Edward Mallinckrodt, Jr. Professor of Anaesthesia in the Field Pharmacology and Innovation, Emeritus
Sewell JC, Raines DE, Laster M, Eger EI, Sear JW
Comparison of the molecular bases for NMDA-receptor inhibition versus immobilizing activities of volatile aromatic anesthetics. Anesth Analg. 2008; in press.
Comparison of the molecular bases for NMDA-receptor inhibition versus immobilizing activities of volatile aromatic anesthetics
Annual Meeting of the Research Society on Alcoholism
Lipids modulate ethanol-induced desensitization of nicotinic acetylcholine receptors. Annual Meeting of the Research Society on Alcoholism. 1995.
Lipids modulate ethanol-induced desensitization of nicotinic acetylcholine receptors
Spin-label studies into the effects of ethanol on lipid- protein interactions in reconstituted acetylcholine receptor vesicles. Biophysical Journal. 1993.
Spin-label studies into the effects of ethanol on lipid- protein interactions in reconstituted acetylcholine receptor vesicles
The kinetics of halothane interactions with nicotinic acetylcholine receptor membranes: stopped-flow studies of intrinsic fluorescence quenching. Anesthesiology. 1996.
The kinetics of halothane interactions with nicotinic acetylcholine receptor membranes: stopped-flow studies of intrinsic fluorescence quenching
Raines DE, Korten SE, Hill AG, Miller KW
Anesthetic cutoff in cycloalkanemethanols. A test of current theories. Anesthesiology. 1993 May; 78(5):918-27.
Anesthetic cutoff in cycloalkanemethanols. A test of current theories.
Anesthetic Drug Discovery and Development: A Case Study of Novel Etomidate Analogs. Methods Enzymol. 2018; 603:153-169.
Anesthetic Drug Discovery and Development: A Case Study of Novel Etomidate Analogs.
Pejo E, Cotten JF, Kelly EW, Le Ge R, Cuny GD, Laha JK, Liu J, Lin XJ, Raines DE
In vivo and in vitro pharmacological studies of methoxycarbonyl-carboetomidate. Anesth Analg. 2012 Aug; 115(2):297-304.
In vivo and in vitro pharmacological studies of methoxycarbonyl-carboetomidate.
Longnecker D., Brown D., Newman M., and Zapol W., Eds., Principles and Practice of Anesthesiology,
Anesthesia for Liver Surgery and Transplantation. Longnecker D., Brown D., Newman M., and Zapol W., Eds., Principles and Practice of Anesthesiology,. 2007; 1338-1377.
Anesthesia for Liver Surgery and Transplantation
The Variable Effects of Volatile Aromatic Anesthetics on GABA A Receptor Function. Anesthesiology. 2007; A8.
The Variable Effects of Volatile Aromatic Anesthetics on GABA A Receptor Function
Electron spin resonance studies of acyl chain motion in reconstituted nicotinic acetylcholine receptor membranes. Biophys J. 1995 Aug; 69(2):498-505.
Electron spin resonance studies of acyl chain motion in reconstituted nicotinic acetylcholine receptor membranes.
Rüsch D, Braun HA, Wulf H, Schuster A, Raines DE
Inhibition of human 5-HT(3A) and 5-HT(3AB) receptors by etomidate, propofol and pentobarbital. Eur J Pharmacol. 2007 Nov 14; 573(1-3):60-4.
Inhibition of human 5-HT(3A) and 5-HT(3AB) receptors by etomidate, propofol and pentobarbital.
Dutton RC, Laster MJ, Xing Y, Sonner JM, Raines DE, Solt K, Eger EI
Do N-methyl-D-aspartate receptors mediate the capacity of inhaled anesthetics to suppress the temporal summation that contributes to minimum alveolar concentration? Anesth Analg. 2006 May; 102(5):1412-8.
Do N-methyl-D-aspartate receptors mediate the capacity of inhaled anesthetics to suppress the temporal summation that contributes to minimum alveolar concentration?
Raines DE, Kortin SE, Hill WAG, Miller KW
Lipid disordering predicts anesthetic cutoff in cycloalkanemethanols. Anesthesiology. 1992; 2:757.
Lipid disordering predicts anesthetic cutoff in cycloalkanemethanols
Nguyen L, Blust M, Bailin M, Melendez L, Raines DE
Photosensitivity and perioperative polyneuropathy complicating orthotopic liver transplantation in a patient with erythropoietic protoporphyria. Anesthesiology. 1999 Oct; 91(4):1173-5.
Photosensitivity and perioperative polyneuropathy complicating orthotopic liver transplantation in a patient with erythropoietic protoporphyria.
Clinical Anesthesia Procedures of the Massachusetts General Hospital
Intra-anesthetic Problems. Clinical Anesthesia Procedures of the Massachusetts General Hospital. 1993.
Anesthetic Action on the Nicotinic Acetylcholine Receptor. Neural Mechanisms of Anesthesia. 2002; 283-298.
Anesthetic Action on the Nicotinic Acetylcholine Receptor
Cotten JF, Le Ge R, Banacos N, Pejo E, Husain SS, Williams JH, Raines DE
Closed-loop continuous infusions of etomidate and etomidate analogs in rats: a comparative study of dosing and the impact on adrenocortical function. Anesthesiology. 2011 Oct; 115(4):764-73.
Closed-loop continuous infusions of etomidate and etomidate analogs in rats: a comparative study of dosing and the impact on adrenocortical function.
Ge R, Pejo E, Husain SS, Cotten JF, Raines DE
Electroencephalographic and hypnotic recoveries after brief and prolonged infusions of etomidate and optimized soft etomidate analogs. Anesthesiology. 2012 Nov; 117(5):1037-43.
Electroencephalographic and hypnotic recoveries after brief and prolonged infusions of etomidate and optimized soft etomidate analogs.
Stein M, Middendorp SJ, Carta V, Pejo E, Raines DE, Forman SA, Sigel E, Trauner D
Angewandte Chemie (International ed. in English)
Azo-propofols: photochromic potentiators of GABA(A) receptors. Angew Chem Int Ed Engl. 2012 Oct 15; 51(42):10500-4.
Azo-propofols: photochromic potentiators of GABA(A) receptors.
Zhang Y, Sonner JM, Eger EI, Stabernack CR, Laster MJ, Raines DE, Harris RA
Gamma-aminobutyric acidA receptors do not mediate the immobility produced by isoflurane. Anesth Analg. 2004 Jul; 99(1):85-90.
Gamma-aminobutyric acidA receptors do not mediate the immobility produced by isoflurane.
Cation-pi interactions modulate the NMDA receptor potencies of inhaled aromatic anesthetics. International Congress Series. 2005; 85-9.
Cation-pi interactions modulate the NMDA receptor potencies of inhaled aromatic anesthetics
Isoflurane Accelerates the Activation and Deactivation Rates of Human 5-HT3A Receptors. Anesthesiology. 2006; A174.
Isoflurane Accelerates the Activation and Deactivation Rates of Human 5-HT3A Receptors
Stevens RS, Rusch D, Solt K, Raines DE, Davies PA
Volatile anesthetics enhance the open probability of 5-HT3A channels. 2004; A-584.
Volatile anesthetics enhance the open probability of 5-HT3A channels
Stewart DS, Savechenkov PY, Dostalova Z, Chiara DC, Ge R, Raines DE, Cohen JB, Forman SA, Bruzik KS, Miller KW
p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol. J Med Chem. 2011 Dec 08; 54(23):8124-35.
p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol.
McGrath M, Yu Z, Jayakar SS, Ma C, Tolia M, Zhou X, Miller KW, Cohen JB, Raines DE
Etomidate and Etomidate Analog Binding and Positive Modulation of ?-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect. Anesthesiology. 2018 11; 129(5):959-969.
Etomidate and Etomidate Analog Binding and Positive Modulation of ?-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect.
Electron Spin Resonance (ESR) studies into the origin of selectivity for negatively charged lipids at the lipid-protein interface of the nicotinic acetylcholine receptor. The Pharmacologist. 1992; 34(3):296.
Electron Spin Resonance (ESR) studies into the origin of selectivity for negatively charged lipids at the lipid-protein interface of the nicotinic acetylcholine receptor
Sewell JC, Raines DE, Eger EI, Laster MJ, Sear JW
A comparison of the molecular bases for N-methyl-D-aspartate-receptor inhibition versus immobilizing activities of volatile aromatic anesthetics. Anesth Analg. 2009 Jan; 108(1):168-75.
A comparison of the molecular bases for N-methyl-D-aspartate-receptor inhibition versus immobilizing activities of volatile aromatic anesthetics.
Cotten JF, Husain SS, Forman SA, Miller KW, Kelly EW, Nguyen HH, Raines DE
Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression. Anesthesiology. 2009 Aug; 111(2):240-9.
Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression.
Pejo E, Feng Y, Chao W, Cotten JF, Le Ge R, Raines DE
Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia. Crit Care Med. 2012 Jan; 40(1):187-92.
Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia.
Solt K, Davies P, Stevens R, Rusch D, Raines DE
Introduction of the 5-HT3B subunit decreases the sensitivity of 5-HT3A receptors to the potentiating actions of general anesthetics. Anesthesiology. 2004; A-107.
Introduction of the 5-HT3B subunit decreases the sensitivity of 5-HT3A receptors to the potentiating actions of general anesthetics
Eger EI, Tang M, Liao M, Laster MJ, Solt K, Flood P, Jenkins A, Raines D, Hendrickx JF, Shafer SL, Yasumasa T, Sonner JM
Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats. Anesth Analg. 2008 Aug; 107(2):479-85.
Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats.
Savechenkov PY, Zhang X, Chiara DC, Stewart DS, Ge R, Zhou X, Raines DE, Cohen JB, Forman SA, Miller KW, Bruzik KS
Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic. J Med Chem. 2012 Jul 26; 55(14):6554-65.
Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.
Antognini JF, and Raines DE, Carstens EE
The Future of Anesthetic Mechanisms Research. Neural Mechanisms of Anesthesia. 2002; 449-453.
The Future of Anesthetic Mechanisms Research
Nonanesthetic Haloalkanes and Nicotinic Acetylcholine Receptor Desensitization Kinetics. Anesthesiology. 1996; 85:431-432.
Nonanesthetic Haloalkanes and Nicotinic Acetylcholine Receptor Desensitization Kinetics
Feinberg-Zadek PL, Rusch D, Solt K, Raines DE, Davies PA
35th annual meeting for the Society for Neurosciences
The 5-HT3B subunit influences 5-HT3 receptor kinetics and pharmacology. 35th annual meeting for the Society for Neurosciences. 2005.
The 5-HT3B subunit influences 5-HT3 receptor kinetics and pharmacology
Stevens RJN, Rüsch D, Davies PA, Raines DE
Molecular properties important for inhaled anesthetic action on human 5-HT3A receptors. Anesth Analg. 2005 Jun; 100(6):1696-1703.
Molecular properties important for inhaled anesthetic action on human 5-HT3A receptors.
Rüsch D, Musset B, Wulf H, Schuster A, Raines DE
The Journal of pharmacology and experimental therapeutics
Subunit-dependent modulation of the 5-hydroxytryptamine type 3 receptor open-close equilibrium by n-alcohols. J Pharmacol Exp Ther. 2007 Jun; 321(3):1069-74.
Subunit-dependent modulation of the 5-hydroxytryptamine type 3 receptor open-close equilibrium by n-alcohols.
53rd Annual Meeting of the Association of University
Kinetics of anesthetic-induced conformational transitions in a four-alpha-helix bundle protein. 53rd Annual Meeting of the Association of University. 2006.
Kinetics of anesthetic-induced conformational transitions in a four-alpha-helix bundle protein
Molecular and Basic Mechanisms of Anesthesia
Inhibition of alpha4beta2 rat neuronal nicotinic receptors by nonhalogenated alkane anesthetics and perhalogenated alkane nonimmobilizers. Molecular and Basic Mechanisms of Anesthesia. 2002; 115-119.
Inhibition of alpha4beta2 rat neuronal nicotinic receptors by nonhalogenated alkane anesthetics and perhalogenated alkane nonimmobilizers
General anesthetics modify the kinetics of nicotinic acetylcholine receptor desensitization at clinically relevant concentrations. Anesthesiology. 1995 Jan; 82(1):276-87; discussion 31A-32A.
General anesthetics modify the kinetics of nicotinic acetylcholine receptor desensitization at clinically relevant concentrations.
Volatile anesthetics reduce the agonist EC50 of the human 5-HT3A receptor by increasing channel gating probability. Anesthesiology. 2004; A-106.
Volatile anesthetics reduce the agonist EC50 of the human 5-HT3A receptor by increasing channel gating probability
The fluorescent agonist Dns-C6-Cho binds with micromolar affinity to the alpha-delta binding site of the nicotinic acetylcholine receptor resting state. Biophysical Journal. 1999.
The fluorescent agonist Dns-C6-Cho binds with micromolar affinity to the alpha-delta binding site of the nicotinic acetylcholine receptor resting state
Abadji V, Raines DE, Dalton LA, Miller KW
Lipid-protein interactions and protein dynamics in vesicles containing the nicotinic acetylcholine receptor: a study with ethanol. Biochim Biophys Acta. 1994 Aug 24; 1194(1):25-34.
Lipid-protein interactions and protein dynamics in vesicles containing the nicotinic acetylcholine receptor: a study with ethanol.
Abadji VC, Raines DE, Watts A, Miller KW
The effect of general anesthetics on the dynamics of phosphatidylcholine-acetylcholine receptor interactions in reconstituted vesicles. Biochim Biophys Acta. 1993 Apr 08; 1147(1):143-53.
The effect of general anesthetics on the dynamics of phosphatidylcholine-acetylcholine receptor interactions in reconstituted vesicles.
The pyrrole etomidate analog carboetomidate potently inhibits human 5-HT3A receptor function: comparisons with etomidate and potential implications for emetogenesis. Anesth Analg. 2013 Mar; 116(3):573-9.
The pyrrole etomidate analog carboetomidate potently inhibits human 5-HT3A receptor function: comparisons with etomidate and potential implications for emetogenesis.
Sandberg WS, Spring SF, Anupama S, Raines DE
Improving billing effectiveness with automated anesthesia information management. Anesthesiology. 2006.
Improving billing effectiveness with automated anesthesia information management
Intra-anesthetic Problems. Clinical Anesthesia Procedures of the Massachusetts General Hospital. 2002.
Isoflurane's actions on the nicotinic acetylcholine receptor are dependent upon the composition of the lipid bilayer. Anesthesiology. 1994.
Isoflurane's actions on the nicotinic acetylcholine receptor are dependent upon the composition of the lipid bilayer
Molecular and Cellular Mechanisms of General Anesthesia
Conformational transitions of the nicotinic acetylcholine receptor as a model for anesthetic actions on ligand-gated ion channels: single and sequential mixing stopped-flow fluorescence studies. Molecular and Cellular Mechanisms of General Anesthesia. 1998; 100-101:163-168.
Conformational transitions of the nicotinic acetylcholine receptor as a model for anesthetic actions on ligand-gated ion channels: single and sequential mixing stopped-flow fluorescence studies
The Interactions of General Anesthetics with Membranes. Anesthesia: Biologic Foundations. 1994; 5-18.
The Interactions of General Anesthetics with Membranes
41st Annual Meeting of the Association of University
General anesthetic effects on nicotinic acetylcholine receptor conformational states are dependent upon lipid composition. 41st Annual Meeting of the Association of University. 1994.
General anesthetic effects on nicotinic acetylcholine receptor conformational states are dependent upon lipid composition
Cotten JF, Forman SA, Laha JK, Cuny GD, Husain SS, Miller KW, Nguyen HH, Kelly EW, Stewart D, Liu A, Raines DE
Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function. Anesthesiology. 2010 Mar; 112(3):637-44.
Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function.
Carboetomidate inhibits alpha4/beta2 neuronal nicotinic acetylcholine receptors at concentrations affecting animals. Anesth Analg. 2012 Jul; 115(1):70-2.
Carboetomidate inhibits alpha4/beta2 neuronal nicotinic acetylcholine receptors at concentrations affecting animals.
Ruesch D, Mittelstein M, Wulf H, Raines DE
Butanol Increases Channel Gating Probability in Human 5-HT3A Receptors. Anesthesiology. 2006; A174.
Butanol Increases Channel Gating Probability in Human 5-HT3A Receptors
Sewell JC, Sear JW, Raines DE, Eger EI, Laster MJ
The Molecular Basis of NMDA Receptor Inhibition by Aromatic Volatile General Anesthetics. Anesthesiology. 2006; A776.
The Molecular Basis of NMDA Receptor Inhibition by Aromatic Volatile General Anesthetics
Isoflurane increases the apparent agonist affinity of the nicotinic acetylcholine receptor by reducing the microscopic agonist dissociation constant. Anesthesiology. 2000 Mar; 92(3):775-85.
Isoflurane increases the apparent agonist affinity of the nicotinic acetylcholine receptor by reducing the microscopic agonist dissociation constant.
Kinetics of anesthetic-induced conformational transitions in a four-alpha-helix bundle protein. Biochemistry. 2006 Feb 07; 45(5):1435-41.
Kinetics of anesthetic-induced conformational transitions in a four-alpha-helix bundle protein.
General anesthetics increase the apparent agonist affinity of the nicotinic acetylcholine receptor: a case of (super)family resemblance. Anesthesiology. 1999.
General anesthetics increase the apparent agonist affinity of the nicotinic acetylcholine receptor: a case of (super)family resemblance
Kinetic modeling of isoflurane’s effect on nicotinic acetylcholine receptor desensitization implicates a reduction in the agonist dissociation constant. Anesthesiology. 1999.
Kinetic modeling of isoflurane’s effect on nicotinic acetylcholine receptor desensitization implicates a reduction in the agonist dissociation constant
Intra-anesthetic Problems. Clinical Anesthesia Procedures of the Massachusetts General Hospital. 1998; 287-312.
Raines DE, Scheller M, Forman SA, Claycomb RJ
Selective Receptor Actions of Nonhalogenated Alkane Anesthetics. Molecular and Basic Mechanisms of Anesthesia. 2002.
Selective Receptor Actions of Nonhalogenated Alkane Anesthetics
Antognini JF, Raines DE, Solt K, Barter L, Atherley R, Laster M, Eger E
Hexafluorobenzene Acts in the Spinal Cord, While 0-diflurobenzene Can Act in Either Brain or Spinal Cord, to Produce Immobility. Society for Neuroscience Meeting. 2006; A174.
Hexafluorobenzene Acts in the Spinal Cord, While 0-diflurobenzene Can Act in Either Brain or Spinal Cord, to Produce Immobility
On the importance of volatile agents devoid of anesthetic action. Anesth Analg. 1994 Dec; 79(6):1031-3.
On the importance of volatile agents devoid of anesthetic action.
Mallinckrodt Professor of Pharmacology in the Department of Anaesthesia
John Homans Professor of Surgery, Emeritus
Valk BI, McGrath M, Lehoux D, Zerler B, Marota JJA, Raines DE
Toxicologic and Inhibitory Receptor Actions of the Etomidate Analog ABP-700 and Its Metabolite CPM-Acid. Anesthesiology. 2019 08; 131(2):287-304.
Toxicologic and Inhibitory Receptor Actions of the Etomidate Analog ABP-700 and Its Metabolite CPM-Acid.
Edward Mallinckrodt Jr. Professor of Anaesthesia in the Field of Pharmacology and Innovation
Warren M. Zapol Professor of Anaesthesia
Edith M. Ashley Professor of Orthopedic Surgery, Emeritus
Bullard Professor of Neurobiology, Emeritus
Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats. BMC Pharmacol Toxicol. 2019 08 05; 20(1):48.
Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats.
Computational Approaches to Anesthetic Drug Discovery. Trends Pharmacol Sci. 2019 11; 40(11):809-811.
Computational Approaches to Anesthetic Drug Discovery.
The effects of a competitive antagonist on GABA-evoked currents in the presence of sedative-hypnotic agents. Pharmacol Rep. 2020 Feb; 72(1):260-266.
The effects of a competitive antagonist on GABA-evoked currents in the presence of sedative-hypnotic agents.
McGrath M, Hoyt H, Pence A, Jayakar SS, Zhou X, Forman SA, Cohen JB, Miller KW, Raines DE
Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABAA Receptor and In Vivo Zebrafish Studies. Anesthesiology. 2020 09; 133(3):583-594.
Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABAA Receptor and In Vivo Zebrafish Studies.
Competitive Antagonism of Etomidate Action by Diazepam. Anesthesiology. 2020 09 01; 133(3):583-594.
Competitive Antagonism of Etomidate Action by Diazepam.
Journal of cardiothoracic and vascular anesthesia
Etomidate and Adrenocortical Suppression: Should We Take the Concerns to Heart? J Cardiothorac Vasc Anesth. 2021 04; 35(4):1086-1088.
Etomidate and Adrenocortical Suppression: Should We Take the Concerns to Heart?
McGrath M, Hoyt H, Pence A, Forman SA, Raines DE
Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABAA receptor: In vitro and in vivo studies. Br J Pharmacol. 2021 12; 178(24):4842-4858.
Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABAA receptor: In vitro and in vivo studies.
Therapeutic advances in endocrinology and metabolism
Pharmacological management of severe Cushing's syndrome: the role of etomidate. Ther Adv Endocrinol Metab. 2022; 13:20420188211058583.
Pharmacological management of severe Cushing's syndrome: the role of etomidate.
Pence A, Hoyt H, McGrath M, Forman SA, Raines DE
Competitive Interactions Between Propofol and Diazepam: Studies in GABAA Receptors and Zebrafish. J Pharmacol Exp Ther. 2022 12; 383(3):238-245.
Competitive Interactions Between Propofol and Diazepam: Studies in GABAA Receptors and Zebrafish.
Anesthetic drug development: Novel drugs and new approaches. Surg Neurol Int. 2013; 4(Suppl 1):S2-S10.
Anesthetic drug development: Novel drugs and new approaches.
Shanmugasundararaj S, Zhou X, Neunzig J, Bernhardt R, Cotten JF, Ge R, Miller KW, Raines DE
Carboetomidate: an analog of etomidate that interacts weakly with 11ß-hydroxylase. Anesth Analg. 2013 Jun; 116(6):1249-56.
Carboetomidate: an analog of etomidate that interacts weakly with 11ß-hydroxylase.
Ge R, Pejo E, Gallin H, Jeffrey S, Cotten JF, Raines DE
The pharmacology of cyclopropyl-methoxycarbonyl metomidate: a comparison with propofol. Anesth Analg. 2014 Mar; 118(3):563-7.
The pharmacology of cyclopropyl-methoxycarbonyl metomidate: a comparison with propofol.
Pejo E, Santer P, Jeffrey S, Gallin H, Husain SS, Raines DE
Analogues of etomidate: modifications around etomidate's chiral carbon and the impact on in vitro and in vivo pharmacology. Anesthesiology. 2014 Aug; 121(2):290-301.
Analogues of etomidate: modifications around etomidate's chiral carbon and the impact on in vitro and in vivo pharmacology.
Adrenocortical suppression and recovery after continuous hypnotic infusion: etomidate versus its soft analogue cyclopropyl-methoxycarbonyl metomidate. Crit Care. 2013 Jan 30; 17(1):R20.
Adrenocortical suppression and recovery after continuous hypnotic infusion: etomidate versus its soft analogue cyclopropyl-methoxycarbonyl metomidate.
Campagna JA, Pojasek K, Grayzel D, Randle J, Raines DE
Advancing novel anesthetics: pharmacodynamic and pharmacokinetic studies of cyclopropyl-methoxycarbonyl metomidate in dogs. Anesthesiology. 2014 Dec; 121(6):1203-16.
Advancing novel anesthetics: pharmacodynamic and pharmacokinetic studies of cyclopropyl-methoxycarbonyl metomidate in dogs.
Santer P, Pejo E, Feng Y, Chao W, Raines DE
Cyclopropyl-methoxycarbonyl Metomidate: Studies in a Lipopolysaccharide Inflammatory Model of Sepsis. Anesthesiology. 2015 Aug; 123(2):368-76.
Cyclopropyl-methoxycarbonyl Metomidate: Studies in a Lipopolysaccharide Inflammatory Model of Sepsis.
Total Intravenous Anesthesia Using N-Methyl-D-Aspartate (NMDA) Receptor-Sparing Drugs in a Patient with Anti-NMDA Receptor Encephalitis. A A Case Rep. 2014 Apr 01; 2(7):83-5.
Total Intravenous Anesthesia Using N-Methyl-D-Aspartate (NMDA) Receptor-Sparing Drugs in a Patient with Anti-NMDA Receptor Encephalitis.
The pharmacology of etomidate and etomidate derivatives. Int Anesthesiol Clin. 2015; 53(2):63-75.
The pharmacology of etomidate and etomidate derivatives.
Desai R, Savechenkov PY, Zolkowska D, Ge RL, Rogawski MA, Bruzik KS, Forman SA, Raines DE, Miller KW
Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the a1 ß3 ?2L GABAA receptor account for their in vivo effects. J Physiol. 2015 Nov 15; 593(22):4943-61.
Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the a1 ß3 ?2L GABAA receptor account for their in vivo effects.
Pejo E, Santer P, Wang L, Dershwitz P, Husain SS, Raines DE
?-Aminobutyric Acid Type A Receptor Modulation by Etomidate Analogs. Anesthesiology. 2016 Mar; 124(3):651-63.
?-Aminobutyric Acid Type A Receptor Modulation by Etomidate Analogs.
Distinct Hypnotic Recoveries After Infusions of Methoxycarbonyl Etomidate and Cyclopropyl Methoxycarbonyl Metomidate: The Role of the Metabolite. Anesth Analg. 2016 Apr; 122(4):1008-14.
Distinct Hypnotic Recoveries After Infusions of Methoxycarbonyl Etomidate and Cyclopropyl Methoxycarbonyl Metomidate: The Role of the Metabolite.
Etomidate Analogues as Safer General Anesthetics
GENERAL ANESTHETICS AND LIPID PROTEIN INTERACTIONS
General Anesthetics and nAcCHOR Agonist Affinity
Preclinical Studies of Carbo-etomidate: An Etomidate Analogue for Use in Sepsis
Sedative-hypnotic Binding to 11ß-hydroxylase. Anesthesiology. 2016 11; 125(5):943-951.
Sedative-hypnotic Binding to 11ß-hydroxylase.
Flumazenil Modulation of the ?-Aminobutyric Acid Type A Receptor: Competitive versus Noncompetitive Antagonism at the Agonist-binding Site. Anesthesiology. 2017 02; 126(2):350-351.
Flumazenil Modulation of the ?-Aminobutyric Acid Type A Receptor: Competitive versus Noncompetitive Antagonism at the Agonist-binding Site.
Anesthetic management and outcome following noncardiac surgery in nonparturients with Eisenmenger's physiology. J Clin Anesth. 1996 Aug; 8(5):341-7.
Anesthetic management and outcome following noncardiac surgery in nonparturients with Eisenmenger's physiology.
Halothane interactions with nicotinic acetylcholine receptor membranes. Steady-state and kinetic studies of intrinsic fluorescence quenching. Anesthesiology. 1997 Feb; 86(2):476-86.
Halothane interactions with nicotinic acetylcholine receptor membranes. Steady-state and kinetic studies of intrinsic fluorescence quenching.
Perturbation of lipid and protein structure by general anesthetics: how little is too little? Anesthesiology. 2000 May; 92(5):1492-4.
Perturbation of lipid and protein structure by general anesthetics: how little is too little?
Eger EI, Gong D, Xing Y, Raines DE, Flood P
Acetylcholine receptors and thresholds for convulsions from flurothyl and 1,2-dichlorohexafluorocyclobutane. Anesth Analg. 2002 Dec; 95(6):1611-5, table of contents.
Acetylcholine receptors and thresholds for convulsions from flurothyl and 1,2-dichlorohexafluorocyclobutane.
The alkyl chain dependence of the effect of normal alcohols on agonist-induced nicotinic acetylcholine receptor desensitization kinetics. Anesthesiology. 1999 Jul; 91(1):222-30.
The alkyl chain dependence of the effect of normal alcohols on agonist-induced nicotinic acetylcholine receptor desensitization kinetics.
Raines DE, Hogue CW, Wickens C, Welch J, Risk SC
Artifactual hypertension due to transducer cable malfunction. Anesthesiology. 1991 Jun; 74(6):1149-51.
Artifactual hypertension due to transducer cable malfunction.
Raines DE, Gioia F, Claycomb RJ, Stevens RJ
The N-methyl-D-aspartate receptor inhibitory potencies of aromatic inhaled drugs of abuse: evidence for modulation by cation-pi interactions. J Pharmacol Exp Ther. 2004 Oct; 311(1):14-21.
The N-methyl-D-aspartate receptor inhibitory potencies of aromatic inhaled drugs of abuse: evidence for modulation by cation-pi interactions.
Agonist binding and affinity state transitions in reconstituted nicotinic acetylcholine receptors revealed by single and sequential mixing stopped-flow fluorescence spectroscopies. Biochim Biophys Acta. 1998 Sep 23; 1374(1-2):83-93.
Agonist binding and affinity state transitions in reconstituted nicotinic acetylcholine receptors revealed by single and sequential mixing stopped-flow fluorescence spectroscopies.
NMDA receptor inhibitory potencies of volatile aromatic anesthetics: the role of cation-pi interactions. Anesthesiology. 2003; A-109.
NMDA receptor inhibitory potencies of volatile aromatic anesthetics: the role of cation-pi interactions
Snyder SW, Raines DE, Rieger PT, Demas DN, Degraff BA
Luminescence quenching of Ruthenium (II) photosynthesizers by Cu (II) in triton surfactant media. Langmuir. 1985; 1:548-52.
Luminescence quenching of Ruthenium (II) photosynthesizers by Cu (II) in triton surfactant media
Stevens RJ, Rusch D, Davies PA, Raines DE
Modulation of 5-HT3A receptors by n-alcohols and volatile anesthetics is dependent on molecular volume. Biophysical Journal. 2004.
Modulation of 5-HT3A receptors by n-alcohols and volatile anesthetics is dependent on molecular volume
Modulation of GABA(A) receptor function by nonhalogenated alkane anesthetics: the effects on agonist enhancement, direct activation, and inhibition. Anesth Analg. 2003 Jan; 96(1):112-8, table of contents.
Modulation of GABA(A) receptor function by nonhalogenated alkane anesthetics: the effects on agonist enhancement, direct activation, and inhibition.
Cogswell LP, Raines DE, Parekh S, Jonas O, Maggio JE, Strichartz GR
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Development of a novel probe for measuring drug binding to the F1*S variant of human alpha 1-acid glycoprotein.
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Increases in spinal cerebrospinal fluid potassium concentration do not increase isoflurane minimum alveolar concentration in rats.
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Aprotinin administration and pulmonary thromboembolism during orthotopic liver transplantation: report of two cases. Anesth Analg. 2001 Jun; 92(6):1418-21.
Aprotinin administration and pulmonary thromboembolism during orthotopic liver transplantation: report of two cases.
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Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration. Anesth Analg. 2003 Sep; 97(3):718-740.
Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration.
Solt K, Ruesch D, Forman SA, Davies PA, Raines DE
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Differential effects of serotonin and dopamine on human 5-HT3A receptor kinetics: interpretation within an allosteric kinetic model. J Neurosci. 2007 Nov 28; 27(48):13151-60.
Differential effects of serotonin and dopamine on human 5-HT3A receptor kinetics: interpretation within an allosteric kinetic model.
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Automated documentation error detection and notification improves anesthesia billing performance. Anesthesiology. 2007 Jan; 106(1):157-63.
Automated documentation error detection and notification improves anesthesia billing performance.
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Isoflurane increases the apparent agonist affinity of the nicotinic acetylcholine receptor.
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Is a new paradigm needed to explain how inhaled anesthetics produce immobility?
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Competitive Antagonism of Anesthetic Action at the ?-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy. Anesthesiology. 2017 11; 127(5):824-837.
Competitive Antagonism of Anesthetic Action at the ?-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy.
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Effects of Etomidate and Photoactivatable Etomidate Analogues on Adrenal Cortisol Synthesis
Competitive Antagonists for General Anesthetics: A New Class of Drugs for Improving Patient Care and Advancing Scientific Research
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Anesthetic management for transurethral resection of the bladder in a 74-year-old man with uncorrected tetralogy of Fallot. J Clin Anesth. 2005 May; 17(3):198-201.
Anesthetic management for transurethral resection of the bladder in a 74-year-old man with uncorrected tetralogy of Fallot.
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MOC-etomidate: A Novel, Rapidly Metabolized and Ultra-Short-Acting Etomidate Analogue
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Contrasting effects of NMDA receptor inhibition by MK-801 on the immobilizing potencies of aromatic and non-aromatic inhaled anesthetics
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Nonhalogenated alkane anesthetics fail to potentiate agonist actions on two ligand-gated ion channels.
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Nonhalogenated anesthetic alkanes and perhalogenated nonimmobilizing alkanes inhibit alpha(4)beta(2) neuronal nicotinic acetylcholine receptors.
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The role of electrostatic interactions in governing anesthetic action on the torpedo nicotinic acetylcholine receptor.
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Modulation of human NMDA receptors by chemically diverse general anesthetics: differential inhibition at 1 MAC
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Modulation of human 5-hydroxytryptamine type 3AB receptors by volatile anesthetics and n-alcohols.
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Development of a novel probe of drug-protein interactions
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Association of University Anesthesiologists
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Dimethoxy-etomidate: A Nonhypnotic Etomidate Analog that Potently Inhibits Steroidogenesis.
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Sources of Variation in Anesthetic Drug Costs. Anesth Analg. 2018 04; 126(4):1241-1248.
Sources of Variation in Anesthetic Drug Costs.
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General anesthetic-induced channel gating enhancement of 5-hydroxytryptamine type 3 receptors depends on receptor subunit composition.
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Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels.
Modifying methoxycarbonyl etomidate inter-ester spacer optimizes in vitro metabolic stability and in vivo hypnotic potency and duration of action. Anesthesiology. 2012 Nov; 117(5):1027-36.
Modifying methoxycarbonyl etomidate inter-ester spacer optimizes in vitro metabolic stability and in vivo hypnotic potency and duration of action.
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General anesthethetic action on 5-HT3 receptors: influence of subunit composition
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Nonanesthetic volatile drugs obey the Meyer-Overton correlation in two molecular protein site models.