Kirchhausen, Tomas
completed student projects: Secramine: Specificity and Inhibition of Cell Transformation
eCommons Login: TK16
first name: Tomas
last name: Kirchhausen
coauthor of: Sanyal, Anwesha
coauthor of: Harrison, Stephen
coauthor of: Hatzakis, Nikos
coauthor of: Saminathan, Anand
coauthor of: Rapoport, Iris
full name: Tomas Leopold Kirchhausen, Ph.D.
has faculty rank: Full Professor
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latitude: 42.33594500000000
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Person ID: 18590
person in primary position: Professor of Cell Biology
physical neighbor: Carroll, Elisabeth
physical neighbor: Carroll, Michael
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physical neighbor: Rapoport, Iris
physical neighbor: Rudner, David
similar to: Harrison, Stephen
similar to: Rapoport, Tom
similar to: Hsu, Victor
similar to: Gygi, Steven
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selected publications: Authorship 1834940
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selected publications: Authorship 1057778
selected publications: Authorship 1089462

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Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2.
PubMed Identifier: 10438921
author list: Schneider H, Martin M, Agarraberes FA, Yin L, Rapoport I, Kirchhausen T, Rudd CE
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2. J Immunol. 1999 Aug 15; 163(4):1868-79.
journal title abbreviation: J Immunol
publication date: 1999-08-15T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin.
PubMed Identifier: 10655490
author list: ter Haar E, Harrison SC, Kirchhausen T
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin. Proc Natl Acad Sci U S A. 2000 Feb 01; 97(3):1096-100.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2000-02-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Three ways to make a vesicle.
PubMed Identifier: 11252894
author list: Kirchhausen T
published in: Nature reviews. Molecular cell biology
information resource reference: Three ways to make a vesicle. Nat Rev Mol Cell Biol. 2000 Dec; 1(3):187-98.
journal title abbreviation: Nat Rev Mol Cell Biol
publication date: 2000-12-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Arrangement of domains, and amino acid residues required for binding of vascular cell adhesion molecule-1 to its counter-receptor VLA-4 (alpha 4 beta 1).
PubMed Identifier: 7508942
author list: Osborn L, Vassallo C, Browning BG, Tizard R, Haskard DO, Benjamin CD, Dougas I, Kirchhausen T
published in: The Journal of cell biology
information resource reference: Arrangement of domains, and amino acid residues required for binding of vascular cell adhesion molecule-1 to its counter-receptor VLA-4 (alpha 4 beta 1). J Cell Biol. 1994 Feb; 124(4):601-8.
journal title abbreviation: J Cell Biol
publication date: 1994-02-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

A late Golgi sorting function for Saccharomyces cerevisiae Apm1p, but not for Apm2p, a second yeast clathrin AP medium chain-related protein.
PubMed Identifier: 7749194
author list: Stepp JD, Pellicena-Palle A, Hamilton S, Kirchhausen T, Lemmon SK
published in: Molecular biology of the cell
information resource reference: A late Golgi sorting function for Saccharomyces cerevisiae Apm1p, but not for Apm2p, a second yeast clathrin AP medium chain-related protein. Mol Biol Cell. 1995 Jan; 6(1):41-58.
journal title abbreviation: Mol Biol Cell
publication date: 1995-01-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1057778
type: Authorship
author rank in publication: 26
linked author: Kirchhausen, Tomas
linked information resource: Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms.

Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms.
PubMed Identifier: 29674564
author list: Liu TL, Upadhyayula S, Milkie DE, Singh V, Wang K, Swinburne IA, Mosaliganti KR, Collins ZM, Hiscock TW, Shea J, Kohrman AQ, Medwig TN, Dambournet D, Forster R, Cunniff B, Ruan Y, Yashiro H, Scholpp S, Meyerowitz EM, Hockemeyer D, Drubin DG, Martin BL, Matus DQ, Koyama M, Megason SG, Kirchhausen T, Betzig E
published in: Science (New York, N.Y.)
information resource reference: Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms. Science. 2018 04 20; 360(6386).
journal title abbreviation: Science
publication date: 2018-04-20T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly.
PubMed Identifier: 20033059
author list: Xing Y, Böcking T, Wolf M, Grigorieff N, Kirchhausen T, Harrison SC
published in: The EMBO journal
information resource reference: Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly. EMBO J. 2010 Feb 03; 29(3):655-65.
journal title abbreviation: EMBO J
publication date: 2009-12-24T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Shiga toxin increases formation of clathrin-coated pits through Syk kinase.
PubMed Identifier: 20668539
author list: Utskarpen A, Massol R, van Deurs B, Lauvrak SU, Kirchhausen T, Sandvig K
published in: PloS one
information resource reference: Shiga toxin increases formation of clathrin-coated pits through Syk kinase. PLoS One. 2010 Jul 27; 5(7):e10944.
journal title abbreviation: PLoS One
publication date: 2010-07-27T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42.
PubMed Identifier: 8643625
author list: Kolluri R, Tolias KF, Carpenter CL, Rosen FS, Kirchhausen T
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5615-8.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1996-05-28T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Making COPII coats.
PubMed Identifier: 17604713
author list: Kirchhausen T
published in: Cell
information resource reference: Making COPII coats. Cell. 2007 Jun 29; 129(7):1251-2.
journal title abbreviation: Cell
publication date: 2007-06-29T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of a putative yeast homolog of the mammalian beta chains of the clathrin-associated protein complexes.
PubMed Identifier: 2122239
author list: Kirchhausen T
published in: Molecular and cellular biology
information resource reference: Identification of a putative yeast homolog of the mammalian beta chains of the clathrin-associated protein complexes. Mol Cell Biol. 1990 Nov; 10(11):6089-90.
journal title abbreviation: Mol Cell Biol
publication date: 1990-11-01T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

An ACAP1-containing clathrin coat complex for endocytic recycling.
PubMed Identifier: 17664335
author list: Li J, Peters PJ, Bai M, Dai J, Bos E, Kirchhausen T, Kandror KV, Hsu VW
published in: The Journal of cell biology
information resource reference: An ACAP1-containing clathrin coat complex for endocytic recycling. J Cell Biol. 2007 Jul 30; 178(3):453-64.
journal title abbreviation: J Cell Biol
publication date: 2007-07-30T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity.
PubMed Identifier: 18067275
author list: Nieland TJ, Shaw JT, Jaipuri FA, Duffner JL, Koehler AN, Banakos S, Zannis VI, Kirchhausen T, Krieger M
published in: Biochemistry
information resource reference: Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity. Biochemistry. 2008 Jan 08; 47(1):460-72.
journal title abbreviation: Biochemistry
publication date: 2007-12-08T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Roles of AP-2 in clathrin-mediated endocytosis.
PubMed Identifier: 20485680
author list: Boucrot E, Saffarian S, Zhang R, Kirchhausen T
published in: PloS one
information resource reference: Roles of AP-2 in clathrin-mediated endocytosis. PLoS One. 2010 May 12; 5(5):e10597.
journal title abbreviation: PLoS One
publication date: 2010-05-12T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

ARFGAP1 promotes AP-2-dependent endocytosis.
PubMed Identifier: 21499258
author list: Bai M, Gad H, Turacchio G, Cocucci E, Yang JS, Li J, Beznoussenko GV, Nie Z, Luo R, Fu L, Collawn JF, Kirchhausen T, Luini A, Hsu VW
published in: Nature cell biology
information resource reference: ARFGAP1 promotes AP-2-dependent endocytosis. Nat Cell Biol. 2011 May; 13(5):559-67.
journal title abbreviation: Nat Cell Biol
publication date: 2011-04-17T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.
PubMed Identifier: 21685908
author list: Thiery J, Keefe D, Boulant S, Boucrot E, Walch M, Martinvalet D, Goping IS, Bleackley RC, Kirchhausen T, Lieberman J
published in: Nature immunology
information resource reference: Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nat Immunol. 2011 Jun 19; 12(8):770-7.
journal title abbreviation: Nat Immunol
publication date: 2011-06-19T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Cholera toxin toxicity does not require functional Arf6- and dynamin-dependent endocytic pathways.
PubMed Identifier: 15146065
author list: Massol RH, Larsen JE, Fujinaga Y, Lencer WI, Kirchhausen T
published in: Molecular biology of the cell
information resource reference: Cholera toxin toxicity does not require functional Arf6- and dynamin-dependent endocytic pathways. Mol Biol Cell. 2004 Aug; 15(8):3631-41.
journal title abbreviation: Mol Biol Cell
publication date: 2004-05-14T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Clathrin domains involved in recognition by assembly protein AP-2.
PubMed Identifier: 1902233
author list: Keen JH, Beck KA, Kirchhausen T, Jarrett T
published in: The Journal of biological chemistry
information resource reference: Clathrin domains involved in recognition by assembly protein AP-2. J Biol Chem. 1991 Apr 25; 266(12):7950-6.
journal title abbreviation: J Biol Chem
publication date: 1991-04-25T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Effects of dynamin inactivation on pathways of anthrax toxin uptake.
PubMed Identifier: 15511085
author list: Boll W, Ehrlich M, Collier RJ, Kirchhausen T
published in: European journal of cell biology
information resource reference: Effects of dynamin inactivation on pathways of anthrax toxin uptake. Eur J Cell Biol. 2004 Jul; 83(6):281-8.
journal title abbreviation: Eur J Cell Biol
publication date: 2004-07-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis.
PubMed Identifier: 17093049
author list: Newton AJ, Kirchhausen T, Murthy VN
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17955-60.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2006-11-08T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Single-handed recognition of a sorting traffic motif by the GGA proteins.
PubMed Identifier: 11914729
author list: Kirchhausen T
published in: Nature structural biology
information resource reference: Single-handed recognition of a sorting traffic motif by the GGA proteins. Nat Struct Biol. 2002 Apr; 9(4):241-4.
journal title abbreviation: Nat Struct Biol
publication date: 2002-04-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure.
PubMed Identifier: 29916365
author list: Swinburne IA, Mosaliganti KR, Upadhyayula S, Liu TL, Hildebrand DGC, Tsai TY, Chen A, Al-Obeidi E, Fass AK, Malhotra S, Engert F, Lichtman JW, Kirchhausen T, Betzig E, Megason SG
published in: eLife
information resource reference: Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure. Elife. 2018 06 19; 7.
journal title abbreviation: Elife
publication date: 2018-06-19T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi.
PubMed Identifier: 12914695
author list: Wang YJ, Wang J, Sun HQ, Martinez M, Sun YX, Macia E, Kirchhausen T, Albanesi JP, Roth MG, Yin HL
published in: Cell
information resource reference: Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi. Cell. 2003 Aug 08; 114(3):299-310.
journal title abbreviation: Cell
publication date: 2003-08-08T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Thermal effects in human plasma high density lipoproteins (HDL)3: a 13C-FT-NMR study.
PubMed Identifier: 6544544
author list: León V, Kirchhausen T, Avila EM, Mateu L
published in: Acta cientifica venezolana
information resource reference: Thermal effects in human plasma high density lipoproteins (HDL)3: a 13C-FT-NMR study. Acta Cient Venez. 1983; 34(3-4):209-15.
journal title abbreviation: Acta Cient Venez
publication date: 1983-01-01T00:00:00
year: 1983
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 119308
type: Authorship
author rank in publication: 4
linked author: Kirchhausen, Tomas
linked information resource: A late Golgi sorting function for Saccharomyces cerevisiae Apm1p, but not for Apm2p, a second yeast clathrin AP medium chain-related protein.

Visualizing the high curvature regions of post-mitotic nascent nuclear envelope membrane.
PubMed Identifier: 22482003
author list: Lu L, Kirchhausen T
published in: Communicative & integrative biology
information resource reference: Visualizing the high curvature regions of post-mitotic nascent nuclear envelope membrane. Commun Integr Biol. 2012 Jan 01; 5(1):16-8.
journal title abbreviation: Commun Integr Biol
publication date: 2012-01-01T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells.
PubMed Identifier: 15153932
author list: Feng Y, Jadhav AP, Rodighiero C, Fujinaga Y, Kirchhausen T, Lencer WI
published in: EMBO reports
information resource reference: Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells. EMBO Rep. 2004 Jun; 5(6):596-601.
journal title abbreviation: EMBO Rep
publication date: 2004-05-21T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 10623
type: Authorship
author rank in publication: 5
linked author: Kirchhausen, Tomas
linked information resource: Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits.

A motif in the clathrin heavy chain required for the Hsc70/auxilin uncoating reaction.
PubMed Identifier: 17978091
author list: Rapoport I, Boll W, Yu A, Böcking T, Kirchhausen T
published in: Molecular biology of the cell
information resource reference: A motif in the clathrin heavy chain required for the Hsc70/auxilin uncoating reaction. Mol Biol Cell. 2008 Jan; 19(1):405-13.
journal title abbreviation: Mol Biol Cell
publication date: 2007-10-31T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis.
PubMed Identifier: 22156516
author list: Strang BL, Boulant S, Chang L, Knipe DM, Kirchhausen T, Coen DM
published in: Journal of virology
information resource reference: Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis. J Virol. 2012 Feb; 86(4):2089-95.
journal title abbreviation: J Virol
publication date: 2011-12-07T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating.
PubMed Identifier: 16798879
author list: Massol RH, Boll W, Griffin AM, Kirchhausen T
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10265-10270.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2006-06-23T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Analysis of clathrin light chain-heavy chain interactions using truncated mutants of rat liver light chain LCB3.
PubMed Identifier: 2406259
author list: Scarmato P, Kirchhausen T
published in: The Journal of biological chemistry
information resource reference: Analysis of clathrin light chain-heavy chain interactions using truncated mutants of rat liver light chain LCB3. J Biol Chem. 1990 Mar 05; 265(7):3661-8.
journal title abbreviation: J Biol Chem
publication date: 1990-03-05T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1083741
type: Authorship
author rank in publication: 21
linked author: Kirchhausen, Tomas
linked information resource: The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles.

The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles.
PubMed Identifier: 30044992
author list: Coulter ME, Dorobantu CM, Lodewijk GA, Delalande F, Cianferani S, Ganesh VS, Smith RS, Lim ET, Xu CS, Pang S, Wong ET, Lidov HGW, Calicchio ML, Yang E, Gonzalez DM, Schlaeger TM, Mochida GH, Hess H, Lee WA, Lehtinen MK, Kirchhausen T, Haussler D, Jacobs FMJ, Gaudin R, Walsh CA
published in: Cell reports
information resource reference: The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles. Cell Rep. 2018 07 24; 24(4):973-986.e8.
journal title abbreviation: Cell Rep
publication date: 2018-07-24T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Configuration of clathrin trimers: evidence from electron microscopy.
PubMed Identifier: 3805786
author list: Kirchhausen T, Harrison SC, Heuser J
published in: Journal of ultrastructure and molecular structure research
information resource reference: Configuration of clathrin trimers: evidence from electron microscopy. J Ultrastruct Mol Struct Res. 1986 Mar; 94(3):199-208.
journal title abbreviation: J Ultrastruct Mol Struct Res
publication date: 1986-03-01T00:00:00
year: 1986
type: Academic Article
type: Article
type: Document
type: Information Resource

A clathrin-binding site in the hinge of the beta 2 chain of mammalian AP-2 complexes.
PubMed Identifier: 8537368
author list: Shih W, Gallusser A, Kirchhausen T
published in: The Journal of biological chemistry
information resource reference: A clathrin-binding site in the hinge of the beta 2 chain of mammalian AP-2 complexes. J Biol Chem. 1995 Dec 29; 270(52):31083-90.
journal title abbreviation: J Biol Chem
publication date: 1995-12-29T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1088521
type: Authorship
author rank in publication: 13
linked author: Kirchhausen, Tomas
linked information resource: Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure.

Divalent cation sites in tomato bushy stunt virus. Difference maps at 2-9 A resolution.
PubMed Identifier: 6417343
author list: Hogle J, Kirchhausen T, Harrison SC
published in: Journal of molecular biology
information resource reference: Divalent cation sites in tomato bushy stunt virus. Difference maps at 2-9 A resolution. J Mol Biol. 1983 Nov 25; 171(1):95-100.
journal title abbreviation: J Mol Biol
publication date: 1983-11-25T00:00:00
year: 1983
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1089462
type: Authorship
author rank in publication: 5
linked author: Kirchhausen, Tomas
linked information resource: Reconstitution of Clathrin Coat Disassembly for Fluorescence Microscopy and Single-Molecule Analysis.

Reconstitution of Clathrin Coat Disassembly for Fluorescence Microscopy and Single-Molecule Analysis.
PubMed Identifier: 30129014
author list: Böcking T, Upadhyayula S, Rapoport I, Capraro BR, Kirchhausen T
published in: Methods in molecular biology (Clifton, N.J.)
information resource reference: Reconstitution of Clathrin Coat Disassembly for Fluorescence Microscopy and Single-Molecule Analysis. Methods Mol Biol. 2018; 1847:121-146.
journal title abbreviation: Methods Mol Biol
publication date: 2018-01-01T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling.
PubMed Identifier: 20947020
author list: Yu A, Xing Y, Harrison SC, Kirchhausen T
published in: Structure (London, England : 1993)
information resource reference: Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling. Structure. 2010 Oct 13; 18(10):1311-20.
journal title abbreviation: Structure
publication date: 2010-10-13T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Actin dynamics counteract membrane tension during clathrin-mediated endocytosis.
PubMed Identifier: 21841790
author list: Boulant S, Kural C, Zeeh JC, Ubelmann F, Kirchhausen T
published in: Nature cell biology
information resource reference: Actin dynamics counteract membrane tension during clathrin-mediated endocytosis. Nat Cell Biol. 2011 Aug 14; 13(9):1124-31.
journal title abbreviation: Nat Cell Biol
publication date: 2011-08-14T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Deep-etch views of clathrin assemblies.
PubMed Identifier: 2870198
author list: Heuser J, Kirchhausen T
published in: Journal of ultrastructure research
information resource reference: Deep-etch views of clathrin assemblies. J Ultrastruct Res. 1985 Jul-Aug; 92(1-2):1-27.
journal title abbreviation: J Ultrastruct Res
publication date: 1985-07-01T00:00:00
year: 1985
type: Academic Article
type: Article
type: Document
type: Information Resource

Serum low density lipoproteins with mitogenic effect on cultured aortic smooth muscle cells.
PubMed Identifier: 7066069
author list: Fless GM, Kirchhausen T, Fischer-Dzoga K, Wissler RW, Scanu AM
published in: Atherosclerosis
information resource reference: Serum low density lipoproteins with mitogenic effect on cultured aortic smooth muscle cells. Atherosclerosis. 1982 Feb; 41(2-3):171-83.
journal title abbreviation: Atherosclerosis
publication date: 1982-02-01T00:00:00
year: 1982
type: Academic Article
type: Article
type: Document
type: Information Resource

The first five seconds in the life of a clathrin-coated pit.
PubMed Identifier: 22863004
author list: Cocucci E, Aguet F, Boulant S, Kirchhausen T
published in: Cell
information resource reference: The first five seconds in the life of a clathrin-coated pit. Cell. 2012 Aug 03; 150(3):495-507.
journal title abbreviation: Cell
publication date: 2012-08-03T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Bending membranes.
PubMed Identifier: 22945258
author list: Kirchhausen T
published in: Nature cell biology
information resource reference: Bending membranes. Nat Cell Biol. 2012 Sep; 14(9):906-8.
journal title abbreviation: Nat Cell Biol
publication date: 2012-09-01T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis.
PubMed Identifier: 18413242
author list: Kirchhausen T, Macia E, Pelish HE
published in: Methods in enzymology
information resource reference: Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis. Methods Enzymol. 2008; 438:77-93.
journal title abbreviation: Methods Enzymol
publication date: 2008-01-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2.
PubMed Identifier: 2495531
author list: Kirchhausen T, Nathanson KL, Matsui W, Vaisberg A, Chow EP, Burne C, Keen JH, Davis AE
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2. Proc Natl Acad Sci U S A. 1989 Apr; 86(8):2612-6.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1989-04-01T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular cloning and complete amino acid sequence of AP50, an assembly protein associated with clathrin-coated vesicles.
PubMed Identifier: 3148444
author list: Thurieau C, Brosius J, Burne C, Jolles P, Keen JH, Mattaliano RJ, Chow EP, Ramachandran KL, Kirchhausen T
published in: DNA (Mary Ann Liebert, Inc.)
information resource reference: Molecular cloning and complete amino acid sequence of AP50, an assembly protein associated with clathrin-coated vesicles. DNA. 1988 Dec; 7(10):663-9.
journal title abbreviation: DNA
publication date: 1988-12-01T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating.
PubMed Identifier: 15502813
author list: Fotin A, Cheng Y, Grigorieff N, Walz T, Harrison SC, Kirchhausen T
published in: Nature
information resource reference: Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating. Nature. 2004 Dec 02; 432(7017):649-53.
journal title abbreviation: Nature
publication date: 2004-10-24T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Clathrin heavy chain: molecular cloning and complete primary structure.
PubMed Identifier: 3480512
author list: Kirchhausen T, Harrison SC, Chow EP, Mattaliano RJ, Ramachandran KL, Smart J, Brosius J
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Clathrin heavy chain: molecular cloning and complete primary structure. Proc Natl Acad Sci U S A. 1987 Dec; 84(24):8805-9.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1987-12-01T00:00:00
year: 1987
type: Academic Article
type: Article
type: Document
type: Information Resource

Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis.
PubMed Identifier: 20038786
author list: Thiery J, Keefe D, Saffarian S, Martinvalet D, Walch M, Boucrot E, Kirchhausen T, Lieberman J
published in: Blood
information resource reference: Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis. Blood. 2010 Feb 25; 115(8):1582-93.
journal title abbreviation: Blood
publication date: 2009-12-28T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Formation of the postmitotic nuclear envelope from extended ER cisternae precedes nuclear pore assembly.
PubMed Identifier: 21825076
author list: Lu L, Ladinsky MS, Kirchhausen T
published in: The Journal of cell biology
information resource reference: Formation of the postmitotic nuclear envelope from extended ER cisternae precedes nuclear pore assembly. J Cell Biol. 2011 Aug 08; 194(3):425-40.
journal title abbreviation: J Cell Biol
publication date: 2011-08-08T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Sanyal, Anwesha
eCommons Login: AS958
first name: Anwesha
last name: Sanyal
full name: Anwesha Sanyal, Ph.D.
has faculty rank: Fellow or Post Doc
Person ID: 174753
person in primary position: Research Fellow in Cell Biology
type: Agent
type: Person
preferred title: Research Fellow in Cell Biology

Immunoelectron microscopic evidence for the extended conformation of light chains in clathrin trimers.
PubMed Identifier: 7683673
author list: Kirchhausen T, Toyoda T
published in: The Journal of biological chemistry
information resource reference: Immunoelectron microscopic evidence for the extended conformation of light chains in clathrin trimers. J Biol Chem. 1993 May 15; 268(14):10268-73.
journal title abbreviation: J Biol Chem
publication date: 1993-05-15T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Location of the domains of ICAM-1 by immunolabeling and single-molecule electron microscopy.
PubMed Identifier: 8095966
author list: Kirchhausen T, Staunton DE, Springer TA
published in: Journal of leukocyte biology
information resource reference: Location of the domains of ICAM-1 by immunolabeling and single-molecule electron microscopy. J Leukoc Biol. 1993 Mar; 53(3):342-6.
journal title abbreviation: J Leukoc Biol
publication date: 1993-03-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Microbiology
type: Department
type: Organization

Use of biomimetic diversity-oriented synthesis to discover galanthamine-like molecules with biological properties beyond those of the natural product.
PubMed Identifier: 11439080
author list: Pelish HE, Westwood NJ, Feng Y, Kirchhausen T, Shair MD
published in: Journal of the American Chemical Society
information resource reference: Use of biomimetic diversity-oriented synthesis to discover galanthamine-like molecules with biological properties beyond those of the natural product. J Am Chem Soc. 2001 Jul 11; 123(27):6740-1.
journal title abbreviation: J Am Chem Soc
publication date: 2001-07-11T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 109190
type: Authorship
author rank in publication: 2
linked author: Kirchhausen, Tomas
linked information resource: Divalent cation sites in tomato bushy stunt virus. Difference maps at 2-9 A resolution.

Stoichiometric interaction of the epidermal growth factor receptor with the clathrin-associated protein complex AP-2.
PubMed Identifier: 7822287
author list: Sorkin A, McKinsey T, Shih W, Kirchhausen T, Carpenter G
published in: The Journal of biological chemistry
information resource reference: Stoichiometric interaction of the epidermal growth factor receptor with the clathrin-associated protein complex AP-2. J Biol Chem. 1995 Jan 13; 270(2):619-25.
journal title abbreviation: J Biol Chem
publication date: 1995-01-13T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Detection of molecular particles in live cells via machine learning.
PubMed Identifier: 17431884
author list: Jiang S, Zhou X, Kirchhausen T, Wong ST
published in: Cytometry. Part A : the journal of the International Society for Analytical Cytology
information resource reference: Detection of molecular particles in live cells via machine learning. Cytometry A. 2007 Aug; 71(8):563-75.
journal title abbreviation: Cytometry A
publication date: 2007-08-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

The length of vesicular stomatitis virus particles dictates a need for actin assembly during clathrin-dependent endocytosis.
PubMed Identifier: 20941355
author list: Cureton DK, Massol RH, Whelan SP, Kirchhausen T
published in: PLoS pathogens
information resource reference: The length of vesicular stomatitis virus particles dictates a need for actin assembly during clathrin-dependent endocytosis. PLoS Pathog. 2010 Sep 30; 6(9):e1001127.
journal title abbreviation: PLoS Pathog
publication date: 2010-09-30T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 109338
type: Authorship
author rank in publication: 6
linked author: Kirchhausen, Tomas
linked information resource: Dynasore, a cell-permeable inhibitor of dynamin.

Role of the regulatory domain of the EGF-receptor cytoplasmic tail in selective binding of the clathrin-associated complex AP-2.
PubMed Identifier: 8548289
author list: Boll W, Gallusser A, Kirchhausen T
published in: Current biology : CB
information resource reference: Role of the regulatory domain of the EGF-receptor cytoplasmic tail in selective binding of the clathrin-associated complex AP-2. Curr Biol. 1995 Oct 01; 5(10):1168-78.
journal title abbreviation: Curr Biol
publication date: 1995-10-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

T cells induce extended class II MHC compartments in dendritic cells in a Toll-like receptor-dependent manner.
PubMed Identifier: 14530329
author list: Boes M, Bertho N, Cerny J, Op den Brouw M, Kirchhausen T, Ploegh H
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: T cells induce extended class II MHC compartments in dendritic cells in a Toll-like receptor-dependent manner. J Immunol. 2003 Oct 15; 171(8):4081-8.
journal title abbreviation: J Immunol
publication date: 2003-10-15T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 12282
type: Authorship
author rank in publication: 10
linked author: Kirchhausen, Tomas
linked information resource: Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.

The transcription factor NFAT3 mediates neuronal survival.
PubMed Identifier: 15537643
author list: Benedito AB, Lehtinen M, Massol R, Lopes UG, Kirchhausen T, Rao A, Bonni A
published in: The Journal of biological chemistry
information resource reference: The transcription factor NFAT3 mediates neuronal survival. J Biol Chem. 2005 Jan 28; 280(4):2818-25.
journal title abbreviation: J Biol Chem
publication date: 2004-11-10T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Atherogenic diets and neutral-lipid organization in plasma low density lipoproteins.
PubMed Identifier: 223602
author list: Kirchhausen T, Untracht SH, Fless GM, Scanu AM
published in: Atherosclerosis
information resource reference: Atherogenic diets and neutral-lipid organization in plasma low density lipoproteins. Atherosclerosis. 1979 May; 33(1):59-70.
journal title abbreviation: Atherosclerosis
publication date: 1979-05-01T00:00:00
year: 1979
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1125598
type: Authorship
author rank in publication: 27
linked author: Kirchhausen, Tomas
linked information resource: Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution.

Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution.
PubMed Identifier: 30655415
author list: Gao R, Asano SM, Upadhyayula S, Pisarev I, Milkie DE, Liu TL, Singh V, Graves A, Huynh GH, Zhao Y, Bogovic J, Colonell J, Ott CM, Zugates C, Tappan S, Rodriguez A, Mosaliganti KR, Sheu SH, Pasolli HA, Pang S, Xu CS, Megason SG, Hess H, Lippincott-Schwartz J, Hantman A, Rubin GM, Kirchhausen T, Saalfeld S, Aso Y, Boyden ES, Betzig E
published in: Science (New York, N.Y.)
information resource reference: Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution. Science. 2019 01 18; 363(6424).
journal title abbreviation: Science
publication date: 2019-01-18T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Sequence of the rat alpha c large chain of the clathrin associated protein complex AP-2.
PubMed Identifier: 2402467
author list: Tucker KL, Nathanson K, Kirchhausen T
published in: Nucleic acids research
information resource reference: Sequence of the rat alpha c large chain of the clathrin associated protein complex AP-2. Nucleic Acids Res. 1990 Sep 11; 18(17):5306.
journal title abbreviation: Nucleic Acids Res
publication date: 1990-09-11T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.
PubMed Identifier: 20228810
author list: Anitei M, Stange C, Parshina I, Baust T, Schenck A, Raposo G, Kirchhausen T, Hoflack B
published in: Nature cell biology
information resource reference: Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN. Nat Cell Biol. 2010 Apr; 12(4):330-40.
journal title abbreviation: Nat Cell Biol
publication date: 2010-03-14T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of ligand-independent Notch signal through intracellular trafficking.
PubMed Identifier: 23060962
author list: Hori K, Sen A, Kirchhausen T, Artavanis-Tsakonas S
published in: Communicative & integrative biology
information resource reference: Regulation of ligand-independent Notch signal through intracellular trafficking. Commun Integr Biol. 2012 Jul 01; 5(4):374-6.
journal title abbreviation: Commun Integr Biol
publication date: 2012-07-01T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 145453
type: Authorship
author rank in publication: 3
linked author: Kirchhausen, Tomas
linked information resource: Studies on the inhibition of endosome fusion by GTPgammaS-bound ARF.

Saccharomyces cerevisiae Apl2p, a homologue of the mammalian clathrin AP beta subunit, plays a role in clathrin-dependent Golgi functions.
PubMed Identifier: 7615679
author list: Rad MR, Phan HL, Kirchrath L, Tan PK, Kirchhausen T, Hollenberg CP, Payne GS
published in: Journal of cell science
information resource reference: Saccharomyces cerevisiae Apl2p, a homologue of the mammalian clathrin AP beta subunit, plays a role in clathrin-dependent Golgi functions. J Cell Sci. 1995 Apr; 108 ( Pt 4):1605-15.
journal title abbreviation: J Cell Sci
publication date: 1995-04-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Cell Biology of Endosomal Escape
end date: 2029-07-31
principal investigator name: KIRCHHAUSEN, TOMAS
start date: 2019-03-01
type: Grant
sponsor award id: R35GM130386

Principal Investigator
type: Researcher Role
researcher role of: Kirchhausen, Tomas
contributes to: Cell Biology of Endosomal Escape

Authorship 127727
type: Authorship
author rank in publication: 1
linked author: Kirchhausen, Tomas
linked information resource: AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast.

F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in human subjects.
PubMed Identifier: 30822429
author list: Calzoni E, Platt CD, Keles S, Kuehn HS, Beaussant-Cohen S, Zhang Y, Pazmandi J, Lanzi G, Pala F, Tahiat A, Artac H, Heredia RJ, Dmytrus J, Reisli I, Uygun V, Uygun D, Bingol A, Basaran E, Djenouhat K, Benhalla N, Bendahmane C, Emiroglu M, Kirchhausen T, Pasham M, Jones J, Wallace JG, Zheng L, Boisson B, Porta F, Rosenzweig SD, Su H, Giliani S, Lenardo M, Geha RS, Boztug K, Chou J, Notarangelo LD
published in: The Journal of allergy and clinical immunology
information resource reference: F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in human subjects. J Allergy Clin Immunol. 2019 06; 143(6):2317-2321.e12.
journal title abbreviation: J Allergy Clin Immunol
publication date: 2019-02-26T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Clathrin
MeSH DescriptorUI: D002966
MeSH semantic group name: Chemicals & Drugs
number of authors: 110
number of publications: 267
uniqueness weight: 0.879748
type: Concept

Authorship 114428
type: Authorship
author rank in publication: 10
linked author: Kirchhausen, Tomas
linked information resource: Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability.

Endosomes
MeSH DescriptorUI: D011992
MeSH semantic group name: Anatomy
number of authors: 312
number of publications: 559
uniqueness weight: 0.766766
type: Concept

Authorship 1140897
type: Authorship
author rank in publication: 23
linked author: Kirchhausen, Tomas
linked information resource: F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in human subjects.

Endocytosis
MeSH DescriptorUI: D004705
MeSH semantic group name: Physiology
number of authors: 479
number of publications: 967
uniqueness weight: 0.71742
type: Concept

Clathrin-Coated Vesicles
MeSH DescriptorUI: D022163
MeSH semantic group name: Anatomy
number of authors: 30
number of publications: 66
uniqueness weight: 0.955352
type: Concept

Authorship 1148843
type: Authorship
author rank in publication: 10
linked author: Kirchhausen, Tomas
linked information resource: Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR-Cas9 genome editing.

Coated Pits, Cell-Membrane
MeSH DescriptorUI: D003034
MeSH semantic group name: Anatomy
number of authors: 28
number of publications: 74
uniqueness weight: 0.969476
type: Concept

Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR-Cas9 genome editing.
PubMed Identifier: 31015609
author list: Paulsen BS, Mandal PK, Frock RL, Boyraz B, Yadav R, Upadhyayula S, Gutierrez-Martinez P, Ebina W, Fasth A, Kirchhausen T, Talkowski ME, Agarwal S, Alt FW, Rossi DJ
published in: Nature biomedical engineering
information resource reference: Ectopic expression of RAD52 and dn53BP1 improves homology-directed repair during CRISPR-Cas9 genome editing. Nat Biomed Eng. 2017 11; 1(11):878-888.
journal title abbreviation: Nat Biomed Eng
publication date: 2017-10-09T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Cell Biology
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type: Organization

Medicine
type: Department
type: Organization

Pediatrics
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type: Organization

Systems Biology
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type: Organization

MCB Board of Tutor
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type: Organization

Rheumatology
type: Division
type: Organization

Immunology
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type: Organization

Brigham and Women's Hospital
type: Organization

Boston Children's Hospital
type: Organization

Faculty of Arts & Sciences
type: Organization

Harvard Medical School
type: Organization

Immune Disease Institute
type: Organization

Rudner, David
eCommons Login: DZR1
first name: David
last name: Rudner
full name: David Z. Rudner, Ph.D.
has faculty rank: Full Professor
latitude: 42.33594500000000
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Person ID: 16968
person in primary position: Professor of Microbiology
type: Agent
type: Person
preferred title: Professor of Microbiology

Harrison, Stephen
eCommons Login: SCH1
first name: Stephen
last name: Harrison
full name: Stephen Coplan Harrison, Ph.D.
has faculty rank: Full Professor
latitude: 42.33738860000000
longitude: -71.10437290000000
Person ID: 74002
person in primary position: Giovanni Armenise - Harvard Professor of Basic Biomedical Science
type: Agent
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preferred title: Giovanni Armenise - Harvard Professor of Basic Biomedical Science

Rapoport, Tom
eCommons Login: TAR1
first name: Tom
last name: Rapoport
full name: Tom A. Rapoport, Ph.D.
has faculty rank: Full Professor
latitude: 42.33590010000000
longitude: -71.10546620000000
Person ID: 59457
person in primary position: Don W. Fawcett Professor of Cell Biology
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preferred title: Don W. Fawcett Professor of Cell Biology

selected publications
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Gygi, Steven
eCommons Login: SPG4
first name: Steven
last name: Gygi
full name: Steven P. Gygi, Ph.D.
has faculty rank: Full Professor
latitude: 42.33588600000000
longitude: -71.10514600000000
Person ID: 28969
person in primary position: Professor of Cell Biology
type: Agent
type: Person
preferred title: Professor of Cell Biology

Authorship 1159346
type: Authorship
author rank in publication: 19
linked author: Kirchhausen, Tomas
linked information resource: Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling.

Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling.
PubMed Identifier: 31167147
author list: Pascolutti R, Algisi V, Conte A, Raimondi A, Pasham M, Upadhyayula S, Gaudin R, Maritzen T, Barbieri E, Caldieri G, Tordonato C, Confalonieri S, Freddi S, Malabarba MG, Maspero E, Polo S, Tacchetti C, Haucke V, Kirchhausen T, Di Fiore PP, Sigismund S
published in: Cell reports
information resource reference: Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling. Cell Rep. 2019 06 04; 27(10):3049-3061.e6.
journal title abbreviation: Cell Rep
publication date: 2019-06-04T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Carroll, Elisabeth
eCommons Login: EMC3
first name: Elisabeth
last name: Carroll
full name: Elisabeth M. Carroll, Dr.Pharm.
has faculty rank: Other Faculty
latitude: 42.33594500000000
longitude: -71.10295800000000
Person ID: 29293
person in primary position: Research Associate in Pediatrics
type: Agent
type: Person
preferred title: Research Associate in Pediatrics

Mitchison, Timothy
eCommons Login: TJM8
first name: Timothy
last name: Mitchison
full name: Timothy J. Mitchison, Ph.D.
has faculty rank: Full Professor
latitude: 42.33594500000000
longitude: -71.10295800000000
Person ID: 31112
person in primary position: Hasib Sabbagh Professor of Systems Biology
type: Agent
type: Person
preferred title: Hasib Sabbagh Professor of Systems Biology

Lory, Stephen
eCommons Login: SL24
first name: Stephen
last name: Lory
full name: Stephen Lory, Ph.D.
has faculty rank: Full Professor
latitude: 42.33594500000000
longitude: -71.10295800000000
Person ID: 59594
person in primary position: Professor of Microbiology
type: Agent
type: Person
preferred title: Professor of Microbiology

Hsu, Victor
eCommons Login: VWH1
first name: Victor
last name: Hsu
full name: Victor Wee Hsu, M.D.
has faculty rank: Full Professor
latitude: 42.33729300000000
longitude: -71.10763500000000
Person ID: 9687
person in primary position: Professor of Medicine
type: Agent
type: Person
preferred title: Professor of Medicine

Rapoport, Iris
eCommons Login: IR2
first name: Iris
last name: Rapoport
full name: Iris Rapoport, Ph.D.
has faculty rank: Other Faculty
latitude: 42.33594500000000
longitude: -71.10295800000000
Person ID: 36724
person in primary position: Research Associate in Cell Biology
type: Agent
type: Person
preferred title: Research Associate in Cell Biology

Carroll, Michael
eCommons Login: MCC7
first name: Michael
last name: Carroll
full name: Michael C. Carroll, Ph.D.
has faculty rank: Full Professor
latitude: 42.33594500000000
longitude: -71.10295800000000
Person ID: 3535
person in primary position: Professor of Pediatrics (Pathology)
type: Agent
type: Person
preferred title: Professor of Pediatrics (Pathology)

Authorship 156796
type: Authorship
author rank in publication: 4
linked author: Kirchhausen, Tomas
linked information resource: Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization.

Authorship 120217
type: Authorship
author rank in publication: 6
linked author: Kirchhausen, Tomas
linked information resource: Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide.

Professor of Microbiology
is primary position: true
position in department: Microbiology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Microbiology
position in organization: Harvard Medical School

Research Associate in Cell Biology
is primary position: true
position in department: Cell Biology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Research Associate in Cell Biology
position in organization: Immune Disease Institute

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Rheumatology
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Brigham and Women's Hospital

Authorship 143917
type: Authorship
author rank in publication: 4
linked author: Kirchhausen, Tomas
linked information resource: Parallel dimers and anti-parallel tetramers formed by epidermal growth factor receptor pathway substrate clone 15.

Authorship 1218977
type: Authorship
author rank in publication: 19
linked author: Kirchhausen, Tomas
linked information resource: Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells.

Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells.
PubMed Identifier: 31949053
author list: Hoffman DP, Shtengel G, Xu CS, Campbell KR, Freeman M, Wang L, Milkie DE, Pasolli HA, Iyer N, Bogovic JA, Stabley DR, Shirinifard A, Pang S, Peale D, Schaefer K, Pomp W, Chang CL, Lippincott-Schwartz J, Kirchhausen T, Solecki DJ, Betzig E, Hess HF
published in: Science (New York, N.Y.)
information resource reference: Correlative three-dimensional super-resolution and block-face electron microscopy of whole vitreously frozen cells. Science. 2020 01 17; 367(6475).
journal title abbreviation: Science
publication date: 2020-01-17T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1220598
type: Authorship
author rank in publication: 12
linked author: Kirchhausen, Tomas
linked information resource: Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic.

Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic.
PubMed Identifier: 31962345
author list: He K, Song E, Upadhyayula S, Dang S, Gaudin R, Skillern W, Bu K, Capraro BR, Rapoport I, Kusters I, Ma M, Kirchhausen T
published in: The Journal of cell biology
information resource reference: Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic. J Cell Biol. 2020 03 02; 219(3).
journal title abbreviation: J Cell Biol
publication date: 2020-03-02T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 178408
type: Authorship
author rank in publication: 1
linked author: Kirchhausen, Tomas
linked information resource: Wiskott-Aldrich syndrome: a gene, a multifunctional protein and the beginnings of an explanation.

Authorship 162667
type: Authorship
author rank in publication: 4
linked author: Kirchhausen, Tomas
linked information resource: Endocytosis is not required for the selective lipid uptake mediated by murine SR-BI.

Authorship 170929
type: Authorship
author rank in publication: 7
linked author: Kirchhausen, Tomas
linked information resource: Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis.

Authorship 178259
type: Authorship
author rank in publication: 9
linked author: Kirchhausen, Tomas
linked information resource: Interaction of tyrosine-based sorting signals with clathrin-associated proteins.

Oligomerization of the Vesicular Stomatitis Virus Phosphoprotein Is Dispensable for mRNA Synthesis but Facilitates RNA Replication.
PubMed Identifier: 32321813
author list: Bloyet LM, Morin B, Brusic V, Gardner E, Ross RA, Vadakkan T, Kirchhausen T, Whelan SPJ
published in: Journal of virology
information resource reference: Oligomerization of the Vesicular Stomatitis Virus Phosphoprotein Is Dispensable for mRNA Synthesis but Facilitates RNA Replication. J Virol. 2020 06 16; 94(13).
journal title abbreviation: J Virol
publication date: 2020-06-16T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1241025
type: Authorship
author rank in publication: 7
linked author: Kirchhausen, Tomas
linked information resource: Oligomerization of the Vesicular Stomatitis Virus Phosphoprotein Is Dispensable for mRNA Synthesis but Facilitates RNA Replication.

Authorship 17715
type: Authorship
author rank in publication: 8
linked author: Kirchhausen, Tomas
linked information resource: Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity.

Authorship 200588
type: Authorship
author rank in publication: 3
linked author: Kirchhausen, Tomas
linked information resource: Regulation of ligand-independent Notch signal through intracellular trafficking.

Authorship 1255900
type: Authorship
author rank in publication: 11
linked author: Kirchhausen, Tomas
linked information resource: Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2.

Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2.
PubMed Identifier: 32511398
author list: Kang YL, Chou YY, Rothlauf PW, Liu Z, Soh TK, Cureton D, Case JB, Chen RE, Diamond MS, Whelan SPJ, Kirchhausen T
published in: bioRxiv : the preprint server for biology
information resource reference: Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2. bioRxiv. 2020 Jun 15.
journal title abbreviation: bioRxiv
publication date: 2020-06-15T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 133873
type: Authorship
author rank in publication: 5
linked author: Kirchhausen, Tomas
linked information resource: A motif in the clathrin heavy chain required for the Hsc70/auxilin uncoating reaction.

Authorship 1274474
type: Authorship
author rank in publication: 11
linked author: Kirchhausen, Tomas
linked information resource: Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2.

Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2.
PubMed Identifier: 32764148
author list: Kang YL, Chou YY, Rothlauf PW, Liu Z, Soh TK, Cureton D, Case JB, Chen RE, Diamond MS, Whelan SPJ, Kirchhausen T
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2. Proc Natl Acad Sci U S A. 2020 08 25; 117(34):20803-20813.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2020-08-06T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Professor of Cell Biology
is primary position: true
position in department: Cell Biology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Cell Biology
position in organization: Harvard Medical School

Authorship 190627
type: Authorship
author rank in publication: 6
linked author: Kirchhausen, Tomas
linked information resource: Multivalent binding of nonnative substrate proteins by the chaperonin GroEL.

BCMP
type: Department
type: Organization

Authorship 1288264
type: Authorship
author rank in publication: 17
linked author: Kirchhausen, Tomas
linked information resource: HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.

HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.
PubMed Identifier: 32943500
author list: Magupalli VG, Negro R, Tian Y, Hauenstein AV, Di Caprio G, Skillern W, Deng Q, Orning P, Alam HB, Maliga Z, Sharif H, Hu JJ, Evavold CL, Kagan JC, Schmidt FI, Fitzgerald KA, Kirchhausen T, Li Y, Wu H
published in: Science (New York, N.Y.)
information resource reference: HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science. 2020 09 18; 369(6510).
journal title abbreviation: Science
publication date: 2020-09-18T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1290496
type: Authorship
author rank in publication: 18
linked author: Kirchhausen, Tomas
linked information resource: Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface.

Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface.
PubMed Identifier: 32961128
author list: Shipley FB, Dani N, Xu H, Deister C, Cui J, Head JP, Sadegh C, Fame RM, Shannon ML, Flores VI, Kishkovich T, Jang E, Klein EM, Goldey GJ, He K, Zhang Y, Holtzman MJ, Kirchhausen T, Wyart C, Moore CI, Andermann ML, Lehtinen MK
published in: Neuron
information resource reference: Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface. Neuron. 2020 11 25; 108(4):623-639.e10.
journal title abbreviation: Neuron
publication date: 2020-09-21T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 139085
type: Authorship
author rank in publication: 2
linked author: Kirchhausen, Tomas
linked information resource: Analysis of clathrin light chain-heavy chain interactions using truncated mutants of rat liver light chain LCB3.

Authorship 1299247
type: Authorship
author rank in publication: 15
linked author: Kirchhausen, Tomas
linked information resource: Design and Validation of a Human Brain Endothelial Microvessel-on-a-Chip Open Microfluidic Model Enabling Advanced Optical Imaging.

Design and Validation of a Human Brain Endothelial Microvessel-on-a-Chip Open Microfluidic Model Enabling Advanced Optical Imaging.
PubMed Identifier: 33117784
author list: Salman MM, Marsh G, Kusters I, Delincé M, Di Caprio G, Upadhyayula S, de Nola G, Hunt R, Ohashi KG, Gray T, Shimizu F, Sano Y, Kanda T, Obermeier B, Kirchhausen T
published in: Frontiers in bioengineering and biotechnology
information resource reference: Design and Validation of a Human Brain Endothelial Microvessel-on-a-Chip Open Microfluidic Model Enabling Advanced Optical Imaging. Front Bioeng Biotechnol. 2020; 8:573775.
journal title abbreviation: Front Bioeng Biotechnol
publication date: 2020-09-28T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 207881
type: Authorship
author rank in publication: 3
linked author: Kirchhausen, Tomas
linked information resource: Distinct dynamics of endocytic clathrin-coated pits and coated plaques.

Authorship 1303626
type: Authorship
author rank in publication: 20
linked author: Kirchhausen, Tomas
linked information resource: Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion.

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion.
PubMed Identifier: 33239446
author list: Zang R, Case JB, Yutuc E, Ma X, Shen S, Gomez Castro MF, Liu Z, Zeng Q, Zhao H, Son J, Rothlauf PW, Kreutzberger AJB, Hou G, Zhang H, Bose S, Wang X, Vahey MD, Mani K, Griffiths WJ, Kirchhausen T, Fremont DH, Guo H, Diwan A, Wang Y, Diamond MS, Whelan SPJ, Ding S
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion. Proc Natl Acad Sci U S A. 2020 12 15; 117(50):32105-32113.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2020-11-25T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1332315
type: Authorship
author rank in publication: 14
linked author: Kirchhausen, Tomas
linked information resource: Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis.

Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis.
PubMed Identifier: 33600895
author list: Chen YC, Dinavahi SS, Feng Q, Gowda R, Ramisetti S, Xia X, LaPenna KB, Chirasani VR, Cho SH, Hafenstein SL, Battu MB, Berg A, Sharma AK, Kirchhausen T, Dokholyan NV, Amin S, He P, Robertson GP
published in: Cancer letters
information resource reference: Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis. Cancer Lett. 2021 05 28; 506:107-119.
journal title abbreviation: Cancer Lett
publication date: 2021-02-16T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 15729
type: Authorship
author rank in publication: 5
linked author: Kirchhausen, Tomas
linked information resource: Actin dynamics counteract membrane tension during clathrin-mediated endocytosis.

Saminathan, Anand
eCommons Login: ans3740
first name: Anand
last name: Saminathan
full name: Anand Saminathan, Ph.D.
has faculty rank: Fellow or Post Doc
Person ID: 196953
person in primary position: Research Fellow in Cell Biology
type: Agent
type: Person
preferred title: Research Fellow in Cell Biology

Professor of Microbiology
is primary position: true
position in department: Microbiology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Microbiology
position in organization: Harvard Medical School

Authorship 1358663
type: Authorship
author rank in publication: 6
linked author: Kirchhausen, Tomas
linked information resource: PKC-phosphorylation of Liprin-a3 triggers phase separation and controls presynaptic active zone structure.

PKC-phosphorylation of Liprin-a3 triggers phase separation and controls presynaptic active zone structure.
PubMed Identifier: 34031393
author list: Emperador-Melero J, Wong MY, Wang SSH, de Nola G, Nyitrai H, Kirchhausen T, Kaeser PS
published in: Nature communications
information resource reference: PKC-phosphorylation of Liprin-a3 triggers phase separation and controls presynaptic active zone structure. Nat Commun. 2021 05 24; 12(1):3057.
journal title abbreviation: Nat Commun
publication date: 2021-05-24T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1362519
type: Authorship
author rank in publication: 7
linked author: Kirchhausen, Tomas
linked information resource: Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease.

Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease.
PubMed Identifier: 34100014
author list: Kreutzberger AJB, Sanyal A, Ojha R, Pyle JD, Vapalahti O, Balistreri G, Kirchhausen T
published in: bioRxiv : the preprint server for biology
information resource reference: Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease. bioRxiv. 2021 Aug 12.
journal title abbreviation: bioRxiv
publication date: 2021-08-12T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1364435
type: Authorship
author rank in publication: 13
linked author: Kirchhausen, Tomas
linked information resource: Inherited nuclear pore substructures template post-mitotic pore assembly.

Inherited nuclear pore substructures template post-mitotic pore assembly.
PubMed Identifier: 34129835
author list: Chou YY, Upadhyayula S, Houser J, He K, Skillern W, Scanavachi G, Dang S, Sanyal A, Ohashi KG, Di Caprio G, Kreutzberger AJB, Vadakkan TJ, Kirchhausen T
published in: Developmental cell
information resource reference: Inherited nuclear pore substructures template post-mitotic pore assembly. Dev Cell. 2021 06 21; 56(12):1786-1803.e9.
journal title abbreviation: Dev Cell
publication date: 2021-06-14T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Mechanism and Inhibition of SARS-CoV-2 Entry
end date: 2026-06-30
principal investigator name: WHELAN, SEAN PJ
start date: 2021-07-08
type: Grant
sponsor award id: R01AI163019

Co-Principal Investigator
type: Researcher Role
researcher role of: Kirchhausen, Tomas
contributes to: Mechanism and Inhibition of SARS-CoV-2 Entry

Authorship 1387313
type: Authorship
author rank in publication: 7
linked author: Kirchhausen, Tomas
linked information resource: Synergistic Block of SARS-CoV-2 Infection by Combined Drug Inhibition of the Host Entry Factors PIKfyve Kinase and TMPRSS2 Protease.

Synergistic Block of SARS-CoV-2 Infection by Combined Drug Inhibition of the Host Entry Factors PIKfyve Kinase and TMPRSS2 Protease.
PubMed Identifier: 34406858
author list: Kreutzberger AJB, Sanyal A, Ojha R, Pyle JD, Vapalahti O, Balistreri G, Kirchhausen T
published in: Journal of virology
information resource reference: Synergistic Block of SARS-CoV-2 Infection by Combined Drug Inhibition of the Host Entry Factors PIKfyve Kinase and TMPRSS2 Protease. J Virol. 2021 10 13; 95(21):e0097521.
journal title abbreviation: J Virol
publication date: 2021-08-18T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 184598
type: Authorship
author rank in publication: 5
linked author: Kirchhausen, Tomas
linked information resource: Structure of the PTEN-like region of auxilin, a detector of clathrin-coated vesicle budding.

Authorship 199316
type: Authorship
author rank in publication: 1
linked author: Kirchhausen, Tomas
linked information resource: DNA gyrase and its complexes with DNA: direct observation by electron microscopy.

Authorship 242472
type: Authorship
author rank in publication: 2
linked author: Kirchhausen, Tomas
linked information resource: Differential evanescence nanometry: live-cell fluorescence measurements with 10-nm axial resolution on the plasma membrane.

Authorship 257842
type: Authorship
author rank in publication: 6
linked author: Kirchhausen, Tomas
linked information resource: Molecular model for a complete clathrin lattice from electron cryomicroscopy.

Authorship 262870
type: Authorship
author rank in publication: 7
linked author: Kirchhausen, Tomas
linked information resource: Dynamics of intracellular clathrin/AP1- and clathrin/AP3-containing carriers.

Authorship 1438898
type: Authorship
author rank in publication: 8
linked author: Kirchhausen, Tomas
linked information resource: CD164 is a host factor for lymphocytic choriomeningitis virus entry.

CD164 is a host factor for lymphocytic choriomeningitis virus entry.
PubMed Identifier: 35235462
author list: Bakkers MJG, Moon-Walker A, Herlo R, Brusic V, Stubbs SH, Hastie KM, Saphire EO, Kirchhausen TL, Whelan SPJ
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: CD164 is a host factor for lymphocytic choriomeningitis virus entry. Proc Natl Acad Sci U S A. 2022 03 08; 119(10):e2119676119.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2022-03-02T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion.
PubMed Identifier: 35951767
author list: Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
published in: Science immunology
information resource reference: An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion. Sci Immunol. 2022 10 28; 7(76):eadd5446.
journal title abbreviation: Sci Immunol
publication date: 2022-08-11T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 168752
type: Authorship
author rank in publication: 5
linked author: Kirchhausen, Tomas
linked information resource: T cells induce extended class II MHC compartments in dendritic cells in a Toll-like receptor-dependent manner.

Authorship 1461919
type: Authorship
author rank in publication: 21
linked author: Kirchhausen, Tomas
linked information resource: SARS-CoV-2 requires acidic pH to infect cells.

SARS-CoV-2 requires acidic pH to infect cells.
PubMed Identifier: 35702155
author list: Kreutzberger AJB, Sanyal A, Saminathan A, Bloyet LM, Stumpf S, Liu Z, Ojha R, Patjas MT, Geneid A, Scanavachi G, Doyle CA, Somerville E, Bango Da Cunha Correira R, Di Caprio G, Toppila-Salmi S, Mäkitie A, Kiessling V, Vapalahti O, Whelan SPJ, Balistreri G, Kirchhausen T
published in: bioRxiv : the preprint server for biology
information resource reference: SARS-CoV-2 requires acidic pH to infect cells. bioRxiv. 2022 Jun 14.
journal title abbreviation: bioRxiv
publication date: 2022-06-14T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1477299
type: Authorship
author rank in publication: 19
linked author: Kirchhausen, Tomas
linked information resource: Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the pre-hairpin intermediate of the spike protein.

Authorship 1480427
type: Authorship
author rank in publication: 21
linked author: Kirchhausen, Tomas
linked information resource: SARS-CoV-2 requires acidic pH to infect cells.

Authorship 1492217
type: Authorship
author rank in publication: 2
linked author: Kirchhausen, Tomas
linked information resource: The beauty of simplicity in membrane biology.

Authorship 1491362
type: Authorship
author rank in publication: 27
linked author: Kirchhausen, Tomas
linked information resource: An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion.

Authorship 1488904
type: Authorship
author rank in publication: 19
linked author: Kirchhausen, Tomas
linked information resource: Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein.

Authorship 1497868
type: Authorship
author rank in publication: 15
linked author: Kirchhausen, Tomas
linked information resource: A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility.

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein.
PubMed Identifier: 36122200
author list: Yang K, Wang C, Kreutzberger AJB, Ojha R, Kuivanen S, Couoh-Cardel S, Muratcioglu S, Eisen TJ, White KI, Held RG, Subramanian S, Marcus K, Pfuetzner RA, Esquivies L, Doyle CA, Kuriyan J, Vapalahti O, Balistreri G, Kirchhausen T, Brunger AT
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein. Proc Natl Acad Sci U S A. 2022 10 04; 119(40):e2210990119.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2022-09-19T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the pre-hairpin intermediate of the spike protein.
PubMed Identifier: 35982670
author list: Yang K, Wang C, Kreutzberger AJB, Ojha R, Kuivanen S, Couoh-Cardel S, Muratcioglu S, Eisen TJ, White KI, Held RG, Subramanian S, Marcus K, Pfuetzner RA, Esquivies L, Doyle CA, Kuriyan J, Vapalahti O, Balistreri G, Kirchhausen T, Brunger AT
published in: bioRxiv : the preprint server for biology
information resource reference: Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the pre-hairpin intermediate of the spike protein. bioRxiv. 2022 Aug 11.
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SARS-CoV-2 requires acidic pH to infect cells.
PubMed Identifier: 36048924
author list: Kreutzberger AJB, Sanyal A, Saminathan A, Bloyet LM, Stumpf S, Liu Z, Ojha R, Patjas MT, Geneid A, Scanavachi G, Doyle CA, Somerville E, Correia RBDC, Di Caprio G, Toppila-Salmi S, Mäkitie A, Kiessling V, Vapalahti O, Whelan SPJ, Balistreri G, Kirchhausen T
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information resource reference: SARS-CoV-2 requires acidic pH to infect cells. Proc Natl Acad Sci U S A. 2022 09 20; 119(38):e2209514119.
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The beauty of simplicity in membrane biology.
PubMed Identifier: 36266490
author list: Stachowiak JC, Kirchhausen T
published in: Nature cell biology
information resource reference: The beauty of simplicity in membrane biology. Nat Cell Biol. 2022 Dec; 24(12):1682-1685.
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publication date: 2022-12-01T00:00:00
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A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility.
PubMed Identifier: 36055200
author list: Sheu SH, Upadhyayula S, Dupuy V, Pang S, Deng F, Wan J, Walpita D, Pasolli HA, Houser J, Sanchez-Martinez S, Brauchi SE, Banala S, Freeman M, Xu CS, Kirchhausen T, Hess HF, Lavis L, Li Y, Chaumont-Dubel S, Clapham DE
published in: Cell
information resource reference: A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility. Cell. 2022 09 01; 185(18):3390-3407.e18.
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Authorship 1509153
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linked information resource: Deep neural network automated segmentation of cellular structures in volume electron microscopy.

Deep neural network automated segmentation of cellular structures in volume electron microscopy.
PubMed Identifier: 36469001
author list: Gallusser B, Maltese G, Di Caprio G, Vadakkan TJ, Sanyal A, Somerville E, Sahasrabudhe M, O'Connor J, Weigert M, Kirchhausen T
published in: The Journal of cell biology
information resource reference: Deep neural network automated segmentation of cellular structures in volume electron microscopy. J Cell Biol. 2023 02 06; 222(2).
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Authorship 205798
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linked information resource: Recruitment of cellular clathrin to viral factories and disruption of clathrin-dependent trafficking.

Authorship 1533968
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linked information resource: Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor.

Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor.
PubMed Identifier: 36940324
author list: Yang K, Wang C, Kreutzberger AJB, White KI, Pfuetzner RA, Esquivies L, Kirchhausen T, Brunger AT
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information resource reference: Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor. Proc Natl Acad Sci U S A. 2023 03 28; 120(13):e2300360120.
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Hatzakis, Nikos
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Authorship 481223
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linked information resource: The clathrin endocytic pathway in viral infection.

Authorship 501279
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linked information resource: Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes.

Authorship 206185
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linked information resource: Exo1: a new chemical inhibitor of the exocytic pathway.

Authorship 1571348
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linked author: Kirchhausen, Tomas
linked information resource: Complete Protection from SARS-CoV-2 Lung Infection in Mice Through Combined Intranasal Delivery of PIKfyve Kinase and TMPRSS2 Protease Inhibitors.

Complete Protection from SARS-CoV-2 Lung Infection in Mice Through Combined Intranasal Delivery of PIKfyve Kinase and TMPRSS2 Protease Inhibitors.
PubMed Identifier: 37503261
author list: Kant R, Kareinen L, Ojha R, Strandin T, Saber SH, Lesnikova A, Kuivanen S, Sirnonen T, Joensuu M, Vapalahti O, Kirchhausen T, Kipar A, Balistreri G
published in: bioRxiv : the preprint server for biology
information resource reference: Complete Protection from SARS-CoV-2 Lung Infection in Mice Through Combined Intranasal Delivery of PIKfyve Kinase and TMPRSS2 Protease Inhibitors. bioRxiv. 2023 Jul 20.
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Authorship 1583693
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linked information resource: A spatiotemporal Notch interaction map from plasma membrane to nucleus.

Authorship 1585408
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linked information resource: A Serotonergic Axon-Cilium Synapse Drives Nuclear Signaling to Maintain Chromatin Accessibility.

A spatiotemporal Notch interaction map from plasma membrane to nucleus.
PubMed Identifier: 37527352
author list: Martin AP, Bradshaw GA, Eisert RJ, Egan ED, Tveriakhina L, Rogers JM, Dates AN, Scanavachi G, Aster JC, Kirchhausen T, Kalocsay M, Blacklow SC
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A Serotonergic Axon-Cilium Synapse Drives Nuclear Signaling to Maintain Chromatin Accessibility.
PubMed Identifier: 37613506
author list: Sheu SH, Upadhyayula S, Dupuy V, Pang S, Deng F, Wan J, Walpita D, Pasolli HA, Houser J, Sanchez-Martinez S, Brauchi SE, Banala S, Freeman M, Xu CS, Kirchhausen T, Hess HF, Lavis L, Li Y, Chaumont-Dubel S, Clapham DE
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information resource reference: A Serotonergic Axon-Cilium Synapse Drives Nuclear Signaling to Maintain Chromatin Accessibility. Microsc Microanal. 2023 Jul 22; 29(29 Suppl 1):1091.
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Authorship 371736
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linked information resource: Chemical genetic screening identifies sulfonamides that raise organellar pH and interfere with membrane traffic.

Authorship 1596713
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linked information resource: Temporal Dynamics and Stoichiometry in Notch Signaling - from Notch Synaptic Complex Formation to NICD Nuclear Entry.

Temporal Dynamics and Stoichiometry in Notch Signaling - from Notch Synaptic Complex Formation to NICD Nuclear Entry.
PubMed Identifier: 37808809
author list: Tveriakhina L, Scanavachi G, Egan ED, Correia RBDC, Martin AP, Rogers JM, Yodh JS, Aster JC, Kirchhausen T, Blacklow SC
published in: bioRxiv : the preprint server for biology
information resource reference: Temporal Dynamics and Stoichiometry in Notch Signaling - from Notch Synaptic Complex Formation to NICD Nuclear Entry. bioRxiv. 2023 Sep 28.
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Authorship 461780
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linked information resource: Saccharomyces cerevisiae Apl2p, a homologue of the mammalian clathrin AP beta subunit, plays a role in clathrin-dependent Golgi functions.

Authorship 178152
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linked author: Kirchhausen, Tomas
linked information resource: Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210.

Authorship 465095
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linked information resource: Clathrin adaptors really adapt.

Authorship 1611349
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linked information resource: Deep learning assisted single particle tracking for automated correlation between diffusion and function.

Deep learning assisted single particle tracking for automated correlation between diffusion and function.
PubMed Identifier: 38014323
author list: Kæstel-Hansen J, de Sautu M, Saminathan A, Scanavachi G, Da Cunha Correia RFB, Nielsen AJ, Bleshøy SV, Boomsma W, Kirchhausen T, Hatzakis NS
published in: bioRxiv : the preprint server for biology
information resource reference: Deep learning assisted single particle tracking for automated correlation between diffusion and function. bioRxiv. 2023 Nov 17.
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Authorship 1623121
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linked information resource: Constitutive Endolysosomal Perforation in Neurons allows Induction of a-Synuclein Aggregation by Internalized Pre-Formed Fibrils.

Constitutive Endolysosomal Perforation in Neurons allows Induction of a-Synuclein Aggregation by Internalized Pre-Formed Fibrils.
PubMed Identifier: 38260258
author list: Sanyal A, Scanavachi G, Somerville E, Saminathan A, Nair A, Oikonomou A, Hatzakis NS, Kirchhausen T
published in: bioRxiv : the preprint server for biology
information resource reference: Constitutive Endolysosomal Perforation in Neurons allows Induction of a-Synuclein Aggregation by Internalized Pre-Formed Fibrils. bioRxiv. 2024 Jan 01.
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Authorship 574859
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linked information resource: Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation.

Authorship 180733
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linked information resource: Assembly of clathrin coats disrupts the association between Eps15 and AP-2 adaptors.

Authorship 1631202
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linked author: Kirchhausen, Tomas
linked information resource: Deep learning assisted single particle tracking for automated correlation between diffusion and function.

Deep learning assisted single particle tracking for automated correlation between diffusion and function.
PubMed Identifier: 38352328
author list: Hatzakis N, Kaestel-Hansen J, de Sautu M, Saminathan A, Scanavachi G, Correia R, Nielsen AJ, Bleshoey S, Boomsma W, Kirchhausen T
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information resource reference: Deep learning assisted single particle tracking for automated correlation between diffusion and function. Res Sq. 2024 Feb 02.
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Authorship 558338
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linked information resource: Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling.

Authorship 1642873
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linked author: Kirchhausen, Tomas
linked information resource: Temporal dynamics and stoichiometry in human Notch signaling from Notch synaptic complex formation to nuclear entry of the Notch intracellular domain.

Temporal dynamics and stoichiometry in human Notch signaling from Notch synaptic complex formation to nuclear entry of the Notch intracellular domain.
PubMed Identifier: 38574735
author list: Tveriakhina L, Scanavachi G, Egan ED, Da Cunha Correia RB, Martin AP, Rogers JM, Yodh JS, Aster JC, Kirchhausen T, Blacklow SC
published in: Developmental cell
information resource reference: Temporal dynamics and stoichiometry in human Notch signaling from Notch synaptic complex formation to nuclear entry of the Notch intracellular domain. Dev Cell. 2024 06 03; 59(11):1425-1438.e8.
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Authorship 156380
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linked information resource: Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling.

Authorship 268171
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linked author: Kirchhausen, Tomas
linked information resource: A low temperature structural transition in human serum low density lipoproteins.

Authorship 333078
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linked information resource: Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly.

Authorship 340590
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linked information resource: Visualizing the high curvature regions of post-mitotic nascent nuclear envelope membrane.

Authorship 343727
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linked author: Kirchhausen, Tomas
linked information resource: Role of the regulatory domain of the EGF-receptor cytoplasmic tail in selective binding of the clathrin-associated complex AP-2.

Authorship 353108
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linked information resource: A putative vacuolar cargo receptor partially colocalizes with AtPEP12p on a prevacuolar compartment in Arabidopsis roots.

Authorship 359444
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linked information resource: T-cell engagement of dendritic cells rapidly rearranges MHC class II transport.

Authorship 1670519
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author rank in publication: 4
linked author: Kirchhausen, Tomas
linked information resource: CryoSamba: self-supervised deep volumetric denoising for cryo-electron tomography data.

CryoSamba: self-supervised deep volumetric denoising for cryo-electron tomography data.
PubMed Identifier: 39071256
author list: Costa-Filho JI, Theveny L, de Sautu M, Kirchhausen T
published in: bioRxiv : the preprint server for biology
information resource reference: CryoSamba: self-supervised deep volumetric denoising for cryo-electron tomography data. bioRxiv. 2024 Aug 03.
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Tutor in Molecular and Cellular Biology
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position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
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Professor of Cell Biology
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Research Fellow in Cell Biology
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position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
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Professor of Pediatrics (Pathology)
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Professor of Pediatrics
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position in division: Community Medicine-PPO
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position in organization: Immune Disease Institute

Research Associate in Pediatrics
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Authorship 453574
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linked information resource: Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.

Authorship 243664
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linked information resource: Mammalian cells change volume during mitosis.

Authorship 310706
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linked information resource: Thermal effects in human plasma high density lipoproteins (HDL)3: a 13C-FT-NMR study.

Authorship 313788
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linked information resource: Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes.

Authorship 644535
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linked author: Kirchhausen, Tomas
linked information resource: Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds.

Authorship 655098
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linked information resource: The small molecule dispergo tubulates the endoplasmic reticulum and inhibits export.

Authorship 654024
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linked information resource: Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation.

Authorship 358168
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linked information resource: Serum low density lipoproteins with mitogenic effect on cultured aortic smooth muscle cells.

The small molecule dispergo tubulates the endoplasmic reticulum and inhibits export.
PubMed Identifier: 23389632
author list: Lu L, Hannoush RN, Goess BC, Varadarajan S, Shair MD, Kirchhausen T
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information resource reference: The small molecule dispergo tubulates the endoplasmic reticulum and inhibits export. Mol Biol Cell. 2013 Apr; 24(7):1020-9.
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Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation.
PubMed Identifier: 23770227
author list: Heesters BA, Chatterjee P, Kim YA, Gonzalez SF, Kuligowski MP, Kirchhausen T, Carroll MC
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information resource reference: Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation. Immunity. 2013 Jun 27; 38(6):1164-75.
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Authorship 79657
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linked author: Kirchhausen, Tomas
linked information resource: Stabilization of clathrin coats by the core of the clathrin-associated protein complex AP-2.

Authorship 1703908
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linked author: Kirchhausen, Tomas
linked information resource: Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling.

Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling.
PubMed Identifier: 39480812
author list: Pascolutti R, Algisi V, Conte A, Raimondi A, Pasham M, Upadhyayula S, Gaudin R, Maritzen T, Barbieri E, Caldieri G, Tordonato C, Confalonieri S, Freddi S, Malabarba MG, Maspero E, Polo S, Tacchetti C, Haucke V, Kirchhausen T, Di Fiore PP, Sigismund S
published in: Cell reports
information resource reference: Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling. Cell Rep. 2024 Nov 26; 43(11):114970.
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Don W. Fawcett Professor of Cell Biology
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HR job title: Don W. Fawcett Professor of Cell Biology
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Hasib Sabbagh Professor of Systems Biology
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HR job title: Hasib Sabbagh Professor of Systems Biology
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Authorship 91378
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linked author: Kirchhausen, Tomas
linked information resource: Crystal structure of the clathrin adaptor protein 1 core.

Neuronal constitutive endolysosomal perforations enable a-synuclein aggregation by internalized PFFs.
PubMed Identifier: 39714357
author list: Sanyal A, Scanavachi G, Somerville E, Saminathan A, Nair A, Bango Da Cunha Correia RF, Aylan B, Sitarska E, Oikonomou A, Hatzakis NS, Kirchhausen T
published in: The Journal of cell biology
information resource reference: Neuronal constitutive endolysosomal perforations enable a-synuclein aggregation by internalized PFFs. J Cell Biol. 2025 Feb 03; 224(2).
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CryoSamba: Self-supervised deep volumetric denoising for cryo-electron tomography data.
PubMed Identifier: 39710216
author list: Costa-Filho JI, Theveny L, de Sautu M, Kirchhausen T
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linked information resource: Neuronal constitutive endolysosomal perforations enable a-synuclein aggregation by internalized PFFs.

Authorship 1720680
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linked information resource: CryoSamba: Self-supervised deep volumetric denoising for cryo-electron tomography data.

Authorship 1725046
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linked information resource: Probing and imaging phospholipid dynamics in live cells.

Probing and imaging phospholipid dynamics in live cells.
PubMed Identifier: 39872507
author list: Wu Z, Du Y, Kirchhausen T, He K
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Authorship 221392
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linked author: Kirchhausen, Tomas
linked information resource: Small molecule-mediated TGF-ß type II receptor degradation promotes cardiomyogenesis in embryonic stem cells.

Authorship 675249
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author rank in publication: 4
linked author: Kirchhausen, Tomas
linked information resource: Live-cell visualization of pre-mRNA splicing with single-molecule sensitivity.

Authorship 678602
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author rank in publication: 4
linked author: Kirchhausen, Tomas
linked information resource: Clathrin-mediated endocytosis persists during unperturbed mitosis.

Clathrin-mediated endocytosis persists during unperturbed mitosis.
PubMed Identifier: 23954786
author list: Tacheva-Grigorova SK, Santos AJ, Boucrot E, Kirchhausen T
published in: Cell reports
information resource reference: Clathrin-mediated endocytosis persists during unperturbed mitosis. Cell Rep. 2013 Aug 29; 4(4):659-68.
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Live-cell visualization of pre-mRNA splicing with single-molecule sensitivity.
PubMed Identifier: 24035393
author list: Martin RM, Rino J, Carvalho C, Kirchhausen T, Carmo-Fonseca M
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information resource reference: Live-cell visualization of pre-mRNA splicing with single-molecule sensitivity. Cell Rep. 2013 Sep 26; 4(6):1144-55.
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Authorship 679925
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linked author: Kirchhausen, Tomas
linked information resource: Uptake of rabies virus into epithelial cells by clathrin-mediated endocytosis depends upon actin.

Uptake of rabies virus into epithelial cells by clathrin-mediated endocytosis depends upon actin.
PubMed Identifier: 23966407
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Deep learning-assisted analysis of single-particle tracking for automated correlation between diffusion and function.
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Authorship 198472
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Molecular structure, function, and dynamics of clathrin-mediated membrane traffic.
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Key interactions for clathrin coat stability.
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Tau seeding in neurons enabled by transient endolysosomal perforations are confined within endolysosomes.
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SpatialDINO: A Self-Supervised 3D Vision Transformer that enables Segmentation and Tracking in Crowded Cellular Environments.
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Authorship 331252
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Authorship 401943
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Authorship 309795
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Authorship 403388
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Authorship 526002
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Authorship 540677
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linked information resource: Mechanisms of signal-mediated protein sorting in the endocytic and secretory pathways.

Authorship 541804
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linked information resource: Possible role of deep tubular invaginations of the plasma membrane in MHC-I trafficking.

Authorship 756479
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Structural correlates of rotavirus cell entry.
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Authorship 559127
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Authorship 561763
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Authorship 758144
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linked information resource: In vivo analysis of formation and endocytosis of the Wnt/ß-catenin signaling complex in zebrafish embryos.

In vivo analysis of formation and endocytosis of the Wnt/ß-catenin signaling complex in zebrafish embryos.
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Authorship 71182
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Authorship 89046
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Authorship 768770
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linked information resource: Dynamin recruitment and membrane scission at the neck of a clathrin-coated pit.

Dynamin recruitment and membrane scission at the neck of a clathrin-coated pit.
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Authorship 468231
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Authorship 776577
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linked information resource: In vivo analysis of formation and endocytosis of the Wnt/ß-Catenin signaling complex in zebrafish embryos.

In vivo analysis of formation and endocytosis of the Wnt/ß-Catenin signaling complex in zebrafish embryos.
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Authorship 5111
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linked information resource: The Saccharomyces cerevisiae APS1 gene encodes a homolog of the small subunit of the mammalian clathrin AP-1 complex: evidence for functional interaction with clathrin at the Golgi complex.

Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology.
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Authorship 301329
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Authorship 393880
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Authorship 396993
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Authorship 59645
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Cellular and Molecular Medicine
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Authorship 63833
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Authorship 64225
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Authorship 417567
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Authorship 435650
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Authorship 271194
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Authorship 535035
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Authorship 289650
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Authorship 457721
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Authorship 489243
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Authorship 52894
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Authorship 289888
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Authorship 45811
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Authorship 322944
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Authorship 514585
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linked information resource: A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating.

Authorship 800393
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linked information resource: Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology.

Authorship 806319
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linked information resource: Asymmetric formation of coated pits on dorsal and ventral surfaces at the leading edges of motile cells and on protrusions of immobile cells.

Asymmetric formation of coated pits on dorsal and ventral surfaces at the leading edges of motile cells and on protrusions of immobile cells.
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author list: Kural C, Akatay AA, Gaudin R, Chen BC, Legant WR, Betzig E, Kirchhausen T
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Authorship 337585
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Authorship 320216
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Authorship 498162
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linked information resource: Shiga toxin increases formation of clathrin-coated pits through Syk kinase.

Authorship 521212
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linked author: Kirchhausen, Tomas
linked information resource: Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments.

Authorship 524119
type: Authorship
author rank in publication: 2
linked author: Kirchhausen, Tomas
linked information resource: Structure determination of clathrin coats to subnanometer resolution by single particle cryo-electron microscopy.

Authorship 529513
type: Authorship
author rank in publication: 1
linked author: Kirchhausen, Tomas
linked information resource: Disease mechanism: unravelling Wiskott-Aldrich syndrome.

Authorship 540797
type: Authorship
author rank in publication: 6
linked author: Kirchhausen, Tomas
linked information resource: The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation.

Authorship 542916
type: Authorship
author rank in publication: 3
linked author: Kirchhausen, Tomas
linked information resource: Interaction of the bovine papillomavirus E6 protein with the clathrin adaptor complex AP-1.

Authorship 375063
type: Authorship
author rank in publication: 4
linked author: Kirchhausen, Tomas
linked information resource: Role of lipids and actin in the formation of clathrin-coated pits.

Authorship 824541
type: Authorship
author rank in publication: 8
linked author: Kirchhausen, Tomas
linked information resource: Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown.

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown.
PubMed Identifier: 26192320
author list: Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, Lieberman J
published in: Nature biotechnology
information resource reference: Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown. Nat Biotechnol. 2015 Aug; 33(8):870-6.
journal title abbreviation: Nat Biotechnol
publication date: 2015-07-20T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 831368
type: Authorship
author rank in publication: 11
linked author: Kirchhausen, Tomas
linked information resource: ADVANCED IMAGING. Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics.

ADVANCED IMAGING. Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics.
PubMed Identifier: 26315442
author list: Li D, Shao L, Chen BC, Zhang X, Zhang M, Moses B, Milkie DE, Beach JR, Hammer JA, Pasham M, Kirchhausen T, Baird MA, Davidson MW, Xu P, Betzig E
published in: Science (New York, N.Y.)
information resource reference: ADVANCED IMAGING. Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics. Science. 2015 Aug 28; 349(6251):aab3500.
journal title abbreviation: Science
publication date: 2015-08-28T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 72664
type: Authorship
author rank in publication: 4
linked author: Kirchhausen, Tomas
linked information resource: Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker.

Authorship 442575
type: Authorship
author rank in publication: 7
linked author: Kirchhausen, Tomas
linked information resource: The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes.

Authorship 447097
type: Authorship
author rank in publication: 4
linked author: Kirchhausen, Tomas
linked information resource: Effects of dynamin inactivation on pathways of anthrax toxin uptake.

Superinfection exclusion is absent during acute Junin virus infection of Vero and A549 cells.
PubMed Identifier: 26549784
author list: Gaudin R, Kirchhausen T
published in: Scientific reports
information resource reference: Superinfection exclusion is absent during acute Junin virus infection of Vero and A549 cells. Sci Rep. 2015 Nov 09; 5:15990.
journal title abbreviation: Sci Rep
publication date: 2015-11-09T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 483614
type: Authorship
author rank in publication: 6
linked author: Kirchhausen, Tomas
linked information resource: The Cdc42 inhibitor secramine B prevents cAMP-induced K+ conductance in intestinal epithelial cells.

Authorship 847294
type: Authorship
author rank in publication: 2
linked author: Kirchhausen, Tomas
linked information resource: Superinfection exclusion is absent during acute Junin virus infection of Vero and A549 cells.

Authorship 853536
type: Authorship
author rank in publication: 3
linked author: Kirchhausen, Tomas
linked information resource: Endocytosis of Ligand-Activated Sphingosine 1-Phosphate Receptor 1 Mediated by the Clathrin-Pathway.

Endocytosis of Ligand-Activated Sphingosine 1-Phosphate Receptor 1 Mediated by the Clathrin-Pathway.
PubMed Identifier: 26481905
author list: Reeves PM, Kang YL, Kirchhausen T
published in: Traffic (Copenhagen, Denmark)
information resource reference: Endocytosis of Ligand-Activated Sphingosine 1-Phosphate Receptor 1 Mediated by the Clathrin-Pathway. Traffic. 2016 Jan; 17(1):40-52.
journal title abbreviation: Traffic
publication date: 2015-12-09T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Secramine: Specificity and Inhibition of Cell Transformation
end date: 2005-08-19T00:00:00
start date: 2005-06-27T00:00:00
type: Mentoring - Completed Student Project
overview: Summer

Authorship 868189
type: Authorship
author rank in publication: 67
linked author: Kirchhausen, Tomas
linked information resource: Data publication with the structural biology data grid supports live analysis.

Data publication with the structural biology data grid supports live analysis.
PubMed Identifier: 26947396
author list: Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P
published in: Nature communications
information resource reference: Data publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 07; 7:10882.
journal title abbreviation: Nat Commun
publication date: 2016-03-07T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 31576
type: Authorship
author rank in publication: 2
linked author: Kirchhausen, Tomas
linked information resource: Endosomal recycling controls plasma membrane area during mitosis.

Authorship 384068
type: Authorship
author rank in publication: 4
linked author: Kirchhausen, Tomas
linked information resource: Stoichiometric interaction of the epidermal growth factor receptor with the clathrin-associated protein complex AP-2.

Authorship 876303
type: Authorship
author rank in publication: 13
linked author: Kirchhausen, Tomas
linked information resource: Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor.

Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor.
PubMed Identifier: 26912630
author list: Chou YY, Cuevas C, Carocci M, Stubbs SH, Ma M, Cureton DK, Chao L, Evesson F, He K, Yang PL, Whelan SP, Ross SR, Kirchhausen T, Gaudin R
published in: Journal of virology
information resource reference: Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor. J Virol. 2016 May; 90(9):4494-4510.
journal title abbreviation: J Virol
publication date: 2016-04-14T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 508381
type: Authorship
author rank in publication: 12
linked author: Kirchhausen, Tomas
linked information resource: ARFGAP1 promotes AP-2-dependent endocytosis.

Authorship 53399
type: Authorship
author rank in publication: 2
linked author: Kirchhausen, Tomas
linked information resource: The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components.

Authorship 68533
type: Authorship
author rank in publication: 5
linked author: Kirchhausen, Tomas
linked information resource: Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site.

Authorship 85447
type: Authorship
author rank in publication: 4
linked author: Kirchhausen, Tomas
linked information resource: HIV Nef-mediated major histocompatibility complex class I down-modulation is independent of Arf6 activity.

Fellow or Post Doc
sort order: 6
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Lecturer
sort order: 3
type: Faculty Rank

Other Faculty
sort order: 5
type: Faculty Rank

Authorship 59259
type: Authorship
author rank in publication: 4
linked author: Kirchhausen, Tomas
linked information resource: The first five seconds in the life of a clathrin-coated pit.

Authorship 544072
type: Authorship
author rank in publication: 5
linked author: Kirchhausen, Tomas
linked information resource: Functional organization of clathrin in coats: combining electron cryomicroscopy and X-ray crystallography.

Authorship 72628
type: Authorship
author rank in publication: 2
linked author: Kirchhausen, Tomas
linked information resource: Small-angle x-ray scattering study of human serum low-density lipoproteins with differential reactivity for an arterial proteoglycan.

Authorship 95460
type: Authorship
author rank in publication: 4
linked author: Kirchhausen, Tomas
linked information resource: The length of vesicular stomatitis virus particles dictates a need for actin assembly during clathrin-dependent endocytosis.

New England Regional Center of Excellence in Biodefense and Emerging Infectious D
end date: 2015-02-28
principal investigator name: KASPER, DENNIS L.
start date: 2003-09-04
type: Grant
sponsor award id: U54AI057159

Dynamics of Clathrin Coat Formation in Cells
end date: 2019-03-31
principal investigator name: KIRCHHAUSEN, TOMAS
start date: 2005-09-10
type: Grant
sponsor award id: R01GM075252

CHEMICAL GENETIC APPROACHES TO BASIC CELL BIOLOGY
end date: 2006-08-31
principal investigator name: MITCHISON, TIMOTHY J
start date: 2000-09-30
type: Grant
sponsor award id: P01GM062566

MECHANISM OF MHC CLASS I DOWN-REGULATION BY HIV NEF
end date: 2003-02-28
principal investigator name: KIRCHHAUSEN, TOMAS
start date: 2000-03-01
type: Grant
sponsor award id: R21GM060357

Molecular Interactions in Clathrin Coated Vesicles
end date: 2016-06-30
principal investigator name: KIRCHHAUSEN, TOMAS
start date: 1986-04-01
type: Grant
sponsor award id: R01GM036548

Small molecule inhibitors of enveloped virus entry
end date: 2019-02-28
principal investigator name: WHELAN, SEAN PJ
start date: 2014-03-01
type: Grant
sponsor award id: U19AI109740

Principal Investigator
type: Researcher Role
researcher role of: Kirchhausen, Tomas
contributes to: MECHANISM OF MHC CLASS I DOWN-REGULATION BY HIV NEF

Co-Principal Investigator
type: Researcher Role
researcher role of: Kirchhausen, Tomas
contributes to: New England Regional Center of Excellence in Biodefense and Emerging Infectious D

Principal Investigator
type: Researcher Role
researcher role of: Kirchhausen, Tomas
contributes to: Dynamics of Clathrin Coat Formation in Cells

Co-Principal Investigator
type: Researcher Role
researcher role of: Kirchhausen, Tomas
contributes to: Small molecule inhibitors of enveloped virus entry

Co-Principal Investigator
type: Researcher Role
researcher role of: Kirchhausen, Tomas
contributes to: CHEMICAL GENETIC APPROACHES TO BASIC CELL BIOLOGY

Principal Investigator
type: Researcher Role
researcher role of: Kirchhausen, Tomas
contributes to: Molecular Interactions in Clathrin Coated Vesicles

Authorship 86863
type: Authorship
author rank in publication: 3
linked author: Kirchhausen, Tomas
linked information resource: Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin.

Authorship 439169
type: Authorship
author rank in publication: 1
linked author: Kirchhausen, Tomas
linked information resource: Single-molecule live-cell imaging of clathrin-based endocytosis.

Authorship 472509
type: Authorship
author rank in publication: 4
linked author: Kirchhausen, Tomas
linked information resource: A role for the hinge/ear domain of the beta chains in the incorporation of AP complexes into clathrin-coated pits and coated vesicles.

Authorship 484578
type: Authorship
author rank in publication: 1
linked author: Kirchhausen, Tomas
linked information resource: Three ways to make a vesicle.

Authorship 936148
type: Authorship
author rank in publication: 7
linked author: Kirchhausen, Tomas
linked information resource: Inhibition of JCPyV infection mediated by targeted viral genome editing using CRISPR/Cas9.

Authorship 931024
type: Authorship
author rank in publication: 11
linked author: Kirchhausen, Tomas
linked information resource: Membrane fission by dynamin: what we know and what we need to know.

Authorship 933263
type: Authorship
author rank in publication: 18
linked author: Kirchhausen, Tomas
linked information resource: Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy.

Authorship 934489
type: Authorship
author rank in publication: 7
linked author: Kirchhausen, Tomas
linked information resource: Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion.

Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy.
PubMed Identifier: 27535432
author list: Aguet F, Upadhyayula S, Gaudin R, Chou YY, Cocucci E, He K, Chen BC, Mosaliganti K, Pasham M, Skillern W, Legant WR, Liu TL, Findlay G, Marino E, Danuser G, Megason S, Betzig E, Kirchhausen T
published in: Molecular biology of the cell
information resource reference: Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy. Mol Biol Cell. 2016 11 07; 27(22):3418-3435.
journal title abbreviation: Mol Biol Cell
publication date: 2016-08-17T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhibition of JCPyV infection mediated by targeted viral genome editing using CRISPR/Cas9.
PubMed Identifier: 27841295
author list: Chou YY, Krupp A, Kaynor C, Gaudin R, Ma M, Cahir-McFarland E, Kirchhausen T
published in: Scientific reports
information resource reference: Inhibition of JCPyV infection mediated by targeted viral genome editing using CRISPR/Cas9. Sci Rep. 2016 Nov 14; 6:36921.
journal title abbreviation: Sci Rep
publication date: 2016-11-14T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion.
PubMed Identifier: 27810927
author list: Hu Y, Kim JH, He K, Wan Q, Kim J, Flach M, Kirchhausen T, Vortkamp A, Winau F
published in: The Journal of experimental medicine
information resource reference: Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion. J Exp Med. 2016 11 14; 213(12):2759-2772.
journal title abbreviation: J Exp Med
publication date: 2016-10-24T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Membrane fission by dynamin: what we know and what we need to know.
PubMed Identifier: 27670760
author list: Antonny B, Burd C, De Camilli P, Chen E, Daumke O, Faelber K, Ford M, Frolov VA, Frost A, Hinshaw JE, Kirchhausen T, Kozlov MM, Lenz M, Low HH, McMahon H, Merrifield C, Pollard TD, Robinson PJ, Roux A, Schmid S
published in: The EMBO journal
information resource reference: Membrane fission by dynamin: what we know and what we need to know. EMBO J. 2016 11 02; 35(21):2270-2284.
journal title abbreviation: EMBO J
publication date: 2016-09-26T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 67189
type: Authorship
author rank in publication: 5
linked author: Kirchhausen, Tomas
linked information resource: Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI.

Authorship 69365
type: Authorship
author rank in publication: 3
linked author: Kirchhausen, Tomas
linked information resource: Redistribution of caveolae during mitosis.

Authorship 244090
type: Authorship
author rank in publication: 4
linked author: Kirchhausen, Tomas
linked information resource: Identification of Itk/Tsk Src homology 3 domain ligands.

Authorship 282172
type: Authorship
author rank in publication: 5
linked author: Kirchhausen, Tomas
linked information resource: Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis.

Authorship 283452
type: Authorship
author rank in publication: 7
linked author: Kirchhausen, Tomas
linked information resource: Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi.

Authorship 393698
type: Authorship
author rank in publication: 5
linked author: Kirchhausen, Tomas
linked information resource: The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly.

Authorship 58495
type: Authorship
author rank in publication: 9
linked author: Kirchhausen, Tomas
linked information resource: Molecular cloning and complete amino acid sequence of AP50, an assembly protein associated with clathrin-coated vesicles.

Authorship 76874
type: Authorship
author rank in publication: 7
linked author: Kirchhausen, Tomas
linked information resource: Similar uptake but different trafficking and escape routes of reovirus virions and infectious subvirion particles imaged in polarized Madin-Darby canine kidney cells.

Authorship 958441
type: Authorship
author rank in publication: 18
linked author: Kirchhausen, Tomas
linked information resource: Seipin is required for converting nascent to mature lipid droplets.

Seipin is required for converting nascent to mature lipid droplets.
PubMed Identifier: 27564575
author list: Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, Upadhyayula S, Perrimon N, Kirchhausen T, Ejsing CS, Walther TC, Farese RV
published in: eLife
information resource reference: Seipin is required for converting nascent to mature lipid droplets. Elife. 2016 Aug 26; 5.
journal title abbreviation: Elife
publication date: 2016-08-26T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Disease mechanism: unravelling Wiskott-Aldrich syndrome.
PubMed Identifier: 8793292
author list: Kirchhausen T, Rosen FS
published in: Current biology : CB
information resource reference: Disease mechanism: unravelling Wiskott-Aldrich syndrome. Curr Biol. 1996 Jun 01; 6(6):676-8.
journal title abbreviation: Curr Biol
publication date: 1996-06-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of Itk/Tsk Src homology 3 domain ligands.
PubMed Identifier: 8810341
author list: Bunnell SC, Henry PA, Kolluri R, Kirchhausen T, Rickles RJ, Berg LJ
published in: The Journal of biological chemistry
information resource reference: Identification of Itk/Tsk Src homology 3 domain ligands. J Biol Chem. 1996 Oct 11; 271(41):25646-56.
journal title abbreviation: J Biol Chem
publication date: 1996-10-11T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Mechanisms of signal-mediated protein sorting in the endocytic and secretory pathways.
PubMed Identifier: 8863342
author list: Bonifacino JS, Marks MS, Ohno H, Kirchhausen T
published in: Proceedings of the Association of American Physicians
information resource reference: Mechanisms of signal-mediated protein sorting in the endocytic and secretory pathways. Proc Assoc Am Physicians. 1996 Jul; 108(4):285-95.
journal title abbreviation: Proc Assoc Am Physicians
publication date: 1996-07-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro.
PubMed Identifier: 8868465
author list: Spiro DJ, Boll W, Kirchhausen T, Wessling-Resnick M
published in: Molecular biology of the cell
information resource reference: Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro. Mol Biol Cell. 1996 Mar; 7(3):355-67.
journal title abbreviation: Mol Biol Cell
publication date: 1996-03-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

A putative vacuolar cargo receptor partially colocalizes with AtPEP12p on a prevacuolar compartment in Arabidopsis roots.
PubMed Identifier: 9707576
author list: Sanderfoot AA, Ahmed SU, Marty-Mazars D, Rapoport I, Kirchhausen T, Marty F, Raikhel NV
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: A putative vacuolar cargo receptor partially colocalizes with AtPEP12p on a prevacuolar compartment in Arabidopsis roots. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):9920-5.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1998-08-18T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability.
PubMed Identifier: 10898977
author list: Chen F, Ma L, Parrini MC, Mao X, Lopez M, Wu C, Marks PW, Davidson L, Kwiatkowski DJ, Kirchhausen T, Orkin SH, Rosen FS, Mayer BJ, Kirschner MW, Alt FW
published in: Current biology : CB
information resource reference: Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Curr Biol. 2000 Jun 29; 10(13):758-65.
journal title abbreviation: Curr Biol
publication date: 2000-06-29T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppØ sorting signals at distinct sites.
PubMed Identifier: 12121421
author list: Boll W, Rapoport I, Brunner C, Modis Y, Prehn S, Kirchhausen T
published in: Traffic (Copenhagen, Denmark)
information resource reference: The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppØ sorting signals at distinct sites. Traffic. 2002 Aug; 3(8):590-600.
journal title abbreviation: Traffic
publication date: 2002-08-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI.
PubMed Identifier: 12438696
author list: Nieland TJ, Penman M, Dori L, Krieger M, Kirchhausen T
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15422-7.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2002-11-18T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

The delta region of outer-capsid protein micro 1 undergoes conformational change and release from reovirus particles during cell entry.
PubMed Identifier: 14645591
author list: Chandran K, Parker JS, Ehrlich M, Kirchhausen T, Nibert ML
published in: Journal of virology
information resource reference: The delta region of outer-capsid protein micro 1 undergoes conformational change and release from reovirus particles during cell entry. J Virol. 2003 Dec; 77(24):13361-75.
journal title abbreviation: J Virol
publication date: 2003-12-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site.
PubMed Identifier: 9545228
author list: Rapoport I, Chen YC, Cupers P, Shoelson SE, Kirchhausen T
published in: The EMBO journal
information resource reference: Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site. EMBO J. 1998 Apr 15; 17(8):2148-55.
journal title abbreviation: EMBO J
publication date: 1998-04-15T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular model for a complete clathrin lattice from electron cryomicroscopy.
PubMed Identifier: 15502812
author list: Fotin A, Cheng Y, Sliz P, Grigorieff N, Harrison SC, Kirchhausen T, Walz T
published in: Nature
information resource reference: Molecular model for a complete clathrin lattice from electron cryomicroscopy. Nature. 2004 Dec 02; 432(7017):573-9.
journal title abbreviation: Nature
publication date: 2004-10-24T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Kinetics of thermal transitions in human serum low density lipoproteins (LDL) and neutral lipids. A dynamic small-angle X-ray scattering study.
PubMed Identifier: 232603
author list: Mateu L, Kirchhausen T
published in: Acta cientifica venezolana
information resource reference: Kinetics of thermal transitions in human serum low density lipoproteins (LDL) and neutral lipids. A dynamic small-angle X-ray scattering study. Acta Cient Venez. 1979; 30(5):478-83.
journal title abbreviation: Acta Cient Venez
publication date: 1979-01-01T00:00:00
year: 1979
type: Academic Article
type: Article
type: Document
type: Information Resource

L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1.
PubMed Identifier: 12082080
author list: Schaefer AW, Kamei Y, Kamiguchi H, Wong EV, Rapoport I, Kirchhausen T, Beach CM, Landreth G, Lemmon SK, Lemmon V
published in: The Journal of cell biology
information resource reference: L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1. J Cell Biol. 2002 Jun 24; 157(7):1223-32.
journal title abbreviation: J Cell Biol
publication date: 2002-06-24T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Chemical genetic screening identifies sulfonamides that raise organellar pH and interfere with membrane traffic.
PubMed Identifier: 15180825
author list: Nieland TJ, Feng Y, Brown JX, Chuang TD, Buckett PD, Wang J, Xie XS, McGraw TE, Kirchhausen T, Wessling-Resnick M
published in: Traffic (Copenhagen, Denmark)
information resource reference: Chemical genetic screening identifies sulfonamides that raise organellar pH and interfere with membrane traffic. Traffic. 2004 Jul; 5(7):478-92.
journal title abbreviation: Traffic
publication date: 2004-07-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Endocytosis by random initiation and stabilization of clathrin-coated pits.
PubMed Identifier: 15339664
author list: Ehrlich M, Boll W, Van Oijen A, Hariharan R, Chandran K, Nibert ML, Kirchhausen T
published in: Cell
information resource reference: Endocytosis by random initiation and stabilization of clathrin-coated pits. Cell. 2004 Sep 03; 118(5):591-605.
journal title abbreviation: Cell
publication date: 2004-09-03T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast.
PubMed Identifier: 2040623
author list: Kirchhausen T, Davis AC, Frucht S, Greco BO, Payne GS, Tubb B
published in: The Journal of biological chemistry
information resource reference: AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. J Biol Chem. 1991 Jun 15; 266(17):11153-7.
journal title abbreviation: J Biol Chem
publication date: 1991-06-15T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Dynasore, a cell-permeable inhibitor of dynamin.
PubMed Identifier: 16740485
author list: Macia E, Ehrlich M, Massol R, Boucrot E, Brunner C, Kirchhausen T
published in: Developmental cell
information resource reference: Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell. 2006 Jun; 10(6):839-50.
journal title abbreviation: Dev Cell
publication date: 2006-06-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly.
PubMed Identifier: 17095010
author list: Cheng Y, Boll W, Kirchhausen T, Harrison SC, Walz T
published in: Journal of molecular biology
information resource reference: Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly. J Mol Biol. 2007 Jan 19; 365(3):892-9.
journal title abbreviation: J Mol Biol
publication date: 2006-10-14T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation.
PubMed Identifier: 17261583
author list: Ma YM, Boucrot E, Villén J, Affar EB, Gygi SP, Göttlinger HG, Kirchhausen T
published in: The Journal of biological chemistry
information resource reference: Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation. J Biol Chem. 2007 Mar 30; 282(13):9805-9812.
journal title abbreviation: J Biol Chem
publication date: 2007-01-29T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits.
PubMed Identifier: 8910509
author list: Tebar F, Sorkina T, Sorkin A, Ericsson M, Kirchhausen T
published in: The Journal of biological chemistry
information resource reference: Eps15 is a component of clathrin-coated pits and vesicles and is located at the rim of coated pits. J Biol Chem. 1996 Nov 15; 271(46):28727-30.
journal title abbreviation: J Biol Chem
publication date: 1996-11-15T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes.
PubMed Identifier: 9171339
author list: Rapoport I, Miyazaki M, Boll W, Duckworth B, Cantley LC, Shoelson S, Kirchhausen T
published in: The EMBO journal
information resource reference: Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes. EMBO J. 1997 May 01; 16(9):2240-50.
journal title abbreviation: EMBO J
publication date: 1997-05-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4.
PubMed Identifier: 9811611
author list: Greenberg M, DeTulleo L, Rapoport I, Skowronski J, Kirchhausen T
published in: Current biology : CB
information resource reference: A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4. Curr Biol. 1998 Nov 05; 8(22):1239-42.
journal title abbreviation: Curr Biol
publication date: 1998-11-05T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Clathrin adaptors really adapt.
PubMed Identifier: 12086597
author list: Kirchhausen T
published in: Cell
information resource reference: Clathrin adaptors really adapt. Cell. 2002 May 17; 109(4):413-6.
journal title abbreviation: Cell
publication date: 2002-05-17T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Functional organization of clathrin in coats: combining electron cryomicroscopy and X-ray crystallography.
PubMed Identifier: 10394364
author list: Musacchio A, Smith CJ, Roseman AM, Harrison SC, Kirchhausen T, Pearse BM
published in: Molecular cell
information resource reference: Functional organization of clathrin in coats: combining electron cryomicroscopy and X-ray crystallography. Mol Cell. 1999 Jun; 3(6):761-70.
journal title abbreviation: Mol Cell
publication date: 1999-06-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

200 Longwood Ave
type: Address
address line 1: Harvard Medical School
address line 2: PCMM, Warren Alpert Building, Rm 133B
address line 3: 200 Longwood Ave
city: Boston
postal code: 02115
state or province: MA

Cell biology. Boa constrictor or rattlesnake?
PubMed Identifier: 10206640
author list: Kirchhausen T
published in: Nature
information resource reference: Cell biology. Boa constrictor or rattlesnake? Nature. 1999 Apr 08; 398(6727):470-1.
journal title abbreviation: Nature
publication date: 1999-04-08T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes.
PubMed Identifier: 8918456
author list: Boll W, Ohno H, Songyang Z, Rapoport I, Cantley LC, Bonifacino JS, Kirchhausen T
published in: The EMBO journal
information resource reference: Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes. EMBO J. 1996 Nov 01; 15(21):5789-95.
journal title abbreviation: EMBO J
publication date: 1996-11-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker.
PubMed Identifier: 9827808
author list: ter Haar E, Musacchio A, Harrison SC, Kirchhausen T
published in: Cell
information resource reference: Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker. Cell. 1998 Nov 13; 95(4):563-73.
journal title abbreviation: Cell
publication date: 1998-11-13T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

The medium chains of the mammalian clathrin-associated proteins have a homolog in yeast.
PubMed Identifier: 1761056
author list: Nakayama Y, Goebl M, O'Brine Greco B, Lemmon S, Pingchang Chow E, Kirchhausen T
published in: European journal of biochemistry
information resource reference: The medium chains of the mammalian clathrin-associated proteins have a homolog in yeast. Eur J Biochem. 1991 Dec 05; 202(2):569-74.
journal title abbreviation: Eur J Biochem
publication date: 1991-12-05T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

Crystal structure of the clathrin adaptor protein 1 core.
PubMed Identifier: 15377783
author list: Heldwein EE, Macia E, Wang J, Yin HL, Kirchhausen T, Harrison SC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Crystal structure of the clathrin adaptor protein 1 core. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14108-13.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2004-09-17T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis.
PubMed Identifier: 16169498
author list: Keefe D, Shi L, Feske S, Massol R, Navarro F, Kirchhausen T, Lieberman J
published in: Immunity
information resource reference: Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis. Immunity. 2005 Sep; 23(3):249-62.
journal title abbreviation: Immunity
publication date: 2005-09-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Exo1: a new chemical inhibitor of the exocytic pathway.
PubMed Identifier: 12738886
author list: Feng Y, Yu S, Lasell TK, Jadhav AP, Macia E, Chardin P, Melancon P, Roth M, Mitchison T, Kirchhausen T
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Exo1: a new chemical inhibitor of the exocytic pathway. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6469-74.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2003-05-08T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Multivalent binding of nonnative substrate proteins by the chaperonin GroEL.
PubMed Identifier: 10721993
author list: Farr GW, Furtak K, Rowland MB, Ranson NA, Saibil HR, Kirchhausen T, Horwich AL
published in: Cell
information resource reference: Multivalent binding of nonnative substrate proteins by the chaperonin GroEL. Cell. 2000 Mar 03; 100(5):561-73.
journal title abbreviation: Cell
publication date: 2000-03-03T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation.
PubMed Identifier: 18974134
author list: Ambrogio C, Voena C, Manazza AD, Martinengo C, Costa C, Kirchhausen T, Hirsch E, Inghirami G, Chiarle R
published in: Cancer research
information resource reference: The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation. Cancer Res. 2008 Nov 01; 68(21):8899-907.
journal title abbreviation: Cancer Res
publication date: 2008-11-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Recruitment of cellular clathrin to viral factories and disruption of clathrin-dependent trafficking.
PubMed Identifier: 21736684
author list: Ivanovic T, Boulant S, Ehrlich M, Demidenko AA, Arnold MM, Kirchhausen T, Nibert ML
published in: Traffic (Copenhagen, Denmark)
information resource reference: Recruitment of cellular clathrin to viral factories and disruption of clathrin-dependent trafficking. Traffic. 2011 Sep; 12(9):1179-95.
journal title abbreviation: Traffic
publication date: 2011-07-07T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

A low temperature structural transition in human serum low density lipoproteins.
PubMed Identifier: 192306
author list: Mateu L, Kirchhausen T, Camejo G
published in: Biochimica et biophysica acta
information resource reference: A low temperature structural transition in human serum low density lipoproteins. Biochim Biophys Acta. 1977 Apr 26; 487(1):243-5.
journal title abbreviation: Biochim Biophys Acta
publication date: 1977-04-26T00:00:00
year: 1977
type: Academic Article
type: Article
type: Document
type: Information Resource

Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide.
PubMed Identifier: 15102890
author list: Nieland TJ, Chroni A, Fitzgerald ML, Maliga Z, Zannis VI, Kirchhausen T, Krieger M
published in: Journal of lipid research
information resource reference: Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide. J Lipid Res. 2004 Jul; 45(7):1256-65.
journal title abbreviation: J Lipid Res
publication date: 2004-04-21T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Single-molecule live-cell imaging of clathrin-based endocytosis.
PubMed Identifier: 15649131
author list: Kirchhausen T, Boll W, van Oijen A, Ehrlich M
published in: Biochemical Society symposium
information resource reference: Single-molecule live-cell imaging of clathrin-based endocytosis. Biochem Soc Symp. 2005; (72):71-6.
journal title abbreviation: Biochem Soc Symp
publication date: 2005-01-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Linking cargo to vesicle formation: receptor tail interactions with coat proteins.
PubMed Identifier: 9261055
author list: Kirchhausen T, Bonifacino JS, Riezman H
published in: Current opinion in cell biology
information resource reference: Linking cargo to vesicle formation: receptor tail interactions with coat proteins. Curr Opin Cell Biol. 1997 Aug; 9(4):488-95.
journal title abbreviation: Curr Opin Cell Biol
publication date: 1997-08-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal.
PubMed Identifier: 22162134
author list: Hori K, Sen A, Kirchhausen T, Artavanis-Tsakonas S
published in: The Journal of cell biology
information resource reference: Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal. J Cell Biol. 2011 Dec 12; 195(6):1005-15.
journal title abbreviation: J Cell Biol
publication date: 2011-12-12T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Vesicle formation: dynamic dynamin lives up to its name.
PubMed Identifier: 9811595
author list: Kirchhausen T
published in: Current biology : CB
information resource reference: Vesicle formation: dynamic dynamin lives up to its name. Curr Biol. 1998 Nov 05; 8(22):R792-4.
journal title abbreviation: Curr Biol
publication date: 1998-11-05T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Small-angle X-ray scattering and differential scanning calorimetry studies on reversibly modified human-serum low density lipoproteins.
PubMed Identifier: 206277
author list: Mateu L, Kirchhausen T, Camejo G
published in: Biochemistry
information resource reference: Small-angle X-ray scattering and differential scanning calorimetry studies on reversibly modified human-serum low density lipoproteins. Biochemistry. 1978 Apr 18; 17(8):1436-40.
journal title abbreviation: Biochemistry
publication date: 1978-04-18T00:00:00
year: 1978
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 988914
type: Authorship
author rank in publication: 6
linked author: Kirchhausen, Tomas
linked information resource: Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration.

Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration.
PubMed Identifier: 28615318
author list: Schuler MH, Lewandowska A, Caprio GD, Skillern W, Upadhyayula S, Kirchhausen T, Shaw JM, Cunniff B
published in: Molecular biology of the cell
information resource reference: Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration. Mol Biol Cell. 2017 Aug 01; 28(16):2159-2169.
journal title abbreviation: Mol Biol Cell
publication date: 2017-06-14T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Differential evanescence nanometry: live-cell fluorescence measurements with 10-nm axial resolution on the plasma membrane.
PubMed Identifier: 17993495
author list: Saffarian S, Kirchhausen T
published in: Biophysical journal
information resource reference: Differential evanescence nanometry: live-cell fluorescence measurements with 10-nm axial resolution on the plasma membrane. Biophys J. 2008 Mar 15; 94(6):2333-42.
journal title abbreviation: Biophys J
publication date: 2007-11-09T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization.
PubMed Identifier: 19390604
author list: Cureton DK, Massol RH, Saffarian S, Kirchhausen TL, Whelan SP
published in: PLoS pathogens
information resource reference: Vesicular stomatitis virus enters cells through vesicles incompletely coated with clathrin that depend upon actin for internalization. PLoS Pathog. 2009 Apr; 5(4):e1000394.
journal title abbreviation: PLoS Pathog
publication date: 2009-04-24T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Small molecule-mediated TGF-ß type II receptor degradation promotes cardiomyogenesis in embryonic stem cells.
PubMed Identifier: 22862949
author list: Willems E, Cabral-Teixeira J, Schade D, Cai W, Reeves P, Bushway PJ, Lanier M, Walsh C, Kirchhausen T, Izpisua Belmonte JC, Cashman J, Mercola M
published in: Cell stem cell
information resource reference: Small molecule-mediated TGF-ß type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012 Aug 03; 11(2):242-52.
journal title abbreviation: Cell Stem Cell
publication date: 2012-08-03T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Structural biology: Conservation in vesicle coats.
PubMed Identifier: 20739998
author list: Harrison SC, Kirchhausen T
published in: Nature
information resource reference: Structural biology: Conservation in vesicle coats. Nature. 2010 Aug 26; 466(7310):1048-9.
journal title abbreviation: Nature
publication date: 2010-08-26T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing.
PubMed Identifier: 15332114
author list: Cerny J, Feng Y, Yu A, Miyake K, Borgonovo B, Klumperman J, Meldolesi J, McNeil PL, Kirchhausen T
published in: EMBO reports
information resource reference: The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing. EMBO Rep. 2004 Sep; 5(9):883-8.
journal title abbreviation: EMBO Rep
publication date: 2004-09-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

An emergency response team for membrane repair.
PubMed Identifier: 15928713
author list: McNeil PL, Kirchhausen T
published in: Nature reviews. Molecular cell biology
information resource reference: An emergency response team for membrane repair. Nat Rev Mol Cell Biol. 2005 Jun; 6(6):499-505.
journal title abbreviation: Nat Rev Mol Cell Biol
publication date: 2005-06-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Clathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs.
PubMed Identifier: 3563513
author list: Kirchhausen T, Scarmato P, Harrison SC, Monroe JJ, Chow EP, Mattaliano RJ, Ramachandran KL, Smart JE, Ahn AH, Brosius J
published in: Science (New York, N.Y.)
information resource reference: Clathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs. Science. 1987 Apr 17; 236(4799):320-4.
journal title abbreviation: Science
publication date: 1987-04-17T00:00:00
year: 1987
type: Academic Article
type: Article
type: Document
type: Information Resource

Clathrin, cages, and coated vesicles.
PubMed Identifier: 6135512
author list: Harrison SC, Kirchhausen T
published in: Cell
information resource reference: Clathrin, cages, and coated vesicles. Cell. 1983 Jul; 33(3):650-2.
journal title abbreviation: Cell
publication date: 1983-07-01T00:00:00
year: 1983
type: Academic Article
type: Article
type: Document
type: Information Resource

Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds.
PubMed Identifier: 23629967
author list: Martinelli R, Kamei M, Sage PT, Massol R, Varghese L, Sciuto T, Toporsian M, Dvorak AM, Kirchhausen T, Springer TA, Carman CV
published in: The Journal of cell biology
information resource reference: Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds. J Cell Biol. 2013 Apr 29; 201(3):449-65.
journal title abbreviation: J Cell Biol
publication date: 2013-04-29T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly.
PubMed Identifier: 10219243
author list: Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T, Kirschner MW
published in: Cell
information resource reference: The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell. 1999 Apr 16; 97(2):221-31.
journal title abbreviation: Cell
publication date: 1999-04-16T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments.
PubMed Identifier: 22318319
author list: Strang BL, Boulant S, Kirchhausen T, Coen DM
published in: mBio
information resource reference: Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments. mBio. 2012; 3(1).
journal title abbreviation: mBio
publication date: 2012-02-07T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Studies on the inhibition of endosome fusion by GTPgammaS-bound ARF.
PubMed Identifier: 10504296
author list: Jones AT, Spiro DJ, Kirchhausen T, Melançon P, Wessling-Resnick M
published in: Journal of cell science
information resource reference: Studies on the inhibition of endosome fusion by GTPgammaS-bound ARF. J Cell Sci. 1999 Oct; 112 ( Pt 20):3477-85.
journal title abbreviation: J Cell Sci
publication date: 1999-10-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1010180
type: Authorship
author rank in publication: 5
linked author: Kirchhausen, Tomas
linked information resource: Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes.

Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes.
PubMed Identifier: 28910642
author list: Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J
published in: Cell
information resource reference: Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes. Cell. 2015 May 21; 161(5):1229.
journal title abbreviation: Cell
publication date: 2015-05-21T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Structure determination of clathrin coats to subnanometer resolution by single particle cryo-electron microscopy.
PubMed Identifier: 16908193
author list: Fotin A, Kirchhausen T, Grigorieff N, Harrison SC, Walz T, Cheng Y
published in: Journal of structural biology
information resource reference: Structure determination of clathrin coats to subnanometer resolution by single particle cryo-electron microscopy. J Struct Biol. 2006 Dec; 156(3):453-60.
journal title abbreviation: J Struct Biol
publication date: 2006-07-11T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading.
PubMed Identifier: 17312971
author list: Xu B, Pelish H, Kirchhausen T, Hammond GB
published in: Organic & biomolecular chemistry
information resource reference: Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading. Org Biomol Chem. 2006 Nov 21; 4(22):4149-57.
journal title abbreviation: Org Biomol Chem
publication date: 2006-11-21T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Endosomal recycling controls plasma membrane area during mitosis.
PubMed Identifier: 17483462
author list: Boucrot E, Kirchhausen T
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Endosomal recycling controls plasma membrane area during mitosis. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):7939-44.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2007-05-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210.
PubMed Identifier: 20089971
author list: Smits P, Bolton AD, Funari V, Hong M, Boyden ED, Lu L, Manning DK, Dwyer ND, Moran JL, Prysak M, Merriman B, Nelson SF, Bonafé L, Superti-Furga A, Ikegawa S, Krakow D, Cohn DH, Kirchhausen T, Warman ML, Beier DR
published in: The New England journal of medicine
information resource reference: Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210. N Engl J Med. 2010 Jan 21; 362(3):206-16.
journal title abbreviation: N Engl J Med
publication date: 2010-01-21T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Interaction of the bovine papillomavirus E6 protein with the clathrin adaptor complex AP-1.
PubMed Identifier: 9420248
author list: Tong X, Boll W, Kirchhausen T, Howley PM
published in: Journal of virology
information resource reference: Interaction of the bovine papillomavirus E6 protein with the clathrin adaptor complex AP-1. J Virol. 1998 Jan; 72(1):476-82.
journal title abbreviation: J Virol
publication date: 1998-01-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Similar uptake but different trafficking and escape routes of reovirus virions and infectious subvirion particles imaged in polarized Madin-Darby canine kidney cells.
PubMed Identifier: 23427267
author list: Boulant S, Stanifer M, Kural C, Cureton DK, Massol R, Nibert ML, Kirchhausen T
published in: Molecular biology of the cell
information resource reference: Similar uptake but different trafficking and escape routes of reovirus virions and infectious subvirion particles imaged in polarized Madin-Darby canine kidney cells. Mol Biol Cell. 2013 Apr; 24(8):1196-207.
journal title abbreviation: Mol Biol Cell
publication date: 2013-02-20T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Location and distribution of the light chains in clathrin trimers.
PubMed Identifier: 6189124
author list: Kirchhausen T, Harrison SC, Parham P, Brodsky FM
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Location and distribution of the light chains in clathrin trimers. Proc Natl Acad Sci U S A. 1983 May; 80(9):2481-5.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1983-05-01T00:00:00
year: 1983
type: Academic Article
type: Article
type: Document
type: Information Resource

A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles.
PubMed Identifier: 7923363
author list: Søgaard M, Tani K, Ye RR, Geromanos S, Tempst P, Kirchhausen T, Rothman JE, Söllner T
published in: Cell
information resource reference: A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Cell. 1994 Sep 23; 78(6):937-48.
journal title abbreviation: Cell
publication date: 1994-09-23T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Synthesis of a 10,000-membered library of molecules resembling carpanone and discovery of vesicular traffic inhibitors.
PubMed Identifier: 16620111
author list: Goess BC, Hannoush RN, Chan LK, Kirchhausen T, Shair MD
published in: Journal of the American Chemical Society
information resource reference: Synthesis of a 10,000-membered library of molecules resembling carpanone and discovery of vesicular traffic inhibitors. J Am Chem Soc. 2006 Apr 26; 128(16):5391-403.
journal title abbreviation: J Am Chem Soc
publication date: 2006-04-26T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Role of lipids and actin in the formation of clathrin-coated pits.
PubMed Identifier: 17097636
author list: Boucrot E, Saffarian S, Massol R, Kirchhausen T, Ehrlich M
published in: Experimental cell research
information resource reference: Role of lipids and actin in the formation of clathrin-coated pits. Exp Cell Res. 2006 Dec 10; 312(20):4036-48.
journal title abbreviation: Exp Cell Res
publication date: 2006-09-30T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

HIV Nef-mediated major histocompatibility complex class I down-modulation is independent of Arf6 activity.
PubMed Identifier: 14617802
author list: Larsen JE, Massol RH, Nieland TJ, Kirchhausen T
published in: Molecular biology of the cell
information resource reference: HIV Nef-mediated major histocompatibility complex class I down-modulation is independent of Arf6 activity. Mol Biol Cell. 2004 Jan; 15(1):323-31.
journal title abbreviation: Mol Biol Cell
publication date: 2003-11-14T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1019107
type: Authorship
author rank in publication: 15
linked author: Kirchhausen, Tomas
linked information resource: Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding.

Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding.
PubMed Identifier: 29019322
author list: Adell MAY, Migliano SM, Upadhyayula S, Bykov YS, Sprenger S, Pakdel M, Vogel GF, Jih G, Skillern W, Behrouzi R, Babst M, Schmidt O, Hess MW, Briggs JA, Kirchhausen T, Teis D
published in: eLife
information resource reference: Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding. Elife. 2017 10 11; 6.
journal title abbreviation: Elife
publication date: 2017-10-11T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.
PubMed Identifier: 16408091
author list: Pelish HE, Peterson JR, Salvarezza SB, Rodriguez-Boulan E, Chen JL, Stamnes M, Macia E, Feng Y, Shair MD, Kirchhausen T
published in: Nature chemical biology
information resource reference: Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro. Nat Chem Biol. 2006 Jan; 2(1):39-46.
journal title abbreviation: Nat Chem Biol
publication date: 2005-11-20T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Stabilization of clathrin coats by the core of the clathrin-associated protein complex AP-2.
PubMed Identifier: 2125494
author list: Matsui W, Kirchhausen T
published in: Biochemistry
information resource reference: Stabilization of clathrin coats by the core of the clathrin-associated protein complex AP-2. Biochemistry. 1990 Dec 04; 29(48):10791-8.
journal title abbreviation: Biochemistry
publication date: 1990-12-04T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

Macropinocytosis: regulated coordination of endocytic and exocytic membrane traffic events.
PubMed Identifier: 17077125
author list: Falcone S, Cocucci E, Podini P, Kirchhausen T, Clementi E, Meldolesi J
published in: Journal of cell science
information resource reference: Macropinocytosis: regulated coordination of endocytic and exocytic membrane traffic events. J Cell Sci. 2006 Nov 15; 119(Pt 22):4758-69.
journal title abbreviation: J Cell Sci
publication date: 2006-10-31T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling.
PubMed Identifier: 17199046
author list: Yu A, Rual JF, Tamai K, Harada Y, Vidal M, He X, Kirchhausen T
published in: Developmental cell
information resource reference: Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling. Dev Cell. 2007 Jan; 12(1):129-41.
journal title abbreviation: Dev Cell
publication date: 2007-01-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin.
PubMed Identifier: 19268609
author list: Shulman Z, Shinder V, Klein E, Grabovsky V, Yeger O, Geron E, Montresor A, Bolomini-Vittori M, Feigelson SW, Kirchhausen T, Laudanna C, Shakhar G, Alon R
published in: Immunity
information resource reference: Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin. Immunity. 2009 Mar 20; 30(3):384-96.
journal title abbreviation: Immunity
publication date: 2009-03-05T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Cisternal organization of the endoplasmic reticulum during mitosis.
PubMed Identifier: 19494040
author list: Lu L, Ladinsky MS, Kirchhausen T
published in: Molecular biology of the cell
information resource reference: Cisternal organization of the endoplasmic reticulum during mitosis. Mol Biol Cell. 2009 Aug; 20(15):3471-80.
journal title abbreviation: Mol Biol Cell
publication date: 2009-06-03T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Imaging endocytic clathrin structures in living cells.
PubMed Identifier: 19836955
author list: Kirchhausen T
published in: Trends in cell biology
information resource reference: Imaging endocytic clathrin structures in living cells. Trends Cell Biol. 2009 Nov; 19(11):596-605.
journal title abbreviation: Trends Cell Biol
publication date: 2009-11-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1024978
type: Authorship
author rank in publication: 8
linked author: Kirchhausen, Tomas
linked information resource: NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.

NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry.
PubMed Identifier: 29120745
author list: Raaben M, Jae LT, Herbert AS, Kuehne AI, Stubbs SH, Chou YY, Blomen VA, Kirchhausen T, Dye JM, Brummelkamp TR, Whelan SP
published in: Cell host & microbe
information resource reference: NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry. Cell Host Microbe. 2017 Nov 08; 22(5):688-696.e5.
journal title abbreviation: Cell Host Microbe
publication date: 2017-11-08T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Small-angle x-ray scattering study of human serum low-density lipoproteins with differential reactivity for an arterial proteoglycan.
PubMed Identifier: 211349
author list: Mateu L, Kirchhausen T, Padrón R, Camejo G
published in: Journal of supramolecular structure
information resource reference: Small-angle x-ray scattering study of human serum low-density lipoproteins with differential reactivity for an arterial proteoglycan. J Supramol Struct. 1977; 7(3-4):435-42.
journal title abbreviation: J Supramol Struct
publication date: 1977-01-01T00:00:00
year: 1977
type: Academic Article
type: Article
type: Document
type: Information Resource

Endocytosis is not required for the selective lipid uptake mediated by murine SR-BI.
PubMed Identifier: 15866482
author list: Nieland TJ, Ehrlich M, Krieger M, Kirchhausen T
published in: Biochimica et biophysica acta
information resource reference: Endocytosis is not required for the selective lipid uptake mediated by murine SR-BI. Biochim Biophys Acta. 2005 May 01; 1734(1):44-51.
journal title abbreviation: Biochim Biophys Acta
publication date: 2005-03-09T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Clathrin.
PubMed Identifier: 10966473
author list: Kirchhausen T
published in: Annual review of biochemistry
information resource reference: Clathrin. Annu Rev Biochem. 2000; 69:699-727.
journal title abbreviation: Annu Rev Biochem
publication date: 2000-01-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Tracking molecular particles in live cells using fuzzy rule-based system.
PubMed Identifier: 17542029
author list: Jiang S, Zhou X, Kirchhausen T, Wong ST
published in: Cytometry. Part A : the journal of the International Society for Analytical Cytology
information resource reference: Tracking molecular particles in live cells using fuzzy rule-based system. Cytometry A. 2007 Aug; 71(8):576-84.
journal title abbreviation: Cytometry A
publication date: 2007-08-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

The structure of plasma low density lipoproteins: experimental facts and interpretations--a minireview.
PubMed Identifier: 6772911
author list: Kirchhausen T, Fless G, Scanu AM
published in: Lipids
information resource reference: The structure of plasma low density lipoproteins: experimental facts and interpretations--a minireview. Lipids. 1980 Jun; 15(6):464-7.
journal title abbreviation: Lipids
publication date: 1980-06-01T00:00:00
year: 1980
type: Academic Article
type: Article
type: Document
type: Information Resource

Interaction of tyrosine-based sorting signals with clathrin-associated proteins.
PubMed Identifier: 7569928
author list: Ohno H, Stewart J, Fournier MC, Bosshart H, Rhee I, Miyatake S, Saito T, Gallusser A, Kirchhausen T, Bonifacino JS
published in: Science (New York, N.Y.)
information resource reference: Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science. 1995 Sep 29; 269(5232):1872-5.
journal title abbreviation: Science
publication date: 1995-09-29T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

T-cell engagement of dendritic cells rapidly rearranges MHC class II transport.
PubMed Identifier: 12198548
author list: Boes M, Cerny J, Massol R, Op den Brouw M, Kirchhausen T, Chen J, Ploegh HL
published in: Nature
information resource reference: T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature. 2002 Aug 29; 418(6901):983-8.
journal title abbreviation: Nature
publication date: 2002-08-29T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Redistribution of caveolae during mitosis.
PubMed Identifier: 21625007
author list: Boucrot E, Howes MT, Kirchhausen T, Parton RG
published in: Journal of cell science
information resource reference: Redistribution of caveolae during mitosis. J Cell Sci. 2011 Jun 15; 124(Pt 12):1965-72.
journal title abbreviation: J Cell Sci
publication date: 2011-06-15T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal.
PubMed Identifier: 17494868
author list: Wang J, Sun HQ, Macia E, Kirchhausen T, Watson H, Bonifacino JS, Yin HL
published in: Molecular biology of the cell
information resource reference: PI4P promotes the recruitment of the GGA adaptor proteins to the trans-Golgi network and regulates their recognition of the ubiquitin sorting signal. Mol Biol Cell. 2007 Jul; 18(7):2646-55.
journal title abbreviation: Mol Biol Cell
publication date: 2007-05-09T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Limited transferrin receptor clustering allows rapid diffusion of canine parvovirus into clathrin endocytic structures.
PubMed Identifier: 22357278
author list: Cureton DK, Harbison CE, Cocucci E, Parrish CR, Kirchhausen T
published in: Journal of virology
information resource reference: Limited transferrin receptor clustering allows rapid diffusion of canine parvovirus into clathrin endocytic structures. J Virol. 2012 May; 86(9):5330-40.
journal title abbreviation: J Virol
publication date: 2012-02-22T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Protein organization in clathrin trimers.
PubMed Identifier: 7226229
author list: Kirchhausen T, Harrison SC
published in: Cell
information resource reference: Protein organization in clathrin trimers. Cell. 1981 Mar; 23(3):755-61.
journal title abbreviation: Cell
publication date: 1981-03-01T00:00:00
year: 1981
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular characterization of an apical early endosomal glycoprotein from developing rat intestinal epithelial cells.
PubMed Identifier: 7829488
author list: Speelman BA, Allen K, Grounds TL, Neutra MR, Kirchhausen T, Wilson JM
published in: The Journal of biological chemistry
information resource reference: Molecular characterization of an apical early endosomal glycoprotein from developing rat intestinal epithelial cells. J Biol Chem. 1995 Jan 27; 270(4):1583-8.
journal title abbreviation: J Biol Chem
publication date: 1995-01-27T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Dynamics of intracellular clathrin/AP1- and clathrin/AP3-containing carriers.
PubMed Identifier: 23103167
author list: Kural C, Tacheva-Grigorova SK, Boulant S, Cocucci E, Baust T, Duarte D, Kirchhausen T
published in: Cell reports
information resource reference: Dynamics of intracellular clathrin/AP1- and clathrin/AP3-containing carriers. Cell Rep. 2012 Nov 29; 2(5):1111-9.
journal title abbreviation: Cell Rep
publication date: 2012-10-25T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Mammalian cells change volume during mitosis.
PubMed Identifier: 18213385
author list: Boucrot E, Kirchhausen T
published in: PloS one
information resource reference: Mammalian cells change volume during mitosis. PLoS One. 2008 Jan 23; 3(1):e1477.
journal title abbreviation: PLoS One
publication date: 2008-01-23T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1032083
type: Authorship
author rank in publication: 11
linked author: Kirchhausen, Tomas
linked information resource: Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic.

Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic.
PubMed Identifier: 29236694
author list: He K, Marsland R, Upadhyayula S, Song E, Dang S, Capraro BR, Wang W, Skillern W, Gaudin R, Ma M, Kirchhausen T
published in: Nature
information resource reference: Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic. Nature. 2017 12 21; 552(7685):410-414.
journal title abbreviation: Nature
publication date: 2017-12-13T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Distinct dynamics of endocytic clathrin-coated pits and coated plaques.
PubMed Identifier: 19809571
author list: Saffarian S, Cocucci E, Kirchhausen T
published in: PLoS biology
information resource reference: Distinct dynamics of endocytic clathrin-coated pits and coated plaques. PLoS Biol. 2009 Sep; 7(9):e1000191.
journal title abbreviation: PLoS Biol
publication date: 2009-09-08T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Structure of the PTEN-like region of auxilin, a detector of clathrin-coated vesicle budding.
PubMed Identifier: 20826345
author list: Guan R, Dai H, Han D, Harrison SC, Kirchhausen T
published in: Structure (London, England : 1993)
information resource reference: Structure of the PTEN-like region of auxilin, a detector of clathrin-coated vesicle budding. Structure. 2010 Sep 08; 18(9):1191-8.
journal title abbreviation: Structure
publication date: 2010-09-08T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating.
PubMed Identifier: 21278753
author list: Böcking T, Aguet F, Harrison SC, Kirchhausen T
published in: Nature structural & molecular biology
information resource reference: Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating. Nat Struct Mol Biol. 2011 Mar; 18(3):295-301.
journal title abbreviation: Nat Struct Mol Biol
publication date: 2011-01-30T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Live-cell imaging of clathrin coats.
PubMed Identifier: 22289448
author list: Kural C, Kirchhausen T
published in: Methods in enzymology
information resource reference: Live-cell imaging of clathrin coats. Methods Enzymol. 2012; 505:59-80.
journal title abbreviation: Methods Enzymol
publication date: 2012-01-01T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Structural domains of clathrin heavy chains.
PubMed Identifier: 6386825
author list: Kirchhausen T, Harrison SC
published in: The Journal of cell biology
information resource reference: Structural domains of clathrin heavy chains. J Cell Biol. 1984 Nov; 99(5):1725-34.
journal title abbreviation: J Cell Biol
publication date: 1984-11-01T00:00:00
year: 1984
type: Academic Article
type: Article
type: Document
type: Information Resource

The Saccharomyces cerevisiae APS1 gene encodes a homolog of the small subunit of the mammalian clathrin AP-1 complex: evidence for functional interaction with clathrin at the Golgi complex.
PubMed Identifier: 8157009
author list: Phan HL, Finlay JA, Chu DS, Tan PK, Kirchhausen T, Payne GS
published in: The EMBO journal
information resource reference: The Saccharomyces cerevisiae APS1 gene encodes a homolog of the small subunit of the mammalian clathrin AP-1 complex: evidence for functional interaction with clathrin at the Golgi complex. EMBO J. 1994 Apr 01; 13(7):1706-17.
journal title abbreviation: EMBO J
publication date: 1994-04-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components.
PubMed Identifier: 8262066
author list: Gallusser A, Kirchhausen T
published in: The EMBO journal
information resource reference: The beta 1 and beta 2 subunits of the AP complexes are the clathrin coat assembly components. EMBO J. 1993 Dec 15; 12(13):5237-44.
journal title abbreviation: EMBO J
publication date: 1993-12-15T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Invasive and adherent bacterial pathogens co-Opt host clathrin for infection.
PubMed Identifier: 18005755
author list: Veiga E, Guttman JA, Bonazzi M, Boucrot E, Toledo-Arana A, Lin AE, Enninga J, Pizarro-Cerdá J, Finlay BB, Kirchhausen T, Cossart P
published in: Cell host & microbe
information resource reference: Invasive and adherent bacterial pathogens co-Opt host clathrin for infection. Cell Host Microbe. 2007 Nov 15; 2(5):340-51.
journal title abbreviation: Cell Host Microbe
publication date: 2007-11-15T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

DNA gyrase and its complexes with DNA: direct observation by electron microscopy.
PubMed Identifier: 2988794
author list: Kirchhausen T, Wang JC, Harrison SC
published in: Cell
information resource reference: DNA gyrase and its complexes with DNA: direct observation by electron microscopy. Cell. 1985 Jul; 41(3):933-43.
journal title abbreviation: Cell
publication date: 1985-07-01T00:00:00
year: 1985
type: Academic Article
type: Article
type: Document
type: Information Resource

Membranes and sorting. Membrane permeability.
PubMed Identifier: 9261064
author list: Kirchhausen T, Pines J, Toldo L, Lafont F
published in: Current opinion in cell biology
information resource reference: Membranes and sorting. Membrane permeability. Curr Opin Cell Biol. 1997 Jul 01; 9(4):473.
journal title abbreviation: Curr Opin Cell Biol
publication date: 1997-07-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Assembly of clathrin coats disrupts the association between Eps15 and AP-2 adaptors.
PubMed Identifier: 9442014
author list: Cupers P, Jadhav AP, Kirchhausen T
published in: The Journal of biological chemistry
information resource reference: Assembly of clathrin coats disrupts the association between Eps15 and AP-2 adaptors. J Biol Chem. 1998 Jan 23; 273(4):1847-50.
journal title abbreviation: J Biol Chem
publication date: 1998-01-23T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

The neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway.
PubMed Identifier: 9651214
author list: Kamiguchi H, Long KE, Pendergast M, Schaefer AW, Rapoport I, Kirchhausen T, Lemmon V
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: The neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway. J Neurosci. 1998 Jul 15; 18(14):5311-21.
journal title abbreviation: J Neurosci
publication date: 1998-07-15T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

The clathrin endocytic pathway in viral infection.
PubMed Identifier: 9707418
author list: DeTulleo L, Kirchhausen T
published in: The EMBO journal
information resource reference: The clathrin endocytic pathway in viral infection. EMBO J. 1998 Aug 17; 17(16):4585-93.
journal title abbreviation: EMBO J
publication date: 1998-08-17T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Phenotypic screening of small molecule libraries by high throughput cell imaging.
PubMed Identifier: 12769670
author list: Yarrow JC, Feng Y, Perlman ZE, Kirchhausen T, Mitchison TJ
published in: Combinatorial chemistry & high throughput screening
information resource reference: Phenotypic screening of small molecule libraries by high throughput cell imaging. Comb Chem High Throughput Screen. 2003 Jun; 6(4):279-86.
journal title abbreviation: Comb Chem High Throughput Screen
publication date: 2003-06-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

A role for the hinge/ear domain of the beta chains in the incorporation of AP complexes into clathrin-coated pits and coated vesicles.
PubMed Identifier: 9284964
author list: Clairmont KB, Boll W, Ericsson M, Kirchhausen T
published in: Cellular and molecular life sciences : CMLS
information resource reference: A role for the hinge/ear domain of the beta chains in the incorporation of AP complexes into clathrin-coated pits and coated vesicles. Cell Mol Life Sci. 1997 Jul; 53(7):611-9.
journal title abbreviation: Cell Mol Life Sci
publication date: 1997-07-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Parallel dimers and anti-parallel tetramers formed by epidermal growth factor receptor pathway substrate clone 15.
PubMed Identifier: 9407139
author list: Cupers P, ter Haar E, Boll W, Kirchhausen T
published in: The Journal of biological chemistry
information resource reference: Parallel dimers and anti-parallel tetramers formed by epidermal growth factor receptor pathway substrate clone 15. J Biol Chem. 1997 Dec 26; 272(52):33430-4.
journal title abbreviation: J Biol Chem
publication date: 1997-12-26T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Wiskott-Aldrich syndrome: a gene, a multifunctional protein and the beginnings of an explanation.
PubMed Identifier: 9743991
author list: Kirchhausen T
published in: Molecular medicine today
information resource reference: Wiskott-Aldrich syndrome: a gene, a multifunctional protein and the beginnings of an explanation. Mol Med Today. 1998 Jul; 4(7):300-4.
journal title abbreviation: Mol Med Today
publication date: 1998-07-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes.
PubMed Identifier: 15802264
author list: Paleotti O, Macia E, Luton F, Klein S, Partisani M, Chardin P, Kirchhausen T, Franco M
published in: The Journal of biological chemistry
information resource reference: The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes. J Biol Chem. 2005 Jun 03; 280(22):21661-6.
journal title abbreviation: J Biol Chem
publication date: 2005-03-31T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Possible role of deep tubular invaginations of the plasma membrane in MHC-I trafficking.
PubMed Identifier: 15878340
author list: Massol RH, Larsen JE, Kirchhausen T
published in: Experimental cell research
information resource reference: Possible role of deep tubular invaginations of the plasma membrane in MHC-I trafficking. Exp Cell Res. 2005 May 15; 306(1):142-9.
journal title abbreviation: Exp Cell Res
publication date: 2005-03-23T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

The Cdc42 inhibitor secramine B prevents cAMP-induced K+ conductance in intestinal epithelial cells.
PubMed Identifier: 16677615
author list: Pelish HE, Ciesla W, Tanaka N, Reddy K, Shair MD, Kirchhausen T, Lencer WI
published in: Biochemical pharmacology
information resource reference: The Cdc42 inhibitor secramine B prevents cAMP-induced K+ conductance in intestinal epithelial cells. Biochem Pharmacol. 2006 Jun 14; 71(12):1720-6.
journal title abbreviation: Biochem Pharmacol
publication date: 2006-03-18T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Adaptors for clathrin-mediated traffic.
PubMed Identifier: 10611976
author list: Kirchhausen T
published in: Annual review of cell and developmental biology
information resource reference: Adaptors for clathrin-mediated traffic. Annu Rev Cell Dev Biol. 1999; 15:705-32.
journal title abbreviation: Annu Rev Cell Dev Biol
publication date: 1999-01-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Structure of the Sec23p/24p and Sec13p/31p complexes of COPII.
PubMed Identifier: 11535824
author list: Lederkremer GZ, Cheng Y, Petre BM, Vogan E, Springer S, Schekman R, Walz T, Kirchhausen T
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Structure of the Sec23p/24p and Sec13p/31p complexes of COPII. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10704-9.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2001-09-04T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Constriction and Dnm1p recruitment are distinct processes in mitochondrial fission.
PubMed Identifier: 12802067
author list: Legesse-Miller A, Massol RH, Kirchhausen T
published in: Molecular biology of the cell
information resource reference: Constriction and Dnm1p recruitment are distinct processes in mitochondrial fission. Mol Biol Cell. 2003 May; 14(5):1953-63.
journal title abbreviation: Mol Biol Cell
publication date: 2003-02-06T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource