DCS3DennisSgroiDennis Charles Sgroi, M.D.42.37730000000000-71.0525000000000025340Sgroi, DennisCharles617/726-2967Professor of Pathologycatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson11301010Cantor SB, Bell DW, Ganesan S, Kass EM, Drapkin R, Grossman S, Wahrer DC, Sgroi DC, Lane WS, Haber DA, Livingston DMCellBACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell. 2001 Apr 06; 105(1):149-60.Cell2001-04-06T00:00:002001BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.11479200Porter DA, Krop IE, Nasser S, Sgroi D, Kaelin CM, Marks JR, Riggins G, Polyak KCancer researchA SAGE (serial analysis of gene expression) view of breast tumor progression. Cancer Res. 2001 Aug 01; 61(15):5697-702.Cancer Res2001-08-01T00:00:002001A SAGE (serial analysis of gene expression) view of breast tumor progression.Authorship 10252911Authorship 10461228Authorship 10453941429450494Sestak I, Buus R, Cuzick J, Dubsky P, Kronenwett R, Denkert C, Ferree S, Sgroi D, Schnabel C, Baehner FL, Mallon E, Dowsett MJAMA oncologyComparison of the Performance of 6 Prognostic Signatures for Estrogen Receptor-Positive Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial. JAMA Oncol. 2018 Apr 01; 4(4):545-553.JAMA Oncol2018-04-01T00:00:002018Comparison of the Performance of 6 Prognostic Signatures for Estrogen Receptor-Positive Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial.29453314Aceto N, Bardia A, Wittner BS, Donaldson MC, O'Keefe R, Engstrom A, Bersani F, Zheng Y, Comaills V, Niederhoffer K, Zhu H, Mackenzie O, Shioda T, Sgroi D, Kapur R, Ting DT, Moy B, Ramaswamy S, Toner M, Haber DA, Maheswaran SMolecular cancer research : MCRAR Expression in Breast Cancer CTCs Associates with Bone Metastases. Mol Cancer Res. 2018 04; 16(4):720-727.Mol Cancer Res2018-02-16T00:00:002018AR Expression in Breast Cancer CTCs Associates with Bone Metastases.11093943Easson AM, Pawlik TM, Fischer CP, Conroy JL, Sgroi D, Souba WW, Bode BPAmerican journal of physiology. Gastrointestinal and liver physiologyTumor-influenced amino acid transport activities in zonal-enriched hepatocyte populations. Am J Physiol Gastrointest Liver Physiol. 2000 Dec; 279(6):G1209-18.Am J Physiol Gastrointest Liver Physiol2000-12-01T00:00:002000Tumor-influenced amino acid transport activities in zonal-enriched hepatocyte populations.12208848Talora C, Sgroi DC, Crum CP, Dotto GPGenes & developmentSpecific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes Dev. 2002 Sep 01; 16(17):2252-63.Genes Dev2002-09-01T00:00:002002Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation.15908672Petricoin EF, Bichsel VE, Calvert VS, Espina V, Winters M, Young L, Belluco C, Trock BJ, Lippman M, Fishman DA, Sgroi DC, Munson PJ, Esserman LJ, Liotta LAJournal of clinical oncology : official journal of the American Society of Clinical OncologyMapping molecular networks using proteomics: a vision for patient-tailored combination therapy. J Clin Oncol. 2005 May 20; 23(15):3614-21.J Clin Oncol2005-05-20T00:00:002005Mapping molecular networks using proteomics: a vision for patient-tailored combination therapy.7923151Xu L, Sgroi D, Sterner CJ, Beauchamp RL, Pinney DM, Keel S, Ueki K, Rutter JL, Buckler AJ, Louis DNCancer researchMutational analysis of CDKN2 (MTS1/p16ink4) in human breast carcinomas. Cancer Res. 1994 Oct 15; 54(20):5262-4.Cancer Res1994-10-15T00:00:001994Mutational analysis of CDKN2 (MTS1/p16ink4) in human breast carcinomas.8191218Sgroi D, Stamenkovic IScandinavian journal of immunologyThe B-cell adhesion molecule CD22 is cross-species reactive and recognizes distinct sialoglycoproteins on different functional T-cell sub-populations. Scand J Immunol. 1994 May; 39(5):433-8.Scand J Immunol1994-05-01T00:00:001994The B-cell adhesion molecule CD22 is cross-species reactive and recognizes distinct sialoglycoproteins on different functional T-cell sub-populations.10973907Palmer-Toy DE, Sarracino DA, Sgroi D, LeVangie R, Leopold PEClinical chemistryDirect acquisition of matrix-assisted laser Desorption/Ionization time-of-flight mass spectra from laser capture microdissected tissues Clin Chem. 2000 Sep; 46(9):1513-6.Clin Chem2000-09-01T00:00:002000Direct acquisition of matrix-assisted laser Desorption/Ionization time-of-flight mass spectra from laser capture microdissected tissues17975144Wang Z, Dahiya S, Provencher H, Muir B, Carney E, Coser K, Shioda T, Ma XJ, Sgroi DCClinical cancer research : an official journal of the American Association for Cancer ResearchThe prognostic biomarkers HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer. Clin Cancer Res. 2007 Nov 01; 13(21):6327-34.Clin Cancer Res2007-11-01T00:00:002007The prognostic biomarkers HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer.18451222Ma XJ, Salunga R, Dahiya S, Wang W, Carney E, Durbecq V, Harris A, Goss P, Sotiriou C, Erlander M, Sgroi DClinical cancer research : an official journal of the American Association for Cancer ResearchA five-gene molecular grade index and HOXB13:IL17BR are complementary prognostic factors in early stage breast cancer. Clin Cancer Res. 2008 May 01; 14(9):2601-8.Clin Cancer Res2008-05-01T00:00:002008A five-gene molecular grade index and HOXB13:IL17BR are complementary prognostic factors in early stage breast cancer.19504246Marselli L, Sgroi DC, Bonner-Weir S, Weir GCMethods in molecular biology (Clifton, N.J.)Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profiling. Methods Mol Biol. 2009; 560:87-98.Methods Mol Biol2009-01-01T00:00:002009Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profiling.20100965Silver DP, Richardson AL, Eklund AC, Wang ZC, Szallasi Z, Li Q, Juul N, Leong CO, Calogrias D, Buraimoh A, Fatima A, Gelman RS, Ryan PD, Tung NM, De Nicolo A, Ganesan S, Miron A, Colin C, Sgroi DC, Ellisen LW, Winer EP, Garber JEJournal of clinical oncology : official journal of the American Society of Clinical OncologyEfficacy of neoadjuvant Cisplatin in triple-negative breast cancer. J Clin Oncol. 2010 Mar 01; 28(7):1145-53.J Clin Oncol2010-01-25T00:00:002010Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer.19187537Ma XJ, Dahiya S, Richardson E, Erlander M, Sgroi DCBreast cancer research : BCRGene expression profiling of the tumor microenvironment during breast cancer progression. Breast Cancer Res. 2009; 11(1):R7.Breast Cancer Res2009-02-02T00:00:002009Gene expression profiling of the tumor microenvironment during breast cancer progression.21240476Jermendy A, Toschi E, Aye T, Koh A, Aguayo-Mazzucato C, Sharma A, Weir GC, Sgroi D, Bonner-Weir SDiabetologiaRat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells. Diabetologia. 2011 Mar; 54(3):594-604.Diabetologia2011-01-16T00:00:002011Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells.22138009Febbo PG, Ladanyi M, Aldape KD, De Marzo AM, Hammond ME, Hayes DF, Iafrate AJ, Kelley RK, Marcucci G, Ogino S, Pao W, Sgroi DC, Birkeland MLJournal of the National Comprehensive Cancer Network : JNCCNNCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology. 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Biochem Biophys Res Commun. 1989 Jul 14; 162(1):138-43.Biochem Biophys Res Commun1989-07-14T00:00:001989Effects of H-7 are not exclusively mediated through protein kinase C or the cyclic nucleotide-dependent kinases.20215515Rothenberg SM, Mohapatra G, Rivera MN, Winokur D, Greninger P, Nitta M, Sadow PM, Sooriyakumar G, Brannigan BW, Ulman MJ, Perera RM, Wang R, Tam A, Ma XJ, Erlander M, Sgroi DC, Rocco JW, Lingen MW, Cohen EE, Louis DN, Settleman J, Haber DACancer researchA genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res. 2010 Mar 15; 70(6):2158-64.Cancer Res2010-03-09T00:00:002010A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.21125683Bombonati A, Sgroi DCThe Journal of pathologyThe molecular pathology of breast cancer progression. J Pathol. 2011 Jan; 223(2):307-17.J Pathol2010-11-16T00:00:002010The molecular pathology of breast cancer progression.21559019Jerevall PL, Ma XJ, Li H, Salunga R, Kesty NC, Erlander MG, Sgroi DC, Holmlund B, Skoog L, Fornander T, Nordenskjöld B, Stål OBritish journal of cancerPrognostic utility of HOXB13:IL17BR and molecular grade index in early-stage breast cancer patients from the Stockholm trial. Br J Cancer. 2011 May 24; 104(11):1762-9.Br J Cancer2011-05-10T00:00:002011Prognostic utility of HOXB13:IL17BR and molecular grade index in early-stage breast cancer patients from the Stockholm trial.Authorship 118857421818254Lee J, Hirsh AS, Wittner BS, Maeder ML, Singavarapu R, Lang M, Janarthanan S, McDermott U, Yajnik V, Ramaswamy S, Joung JK, Sgroi DCPloS oneInduction of stable drug resistance in human breast cancer cells using a combinatorial zinc finger transcription factor library. 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A 58-year-old woman with early-stage estrogen-receptor-positive breast cancer.15882617Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL, Weinberg RACellStromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell. 2005 May 06; 121(3):335-48.Cell2005-05-06T00:00:002005Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion.Authorship 11082621330350269Jerevall PL, Brock J, Palazzo J, Wieczorek T, Misialek M, Guidi AJ, Wu Y, Erlander MG, Zhang Y, Schnabel CA, Goss PE, Horick N, Sgroi DCBreast cancer research and treatmentDiscrepancy in risk assessment of hormone receptor positive early-stage breast cancer patients using breast cancer index and recurrence score. 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Cancer Res. 2011 Feb 01; 71(3):937-45.Cancer Res2010-12-02T00:00:002010The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast cancers.7568850Hulka CA, Smith BL, Sgroi DC, Tan L, Edmister WB, Semple JP, Campbell T, Kopans DB, Brady TJ, Weisskoff RMRadiologyBenign and malignant breast lesions: differentiation with echo-planar MR imaging. Radiology. 1995 Oct; 197(1):33-8.Radiology1995-10-01T00:00:001995Benign and malignant breast lesions: differentiation with echo-planar MR imaging.20080567Hayashida T, Takahashi F, Chiba N, Brachtel E, Takahashi M, Godin-Heymann N, Gross KW, Vivanco Md, Wijendran V, Shioda T, Sgroi D, Donahoe PK, Maheswaran SProceedings of the National Academy of Sciences of the United States of AmericaHOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis. 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Proc Natl Acad Sci U S A. 2003 May 13; 100(10):5974-9.Proc Natl Acad Sci U S A2003-04-24T00:00:002003Gene expression profiles of human breast cancer progression.15253443Zang L, Palmer Toy D, Hancock WS, Sgroi DC, Karger BLJournal of proteome researchProteomic analysis of ductal carcinoma of the breast using laser capture microdissection, LC-MS, and 16O/18O isotopic labeling. J Proteome Res. 2004 May-Jun; 3(3):604-12.J Proteome Res2004-05-01T00:00:002004Proteomic analysis of ductal carcinoma of the breast using laser capture microdissection, LC-MS, and 16O/18O isotopic labeling.15542428Sgroi DC, Haber DA, Ryan PD, Ma XJ, Erlander MGCancer cellRE: A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen. 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Genes Dev. 2008 Jan 15; 22(2):239-51.Genes Dev2008-01-15T00:00:002008Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling.Authorship 1070685D018123Chemicals & Drugs1452430.877667Receptors, InterleukinD013629Chemicals & Drugs4169780.687559TamoxifenD001943Disorders2830206760.141753Breast Neoplasms30911675Kabraji S, Sole X, Huang Y, Bango C, Sgroi D, Loda M, Ramaswamy SNPJ breast cancerAKT1low quiescent cancer cells in ductal carcinoma in situ of the breast. 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Cell. 2019 06 13; 177(7):1903-1914.e14.Cell2019-04-25T00:00:002019Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish.D018931Chemicals & Drugs45214970.530951Antineoplastic Agents, HormonalMedicinePathologyPediatricsSurgeryHematology/OncologyJoslinOncologyBrigham and Women's HospitalDana-Farber Cancer InstituteJoslin Diabetes CenterMassachusetts General HospitalGCW1GordonWeirGordon Campbell Weir, M.D.42.33839600000000-71.1084030000000076093Weir, GordonProfessor of MedicineBEB3BradleyBernsteinBradley E. Bernstein, M.D., Ph.D.42.37730000000000-71.0525000000000086Bernstein, BradleyProfessor of PathologyAHP1AnnPartridgeAnn Hart Partridge, M.D.42.33789600000000-71.1072493000000084598Partridge, AnnProfessor of MedicineAIM1AndreaMcClatcheyAndrea I. McClatchey, Ph.D.42.37730000000000-71.052500000000003924McClatchey, AndreaProfessor of PathologyDAH2DanielHaberDaniel Arie Haber, M.D., Ph.D.42.37730000000000-71.0525000000000010825Haber, DanielKurt J. Isselbacher Professor of Oncology11170selected publications2.614970.00277401704research areas1.938030.00867777118coauthor of83.935917.666260similar toPEG5PaulGossPaul E. Goss, M.B.,B.Ch., Ph.D.42.36241700000000-71.0689370000000042847Goss, PaulProfessor of MedicineAuthorship 1286930EPW2EricWinerEric Paul Winer, M.D.42.33789600000000-71.107249300000005538Winer, EricProfessor of Medicine, EmeritusMNR1MiguelRiveraMiguel Nicolas Rivera, M.D.42.37730000000000-71.0525000000000060452Rivera, MiguelAssociate Professor of PathologyAuthorship 1335146SM9ShyamalaMaheswaranShyamala Maheswaran, Ph.D.42.37730000000000-71.0525000000000010138Maheswaran, ShyamalaProfessor of SurgeryMM27MadhusmitaMisraMadhusmita Misra, M.B.,B.S.42.36241700000000-71.0689370000000060361Misra, MadhusmitaFritz Bradley Talbot and Nathan Bill Talbot Professor of Pediatrics, EmeritaDML4DavidLangenauDavid M. Langenau, Ph.D.42.37730000000000-71.0525000000000013067Langenau, DavidProfessor of PathologyAuthorship 1394256Authorship 11768611331371343Drago JZ, Formisano L, Juric D, Niemierko A, Servetto A, Wander SA, Spring LM, Vidula N, Younger J, Peppercorn J, Yuen M, Malvarosa G, Sgroi D, Isakoff SJ, Moy B, Ellisen LW, Iafrate AJ, Arteaga CL, Bardia AClinical cancer research : an official journal of the American Association for Cancer ResearchFGFR1 Amplification Mediates Endocrine Resistance but Retains TORC Sensitivity in Metastatic Hormone Receptor-Positive (HR+) Breast Cancer. Clin Cancer Res. 2019 11 01; 25(21):6443-6451.Clin Cancer Res2019-08-01T00:00:002019FGFR1 Amplification Mediates Endocrine Resistance but Retains TORC Sensitivity in Metastatic Hormone Receptor-Positive (HR+) Breast Cancer.Authorship 1466895Authorship 1191872231504126Bartlett JMS, Sgroi DC, Treuner K, Zhang Y, Ahmed I, Piper T, Salunga R, Brachtel EF, Pirrie SJ, Schnabel CA, Rea DWAnnals of oncology : official journal of the European Society for Medical OncologyBreast Cancer Index and prediction of benefit from extended endocrine therapy in breast cancer patients treated in the Adjuvant Tamoxifen-To Offer More? (aTTom) trial. Ann Oncol. 2019 11 01; 30(11):1776-1783.Ann Oncol2019-11-01T00:00:002019Breast Cancer Index and prediction of benefit from extended endocrine therapy in breast cancer patients treated in the Adjuvant Tamoxifen-To Offer More? (aTTom) trial.true1Kurt J. Isselbacher Professor of OncologyKurt J. Isselbacher Professor of Oncologytrue1Professor of PathologyProfessor of Pathologytrue1Professor of MedicineProfessor of Medicinetrue1Professor of PathologyProfessor of Pathologytrue1Professor of MedicineProfessor of Medicinetrue1Professor of MedicineProfessor of Medicinetrue1Professor of PathologyProfessor of PathologyAuthorship 1221555231987084Bartlett JMS, Sgroi DC, Treuner K, Zhang Y, Ahmed I, Piper T, Salunga R, Brachtel EF, Pirrie SJ, Schnabel CA, Rea DWAnnals of oncology : official journal of the European Society for Medical OncologyBreast Cancer Index and prediction of benefit from extended endocrine therapy in breast cancer patients treated in the Adjuvant Tamoxifen-To Offer More? (aTTom) trial. Ann Oncol. 2019 Nov; 30(11):1776-1783.Ann Oncol2020-01-08T00:00:002020Breast Cancer Index and prediction of benefit from extended endocrine therapy in breast cancer patients treated in the Adjuvant Tamoxifen-To Offer More? (aTTom) trial.true1Anne E. Dyson Professor of Surgery in the Field of Women's CancerAnne E. Dyson Professor of Surgery in the Field of Women's Cancertrue1Professor of SurgeryProfessor of SurgeryAuthorship 1672612Authorship 1869353true1Associate Professor of PathologyAssociate Professor of PathologyAuthorship 1493161true1Professor of SurgeryProfessor of SurgeryAuthorship 1359466Authorship 1425663Authorship 21427710Authorship 1959248Authorship 2174572Authorship 13643851134144976Li K, Li T, Feng Z, Huang M, Wei L, Yan Z, Long M, Hu Q, Wang J, Liu S, Sgroi DC, Demehri SScience advancesCD8+ T cell immunity blocks the metastasis of carcinogen-exposed breast cancer. Sci Adv. 2021 06; 7(25).Sci Adv2021-06-18T00:00:002021CD8+ T cell immunity blocks the metastasis of carcinogen-exposed breast cancer.23757354Zhang Y, Schnabel CA, Schroeder BE, Jerevall PL, Jankowitz RC, Fornander T, Stål O, Brufsky AM, Sgroi D, Erlander MGClinical cancer research : an official journal of the American Association for Cancer ResearchBreast cancer index identifies early-stage estrogen receptor-positive breast cancer patients at risk for early- and late-distant recurrence. Clin Cancer Res. 2013 Aug 01; 19(15):4196-205.Clin Cancer Res2013-06-11T00:00:002013Breast cancer index identifies early-stage estrogen receptor-positive breast cancer patients at risk for early- and late-distant recurrence.Authorship 13852851134376532Nunes R, Sella T, Treuner K, Atkinson JM, Wong J, Zhang Y, Exman P, Dabbs D, Richardson AL, Schnabel CA, Sgroi DC, Oesterreich S, Cimino-Mathews A, Metzger OClinical cancer research : an official journal of the American Association for Cancer ResearchPrognostic Utility of Breast Cancer Index to Stratify Distant Recurrence Risk in Invasive Lobular Carcinoma. Clin Cancer Res. 2021 10 15; 27(20):5688-5696.Clin Cancer Res2021-08-10T00:00:002021Prognostic Utility of Breast Cancer Index to Stratify Distant Recurrence Risk in Invasive Lobular Carcinoma.Authorship 1834163Authorship 1860941Authorship 1893206Authorship 2007031Authorship 2257502Authorship 1430689235144966Bartlett JMS, Sgroi DC, Treuner K, Zhang Y, Piper T, Salunga RC, Ahmed I, Doos L, Thornber S, Taylor KJ, Brachtel EF, Pirrie SJ, Schnabel CA, Rea DWClinical cancer research : an official journal of the American Association for Cancer ResearchBreast Cancer Index Is a Predictive Biomarker of Treatment Benefit and Outcome from Extended Tamoxifen Therapy: Final Analysis of the Trans-aTTom Study. Clin Cancer Res. 2022 05 02; 28(9):1871-1880.Clin Cancer Res2022-05-02T00:00:002022Breast Cancer Index Is a Predictive Biomarker of Treatment Benefit and Outcome from Extended Tamoxifen Therapy: Final Analysis of the Trans-aTTom Study.Authorship 1438819235218378Lopez DR, Sgroi D, Krishnamourthy S, Tearney GVirchows Archiv : an international journal of pathologyIs Real-Time Microscopy on the Horizon? A Brief Review of the Potential Future Directions in Clinical Breast Tumor Microscopy Implementation. Virchows Arch. 2022 Jan; 480(1):211-227.Virchows Arch2022-02-26T00:00:002022Is Real-Time Microscopy on the Horizon? A Brief Review of the Potential Future Directions in Clinical Breast Tumor Microscopy Implementation.Authorship 3752502Authorship 46543011Authorship 1514386136527133Sgroi DC, Treuner K, Zhang Y, Piper T, Salunga R, Ahmed I, Doos L, Thornber S, Taylor KJ, Brachtel E, Pirrie S, Schnabel CA, Rea D, Bartlett JMSBreast cancer research : BCRCorrelative studies of the Breast Cancer Index (HOXB13/IL17BR) and ER, PR, AR, AR/ER ratio and Ki67 for prediction of extended endocrine therapy benefit: a Trans-aTTom study. Breast Cancer Res. 2022 12 16; 24(1):90.Breast Cancer Res2022-12-16T00:00:002022Correlative studies of the Breast Cancer Index (HOXB13/IL17BR) and ER, PR, AR, AR/ER ratio and Ki67 for prediction of extended endocrine therapy benefit: a Trans-aTTom study.Authorship 25186010Authorship 2288807Authorship 1586160237771083Boyraz B, Sgroi DC, Iafrate AJ, Lerwill MFHistopathologyAtypical cystic hypersecretory lesions of the breast commonly harbour TP53 alterations. Histopathology. 2023 Dec; 83(6):989-993.Histopathology2023-09-28T00:00:002023Atypical cystic hypersecretory lesions of the breast commonly harbour TP53 alterations.true1Professor of PathologyProfessor of Pathologytrue1Professor of Medicine, EmeritusProfessor of Medicine, Emeritustrue1Fritz Bradley Talbot and Nathan Bill Talbot Professor of Pediatrics, EmeritaFritz Bradley Talbot and Nathan Bill Talbot Professor of Pediatrics, EmeritaAuthorship 16326741638376912Mamounas EP, Bandos H, Rastogi P, Zhang Y, Treuner K, Lucas PC, Geyer CE, Fehrenbacher L, Chia SK, Brufsky AM, Walshe JM, Soori GS, Dakhil S, Paik S, Swain SM, Sgroi DC, Schnabel CA, Wolmark NClinical cancer research : an official journal of the American Association for Cancer ResearchBreast Cancer Index and Prediction of Extended Aromatase Inhibitor Therapy Benefit in Hormone Receptor-positive Breast Cancer from the NRG Oncology/NSABP B-42 Trial. Clin Cancer Res. 2024 Feb 20.Clin Cancer Res2024-02-20T00:00:002024Breast Cancer Index and Prediction of Extended Aromatase Inhibitor Therapy Benefit in Hormone Receptor-positive Breast Cancer from the NRG Oncology/NSABP B-42 Trial.Authorship 5584282Authorship 29033511Authorship 2609364Authorship 64452846Authorship 6680549Authorship 6486885Authorship 6683941523670096Weiner M, Skoog L, Fornander T, Nordenskjöld B, Sgroi DC, Stål OAnnals of oncology : official journal of the European Society for Medical OncologyOestrogen receptor co-activator AIB1 is a marker of tamoxifen benefit in postmenopausal breast cancer. Ann Oncol. 2013 Aug; 24(8):1994-9.Ann Oncol2013-05-12T00:00:002013Oestrogen receptor co-activator AIB1 is a marker of tamoxifen benefit in postmenopausal breast cancer.23755103Price JC, Pollock LM, Rudd ML, Fogoros SK, Mohamed H, Hanigan CL, Le Gallo M, Zhang S, Cruz P, Cherukuri PF, Hansen NF, McManus KJ, Godwin AK, Sgroi DC, Mullikin JC, Merino MJ, Hieter P, Bell DWPloS oneSequencing of candidate chromosome instability genes in endometrial cancers reveals somatic mutations in ESCO1, CHTF18, and MRE11A. 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Lancet Oncol. 2013 Oct; 14(11):1067-1076.Lancet Oncol2013-09-12T00:00:002013Prediction of late distant recurrence in patients with oestrogen-receptor-positive breast cancer: a prospective comparison of the breast-cancer index (BCI) assay, 21-gene recurrence score, and IHC4 in the TransATAC study population.Authorship 2943692Authorship 314052Authorship 1929955Authorship 2283641Authorship 701979724346130Wong JS, Chen YH, Gadd MA, Gelman R, Lester SC, Schnitt SJ, Sgroi DC, Silver BJ, Smith BL, Troyan SL, Harris JRBreast cancer research and treatmentEight-year update of a prospective study of wide excision alone for small low- or intermediate-grade ductal carcinoma in situ (DCIS). Breast Cancer Res Treat. 2014 Jan; 143(2):343-50.Breast Cancer Res Treat2013-12-18T00:00:002013Eight-year update of a prospective study of wide excision alone for small low- or intermediate-grade ductal carcinoma in situ (DCIS).Authorship 195196Authorship 2840524Authorship 3284417Authorship 7250097Authorship 721600724131622Karlsson E, Pérez-Tenorio G, Amin R, Bostner J, Skoog L, Fornander T, Sgroi DC, Nordenskjöld B, Hallbeck AL, Stål OBreast cancer research : BCRThe mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer: a retrospective study including patients from the randomised Stockholm tamoxifen trials. Breast Cancer Res. 2013; 15(5):R96.Breast Cancer Res2013-01-01T00:00:002013The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer: a retrospective study including patients from the randomised Stockholm tamoxifen trials.24715381Sjöström M, Hartman L, Grabau D, Fornander T, Malmström P, Nordenskjöld B, Sgroi DC, Skoog L, Stål O, Leeb-Lundberg LM, Fernö MBreast cancer research and treatmentLack of G protein-coupled estrogen receptor (GPER) in the plasma membrane is associated with excellent long-term prognosis in breast cancer. Breast Cancer Res Treat. 2014 May; 145(1):61-71.Breast Cancer Res Treat2014-04-09T00:00:002014Lack of G protein-coupled estrogen receptor (GPER) in the plasma membrane is associated with excellent long-term prognosis in breast cancer.25013076Yu M, Bardia A, Aceto N, Bersani F, Madden MW, Donaldson MC, Desai R, Zhu H, Comaills V, Zheng Z, Wittner BS, Stojanov P, Brachtel E, Sgroi D, Kapur R, Shioda T, Ting DT, Ramaswamy S, Getz G, Iafrate AJ, Benes C, Toner M, Maheswaran S, Haber DAScience (New York, N.Y.)Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility. Science. 2014 Jul 11; 345(6193):216-20.Science2014-07-11T00:00:002014Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility.Authorship 74154914Authorship 74244514Authorship 74353417Authorship 741696624625110McMullin RP, Wittner BS, Yang C, Denton-Schneider BR, Hicks D, Singavarapu R, Moulis S, Lee J, Akbari MR, Narod SA, Aldape KD, Steeg PS, Ramaswamy S, Sgroi DCBreast cancer research : BCRA BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity. Breast Cancer Res. 2014 Mar 14; 16(2):R25.Breast Cancer Res2014-03-14T00:00:002014A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity.23497539Habel LA, Sakoda LC, Achacoso N, Ma XJ, Erlander MG, Sgroi DC, Fehrenbacher L, Greenberg D, Quesenberry CPBreast cancer research : BCRHOXB13:IL17BR and molecular grade index and risk of breast cancer death among patients with lymph node-negative invasive disease. Breast Cancer Res. 2013 Mar 14; 15(2):R24.Breast Cancer Res2013-03-14T00:00:002013HOXB13:IL17BR and molecular grade index and risk of breast cancer death among patients with lymph node-negative invasive disease.24886537Aguilar H, Urruticoechea A, Halonen P, Kiyotani K, Mushiroda T, Barril X, Serra-Musach J, Islam A, Caizzi L, Di Croce L, Nevedomskaya E, Zwart W, Bostner J, Karlsson E, Pérez Tenorio G, Fornander T, Sgroi DC, Garcia-Mata R, Jansen MP, García N, Bonifaci N, Climent F, Soler MT, Rodríguez-Vida A, Gil M, Brunet J, Martrat G, Gómez-Baldó L, Extremera AI, Figueras A, Balart J, Clarke R, Burnstein KL, Carlson KE, Katzenellenbogen JA, Vizoso M, Esteller M, Villanueva A, Rodríguez-Peña AB, Bustelo XR, Nakamura Y, Zembutsu H, Stål O, Beijersbergen RL, Pujana MABreast cancer research : BCRVAV3 mediates resistance to breast cancer endocrine therapy. Breast Cancer Res. 2014 May 28; 16(3):R53.Breast Cancer Res2014-05-28T00:00:002014VAV3 mediates resistance to breast cancer endocrine therapy.Authorship 362246Authorship 4986352Authorship 5059811Authorship 5221961Authorship 3870775Authorship 4525454Authorship 48504114Authorship 4640119Authorship 470278Authorship 4264305Authorship 4991891Authorship 4418436Authorship 4428614Authorship 77360014Authorship 7735561225489927Shen K, Luk S, Hicks DF, Elman JS, Bohr S, Iwamoto Y, Murray R, Pena K, Wang F, Seker E, Weissleder R, Yarmush ML, Toner M, Sgroi D, Parekkadan BNature communicationsResolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays. Nat Commun. 2014 Dec 09; 5:5662.Nat Commun2014-12-09T00:00:002014Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays.25427824Rudd ML, Mohamed H, Price JC, O'Hara AJ, Le Gallo M, Urick ME, Cruz P, Zhang S, Hansen NF, Godwin AK, Sgroi DC, Wolfsberg TG, Mullikin JC, Merino MJ, Bell DWBMC cancerMutational analysis of the tyrosine kinome in serous and clear cell endometrial cancer uncovers rare somatic mutations in TNK2 and DDR1. BMC Cancer. 2014 Nov 26; 14:884.BMC Cancer2014-11-26T00:00:002014Mutational analysis of the tyrosine kinome in serous and clear cell endometrial cancer uncovers rare somatic mutations in TNK2 and DDR1.Authorship 4762518Authorship 49762112Authorship 777319425521819Olsen L, Campos B, Winther O, Sgroi DC, Karger BL, Brusic VBMC medical genomicsTumor antigens as proteogenomic biomarkers in invasive ductal carcinomas. 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Nature. 2015 Feb 12; 518(7538):240-4.Nature2014-11-17T00:00:002014Convergent loss of PTEN leads to clinical resistance to a PI(3)Ka inhibitor.Authorship 971085Authorship 2589734Authorship 26292036Authorship 3003692Authorship 3406962Authorship 367582Authorship 4393723Authorship 548604Authorship 29711617Authorship 3015616Authorship 4464457Authorship 4988476TAK17TariKingTari Ann King, M.D.143212King, TariAnne E. Dyson Professor of Surgery in the Field of Women's CancerAuthorship 901855Authorship 843134826479444Miyoshi N, Wittner BS, Shioda K, Hitora T, Ito T, Ramaswamy S, Isselbacher KJ, Sgroi DC, Shioda TOncogenesisNodes-and-connections RNAi knockdown screening: identification of a signaling molecule network involved in fulvestrant action and breast cancer prognosis. Oncogenesis. 2015 Oct 19; 4:e172.Oncogenesis2015-10-19T00:00:002015Nodes-and-connections RNAi knockdown screening: identification of a signaling molecule network involved in fulvestrant action and breast cancer prognosis.Authorship 856272126728744Sgroi DC, Chapman JA, Badovinac-Crnjevic T, Zarella E, Binns S, Zhang Y, Schnabel CA, Erlander MG, Pritchard KI, Han L, Shepherd LE, Goss PE, Pollak MBreast cancer research : BCRAssessment of the prognostic and predictive utility of the Breast Cancer Index (BCI): an NCIC CTG MA.14 study. Breast Cancer Res. 2016 Jan 04; 18(1):1.Breast Cancer Res2016-01-04T00:00:002016Assessment of the prognostic and predictive utility of the Breast Cancer Index (BCI): an NCIC CTG MA.14 study.Authorship 5141078Authorship 5253771Authorship 572313Authorship 639638Authorship 3578964Authorship 877380527096583Misra M, Sagar P, Friedmann AM, Ryan DP, Sgroi DCThe New England journal of medicineCASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 12-2016. An 8-Year-Old Boy with an Enlarging Mass in the Right Breast. N Engl J Med. 2016 Apr 21; 374(16):1565-74.N Engl J Med2016-04-21T00:00:002016CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 12-2016. An 8-Year-Old Boy with an Enlarging Mass in the Right Breast.Authorship 882241227116182Chapman JA, Sgroi DC, Goss PE, Zarella E, Binns S, Zhang Y, Schnabel CA, Erlander MG, Pritchard KI, Han L, Badovinac-Crnjevic T, Shepherd LE, Pollak MNBreast cancer research and treatmentRelapse-free survival of statistically standardized continuous RT-PCR estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2): NCIC CTG MA.14. Breast Cancer Res Treat. 2016 05; 157(1):101-8.Breast Cancer Res Treat2016-04-26T00:00:002016Relapse-free survival of statistically standardized continuous RT-PCR estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2): NCIC CTG MA.14.Authorship 52532721Associate Professor0Full Professor1997-08-31SGROI, DENNIS C1994-09-01FUNCTIONAL ROLE OF CD22 DURING THE IMMUNE RESPONSEK08AI0012522015-04-30SGROI, DENNIS C2005-03-11A NOVEL BREAST CANCER BIOMARKERR01CA112021Principal InvestigatorPrincipal InvestigatorAuthorship 905447Authorship 3611655Authorship 39390720Authorship 9219637Authorship 926617627252417Sestak I, Zhang Y, Schroeder BE, Schnabel CA, Dowsett M, Cuzick J, Sgroi DClinical cancer research : an official journal of the American Association for Cancer ResearchCross-Stratification and Differential Risk by Breast Cancer Index and Recurrence Score in Women with Hormone Receptor-Positive Lymph Node-Negative Early-Stage Breast Cancer. 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