GMS7GaneshShankarGanesh Mani Shankar, M.D., Ph.D.42.33837200000000-71.1032690000000032912Shankar, GaneshMani617/726-5143Assistant Professor of Neurosurgerycatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 1058277229652780Choi BD, Shankar GM, Sivaganesan A, Van Beaver LA, Oh K, Shin JHSpineImplication of Biomarker Mutations for Predicting Survival in Patients With Metastatic Lung Cancer to the Spine. Spine (Phila Pa 1976). 2018 Nov 01; 43(21):E1274-E1280.Spine (Phila Pa 1976)2018-11-01T00:00:002018Implication of Biomarker Mutations for Predicting Survival in Patients With Metastatic Lung Cancer to the Spine.Authorship 1061068229680441Sastry RA, Shankar GM, Gerstner ER, Curry WTJournal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaThe impact of surgery on survival after progression of glioblastoma: A retrospective cohort analysis of a contemporary patient population. J Clin Neurosci. 2018 Jul; 53:41-47.J Clin Neurosci2018-04-19T00:00:002018The impact of surgery on survival after progression of glioblastoma: A retrospective cohort analysis of a contemporary patient population.20403962Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG, Walsh DMBrain : a journal of neurologyThe presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Brain. 2010 May; 133(Pt 5):1328-41.Brain2010-04-19T00:00:002010The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia.21987540Shepardson NE, Shankar GM, Selkoe DJArchives of neurologyCholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies. Arch Neurol. 2011 Oct; 68(10):1239-44.Arch Neurol2011-10-01T00:00:002011Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies.Authorship 1087037130082399Shankar GM, Kirtane AR, Miller JJ, Mazdiyasni H, Rogner J, Tai T, Williams EA, Higuchi F, Juratli TA, Tateishi K, Koerner MVA, Tummala SS, Fink AL, Penson T, Schmidt SP, Wojtkiewicz GR, Baig A, Francis JM, Rinne ML, Batten JM, Batchelor TT, Brastianos PK, Curry WT, Barker FG, Jordan JT, Iafrate AJ, Chi AS, Lennerz JK, Meyerson M, Langer R, Wakimoto H, Traverso G, Cahill DPProceedings of the National Academy of Sciences of the United States of AmericaGenotype-targeted local therapy of glioma. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):E8388-E8394.Proc Natl Acad Sci U S A2018-08-06T00:00:002018Genotype-targeted local therapy of glioma.30123936Juratli TA, McCabe D, Nayyar N, Williams EA, Silverman IM, Tummala SS, Fink AL, Baig A, Martinez-Lage M, Selig MK, Bihun IV, Shankar GM, Penson T, Lastrapes M, Daubner D, Meinhardt M, Hennig S, Kaplan AB, Fujio S, Kuter BM, Bertalan MS, Miller JJ, Batten JM, Ely HA, Christiansen J, Baretton GB, Stemmer-Rachamimov AO, Santagata S, Rivera MN, Barker FG, Schackert G, Wakimoto H, Iafrate AJ, Carter SL, Cahill DP, Brastianos PKActa neuropathologicaDMD genomic deletions characterize a subset of progressive/higher-grade meningiomas with poor outcome. Acta Neuropathol. 2018 11; 136(5):779-792.Acta Neuropathol2018-08-19T00:00:002018DMD genomic deletions characterize a subset of progressive/higher-grade meningiomas with poor outcome.Authorship 108895512Authorship 103048118568035Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJNature medicineAmyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008 Aug; 14(8):837-42.Nat Med2008-06-22T00:00:002008Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.20515359Shankar GM, Chen L, Kim AH, Ross GL, Folkerth RD, Friedlander RMJournal of neurosurgery. SpineComposite ganglioneuroma-paraganglioma of the filum terminale. J Neurosurg Spine. 2010 Jun; 12(6):709-13.J Neurosurg Spine2010-06-01T00:00:002010Composite ganglioneuroma-paraganglioma of the filum terminale.20967581Shankar GM, Welzel AT, McDonald JM, Selkoe DJ, Walsh DMMethods in molecular biology (Clifton, N.J.)Isolation of low-n amyloid ß-protein oligomers from cultured cells, CSF, and brain. Methods Mol Biol. 2011; 670:33-44.Methods Mol Biol2011-01-01T00:00:002011Isolation of low-n amyloid ß-protein oligomers from cultured cells, CSF, and brain.19660551Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, Walsh DMNeurobiology of diseaseBiochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiol Dis. 2009 Nov; 36(2):293-302.Neurobiol Dis2009-08-04T00:00:002009Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life.Authorship 108906617360908Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BLThe Journal of neuroscience : the official journal of the Society for NeuroscienceNatural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci. 2007 Mar 14; 27(11):2866-75.J Neurosci2007-03-14T00:00:002007Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway.18368143Irvine GB, El-Agnaf OM, Shankar GM, Walsh DMMolecular medicine (Cambridge, Mass.)Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases. Mol Med. 2008 Jul-Aug; 14(7-8):451-64.Mol Med2008-07-01T00:00:002008Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases.20428510Li S, Shankar GM, Selkoe DJFrontiers in cellular neuroscienceHow do Soluble Oligomers of Amyloid beta-protein Impair Hippocampal Synaptic Plasticity? Front Cell Neurosci. 2010; 4:5.Front Cell Neurosci2010-03-19T00:00:002010How do Soluble Oligomers of Amyloid beta-protein Impair Hippocampal Synaptic Plasticity?D013125Disorders3187580.583916Spinal NeoplasmsD043222Chemicals & Drugs2604490.773166Ubiquitin ThiolesteraseD016229Chemicals & Drugs59335790.387395Amyloid beta-PeptidesD016543Disorders3698940.530177Central Nervous System NeoplasmsD013120Disorders1662820.79507Spinal Cord NeoplasmsGeneticsMedicineNeurologyOrthopedic SurgeryGastroenterologyOncologyAllergy/ImmunologyChanning Division of Network MedicineBrigham and Women's HospitalDana-Farber Cancer InstituteMassachusetts General HospitalDJS1DennisSelkoeDennis J. Selkoe, M.D.42.33837200000000-71.1032690000000081795Selkoe, DennisVincent and Stella Coates Professor of Neurologic Diseases in the Department of NeurologyLC181LoriChibnikLori Chibnik, Ph.D.42.33837200000000-71.1032690000000059649Chibnik, LoriAssociate Professor of NeurologyPYW1PatrickWenPatrick Yung Chih Wen, M.D.42.33789600000000-71.1072493000000022271Wen, PatrickProfessor of NeurologyWG3WolframGoesslingWolfram Goessling, M.D., Ph.D.42.33837200000000-71.1032690000000069357Goessling, WolframRobert H. Ebert Professor of MedicineDMW2DominicWalshDominic M. Walsh, Ph.D.42.33837200000000-71.1032690000000028637Walsh, DominicLecturer on NeurologySJE2StephenElledgeStephen J. Elledge, Ph.D.42.33837200000000-71.1032690000000032424Elledge, StephenGregor Mendel Professor of Genetics and of Medicine1177selected publications2.245160.00508544324research areas7.312030.0271789120coauthor of49.26038.810460similar toMTW4MichaelWilsonMichael Terry Wilson, M.D.42.33837200000000-71.1032690000000014860Wilson, MichaelAssistant Professor of MedicineTKC6ToniChoueiriToni K. Choueiri, M.D.42.33789600000000-71.1072493000000077491Choueiri, ToniJerome and Nancy Kohlberg Professor of MedicineAuthorship 1385292JHS37JohnShinJohn H Shin, M.D.102649Shin, JohnAssociate Professor of NeurosurgeryPK30PiaWebbPia Kivisakk Webb, M.D., Ph.D.42.33837200000000-71.1032690000000049116Webb, PiaInstructor in NeurologyOA42OssamaAl-MeftyOssama Al-Mefty, M.D.103108Al-Mefty, OssamaLecturer on NeurosurgeryDPC5DanielCahillDaniel P. Cahill, M.D.,Ph.D.7100Cahill, DanielProfessor of Neurosurgerytrue1Assistant Professor of NeurosurgeryAssistant Professor of Neurosurgerytrue1Jerome and Nancy Kohlberg Professor of MedicineJerome and Nancy Kohlberg Professor of Medicinetrue1Professor of NeurologyProfessor of Neurologytrue1Vincent and Stella Coates Professor of Neurologic Diseases in the Department of NeurologyVincent and Stella Coates Professor of Neurologic Diseases in the Department of Neurologytrue1Lecturer on NeurologyLecturer on Neurologytrue1Lecturer on NeurosurgeryLecturer on Neurosurgery31905455Massaad E, Fatima N, Hadzipasic M, Alvarez-Breckenridge C, Shankar GM, Shin JHNeurospinePredictive Analytics in Spine Oncology Research: First Steps, Limitations, and Future Directions. Neurospine. 2019 Dec; 16(4):669-677.Neurospine2019-12-31T00:00:002019Predictive Analytics in Spine Oncology Research: First Steps, Limitations, and Future Directions.31931246Fatima N, Massaad E, Shankar GM, Shin JHWorld neurosurgeryStructural Allograft versus Polyetheretherketone Implants in Patients Undergoing Spinal Fusion Surgery: A Systematic Review and Meta-Analysis. World Neurosurg. 2020 Apr; 136:101-109.World Neurosurg2020-01-10T00:00:002020Structural Allograft versus Polyetheretherketone Implants in Patients Undergoing Spinal Fusion Surgery: A Systematic Review and Meta-Analysis.Authorship 1216726531938967Fatima N, Barra ME, Roberts RJ, Massaad E, Hadzipasic M, Shankar GM, Shin JHNeurosurgical reviewAdvances in surgical hemostasis: a comprehensive review and meta-analysis on topical tranexamic acid in spinal deformity surgery. Neurosurg Rev. 2021 Feb; 44(1):163-175.Neurosurg Rev2020-01-14T00:00:002020Advances in surgical hemostasis: a comprehensive review and meta-analysis on topical tranexamic acid in spinal deformity surgery.Authorship 12190413Authorship 12177856true1Instructor in NeurologyInstructor in NeurologyAuthorship 1225767732054143Koffie RM, Larsen AMG, Grannan BL, Hadzipasic M, Yanamadala V, Beaver LV, Shankar GM, Shin JHNeurospineNovel Technique for C1-2 Interlaminar Arthrodesis Utilizing a Modified Sonntag Loop-Suture Graft With Posterior C1-2 Fixation. Neurospine. 2020 Sep; 17(3):659-665.Neurospine2020-02-02T00:00:002020Novel Technique for C1-2 Interlaminar Arthrodesis Utilizing a Modified Sonntag Loop-Suture Graft With Posterior C1-2 Fixation.32252163Massaad E, Fatima N, Kiapour A, Hadzipasic M, Shankar GM, Shin JHNeurospinePolyetheretherketone Versus Titanium Cages for Posterior Lumbar Interbody Fusion: Meta-Analysis and Review of the Literature. Neurospine. 2020 Mar; 17(1):125-135.Neurospine2020-03-31T00:00:002020Polyetheretherketone Versus Titanium Cages for Posterior Lumbar Interbody Fusion: Meta-Analysis and Review of the Literature.Authorship 1237907532344139Fatima N, Zheng H, Massaad E, Hadzipasic M, Shankar GM, Shin JHWorld neurosurgeryDevelopment and Validation of Machine Learning Algorithms for Predicting Adverse Events After Surgery for Lumbar Degenerative Spondylolisthesis. World Neurosurg. 2020 08; 140:627-641.World Neurosurg2020-04-25T00:00:002020Development and Validation of Machine Learning Algorithms for Predicting Adverse Events After Surgery for Lumbar Degenerative Spondylolisthesis.Authorship 1243511532434032Fatima N, Massaad E, Alvarez-Breckenridge C, Berry Candelario JE, Hadzipasic M, Shankar GM, Shin JHWorld neurosurgeryDoes Obesity Correlate with Postoperative Complications After Elective Posterior Cervical Spine Fusion? World Neurosurg. 2020 09; 141:e231-e238.World Neurosurg2020-05-17T00:00:002020Does Obesity Correlate with Postoperative Complications After Elective Posterior Cervical Spine Fusion?Authorship 12472986true1Associate Professor of NeurosurgeryAssociate Professor of Neurosurgery32521012Shankar GM, Van Beaver LA, Choi BD, Hadzipasic M, Sivaganesan A, Karhade AV, Ferrone ML, Harris MB, Schoenfeld AJ, Sadow PM, Oh K, Schwab JH, Saylor PJ, Shin JHNeurosurgerySurvival After Surgery for Renal Cell Carcinoma Metastatic to the Spine: Impact of Modern Systemic Therapies on Outcomes. Neurosurgery. 2020 11 16; 87(6):1174-1180.Neurosurgery2020-11-16T00:00:002020Survival After Surgery for Renal Cell Carcinoma Metastatic to the Spine: Impact of Modern Systemic Therapies on Outcomes.Authorship 12556191Authorship 1262438532615704Massaad E, Fatima N, Kiapour A, Hadzipasic M, Shankar GM, Shin JHNeurospinePolyetheretherketone Versus Titanium Cages for Posterior Lumbar Interbody Fusion: Meta-Analysis and Review of the Literature. Neurospine. 2020 Jun; 17(2):473.Neurospine2020-06-30T00:00:002020Polyetheretherketone Versus Titanium Cages for Posterior Lumbar Interbody Fusion: Meta-Analysis and Review of the Literature.32728969Fatima N, Massaad E, Hadzipasic M, Shankar GM, Shin JHNeurosurgical reviewAssessment of the efficacy of teriparatide treatment for osteoporosis on lumbar fusion surgery outcomes: a systematic review and meta-analysis. Neurosurg Rev. 2021 Jun; 44(3):1357-1370.Neurosurg Rev2020-07-30T00:00:002020Assessment of the efficacy of teriparatide treatment for osteoporosis on lumbar fusion surgery outcomes: a systematic review and meta-analysis.Authorship 12709404Authorship 12894834Authorship 1289808232970147Massaad E, Shankar GM, Shin JHNeurosurgeryCommentary: Survival Trends After Surgery for Spinal Metastatic Tumors: 20-Year Cancer Center Experience. Neurosurgery. 2021 01 13; 88(2):E140-E141.Neurosurgery2021-01-13T00:00:002021Commentary: Survival Trends After Surgery for Spinal Metastatic Tumors: 20-Year Cancer Center Experience.32976997Fatima N, Massaad E, Hadzipasic M, Shankar GM, Shin JHThe spine journal : official journal of the North American Spine SocietySafety and accuracy of robot-assisted placement of pedicle screws compared to conventional free-hand technique: a systematic review and meta-analysis. Spine J. 2021 02; 21(2):181-192.Spine J2020-09-22T00:00:002020Safety and accuracy of robot-assisted placement of pedicle screws compared to conventional free-hand technique: a systematic review and meta-analysis.Authorship 12953781333051308Muralidharan K, Yekula A, Small JL, Rosh ZS, Kang KM, Wang L, Lau S, Zhang H, Lee H, Bettegowda C, Chicoine MR, Kalkanis SN, Shankar GM, Nahed BV, Curry WT, Jones PS, Cahill DP, Balaj L, Carter BSClinical cancer research : an official journal of the American Association for Cancer ResearchTERT Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas. Clin Cancer Res. 2021 01 01; 27(1):169-178.Clin Cancer Res2020-10-13T00:00:002020TERT Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas.Authorship 1308136233269385Massaad E, Shankar GM, Shin JHOperative neurosurgery (Hagerstown, Md.)Commentary: Use of Navigated Ultrasonic Bone Cutting Tool for En Bloc Resection of Thoracic Chondrosarcoma: Technical Report. Oper Neurosurg (Hagerstown). 2021 01 13; 20(2):E163-E164.Oper Neurosurg (Hagerstown)2021-01-13T00:00:002021Commentary: Use of Navigated Ultrasonic Bone Cutting Tool for En Bloc Resection of Thoracic Chondrosarcoma: Technical Report.33735913Gupta M, Burns EJ, Georgantas NZ, Thierauf J, Nayyar N, Gordon A, Jones SS, Pisapia M, Sun Y, Burns RP, Velarde J, Jordan JT, Frigault MJ, Nahed BV, Jones PS, Barker FG, Curry WT, Gupta R, Batchelor TT, Romero JM, Brastianos PK, Marble HD, Martinez-Lage M, Tateishi K, Lennerz JK, Dietrich J, Cahill DP, Carter BS, Shankar GMBloodA rapid genotyping panel for detection of primary central nervous system lymphoma. Blood. 2021 08 05; 138(5):382-386.Blood2021-08-05T00:00:002021A rapid genotyping panel for detection of primary central nervous system lymphoma.Authorship 1356426534015894Massaad E, Hadzipasic M, Kiapour A, Lak AM, Shankar G, Zaidi HA, Hershman SH, Shin JHNeurospineAssociation of Spinal Alignment Correction With Patient-Reported Outcomes in Adult Cervical Deformity: Review of the Literature. Neurospine. 2021 Sep; 18(3):533-542.Neurospine2021-05-18T00:00:002021Association of Spinal Alignment Correction With Patient-Reported Outcomes in Adult Cervical Deformity: Review of the Literature.Authorship 1364257234128068Massaad E, Shankar GM, Shin JHOperative neurosurgery (Hagerstown, Md.)Novel Applications of Spinal Navigation in Deformity and Oncology Surgery-Beyond Screw Placement. Oper Neurosurg (Hagerstown). 2021 06 15; 21(Supp 1):S23-S38.Oper Neurosurg (Hagerstown)2021-06-15T00:00:002021Novel Applications of Spinal Navigation in Deformity and Oncology Surgery-Beyond Screw Placement.Authorship 139170429EAM71ElieMassaadElie Massaad, M.D.180411Massaad, ElieResearch Fellow in NeurosurgeryAuthorship 14145233Authorship 1410447434862557Massaad E, Ha Y, Shankar GM, Shin JHActa neurochirurgica. SupplementClinical Prediction Modeling in Intramedullary Spinal Tumor Surgery. Acta Neurochir Suppl. 2022; 134:333-339.Acta Neurochir Suppl2022-01-01T00:00:002022Clinical Prediction Modeling in Intramedullary Spinal Tumor Surgery.34775511Fatima N, Massaad E, Hadzipasic M, Shankar GM, Shin JHNeurosurgical reviewCorrection to: Assessment of the efficacy of teriparatide treatment for osteoporosis on lumbar fusion surgery outcomes: a systematic review and meta-analysis. Neurosurg Rev. 2022 Apr; 45(2):1817-1818.Neurosurg Rev2022-04-01T00:00:002022Correction to: Assessment of the efficacy of teriparatide treatment for osteoporosis on lumbar fusion surgery outcomes: a systematic review and meta-analysis.Authorship 1421087534952510Kiapour A, Massaad E, Joukar A, Hadzipasic M, Shankar GM, Goel VK, Shin JHJournal of neurosurgery. SpineBiomechanical analysis of stand-alone lumbar interbody cages versus 360° constructs: an in vitro and finite element investigation. J Neurosurg Spine. 2022 Jun 01; 36(6):928-936.J Neurosurg Spine2021-12-24T00:00:002021Biomechanical analysis of stand-alone lumbar interbody cages versus 360° constructs: an in vitro and finite element investigation.Authorship 1421929334995270Massaad E, Duvall JB, Shankar GM, Shin JHNeurosurgeryCommentary: Hybrid Therapy (Surgery and Radiosurgery) for the Treatment of Renal Cell Carcinoma Spinal Metastases. Neurosurgery. 2022 02 01; 90(2):e35-e36.Neurosurgery2022-02-01T00:00:002022Commentary: Hybrid Therapy (Surgery and Radiosurgery) for the Treatment of Renal Cell Carcinoma Spinal Metastases.Authorship 1431864635107085Karandikar P, Massaad E, Hadzipasic M, Kiapour A, Joshi RS, Shankar GM, Shin JHNeurosurgeryMachine Learning Applications of Surgical Imaging for the Diagnosis and Treatment of Spine Disorders: Current State of the Art. Neurosurgery. 2022 04 01; 90(4):372-382.Neurosurgery2022-04-01T00:00:002022Machine Learning Applications of Surgical Imaging for the Diagnosis and Treatment of Spine Disorders: Current State of the Art.true1Professor of NeurosurgeryProfessor of NeurosurgeryAuthorship 1438088835213829Massaad E, Bridge CP, Kiapour A, Fourman MS, Duvall JB, Connolly ID, Hadzipasic M, Shankar GM, Andriole KP, Rosenthal M, Schoenfeld AJ, Bilsky MH, Shin JHJournal of neurosurgery. SpineEvaluating frailty, mortality, and complications associated with metastatic spine tumor surgery using machine learning-derived body composition analysis. J Neurosurg Spine. 2022 Feb 25; 1-11.J Neurosurg Spine2022-02-25T00:00:002022Evaluating frailty, mortality, and complications associated with metastatic spine tumor surgery using machine learning-derived body composition analysis.35852437Dias-Santagata D, Heist RS, Bard AZ, da Silva AFL, Dagogo-Jack I, Nardi V, Ritterhouse LL, Spring LM, Jessop N, Farahani AA, Mino-Kenudson M, Allen J, Goyal L, Parikh A, Misdraji J, Shankar G, Jordan JT, Martinez-Lage M, Frosch M, Graubert T, Fathi AT, Hobbs GS, Hasserjian RP, Raje N, Abramson J, Schwartz JH, Sullivan RJ, Miller D, Hoang MP, Isakoff S, Ly A, Bouberhan S, Watkins J, Oliva E, Wirth L, Sadow PM, Faquin W, Cote GM, Hung YP, Gao X, Wu CL, Garg S, Rivera M, Le LP, John Iafrate A, Juric D, Hochberg EP, Clark J, Bardia A, Lennerz JKThe oncologistImplementation and Clinical Adoption of Precision Oncology Workflows Across a Healthcare Network. Oncologist. 2022 11 03; 27(11):930-939.Oncologist2022-11-03T00:00:002022Implementation and Clinical Adoption of Precision Oncology Workflows Across a Healthcare Network.Authorship 14632696Authorship 14632291635901764Kiapour A, Khandha A, Massaad E, Connolly ID, Hadzipasic M, Shankar GM, Goel V, Shin JHJournal of neurosurgery. SpineEffects of rod diameter on kinematics of posterior cervical spine instrumented constructs: an ex vivo study. J Neurosurg Spine. 2022 Jun 10; 1-9.J Neurosurg Spine2022-06-10T00:00:002022Effects of rod diameter on kinematics of posterior cervical spine instrumented constructs: an ex vivo study.Authorship 14807582Authorship 1491736935957652Lester EG, Shankar GJournal of patient experienceA Clinical Psychologist's Reflections on the Process of Electing for Neurosurgery. J Patient Exp. 2022; 9:23743735221119023.J Patient Exp2022-08-02T00:00:002022A Clinical Psychologist's Reflections on the Process of Electing for Neurosurgery.36305664Duvall JB, Massaad E, Siraj L, Kiapour A, Connolly I, Hadzipasic M, Elsamadicy AA, Williamson T, Shankar GM, Schoenfeld AJ, Fourman MS, Shin JHNeurosurgeryAssessment of Spinal Metastases Surgery Risk Stratification Tools in Breast Cancer by Molecular Subtype. Neurosurgery. 2023 01 01; 92(1):83-91.Neurosurgery2022-10-28T00:00:002022Assessment of Spinal Metastases Surgery Risk Stratification Tools in Breast Cancer by Molecular Subtype.true1Professor of Orthopedic SurgeryProfessor of Orthopedic SurgeryAuthorship 15245089Authorship 1524498736805503Fourman MS, Siraj L, Duvall J, Ramsey DC, De La Garza Ramos R, Hadzipasic M, Connolly I, Williamson T, Shankar GM, Schoenfeld A, Yassari R, Massaad E, Shin JHWorld neurosurgeryCan We Use Artificial Intelligence Cluster Analysis to Identify Patients with Metastatic Breast Cancer to the Spine at Highest Risk of Postoperative Adverse Events? World Neurosurg. 2023 Jun; 174:e26-e34.World Neurosurg2023-02-18T00:00:002023Can We Use Artificial Intelligence Cluster Analysis to Identify Patients with Metastatic Breast Cancer to the Spine at Highest Risk of Postoperative Adverse Events?36805433Gritsch S, Aghajan Y, Kozanno L, Chiu D, Jordan JT, Frosch MP, Shankar G, Kimberly WTNeurologyTeaching NeuroImage: Subacute Quadriparesis From Intramedullary Spinal Cord Infiltrating Glioma With TERT Promoter Mutation. Neurology. 2023 06 13; 100(24):1164-1165.Neurology2023-02-20T00:00:002023Teaching NeuroImage: Subacute Quadriparesis From Intramedullary Spinal Cord Infiltrating Glioma With TERT Promoter Mutation.Authorship 15678141737402650Karschnia P, Arrillaga-Romany IC, Eichler A, Forst DA, Gerstner E, Jordan JT, Ly I, Plotkin SR, Wang N, Martinez-Lage M, Winter SF, Tonn JC, Rejeski K, von Baumgarten L, Cahill DP, Nahed BV, Shankar GM, Abramson JS, Barnes JA, El-Jawahri A, Hochberg EP, Johnson PC, Soumerai JD, Takvorian RW, Chen YB, Frigault MJ, Dietrich JNeuro-oncologyNeurotoxicity and management of primary and secondary central nervous system lymphoma after adoptive immunotherapy with CD19-directed chimeric antigen receptor T-cells. Neuro Oncol. 2023 12 08; 25(12):2239-2249.Neuro Oncol2023-12-08T00:00:002023Neurotoxicity and management of primary and secondary central nervous system lymphoma after adoptive immunotherapy with CD19-directed chimeric antigen receptor T-cells.Authorship 15941481237795983Ng PR, Yearley AG, Eatz TA, Ajmera S, West T, Razak SS, Lazaro T, Urakov T, Jones PS, Coumans JV, Stapleton CJ, Shankar G, Chen HI, Komotar RJ, Patel AJ, Nahed BVNeurosurgeryNeurological Surgery Residency Programs in the United States: A National Cross-Sectional Survey. Neurosurgery. 2024 Mar 01; 94(3):529-537.Neurosurgery2023-10-05T00:00:002023Neurological Surgery Residency Programs in the United States: A National Cross-Sectional Survey.true1Gregor Mendel Professor of Genetics and of MedicineGregor Mendel Professor of Genetics and of MedicineAuthorship 4638642Authorship 1618444638169188Hadzipasic M, Zhang S, Huang Z, Passaro R, Sten MS, Shankar GM, Nia HTBiomaterialsEmergence of nanoscale viscoelasticity from single cancer cells to established tumors. Biomaterials. 2024 Mar; 305:122431.Biomaterials2023-12-22T00:00:002023Emergence of nanoscale viscoelasticity from single cancer cells to established tumors.true1Research Fellow in NeurosurgeryResearch Fellow in Neurosurgerytrue1Robert H. Ebert Professor of MedicineRobert H. Ebert Professor of Medicinetrue1Assistant Professor of MedicineAssistant Professor of Medicinetrue1Associate Professor of NeurologyAssociate Professor of NeurologyAuthorship 5051117Authorship 5746474NeurosurgeryAuthorship 2250981Authorship 2905941Authorship 746343125144287Shankar GM, Barker FGOncology (Williston Park, N.Y.)Primary CNS lymphoma: the role of resection. Oncology (Williston Park). 2014 Jul; 28(7):637-8, 640, 642.Oncology (Williston Park)2014-07-01T00:00:002014Primary CNS lymphoma: the role of resection.Authorship 756193324840308Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJBiochemistrySecreted amyloid ß-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity. Biochemistry. 2014 Jun 24; 53(24):3908-21.Biochemistry2014-06-24T00:00:002014Secreted amyloid ß-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity.Authorship 228580125589003Shankar GM, Taylor-Weiner A, Lelic N, Jones RT, Kim JC, Francis JM, Abedalthagafi M, Borges LF, Coumans JV, Curry WT, Nahed BV, Shin JH, Paek SH, Park SH, Stewart C, Lawrence MS, Cibulskis K, Thorner AR, Van Hummelen P, Stemmer-Rachamimov AO, Batchelor TT, Carter SL, Hoang MP, Santagata S, Louis DN, Barker FG, Meyerson M, Getz G, Brastianos PK, Cahill DPActa neuropathologica communicationsSporadic hemangioblastomas are characterized by cryptic VHL inactivation. Acta Neuropathol Commun. 2014 Dec 24; 2:167.Acta Neuropathol Commun2014-12-24T00:00:002014Sporadic hemangioblastomas are characterized by cryptic VHL inactivation.AJS44AndrewSchoenfeldAndrew J Schoenfeld, M.D.24373Schoenfeld, AndrewProfessor of Orthopedic SurgeryAuthorship 2577412Authorship 3931835Authorship 4462183Authorship 3188315Authorship 3566493Authorship 4876112Authorship 931583Authorship 2551152Authorship 3191074Authorship 3900183Authorship 4207791Authorship 8045241Authorship 803045325779946Eisele SC, Gill CM, Shankar GM, Brastianos PKClinical cancer research : an official journal of the American Association for Cancer ResearchPLEKHA5: A Key to Unlock the Blood-Brain Barrier? Clin Cancer Res. 2015 May 01; 21(9):1978-80.Clin Cancer Res2015-03-16T00:00:002015PLEKHA5: A Key to Unlock the Blood-Brain Barrier?Authorship 3083184Authorship 823713126181761Shankar GM, Francis JM, Rinne ML, Ramkissoon SH, Huang FW, Venteicher AS, Akama-Garren EH, Kang YJ, Lelic N, Kim JC, Brown LE, Charbonneau SK, Golby AJ, Sekhar Pedamallu C, Hoang MP, Sullivan RJ, Cherniack AD, Garraway LA, Stemmer-Rachamimov A, Reardon DA, Wen PY, Brastianos PK, Curry WT, Barker FG, Hahn WC, Nahed BV, Ligon KL, Louis DN, Cahill DP, Meyerson MJAMA oncologyRapid Intraoperative Molecular Characterization of Glioma. JAMA Oncol. 2015 Aug; 1(5):662-7.JAMA Oncol2015-08-01T00:00:002015Rapid Intraoperative Molecular Characterization of Glioma.26498373Brastianos PK, Shankar GM, Gill CM, Taylor-Weiner A, Nayyar N, Panka DJ, Sullivan RJ, Frederick DT, Abedalthagafi M, Jones PS, Dunn IF, Nahed BV, Romero JM, Louis DN, Getz G, Cahill DP, Santagata S, Curry WT, Barker FGJournal of the National Cancer InstituteDramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy. J Natl Cancer Inst. 2016 Feb; 108(2).J Natl Cancer Inst2015-10-23T00:00:002015Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy.Authorship 8428752Authorship 8746133Authorship 874530326765762Lee D, Yanamadala V, Shankar GM, Shin JHJournal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaMetastatic adrenal cortical carcinoma to T12 vertebrae. J Clin Neurosci. 2016 May; 27:166-9.J Clin Neurosci2016-01-04T00:00:002016Metastatic adrenal cortical carcinoma to T12 vertebrae.26755453Yanamadala V, Koffie RM, Shankar GM, Kumar JI, Buchlak QD, Puthenpura V, Frosch MP, Gudewicz TM, Borges LF, Shin JHJournal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaSpinal cord glioblastoma: 25years of experience from a single institution. J Clin Neurosci. 2016 May; 27:138-41.J Clin Neurosci2016-01-02T00:00:002016Spinal cord glioblastoma: 25years of experience from a single institution.Authorship 5216101Authorship 56381312Assistant Professor1Associate Professor0Full Professor4Instructor3Lecturer5Other FacultyAuthorship 4776675Authorship 922746427403775Friedman GN, Grannan BL, Yanamadala V, Shankar GM, Dewitt JC, Puthenpura V, Koffie RM, Macdonald SM, Ebb DH, Frosch MP, Duhaime ACJournal of pediatric hematology/oncologyRapid Neurological Recovery Following Partial Surgical Resection of Spinal Glioblastoma Multiforme in a Pediatric Patient Presenting With Complete Paraplegia. J Pediatr Hematol Oncol. 2016 11; 38(8):e286-e290.J Pediatr Hematol Oncol2016-11-01T00:00:002016Rapid Neurological Recovery Following Partial Surgical Resection of Spinal Glioblastoma Multiforme in a Pediatric Patient Presenting With Complete Paraplegia.Authorship 933821127879568Shankar GM, Choi BD, Grannan BL, Oh K, Shin JHSpineEffect of Immunotherapy Status on Outcomes in Patients With Metastatic Melanoma to the Spine. Spine (Phila Pa 1976). 2017 Jun 15; 42(12):E721-E725.Spine (Phila Pa 1976)2017-06-15T00:00:002017Effect of Immunotherapy Status on Outcomes in Patients With Metastatic Melanoma to the Spine.Authorship 4244173Authorship 956818128170043Shankar GM, Abedalthagafi M, Vaubel RA, Merrill PH, Nayyar N, Gill CM, Brewster R, Bi WL, Agarwalla PK, Thorner AR, Reardon DA, Al-Mefty O, Wen PY, Alexander BM, van Hummelen P, Batchelor TT, Ligon KL, Ligon AH, Meyerson M, Dunn IF, Beroukhim R, Louis DN, Perry A, Carter SL, Giannini C, Curry WT, Cahill DP, Barker FG, Brastianos PK, Santagata SNeuro-oncologyGermline and somatic BAP1 mutations in high-grade rhabdoid meningiomas. Neuro Oncol. 2017 04 01; 19(4):535-545.Neuro Oncol2017-04-01T00:00:002017Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas.19455250Lo KC, Shankar G, Turpaz Y, Bailey D, Rossi MR, Burkhardt T, Liang P, Cowell JKCancer informaticsOverlay tool for aCGHViewer: an analysis module built for aCGHViewer used to perform comparisons of data derived from different microarray platforms. Cancer Inform. 2007 Aug 08; 3:307-19.Cancer Inform2007-08-08T00:00:002007Overlay tool for aCGHViewer: an analysis module built for aCGHViewer used to perform comparisons of data derived from different microarray platforms.15834427Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJNature medicineAmyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med. 2005 May; 11(5):556-61.Nat Med2005-04-17T00:00:002005Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.15608634Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KHNature neuroscienceNatural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat Neurosci. 2005 Jan; 8(1):79-84.Nat Neurosci2004-12-19T00:00:002004Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function.Authorship 982158128482042Shankar GM, Santagata SNeuro-oncologyBAP1 mutations in high-grade meningioma: implications for patient care. Neuro Oncol. 2017 Oct 19; 19(11):1447-1456.Neuro Oncol2017-10-19T00:00:002017BAP1 mutations in high-grade meningioma: implications for patient care.18024968Shen C, Wang Z, Shankar G, Zhang X, Li LBioinformatics (Oxford, England)A hierarchical statistical model to assess the confidence of peptides and proteins inferred from tandem mass spectrometry. Bioinformatics. 2008 Jan 15; 24(2):202-8.Bioinformatics2007-11-17T00:00:002007A hierarchical statistical model to assess the confidence of peptides and proteins inferred from tandem mass spectrometry.17591969Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJThe American journal of pathologyLoss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. Am J Pathol. 2007 Jul; 171(1):241-51.Am J Pathol2007-07-01T00:00:002007Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy.28625978Tateishi K, Higuchi F, Miller JJ, Koerner MVA, Lelic N, Shankar GM, Tanaka S, Fisher DE, Batchelor TT, Iafrate AJ, Wakimoto H, Chi AS, Cahill DPCancer researchThe Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in IDH1-Mutant Cancers and Potentiates NAD+ Depletion-Mediated Cytotoxicity. Cancer Res. 2017 08 01; 77(15):4102-4115.Cancer Res2017-06-16T00:00:002017The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in IDH1-Mutant Cancers and Potentiates NAD+ Depletion-Mediated Cytotoxicity.19555648Li S, Hong S, Shepardson NE, Walsh DM, Shankar GM, Selkoe DNeuronSoluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron. 2009 Jun 25; 62(6):788-801.Neuron2009-06-25T00:00:002009Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake.19204155Xia W, Yang T, Shankar G, Smith IM, Shen Y, Walsh DM, Selkoe DJArchives of neurologyA specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease. Arch Neurol. 2009 Feb; 66(2):190-9.Arch Neurol2009-02-01T00:00:002009A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease.28452631Shankar GM, Clarke MJ, Ailon T, Rhines LD, Patel SR, Sahgal A, Laufer I, Chou D, Bilsky MH, Sciubba DM, Fehlings MG, Fisher CG, Gokaslan ZL, Shin JHJournal of neurosurgery. SpineThe role of revision surgery and adjuvant therapy following subtotal resection of osteosarcoma of the spine: a systematic review with meta-analysis. J Neurosurg Spine. 2017 Jul; 27(1):97-104.J Neurosurg Spine2017-04-28T00:00:002017The role of revision surgery and adjuvant therapy following subtotal resection of osteosarcoma of the spine: a systematic review with meta-analysis.15758153Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, El Agnaf O, Hartley DM, Selkoe DJThe Journal of neuroscience : the official journal of the Society for NeuroscienceCertain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation. J Neurosci. 2005 Mar 09; 25(10):2455-62.J Neurosci2005-03-09T00:00:002005Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.16246051Walsh DM, Klyubin I, Shankar GM, Townsend M, Fadeeva JV, Betts V, Podlisny MB, Cleary JP, Ashe KH, Rowan MJ, Selkoe DJBiochemical Society transactionsThe role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention. Biochem Soc Trans. 2005 Nov; 33(Pt 5):1087-90.Biochem Soc Trans2005-11-01T00:00:002005The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention.23144305Diamond EL, Kimchi EY, Shankar GM, Silverman SBPractical neurologyTransient aqueductal occlusion in intracerebral haemorrhage. Pract Neurol. 2012 Dec; 12(6):388-9.Pract Neurol2012-12-01T00:00:002012Transient aqueductal occlusion in intracerebral haemorrhage.17404607Shankar G, Rossi MR, McQuaid DE, Conroy JM, Gaile DG, Cowell JK, Nowak NJ, Liang PCancer informaticsaCGHViewer: a generic visualization tool for aCGH data. Cancer Inform. 2006; 2:36-43.Cancer Inform2006-01-01T00:00:002006aCGHViewer: a generic visualization tool for aCGH data.19930651Shankar GM, Walsh DMMolecular neurodegenerationAlzheimer's disease: synaptic dysfunction and Abeta. Mol Neurodegener. 2009 Nov 23; 4:48.Mol Neurodegener2009-11-23T00:00:002009Alzheimer's disease: synaptic dysfunction and Abeta.Authorship 9998236Authorship 9996701Authorship 1009164128875730Shankar GM, Balaj L, Stott SL, Nahed B, Carter BSExpert review of molecular diagnosticsLiquid biopsy for brain tumors. Expert Rev Mol Diagn. 2017 10; 17(10):943-947.Expert Rev Mol Diagn2017-09-06T00:00:002017Liquid biopsy for brain tumors.55 Fruit StMassachusetts General HospitalSurgery - WH 50255 Fruit StBoston02114MA16469784Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJThe Journal of physiologyEffects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. J Physiol. 2006 Apr 15; 572(Pt 2):477-92.J Physiol2006-02-09T00:00:002006Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.21543591Li S, Jin M, Koeglsperger T, Shepardson NE, Shankar GM, Selkoe DJThe Journal of neuroscience : the official journal of the Society for NeuroscienceSoluble Aß oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. J Neurosci. 2011 May 04; 31(18):6627-38.J Neurosci2011-05-04T00:00:002011Soluble Aß oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors.22438044Fu H, Liu B, Frost JL, Hong S, Jin M, Ostaszewski B, Shankar GM, Costantino IM, Carroll MC, Mayadas TN, Lemere CAGliaComplement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aß by microglia. Glia. 2012 May; 60(6):993-1003.Glia2012-03-21T00:00:002012Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aß by microglia.22084122Shepardson NE, Shankar GM, Selkoe DJArchives of neurologyCholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations. Arch Neurol. 2011 Nov; 68(11):1385-92.Arch Neurol2011-11-01T00:00:002011Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations.Authorship 1037701629312603Juratli TA, Thiede C, Koerner MVA, Tummala SS, Daubner D, Shankar GM, Williams EA, Martinez-Lage M, Soucek S, Robel K, Penson T, Krause M, Appold S, Meinhardt M, Pinzer T, Miller JJ, Krex D, Ely HA, Silverman IM, Christiansen J, Schackert G, Wakimoto H, Kirsch M, Brastianos PK, Cahill DPOncotargetIntratumoral heterogeneity and TERT promoter mutations in progressive/higher-grade meningiomas. Oncotarget. 2017 Dec 12; 8(65):109228-109237.Oncotarget2017-11-24T00:00:002017Intratumoral heterogeneity and TERT promoter mutations in progressive/higher-grade meningiomas.