Raines, Douglas
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first name: Douglas
last name: Raines
coauthor of: Miller, Keith
coauthor of: Forman, Stuart
coauthor of: Cotten, Joseph
coauthor of: Solt, Ken
coauthor of: Cohen, Jonathan
full name: Douglas Eric Raines, M.D.
has faculty rank: Full Professor
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photo: https://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 18942
person in primary position: Edward Mallinckrodt, Jr. Professor of Anaesthesia in the Field Pharmacology and Innovation, Emeritus
physical neighbor: Novelline, Robert
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similar to: Forman, Stuart
similar to: Cohen, Jonathan
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selected publications: Authorship 1499768
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selected publications: Authorship 599559

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Comparison of the molecular bases for NMDA-receptor inhibition versus immobilizing activities of volatile aromatic anesthetics
author list: Sewell JC, Raines DE, Laster M, Eger EI, Sear JW
published in: Anesth Analg
information resource reference: Comparison of the molecular bases for NMDA-receptor inhibition versus immobilizing activities of volatile aromatic anesthetics. Anesth Analg. 2008; in press.
publication date: 2008-10-15T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Lipids modulate ethanol-induced desensitization of nicotinic acetylcholine receptors
author list: Raines DE, Miller KW
published in: Annual Meeting of the Research Society on Alcoholism
information resource reference: Lipids modulate ethanol-induced desensitization of nicotinic acetylcholine receptors. Annual Meeting of the Research Society on Alcoholism. 1995.
publication date: 1995-01-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Spin-label studies into the effects of ethanol on lipid- protein interactions in reconstituted acetylcholine receptor vesicles
author list: Raines DE, Miller KW
published in: Biophysical Journal
information resource reference: Spin-label studies into the effects of ethanol on lipid- protein interactions in reconstituted acetylcholine receptor vesicles. Biophysical Journal. 1993.
publication date: 1993-01-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

The kinetics of halothane interactions with nicotinic acetylcholine receptor membranes: stopped-flow studies of intrinsic fluorescence quenching
author list: Raines DE, McClure KB
published in: Anesthesiology
information resource reference: The kinetics of halothane interactions with nicotinic acetylcholine receptor membranes: stopped-flow studies of intrinsic fluorescence quenching. Anesthesiology. 1996.
publication date: 1996-01-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Anesthetic cutoff in cycloalkanemethanols. A test of current theories.
PubMed Identifier: 8489064
author list: Raines DE, Korten SE, Hill AG, Miller KW
published in: Anesthesiology
information resource reference: Anesthetic cutoff in cycloalkanemethanols. A test of current theories. Anesthesiology. 1993 May; 78(5):918-27.
journal title abbreviation: Anesthesiology
publication date: 1993-05-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1058837
type: Authorship
author rank in publication: 2
linked author: Raines, Douglas
linked information resource: Anesthetic Drug Discovery and Development: A Case Study of Novel Etomidate Analogs.

Anesthetic Drug Discovery and Development: A Case Study of Novel Etomidate Analogs.
PubMed Identifier: 29673523
author list: McGrath M, Raines DE
published in: Methods in enzymology
information resource reference: Anesthetic Drug Discovery and Development: A Case Study of Novel Etomidate Analogs. Methods Enzymol. 2018; 603:153-169.
journal title abbreviation: Methods Enzymol
publication date: 2018-03-02T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

In vivo and in vitro pharmacological studies of methoxycarbonyl-carboetomidate.
PubMed Identifier: 21965364
author list: Pejo E, Cotten JF, Kelly EW, Le Ge R, Cuny GD, Laha JK, Liu J, Lin XJ, Raines DE
published in: Anesthesia and analgesia
information resource reference: In vivo and in vitro pharmacological studies of methoxycarbonyl-carboetomidate. Anesth Analg. 2012 Aug; 115(2):297-304.
journal title abbreviation: Anesth Analg
publication date: 2011-09-29T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Anesthesia for Liver Surgery and Transplantation
author list: Sandberg WS, Raines DE
published in: Longnecker D., Brown D., Newman M., and Zapol W., Eds., Principles and Practice of Anesthesiology,
information resource reference: Anesthesia for Liver Surgery and Transplantation. Longnecker D., Brown D., Newman M., and Zapol W., Eds., Principles and Practice of Anesthesiology,. 2007; 1338-1377.
publication date: 2007-05-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

The Variable Effects of Volatile Aromatic Anesthetics on GABA A Receptor Function
author list: Solt K, Kelly EW, Raines DE
published in: Anesthesiology
information resource reference: The Variable Effects of Volatile Aromatic Anesthetics on GABA A Receptor Function. Anesthesiology. 2007; A8.
publication date: 2007-10-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Electron spin resonance studies of acyl chain motion in reconstituted nicotinic acetylcholine receptor membranes.
PubMed Identifier: 8527664
author list: Raines DE, Wu G, Dalton LA, Miller KW
published in: Biophysical journal
information resource reference: Electron spin resonance studies of acyl chain motion in reconstituted nicotinic acetylcholine receptor membranes. Biophys J. 1995 Aug; 69(2):498-505.
journal title abbreviation: Biophys J
publication date: 1995-08-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhibition of human 5-HT(3A) and 5-HT(3AB) receptors by etomidate, propofol and pentobarbital.
PubMed Identifier: 17669396
author list: Rüsch D, Braun HA, Wulf H, Schuster A, Raines DE
published in: European journal of pharmacology
information resource reference: Inhibition of human 5-HT(3A) and 5-HT(3AB) receptors by etomidate, propofol and pentobarbital. Eur J Pharmacol. 2007 Nov 14; 573(1-3):60-4.
journal title abbreviation: Eur J Pharmacol
publication date: 2007-07-13T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Do N-methyl-D-aspartate receptors mediate the capacity of inhaled anesthetics to suppress the temporal summation that contributes to minimum alveolar concentration?
PubMed Identifier: 16632819
author list: Dutton RC, Laster MJ, Xing Y, Sonner JM, Raines DE, Solt K, Eger EI
published in: Anesthesia and analgesia
information resource reference: Do N-methyl-D-aspartate receptors mediate the capacity of inhaled anesthetics to suppress the temporal summation that contributes to minimum alveolar concentration? Anesth Analg. 2006 May; 102(5):1412-8.
journal title abbreviation: Anesth Analg
publication date: 2006-05-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Lipid disordering predicts anesthetic cutoff in cycloalkanemethanols
author list: Raines DE, Kortin SE, Hill WAG, Miller KW
published in: Anesthesiology
information resource reference: Lipid disordering predicts anesthetic cutoff in cycloalkanemethanols. Anesthesiology. 1992; 2:757.
publication date: 1992-01-01T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

Photosensitivity and perioperative polyneuropathy complicating orthotopic liver transplantation in a patient with erythropoietic protoporphyria.
PubMed Identifier: 10519521
author list: Nguyen L, Blust M, Bailin M, Melendez L, Raines DE
published in: Anesthesiology
information resource reference: Photosensitivity and perioperative polyneuropathy complicating orthotopic liver transplantation in a patient with erythropoietic protoporphyria. Anesthesiology. 1999 Oct; 91(4):1173-5.
journal title abbreviation: Anesthesiology
publication date: 1999-10-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Intra-anesthetic Problems
author list: Raines DE, Chang BS-P, Patafio O
published in: Clinical Anesthesia Procedures of the Massachusetts General Hospital
information resource reference: Intra-anesthetic Problems. Clinical Anesthesia Procedures of the Massachusetts General Hospital. 1993.
publication date: 1993-01-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Anesthetic Action on the Nicotinic Acetylcholine Receptor
author list: Forman SA, Flood P, Raines DE
published in: Neural Mechanisms of Anesthesia
information resource reference: Anesthetic Action on the Nicotinic Acetylcholine Receptor. Neural Mechanisms of Anesthesia. 2002; 283-298.
publication date: 2002-01-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Closed-loop continuous infusions of etomidate and etomidate analogs in rats: a comparative study of dosing and the impact on adrenocortical function.
PubMed Identifier: 21572317
author list: Cotten JF, Le Ge R, Banacos N, Pejo E, Husain SS, Williams JH, Raines DE
published in: Anesthesiology
information resource reference: Closed-loop continuous infusions of etomidate and etomidate analogs in rats: a comparative study of dosing and the impact on adrenocortical function. Anesthesiology. 2011 Oct; 115(4):764-73.
journal title abbreviation: Anesthesiology
publication date: 2011-10-01T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Electroencephalographic and hypnotic recoveries after brief and prolonged infusions of etomidate and optimized soft etomidate analogs.
PubMed Identifier: 22929726
author list: Ge R, Pejo E, Husain SS, Cotten JF, Raines DE
published in: Anesthesiology
information resource reference: Electroencephalographic and hypnotic recoveries after brief and prolonged infusions of etomidate and optimized soft etomidate analogs. Anesthesiology. 2012 Nov; 117(5):1037-43.
journal title abbreviation: Anesthesiology
publication date: 2012-11-01T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Azo-propofols: photochromic potentiators of GABA(A) receptors.
PubMed Identifier: 22968919
author list: Stein M, Middendorp SJ, Carta V, Pejo E, Raines DE, Forman SA, Sigel E, Trauner D
published in: Angewandte Chemie (International ed. in English)
information resource reference: Azo-propofols: photochromic potentiators of GABA(A) receptors. Angew Chem Int Ed Engl. 2012 Oct 15; 51(42):10500-4.
journal title abbreviation: Angew Chem Int Ed Engl
publication date: 2012-09-11T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Gamma-aminobutyric acidA receptors do not mediate the immobility produced by isoflurane.
PubMed Identifier: 15281509
author list: Zhang Y, Sonner JM, Eger EI, Stabernack CR, Laster MJ, Raines DE, Harris RA
published in: Anesthesia and analgesia
information resource reference: Gamma-aminobutyric acidA receptors do not mediate the immobility produced by isoflurane. Anesth Analg. 2004 Jul; 99(1):85-90.
journal title abbreviation: Anesth Analg
publication date: 2004-07-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Cation-pi interactions modulate the NMDA receptor potencies of inhaled aromatic anesthetics
author list: Raines DE
published in: International Congress Series
information resource reference: Cation-pi interactions modulate the NMDA receptor potencies of inhaled aromatic anesthetics. International Congress Series. 2005; 85-9.
publication date: 2005-01-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Isoflurane Accelerates the Activation and Deactivation Rates of Human 5-HT3A Receptors
author list: Solt, K, Ruesch D, Davies P, Raines DE
published in: Anesthesiology
information resource reference: Isoflurane Accelerates the Activation and Deactivation Rates of Human 5-HT3A Receptors. Anesthesiology. 2006; A174.
publication date: 2006-10-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Volatile anesthetics enhance the open probability of 5-HT3A channels
author list: Stevens RS, Rusch D, Solt K, Raines DE, Davies PA
information resource reference: Volatile anesthetics enhance the open probability of 5-HT3A channels. 2004; A-584.
publication date: 2004-01-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol.
PubMed Identifier: 22029276
author list: Stewart DS, Savechenkov PY, Dostalova Z, Chiara DC, Ge R, Raines DE, Cohen JB, Forman SA, Bruzik KS, Miller KW
published in: Journal of medicinal chemistry
information resource reference: p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol. J Med Chem. 2011 Dec 08; 54(23):8124-35.
journal title abbreviation: J Med Chem
publication date: 2011-11-10T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1085131
type: Authorship
author rank in publication: 9
linked author: Raines, Douglas
linked information resource: Etomidate and Etomidate Analog Binding and Positive Modulation of ?-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect.

Etomidate and Etomidate Analog Binding and Positive Modulation of ?-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect.
PubMed Identifier: 30052529
author list: McGrath M, Yu Z, Jayakar SS, Ma C, Tolia M, Zhou X, Miller KW, Cohen JB, Raines DE
published in: Anesthesiology
information resource reference: Etomidate and Etomidate Analog Binding and Positive Modulation of ?-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect. Anesthesiology. 2018 11; 129(5):959-969.
journal title abbreviation: Anesthesiology
publication date: 2018-11-01T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Electron Spin Resonance (ESR) studies into the origin of selectivity for negatively charged lipids at the lipid-protein interface of the nicotinic acetylcholine receptor
author list: Raines DE, Miller KW
published in: The Pharmacologist
information resource reference: Electron Spin Resonance (ESR) studies into the origin of selectivity for negatively charged lipids at the lipid-protein interface of the nicotinic acetylcholine receptor. The Pharmacologist. 1992; 34(3):296.
publication date: 1992-01-01T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

A comparison of the molecular bases for N-methyl-D-aspartate-receptor inhibition versus immobilizing activities of volatile aromatic anesthetics.
PubMed Identifier: 19095845
author list: Sewell JC, Raines DE, Eger EI, Laster MJ, Sear JW
published in: Anesthesia and analgesia
information resource reference: A comparison of the molecular bases for N-methyl-D-aspartate-receptor inhibition versus immobilizing activities of volatile aromatic anesthetics. Anesth Analg. 2009 Jan; 108(1):168-75.
journal title abbreviation: Anesth Analg
publication date: 2009-01-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 102083
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: The N-methyl-D-aspartate receptor inhibitory potencies of aromatic inhaled drugs of abuse: evidence for modulation by cation-pi interactions.

Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression.
PubMed Identifier: 19625798
author list: Cotten JF, Husain SS, Forman SA, Miller KW, Kelly EW, Nguyen HH, Raines DE
published in: Anesthesiology
information resource reference: Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression. Anesthesiology. 2009 Aug; 111(2):240-9.
journal title abbreviation: Anesthesiology
publication date: 2009-08-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia.
PubMed Identifier: 21926608
author list: Pejo E, Feng Y, Chao W, Cotten JF, Le Ge R, Raines DE
published in: Critical care medicine
information resource reference: Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia. Crit Care Med. 2012 Jan; 40(1):187-92.
journal title abbreviation: Crit Care Med
publication date: 2012-01-01T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Introduction of the 5-HT3B subunit decreases the sensitivity of 5-HT3A receptors to the potentiating actions of general anesthetics
author list: Solt K, Davies P, Stevens R, Rusch D, Raines DE
published in: Anesthesiology
information resource reference: Introduction of the 5-HT3B subunit decreases the sensitivity of 5-HT3A receptors to the potentiating actions of general anesthetics. Anesthesiology. 2004; A-107.
publication date: 2004-01-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats.
PubMed Identifier: 18633026
author list: Eger EI, Tang M, Liao M, Laster MJ, Solt K, Flood P, Jenkins A, Raines D, Hendrickx JF, Shafer SL, Yasumasa T, Sonner JM
published in: Anesthesia and analgesia
information resource reference: Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats. Anesth Analg. 2008 Aug; 107(2):479-85.
journal title abbreviation: Anesth Analg
publication date: 2008-08-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.
PubMed Identifier: 22734650
author list: Savechenkov PY, Zhang X, Chiara DC, Stewart DS, Ge R, Zhou X, Raines DE, Cohen JB, Forman SA, Miller KW, Bruzik KS
published in: Journal of medicinal chemistry
information resource reference: Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic. J Med Chem. 2012 Jul 26; 55(14):6554-65.
journal title abbreviation: J Med Chem
publication date: 2012-07-17T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

The Future of Anesthetic Mechanisms Research
author list: Antognini JF, and Raines DE, Carstens EE
published in: Neural Mechanisms of Anesthesia
information resource reference: The Future of Anesthetic Mechanisms Research. Neural Mechanisms of Anesthesia. 2002; 449-453.
publication date: 2002-01-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Nonanesthetic Haloalkanes and Nicotinic Acetylcholine Receptor Desensitization Kinetics
author list: Raines DE
published in: Anesthesiology
information resource reference: Nonanesthetic Haloalkanes and Nicotinic Acetylcholine Receptor Desensitization Kinetics. Anesthesiology. 1996; 85:431-432.
publication date: 1996-01-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

The 5-HT3B subunit influences 5-HT3 receptor kinetics and pharmacology
author list: Feinberg-Zadek PL, Rusch D, Solt K, Raines DE, Davies PA
published in: 35th annual meeting for the Society for Neurosciences
information resource reference: The 5-HT3B subunit influences 5-HT3 receptor kinetics and pharmacology. 35th annual meeting for the Society for Neurosciences. 2005.
publication date: 2005-11-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular properties important for inhaled anesthetic action on human 5-HT3A receptors.
PubMed Identifier: 15920198
author list: Stevens RJN, Rüsch D, Davies PA, Raines DE
published in: Anesthesia and analgesia
information resource reference: Molecular properties important for inhaled anesthetic action on human 5-HT3A receptors. Anesth Analg. 2005 Jun; 100(6):1696-1703.
journal title abbreviation: Anesth Analg
publication date: 2005-06-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Subunit-dependent modulation of the 5-hydroxytryptamine type 3 receptor open-close equilibrium by n-alcohols.
PubMed Identifier: 17360702
author list: Rüsch D, Musset B, Wulf H, Schuster A, Raines DE
published in: The Journal of pharmacology and experimental therapeutics
information resource reference: Subunit-dependent modulation of the 5-hydroxytryptamine type 3 receptor open-close equilibrium by n-alcohols. J Pharmacol Exp Ther. 2007 Jun; 321(3):1069-74.
journal title abbreviation: J Pharmacol Exp Ther
publication date: 2007-03-07T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 128804
type: Authorship
author rank in publication: 6
linked author: Raines, Douglas
linked information resource: Gamma-aminobutyric acidA receptors do not mediate the immobility produced by isoflurane.

Kinetics of anesthetic-induced conformational transitions in a four-alpha-helix bundle protein
author list: Solt K, Johansson JS, Raines DE
published in: 53rd Annual Meeting of the Association of University
information resource reference: Kinetics of anesthetic-induced conformational transitions in a four-alpha-helix bundle protein. 53rd Annual Meeting of the Association of University. 2006.
publication date: 2006-05-11T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhibition of alpha4beta2 rat neuronal nicotinic receptors by nonhalogenated alkane anesthetics and perhalogenated alkane nonimmobilizers
author list: Claycomb, RJ, Forman, SA, and Raines DE
published in: Molecular and Basic Mechanisms of Anesthesia
information resource reference: Inhibition of alpha4beta2 rat neuronal nicotinic receptors by nonhalogenated alkane anesthetics and perhalogenated alkane nonimmobilizers. Molecular and Basic Mechanisms of Anesthesia. 2002; 115-119.
publication date: 2002-01-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

General anesthetics modify the kinetics of nicotinic acetylcholine receptor desensitization at clinically relevant concentrations.
PubMed Identifier: 7832311
author list: Raines DE, Rankin SE, Miller KW
published in: Anesthesiology
information resource reference: General anesthetics modify the kinetics of nicotinic acetylcholine receptor desensitization at clinically relevant concentrations. Anesthesiology. 1995 Jan; 82(1):276-87; discussion 31A-32A.
journal title abbreviation: Anesthesiology
publication date: 1995-01-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Volatile anesthetics reduce the agonist EC50 of the human 5-HT3A receptor by increasing channel gating probability
author list: Solt K, Davies P, Stevens R, Rusch D, Raines DE
published in: Anesthesiology
information resource reference: Volatile anesthetics reduce the agonist EC50 of the human 5-HT3A receptor by increasing channel gating probability. Anesthesiology. 2004; A-106.
publication date: 2004-01-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

The fluorescent agonist Dns-C6-Cho binds with micromolar affinity to the alpha-delta binding site of the nicotinic acetylcholine receptor resting state
author list: Raines DE, Zachariah ZT
published in: Biophysical Journal
information resource reference: The fluorescent agonist Dns-C6-Cho binds with micromolar affinity to the alpha-delta binding site of the nicotinic acetylcholine receptor resting state. Biophysical Journal. 1999.
publication date: 1999-01-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Lipid-protein interactions and protein dynamics in vesicles containing the nicotinic acetylcholine receptor: a study with ethanol.
PubMed Identifier: 8075138
author list: Abadji V, Raines DE, Dalton LA, Miller KW
published in: Biochimica et biophysica acta
information resource reference: Lipid-protein interactions and protein dynamics in vesicles containing the nicotinic acetylcholine receptor: a study with ethanol. Biochim Biophys Acta. 1994 Aug 24; 1194(1):25-34.
journal title abbreviation: Biochim Biophys Acta
publication date: 1994-08-24T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 139211
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: Agonist binding and affinity state transitions in reconstituted nicotinic acetylcholine receptors revealed by single and sequential mixing stopped-flow fluorescence spectroscopies.

The effect of general anesthetics on the dynamics of phosphatidylcholine-acetylcholine receptor interactions in reconstituted vesicles.
PubMed Identifier: 8466926
author list: Abadji VC, Raines DE, Watts A, Miller KW
published in: Biochimica et biophysica acta
information resource reference: The effect of general anesthetics on the dynamics of phosphatidylcholine-acetylcholine receptor interactions in reconstituted vesicles. Biochim Biophys Acta. 1993 Apr 08; 1147(1):143-53.
journal title abbreviation: Biochim Biophys Acta
publication date: 1993-04-08T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

The pyrrole etomidate analog carboetomidate potently inhibits human 5-HT3A receptor function: comparisons with etomidate and potential implications for emetogenesis.
PubMed Identifier: 23400978
author list: Desai R, Miller KW, Raines DE
published in: Anesthesia and analgesia
information resource reference: The pyrrole etomidate analog carboetomidate potently inhibits human 5-HT3A receptor function: comparisons with etomidate and potential implications for emetogenesis. Anesth Analg. 2013 Mar; 116(3):573-9.
journal title abbreviation: Anesth Analg
publication date: 2013-02-11T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Improving billing effectiveness with automated anesthesia information management
author list: Sandberg WS, Spring SF, Anupama S, Raines DE
published in: Anesthesiology
information resource reference: Improving billing effectiveness with automated anesthesia information management. Anesthesiology. 2006.
publication date: 2006-07-10T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Intra-anesthetic Problems
author list: Baker K, Raines DE
published in: Clinical Anesthesia Procedures of the Massachusetts General Hospital
information resource reference: Intra-anesthetic Problems. Clinical Anesthesia Procedures of the Massachusetts General Hospital. 2002.
publication date: 2002-01-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Isoflurane's actions on the nicotinic acetylcholine receptor are dependent upon the composition of the lipid bilayer
author list: Raines DE, Rankin SE, Miller KW
published in: Anesthesiology
information resource reference: Isoflurane's actions on the nicotinic acetylcholine receptor are dependent upon the composition of the lipid bilayer. Anesthesiology. 1994.
publication date: 1994-01-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Conformational transitions of the nicotinic acetylcholine receptor as a model for anesthetic actions on ligand-gated ion channels: single and sequential mixing stopped-flow fluorescence studies
author list: Raines DE
published in: Molecular and Cellular Mechanisms of General Anesthesia
information resource reference: Conformational transitions of the nicotinic acetylcholine receptor as a model for anesthetic actions on ligand-gated ion channels: single and sequential mixing stopped-flow fluorescence studies. Molecular and Cellular Mechanisms of General Anesthesia. 1998; 100-101:163-168.
publication date: 1998-01-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

The Interactions of General Anesthetics with Membranes
author list: Forman SA, Raines DE, Miller KW
published in: Anesthesia: Biologic Foundations
information resource reference: The Interactions of General Anesthetics with Membranes. Anesthesia: Biologic Foundations. 1994; 5-18.
publication date: 1994-01-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

General anesthetic effects on nicotinic acetylcholine receptor conformational states are dependent upon lipid composition
author list: Raines DE, Rankin SE, Miller, KW
published in: 41st Annual Meeting of the Association of University
information resource reference: General anesthetic effects on nicotinic acetylcholine receptor conformational states are dependent upon lipid composition. 41st Annual Meeting of the Association of University. 1994.
publication date: 1994-01-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function.
PubMed Identifier: 20179500
author list: Cotten JF, Forman SA, Laha JK, Cuny GD, Husain SS, Miller KW, Nguyen HH, Kelly EW, Stewart D, Liu A, Raines DE
published in: Anesthesiology
information resource reference: Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function. Anesthesiology. 2010 Mar; 112(3):637-44.
journal title abbreviation: Anesthesiology
publication date: 2010-03-01T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Carboetomidate inhibits alpha4/beta2 neuronal nicotinic acetylcholine receptors at concentrations affecting animals.
PubMed Identifier: 22543065
author list: Pierce DW, Pejo E, Raines DE, Forman SA
published in: Anesthesia and analgesia
information resource reference: Carboetomidate inhibits alpha4/beta2 neuronal nicotinic acetylcholine receptors at concentrations affecting animals. Anesth Analg. 2012 Jul; 115(1):70-2.
journal title abbreviation: Anesth Analg
publication date: 2012-04-27T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Butanol Increases Channel Gating Probability in Human 5-HT3A Receptors
author list: Ruesch D, Mittelstein M, Wulf H, Raines DE
published in: Anesthesiology
information resource reference: Butanol Increases Channel Gating Probability in Human 5-HT3A Receptors. Anesthesiology. 2006; A174.
publication date: 2006-10-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

The Molecular Basis of NMDA Receptor Inhibition by Aromatic Volatile General Anesthetics
author list: Sewell JC, Sear JW, Raines DE, Eger EI, Laster MJ
published in: Anesthesiology
information resource reference: The Molecular Basis of NMDA Receptor Inhibition by Aromatic Volatile General Anesthetics. Anesthesiology. 2006; A776.
publication date: 2006-10-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Isoflurane increases the apparent agonist affinity of the nicotinic acetylcholine receptor by reducing the microscopic agonist dissociation constant.
PubMed Identifier: 10719956
author list: Raines DE, Zachariah VT
published in: Anesthesiology
information resource reference: Isoflurane increases the apparent agonist affinity of the nicotinic acetylcholine receptor by reducing the microscopic agonist dissociation constant. Anesthesiology. 2000 Mar; 92(3):775-85.
journal title abbreviation: Anesthesiology
publication date: 2000-03-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 110009
type: Authorship
author rank in publication: 8
linked author: Raines, Douglas
linked information resource: Increases in spinal cerebrospinal fluid potassium concentration do not increase isoflurane minimum alveolar concentration in rats.

Kinetics of anesthetic-induced conformational transitions in a four-alpha-helix bundle protein.
PubMed Identifier: 16445285
author list: Solt K, Johansson JS, Raines DE
published in: Biochemistry
information resource reference: Kinetics of anesthetic-induced conformational transitions in a four-alpha-helix bundle protein. Biochemistry. 2006 Feb 07; 45(5):1435-41.
journal title abbreviation: Biochemistry
publication date: 2006-02-07T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

General anesthetics increase the apparent agonist affinity of the nicotinic acetylcholine receptor: a case of (super)family resemblance
author list: Raines DE, Zachariah ZT
published in: Anesthesiology
information resource reference: General anesthetics increase the apparent agonist affinity of the nicotinic acetylcholine receptor: a case of (super)family resemblance. Anesthesiology. 1999.
publication date: 1999-01-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Kinetic modeling of isoflurane’s effect on nicotinic acetylcholine receptor desensitization implicates a reduction in the agonist dissociation constant
author list: Raines DE, Zachariah ZT
published in: Anesthesiology
information resource reference: Kinetic modeling of isoflurane’s effect on nicotinic acetylcholine receptor desensitization implicates a reduction in the agonist dissociation constant. Anesthesiology. 1999.
publication date: 1999-01-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Intra-anesthetic Problems
author list: Baker K, Raines DE
published in: Clinical Anesthesia Procedures of the Massachusetts General Hospital
information resource reference: Intra-anesthetic Problems. Clinical Anesthesia Procedures of the Massachusetts General Hospital. 1998; 287-312.
publication date: 1998-01-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Selective Receptor Actions of Nonhalogenated Alkane Anesthetics
author list: Raines DE, Scheller M, Forman SA, Claycomb RJ
published in: Molecular and Basic Mechanisms of Anesthesia
information resource reference: Selective Receptor Actions of Nonhalogenated Alkane Anesthetics. Molecular and Basic Mechanisms of Anesthesia. 2002.
publication date: 2002-01-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Hexafluorobenzene Acts in the Spinal Cord, While 0-diflurobenzene Can Act in Either Brain or Spinal Cord, to Produce Immobility
author list: Antognini JF, Raines DE, Solt K, Barter L, Atherley R, Laster M, Eger E
published in: Society for Neuroscience Meeting
information resource reference: Hexafluorobenzene Acts in the Spinal Cord, While 0-diflurobenzene Can Act in Either Brain or Spinal Cord, to Produce Immobility. Society for Neuroscience Meeting. 2006; A174.
publication date: 2006-10-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

On the importance of volatile agents devoid of anesthetic action.
PubMed Identifier: 7677814
author list: Raines DE, Miller KW
published in: Anesthesia and analgesia
information resource reference: On the importance of volatile agents devoid of anesthetic action. Anesth Analg. 1994 Dec; 79(6):1031-3.
journal title abbreviation: Anesth Analg
publication date: 1994-12-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 113787
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: Conformational transitions of the nicotinic acetylcholine receptor as a model for anesthetic actions on ligand-gated ion channels: single and sequential mixing stopped-flow fluorescence studies.

Etomidate
MeSH DescriptorUI: D005045
MeSH semantic group name: Chemicals & Drugs
number of authors: 50
number of publications: 194
uniqueness weight: 0.825963
type: Concept

Adrenal Cortex
MeSH DescriptorUI: D000302
MeSH semantic group name: Anatomy
number of authors: 85
number of publications: 148
uniqueness weight: 0.906142
type: Concept

Hypnotics and Sedatives
MeSH DescriptorUI: D006993
MeSH semantic group name: Chemicals & Drugs
number of authors: 583
number of publications: 1208
uniqueness weight: 0.549879
type: Concept

Anesthetics, Intravenous
MeSH DescriptorUI: D018686
MeSH semantic group name: Chemicals & Drugs
number of authors: 225
number of publications: 395
uniqueness weight: 0.783504
type: Concept

Receptors, GABA-A
MeSH DescriptorUI: D011963
MeSH semantic group name: Chemicals & Drugs
number of authors: 217
number of publications: 648
uniqueness weight: 0.712661
type: Concept

Anaesthesia
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Emeritus
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Medicine
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Pulmonary
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Brigham and Women's Hospital
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Harvard Medical School
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Massachusetts General Hospital
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Miller, Keith
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Person ID: 74878
person in primary position: Mallinckrodt Professor of Pharmacology in the Department of Anaesthesia
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Wittenberg, Jack
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person in primary position: Professor of Radiology, Emeritus
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Vacanti, Joseph
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person in primary position: John Homans Professor of Surgery, Emeritus
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Forman, Stuart
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person in primary position: Professor of Anaesthesia
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Novelline, Robert
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latitude: 42.36241700000000
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person in primary position: Professor of Radiology, Emeritus
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Cotten, Joseph
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first name: Joseph
last name: Cotten
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has faculty rank: Associate Professor
latitude: 42.36241700000000
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Person ID: 58961
person in primary position: Associate Professor of Anaesthesia
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Picard, Michael
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first name: Michael
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latitude: 42.36241700000000
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Person ID: 40182
person in primary position: Professor of Medicine, Emeritus
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Authorship 1159001
type: Authorship
author rank in publication: 6
linked author: Raines, Douglas
linked information resource: Toxicologic and Inhibitory Receptor Actions of the Etomidate Analog ABP-700 and Its Metabolite CPM-Acid.

Toxicologic and Inhibitory Receptor Actions of the Etomidate Analog ABP-700 and Its Metabolite CPM-Acid.
PubMed Identifier: 31166238
author list: Valk BI, McGrath M, Lehoux D, Zerler B, Marota JJA, Raines DE
published in: Anesthesiology
information resource reference: Toxicologic and Inhibitory Receptor Actions of the Etomidate Analog ABP-700 and Its Metabolite CPM-Acid. Anesthesiology. 2019 08; 131(2):287-304.
journal title abbreviation: Anesthesiology
publication date: 2019-08-01T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Solt, Ken
eCommons Login: KS52
first name: Ken
last name: Solt
full name: Ken Solt, M.D.
has faculty rank: Full Professor
latitude: 42.36241700000000
longitude: -71.06893700000000
photo: https://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 58973
person in primary position: Edward Mallinckrodt Jr. Professor of Anaesthesia in the Field of Pharmacology and Innovation
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preferred title: Edward Mallinckrodt Jr. Professor of Anaesthesia in the Field of Pharmacology and Innovation

Authorship 131392
type: Authorship
author rank in publication: 2
linked author: Raines, Douglas
linked information resource: Hexafluorobenzene acts in the spinal cord, whereas o-difluorobenzene acts in both brain and spinal cord, to produce immobility.

Brown, Emery
eCommons Login: ENB1
first name: Emery
last name: Brown
full name: Emery Neal Brown, M.D., Ph.D.
has faculty rank: Full Professor
latitude: 42.36241700000000
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Person ID: 56965
person in primary position: Warren M. Zapol Professor of Anaesthesia
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Rubash, Harry
eCommons Login: HER1
first name: Harry
last name: Rubash
full name: Harry E. Rubash, M.D.
has faculty rank: Full Professor
latitude: 42.36241700000000
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person in primary position: Edith M. Ashley Professor of Orthopedic Surgery, Emeritus
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Cohen, Jonathan
eCommons Login: JBC2
first name: Jonathan
last name: Cohen
full name: Jonathan B. Cohen, Ph.D.
has faculty rank: Full Professor
latitude: 42.33594500000000
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Person ID: 14275
person in primary position: Bullard Professor of Neurobiology, Emeritus
type: Agent
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Authorship 136255
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: The role of charge in lipid selectivity for the nicotinic acetylcholine receptor.

Authorship 1179875
type: Authorship
author rank in publication: 3
linked author: Raines, Douglas
linked information resource: Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats.

Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats.
PubMed Identifier: 31383012
author list: McGrath M, Hofmann A, Raines DE
published in: BMC pharmacology & toxicology
information resource reference: Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats. BMC Pharmacol Toxicol. 2019 08 05; 20(1):48.
journal title abbreviation: BMC Pharmacol Toxicol
publication date: 2019-08-05T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 135911
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author rank in publication: 6
linked author: Raines, Douglas
linked information resource: Electroencephalographic recovery, hypnotic emergence, and the effects of metabolite after continuous infusions of a rapidly metabolized etomidate analog in rats.

Authorship 1196437
type: Authorship
author rank in publication: 3
linked author: Raines, Douglas
linked information resource: Computational Approaches to Anesthetic Drug Discovery.

Computational Approaches to Anesthetic Drug Discovery.
PubMed Identifier: 31623940
author list: McGrath M, Pence A, Raines DE
published in: Trends in pharmacological sciences
information resource reference: Computational Approaches to Anesthetic Drug Discovery. Trends Pharmacol Sci. 2019 11; 40(11):809-811.
journal title abbreviation: Trends Pharmacol Sci
publication date: 2019-10-14T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 124887
type: Authorship
author rank in publication: 7
linked author: Raines, Douglas
linked information resource: Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression.

Authorship 1223057
type: Authorship
author rank in publication: 3
linked author: Raines, Douglas
linked information resource: The effects of a competitive antagonist on GABA-evoked currents in the presence of sedative-hypnotic agents.

The effects of a competitive antagonist on GABA-evoked currents in the presence of sedative-hypnotic agents.
PubMed Identifier: 32016849
author list: McGrath M, Tolia M, Raines DE
published in: Pharmacological reports : PR
information resource reference: The effects of a competitive antagonist on GABA-evoked currents in the presence of sedative-hypnotic agents. Pharmacol Rep. 2020 Feb; 72(1):260-266.
journal title abbreviation: Pharmacol Rep
publication date: 2020-01-08T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1257394
type: Authorship
author rank in publication: 9
linked author: Raines, Douglas
linked information resource: Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABAA Receptor and In Vivo Zebrafish Studies.

Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABAA Receptor and In Vivo Zebrafish Studies.
PubMed Identifier: 32541553
author list: McGrath M, Hoyt H, Pence A, Jayakar SS, Zhou X, Forman SA, Cohen JB, Miller KW, Raines DE
published in: Anesthesiology
information resource reference: Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABAA Receptor and In Vivo Zebrafish Studies. Anesthesiology. 2020 09; 133(3):583-594.
journal title abbreviation: Anesthesiology
publication date: 2020-09-01T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 213920
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: Transient low-affinity agonist binding to Torpedo postsynaptic membranes resolved by using sequential mixing stopped-flow fluorescence spectroscopy.

Authorship 157451
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: Modulation of GABA(A) receptor function by nonhalogenated alkane anesthetics: the effects on agonist enhancement, direct activation, and inhibition.

Lecturer on Medicine, Part-time
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position in department: Medicine
position in division: Pulmonary
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HR job title: Lecturer on Medicine, Part-time
position in organization: Brigham and Women's Hospital

Devlin, John
eCommons Login: jod3241
first name: John
last name: Devlin
full name: John W. Devlin, Pharm.D.
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Authorship 1314274
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author rank in publication: 9
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linked information resource: Competitive Antagonism of Etomidate Action by Diazepam.

Competitive Antagonism of Etomidate Action by Diazepam.
PubMed Identifier: 33370831
author list: McGrath M, Hoyt H, Pence A, Jayakar SS, Zhou X, Forman SA, Cohen JB, Miller KW, Raines DE
published in: Anesthesiology
information resource reference: Competitive Antagonism of Etomidate Action by Diazepam. Anesthesiology. 2020 09 01; 133(3):583-594.
journal title abbreviation: Anesthesiology
publication date: 2020-09-01T00:00:00
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Authorship 1329008
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linked information resource: Etomidate and Adrenocortical Suppression: Should We Take the Concerns to Heart?

Etomidate and Adrenocortical Suppression: Should We Take the Concerns to Heart?
PubMed Identifier: 33579572
author list: Dalia AA, Raines DE
published in: Journal of cardiothoracic and vascular anesthesia
information resource reference: Etomidate and Adrenocortical Suppression: Should We Take the Concerns to Heart? J Cardiothorac Vasc Anesth. 2021 04; 35(4):1086-1088.
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Authorship 211186
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author rank in publication: 3
linked author: Raines, Douglas
linked information resource: Differential modulation of human N-methyl-D-aspartate receptors by structurally diverse general anesthetics.

Authorship 1384464
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author rank in publication: 5
linked author: Raines, Douglas
linked information resource: Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABAA receptor: In vitro and in vivo studies.

Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABAA receptor: In vitro and in vivo studies.
PubMed Identifier: 34386973
author list: McGrath M, Hoyt H, Pence A, Forman SA, Raines DE
published in: British journal of pharmacology
information resource reference: Selective actions of benzodiazepines at the transmembrane anaesthetic binding sites of the GABAA receptor: In vitro and in vivo studies. Br J Pharmacol. 2021 12; 178(24):4842-4858.
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Authorship 1435744
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linked author: Raines, Douglas
linked information resource: Pharmacological management of severe Cushing's syndrome: the role of etomidate.

Pharmacological management of severe Cushing's syndrome: the role of etomidate.
PubMed Identifier: 35186251
author list: Pence A, McGrath M, Lee SL, Raines DE
published in: Therapeutic advances in endocrinology and metabolism
information resource reference: Pharmacological management of severe Cushing's syndrome: the role of etomidate. Ther Adv Endocrinol Metab. 2022; 13:20420188211058583.
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Authorship 1499768
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linked information resource: Competitive Interactions Between Propofol and Diazepam: Studies in GABAA Receptors and Zebrafish.

Competitive Interactions Between Propofol and Diazepam: Studies in GABAA Receptors and Zebrafish.
PubMed Identifier: 36167415
author list: Pence A, Hoyt H, McGrath M, Forman SA, Raines DE
published in: The Journal of pharmacology and experimental therapeutics
information resource reference: Competitive Interactions Between Propofol and Diazepam: Studies in GABAA Receptors and Zebrafish. J Pharmacol Exp Ther. 2022 12; 383(3):238-245.
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Bullard Professor of Neurobiology, Emeritus
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HR job title: Bullard Professor of Neurobiology, Emeritus
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Authorship 583630
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linked information resource: Electron Spin Resonance (ESR) studies into the origin of selectivity for negatively charged lipids at the lipid-protein interface of the nicotinic acetylcholine receptor

Authorship 216310
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author rank in publication: 1
linked author: Raines, Douglas
linked information resource: Nonhalogenated anesthetic alkanes and perhalogenated nonimmobilizing alkanes inhibit alpha(4)beta(2) neuronal nicotinic acetylcholine receptors.

Edward Mallinckrodt, Jr. Professor of Anaesthesia in the Field Pharmacology and Innovation, Emeritus
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HR job title: Edward Mallinckrodt, Jr. Professor of Anaesthesia in the Field Pharmacology and Innovation, Emeritus
position in organization: Harvard Medical School

Authorship 599559
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linked information resource: MOC-etomidate: A Novel, Rapidly Metabolized and Ultra-Short-Acting Etomidate Analogue

Authorship 319119
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author rank in publication: 6
linked author: Raines, Douglas
linked information resource: Automated documentation error detection and notification improves anesthesia billing performance.

Authorship 436972
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author rank in publication: 2
linked author: Raines, Douglas
linked information resource: A comparison of the molecular bases for N-methyl-D-aspartate-receptor inhibition versus immobilizing activities of volatile aromatic anesthetics.

Authorship 596044
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linked author: Raines, Douglas
linked information resource: General anesthetics increase the apparent agonist affinity of the nicotinic acetylcholine receptor: a case of (super)family resemblance

Authorship 647287
type: Authorship
author rank in publication: 8
linked author: Raines, Douglas
linked information resource: Carboetomidate: an analog of etomidate that interacts weakly with 11ß-hydroxylase.

Authorship 649584
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author rank in publication: 3
linked author: Raines, Douglas
linked information resource: Anesthetic drug development: Novel drugs and new approaches.

Anesthetic drug development: Novel drugs and new approaches.
PubMed Identifier: 23653886
author list: Chitilian HV, Eckenhoff RG, Raines DE
published in: Surgical neurology international
information resource reference: Anesthetic drug development: Novel drugs and new approaches. Surg Neurol Int. 2013; 4(Suppl 1):S2-S10.
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Carboetomidate: an analog of etomidate that interacts weakly with 11ß-hydroxylase.
PubMed Identifier: 23492967
author list: Shanmugasundararaj S, Zhou X, Neunzig J, Bernhardt R, Cotten JF, Ge R, Miller KW, Raines DE
published in: Anesthesia and analgesia
information resource reference: Carboetomidate: an analog of etomidate that interacts weakly with 11ß-hydroxylase. Anesth Analg. 2013 Jun; 116(6):1249-56.
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publication date: 2013-03-14T00:00:00
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Authorship 628494
type: Authorship
linked author: Raines, Douglas
linked information resource: Anesthetic Action on the Nicotinic Acetylcholine Receptor

Authorship 568483
type: Authorship
author rank in publication: 5
linked author: Raines, Douglas
linked information resource: Electroencephalographic and hypnotic recoveries after brief and prolonged infusions of etomidate and optimized soft etomidate analogs.

Authorship 596717
type: Authorship
linked author: Raines, Douglas
linked information resource: NMDA receptor inhibitory potencies of volatile aromatic anesthetics: the role of cation-pi interactions

Authorship 316108
type: Authorship
author rank in publication: 10
linked author: Raines, Douglas
linked information resource: p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels.

Edith M. Ashley Professor of Orthopedic Surgery, Emeritus
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position in department: Emeritus
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HR job title: Edith M. Ashley Professor of Orthopedic Surgery, Emeritus
position in organization: Harvard Medical School

Professor of Radiology, Emeritus
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HR job title: Professor of Radiology, Emeritus
position in organization: Harvard Medical School

Professor of Radiology, Emeritus
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HR job title: Professor of Radiology, Emeritus
position in organization: Harvard Medical School

Authorship 207538
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: General anesthetics modify the kinetics of nicotinic acetylcholine receptor desensitization at clinically relevant concentrations.

Authorship 240916
type: Authorship
author rank in publication: 4
linked author: Raines, Douglas
linked information resource: Inhibition of human alpha4beta2 neuronal nicotinic acetylcholine receptors by volatile aromatic anesthetics depends on drug hydrophobicity.

Authorship 611537
type: Authorship
linked author: Raines, Douglas
linked information resource: Improving billing effectiveness with automated anesthesia information management

Authorship 26206
type: Authorship
author rank in publication: 4
linked author: Raines, Douglas
linked information resource: Modifying methoxycarbonyl etomidate inter-ester spacer optimizes in vitro metabolic stability and in vivo hypnotic potency and duration of action.

John Homans Professor of Surgery, Emeritus
is primary position: true
position in department: Emeritus
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
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HR job title: John Homans Professor of Surgery, Emeritus
position in organization: Harvard Medical School

Authorship 313743
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: On the importance of volatile agents devoid of anesthetic action.

Authorship 474370
type: Authorship
author rank in publication: 3
linked author: Raines, Douglas
linked information resource: Aprotinin administration and pulmonary thromboembolism during orthotopic liver transplantation: report of two cases.

Authorship 721080
type: Authorship
author rank in publication: 6
linked author: Raines, Douglas
linked information resource: The pharmacology of cyclopropyl-methoxycarbonyl metomidate: a comparison with propofol.

The pharmacology of cyclopropyl-methoxycarbonyl metomidate: a comparison with propofol.
PubMed Identifier: 24557104
author list: Ge R, Pejo E, Gallin H, Jeffrey S, Cotten JF, Raines DE
published in: Anesthesia and analgesia
information resource reference: The pharmacology of cyclopropyl-methoxycarbonyl metomidate: a comparison with propofol. Anesth Analg. 2014 Mar; 118(3):563-7.
journal title abbreviation: Anesth Analg
publication date: 2014-03-01T00:00:00
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type: Academic Article
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Authorship 166798
type: Authorship
author rank in publication: 3
linked author: Raines, Douglas
linked information resource: Time-dependent binding of paramagnetic and fluorescent hydrophobic ions to the acetylcholine receptor from Torpedo.

Professor of Medicine, Emeritus
is primary position: true
position in department: Emeritus
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Medicine, Emeritus
position in organization: Harvard Medical School

Authorship 196903
type: Authorship
author rank in publication: 4
linked author: Raines, Douglas
linked information resource: Molecular properties important for inhaled anesthetic action on human 5-HT3A receptors.

Warren M. Zapol Professor of Anaesthesia
is primary position: true
position in department: Anaesthesia
position in division: Research
sort order: 1
type: Position
HR job title: Warren M. Zapol Professor of Anaesthesia
position in organization: Massachusetts General Hospital

Professor of Anaesthesia
is primary position: true
position in department: Anaesthesia
position in division: Multispecialty
sort order: 1
type: Position
HR job title: Professor of Anaesthesia
position in organization: Massachusetts General Hospital

Mallinckrodt Professor of Pharmacology in the Department of Anaesthesia
is primary position: true
position in department: Anaesthesia
position in division: Research
sort order: 1
type: Position
HR job title: Mallinckrodt Professor of Pharmacology in the Department of Anaesthesia
position in organization: Massachusetts General Hospital

Associate Professor of Anaesthesia
is primary position: true
position in department: Anaesthesia
position in division: Neuro
sort order: 1
type: Position
HR job title: Associate Professor of Anaesthesia
position in organization: Massachusetts General Hospital

Multispecialty
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type: Organization

Neuro
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type: Organization

Obstetric
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type: Organization

Research
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type: Organization

Authorship 3778
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: Electron spin resonance studies of acyl chain motion in reconstituted nicotinic acetylcholine receptor membranes.

Edward Mallinckrodt Jr. Professor of Anaesthesia in the Field of Pharmacology and Innovation
is primary position: true
position in department: Anaesthesia
position in division: Obstetric
sort order: 1
type: Position
HR job title: Edward Mallinckrodt Jr. Professor of Anaesthesia in the Field of Pharmacology and Innovation
position in organization: Massachusetts General Hospital

Authorship 280904
type: Authorship
author rank in publication: 4
linked author: Raines, Douglas
linked information resource: Acetylcholine receptors and thresholds for convulsions from flurothyl and 1,2-dichlorohexafluorocyclobutane.

Authorship 296030
type: Authorship
author rank in publication: 2
linked author: Raines, Douglas
linked information resource: Development of a novel probe for measuring drug binding to the F1*S variant of human alpha 1-acid glycoprotein.

Authorship 746802
type: Authorship
author rank in publication: 4
linked author: Raines, Douglas
linked information resource: Adrenocortical suppression and recovery after continuous hypnotic infusion: etomidate versus its soft analogue cyclopropyl-methoxycarbonyl metomidate.

Authorship 752084
type: Authorship
author rank in publication: 6
linked author: Raines, Douglas
linked information resource: Analogues of etomidate: modifications around etomidate's chiral carbon and the impact on in vitro and in vivo pharmacology.

Analogues of etomidate: modifications around etomidate's chiral carbon and the impact on in vitro and in vivo pharmacology.
PubMed Identifier: 24777068
author list: Pejo E, Santer P, Jeffrey S, Gallin H, Husain SS, Raines DE
published in: Anesthesiology
information resource reference: Analogues of etomidate: modifications around etomidate's chiral carbon and the impact on in vitro and in vivo pharmacology. Anesthesiology. 2014 Aug; 121(2):290-301.
journal title abbreviation: Anesthesiology
publication date: 2014-08-01T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Adrenocortical suppression and recovery after continuous hypnotic infusion: etomidate versus its soft analogue cyclopropyl-methoxycarbonyl metomidate.
PubMed Identifier: 23363638
author list: Ge R, Pejo E, Cotten JF, Raines DE
published in: Critical care (London, England)
information resource reference: Adrenocortical suppression and recovery after continuous hypnotic infusion: etomidate versus its soft analogue cyclopropyl-methoxycarbonyl metomidate. Crit Care. 2013 Jan 30; 17(1):R20.
journal title abbreviation: Crit Care
publication date: 2013-01-30T00:00:00
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type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 580448
type: Authorship
linked author: Raines, Douglas
linked information resource: Lipid disordering predicts anesthetic cutoff in cycloalkanemethanols

Authorship 585455
type: Authorship
linked author: Raines, Douglas
linked information resource: The Variable Effects of Volatile Aromatic Anesthetics on GABA A Receptor Function

Authorship 597689
type: Authorship
linked author: Raines, Douglas
linked information resource: The kinetics of halothane interactions with nicotinic acetylcholine receptor membranes: stopped-flow studies of intrinsic fluorescence quenching

Authorship 612033
type: Authorship
linked author: Raines, Douglas
linked information resource: Effects of Etomidate and Photoactivatable Etomidate Analogues on Adrenal Cortisol Synthesis

Authorship 212778
type: Authorship
author rank in publication: 3
linked author: Raines, Douglas
linked information resource: The pyrrole etomidate analog carboetomidate potently inhibits human 5-HT3A receptor function: comparisons with etomidate and potential implications for emetogenesis.

Authorship 625559
type: Authorship
linked author: Raines, Douglas
linked information resource: Contrasting effects of NMDA receptor inhibition by MK-801 on the immobilizing potencies of aromatic and non-aromatic inhaled anesthetics

Authorship 770323
type: Authorship
author rank in publication: 5
linked author: Raines, Douglas
linked information resource: Advancing novel anesthetics: pharmacodynamic and pharmacokinetic studies of cyclopropyl-methoxycarbonyl metomidate in dogs.

Advancing novel anesthetics: pharmacodynamic and pharmacokinetic studies of cyclopropyl-methoxycarbonyl metomidate in dogs.
PubMed Identifier: 25170571
author list: Campagna JA, Pojasek K, Grayzel D, Randle J, Raines DE
published in: Anesthesiology
information resource reference: Advancing novel anesthetics: pharmacodynamic and pharmacokinetic studies of cyclopropyl-methoxycarbonyl metomidate in dogs. Anesthesiology. 2014 Dec; 121(6):1203-16.
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publication date: 2014-12-01T00:00:00
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type: Academic Article
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Authorship 544284
type: Authorship
author rank in publication: 7
linked author: Raines, Douglas
linked information resource: Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.

Authorship 546637
type: Authorship
author rank in publication: 9
linked author: Raines, Douglas
linked information resource: In vivo and in vitro pharmacological studies of methoxycarbonyl-carboetomidate.

Authorship 579841
type: Authorship
linked author: Raines, Douglas
linked information resource: Butanol Increases Channel Gating Probability in Human 5-HT3A Receptors

Authorship 595355
type: Authorship
linked author: Raines, Douglas
linked information resource: Functional Aspects of Acetylcholine Receptor-Lipid Interactions

Authorship 611280
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linked author: Raines, Douglas
linked information resource: Cholesterol modulates anesthetic sensitivity in reconstituted nicotinic acetylcholine receptors

Authorship 620958
type: Authorship
linked author: Raines, Douglas
linked information resource: Inhibition of Human 5-HT3A and 5-HT3AB Receptors by Etomidate, Propofol and Pentobarbital

Authorship 381090
type: Authorship
author rank in publication: 9
linked author: Raines, Douglas
linked information resource: Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels.

Authorship 410194
type: Authorship
author rank in publication: 2
linked author: Raines, Douglas
linked information resource: Is a new paradigm needed to explain how inhaled anesthetics produce immobility?

Authorship 424190
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: Isoflurane increases the apparent agonist affinity of the nicotinic acetylcholine receptor.

Authorship 470614
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: The enhancement of proton/hydroxyl flow across lipid vesicles by inhalation anesthetics.

Authorship 453610
type: Authorship
author rank in publication: 2
linked author: Raines, Douglas
linked information resource: Lipid-protein interactions and protein dynamics in vesicles containing the nicotinic acetylcholine receptor: a study with ethanol.

Authorship 460035
type: Authorship
author rank in publication: 11
linked author: Raines, Douglas
linked information resource: Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function.

Authorship 463866
type: Authorship
author rank in publication: 7
linked author: Raines, Douglas
linked information resource: Closed-loop continuous infusions of etomidate and etomidate analogs in rats: a comparative study of dosing and the impact on adrenocortical function.

Authorship 596461
type: Authorship
linked author: Raines, Douglas
linked information resource: Introduction of the 5-HT3B subunit decreases the sensitivity of 5-HT3A receptors to the potentiating actions of general anesthetics

Authorship 607540
type: Authorship
linked author: Raines, Douglas
linked information resource: Kinetic modeling of isoflurane’s effect on nicotinic acetylcholine receptor desensitization implicates a reduction in the agonist dissociation constant

Authorship 610692
type: Authorship
linked author: Raines, Douglas
linked information resource: Neural Mechanisms of Anesthesia

Authorship 513954
type: Authorship
author rank in publication: 4
linked author: Raines, Douglas
linked information resource: General anesthetic-induced channel gating enhancement of 5-hydroxytryptamine type 3 receptors depends on receptor subunit composition.

Authorship 5163
type: Authorship
author rank in publication: 5
linked author: Raines, Douglas
linked information resource: Differential effects of serotonin and dopamine on human 5-HT3A receptor kinetics: interpretation within an allosteric kinetic model.

Authorship 59995
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: Perturbation of lipid and protein structure by general anesthetics: how little is too little?

Authorship 591121
type: Authorship
linked author: Raines, Douglas
linked information resource: Intra-anesthetic Problems

Authorship 596846
type: Authorship
linked author: Raines, Douglas
linked information resource: The Future of Anesthetic Mechanisms Research

Authorship 72676
type: Authorship
author rank in publication: 6
linked author: Raines, Douglas
linked information resource: Contrasting roles of the N-methyl-D-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics.

Authorship 198554
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: The role of electrostatic interactions in governing anesthetic action on the torpedo nicotinic acetylcholine receptor.

Authorship 387580
type: Authorship
author rank in publication: 5
linked author: Raines, Douglas
linked information resource: Subunit-dependent modulation of the 5-hydroxytryptamine type 3 receptor open-close equilibrium by n-alcohols.

Authorship 27627
type: Authorship
author rank in publication: 3
linked author: Raines, Douglas
linked information resource: Carboetomidate inhibits alpha4/beta2 neuronal nicotinic acetylcholine receptors at concentrations affecting animals.

Authorship 352879
type: Authorship
author rank in publication: 3
linked author: Raines, Douglas
linked information resource: Kinetics of anesthetic-induced conformational transitions in a four-alpha-helix bundle protein.

Authorship 547974
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: Potential-dependent phase partitioning of fluorescent hydrophobic ions in phospholipid vesicles.

Authorship 591127
type: Authorship
linked author: Raines, Douglas
linked information resource: Anesthesia for Liver Surgery and Transplantation

Authorship 599675
type: Authorship
linked author: Raines, Douglas
linked information resource: Plus Ca Change

Authorship 601139
type: Authorship
linked author: Raines, Douglas
linked information resource: The 5-HT3B subunit influences 5-HT3 receptor kinetics and pharmacology

Authorship 622174
type: Authorship
linked author: Raines, Douglas
linked information resource: Co-expression of the 5-HT3B subunit attenuates general anesthetic action on 5-HT3 receptor channel gating efficacy

Authorship 628264
type: Authorship
linked author: Raines, Douglas
linked information resource: Volatile anesthetics reduce the agonist EC50 of the human 5-HT3A receptor by increasing channel gating probability

Authorship 385909
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: Isoflurane increases the apparent agonist affinity of the nicotinic acetylcholine receptor by reducing the microscopic agonist dissociation constant.

Authorship 261916
type: Authorship
author rank in publication: 5
linked author: Raines, Douglas
linked information resource: Azo-propofols: photochromic potentiators of GABA(A) receptors.

Authorship 277726
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: Halothane interactions with nicotinic acetylcholine receptor membranes. Steady-state and kinetic studies of intrinsic fluorescence quenching.

Cyclopropyl-methoxycarbonyl Metomidate: Studies in a Lipopolysaccharide Inflammatory Model of Sepsis.
PubMed Identifier: 26035348
author list: Santer P, Pejo E, Feng Y, Chao W, Raines DE
published in: Anesthesiology
information resource reference: Cyclopropyl-methoxycarbonyl Metomidate: Studies in a Lipopolysaccharide Inflammatory Model of Sepsis. Anesthesiology. 2015 Aug; 123(2):368-76.
journal title abbreviation: Anesthesiology
publication date: 2015-08-01T00:00:00
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type: Academic Article
type: Article
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Authorship 557812
type: Authorship
author rank in publication: 10
linked author: Raines, Douglas
linked information resource: Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration.

Authorship 159867
type: Authorship
author rank in publication: 6
linked author: Raines, Douglas
linked information resource: Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia.

Authorship 475888
type: Authorship
author rank in publication: 5
linked author: Raines, Douglas
linked information resource: Inhibition of human 5-HT(3A) and 5-HT(3AB) receptors by etomidate, propofol and pentobarbital.

Authorship 802638
type: Authorship
author rank in publication: 2
linked author: Raines, Douglas
linked information resource: Total Intravenous Anesthesia Using N-Methyl-D-Aspartate (NMDA) Receptor-Sparing Drugs in a Patient with Anti-NMDA Receptor Encephalitis.

Authorship 805164
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: The pharmacology of etomidate and etomidate derivatives.

Total Intravenous Anesthesia Using N-Methyl-D-Aspartate (NMDA) Receptor-Sparing Drugs in a Patient with Anti-NMDA Receptor Encephalitis.
PubMed Identifier: 25611647
author list: Broderick DK, Raines DE, Nanji KC
published in: A & A case reports
information resource reference: Total Intravenous Anesthesia Using N-Methyl-D-Aspartate (NMDA) Receptor-Sparing Drugs in a Patient with Anti-NMDA Receptor Encephalitis. A A Case Rep. 2014 Apr 01; 2(7):83-5.
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publication date: 2014-04-01T00:00:00
year: 2014
type: Academic Article
type: Article
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The pharmacology of etomidate and etomidate derivatives.
PubMed Identifier: 25807019
author list: Raines DE
published in: International anesthesiology clinics
information resource reference: The pharmacology of etomidate and etomidate derivatives. Int Anesthesiol Clin. 2015; 53(2):63-75.
journal title abbreviation: Int Anesthesiol Clin
publication date: 2015-01-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 620912
type: Authorship
linked author: Raines, Douglas
linked information resource: Hexafluorobenzene Acts in the Spinal Cord, While 0-diflurobenzene Can Act in Either Brain or Spinal Cord, to Produce Immobility

Authorship 625157
type: Authorship
linked author: Raines, Douglas
linked information resource: Lipids modulate ethanol-induced desensitization of nicotinic acetylcholine receptors

Authorship 77191
type: Authorship
author rank in publication: 2
linked author: Raines, Douglas
linked information resource: Nonanesthetic volatile drugs obey the Meyer-Overton correlation in two molecular protein site models.

Authorship 282269
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: Anesthetic cutoff in cycloalkanemethanols. A test of current theories.

Authorship 34549
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: The alkyl chain dependence of the effect of normal alcohols on agonist-induced nicotinic acetylcholine receptor desensitization kinetics.

Authorship 398356
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: Artifactual hypertension due to transducer cable malfunction.

Authorship 420302
type: Authorship
author rank in publication: 2
linked author: Raines, Douglas
linked information resource: A hydrophobic inhibitor of the nicotinic acetylcholine receptor acts on the resting state.

Authorship 484087
type: Authorship
author rank in publication: 6
linked author: Raines, Douglas
linked information resource: Pharmacological studies of methoxycarbonyl etomidate's carboxylic acid metabolite.

Authorship 500127
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: Anesthetic management and outcome following noncardiac surgery in nonparturients with Eisenmenger's physiology.

Authorship 339863
type: Authorship
author rank in publication: 8
linked author: Raines, Douglas
linked information resource: Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats.

Authorship 816835
type: Authorship
author rank in publication: 5
linked author: Raines, Douglas
linked information resource: Cyclopropyl-methoxycarbonyl Metomidate: Studies in a Lipopolysaccharide Inflammatory Model of Sepsis.

Authorship 370706
type: Authorship
author rank in publication: 6
linked author: Raines, Douglas
linked information resource: p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol.

Authorship 615914
type: Authorship
linked author: Raines, Douglas
linked information resource: Intra-anesthetic Problems

Authorship 848595
type: Authorship
author rank in publication: 8
linked author: Raines, Douglas
linked information resource: Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the a1 ß3 ?2L GABAA receptor account for their in vivo effects.

Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the a1 ß3 ?2L GABAA receptor account for their in vivo effects.
PubMed Identifier: 26378885
author list: Desai R, Savechenkov PY, Zolkowska D, Ge RL, Rogawski MA, Bruzik KS, Forman SA, Raines DE, Miller KW
published in: The Journal of physiology
information resource reference: Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the a1 ß3 ?2L GABAA receptor account for their in vivo effects. J Physiol. 2015 Nov 15; 593(22):4943-61.
journal title abbreviation: J Physiol
publication date: 2015-11-15T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 616815
type: Authorship
linked author: Raines, Douglas
linked information resource: Molecular mechanisms of general anesthesia. in the Harvard Electronic Anesthesia Library. Bailin M, Bergeron B, Dershwitz M. eds

Authorship 863467
type: Authorship
author rank in publication: 6
linked author: Raines, Douglas
linked information resource: ?-Aminobutyric Acid Type A Receptor Modulation by Etomidate Analogs.

?-Aminobutyric Acid Type A Receptor Modulation by Etomidate Analogs.
PubMed Identifier: 26691905
author list: Pejo E, Santer P, Wang L, Dershwitz P, Husain SS, Raines DE
published in: Anesthesiology
information resource reference: ?-Aminobutyric Acid Type A Receptor Modulation by Etomidate Analogs. Anesthesiology. 2016 Mar; 124(3):651-63.
journal title abbreviation: Anesthesiology
publication date: 2016-03-01T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 616212
type: Authorship
linked author: Raines, Douglas
linked information resource: Management of the parturient with hepatic disease

Authorship 873043
type: Authorship
author rank in publication: 4
linked author: Raines, Douglas
linked information resource: Distinct Hypnotic Recoveries After Infusions of Methoxycarbonyl Etomidate and Cyclopropyl Methoxycarbonyl Metomidate: The Role of the Metabolite.

Distinct Hypnotic Recoveries After Infusions of Methoxycarbonyl Etomidate and Cyclopropyl Methoxycarbonyl Metomidate: The Role of the Metabolite.
PubMed Identifier: 26991617
author list: Pejo E, Liu J, Lin X, Raines DE
published in: Anesthesia and analgesia
information resource reference: Distinct Hypnotic Recoveries After Infusions of Methoxycarbonyl Etomidate and Cyclopropyl Methoxycarbonyl Metomidate: The Role of the Metabolite. Anesth Analg. 2016 Apr; 122(4):1008-14.
journal title abbreviation: Anesth Analg
publication date: 2016-04-01T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 577922
type: Authorship
linked author: Raines, Douglas
linked information resource: Single Channel Studies Defining Anesthetic Alcohol Action on the 5-HT3A Receptor

Authorship 584891
type: Authorship
linked author: Raines, Douglas
linked information resource: Conformational transitions of the nicotinic acetylcholine receptor as a model for anesthetic actions on ligand-gated ion channels: single and sequential mixing stopped-flow fluorescence studies

Authorship 608379
type: Authorship
linked author: Raines, Douglas
linked information resource: Molecular dipole modulates anesthetic potency

Authorship 616182
type: Authorship
linked author: Raines, Douglas
linked information resource: The Interactions of General Anesthetics with Membranes

Authorship 617430
type: Authorship
linked author: Raines, Douglas
linked information resource: Selective Receptor Actions of Nonhalogenated Alkane Anesthetics

Authorship 558388
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: Anesthetic and nonanesthetic halogenated volatile compounds have dissimilar activities on nicotinic acetylcholine receptor desensitization kinetics.

Authorship 582658
type: Authorship
linked author: Raines, Douglas
linked information resource: Human GABAA receptor enhancement by volatile aromatic anesthetics correlates inversely with NMDA receptor inhibition

Authorship 590502
type: Authorship
linked author: Raines, Douglas
linked information resource: Luminescence quenching of Ruthenium (II) photosynthesizers by Cu (II) in triton surfactant media

Authorship 594355
type: Authorship
linked author: Raines, Douglas
linked information resource: Nonhalogenated alkane anesthetics act with specificity on ligand-gated ion channels

Authorship 594749
type: Authorship
linked author: Raines, Douglas
linked information resource: Nonanesthetic Haloalkanes and Nicotinic Acetylcholine Receptor Desensitization Kinetics

Associate Professor
sort order: 1
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Lecturer
sort order: 3
type: Faculty Rank

Authorship 598917
type: Authorship
linked author: Raines, Douglas
linked information resource: Etomidate Analogues with Improved Pharmacokinetic and Pharmacodynamic Properties

Authorship 609703
type: Authorship
linked author: Raines, Douglas
linked information resource: Kinetics of anesthetic-induced conformational transitions in a four-alpha-helix bundle protein

Authorship 612589
type: Authorship
linked author: Raines, Douglas
linked information resource: Rapid Agonist Binding Studies of the Nicotinic Acetylcholine Receptor

Authorship 584191
type: Authorship
linked author: Raines, Douglas
linked information resource: Volatile anesthetics enhance the open probability of 5-HT3A channels

Authorship 594524
type: Authorship
linked author: Raines, Douglas
linked information resource: Lipids, vesicles, and local anesthetic activity

Authorship 596655
type: Authorship
linked author: Raines, Douglas
linked information resource: Ethanol disrupts slow motions of the protein-associated lipid near the surface of acetylcholine receptors

Authorship 602336
type: Authorship
linked author: Raines, Douglas
linked information resource: 5-HT3A receptor kinetics: agonist and anesthetic action

Authorship 609230
type: Authorship
linked author: Raines, Douglas
linked information resource: General anesthethetic action on 5-HT3 receptors: influence of subunit composition

Authorship 620609
type: Authorship
linked author: Raines, Douglas
linked information resource: Inhibition of alpha4beta2 rat neuronal nicotinic receptors by nonhalogenated alkane anesthetics and perhalogenated alkane nonimmobilizers

Authorship 78778
type: Authorship
author rank in publication: 5
linked author: Raines, Douglas
linked information resource: Photosensitivity and perioperative polyneuropathy complicating orthotopic liver transplantation in a patient with erythropoietic protoporphyria.

Authorship 85316
type: Authorship
author rank in publication: 5
linked author: Raines, Douglas
linked information resource: Do N-methyl-D-aspartate receptors mediate the capacity of inhaled anesthetics to suppress the temporal summation that contributes to minimum alveolar concentration?

Authorship 597622
type: Authorship
linked author: Raines, Douglas
linked information resource: The Molecular Basis of NMDA Receptor Inhibition by Aromatic Volatile General Anesthetics

Authorship 606850
type: Authorship
linked author: Raines, Douglas
linked information resource: Improving billing effectiveness with automated anesthesia information management

Authorship 522341
type: Authorship
author rank in publication: 2
linked author: Raines, Douglas
linked information resource: The effect of general anesthetics on the dynamics of phosphatidylcholine-acetylcholine receptor interactions in reconstituted vesicles.

Authorship 580312
type: Authorship
linked author: Raines, Douglas
linked information resource: Isoflurane increases the apparent affinity of acetylcholine for the nicotinic acetylcholine receptor resting state

Authorship 601575
type: Authorship
linked author: Raines, Douglas
linked information resource: Modulation of human NMDA receptors by chemically diverse general anesthetics: differential inhibition at 1 MAC

Etomidate Analogues as Safer General Anesthetics
end date: 2018-07-31
principal investigator name: RAINES, DOUGLAS E
start date: 2010-01-01
type: Grant
sponsor award id: R01GM087316

GENERAL ANESTHETICS AND LIPID PROTEIN INTERACTIONS
end date: 2001-02-28
principal investigator name: RAINES, DOUGLAS E
start date: 1996-03-01
type: Grant
sponsor award id: R29GM053481

General Anesthetics and nAcCHOR Agonist Affinity
end date: 2006-03-31
principal investigator name: RAINES, DOUGLAS E
start date: 2001-04-01
type: Grant
sponsor award id: R01GM061927

Preclinical Studies of Carbo-etomidate: An Etomidate Analogue for Use in Sepsis
end date: 2013-03-31
principal investigator name: RAINES, DOUGLAS E
start date: 2010-04-01
type: Grant
sponsor award id: R21DA029253

Authorship 611214
type: Authorship
linked author: Raines, Douglas
linked information resource: Comparison of the molecular bases for NMDA-receptor inhibition versus immobilizing activities of volatile aromatic anesthetics

Principal Investigator
type: Researcher Role
researcher role of: Raines, Douglas
contributes to: General Anesthetics and nAcCHOR Agonist Affinity

Principal Investigator
type: Researcher Role
researcher role of: Raines, Douglas
contributes to: Etomidate Analogues as Safer General Anesthetics

Principal Investigator
type: Researcher Role
researcher role of: Raines, Douglas
contributes to: GENERAL ANESTHETICS AND LIPID PROTEIN INTERACTIONS

Principal Investigator
type: Researcher Role
researcher role of: Raines, Douglas
contributes to: Preclinical Studies of Carbo-etomidate: An Etomidate Analogue for Use in Sepsis

Authorship 616013
type: Authorship
linked author: Raines, Douglas
linked information resource: Intra-anesthetic Problems

Authorship 618205
type: Authorship
linked author: Raines, Douglas
linked information resource: The fluorescent agonist Dns-C6-Cho binds with micromolar affinity to the alpha-delta binding site of the nicotinic acetylcholine receptor resting state

Authorship 65154
type: Authorship
author rank in publication: 3
linked author: Raines, Douglas
linked information resource: Volatile aromatic anesthetics variably impact human gamma-aminobutyric acid type A receptor function.

Authorship 592791
type: Authorship
linked author: Raines, Douglas
linked information resource: Isoflurane Accelerates the Activation and Deactivation Rates of Human 5-HT3A Receptors

Authorship 594137
type: Authorship
linked author: Raines, Douglas
linked information resource: Cation-pi interactions modulate the NMDA receptor potencies of inhaled aromatic anesthetics

Authorship 928628
type: Authorship
author rank in publication: 4
linked author: Raines, Douglas
linked information resource: Sedative-hypnotic Binding to 11ß-hydroxylase.

Sedative-hypnotic Binding to 11ß-hydroxylase.
PubMed Identifier: 27541316
author list: Pejo E, Zhou X, Husain SS, Raines DE
published in: Anesthesiology
information resource reference: Sedative-hypnotic Binding to 11ß-hydroxylase. Anesthesiology. 2016 11; 125(5):943-951.
journal title abbreviation: Anesthesiology
publication date: 2016-11-01T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 429684
type: Authorship
author rank in publication: 4
linked author: Raines, Douglas
linked information resource: Modulation of human 5-hydroxytryptamine type 3AB receptors by volatile anesthetics and n-alcohols.

Authorship 581749
type: Authorship
linked author: Raines, Douglas
linked information resource: Isoflurane's actions on the nicotinic acetylcholine receptor are dependent upon the composition of the lipid bilayer

55 Fruit St
type: Address
address line 1: Massachusetts General Hospital
address line 2: Dept. of Anesthesia
address line 3: 55 Fruit St
city: Boston
postal code: 02114
state or province: MA

Authorship 298336
type: Authorship
author rank in publication: 2
linked author: Raines, Douglas
linked information resource: Anesthetic management for transurethral resection of the bladder in a 74-year-old man with uncorrected tetralogy of Fallot.

Authorship 487352
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: Nonhalogenated alkane anesthetics fail to potentiate agonist actions on two ligand-gated ion channels.

Authorship 950686
type: Authorship
author rank in publication: 1
linked author: Raines, Douglas
linked information resource: Flumazenil Modulation of the ?-Aminobutyric Acid Type A Receptor: Competitive versus Noncompetitive Antagonism at the Agonist-binding Site.

Flumazenil Modulation of the ?-Aminobutyric Acid Type A Receptor: Competitive versus Noncompetitive Antagonism at the Agonist-binding Site.
PubMed Identifier: 28098614
author list: Raines DE
published in: Anesthesiology
information resource reference: Flumazenil Modulation of the ?-Aminobutyric Acid Type A Receptor: Competitive versus Noncompetitive Antagonism at the Agonist-binding Site. Anesthesiology. 2017 02; 126(2):350-351.
journal title abbreviation: Anesthesiology
publication date: 2017-02-01T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 598297
type: Authorship
linked author: Raines, Douglas
linked information resource: Development of a novel probe of drug-protein interactions

Authorship 598981
type: Authorship
linked author: Raines, Douglas
linked information resource: General anesthetic effects on nicotinic acetylcholine receptor conformational states are dependent upon lipid composition

Authorship 607958
type: Authorship
linked author: Raines, Douglas
linked information resource: Modulation of 5-HT3A receptors by n-alcohols and volatile anesthetics is dependent on molecular volume

Authorship 613977
type: Authorship
linked author: Raines, Douglas
linked information resource: Spin-label studies into the effects of ethanol on lipid- protein interactions in reconstituted acetylcholine receptor vesicles

Anesthetic management and outcome following noncardiac surgery in nonparturients with Eisenmenger's physiology.
PubMed Identifier: 8832442
author list: Raines DE, Liberthson RR, Murray JR
published in: Journal of clinical anesthesia
information resource reference: Anesthetic management and outcome following noncardiac surgery in nonparturients with Eisenmenger's physiology. J Clin Anesth. 1996 Aug; 8(5):341-7.
journal title abbreviation: J Clin Anesth
publication date: 1996-08-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Halothane interactions with nicotinic acetylcholine receptor membranes. Steady-state and kinetic studies of intrinsic fluorescence quenching.
PubMed Identifier: 9054266
author list: Raines DE, McClure KB
published in: Anesthesiology
information resource reference: Halothane interactions with nicotinic acetylcholine receptor membranes. Steady-state and kinetic studies of intrinsic fluorescence quenching. Anesthesiology. 1997 Feb; 86(2):476-86.
journal title abbreviation: Anesthesiology
publication date: 1997-02-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Perturbation of lipid and protein structure by general anesthetics: how little is too little?
PubMed Identifier: 10781301
author list: Raines DE
published in: Anesthesiology
information resource reference: Perturbation of lipid and protein structure by general anesthetics: how little is too little? Anesthesiology. 2000 May; 92(5):1492-4.
journal title abbreviation: Anesthesiology
publication date: 2000-05-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Acetylcholine receptors and thresholds for convulsions from flurothyl and 1,2-dichlorohexafluorocyclobutane.
PubMed Identifier: 12456426
author list: Eger EI, Gong D, Xing Y, Raines DE, Flood P
published in: Anesthesia and analgesia
information resource reference: Acetylcholine receptors and thresholds for convulsions from flurothyl and 1,2-dichlorohexafluorocyclobutane. Anesth Analg. 2002 Dec; 95(6):1611-5, table of contents.
journal title abbreviation: Anesth Analg
publication date: 2002-12-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

The alkyl chain dependence of the effect of normal alcohols on agonist-induced nicotinic acetylcholine receptor desensitization kinetics.
PubMed Identifier: 10422948
author list: Raines DE, Zachariah VT
published in: Anesthesiology
information resource reference: The alkyl chain dependence of the effect of normal alcohols on agonist-induced nicotinic acetylcholine receptor desensitization kinetics. Anesthesiology. 1999 Jul; 91(1):222-30.
journal title abbreviation: Anesthesiology
publication date: 1999-07-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Artifactual hypertension due to transducer cable malfunction.
PubMed Identifier: 2042769
author list: Raines DE, Hogue CW, Wickens C, Welch J, Risk SC
published in: Anesthesiology
information resource reference: Artifactual hypertension due to transducer cable malfunction. Anesthesiology. 1991 Jun; 74(6):1149-51.
journal title abbreviation: Anesthesiology
publication date: 1991-06-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

The N-methyl-D-aspartate receptor inhibitory potencies of aromatic inhaled drugs of abuse: evidence for modulation by cation-pi interactions.
PubMed Identifier: 15166258
author list: Raines DE, Gioia F, Claycomb RJ, Stevens RJ
published in: The Journal of pharmacology and experimental therapeutics
information resource reference: The N-methyl-D-aspartate receptor inhibitory potencies of aromatic inhaled drugs of abuse: evidence for modulation by cation-pi interactions. J Pharmacol Exp Ther. 2004 Oct; 311(1):14-21.
journal title abbreviation: J Pharmacol Exp Ther
publication date: 2004-05-27T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Agonist binding and affinity state transitions in reconstituted nicotinic acetylcholine receptors revealed by single and sequential mixing stopped-flow fluorescence spectroscopies.
PubMed Identifier: 9814855
author list: Raines DE, Krishnan NS
published in: Biochimica et biophysica acta
information resource reference: Agonist binding and affinity state transitions in reconstituted nicotinic acetylcholine receptors revealed by single and sequential mixing stopped-flow fluorescence spectroscopies. Biochim Biophys Acta. 1998 Sep 23; 1374(1-2):83-93.
journal title abbreviation: Biochim Biophys Acta
publication date: 1998-09-23T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

NMDA receptor inhibitory potencies of volatile aromatic anesthetics: the role of cation-pi interactions
author list: Raines DE, Gioia, FW, Claycomb RJ
published in: Anesthesiology
information resource reference: NMDA receptor inhibitory potencies of volatile aromatic anesthetics: the role of cation-pi interactions. Anesthesiology. 2003; A-109.
publication date: 2003-01-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Luminescence quenching of Ruthenium (II) photosynthesizers by Cu (II) in triton surfactant media
author list: Snyder SW, Raines DE, Rieger PT, Demas DN, Degraff BA
published in: Langmuir
information resource reference: Luminescence quenching of Ruthenium (II) photosynthesizers by Cu (II) in triton surfactant media. Langmuir. 1985; 1:548-52.
publication date: 1985-01-01T00:00:00
year: 1985
type: Academic Article
type: Article
type: Document
type: Information Resource

Modulation of 5-HT3A receptors by n-alcohols and volatile anesthetics is dependent on molecular volume
author list: Stevens RJ, Rusch D, Davies PA, Raines DE
published in: Biophysical Journal
information resource reference: Modulation of 5-HT3A receptors by n-alcohols and volatile anesthetics is dependent on molecular volume. Biophysical Journal. 2004.
publication date: 2004-01-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Modulation of GABA(A) receptor function by nonhalogenated alkane anesthetics: the effects on agonist enhancement, direct activation, and inhibition.
PubMed Identifier: 12505935
author list: Raines DE, Claycomb RJ, Forman SA
published in: Anesthesia and analgesia
information resource reference: Modulation of GABA(A) receptor function by nonhalogenated alkane anesthetics: the effects on agonist enhancement, direct activation, and inhibition. Anesth Analg. 2003 Jan; 96(1):112-8, table of contents.
journal title abbreviation: Anesth Analg
publication date: 2003-01-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Development of a novel probe for measuring drug binding to the F1*S variant of human alpha 1-acid glycoprotein.
PubMed Identifier: 11745793
author list: Cogswell LP, Raines DE, Parekh S, Jonas O, Maggio JE, Strichartz GR
published in: Journal of pharmaceutical sciences
information resource reference: Development of a novel probe for measuring drug binding to the F1*S variant of human alpha 1-acid glycoprotein. J Pharm Sci. 2001 Sep; 90(9):1407-23.
journal title abbreviation: J Pharm Sci
publication date: 2001-09-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Increases in spinal cerebrospinal fluid potassium concentration do not increase isoflurane minimum alveolar concentration in rats.
PubMed Identifier: 18713900
author list: Shnayderman D, Laster MJ, Eger EI, Oh I, Zhang Y, Jinks SL, Antognini JF, Raines DE
published in: Anesthesia and analgesia
information resource reference: Increases in spinal cerebrospinal fluid potassium concentration do not increase isoflurane minimum alveolar concentration in rats. Anesth Analg. 2008 Sep; 107(3):879-84.
journal title abbreviation: Anesth Analg
publication date: 2008-09-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Aprotinin administration and pulmonary thromboembolism during orthotopic liver transplantation: report of two cases.
PubMed Identifier: 11375816
author list: Fitzsimons MG, Peterfreund RA, Raines DE
published in: Anesthesia and analgesia
information resource reference: Aprotinin administration and pulmonary thromboembolism during orthotopic liver transplantation: report of two cases. Anesth Analg. 2001 Jun; 92(6):1418-21.
journal title abbreviation: Anesth Analg
publication date: 2001-06-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Time-dependent binding of paramagnetic and fluorescent hydrophobic ions to the acetylcholine receptor from Torpedo.
PubMed Identifier: 2820466
author list: Hartsel SC, Moore CR, Raines DE, Cafiso DS
published in: Biochemistry
information resource reference: Time-dependent binding of paramagnetic and fluorescent hydrophobic ions to the acetylcholine receptor from Torpedo. Biochemistry. 1987 Jun 16; 26(12):3253-60.
journal title abbreviation: Biochemistry
publication date: 1987-06-16T00:00:00
year: 1987
type: Academic Article
type: Article
type: Document
type: Information Resource

Improving billing effectiveness with automated anesthesia information management
author list: Sandberg WS, Spring S, Raines DE
published in: 53rd Annual Meeting of the Association of University
information resource reference: Improving billing effectiveness with automated anesthesia information management. 53rd Annual Meeting of the Association of University. 2006.
publication date: 2006-05-10T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Transient low-affinity agonist binding to Torpedo postsynaptic membranes resolved by using sequential mixing stopped-flow fluorescence spectroscopy.
PubMed Identifier: 9454586
author list: Raines DE, Krishnan NS
published in: Biochemistry
information resource reference: Transient low-affinity agonist binding to Torpedo postsynaptic membranes resolved by using sequential mixing stopped-flow fluorescence spectroscopy. Biochemistry. 1998 Jan 20; 37(3):956-64.
journal title abbreviation: Biochemistry
publication date: 1998-01-20T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration.
PubMed Identifier: 12933393
author list: Sonner JM, Antognini JF, Dutton RC, Flood P, Gray AT, Harris RA, Homanics GE, Kendig J, Orser B, Raines DE, Trudell J, Vissel B, Eger EI
published in: Anesthesia and analgesia
information resource reference: Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration. Anesth Analg. 2003 Sep; 97(3):718-740.
journal title abbreviation: Anesth Analg
publication date: 2003-09-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Differential effects of serotonin and dopamine on human 5-HT3A receptor kinetics: interpretation within an allosteric kinetic model.
PubMed Identifier: 18045909
author list: Solt K, Ruesch D, Forman SA, Davies PA, Raines DE
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: Differential effects of serotonin and dopamine on human 5-HT3A receptor kinetics: interpretation within an allosteric kinetic model. J Neurosci. 2007 Nov 28; 27(48):13151-60.
journal title abbreviation: J Neurosci
publication date: 2007-11-28T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Automated documentation error detection and notification improves anesthesia billing performance.
PubMed Identifier: 17197858
author list: Spring SF, Sandberg WS, Anupama S, Walsh JL, Driscoll WD, Raines DE
published in: Anesthesiology
information resource reference: Automated documentation error detection and notification improves anesthesia billing performance. Anesthesiology. 2007 Jan; 106(1):157-63.
journal title abbreviation: Anesthesiology
publication date: 2007-01-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Isoflurane increases the apparent agonist affinity of the nicotinic acetylcholine receptor.
PubMed Identifier: 9915322
author list: Raines DE, Zachariah VT
published in: Anesthesiology
information resource reference: Isoflurane increases the apparent agonist affinity of the nicotinic acetylcholine receptor. Anesthesiology. 1999 Jan; 90(1):135-46.
journal title abbreviation: Anesthesiology
publication date: 1999-01-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Is a new paradigm needed to explain how inhaled anesthetics produce immobility?
PubMed Identifier: 18713892
author list: Eger EI, Raines DE, Shafer SL, Hemmings HC, Sonner JM
published in: Anesthesia and analgesia
information resource reference: Is a new paradigm needed to explain how inhaled anesthetics produce immobility? Anesth Analg. 2008 Sep; 107(3):832-48.
journal title abbreviation: Anesth Analg
publication date: 2008-09-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Single Channel Studies Defining Anesthetic Alcohol Action on the 5-HT3A Receptor
author list: Daives PA, Solt K, Raines DE
published in: Anesthesiology
information resource reference: Single Channel Studies Defining Anesthetic Alcohol Action on the 5-HT3A Receptor. Anesthesiology. 2007; A355.
publication date: 2007-10-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Rapid Agonist Binding Studies of the Nicotinic Acetylcholine Receptor
author list: Raines DE
published in: Molecular and Basic Mechanisms of Anesthesia
information resource reference: Rapid Agonist Binding Studies of the Nicotinic Acetylcholine Receptor. Molecular and Basic Mechanisms of Anesthesia. 2002.
publication date: 2002-01-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

A hydrophobic inhibitor of the nicotinic acetylcholine receptor acts on the resting state.
PubMed Identifier: 7803400
author list: Wu G, Raines DE, Miller KW
published in: Biochemistry
information resource reference: A hydrophobic inhibitor of the nicotinic acetylcholine receptor acts on the resting state. Biochemistry. 1994 Dec 27; 33(51):15375-81.
journal title abbreviation: Biochemistry
publication date: 1994-12-27T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

The role of charge in lipid selectivity for the nicotinic acetylcholine receptor.
PubMed Identifier: 8386010
author list: Raines DE, Miller KW
published in: Biophysical journal
information resource reference: The role of charge in lipid selectivity for the nicotinic acetylcholine receptor. Biophys J. 1993 Mar; 64(3):632-41.
journal title abbreviation: Biophys J
publication date: 1993-03-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Anesthetic and nonanesthetic halogenated volatile compounds have dissimilar activities on nicotinic acetylcholine receptor desensitization kinetics.
PubMed Identifier: 8659795
author list: Raines DE
published in: Anesthesiology
information resource reference: Anesthetic and nonanesthetic halogenated volatile compounds have dissimilar activities on nicotinic acetylcholine receptor desensitization kinetics. Anesthesiology. 1996 Mar; 84(3):663-71.
journal title abbreviation: Anesthesiology
publication date: 1996-03-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Hexafluorobenzene acts in the spinal cord, whereas o-difluorobenzene acts in both brain and spinal cord, to produce immobility.
PubMed Identifier: 17377088
author list: Antognini JF, Raines DE, Solt K, Barter LS, Atherley RJ, Bravo E, Laster MJ, Jankowska K, Eger EI
published in: Anesthesia and analgesia
information resource reference: Hexafluorobenzene acts in the spinal cord, whereas o-difluorobenzene acts in both brain and spinal cord, to produce immobility. Anesth Analg. 2007 Apr; 104(4):822-8.
journal title abbreviation: Anesth Analg
publication date: 2007-04-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Electroencephalographic recovery, hypnotic emergence, and the effects of metabolite after continuous infusions of a rapidly metabolized etomidate analog in rats.
PubMed Identifier: 22417966
author list: Pejo E, Ge R, Banacos N, Cotten JF, Husain SS, Raines DE
published in: Anesthesiology
information resource reference: Electroencephalographic recovery, hypnotic emergence, and the effects of metabolite after continuous infusions of a rapidly metabolized etomidate analog in rats. Anesthesiology. 2012 May; 116(5):1057-65.
journal title abbreviation: Anesthesiology
publication date: 2012-05-01T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

The enhancement of proton/hydroxyl flow across lipid vesicles by inhalation anesthetics.
PubMed Identifier: 2536253
author list: Raines DE, Cafiso DS
published in: Anesthesiology
information resource reference: The enhancement of proton/hydroxyl flow across lipid vesicles by inhalation anesthetics. Anesthesiology. 1989 Jan; 70(1):57-63.
journal title abbreviation: Anesthesiology
publication date: 1989-01-01T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Etomidate Analogues with Improved Pharmacokinetic and Pharmacodynamic Properties
author list: Raines DE, Forman SA, Husain SS, Miller KW
published in: Etomidate Analogues with Improved Pharmacokinetic and Pharmacodynamic Properties
information resource reference: Etomidate Analogues with Improved Pharmacokinetic and Pharmacodynamic Properties. 2008.
publication date: 2008-03-31T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1006262
type: Authorship
author rank in publication: 8
linked author: Raines, Douglas
linked information resource: Competitive Antagonism of Anesthetic Action at the ?-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy.

Competitive Antagonism of Anesthetic Action at the ?-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy.
PubMed Identifier: 28857763
author list: Ma C, Pejo E, McGrath M, Jayakar SS, Zhou X, Miller KW, Cohen JB, Raines DE
published in: Anesthesiology
information resource reference: Competitive Antagonism of Anesthetic Action at the ?-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy. Anesthesiology. 2017 11; 127(5):824-837.
journal title abbreviation: Anesthesiology
publication date: 2017-11-01T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhibition of Human 5-HT3A and 5-HT3AB Receptors by Etomidate, Propofol and Pentobarbital
author list: Ruesch D, Schuster A, Wulf H, Braun HA, Raines DE
published in: Anesthesiology
information resource reference: Inhibition of Human 5-HT3A and 5-HT3AB Receptors by Etomidate, Propofol and Pentobarbital. Anesthesiology. 2007; A355.
publication date: 2007-10-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

5-HT3A receptor kinetics: agonist and anesthetic action
author list: Raines DE, Rusch D, Davies PA
published in: International Congress Series
information resource reference: 5-HT3A receptor kinetics: agonist and anesthetic action. International Congress Series. 2005; 247-50.
publication date: 2005-01-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels.
PubMed Identifier: 20704351
author list: Husain SS, Stewart D, Desai R, Hamouda AK, Li SG, Kelly E, Dostalova Z, Zhou X, Cotten JF, Raines DE, Olsen RW, Cohen JB, Forman SA, Miller KW
published in: Journal of medicinal chemistry
information resource reference: p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels. J Med Chem. 2010 Sep 09; 53(17):6432-44.
journal title abbreviation: J Med Chem
publication date: 2010-09-09T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Neural Mechanisms of Anesthesia
author list: Antognini JF, Carstens EE, Raines DE
published in: Neural Mechanisms of Anesthesia
information resource reference: Neural Mechanisms of Anesthesia. 2002; 466.
publication date: 2002-01-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Effects of Etomidate and Photoactivatable Etomidate Analogues on Adrenal Cortisol Synthesis
author list: Lymar DS, Liu A, Cotten JF, Forman SA, Husain SS, Miller KW, Raines DE
published in: Anesthesiology
information resource reference: Effects of Etomidate and Photoactivatable Etomidate Analogues on Adrenal Cortisol Synthesis. Anesthesiology. 2008; A8.
publication date: 2008-10-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Competitive Antagonists for General Anesthetics: A New Class of Drugs for Improving Patient Care and Advancing Scientific Research
end date: 2022-01-31
principal investigator name: RAINES, DOUGLAS E
start date: 2017-04-05
type: Grant
sponsor award id: R01GM122806

Principal Investigator
type: Researcher Role
researcher role of: Raines, Douglas
contributes to: Competitive Antagonists for General Anesthetics: A New Class of Drugs for Improving Patient Care and Advancing Scientific Research

Anesthetic management for transurethral resection of the bladder in a 74-year-old man with uncorrected tetralogy of Fallot.
PubMed Identifier: 15896587
author list: Shaff DA, Raines DE, Vidal Melo MF, King ME, Misra S, Chen LL
published in: Journal of clinical anesthesia
information resource reference: Anesthetic management for transurethral resection of the bladder in a 74-year-old man with uncorrected tetralogy of Fallot. J Clin Anesth. 2005 May; 17(3):198-201.
journal title abbreviation: J Clin Anesth
publication date: 2005-05-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Pharmacological studies of methoxycarbonyl etomidate's carboxylic acid metabolite.
PubMed Identifier: 22052979
author list: Ge RL, Pejo E, Haburcak M, Husain SS, Forman SA, Raines DE
published in: Anesthesia and analgesia
information resource reference: Pharmacological studies of methoxycarbonyl etomidate's carboxylic acid metabolite. Anesth Analg. 2012 Aug; 115(2):305-8.
journal title abbreviation: Anesth Analg
publication date: 2011-11-03T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Ethanol disrupts slow motions of the protein-associated lipid near the surface of acetylcholine receptors
author list: Dalton LA, Raines DE, Miller KW
published in: Biophysical Journal
information resource reference: Ethanol disrupts slow motions of the protein-associated lipid near the surface of acetylcholine receptors. Biophysical Journal. 1994.
publication date: 1994-01-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

MOC-etomidate: A Novel, Rapidly Metabolized and Ultra-Short-Acting Etomidate Analogue
author list: Cotten JF, Husain SS, Forman SA, Miller KW, Kelly EW, Nguyen HH Raines DE
published in: Anesthesiology
information resource reference: MOC-etomidate: A Novel, Rapidly Metabolized and Ultra-Short-Acting Etomidate Analogue. Anesthesiology. 2008; A8.
publication date: 2008-10-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Contrasting effects of NMDA receptor inhibition by MK-801 on the immobilizing potencies of aromatic and non-aromatic inhaled anesthetics
author list: Solt K, Liao M, Eger EI, Laster M, Raines DE
published in: Anesthesiology
information resource reference: Contrasting effects of NMDA receptor inhibition by MK-801 on the immobilizing potencies of aromatic and non-aromatic inhaled anesthetics. Anesthesiology. 2005; A663.
publication date: 2005-01-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Nonhalogenated alkane anesthetics fail to potentiate agonist actions on two ligand-gated ion channels.
PubMed Identifier: 11506122
author list: Raines DE, Claycomb RJ, Scheller M, Forman SA
published in: Anesthesiology
information resource reference: Nonhalogenated alkane anesthetics fail to potentiate agonist actions on two ligand-gated ion channels. Anesthesiology. 2001 Aug; 95(2):470-7.
journal title abbreviation: Anesthesiology
publication date: 2001-08-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Nonhalogenated anesthetic alkanes and perhalogenated nonimmobilizing alkanes inhibit alpha(4)beta(2) neuronal nicotinic acetylcholine receptors.
PubMed Identifier: 12198040
author list: Raines DE, Claycomb RJ, Forman SA
published in: Anesthesia and analgesia
information resource reference: Nonhalogenated anesthetic alkanes and perhalogenated nonimmobilizing alkanes inhibit alpha(4)beta(2) neuronal nicotinic acetylcholine receptors. Anesth Analg. 2002 Sep; 95(3):573-7, table of contents.
journal title abbreviation: Anesth Analg
publication date: 2002-09-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Differential modulation of human N-methyl-D-aspartate receptors by structurally diverse general anesthetics.
PubMed Identifier: 16632818
author list: Solt K, Eger EI, Raines DE
published in: Anesthesia and analgesia
information resource reference: Differential modulation of human N-methyl-D-aspartate receptors by structurally diverse general anesthetics. Anesth Analg. 2006 May; 102(5):1407-11.
journal title abbreviation: Anesth Analg
publication date: 2006-05-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

The role of electrostatic interactions in governing anesthetic action on the torpedo nicotinic acetylcholine receptor.
PubMed Identifier: 12145051
author list: Raines DE, Claycomb RJ
published in: Anesthesia and analgesia
information resource reference: The role of electrostatic interactions in governing anesthetic action on the torpedo nicotinic acetylcholine receptor. Anesth Analg. 2002 Aug; 95(2):356-61, table of contents.
journal title abbreviation: Anesth Analg
publication date: 2002-08-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Contrasting roles of the N-methyl-D-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics.
PubMed Identifier: 16632817
author list: Eger EI, Liao M, Laster MJ, Won A, Popovich J, Raines DE, Solt K, Dutton RC, Cobos FV, Sonner JM
published in: Anesthesia and analgesia
information resource reference: Contrasting roles of the N-methyl-D-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics. Anesth Analg. 2006 May; 102(5):1397-406.
journal title abbreviation: Anesth Analg
publication date: 2006-05-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Modulation of human NMDA receptors by chemically diverse general anesthetics: differential inhibition at 1 MAC
author list: Solt K, Eger EI, Raines DE
published in: Anesthesiology
information resource reference: Modulation of human NMDA receptors by chemically diverse general anesthetics: differential inhibition at 1 MAC. Anesthesiology. 2005; A683.
publication date: 2005-01-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Lipids, vesicles, and local anesthetic activity
author list: Wills MH, Mosciki JS, Raines DE, Cafiso D, Difazio CA
published in: Regional Anesthesia
information resource reference: Lipids, vesicles, and local anesthetic activity. Regional Anesthesia. 1987; 13(IS):59.
publication date: 1987-01-01T00:00:00
year: 1987
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular mechanisms of general anesthesia. in the Harvard Electronic Anesthesia Library. Bailin M, Bergeron B, Dershwitz M. eds
author list: Raines DE, Forman, SA
published in: Molecular mechanisms of general anesthesia. in the Harvard Electronic Anesthesia Library. Bailin M, Bergeron B, Dershwitz M. eds.
information resource reference: Molecular mechanisms of general anesthesia. in the Harvard Electronic Anesthesia Library. Bailin M, Bergeron B, Dershwitz M. eds. 2001.
publication date: 2001-01-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Modulation of human 5-hydroxytryptamine type 3AB receptors by volatile anesthetics and n-alcohols.
PubMed Identifier: 15831437
author list: Stevens R, Rüsch D, Solt K, Raines DE, Davies PA
published in: The Journal of pharmacology and experimental therapeutics
information resource reference: Modulation of human 5-hydroxytryptamine type 3AB receptors by volatile anesthetics and n-alcohols. J Pharmacol Exp Ther. 2005 Jul; 314(1):338-45.
journal title abbreviation: J Pharmacol Exp Ther
publication date: 2005-04-14T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Development of a novel probe of drug-protein interactions
author list: Cogswell LP, Mok W-M, Parekh JE, Maggio JE, Raines DE, Strichartz GR
published in: Biophysical Journal
information resource reference: Development of a novel probe of drug-protein interactions. Biophysical Journal. 1999.
publication date: 1999-01-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Plus Ca Change
author list: Forman SA, Raines DE
published in: Anesthesiology
information resource reference: Plus Ca Change. Anesthesiology. 1999; 90:632-633.
publication date: 1999-01-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Co-expression of the 5-HT3B subunit attenuates general anesthetic action on 5-HT3 receptor channel gating efficacy
author list: Solt K, Stevens R, Davies, PA, Raines DE
published in: Anesthesiology
information resource reference: Co-expression of the 5-HT3B subunit attenuates general anesthetic action on 5-HT3 receptor channel gating efficacy. Anesthesiology. 2005; A664.
publication date: 2005-01-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Management of the parturient with hepatic disease
author list: Weinstein L, Raines, DE
published in: Management of the parturient with hepatic disease
information resource reference: Management of the parturient with hepatic disease. 2005.
publication date: 2005-01-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Human GABAA receptor enhancement by volatile aromatic anesthetics correlates inversely with NMDA receptor inhibition
author list: Solt K, Kelly EW, Raines DE
published in: Association of University Anesthesiologists
information resource reference: Human GABAA receptor enhancement by volatile aromatic anesthetics correlates inversely with NMDA receptor inhibition. Association of University Anesthesiologists. 2007.
publication date: 2007-04-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1031971
type: Authorship
author rank in publication: 7
linked author: Raines, Douglas
linked information resource: Sources of Variation in Anesthetic Drug Costs.

Authorship 1033923
type: Authorship
author rank in publication: 3
linked author: Raines, Douglas
linked information resource: Dimethoxy-etomidate: A Nonhypnotic Etomidate Analog that Potently Inhibits Steroidogenesis.

Dimethoxy-etomidate: A Nonhypnotic Etomidate Analog that Potently Inhibits Steroidogenesis.
PubMed Identifier: 29203576
author list: McGrath M, Ma C, Raines DE
published in: The Journal of pharmacology and experimental therapeutics
information resource reference: Dimethoxy-etomidate: A Nonhypnotic Etomidate Analog that Potently Inhibits Steroidogenesis. J Pharmacol Exp Ther. 2018 02; 364(2):229-237.
journal title abbreviation: J Pharmacol Exp Ther
publication date: 2017-12-04T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Sources of Variation in Anesthetic Drug Costs.
PubMed Identifier: 29256939
author list: Wanderer JP, Nelson SE, Hester DL, Shotwell M, Sandberg WS, Anderson-Dam J, Raines DE, Ehrenfeld JM
published in: Anesthesia and analgesia
information resource reference: Sources of Variation in Anesthetic Drug Costs. Anesth Analg. 2018 04; 126(4):1241-1248.
journal title abbreviation: Anesth Analg
publication date: 2018-04-01T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhibition of human alpha4beta2 neuronal nicotinic acetylcholine receptors by volatile aromatic anesthetics depends on drug hydrophobicity.
PubMed Identifier: 19917625
author list: Solt K, Kelly EW, Cotten JF, Raines DE
published in: Anesthesia and analgesia
information resource reference: Inhibition of human alpha4beta2 neuronal nicotinic acetylcholine receptors by volatile aromatic anesthetics depends on drug hydrophobicity. Anesth Analg. 2010 Feb 01; 110(2):455-60.
journal title abbreviation: Anesth Analg
publication date: 2009-11-16T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Isoflurane increases the apparent affinity of acetylcholine for the nicotinic acetylcholine receptor resting state
author list: Raines DE, Zachariah ZT
published in: Anesthesiology
information resource reference: Isoflurane increases the apparent affinity of acetylcholine for the nicotinic acetylcholine receptor resting state. Anesthesiology. 1998.
publication date: 1998-01-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Nonhalogenated alkane anesthetics act with specificity on ligand-gated ion channels
author list: Raines DE, Claycomb RJ, Scheller, M., Forman SA
published in: Anesthesiology
information resource reference: Nonhalogenated alkane anesthetics act with specificity on ligand-gated ion channels. Anesthesiology. 2001; A-116.
publication date: 2001-01-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Functional Aspects of Acetylcholine Receptor-Lipid Interactions
author list: Rankin SA, Raines DE, Dalton LA, Miller KW
published in: Protein-Lipid Interactions
information resource reference: Functional Aspects of Acetylcholine Receptor-Lipid Interactions. Protein-Lipid Interactions. 1993; (79):213-229.
publication date: 1993-01-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Volatile aromatic anesthetics variably impact human gamma-aminobutyric acid type A receptor function.
PubMed Identifier: 17959956
author list: Kelly EW, Solt K, Raines DE
published in: Anesthesia and analgesia
information resource reference: Volatile aromatic anesthetics variably impact human gamma-aminobutyric acid type A receptor function. Anesth Analg. 2007 Nov; 105(5):1287-92, table of contents.
journal title abbreviation: Anesth Analg
publication date: 2007-11-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Conformational transitions of the nicotinic acetylcholine receptor as a model for anesthetic actions on ligand-gated ion channels: single and sequential mixing stopped-flow fluorescence studies.
PubMed Identifier: 10049137
author list: Raines DE
published in: Toxicology letters
information resource reference: Conformational transitions of the nicotinic acetylcholine receptor as a model for anesthetic actions on ligand-gated ion channels: single and sequential mixing stopped-flow fluorescence studies. Toxicol Lett. 1998 Nov 23; 100-101:163-8.
journal title abbreviation: Toxicol Lett
publication date: 1998-11-23T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

General anesthetic-induced channel gating enhancement of 5-hydroxytryptamine type 3 receptors depends on receptor subunit composition.
PubMed Identifier: 16081679
author list: Solt K, Stevens RJ, Davies PA, Raines DE
published in: The Journal of pharmacology and experimental therapeutics
information resource reference: General anesthetic-induced channel gating enhancement of 5-hydroxytryptamine type 3 receptors depends on receptor subunit composition. J Pharmacol Exp Ther. 2005 Nov; 315(2):771-6.
journal title abbreviation: J Pharmacol Exp Ther
publication date: 2005-08-04T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels.
PubMed Identifier: 16884293
author list: Husain SS, Nirthanan S, Ruesch D, Solt K, Cheng Q, Li GD, Arevalo E, Olsen RW, Raines DE, Forman SA, Cohen JB, Miller KW
published in: Journal of medicinal chemistry
information resource reference: Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels. J Med Chem. 2006 Aug 10; 49(16):4818-25.
journal title abbreviation: J Med Chem
publication date: 2006-08-10T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Modifying methoxycarbonyl etomidate inter-ester spacer optimizes in vitro metabolic stability and in vivo hypnotic potency and duration of action.
PubMed Identifier: 22929736
author list: Husain SS, Pejo E, Ge R, Raines DE
published in: Anesthesiology
information resource reference: Modifying methoxycarbonyl etomidate inter-ester spacer optimizes in vitro metabolic stability and in vivo hypnotic potency and duration of action. Anesthesiology. 2012 Nov; 117(5):1027-36.
journal title abbreviation: Anesthesiology
publication date: 2012-11-01T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Cholesterol modulates anesthetic sensitivity in reconstituted nicotinic acetylcholine receptors
author list: Raines DE, Krishnan, NS, Miller KW
published in: Biophysical Journal
information resource reference: Cholesterol modulates anesthetic sensitivity in reconstituted nicotinic acetylcholine receptors. Biophysical Journal. 1997.
publication date: 1997-01-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

General anesthethetic action on 5-HT3 receptors: influence of subunit composition
author list: Solt K, Stevens RJ, Rusch D, Raines DE, Davies PA.
published in: International Congress Series
information resource reference: General anesthethetic action on 5-HT3 receptors: influence of subunit composition. International Congress Series. 2005; 79-84.
publication date: 2005-01-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Potential-dependent phase partitioning of fluorescent hydrophobic ions in phospholipid vesicles.
PubMed Identifier: 6530698
author list: Raines DE, Cafiso DS
published in: The Journal of membrane biology
information resource reference: Potential-dependent phase partitioning of fluorescent hydrophobic ions in phospholipid vesicles. J Membr Biol. 1984; 82(3):241-7.
journal title abbreviation: J Membr Biol
publication date: 1984-01-01T00:00:00
year: 1984
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular dipole modulates anesthetic potency
author list: Raines DE, Claycomb RJ
published in: Biophysical Journal
information resource reference: Molecular dipole modulates anesthetic potency. Biophysical Journal. 2001; A-117.
publication date: 2001-01-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Nonanesthetic volatile drugs obey the Meyer-Overton correlation in two molecular protein site models.
PubMed Identifier: 9637648
author list: Forman SA, Raines DE
published in: Anesthesiology
information resource reference: Nonanesthetic volatile drugs obey the Meyer-Overton correlation in two molecular protein site models. Anesthesiology. 1998 Jun; 88(6):1535-48.
journal title abbreviation: Anesthesiology
publication date: 1998-06-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource