglycemia. Am J Physiol Regul Integr Comp Physiol. 2005 Jul; 289(1):R235-46.
Hyperglycemia does not increase basal hypothalamo-pituitary-adrenal activity in diabetes but it does impair the HPA response to insulin-induced hypoglycemia.
Inouye K, Shum K, Chan O, Mathoo J, Matthews SG, Vranic M
Effects of recurrent hyperinsulinemia with and without hypoglycemia on counterregulation in diabetic rats. Am J Physiol Endocrinol Metab. 2002 Jun; 282(6):E1369-79.
Effects of recurrent hyperinsulinemia with and without hypoglycemia on counterregulation in diabetic rats.
Chan O, Chan S, Inouye K, Shum K, Matthews SG, Vranic M
Diabetes impairs hypothalamo-pituitary-adrenal (HPA) responses to hypoglycemia, and insulin treatment normalizes HPA but not epinephrine responses. Diabetes. 2002 Jun; 51(6):1681-9.
Diabetes impairs hypothalamo-pituitary-adrenal (HPA) responses to hypoglycemia, and insulin treatment normalizes HPA but not epinephrine responses.
Chan O, Inouye K, Akirav E, Park E, Riddell MC, Vranic M, Matthews SG
Insulin alone increases hypothalamo-pituitary-adrenal activity, and diabetes lowers peak stress responses. Endocrinology. 2005 Mar; 146(3):1382-90.
Insulin alone increases hypothalamo-pituitary-adrenal activity, and diabetes lowers peak stress responses.
Hyperactivation of the hypothalamo-pituitary-adrenocortical axis in streptozotocin-diabetes is associated with reduced stress responsiveness and decreased pituitary and adrenal sensitivity. Endocrinology. 2002 May; 143(5):1761-8.
Hyperactivation of the hypothalamo-pituitary-adrenocortical axis in streptozotocin-diabetes is associated with reduced stress responsiveness and decreased pituitary and adrenal sensitivity.
Inouye KE, Chan O, Yue JT, Andrews M, Li Q, Matthews SG, Vranic M
The effect of long-term insulin treatment with and without antecedent hypoglycemia on neuropeptide and corticosteroid receptor expression in the brains of diabetic rats. Brain Res Bull. 2008 Oct 22; 77(4):149-57.
The effect of long-term insulin treatment with and without antecedent hypoglycemia on neuropeptide and corticosteroid receptor expression in the brains of diabetic rats.
Shi H, Cave B, Inouye K, Bjørbaek C, Flier JS
Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance. Diabetes. 2006 Mar; 55(3):699-707.
Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance.
Inouye KE, Shi H, Howard JK, Daly CH, Lord GM, Rollins BJ, Flier JS
Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes. 2007 Sep; 56(9):2242-50.
Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue.
Brace LE, Vose SC, Stanya K, Gathungu RM, Marur VR, Longchamp A, Treviño-Villarreal H, Mejia P, Vargas D, Inouye K, Bronson RT, Lee CH, Neilan E, Kristal BS, Mitchell JR
Increased oxidative phosphorylation in response to acute and chronic DNA damage. NPJ Aging Mech Dis. 2016; 2:16022.
Increased oxidative phosphorylation in response to acute and chronic DNA damage.
Charles KN, Li MD, Engin F, Arruda AP, Inouye K, Hotamisligil GS
Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins. Cell Rep. 2017 Oct 10; 21(2):393-402.
Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins.
Stanya KJ, Jacobi D, Liu S, Bhargava P, Dai L, Gangl MR, Inouye K, Barlow JL, Ji Y, Mizgerd JP, Qi L, Shi H, McKenzie AN, Lee CH
Direct control of hepatic glucose production by interleukin-13 in mice. J Clin Invest. 2013 Jan; 123(1):261-71.
Direct control of hepatic glucose production by interleukin-13 in mice.
Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity. Nat Med. 2018 03; 24(3):292-303.
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.
Akirav EM, Chan O, Inouye K, Riddell MC, Matthews SG, Vranic M
Partial leptin restoration increases hypothalamic-pituitary-adrenal activity while diminishing weight loss and hyperphagia in streptozotocin diabetic rats. Metabolism. 2004 Dec; 53(12):1558-64.
Partial leptin restoration increases hypothalamic-pituitary-adrenal activity while diminishing weight loss and hyperphagia in streptozotocin diabetic rats.