SJE2StephenElledgeStephen J. Elledge, Ph.D.42.33837200000000-71.1032690000000032424Elledge, StephenJ.617/525-4510Gregor Mendel Professor of Genetics and of Medicinecatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson10935617Cortez D, Elledge SJNatureConducting the mitotic symphony. Nature. 2000 Jul 27; 406(6794):354-6.Nature2000-07-27T00:00:002000Conducting the mitotic symphony.11799062Li Y, Bachant J, Alcasabas AA, Wang Y, Qin J, Elledge SJGenes & developmentThe mitotic spindle is required for loading of the DASH complex onto the kinetochore. Genes Dev. 2002 Jan 15; 16(2):183-97.Genes Dev2002-01-15T00:00:002002The mitotic spindle is required for loading of the DASH complex onto the kinetochore.Authorship 10475261029373832Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, Hochedlinger KCellNudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling. Cell. 2018 01 25; 172(3):629-631.Cell2018-01-25T00:00:002018Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.10097122Wang H, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaDRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3824-9.Proc Natl Acad Sci U S A1999-03-30T00:00:001999DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae.11790307Weiss RS, Matsuoka S, Elledge SJ, Leder PCurrent biology : CBHus1 acts upstream of chk1 in a mammalian DNA damage response pathway. Curr Biol. 2002 Jan 08; 12(1):73-7.Curr Biol2002-01-08T00:00:002002Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway.2448583Snyder M, Elledge S, Sweetser D, Young RA, Davis RWMethods in enzymologyLambda gt 11: gene isolation with antibody probes and other applications. Methods Enzymol. 1987; 154:107-28.Methods Enzymol1987-01-01T00:00:001987Lambda gt 11: gene isolation with antibody probes and other applications.16196126Perry KL, Elledge SJ, Mitchell BB, Marsh L, Walker GCDNA repairumuDC and mucAB operons whose products are required for UV light- and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share homology. 1985. DNA Repair (Amst). 2005 Aug 15; 4(9):1054-8.DNA Repair (Amst)2005-08-15T00:00:002005umuDC and mucAB operons whose products are required for UV light- and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share homology. 1985.16217032Lin SY, Rai R, Li K, Xu ZX, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaBRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15105-9.Proc Natl Acad Sci U S A2005-10-10T00:00:002005BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly.3313004Elledge SJ, Davis RWMolecular and cellular biologyIdentification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability. Mol Cell Biol. 1987 Aug; 7(8):2783-93.Mol Cell Biol1987-08-01T00:00:001987Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability.Authorship 10545761629576454Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, Elledge SJCellProfound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns. Cell. 2018 04 05; 173(2):499-514.e23.Cell2018-03-22T00:00:002018Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns.8332187Zhang XF, Settleman J, Kyriakis JM, Takeuchi-Suzuki E, Elledge SJ, Marshall MS, Bruder JT, Rapp UR, Avruch JNatureNormal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature. 1993 Jul 22; 364(6435):308-13.Nature1993-07-22T00:00:001993Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1.9315670Huang M, Elledge SJMolecular and cellular biologyIdentification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae. Mol Cell Biol. 1997 Oct; 17(10):6105-13.Mol Cell Biol1997-10-01T00:00:001997Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae.10213691Kamura T, Koepp DM, Conrad MN, Skowyra D, Moreland RJ, Iliopoulos O, Lane WS, Kaelin WG, Elledge SJ, Conaway RC, Harper JW, Conaway JWScience (New York, N.Y.)Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Science. 1999 Apr 23; 284(5414):657-61.Science1999-04-23T00:00:001999Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.11137997Cho RJ, Huang M, Campbell MJ, Dong H, Steinmetz L, Sapinoso L, Hampton G, Elledge SJ, Davis RW, Lockhart DJNature geneticsTranscriptional regulation and function during the human cell cycle. Nat Genet. 2001 Jan; 27(1):48-54.Nat Genet2001-01-01T00:00:002001Transcriptional regulation and function during the human cell cycle.Authorship 10545637815490Lee TH, Elledge SJ, Butel JSJournal of virologyHepatitis B virus X protein interacts with a probable cellular DNA repair protein. J Virol. 1995 Feb; 69(2):1107-14.J Virol1995-02-01T00:00:001995Hepatitis B virus X protein interacts with a probable cellular DNA repair protein.8197174Li L, Elledge SJ, Peterson CA, Bales ES, Legerski RJProceedings of the National Academy of Sciences of the United States of AmericaSpecific association between the human DNA repair proteins XPA and ERCC1. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):5012-6.Proc Natl Acad Sci U S A1994-05-24T00:00:001994Specific association between the human DNA repair proteins XPA and ERCC1.8618920Hoovers JM, Kalikin LM, Johnson LA, Alders M, Redeker B, Law DJ, Bliek J, Steenman M, Benedict M, Wiegant J, Lengauer C, Taillon-Miller P, Schlessinger D, Edwards MC, Elledge SJ, Ivens A, Westerveld A, Little P, Mannens M, Feinberg APProceedings of the National Academy of Sciences of the United States of AmericaMultiple genetic loci within 11p15 defined by Beckwith-Wiedemann syndrome rearrangement breakpoints and subchromosomal transferable fragments. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26):12456-60.Proc Natl Acad Sci U S A1995-12-19T00:00:001995Multiple genetic loci within 11p15 defined by Beckwith-Wiedemann syndrome rearrangement breakpoints and subchromosomal transferable fragments.17293868Li MZ, Elledge SJNature methodsHarnessing homologous recombination in vitro to generate recombinant DNA via SLIC. Nat Methods. 2007 Mar; 4(3):251-6.Nat Methods2007-02-11T00:00:002007Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC.23658454John SP, Chin CR, Perreira JM, Feeley EM, Aker AM, Savidis G, Smith SE, Elia AE, Everitt AR, Vora M, Pertel T, Elledge SJ, Kellam P, Brass ALJournal of virologyThe CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication. J Virol. 2013 Jul; 87(14):7837-52.J Virol2013-05-08T00:00:002013The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication.12086615Bachant J, Alcasabas A, Blat Y, Kleckner N, Elledge SJMolecular cellThe SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II. Mol Cell. 2002 Jun; 9(6):1169-82.Mol Cell2002-06-01T00:00:002002The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II.12837246Lin SY, Elledge SJCellMultiple tumor suppressor pathways negatively regulate telomerase. Cell. 2003 Jun 27; 113(7):881-9.Cell2003-06-27T00:00:002003Multiple tumor suppressor pathways negatively regulate telomerase.20810650Hurov KE, Cotta-Ramusino C, Elledge SJGenes & developmentA genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. Genes Dev. 2010 Sep 01; 24(17):1939-50.Genes Dev2010-09-01T00:00:002010A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.15042091Paddison PJ, Silva JM, Conklin DS, Schlabach M, Li M, Aruleba S, Balija V, O'Shaughnessy A, Gnoj L, Scobie K, Chang K, Westbrook T, Cleary M, Sachidanandam R, McCombie WR, Elledge SJ, Hannon GJNatureA resource for large-scale RNA-interference-based screens in mammals. Nature. 2004 Mar 25; 428(6981):427-31.Nature2004-03-25T00:00:002004A resource for large-scale RNA-interference-based screens in mammals.19061646Mulligan P, Westbrook TF, Ottinger M, Pavlova N, Chang B, Macia E, Shi YJ, Barretina J, Liu J, Howley PM, Elledge SJ, Shi YMolecular cellCDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. Mol Cell. 2008 Dec 05; 32(5):718-26.Mol Cell2008-12-05T00:00:002008CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.22704558Ciccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJ, Izhar L, Petit SA, Adamson B, Yoon JC, Kowalczykowski SC, Livingston DM, Haracska L, Elledge SJMolecular cellPolyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Mol Cell. 2012 Aug 10; 47(3):396-409.Mol Cell2012-06-14T00:00:002012Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.2989816Perry KL, Elledge SJ, Mitchell BB, Marsh L, Walker GCProceedings of the National Academy of Sciences of the United States of AmericaumuDC and mucAB operons whose products are required for UV light- and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share homology. Proc Natl Acad Sci U S A. 1985 Jul; 82(13):4331-5.Proc Natl Acad Sci U S A1985-07-01T00:00:001985umuDC and mucAB operons whose products are required for UV light- and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share homology.23064642Larman HB, Xu GJ, Pavlova NN, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaConstruction of a rationally designed antibody platform for sequencing-assisted selection. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18523-8.Proc Natl Acad Sci U S A2012-10-11T00:00:002012Construction of a rationally designed antibody platform for sequencing-assisted selection.7664341Sicinski P, Donaher JL, Parker SB, Li T, Fazeli A, Gardner H, Haslam SZ, Bronson RT, Elledge SJ, Weinberg RACellCyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell. 1995 Aug 25; 82(4):621-30.Cell1995-08-25T00:00:001995Cyclin D1 provides a link between development and oncogenesis in the retina and breast.8343143Elledge SJ, Zhou Z, Allen JB, Navas TABioEssays : news and reviews in molecular, cellular and developmental biologyDNA damage and cell cycle regulation of ribonucleotide reductase. Bioessays. 1993 May; 15(5):333-9.Bioessays1993-05-01T00:00:001993DNA damage and cell cycle regulation of ribonucleotide reductase.8610162Matsuoka S, Thompson JS, Edwards MC, Bartletta JM, Grundy P, Kalikin LM, Harper JW, Elledge SJ, Feinberg APProceedings of the National Academy of Sciences of the United States of AmericaImprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15. Proc Natl Acad Sci U S A. 1996 Apr 02; 93(7):3026-30.Proc Natl Acad Sci U S A1996-04-02T00:00:001996Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15.17495026Stegmeier F, Sowa ME, Nalepa G, Gygi SP, Harper JW, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaThe tumor suppressor CYLD regulates entry into mitosis. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):8869-74.Proc Natl Acad Sci U S A2007-05-10T00:00:002007The tumor suppressor CYLD regulates entry into mitosis.Authorship 1064372829775578Lin HC, Yeh CW, Chen YF, Lee TT, Hsieh PY, Rusnac DV, Lin SY, Elledge SJ, Zheng N, Yen HSMolecular cellC-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases. Mol Cell. 2018 05 17; 70(4):602-613.e3.Mol Cell2018-05-17T00:00:002018C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases.Authorship 1068063629779948Koren I, Timms RT, Kula T, Xu Q, Li MZ, Elledge SJCellThe Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons. Cell. 2018 06 14; 173(7):1622-1635.e14.Cell2018-05-17T00:00:002018The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons.20473325Fishler T, Li YY, Wang RH, Kim HS, Sengupta K, Vassilopoulos A, Lahusen T, Xu X, Lee MH, Liu Q, Elledge SJ, Ried T, Deng CXOncogeneGenetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53. Oncogene. 2010 Jul 15; 29(28):4007-17.Oncogene2010-05-17T00:00:002010Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53.21376233Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ, Westbrook TFCellActivation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell. 2011 Mar 04; 144(5):703-18.Cell2011-03-04T00:00:002011Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase.21659603Cotta-Ramusino C, McDonald ER, Hurov K, Sowa ME, Harper JW, Elledge SJScience (New York, N.Y.)A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. Science. 2011 Jun 10; 332(6035):1313-7.Science2011-06-10T00:00:002011A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.15731760Li MZ, Elledge SJNature geneticsMAGIC, an in vivo genetic method for the rapid construction of recombinant DNA molecules. Nat Genet. 2005 Mar; 37(3):311-9.Nat Genet2005-01-30T00:00:002005MAGIC, an in vivo genetic method for the rapid construction of recombinant DNA molecules.10454593Ouspenski II, Elledge SJ, Brinkley BRNucleic acids researchNew yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res. 1999 Aug 01; 27(15):3001-8.Nucleic Acids Res1999-08-01T00:00:001999New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability.17940005Stewart GS, Stankovic T, Byrd PJ, Wechsler T, Miller ES, Huissoon A, Drayson MT, West SC, Elledge SJ, Taylor AMProceedings of the National Academy of Sciences of the United States of AmericaRIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):16910-5.Proc Natl Acad Sci U S A2007-10-16T00:00:002007RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling.18239125Silva JM, Marran K, Parker JS, Silva J, Golding M, Schlabach MR, Elledge SJ, Hannon GJ, Chang KScience (New York, N.Y.)Profiling essential genes in human mammary cells by multiplex RNAi screening. Science. 2008 Feb 01; 319(5863):617-20.Science2008-02-01T00:00:002008Profiling essential genes in human mammary cells by multiplex RNAi screening.11973288Wang H, Elledge SJGeneticsGenetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics. 2002 Apr; 160(4):1295-304.Genetics2002-04-01T00:00:002002Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway.1692556Jasin M, Elledge SJ, Davis RW, Berg PGenes & developmentGene targeting at the human CD4 locus by epitope addition. Genes Dev. 1990 Feb; 4(2):157-66.Genes Dev1990-02-01T00:00:001990Gene targeting at the human CD4 locus by epitope addition.20603073Smogorzewska A, Desetty R, Saito TT, Schlabach M, Lach FP, Sowa ME, Clark AB, Kunkel TA, Harper JW, Colaiácovo MP, Elledge SJMolecular cellA genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Mol Cell. 2010 Jul 09; 39(1):36-47.Mol Cell2010-07-09T00:00:002010A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.22494569Elia AE, Elledge SJBreast cancer research : BCRBRCA1 as tumor suppressor: lord without its RING? Breast Cancer Res. 2012 Apr 10; 14(2):306.Breast Cancer Res2012-04-10T00:00:002012BRCA1 as tumor suppressor: lord without its RING?16239460Elledge SJ, Hannon GJScience (New York, N.Y.)An open letter to cancer researchers. Science. 2005 Oct 21; 310(5747):439-41.Science2005-10-21T00:00:002005An open letter to cancer researchers.18519633Burrows AE, Elledge SJGenes & developmentHow ATR turns on: TopBP1 goes on ATRIP with ATR. Genes Dev. 2008 Jun 01; 22(11):1416-21.Genes Dev2008-06-01T00:00:002008How ATR turns on: TopBP1 goes on ATRIP with ATR.19515819Naylor ML, Li JM, Osborn AJ, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaMrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12765-70.Proc Natl Acad Sci U S A2009-06-10T00:00:002009Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork.20634317Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJGenes & developmentWnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev. 2010 Jul 15; 24(14):1507-18.Genes Dev2010-07-15T00:00:002010Wnt signaling regulates mitochondrial physiology and insulin sensitivity.21353615Fellmann C, Zuber J, McJunkin K, Chang K, Malone CD, Dickins RA, Xu Q, Hengartner MO, Elledge SJ, Hannon GJ, Lowe SWMolecular cellFunctional identification of optimized RNAi triggers using a massively parallel sensor assay. Mol Cell. 2011 Mar 18; 41(6):733-46.Mol Cell2011-02-25T00:00:002011Functional identification of optimized RNAi triggers using a massively parallel sensor assay.18669648Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SPProceedings of the National Academy of Sciences of the United States of AmericaA quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 05; 105(31):10762-7.Proc Natl Acad Sci U S A2008-07-31T00:00:002008A quantitative atlas of mitotic phosphorylation.Authorship 1121411218354483Westbrook TF, Hu G, Ang XL, Mulligan P, Pavlova NN, Liang A, Leng Y, Maehr R, Shi Y, Harper JW, Elledge SJNatureSCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature. 2008 Mar 20; 452(7185):370-4.Nature2008-03-20T00:00:002008SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation.7626805Harper JW, Elledge SJ, Keyomarsi K, Dynlacht B, Tsai LH, Zhang P, Dobrowolski S, Bai C, Connell-Crowley L, Swindell EMolecular biology of the cellInhibition of cyclin-dependent kinases by p21. Mol Biol Cell. 1995 Apr; 6(4):387-400.Mol Biol Cell1995-04-01T00:00:001995Inhibition of cyclin-dependent kinases by p21.18988847Yen HC, Xu Q, Chou DM, Zhao Z, Elledge SJScience (New York, N.Y.)Global protein stability profiling in mammalian cells. Science. 2008 Nov 07; 322(5903):918-23.Science2008-11-07T00:00:002008Global protein stability profiling in mammalian cells.19171886Xu Q, Schlabach MR, Hannon GJ, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaDesign of 240,000 orthogonal 25mer DNA barcode probes. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2289-94.Proc Natl Acad Sci U S A2009-01-26T00:00:002009Design of 240,000 orthogonal 25mer DNA barcode probes.Authorship 108969727Authorship 1088879430143481Hernandez N, Melki I, Jing H, Habib T, Huang SSY, Danielson J, Kula T, Drutman S, Belkaya S, Rattina V, Lorenzo-Diaz L, Boulai A, Rose Y, Kitabayashi N, Rodero MP, Dumaine C, Blanche S, Lebras MN, Leung MC, Mathew LS, Boisson B, Zhang SY, Boisson-Dupuis S, Giliani S, Chaussabel D, Notarangelo LD, Elledge SJ, Ciancanelli MJ, Abel L, Zhang Q, Marr N, Crow YJ, Su HC, Casanova JLThe Journal of experimental medicineLife-threatening influenza pneumonitis in a child with inherited IRF9 deficiency. J Exp Med. 2018 10 01; 215(10):2567-2585.J Exp Med2018-08-24T00:00:002018Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency.30135075Liao S, Maertens O, Cichowski K, Elledge SJGenes & developmentGenetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is. Genes Dev. 2018 09 01; 32(17-18):1188-1200.Genes Dev2018-08-22T00:00:002018Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is.20064371Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJCellThe IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell. 2009 Dec 24; 139(7):1243-54.Cell2009-12-24T00:00:002009The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.2982787Winans SC, Elledge SJ, Krueger JH, Walker GCJournal of bacteriologySite-directed insertion and deletion mutagenesis with cloned fragments in Escherichia coli. J Bacteriol. 1985 Mar; 161(3):1219-21.J Bacteriol1985-03-01T00:00:001985Site-directed insertion and deletion mutagenesis with cloned fragments in Escherichia coli.23295261Wang CI, Alekseyenko AA, LeRoy G, Elia AE, Gorchakov AA, Britton LM, Elledge SJ, Kharchenko PV, Garcia BA, Kuroda MINature structural & molecular biologyChromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila. Nat Struct Mol Biol. 2013 Feb; 20(2):202-9.Nat Struct Mol Biol2013-01-06T00:00:002013Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila.8242751Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJCellThe p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 1993 Nov 19; 75(4):805-16.Cell1993-11-19T00:00:001993The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.21253575Huang IC, Bailey CC, Weyer JL, Radoshitzky SR, Becker MM, Chiang JJ, Brass AL, Ahmed AA, Chi X, Dong L, Longobardi LE, Boltz D, Kuhn JH, Elledge SJ, Bavari S, Denison MR, Choe H, Farzan MPLoS pathogensDistinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog. 2011 Jan 06; 7(1):e1001258.PLoS Pathog2011-01-06T00:00:002011Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.3003747Snyder M, Elledge S, Davis RWProceedings of the National Academy of Sciences of the United States of AmericaRapid mapping of antigenic coding regions and constructing insertion mutations in yeast genes by mini-Tn10 "transplason" mutagenesis. Proc Natl Acad Sci U S A. 1986 Feb; 83(3):730-4.Proc Natl Acad Sci U S A1986-02-01T00:00:001986Rapid mapping of antigenic coding regions and constructing insertion mutations in yeast genes by mini-Tn10 "transplason" mutagenesis.19269363Luo J, Solimini NL, Elledge SJCellPrinciples of cancer therapy: oncogene and non-oncogene addiction. Cell. 2009 Mar 06; 136(5):823-37.Cell2009-03-06T00:00:002009Principles of cancer therapy: oncogene and non-oncogene addiction.Authorship 1079312Authorship 10959221930249792Rousseaux MWC, Vázquez-Vélez GE, Al-Ramahi I, Jeong HH, Bajic A, Revelli JP, Ye H, Phan ET, Deger JM, Perez AM, Kim JY, Lavery LA, Xu Q, Li MZ, Kang H, Kim JJ, Shulman JM, Westbrook TF, Elledge SJ, Liu Z, Botas J, Zoghbi HYThe Journal of neuroscience : the official journal of the Society for NeuroscienceA Druggable Genome Screen Identifies Modifiers of a-Synuclein Levels via a Tiered Cross-Species Validation Approach. J Neurosci. 2018 10 24; 38(43):9286-9301.J Neurosci2018-09-24T00:00:002018A Druggable Genome Screen Identifies Modifiers of a-Synuclein Levels via a Tiered Cross-Species Validation Approach.15960972Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJCellA genetic screen for candidate tumor suppressors identifies REST. Cell. 2005 Jun 17; 121(6):837-48.Cell2005-06-17T00:00:002005A genetic screen for candidate tumor suppressors identifies REST.17360434Zaugg K, Su YW, Reilly PT, Moolani Y, Cheung CC, Hakem R, Hirao A, Liu Q, Elledge SJ, Mak TWProceedings of the National Academy of Sciences of the United States of AmericaCross-talk between Chk1 and Chk2 in double-mutant thymocytes. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):3805-10.Proc Natl Acad Sci U S A2007-02-26T00:00:002007Cross-talk between Chk1 and Chk2 in double-mutant thymocytes.9251023Dynlacht BD, Ngwu C, Winston J, Swindell EC, Elledge SJ, Harlow E, Harper JWMethods in enzymologyPurification and analysis of CIP/KIP proteins. Methods Enzymol. 1997; 283:230-44.Methods Enzymol1997-01-01T00:00:001997Purification and analysis of CIP/KIP proteins.9346238Skowyra D, Craig KL, Tyers M, Elledge SJ, Harper JWCellF-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell. 1997 Oct 17; 91(2):209-19.Cell1997-10-17T00:00:001997F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.9632813Edwards MC, Wong C, Elledge SJMolecular and cellular biologyHuman cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. Mol Cell Biol. 1998 Jul; 18(7):4291-300.Mol Cell Biol1998-07-01T00:00:001998Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity.7836422Ouspenski II, Mueller UW, Matynia A, Sazer S, Elledge SJ, Brinkley BRThe Journal of biological chemistryRan-binding protein-1 is an essential component of the Ran/RCC1 molecular switch system in budding yeast. J Biol Chem. 1995 Feb 03; 270(5):1975-8.J Biol Chem1995-02-03T00:00:001995Ran-binding protein-1 is an essential component of the Ran/RCC1 molecular switch system in budding yeast.8549741Helps NR, Barker HM, Elledge SJ, Cohen PTFEBS lettersProtein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53. FEBS Lett. 1995 Dec 27; 377(3):295-300.FEBS Lett1995-12-27T00:00:001995Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53.19490893Luo J, Emanuele MJ, Li D, Creighton CJ, Schlabach MR, Westbrook TF, Wong KK, Elledge SJCellA genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell. 2009 May 29; 137(5):835-48.Cell2009-05-29T00:00:002009A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.Authorship 128756621788515Hajdu I, Ciccia A, Lewis SM, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaWolf-Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage. Proc Natl Acad Sci U S A. 2011 Aug 09; 108(32):13130-4.Proc Natl Acad Sci U S A2011-07-25T00:00:002011Wolf-Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage.22046135Feeley EM, Sims JS, John SP, Chin CR, Pertel T, Chen LM, Gaiha GD, Ryan BJ, Donis RO, Elledge SJ, Brass ALPLoS pathogensIFITM3 inhibits influenza A virus infection by preventing cytosolic entry. PLoS Pathog. 2011 Oct; 7(10):e1002337.PLoS Pathog2011-10-27T00:00:002011IFITM3 inhibits influenza A virus infection by preventing cytosolic entry.8553072Sanchez Y, Desany BA, Jones WJ, Liu Q, Wang B, Elledge SJScience (New York, N.Y.)Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science. 1996 Jan 19; 271(5247):357-60.Science1996-01-19T00:00:001996Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways.9741624Huang M, Zhou Z, Elledge SJCellThe DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Cell. 1998 Sep 04; 94(5):595-605.Cell1998-09-04T00:00:001998The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor.9858559Gómez Lahoz E, Liegeois NJ, Zhang P, Engelman JA, Horner J, Silverman A, Burde R, Roussel MF, Sherr CJ, Elledge SJ, DePinho RAMolecular and cellular biologyCyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo. Mol Cell Biol. 1999 Jan; 19(1):353-63.Mol Cell Biol1999-01-01T00:00:001999Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo.10235256Bachant JB, Elledge SJNatureMitotic treasures in the nucleolus. Nature. 1999 Apr 29; 398(6730):757-8.Nature1999-04-29T00:00:001999Mitotic treasures in the nucleolus.6302271Elledge SJ, Walker GCJournal of molecular biologyProteins required for ultraviolet light and chemical mutagenesis. Identification of the products of the umuC locus of Escherichia coli. J Mol Biol. 1983 Feb 25; 164(2):175-92.J Mol Biol1983-02-25T00:00:001983Proteins required for ultraviolet light and chemical mutagenesis. Identification of the products of the umuC locus of Escherichia coli.6350267Elledge SJ, Walker GCJournal of bacteriologyThe muc genes of pKM101 are induced by DNA damage. J Bacteriol. 1983 Sep; 155(3):1306-15.J Bacteriol1983-09-01T00:00:001983The muc genes of pKM101 are induced by DNA damage.7880532Elledge SJ, Harper JWCurrent opinion in cell biologyCdk inhibitors: on the threshold of checkpoints and development. Curr Opin Cell Biol. 1994 Dec; 6(6):847-52.Curr Opin Cell Biol1994-12-01T00:00:001994Cdk inhibitors: on the threshold of checkpoints and development.7957921Pearlman JA, Powaser PA, Elledge SJ, Caskey CTFEBS lettersTroponin T is capable of binding dystrophin via a leucine zipper. FEBS Lett. 1994 Nov 07; 354(2):183-6.FEBS Lett1994-11-07T00:00:001994Troponin T is capable of binding dystrophin via a leucine zipper.14766969Tetzlaff MT, Yu W, Li M, Zhang P, Finegold M, Mahon K, Harper JW, Schwartz RJ, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaDefective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A. 2004 Mar 09; 101(10):3338-45.Proc Natl Acad Sci U S A2004-02-06T00:00:002004Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein.7525595Durfee T, Mancini MA, Jones D, Elledge SJ, Lee WHThe Journal of cell biologyThe amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing. J Cell Biol. 1994 Nov; 127(3):609-22.J Cell Biol1994-11-01T00:00:001994The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing.7585563Eastham JA, Hall SJ, Sehgal I, Wang J, Timme TL, Yang G, Connell-Crowley L, Elledge SJ, Zhang WW, Harper JWCancer researchIn vivo gene therapy with p53 or p21 adenovirus for prostate cancer. Cancer Res. 1995 Nov 15; 55(22):5151-5.Cancer Res1995-11-15T00:00:001995In vivo gene therapy with p53 or p21 adenovirus for prostate cancer.7664346Deng C, Zhang P, Harper JW, Elledge SJ, Leder PCellMice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell. 1995 Aug 25; 82(4):675-84.Cell1995-08-25T00:00:001995Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control.6287997Walker GC, Kenyon CJ, Bagg A, Elledge SJ, Perry KL, Shanabruch WGBasic life sciencesRegulation and functions of Escherichia coli genes induced by DNA damage. Basic Life Sci. 1982; 20:43-63.Basic Life Sci1982-01-01T00:00:001982Regulation and functions of Escherichia coli genes induced by DNA damage.6340657Walker GC, Elledge SJ, Perry KL, Bagg A, Kenyon CJBasic life sciencesRegulation and function of cellular gene products involved in UV and chemical mutagenesis in E. coli. Basic Life Sci. 1983; 23:181-202.Basic Life Sci1983-01-01T00:00:001983Regulation and function of cellular gene products involved in UV and chemical mutagenesis in E. coli.7729684Matsuoka S, Edwards MC, Bai C, Parker S, Zhang P, Baldini A, Harper JW, Elledge SJGenes & developmentp57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev. 1995 Mar 15; 9(6):650-62.Genes Dev1995-03-15T00:00:001995p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.Authorship 12008417443180Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJNatureAnaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature. 2007 Apr 19; 446(7138):876-81.Nature2007-04-19T00:00:002007Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.18948746Li JM, Tetzlaff MT, Elledge SJCell cycle (Georgetown, Tex.)Identification of MSA1, a cell cycle-regulated, dosage suppressor of drc1/sld2 and dpb11 mutants. Cell Cycle. 2008 Nov 01; 7(21):3388-98.Cell Cycle2008-11-01T00:00:002008Identification of MSA1, a cell cycle-regulated, dosage suppressor of drc1/sld2 and dpb11 mutants.19261749Wang B, Hurov K, Hofmann K, Elledge SJGenes & developmentNBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev. 2009 Mar 15; 23(6):729-39.Genes Dev2009-03-04T00:00:002009NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.2523839Elledge SJ, Davis RWGenes & developmentPosition and density effects on repression by stationary and mobile DNA-binding proteins. Genes Dev. 1989 Feb; 3(2):185-97.Genes Dev1989-02-01T00:00:001989Position and density effects on repression by stationary and mobile DNA-binding proteins.20937877Chou DM, Adamson B, Dephoure NE, Tan X, Nottke AC, Hurov KE, Gygi SP, Colaiácovo MP, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaA chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43):18475-80.Proc Natl Acad Sci U S A2010-10-11T00:00:002010A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage.3063604Elledge SJ, Davis RWGeneA family of versatile centromeric vectors designed for use in the sectoring-shuffle mutagenesis assay in Saccharomyces cerevisiae. Gene. 1988 Oct 30; 70(2):303-12.Gene1988-10-30T00:00:001988A family of versatile centromeric vectors designed for use in the sectoring-shuffle mutagenesis assay in Saccharomyces cerevisiae.8261511Zhou Z, Elledge SJCellDUN1 encodes a protein kinase that controls the DNA damage response in yeast. Cell. 1993 Dec 17; 75(6):1119-27.Cell1993-12-17T00:00:001993DUN1 encodes a protein kinase that controls the DNA damage response in yeast.9925645Zhang P, Wong C, Liu D, Finegold M, Harper JW, Elledge SJGenes & developmentp21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step. Genes Dev. 1999 Jan 15; 13(2):213-24.Genes Dev1999-01-15T00:00:001999p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step.11733064Hu F, Wang Y, Liu D, Li Y, Qin J, Elledge SJCellRegulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints. Cell. 2001 Nov 30; 107(5):655-65.Cell2001-11-30T00:00:002001Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints.11961546Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NPNatureStructure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature. 2002 Apr 18; 416(6882):703-9.Nature2002-04-18T00:00:002002Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.Authorship 110629512791985Zou L, Elledge SJScience (New York, N.Y.)Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science. 2003 Jun 06; 300(5625):1542-8.Science2003-06-06T00:00:002003Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.13679922Xu L, Wei Y, Reboul J, Vaglio P, Shin TH, Vidal M, Elledge SJ, Harper JWNatureBTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature. 2003 Sep 18; 425(6955):316-21.Nature2003-09-03T00:00:002003BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.2023-12-31ELLEDGE, STEPHEN J2019-01-01Analysis of the Mammalian DNA Damage ResponseR01CA234600Principal Investigator16319895Turnell AS, Stewart GS, Grand RJ, Rookes SM, Martin A, Yamano H, Elledge SJ, Gallimore PHNatureThe APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression. Nature. 2005 Dec 01; 438(7068):690-5.Nature2005-12-01T00:00:002005The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression.17889643Solimini NL, Luo J, Elledge SJCellNon-oncogene addiction and the stress phenotype of cancer cells. Cell. 2007 Sep 21; 130(6):986-8.Cell2007-09-21T00:00:002007Non-oncogene addiction and the stress phenotype of cancer cells.19092802Xiao A, Li H, Shechter D, Ahn SH, Fabrizio LA, Erdjument-Bromage H, Ishibe-Murakami S, Wang B, Tempst P, Hofmann K, Patel DJ, Elledge SJ, Allis CDNatureWSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature. 2009 Jan 01; 457(7225):57-62.Nature2008-12-17T00:00:002008WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.2685561Elledge SJ, Davis RWMolecular and cellular biologyIdentification of the DNA damage-responsive element of RNR2 and evidence that four distinct cellular factors bind it. Mol Cell Biol. 1989 Dec; 9(12):5373-86.Mol Cell Biol1989-12-01T00:00:001989Identification of the DNA damage-responsive element of RNR2 and evidence that four distinct cellular factors bind it.21179023Kapitzky L, Beltrao P, Berens TJ, Gassner N, Zhou C, Wüster A, Wu J, Babu MM, Elledge SJ, Toczyski D, Lokey RS, Krogan NJMolecular systems biologyCross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol. 2010 Dec 21; 6:451.Mol Syst Biol2010-12-21T00:00:002010Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action.21307310Meerbrey KL, Hu G, Kessler JD, Roarty K, Li MZ, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, Schiff R, Rosen JM, Westbrook TF, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaThe pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proc Natl Acad Sci U S A. 2011 Mar 01; 108(9):3665-70.Proc Natl Acad Sci U S A2011-02-09T00:00:002011The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo.23503679Zhu J, Larman HB, Gao G, Somwar R, Zhang Z, Laserson U, Ciccia A, Pavlova N, Church G, Zhang W, Kesari S, Elledge SJNature biotechnologyProtein interaction discovery using parallel analysis of translated ORFs (PLATO). Nat Biotechnol. 2013 Apr; 31(4):331-334.Nat Biotechnol2013-03-17T00:00:002013Protein interaction discovery using parallel analysis of translated ORFs (PLATO).Authorship 11290227Authorship 11295471430709805Maertens O, Kuzmickas R, Manchester HE, Emerson CE, Gavin AG, Guild CJ, Wong TC, De Raedt T, Bowman-Colin C, Hatchi E, Garraway LA, Flaherty KT, Pathania S, Elledge SJ, Cichowski KCancer discoveryMAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas. Cancer Discov. 2019 04; 9(4):526-545.Cancer Discov2019-02-01T00:00:002019MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas.30686591Mengwasser KE, Adeyemi RO, Leng Y, Choi MY, Clairmont C, D'Andrea AD, Elledge SJMolecular cellGenetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. Mol Cell. 2019 03 07; 73(5):885-899.e6.Mol Cell2019-01-24T00:00:002019Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets.Authorship 13402515Authorship 1215141Authorship 11384812Authorship 11394743Authorship 122647330872507Haigis KM, Cichowski K, Elledge SJScience (New York, N.Y.)Tissue-specificity in cancer: The rule, not the exception. Science. 2019 Mar 15; 363(6432):1150-1151.Science2019-03-15T00:00:002019Tissue-specificity in cancer: The rule, not the exception.30849392Barber KW, Elledge SJMolecular cellSequencer Hacking Unlocks Quantitative Protein Studies. Mol Cell. 2019 03 07; 73(5):863-865.Mol Cell2019-03-07T00:00:002019Sequencer Hacking Unlocks Quantitative Protein Studies.D029701Chemicals & Drugs52618840.48734Saccharomyces cerevisiae ProteinsD004249Disorders99324190.475972DNA DamageD002453Physiology120629600.530467Cell CycleD018797Chemicals & Drugs129934330.426598Cell Cycle ProteinsD004260Physiology79520300.495506DNA RepairAuthorship 11501661431042470Eshleman SH, Laeyendecker O, Kammers K, Chen A, Sivay MV, Kottapalli S, Sie BM, Yuan T, Monaco DR, Mohan D, Wansley D, Kula T, Morrison C, Elledge SJ, Brookmeyer R, Ruczinski I, Larman HBCell reportsComprehensive Profiling of HIV Antibody Evolution. Cell Rep. 2019 04 30; 27(5):1422-1433.e4.Cell Rep2019-04-30T00:00:002019Comprehensive Profiling of HIV Antibody Evolution.Cell BiologyGeneticsMedicineNeurobiologyObstetrics Gynecology & Repro. Bio.PathologyRadiation OncologySurgeryGeneticsBeth Israel Deaconess Medical CenterBrigham and Women's HospitalDana-Farber Cancer InstituteHarvard Medical SchoolMassachusetts General HospitalMEG15MarnieGelbartMarnie Gelbart, Ph.D.42.33837200000000-71.1032690000000074104Gelbart, MarnieResearch Associate in GeneticsAuthorship 1153801731085644Isnard P, Kula T, Avettand Fenoel V, Anglicheau D, Terzi F, Legendre C, Elledge SJ, Canaud GProceedings of the National Academy of Sciences of the United States of AmericaTemporal virus serological profiling of kidney graft recipients using VirScan. Proc Natl Acad Sci U S A. 2019 05 28; 116(22):10899-10904.Proc Natl Acad Sci U S A2019-05-13T00:00:002019Temporal virus serological profiling of kidney graft recipients using VirScan.ABS4AnneGierschAnne B.S. Giersch, Ph.D.42.33837200000000-71.1032690000000053534Giersch, AnneAssistant Professor of PathologyKS26KevinStruhlKevin Struhl, Ph.D.42.33588600000000-71.1051460000000013584Struhl, KevinDavid Wesley Gaiser Professor of Biological Chemistry and Molecular Pharmacology11386selected publications7.251740.002473261154research areas2.234030.00473243141coauthor of224.83460.415160similar toAuthorship 12214426SPG4StevenGygiSteven P. Gygi, Ph.D.42.33588600000000-71.1051460000000028969Gygi, StevenProfessor of Cell BiologyCCM2CynthiaMortonCynthia Casson Morton, Ph.D.42.33837200000000-71.1032690000000049558Morton, CynthiaWilliam Lambert Richardson Professor of Obstetrics, Gynecology and Reproductive BiologyMK60MelanieKucherlapatiMelanie Haas Kucherlapati, Ph.D.42.33837200000000-71.1032690000000027570Kucherlapati, MelanieInstructor in MedicineAuthorship 1163111931186276Bender Ignacio RA, Dasgupta S, Stevens-Ayers T, Kula T, Hill JA, Lee SJ, Mielcarek M, Duerr A, Elledge SJ, Boeckh MBloodComprehensive viromewide antibody responses by systematic epitope scanning after hematopoietic cell transplantation. Blood. 2019 08 08; 134(6):503-514.Blood2019-06-11T00:00:002019Comprehensive viromewide antibody responses by systematic epitope scanning after hematopoietic cell transplantation.MBY1MichaelYaffeMichael Bruce Yaffe, M.D., Ph.D.42.36019290000000-71.0916066000000026854Yaffe, MichaelInstructor in SurgeryAEE3Andrew EugeneEliaAndrew Eugene Hermann Elia, M.D., Ph.D.42.33510370000000-71.1061649000000040504Elia, Andrew EugeneAssistant Professor of Radiation OncologyRK35RajuKucherlapatiRaju Kucherlapati, Ph.D.42.33837200000000-71.1032690000000036496Kucherlapati, RajuPaul C. Cabot Professor of GeneticsJWH11WadeHarperWade Harper, Ph.D.42.33837200000000-71.1032690000000020290Harper, WadeBert and Natalie Vallee Professor of Molecular PathologyADD1AlanD'AndreaAlan David D'Andrea, M.D.42.33789600000000-71.1072493000000082644D'Andrea, AlanAlvan T. and Viola D. Fuller American Cancer Society Professor of Radiation OncologyNP7NorbertPerrimonNorbert Perrimon, Ph.D.42.33837200000000-71.103269000000006247Perrimon, NorbertJames Stillman Professor of Developmental BiologyAuthorship 11681606Authorship 1169199831262815Zirin J, Ni X, Sack LM, Yang-Zhou D, Hu Y, Brathwaite R, Bulyk ML, Elledge SJ, Perrimon NProceedings of the National Academy of Sciences of the United States of AmericaInterspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells. Proc Natl Acad Sci U S A. 2019 07 16; 116(29):14614-14619.Proc Natl Acad Sci U S A2019-07-01T00:00:002019Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells.31273098Timms RT, Zhang Z, Rhee DY, Harper JW, Koren I, Elledge SJScience (New York, N.Y.)A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation. Science. 2019 07 05; 365(6448).Science2019-07-05T00:00:002019A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation.Authorship 1282962Authorship 117759713Authorship 11769811131358949Harrison GF, Sanz J, Boulais J, Mina MJ, Grenier JC, Leng Y, Dumaine A, Yotova V, Bergey CM, Nsobya SL, Elledge SJ, Schurr E, Quintana-Murci L, Perry GH, Barreiro LBNature ecology & evolutionNatural selection contributed to immunological differences between hunter-gatherers and agriculturalists. Nat Ecol Evol. 2019 08; 3(8):1253-1264.Nat Ecol Evol2019-07-29T00:00:002019Natural selection contributed to immunological differences between hunter-gatherers and agriculturalists.31352533Irving AT, Rozario P, Kong PS, Luko K, Gorman JJ, Hastie ML, Chia WN, Mani S, Lee BP, Smith GJD, Mendenhall IH, Larman HB, Elledge SJ, Wang LFCellular and molecular life sciences : CMLSRobust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia. Cell Mol Life Sci. 2020 Apr; 77(8):1607-1622.Cell Mol Life Sci2019-07-27T00:00:002019Robust dengue virus infection in bat cells and limited innate immune responses coupled with positive serology from bats in IndoMalaya and Australasia.31398327Kula T, Dezfulian MH, Wang CI, Abdelfattah NS, Hartman ZC, Wucherpfennig KW, Lyerly HK, Elledge SJCellT-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. Cell. 2019 08 08; 178(4):1016-1028.e13.Cell2019-08-08T00:00:002019T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes.Authorship 11787628Authorship 1509243Authorship 14620419Authorship 11904171131494268Kong W, Hayashi T, Fiches G, Xu Q, Li MZ, Que J, Liu S, Zhang W, Qi J, Santoso N, Elledge SJ, Zhu JGenomics, proteomics & bioinformaticsDiversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions. Genomics Proteomics Bioinformatics. 2019 06; 17(3):319-331.Genomics Proteomics Bioinformatics2019-09-05T00:00:002019Diversified Application of Barcoded PLATO (PLATO-BC) Platform for Identification of Protein Interactions.Authorship 1501638Authorship 1193233631553912Elman JS, Ni TK, Mengwasser KE, Jin D, Wronski A, Elledge SJ, Kuperwasser CCell reportsIdentification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing. Cell Rep. 2019 09 24; 28(13):3435-3449.e5.Cell Rep2019-09-24T00:00:002019Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.Authorship 1190694Authorship 12003701531672891Mina MJ, Kula T, Leng Y, Li M, de Vries RD, Knip M, Siljander H, Rewers M, Choy DF, Wilson MS, Larman HB, Nelson AN, Griffin DE, de Swart RL, Elledge SJScience (New York, N.Y.)Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens. Science. 2019 11 01; 366(6465):599-606.Science2019-11-01T00:00:002019Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens.Authorship 1205219731723608Heo JM, Harper NJ, Paulo JA, Li M, Xu Q, Coughlin M, Elledge SJ, Harper JWScience advancesIntegrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy. Sci Adv. 2019 11; 5(11):eaay4624.Sci Adv2019-11-06T00:00:002019Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy.true1Instructor in MedicineInstructor in Medicinetrue1Instructor in SurgeryInstructor in Surgerytrue1Assistant Professor of PathologyAssistant Professor of Pathologytrue1James Stillman Professor of Developmental BiologyJames Stillman Professor of Developmental BiologyAuthorship 1588689Authorship 1225758732041867Bruno PM, Lu M, Dennis KA, Inam H, Moore CJ, Sheehe J, Elledge SJ, Hemann MT, Pritchard JRProceedings of the National Academy of Sciences of the United States of AmericaThe primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning. Proc Natl Acad Sci U S A. 2020 02 25; 117(8):4053-4060.Proc Natl Acad Sci U S A2020-02-10T00:00:002020The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning.Authorship 1693842Authorship 12364701432243838Guerra SL, Maertens O, Kuzmickas R, De Raedt T, Adeyemi RO, Guild CJ, Guillemette S, Redig AJ, Chambers ES, Xu M, Tiv H, Santagata S, Jänne PA, Elledge SJ, Cichowski KCancer cellA Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers. Cancer Cell. 2020 05 11; 37(5):705-719.e6.Cancer Cell2020-04-02T00:00:002020A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers.Authorship 1887882Authorship 1317134Authorship 178153Authorship 1248382932386318Quiat D, Kula T, Shimizu C, Kanegaye JT, Tremoulet AH, Pitkowsky Z, Son M, Newburger JW, Elledge SJ, Burns JCThe Journal of infectious diseasesHigh-Throughput Screening of Kawasaki Disease Sera for Antiviral Antibodies. J Infect Dis. 2020 11 09; 222(11):1853-1857.J Infect Dis2020-11-09T00:00:002020High-Throughput Screening of Kawasaki Disease Sera for Antiviral Antibodies.Authorship 1843374Authorship 13811515Authorship 1791981Authorship 1474827Authorship 1844541Authorship 1986474Authorship 1413063Authorship 1506335Authorship 1765868true1Professor of Cell BiologyProfessor of Cell BiologyAuthorship 1339415true1David Wesley Gaiser Professor of Biological Chemistry and Molecular PharmacologyDavid Wesley Gaiser Professor of Biological Chemistry and Molecular PharmacologyBCMPAuthorship 147479232994364Shrock E, Fujimura E, Kula T, Timms RT, Lee IH, Leng Y, Robinson ML, Sie BM, Li MZ, Chen Y, Logue J, Zuiani A, McCulloch D, Lelis FJN, Henson S, Monaco DR, Travers M, Habibi S, Clarke WA, Caturegli P, Laeyendecker O, Piechocka-Trocha A, Li JZ, Khatri A, Chu HY, Villani AC, Kays K, Goldberg MB, Hacohen N, Filbin MR, Yu XG, Walker BD, Wesemann DR, Larman HB, Lederer JA, Elledge SJScience (New York, N.Y.)Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity. Science. 2020 11 27; 370(6520).Science2020-09-29T00:00:002020Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity.Authorship 129221037Authorship 1448557Authorship 1305490333186527Kohlgruber AC, Wang CI, Elledge SJCellSome Like It Sweet: Dendritic Cells Add Sugar to Their T(ea). Cell. 2020 11 12; 183(4):847-849.Cell2020-11-12T00:00:002020Some Like It Sweet: Dendritic Cells Add Sugar to Their T(ea).Authorship 13152202633354688Morgenlander W, Henson S, Monaco D, Chen A, Littlefield K, Bloch EM, Fujimura E, Ruczinski I, Crowley AR, Natarajan H, Butler SE, Weiner JA, Li MZ, Bonny TS, Benner SE, Sullivan D, Shoham S, Quinn TC, Eshleman S, Casadevall A, Redd AD, Laeyendecker O, Ackerman ME, Pekosz A, Elledge SJ, Robinson M, Tobian AAR, Larman HBmedRxiv : the preprint server for health sciencesAntibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality. medRxiv. 2020 Dec 18.medRxiv2020-12-18T00:00:002020Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality.Authorship 14996811Authorship 13166321633414220Biering SB, Akey DL, Wong MP, Brown WC, Lo NTN, Puerta-Guardo H, Tramontini Gomes de Sousa F, Wang C, Konwerski JR, Espinosa DA, Bockhaus NJ, Glasner DR, Li J, Blanc SF, Juan EY, Elledge SJ, Mina MJ, Beatty PR, Smith JL, Harris EScience (New York, N.Y.)Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction. Science. 2021 01 08; 371(6525):194-200.Science2021-01-08T00:00:002021Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction.Authorship 132836411Authorship 13293482633567269Tokheim C, Wang X, Timms RT, Zhang B, Mena EL, Wang B, Chen C, Ge J, Chu J, Zhang W, Elledge SJ, Brown M, Liu XSMolecular cellSystematic characterization of mutations altering protein degradation in human cancers. Mol Cell. 2021 03 18; 81(6):1292-1308.e11.Mol Cell2021-02-09T00:00:002021Systematic characterization of mutations altering protein degradation in human cancers.33571169Morgenlander WR, Henson SN, Monaco DR, Chen A, Littlefield K, Bloch EM, Fujimura E, Ruczinski I, Crowley AR, Natarajan H, Butler SE, Weiner JA, Li MZ, Bonny TS, Benner SE, Balagopal A, Sullivan D, Shoham S, Quinn TC, Eshleman SH, Casadevall A, Redd AD, Laeyendecker O, Ackerman ME, Pekosz A, Elledge SJ, Robinson M, Tobian AA, Larman HBThe Journal of clinical investigationAntibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality. J Clin Invest. 2021 04 01; 131(7).J Clin Invest2021-04-01T00:00:002021Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality.Authorship 221281Authorship 152256TK141TomaszKulaTomasz Kula, Ph.D.96513Kula, TomaszResearch Fellow in Neurobiology (NPD)Authorship 13375011933707234Kumar S, Zeng Z, Bagati A, Tay RE, Sanz LA, Hartono SR, Ito Y, Abderazzaq F, Hatchi E, Jiang P, Cartwright ANR, Olawoyin O, Mathewson ND, Pyrdol JW, Li MZ, Doench JG, Booker MA, Tolstorukov MY, Elledge SJ, Chédin F, Liu XS, Wucherpfennig KWCancer discoveryCARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor Cells and T Cells. Cancer Discov. 2021 08; 11(8):2050-2071.Cancer Discov2021-03-11T00:00:002021CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor Cells and T Cells.Authorship 134355810Authorship 13452291633827988Mena EL, Donahue CJ, Vaites LP, Li J, Rona G, O'Leary C, Lignitto L, Miwatani-Minter B, Paulo JA, Dhabaria A, Ueberheide B, Gygi SP, Pagano M, Harper JW, Davey RA, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection. Proc Natl Acad Sci U S A. 2021 04 27; 118(17).Proc Natl Acad Sci U S A2021-04-27T00:00:002021ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.33831416Zheng S, Matthews AJ, Rahman N, Herrick-Reynolds K, Sible E, Choi JE, Wishnie A, Ng YK, Rhodes D, Elledge SJ, Vuong BQThe Journal of biological chemistryThe uncharacterized SANT and BTB domain-containing protein SANBR inhibits class switch recombination. J Biol Chem. 2021 Jan-Jun; 296:100625.J Biol Chem2021-04-06T00:00:002021The uncharacterized SANT and BTB domain-containing protein SANBR inhibits class switch recombination.Authorship 13515061433907750Patten JJ, Keiser PT, Gysi D, Menichetti G, Mori H, Donahue CJ, Gan X, do Valle I, Geoghegan-Barek K, Anantpadma M, Boytz R, Berrigan JL, Hulsey-Stubbs S, Ayazika T, O'Leary C, Jalloh S, Wagner F, Ayehunie S, Elledge SJ, Anderson D, Loscalzo J, Zitnik M, Gummuluru S, Namchuk MN, Barabási AL, Davey RAbioRxiv : the preprint server for biologyIdentification of druggable host targets needed for SARS-CoV-2 infection by combined pharmacological evaluation and cellular network directed prioritization both in vitro and in vivo. bioRxiv. 2022 Feb 01.bioRxiv2022-02-01T00:00:002022Identification of druggable host targets needed for SARS-CoV-2 infection by combined pharmacological evaluation and cellular network directed prioritization both in vitro and in vivo.33915088Lee Y, Kim J, Kim MS, Kwon Y, Shin S, Yi H, Kim H, Chang MJ, Chang CB, Kang SB, Kim VN, Kim JH, Kim JS, Elledge SJ, Kang CDevelopmental cellCoordinate regulation of the senescent state by selective autophagy. Dev Cell. 2021 05 17; 56(10):1512-1525.e7.Dev Cell2021-04-28T00:00:002021Coordinate regulation of the senescent state by selective autophagy.Authorship 1733836Authorship 1386515334390675Barber KW, Shrock E, Elledge SJMolecular cellCRISPR-based peptide library display and programmable microarray self-assembly for rapid quantitative protein binding assays. Mol Cell. 2021 Sep 02; 81(17):3650-3658.e5.Mol Cell2021-08-13T00:00:002021CRISPR-based peptide library display and programmable microarray self-assembly for rapid quantitative protein binding assays.Authorship 16518212Authorship 1394448934529489Martin TD, Patel RS, Cook DR, Choi MY, Patil A, Liang AC, Li MZ, Haigis KM, Elledge SJScience (New York, N.Y.)The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation. Science. 2021 Sep 17; 373(6561):1327-1335.Science2021-09-16T00:00:002021The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation.Authorship 1400836934597596Adeyemi RO, Willis NA, Elia AEH, Clairmont C, Li S, Wu X, D'Andrea AD, Scully R, Elledge SJMolecular cellThe Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair. Mol Cell. 2021 Nov 04; 81(21):4440-4456.e7.Mol Cell2021-09-30T00:00:002021The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.34711655Naxerova K, Di Stefano B, Makofske JL, Watson EV, de Kort MA, Martin TD, Dezfulian M, Ricken D, Wooten EC, Kuroda MI, Hochedlinger K, Elledge SJGenes & developmentIntegrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior. Genes Dev. 2021 11 01; 35(21-22):1527-1547.Genes Dev2021-10-28T00:00:002021Integrated loss- and gain-of-function screens define a core network governing human embryonic stem cell behavior.Authorship 14068151234789550Meng Q, Xie S, Gray GK, Dezfulian MH, Li W, Huang L, Akshinthala D, Ferrer E, Conahan C, Perea Del Pino S, Grossman J, Elledge SJ, Hidalgo M, Muthuswamy SKJournal for immunotherapy of cancerEmpirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids. J Immunother Cancer. 2021 11; 9(11).J Immunother Cancer2021-11-01T00:00:002021Empirical identification and validation of tumor-targeting T cell receptors from circulation using autologous pancreatic tumor organoids.Authorship 141092812Authorship 14151401334755130Chen G, Shrock EL, Li MZ, Spergel JM, Nadeau KC, Pongracic JA, Umetsu DT, Rachid R, MacGinnitie AJ, Phipatanakul W, Schneider L, Oettgen HC, Elledge SJCell reports. MedicineHigh-resolution epitope mapping by AllerScan reveals relationships between IgE and IgG repertoires during peanut oral immunotherapy. Cell Rep Med. 2021 10 19; 2(10):100410.Cell Rep Med2021-10-19T00:00:002021High-resolution epitope mapping by AllerScan reveals relationships between IgE and IgG repertoires during peanut oral immunotherapy.Authorship 20022835042811Guo XJ, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaV-CARMA: A tool for the detection and modification of antigen-specific T cells. Proc Natl Acad Sci U S A. 2022 01 25; 119(4).Proc Natl Acad Sci U S A2022-01-25T00:00:002022V-CARMA: A tool for the detection and modification of antigen-specific T cells.35017504Patel RS, Romero R, Watson EV, Liang AC, Burger M, Westcott PMK, Mercer KL, Bronson RT, Wooten EC, Bhutkar A, Jacks T, Elledge SJNature communicationsA GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells. Nat Commun. 2022 01 11; 13(1):256.Nat Commun2022-01-11T00:00:002022A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells.35025605Bjornevik K, Cortese M, Healy BC, Kuhle J, Mina MJ, Leng Y, Elledge SJ, Niebuhr DW, Scher AI, Munger KL, Ascherio AScience (New York, N.Y.)Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis. Science. 2022 01 21; 375(6578):296-301.Science2022-01-13T00:00:002022Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis.35013224Li S, Qian N, Jiang C, Zu W, Liang A, Li M, Elledge SJ, Tan XNature communicationsGain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation. Nat Commun. 2022 01 10; 13(1):105.Nat Commun2022-01-10T00:00:002022Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation.Authorship 14245807Authorship 142460812Authorship 14262307Authorship 1427297235148840Borriello F, Poli V, Shrock E, Spreafico R, Liu X, Pishesha N, Carpenet C, Chou J, Di Gioia M, McGrath ME, Dillen CA, Barrett NA, Lacanfora L, Franco ME, Marongiu L, Iwakura Y, Pucci F, Kruppa MD, Ma Z, Lowman DW, Ensley HE, Nanishi E, Saito Y, O'Meara TR, Seo HS, Dhe-Paganon S, Dowling DJ, Frieman M, Elledge SJ, Levy O, Irvine DJ, Ploegh HL, Williams DL, Zanoni ICellAn adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity. Cell. 2022 02 17; 185(4):614-629.e21.Cell2022-02-10T00:00:002022An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity.Authorship 14305017Authorship 143136029Authorship 14303731935149558Oreskovic E, Wheeler EC, Mengwasser KE, Fujimura E, Martin TD, Tothova Z, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaGenetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1. Proc Natl Acad Sci U S A. 2022 02 15; 119(7).Proc Natl Acad Sci U S A2022-02-15T00:00:002022Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1.Authorship 2430763Authorship 2506069Authorship 255578Authorship 280515Authorship 32915713Authorship 3541714Authorship 1599793Authorship 3959081Authorship 402501Authorship 4054303Authorship 149223419Authorship 14935993Authorship 1491437335937932Shrock EL, Shrock CL, Elledge SJBio-protocolVirScan: High-throughput Profiling of Antiviral Antibody Epitopes. Bio Protoc. 2022 Jul 05; 12(13).Bio Protoc2022-07-05T00:00:002022VirScan: High-throughput Profiling of Antiviral Antibody Epitopes.35992305Patten JJ, Keiser PT, Morselli-Gysi D, Menichetti G, Mori H, Donahue CJ, Gan X, Valle ID, Geoghegan-Barek K, Anantpadma M, Boytz R, Berrigan JL, Stubbs SH, Ayazika T, O'Leary C, Jalloh S, Wagner F, Ayehunie S, Elledge SJ, Anderson D, Loscalzo J, Zitnik M, Gummuluru S, Namchuk MN, Barabási AL, Davey RAiScienceIdentification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization. iScience. 2022 Sep 16; 25(9):104925.iScience2022-08-13T00:00:002022Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization.36313802Barber KW, Shrock E, Elledge SJCell reports methodsCasPlay provides a gRNA-barcoded CRISPR-based display platform for antibody repertoire profiling. Cell Rep Methods. 2022 10 24; 2(10):100318.Cell Rep Methods2022-10-17T00:00:002022CasPlay provides a gRNA-barcoded CRISPR-based display platform for antibody repertoire profiling.Authorship 151395212Authorship 1511892836593401Bruno PM, Timms RT, Abdelfattah NS, Leng Y, Lelis FJN, Wesemann DR, Yu XG, Elledge SJNature biotechnologyHigh-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform. Nat Biotechnol. 2023 Jul; 41(7):980-992.Nat Biotechnol2023-01-02T00:00:002023High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform.36608670Nardone C, Palanski BA, Scott DC, Timms RT, Barber KW, Gu X, Mao A, Leng Y, Watson EV, Schulman BA, Cole PA, Elledge SJMolecular cellA central role for regulated protein stability in the control of TFE3 and MITF by nutrients. Mol Cell. 2023 01 05; 83(1):57-73.e9.Mol Cell2023-01-05T00:00:002023A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.Authorship 2425562Authorship 15244621336805027Scott DC, King MT, Baek K, Gee CT, Kalathur R, Li J, Purser N, Nourse A, Chai SC, Vaithiyalingam S, Chen T, Lee RE, Elledge SJ, Kleiger G, Schulman BAMolecular cellE3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity. Mol Cell. 2023 03 02; 83(5):770-786.e9.Mol Cell2023-02-16T00:00:002023E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.Authorship 1776027Authorship 1937204Authorship 48424616Authorship 5120448Authorship 155953119Authorship 15632101Authorship 156465911Authorship 15600436Authorship 15642581237023193Shrock EL, Timms RT, Kula T, Mena EL, West AP, Guo R, Lee IH, Cohen AA, McKay LGA, Bi C, Leng Y, Fujimura E, Horns F, Li M, Wesemann DR, Griffiths A, Gewurz BE, Bjorkman PJ, Elledge SJScience (New York, N.Y.)Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses. Science. 2023 04 07; 380(6640):eadc9498.Science2023-04-07T00:00:002023Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses.37494473Mitchell MM, Leng Y, Boppana S, Britt WJ, Gutierrez Sanchez LH, Elledge SJScience translational medicineSignatures of AAV-2 immunity are enriched in children with severe acute hepatitis of unknown etiology. Sci Transl Med. 2023 07 26; 15(706):eadh9917.Sci Transl Med2023-07-26T00:00:002023Signatures of AAV-2 immunity are enriched in children with severe acute hepatitis of unknown etiology.37198482Lee JJ, Jung YL, Cheong TC, Espejo Valle-Inclan J, Chu C, Gulhan DC, Ljungström V, Jin H, Viswanadham VV, Watson EV, Cortés-Ciriano I, Elledge SJ, Chiarle R, Pellman D, Park PJNatureERa-associated translocations underlie oncogene amplifications in breast cancer. Nature. 2023 Jun; 618(7967):1024-1032.Nature2023-05-17T00:00:002023ERa-associated translocations underlie oncogene amplifications in breast cancer.37061980Elledge SJGenes & developmentAn Editor's rave review. Genes Dev. 2023 Jan 01; 37(1-2):18-19.Genes Dev2023-01-01T00:00:002023An Editor's rave review.37201526Makaros Y, Raiff A, Timms RT, Wagh AR, Gueta MI, Bekturova A, Guez-Haddad J, Brodsky S, Opatowsky Y, Glickman MH, Elledge SJ, Koren IMolecular cellUbiquitin-independent proteasomal degradation driven by C-degron pathways. Mol Cell. 2023 06 01; 83(11):1921-1935.e7.Mol Cell2023-05-17T00:00:002023Ubiquitin-independent proteasomal degradation driven by C-degron pathways.Authorship 2196522true1Assistant Professor of GeneticsAssistant Professor of GeneticsAuthorship 348826Authorship 158472011Authorship 15854755Authorship 15824637Authorship 158924222Authorship 1589518737577562Liebhoff AM, Venkataraman T, Morgenlander WR, Na M, Kula T, Waugh K, Morrison C, Rewers M, Longman R, Round J, Elledge S, Ruczinski I, Langmead B, Larman HBbioRxiv : the preprint server for biologyEfficient encoding of large antigenic spaces by epitope prioritization with Dolphyn. bioRxiv. 2023 Jul 31.bioRxiv2023-07-31T00:00:002023Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn.37616343Gu X, Nardone C, Kamitaki N, Mao A, Elledge SJ, Greenberg MEScience (New York, N.Y.)The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation. Science. 2023 08 25; 381(6660):eadh5021.Science2023-08-25T00:00:002023The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.37731906Edridge AWD, Abd-Elfarag G, Deijs M, Broeks MH, Cristella C, Sie B, Vaz FM, Jans JJM, Calis J, Verhoef H, Demir A, Poppert S, Nickel B, van Dam A, Sebit B, Titulaer MJ, Verweij JJ, de Jong MD, van Gool T, Faragher B, Verhoeven-Duif NM, Elledge SJ, van der Hoek L, Boele van Hensbroek MBrain communicationsParasitic, bacterial, viral, immune-mediated, metabolic and nutritional factors associated with nodding syndrome. Brain Commun. 2023; 5(5):fcad223.Brain Commun2023-08-17T00:00:002023Parasitic, bacterial, viral, immune-mediated, metabolic and nutritional factors associated with nodding syndrome.37735597Timms RT, Mena EL, Leng Y, Li MZ, Tchasovnikarova IA, Koren I, Elledge SJNature cell biologyDefining E3 ligase-substrate relationships through multiplex CRISPR screening. Nat Cell Biol. 2023 10; 25(10):1535-1545.Nat Cell Biol2023-09-21T00:00:002023Defining E3 ligase-substrate relationships through multiplex CRISPR screening.37738965Zhang Z, Sie B, Chang A, Leng Y, Nardone C, Timms RT, Elledge SJMolecular cellElucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping. Mol Cell. 2023 09 21; 83(18):3377-3392.e6.Mol Cell2023-09-21T00:00:002023Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping.Authorship 3899825true1Bert and Natalie Vallee Professor of Molecular PathologyBert and Natalie Vallee Professor of Molecular Pathologytrue1Research Fellow in MedicineResearch Fellow in Medicinetrue1Research Fellow in Neurobiology (NPD)Research Fellow in Neurobiology (NPD)true1William Lambert Richardson Professor of Obstetrics, Gynecology and Reproductive BiologyWilliam Lambert Richardson Professor of Obstetrics, Gynecology and Reproductive Biologytrue1Gregor Mendel Professor of Genetics and of MedicineGregor Mendel Professor of Genetics and of Medicine2Professor of MedicineProfessor of Medicinetrue1Research Associate in GeneticsResearch Associate in Geneticstrue1Paul C. Cabot Professor of GeneticsPaul C. Cabot Professor of Geneticstrue1Assistant Professor of Radiation OncologyAssistant Professor of Radiation OncologyAuthorship 4564242738016469Dezfulian MH, Kula T, Pranzatelli T, Kamitaki N, Meng Q, Khatri B, Perez P, Xu Q, Chang A, Kohlgruber AC, Leng Y, Jupudi AA, Joachims ML, Chiorini JA, Lessard CJ, Darise Farris A, Muthuswamy SK, Warner BM, Elledge SJCellTScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes. Cell. 2023 12 07; 186(25):5569-5586.e21.Cell2023-11-27T00:00:002023TScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes.Authorship 16075987Authorship 16114521937977122Zhang Z, Sie B, Chang A, Leng Y, Nardone C, Timms RT, Elledge SJMolecular cellElucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping. Mol Cell. 2023 Nov 16; 83(22):4191-4192.Mol Cell2023-11-16T00:00:002023Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping.Authorship 1614478738114738Timms RT, Mena EL, Leng Y, Li MZ, Tchasovnikarova IA, Koren I, Elledge SJNature cell biologyAuthor Correction: Defining E3 ligase-substrate relationships through multiplex CRISPR screening. Nat Cell Biol. 2024 Feb; 26(2):305.Nat Cell Biol2024-02-01T00:00:002024Author Correction: Defining E3 ligase-substrate relationships through multiplex CRISPR screening.Authorship 5358603Authorship 5707448true1Alvan T. and Viola D. Fuller American Cancer Society Professor of Radiation OncologyAlvan T. and Viola D. Fuller American Cancer Society Professor of Radiation Oncology38388848Watson EV, Lee JJ, Gulhan DC, Melloni GEM, Venev SV, Magesh RY, Frederick A, Chiba K, Wooten EC, Naxerova K, Dekker J, Park PJ, Elledge SJNature geneticsChromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns. Nat Genet. 2024 Feb 22.Nat Genet2024-02-22T00:00:002024Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns.Authorship 163317213Authorship 16329501138383452Liebhoff AM, Venkataraman T, Morgenlander WR, Na M, Kula T, Waugh K, Morrison C, Rewers M, Longman R, Round J, Elledge S, Ruczinski I, Langmead B, Larman HBNature communicationsEfficient encoding of large antigenic spaces by epitope prioritization with Dolphyn. Nat Commun. 2024 Feb 21; 15(1):1577.Nat Commun2024-02-21T00:00:002024Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn.Authorship 5292221Authorship 1561418Authorship 3631427Authorship 4039004Authorship 2375732Authorship 4326074Authorship 4440424Authorship 4589339Authorship 251651Authorship 2673602Authorship 3173114TDM4TimothyMartinTimothy Dean Martin, Ph.D.120374Martin, TimothyResearch Fellow in MedicineAuthorship 3520112Authorship 6501198Authorship 65638410Authorship 64657522Authorship 6681327Authorship 64455912Authorship 6634511623869001Altindis E, Alpar MA, Aksay E, Beckwith J, Bökel C, Curl RF, Darnell RB, Elledge SJ, Erman B, Frahm J, Goff SP, Greengard P, Hoffmann R, Ilhan B, Kaslin J, Lipkin SM, Poulopoulou C, Raz E, Rubin MA, Salturk M, Schrock RR, Trautmann A, Unutmaz D, Weinstein H, Kizil CScience (New York, N.Y.)Turkey must end violent response to protests. Science. 2013 Jul 19; 341(6143):236.Science2013-07-19T00:00:002013Turkey must end violent response to protests.23682311Pavlova NN, Pallasch C, Elia AE, Braun CJ, Westbrook TF, Hemann M, Elledge SJeLifeA role for PVRL4-driven cell-cell interactions in tumorigenesis. Elife. 2013 Apr 30; 2:e00358.Elife2013-04-30T00:00:002013A role for PVRL4-driven cell-cell interactions in tumorigenesis.23436801Liu Q, Xu C, Kirubakaran S, Zhang X, Hur W, Liu Y, Kwiatkowski NP, Wang J, Westover KD, Gao P, Ercan D, Niepel M, Thoreen CC, Kang SA, Patricelli MP, Wang Y, Tupper T, Altabef A, Kawamura H, Held KD, Chou DM, Elledge SJ, Janne PA, Wong KK, Sabatini DM, Gray NSCancer researchCharacterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR. Cancer Res. 2013 Apr 15; 73(8):2574-86.Cancer Res2013-02-22T00:00:002013Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.23497938Larman HB, Laserson U, Querol L, Verhaeghen K, Solimini NL, Xu GJ, Klarenbeek PL, Church GM, Hafler DA, Plenge RM, Nigrovic PA, De Jager PL, Weets I, Martens GA, O'Connor KC, Elledge SJJournal of autoimmunityPhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. J Autoimmun. 2013 Jun; 43:1-9.J Autoimmun2013-03-13T00:00:002013PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis.23596012Larman HB, Salajegheh M, Nazareno R, Lam T, Sauld J, Steen H, Kong SW, Pinkus JL, Amato AA, Elledge SJ, Greenberg SAAnnals of neurologyCytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis. Ann Neurol. 2013 Mar; 73(3):408-18.Ann Neurol2013-03-01T00:00:002013Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis.Authorship 1864572Authorship 5095387Authorship 5330921Authorship 1909207Authorship 678987724086134Finton KA, Larimore K, Larman HB, Friend D, Correnti C, Rupert PB, Elledge SJ, Greenberg PD, Strong RKPLoS pathogensAutoreactivity and exceptional CDR plasticity (but not unusual polyspecificity) hinder elicitation of the anti-HIV antibody 4E10. PLoS Pathog. 2013; 9(9):e1003639.PLoS Pathog2013-09-26T00:00:002013Autoreactivity and exceptional CDR plasticity (but not unusual polyspecificity) hinder elicitation of the anti-HIV antibody 4E10.Authorship 2750732Authorship 2013662Authorship 692188724183448Davoli T, Xu AW, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJCellCumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell. 2013 Nov 07; 155(4):948-62.Cell2013-10-31T00:00:002013Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome.Authorship 20631012Authorship 2244082Authorship 698833324336473Larman HB, Liang AC, Elledge SJ, Zhu JNature protocolsDiscovery of protein interactions using parallel analysis of translated ORFs (PLATO). Nat Protoc. 2014 Jan; 9(1):90-103.Nat Protoc2013-12-12T00:00:002013Discovery of protein interactions using parallel analysis of translated ORFs (PLATO).Authorship 1925902Authorship 7017451124268777Lin TY, Chin CR, Everitt AR, Clare S, Perreira JM, Savidis G, Aker AM, John SP, Sarlah D, Carreira EM, Elledge SJ, Kellam P, Brass ALCell reportsAmphotericin B increases influenza A virus infection by preventing IFITM3-mediated restriction. Cell Rep. 2013 Nov 27; 5(4):895-908.Cell Rep2013-11-21T00:00:002013Amphotericin B increases influenza A virus infection by preventing IFITM3-mediated restriction.Authorship 23892911Authorship 704443624439903Olive AJ, Haff MG, Emanuele MJ, Sack LM, Barker JR, Elledge SJ, Starnbach MNCell host & microbeChlamydia trachomatis-induced alterations in the host cell proteome are required for intracellular growth. Cell Host Microbe. 2014 Jan 15; 15(1):113-24.Cell Host Microbe2014-01-15T00:00:002014Chlamydia trachomatis-induced alterations in the host cell proteome are required for intracellular growth.Authorship 2721675Authorship 405642324556985Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaGLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10):3781-6.Proc Natl Acad Sci U S A2014-02-20T00:00:002014GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.Authorship 3077897KN52KamilaNaxerovaKamila Naxerova, Ph.D.33751Naxerova, KamilaAssistant Professor of GeneticsAuthorship 706102Authorship 2823063Authorship 2879982Authorship 7223177Authorship 72153415Authorship 7242561023765749Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DAStem cells (Dayton, Ohio)Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells. Stem Cells. 2013 Dec; 31(12):2833-41.Stem Cells2013-12-01T00:00:002013Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells.24658464Li J, Zhu S, Kozono D, Ng K, Futalan D, Shen Y, Akers JC, Steed T, Kushwaha D, Schlabach M, Carter BS, Kwon CH, Furnari F, Cavenee W, Elledge S, Chen CCOncotargetGenome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma. Oncotarget. 2014 Feb 28; 5(4):882-93.Oncotarget2014-02-28T00:00:002014Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma.Authorship 23111417Authorship 2524849Authorship 27524010Authorship 2854832Authorship 920163Authorship 18642711Authorship 742142925032616Kahle KT, Gao G, Zhang J, Latremoliere A, Andrews N, Shang Y, Alessi D, Woolf C, Elledge S, Clapham DNeurosurgeryRonald R. Tasker Young Investigator Award 165 Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity. Neurosurgery. 2014 Aug; 61 Suppl 1:214.Neurosurgery2014-08-01T00:00:002014Ronald R. Tasker Young Investigator Award 165 Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity.Authorship 3705194Authorship 3317243Authorship 2769636Authorship 2774415Authorship 3157713Authorship 3271802Authorship 3731141Authorship 4766063Authorship 55714919Authorship 3517013Authorship 3570559Authorship 3578344Authorship 7601652Authorship 7598581025276233Tan X, Elledge SJGenome medicineWhen noise makes music: HIV reactivation with transcriptional noise enhancers. Genome Med. 2014; 6(7):55.Genome Med2014-07-29T00:00:002014When noise makes music: HIV reactivation with transcriptional noise enhancers.25254371Finton KA, Friend D, Jaffe J, Gewe M, Holmes MA, Larman HB, Stuart A, Larimore K, Greenberg PD, Elledge SJ, Stamatatos L, Strong RKPLoS pathogensOntogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10. PLoS Pathog. 2014 Sep; 10(9):e1004403.PLoS Pathog2014-09-25T00:00:002014Ontogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10.Authorship 3882842Authorship 4017467Authorship 4311092Authorship 44978811Authorship 766104625347953Seo M, Lee S, Kim JH, Lee WH, Hu G, Elledge SJ, Suk KNature communicationsRNAi-based functional selection identifies novel cell migration determinants dependent on PI3K and AKT pathways. Nat Commun. 2014 Oct 28; 5:5217.Nat Commun2014-10-28T00:00:002014RNAi-based functional selection identifies novel cell migration determinants dependent on PI3K and AKT pathways.Authorship 7677101725373910Zhu J, Davoli T, Perriera JM, Chin CR, Gaiha GD, John SP, Sigiollot FD, Gao G, Xu Q, Qu H, Pertel T, Sims JS, Smith JA, Baker RE, Maranda L, Ng A, Elledge SJ, Brass ALCell reportsComprehensive identification of host modulators of HIV-1 replication using multiple orthologous RNAi reagents. Cell Rep. 2014 Oct 23; 9(2):752-66.Cell Rep2014-10-16T00:00:002014Comprehensive identification of host modulators of HIV-1 replication using multiple orthologous RNAi reagents.Authorship 4620792Authorship 2300101Authorship 771594625430771Wang R, Persky NS, Yoo B, Ouerfelli O, Smogorzewska A, Elledge SJ, Pavletich NPScience (New York, N.Y.)DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. Science. 2014 Nov 28; 346(6213):1127-30.Science2014-11-28T00:00:002014DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1.Authorship 4917912Authorship 52622Authorship 778205625512513Ciccia A, Huang JW, Izhar L, Sowa ME, Harper JW, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaTreacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18631-6.Proc Natl Acad Sci U S A2014-12-15T00:00:002014Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response.Authorship 4977434Authorship 565131225642963Ceccaldi R, Liu JC, Amunugama R, Hajdu I, Primack B, Petalcorin MI, O'Connor KW, Konstantinopoulos PA, Elledge SJ, Boulton SJ, Yusufzai T, D'Andrea ADNatureHomologous-recombination-deficient tumours are dependent on Pol?-mediated repair. Nature. 2015 Feb 12; 518(7538):258-62.Nature2015-02-02T00:00:002015Homologous-recombination-deficient tumours are dependent on Pol?-mediated repair.Authorship 2703543Authorship 2745006Authorship 2970158Authorship 3036185Authorship 5738425768301Gao J, Kim HM, Elia AE, Elledge SJ, Colaiácovo MPPLoS geneticsNatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis. PLoS Genet. 2015 Mar; 11(3):e1005029.PLoS Genet2015-03-13T00:00:002015NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis.Authorship 4003094Authorship 4208632Authorship 4143512Authorship 3339961Authorship 2629905Authorship 4417496Authorship 4499322Authorship 45245615Authorship 2652509Authorship 46813411Authorship 3671732Authorship 4731251Authorship 4771312Authorship 2089735Authorship 3855614Authorship 2231762Authorship 49138913Authorship 22467216Authorship 1644776Authorship 1741808Authorship 5567010Authorship 5604939Authorship 5639933Authorship 787415Authorship 2291617Authorship 440303Authorship 5053351Authorship 51265313Authorship 5594572Authorship 237239Authorship 2597491Authorship 639894Authorship 645872Authorship 645145Authorship 790665Authorship 987093Authorship 2983602Authorship 2652465Authorship 2531201Authorship 3422389Authorship 3424735Authorship 3751908Authorship 2772873Authorship 2970295Authorship 2150852Authorship 22100713Authorship 2549155Authorship 2189103Authorship 2198033Authorship 303655Authorship 31120411Authorship 3247837Authorship 3303799Authorship 1294465Authorship 3844657Authorship 316609Authorship 33140612Authorship 3785191Authorship 4182613Authorship 1428928Authorship 3488322Authorship 2108824Authorship 4510355Authorship 2873292Authorship 3168932Authorship 3302334Authorship 35194110Authorship 3606136Authorship 4075342Authorship 4233424Authorship 4807967Authorship 5194687Authorship 5248793Authorship 1575462Authorship 2935045Authorship 32116213Authorship 3644517Authorship 3893821Authorship 4124828Authorship 4134972Authorship 4388729Authorship 4834323Authorship 5198872Authorship 5432354Authorship 8066569Authorship 79529410Authorship 79635014Authorship 799440426004182Izhar L, Adamson B, Ciccia A, Lewis J, Pontano-Vaites L, Leng Y, Liang AC, Westbrook TF, Harper JW, Elledge SJCell reportsA Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors. Cell Rep. 2015 Jun 09; 11(9):1486-500.Cell Rep2015-05-21T00:00:002015A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors.26045439Xu GJ, Kula T, Xu Q, Li MZ, Vernon SD, Ndung'u T, Ruxrungtham K, Sanchez J, Brander C, Chung RT, O'Connor KC, Walker B, Larman HB, Elledge SJScience (New York, N.Y.)Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome. Science. 2015 Jun 05; 348(6239):aaa0698.Science2015-06-05T00:00:002015Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome.Authorship 2499451Authorship 26911810Authorship 35169913Authorship 3775422Authorship 4333564Authorship 45978711Authorship 4776968Authorship 374611Authorship 4760312Authorship 53482311Authorship 5585002Authorship 57534710Authorship 3124854Authorship 3201666Authorship 816807226194808Naxerova K, Elledge SJeLifeTaking the brakes off telomerase. Elife. 2015 Jul 21; 4.Elife2015-07-21T00:00:002015Taking the brakes off telomerase.Authorship 357106Authorship 4476757Authorship 5351788Authorship 5448772Authorship 18026510Authorship 83403010Authorship 8343171Authorship 833555126348099Elledge SJJAMAThe DNA Damage Response--Self-awareness for DNA: The 2015 Albert Lasker Basic Medical Research Award. JAMA. 2015 Sep 15; 314(11):1111-2.JAMA2015-09-15T00:00:002015The DNA Damage Response--Self-awareness for DNA: The 2015 Albert Lasker Basic Medical Research Award.26051181Elia AE, Boardman AP, Wang DC, Huttlin EL, Everley RA, Dephoure N, Zhou C, Koren I, Gygi SP, Elledge SJMolecular cellQuantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response. Mol Cell. 2015 Sep 03; 59(5):867-81.Mol Cell2015-06-04T00:00:002015Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response.26359977Elledge SJCellAccidents and Damage Control. Cell. 2015 Sep 10; 162(6):1196-200.Cell2015-09-10T00:00:002015Accidents and Damage Control.Authorship 8363881026404840Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJScience (New York, N.Y.)The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science. 2015 Sep 25; 349(6255):aaa5612.Science2015-09-25T00:00:002015The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.Authorship 8411491026474068Elia AE, Wang DC, Willis NA, Boardman AP, Hajdu I, Adeyemi RO, Lowry E, Gygi SP, Scully R, Elledge SJMolecular cellRFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks. Mol Cell. 2015 Oct 15; 60(2):280-93.Mol Cell2015-10-15T00:00:002015RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.Authorship 4590144Authorship 849892926378236Huang H, Santoso N, Power D, Simpson S, Dieringer M, Miao H, Gurova K, Giam CZ, Elledge SJ, Zhu JThe Journal of biological chemistryFACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency. J Biol Chem. 2015 Nov 06; 290(45):27297-27310.J Biol Chem2015-09-16T00:00:002015FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency.Authorship 4318266Authorship 8546691926651948Tripathi S, Pohl MO, Zhou Y, Rodriguez-Frandsen A, Wang G, Stein DA, Moulton HM, DeJesus P, Che J, Mulder LC, Yángüez E, Andenmatten D, Pache L, Manicassamy B, Albrecht RA, Gonzalez MG, Nguyen Q, Brass A, Elledge S, White M, Shapira S, Hacohen N, Karlas A, Meyer TF, Shales M, Gatorano A, Johnson JR, Jang G, Johnson T, Verschueren E, Sanders D, Krogan N, Shaw M, König R, Stertz S, García-Sastre A, Chanda SKCell host & microbeMeta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding. Cell Host Microbe. 2015 Dec 09; 18(6):723-35.Cell Host Microbe2015-12-09T00:00:002015Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.Authorship 4530971Authorship 863892526833729Wang Y, Xu Q, Sack L, Kang C, Elledge SJGenes & developmentA gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. Genes Dev. 2016 Feb 01; 30(3):293-306.Genes Dev2016-02-01T00:00:002016A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling.Authorship 3386102Authorship 3432629Authorship 1820594Authorship 880304227129029Kang C, Elledge SJAutophagyHow autophagy both activates and inhibits cellular senescence. Autophagy. 2016 05 03; 12(5):898-9.Autophagy2016-05-03T00:00:002016How autophagy both activates and inhibits cellular senescence.Authorship 4474152Authorship 8813471226947976Borkent M, Bennett BD, Lackford B, Bar-Nur O, Brumbaugh J, Wang L, Du Y, Fargo DC, Apostolou E, Cheloufi S, Maherali N, Elledge SJ, Hu G, Hochedlinger KStem cell reportsA Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2. Stem Cell Reports. 2016 05 10; 6(5):704-716.Stem Cell Reports2016-03-03T00:00:002016A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2.Authorship 78227Authorship 5755537Authorship 88945812Authorship 889926627298342Willis NA, Zhou C, Elia AE, Murray JM, Carr AM, Elledge SJ, Rhind NProceedings of the National Academy of Sciences of the United States of AmericaIdentification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks. Proc Natl Acad Sci U S A. 2016 06 28; 113(26):E3676-85.Proc Natl Acad Sci U S A2016-06-13T00:00:002016Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.27298372Zhou C, Elia AE, Naylor ML, Dephoure N, Ballif BA, Goel G, Xu Q, Ng A, Chou DM, Xavier RJ, Gygi SP, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaProfiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks. Proc Natl Acad Sci U S A. 2016 06 28; 113(26):E3667-75.Proc Natl Acad Sci U S A2016-06-13T00:00:002016Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks.2Assistant Professor6Fellow or Post Doc0Full Professor4Instructor5Other FacultyAuthorship 924648Authorship 5602972Authorship 677722Authorship 4899302Authorship 512001Authorship 5309527Authorship 54398112Authorship 5552242Authorship 5577693Authorship 5627252Authorship 5648286Authorship 67237Authorship 5252073Authorship 5720052011-07-31D'ANDREA, ALAN D.2005-08-31Centers for Medical Countermeasures Against RadiationU19AI0677512021-07-31HAIGIS, KEVIN MICHAEL2015-09-25A multi-faceted approach to identifying K-Ras synthetic lethal relationshipsU01CA1992521993-07-31ELLEDGE, STEPHEN J1991-08-01GENETIC MANIPULATION OF YEAST ARTIFICIAL CHROMOSOMESR21HG0004632021-05-31LARMAN, HARRY BENJAMIN2015-06-22Development of Highly Multiplex Antigen Specificity AssaysU24AI1186332018-06-30ELLEDGE, STEPHEN J1990-07-01Analysis of the Mammalian DNA Damage ResponseR01GM0446642013-07-31ELLEDGE, STEPHEN J2009-08-01A multiplex genome-wide shRNA screening platform for cancer-lethal gene discoveryR33CA1400392023-05-31HARPER, JEFFREY W1993-01-01Ubiquitin-mediated proteolysis and cell cycle controlR01AG0110852013-06-30ELLEDGE, STEPHEN J1990-07-01Genetics of Cell Cycle & DNA Damage Regulation in YeastR37GM044664Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorAuthorship 913605527402361Sack LM, Davoli T, Xu Q, Li MZ, Elledge SJG3 (Bethesda, Md.)Sources of Error in Mammalian Genetic Screens. G3 (Bethesda). 2016 09 08; 6(9):2781-90.G3 (Bethesda)2016-09-08T00:00:002016Sources of Error in Mammalian Genetic Screens.Authorship 3397532Authorship 3795037Authorship 3857474Authorship 4228843Authorship 4499793Authorship 484079Authorship 5151366Authorship 5310542Authorship 9342297Authorship 9339381727782176Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, Sun D, Elledge SJ, Alessi DR, Kahle KTScientific reportsFunctional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain. Sci Rep. 2016 10 26; 6:35986.Sci Rep2016-10-26T00:00:002016Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.27821747Xu GJ, Shah AA, Li MZ, Xu Q, Rosen A, Casciola-Rosen L, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaSystematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer. Proc Natl Acad Sci U S A. 2016 11 22; 113(47):E7526-E7534.Proc Natl Acad Sci U S A2016-11-07T00:00:002016Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer.Authorship 2532955Authorship 3233004Authorship 33250814Authorship 9491141128087713Davoli T, Mengwasser KE, Duan J, Chen T, Christensen C, Wooten EC, Anselmo AN, Li MZ, Wong KK, Kahle KT, Elledge SJGenes & developmentFunctional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover. Genes Dev. 2016 12 15; 30(24):2684-2695.Genes Dev2016-12-15T00:00:002016Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover.Authorship 50755014Authorship 5340622Authorship 5378086Authorship 953295428104840Davoli T, Uno H, Wooten EC, Elledge SJScience (New York, N.Y.)Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy. Science. 2017 01 20; 355(6322).Science2017-01-20T00:00:002017Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy.Authorship 6008212Authorship 957204628167502Liao S, Davoli T, Leng Y, Li MZ, Xu Q, Elledge SJGenes & developmentA genetic interaction analysis identifies cancer drivers that modify EGFR dependency. Genes Dev. 2017 01 15; 31(2):184-196.Genes Dev2017-01-15T00:00:002017A genetic interaction analysis identifies cancer drivers that modify EGFR dependency.Authorship 669593Authorship 958301628217959Shah AA, Xu G, Rosen A, Hummers LK, Wigley FM, Elledge SJ, Casciola-Rosen LArthritis & rheumatology (Hoboken, N.J.)Brief Report: Anti-RNPC-3 Antibodies As a Marker of Cancer-Associated Scleroderma. Arthritis Rheumatol. 2017 06; 69(6):1306-1312.Arthritis Rheumatol2017-06-01T00:00:002017Brief Report: Anti-RNPC-3 Antibodies As a Marker of Cancer-Associated Scleroderma.8791622Bai C, Elledge SJMethods in enzymologyGene identification using the yeast two-hybrid system. Methods Enzymol. 1996; 273:331-47.Methods Enzymol1996-01-01T00:00:001996Gene identification using the yeast two-hybrid system.8791491Harper JW, Elledge SJCurrent opinion in genetics & developmentCdk inhibitors in development and cancer. Curr Opin Genet Dev. 1996 Feb; 6(1):56-64.Curr Opin Genet Dev1996-02-01T00:00:001996Cdk inhibitors in development and cancer.8895664Navas TA, Sanchez Y, Elledge SJGenes & developmentRAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae. Genes Dev. 1996 Oct 15; 10(20):2632-43.Genes Dev1996-10-15T00:00:001996RAD9 and DNA polymerase epsilon form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae.8824640Siede W, Allen JB, Elledge SJ, Friedberg ECJournal of bacteriologyThe Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment. J Bacteriol. 1996 Oct; 178(19):5841-3.J Bacteriol1996-10-01T00:00:001996The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment.8945475Sicinski P, Donaher JL, Geng Y, Parker SB, Gardner H, Park MY, Robker RL, Richards JS, McGinnis LK, Biggers JD, Eppig JJ, Bronson RT, Elledge SJ, Weinberg RANatureCyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature. 1996 Dec 05; 384(6608):470-4.Nature1996-12-05T00:00:001996Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis.9144284Zhang P, Liégeois NJ, Wong C, Finegold M, Hou H, Thompson JC, Silverman A, Harper JW, DePinho RA, Elledge SJNatureAltered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome. Nature. 1997 May 08; 387(6629):151-8.Nature1997-05-08T00:00:001997Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome.9490488Elledge SJScience (New York, N.Y.)Mitotic arrest: Mad2 prevents sleepy from waking up the APC. Science. 1998 Feb 13; 279(5353):999-1000.Science1998-02-13T00:00:001998Mitotic arrest: Mad2 prevents sleepy from waking up the APC.11100718Zhou BB, Elledge SJNatureThe DNA damage response: putting checkpoints in perspective. Nature. 2000 Nov 23; 408(6811):433-9.Nature2000-11-23T00:00:002000The DNA damage response: putting checkpoints in perspective.12578828Morales JC, Xia Z, Lu T, Aldrich MB, Wang B, Rosales C, Kellems RE, Hittelman WN, Elledge SJ, Carpenter PBThe Journal of biological chemistryRole for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. J Biol Chem. 2003 Apr 25; 278(17):14971-7.J Biol Chem2003-02-10T00:00:002003Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability.12607005Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJNatureMDC1 is a mediator of the mammalian DNA damage checkpoint. Nature. 2003 Feb 27; 421(6926):961-6.Nature2003-02-27T00:00:002003MDC1 is a mediator of the mammalian DNA damage checkpoint.10445024Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter PMolecular cellSGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. Mol Cell. 1999 Jul; 4(1):21-33.Mol Cell1999-07-01T00:00:001999SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex.10550055Cortez D, Wang Y, Qin J, Elledge SJScience (New York, N.Y.)Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science. 1999 Nov 05; 286(5442):1162-6.Science1999-11-05T00:00:001999Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.10601037Caspary T, Cleary MA, Perlman EJ, Zhang P, Elledge SJ, Tilghman SMGenes & developmentOppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome. Genes Dev. 1999 Dec 01; 13(23):3115-24.Genes Dev1999-12-01T00:00:001999Oppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome.10692401Orozco BM, Kong LJ, Batts LA, Elledge S, Hanley-Bowdoin LThe Journal of biological chemistryThe multifunctional character of a geminivirus replication protein is reflected by its complex oligomerization properties. J Biol Chem. 2000 Mar 03; 275(9):6114-22.J Biol Chem2000-03-03T00:00:002000The multifunctional character of a geminivirus replication protein is reflected by its complex oligomerization properties.12760057Huang M, Elledge SJCold Spring Harbor symposia on quantitative biologyThe FHA domain, a phosphoamino acid binding domain involved in the DNA damage response pathway. Cold Spring Harb Symp Quant Biol. 2000; 65:413-21.Cold Spring Harb Symp Quant Biol2000-01-01T00:00:002000The FHA domain, a phosphoamino acid binding domain involved in the DNA damage response pathway.15157521Elledge SJ, Winston J, Harper JWTrends in cell biologyA question of balance: the role of cyclin-kinase inhibitors in development and tumorigenesis. Trends Cell Biol. 1996 Oct; 6(10):388-92.Trends Cell Biol1996-10-01T00:00:001996A question of balance: the role of cyclin-kinase inhibitors in development and tumorigenesis.15520277Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JWGenes & developmentSystematic analysis and nomenclature of mammalian F-box proteins. Genes Dev. 2004 Nov 01; 18(21):2573-80.Genes Dev2004-11-01T00:00:002004Systematic analysis and nomenclature of mammalian F-box proteins.15632076Li JM, Li Y, Elledge SJMolecular and cellular biologyGenetic analysis of the kinetochore DASH complex reveals an antagonistic relationship with the ras/protein kinase A pathway and a novel subunit required for Ask1 association. Mol Cell Biol. 2005 Jan; 25(2):767-78.Mol Cell Biol2005-01-01T00:00:002005Genetic analysis of the kinetochore DASH complex reveals an antagonistic relationship with the ras/protein kinase A pathway and a novel subunit required for Ask1 association.15746409Altman S, Bassler BL, Beckwith J, Belfort M, Berg HC, Bloom B, Brenchley JE, Campbell A, Collier RJ, Connell N, Cozzarelli NR, Craig NL, Darst S, Ebright RH, Elledge SJ, Falkow S, Galan JE, Gottesman M, Gourse R, Grindley ND, Gross CA, Grossman A, Hochschild A, Howe M, Hurwitz J, Isberg RR, Kaplan S, Kornberg A, Kustu SG, Landick RC, Landy A, Levy SB, Losick R, Long SR, Maloy SR, Mekalanos JJ, Neidhardt FC, Pace NR, Ptashne M, Roberts JW, Roth JR, Rothman-Denes LB, Salyers A, Schaechter M, Shapiro L, Silhavy TJ, Simon MI, Walker G, Yanofsky C, Zinder NScience (New York, N.Y.)An open letter to Elias Zerhouni. Science. 2005 Mar 04; 307(5714):1409-10.Science2005-03-04T00:00:002005An open letter to Elias Zerhouni.17116885Chou DM, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaTipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function. Proc Natl Acad Sci U S A. 2006 Nov 28; 103(48):18143-7.Proc Natl Acad Sci U S A2006-11-20T00:00:002006Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function.9843682Liu Q, Li MZ, Leibham D, Cortez D, Elledge SJCurrent biology : CBThe univector plasmid-fusion system, a method for rapid construction of recombinant DNA without restriction enzymes. Curr Biol. 1998 Dec 03; 8(24):1300-9.Curr Biol1998-12-03T00:00:001998The univector plasmid-fusion system, a method for rapid construction of recombinant DNA without restriction enzymes.10559870Harper JW, Elledge SJNature cell biologySkipping into the E2F1-destruction pathway. Nat Cell Biol. 1999 May; 1(1):E5-7.Nat Cell Biol1999-05-01T00:00:001999Skipping into the E2F1-destruction pathway.11533444Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, Elledge SJScience (New York, N.Y.)Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science. 2001 Oct 05; 294(5540):173-7.Science2001-08-30T00:00:002001Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.18851834Lee YD, Wang J, Stubbe J, Elledge SJMolecular cellDif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase. Mol Cell. 2008 Oct 10; 32(1):70-80.Mol Cell2008-10-10T00:00:002008Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase.18931676Ishiai M, Kitao H, Smogorzewska A, Tomida J, Kinomura A, Uchida E, Saberi A, Kinoshita E, Kinoshita-Kikuta E, Koike T, Tashiro S, Elledge SJ, Takata MNature structural & molecular biologyFANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. Nat Struct Mol Biol. 2008 Nov; 15(11):1138-46.Nat Struct Mol Biol2008-10-19T00:00:002008FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway.1714386Elledge SJ, Spottswood MRThe EMBO journalA new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1. EMBO J. 1991 Sep; 10(9):2653-9.EMBO J1991-09-01T00:00:001991A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.1372993Elledge SJ, Richman R, Hall FL, Williams RT, Lodgson N, Harper JWProceedings of the National Academy of Sciences of the United States of AmericaCDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2907-11.Proc Natl Acad Sci U S A1992-04-01T00:00:001992CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle.1412696Elledge SJ, Zhou Z, Allen JBTrends in biochemical sciencesRibonucleotide reductase: regulation, regulation, regulation. Trends Biochem Sci. 1992 Mar; 17(3):119-23.Trends Biochem Sci1992-03-01T00:00:001992Ribonucleotide reductase: regulation, regulation, regulation.9836640Matsuoka S, Huang M, Elledge SJScience (New York, N.Y.)Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science. 1998 Dec 04; 282(5395):1893-7.Science1998-12-04T00:00:001998Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.10716425Lozano G, Elledge SJNaturep53 sends nucleotides to repair DNA. Nature. 2000 Mar 02; 404(6773):24-5.Nature2000-03-02T00:00:002000p53 sends nucleotides to repair DNA.10783165Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin JGenes & developmentBASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 2000 Apr 15; 14(8):927-39.Genes Dev2000-04-15T00:00:002000BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.11132426Goldberg AL, Elledge SJ, Harper JWScientific AmericanThe cellular chamber of doom. Sci Am. 2001 Jan; 284(1):68-73.Sci Am2001-01-01T00:00:002001The cellular chamber of doom.11331602Hu F, Alcasabas AA, Elledge SJGenes & developmentAsf1 links Rad53 to control of chromatin assembly. Genes Dev. 2001 May 01; 15(9):1061-6.Genes Dev2001-05-01T00:00:002001Asf1 links Rad53 to control of chromatin assembly.1618142Bellen HJ, D'Evelyn D, Harvey M, Elledge SJDevelopment (Cambridge, England)Isolation of temperature-sensitive diphtheria toxins in yeast and their effects on Drosophila cells. Development. 1992 Mar; 114(3):787-96.Development1992-03-01T00:00:001992Isolation of temperature-sensitive diphtheria toxins in yeast and their effects on Drosophila cells.12364621Wang B, Matsuoka S, Carpenter PB, Elledge SJScience (New York, N.Y.)53BP1, a mediator of the DNA damage checkpoint. Science. 2002 Nov 15; 298(5597):1435-8.Science2002-10-03T00:00:00200253BP1, a mediator of the DNA damage checkpoint.17525340Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJScience (New York, N.Y.)Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science. 2007 May 25; 316(5828):1194-8.Science2007-05-25T00:00:002007Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.9784491Zhang P, Wong C, DePinho RA, Harper JW, Elledge SJGenes & developmentCooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development. Genes Dev. 1998 Oct 15; 12(20):3162-7.Genes Dev1998-10-15T00:00:001998Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development.10973490Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaAtaxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci U S A. 2000 Sep 12; 97(19):10389-94.Proc Natl Acad Sci U S A2000-09-12T00:00:002000Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.14681206Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, Harper JWGenes & developmentSCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev. 2003 Dec 15; 17(24):3062-74.Genes Dev2003-12-15T00:00:002003SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.11715016Alcasabas AA, Osborn AJ, Bachant J, Hu F, Werler PJ, Bousset K, Furuya K, Diffley JF, Carr AM, Elledge SJNature cell biologyMrc1 transduces signals of DNA replication stress to activate Rad53. Nat Cell Biol. 2001 Nov; 3(11):958-65.Nat Cell Biol2001-11-01T00:00:002001Mrc1 transduces signals of DNA replication stress to activate Rad53.9744871Desany BA, Alcasabas AA, Bachant JB, Elledge SJGenes & developmentRecovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway. Genes Dev. 1998 Sep 15; 12(18):2956-70.Genes Dev1998-09-15T00:00:001998Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway.11454675Matsuoka S, Nakagawa T, Masuda A, Haruki N, Elledge SJ, Takahashi TCancer researchReduced expression and impaired kinase activity of a Chk2 mutant identified in human lung cancer. Cancer Res. 2001 Jul 15; 61(14):5362-5.Cancer Res2001-07-15T00:00:002001Reduced expression and impaired kinase activity of a Chk2 mutant identified in human lung cancer.22388088Aceto N, Sausgruber N, Brinkhaus H, Gaidatzis D, Martiny-Baron G, Mazzarol G, Confalonieri S, Quarto M, Hu G, Balwierz PJ, Pachkov M, Elledge SJ, van Nimwegen E, Stadler MB, Bentires-Alj MNature medicineTyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop. Nat Med. 2012 Mar 04; 18(4):529-37.Nat Med2012-03-04T00:00:002012Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop.17558397Popov N, Wanzel M, Madiredjo M, Zhang D, Beijersbergen R, Bernards R, Moll R, Elledge SJ, Eilers MNature cell biologyThe ubiquitin-specific protease USP28 is required for MYC stability. Nat Cell Biol. 2007 Jul; 9(7):765-74.Nat Cell Biol2007-06-10T00:00:002007The ubiquitin-specific protease USP28 is required for MYC stability.8939848Elledge SJScience (New York, N.Y.)Cell cycle checkpoints: preventing an identity crisis. Science. 1996 Dec 06; 274(5293):1664-72.Science1996-12-06T00:00:001996Cell cycle checkpoints: preventing an identity crisis.10338207Koepp DM, Harper JW, Elledge SJCellHow the cyclin became a cyclin: regulated proteolysis in the cell cycle. Cell. 1999 May 14; 97(4):431-4.Cell1999-05-14T00:00:001999How the cyclin became a cyclin: regulated proteolysis in the cell cycle.11353843Paull TT, Cortez D, Bowers B, Elledge SJ, Gellert MProceedings of the National Academy of Sciences of the United States of AmericaDirect DNA binding by Brca1. Proc Natl Acad Sci U S A. 2001 May 22; 98(11):6086-91.Proc Natl Acad Sci U S A2001-05-15T00:00:002001Direct DNA binding by Brca1.15261141Lam MH, Liu Q, Elledge SJ, Rosen JMCancer cellChk1 is haploinsufficient for multiple functions critical to tumor suppression. Cancer Cell. 2004 Jul; 6(1):45-59.Cancer Cell2004-07-01T00:00:002004Chk1 is haploinsufficient for multiple functions critical to tumor suppression.16885023Wang X, Zou L, Lu T, Bao S, Hurov KE, Hittelman WN, Elledge SJ, Li LMolecular cellRad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress. Mol Cell. 2006 Aug 04; 23(3):331-41.Mol Cell2006-08-04T00:00:002006Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress.9383053Edwards MC, Liegeois N, Horecka J, DePinho RA, Sprague GF, Tyers M, Elledge SJGeneticsHuman CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells. Genetics. 1997 Nov; 147(3):1063-76.Genetics1997-11-01T00:00:001997Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells.11099048Schulman BA, Carrano AC, Jeffrey PD, Bowen Z, Kinnucan ER, Finnin MS, Elledge SJ, Harper JW, Pagano M, Pavletich NPNatureInsights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Nature. 2000 Nov 16; 408(6810):381-6.Nature2000-11-16T00:00:002000Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.11753384Zhang P, Li MZ, Elledge SJNature geneticsTowards genetic genome projects: genomic library screening and gene-targeting vector construction in a single step. Nat Genet. 2002 Jan; 30(1):31-9.Nat Genet2001-12-20T00:00:002001Towards genetic genome projects: genomic library screening and gene-targeting vector construction in a single step.12628189Wang Y, Shirogane T, Liu D, Harper JW, Elledge SJCellExit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling. Cell. 2003 Mar 07; 112(5):697-709.Cell2003-03-07T00:00:002003Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling.12865299Osborn AJ, Elledge SJGenes & developmentMrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53. Genes Dev. 2003 Jul 15; 17(14):1755-67.Genes Dev2003-07-15T00:00:002003Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.10710310Hirao A, Kong YY, Matsuoka S, Wakeham A, Ruland J, Yoshida H, Liu D, Elledge SJ, Mak TWScience (New York, N.Y.)DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science. 2000 Mar 10; 287(5459):1824-7.Science2000-03-10T00:00:002000DNA damage-induced activation of p53 by the checkpoint kinase Chk2.18690214Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, Xavier RJ, Agaisse H, Fikrig ENatureRNA interference screen for human genes associated with West Nile virus infection. Nature. 2008 Sep 11; 455(7210):242-5.Nature2008-09-11T00:00:002008RNA interference screen for human genes associated with West Nile virus infection.12086871Elledge SJ, Amon ACancer cellThe BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients. Cancer Cell. 2002 Mar; 1(2):129-32.Cancer Cell2002-03-01T00:00:002002The BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients.21628590Emanuele MJ, Ciccia A, Elia AE, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaProliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate. Proc Natl Acad Sci U S A. 2011 Jun 14; 108(24):9845-50.Proc Natl Acad Sci U S A2011-05-31T00:00:002011Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate.21764741Joo W, Xu G, Persky NS, Smogorzewska A, Rudge DG, Buzovetsky O, Elledge SJ, Pavletich NPScience (New York, N.Y.)Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway. Science. 2011 Jul 15; 333(6040):312-6.Science2011-07-15T00:00:002011Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway.14605214Zou L, Liu D, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaReplication protein A-mediated recruitment and activation of Rad17 complexes. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):13827-32.Proc Natl Acad Sci U S A2003-11-06T00:00:002003Replication protein A-mediated recruitment and activation of Rad17 complexes.15210935Cortez D, Glick G, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaMinichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases. Proc Natl Acad Sci U S A. 2004 Jul 06; 101(27):10078-83.Proc Natl Acad Sci U S A2004-06-21T00:00:002004Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.12672690Wang X, Zou L, Zheng H, Wei Q, Elledge SJ, Li LGenes & developmentGenomic instability and endoreduplication triggered by RAD17 deletion. Genes Dev. 2003 Apr 15; 17(8):965-70.Genes Dev2003-04-02T00:00:002003Genomic instability and endoreduplication triggered by RAD17 deletion.14528307Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ, Mills AA, Elledge SJ, Anderson KV, Hannon GJNature geneticsDicer is essential for mouse development. Nat Genet. 2003 Nov; 35(3):215-7.Nat Genet2003-10-05T00:00:002003Dicer is essential for mouse development.16452505Lee YD, Elledge SJGenes & developmentControl of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1. Genes Dev. 2006 Feb 01; 20(3):334-44.Genes Dev2006-02-01T00:00:002006Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1.9077451Lin R, Allis CD, Elledge SJGenes to cells : devoted to molecular & cellular mechanismsPAT1, an evolutionarily conserved acetyltransferase homologue, is required for multiple steps in the cell cycle. Genes Cells. 1996 Oct; 1(10):923-42.Genes Cells1996-10-01T00:00:001996PAT1, an evolutionarily conserved acetyltransferase homologue, is required for multiple steps in the cell cycle.18082599Harper JW, Elledge SJMolecular cellThe DNA damage response: ten years after. Mol Cell. 2007 Dec 14; 28(5):739-45.Mol Cell2007-12-14T00:00:002007The DNA damage response: ten years after.10213692Skowyra D, Koepp DM, Kamura T, Conrad MN, Conaway RC, Conaway JW, Elledge SJ, Harper JWScience (New York, N.Y.)Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1. Science. 1999 Apr 23; 284(5414):662-5.Science1999-04-23T00:00:001999Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.15364936Ye X, Nalepa G, Welcker M, Kessler BM, Spooner E, Qin J, Elledge SJ, Clurman BE, Harper JWThe Journal of biological chemistryRecognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase. J Biol Chem. 2004 Nov 26; 279(48):50110-9.J Biol Chem2004-09-13T00:00:002004Recognition of phosphodegron motifs in human cyclin E by the SCF(Fbw7) ubiquitin ligase.11075365Liu Q, Li MZ, Liu D, Elledge SJMethods in enzymologyRapid construction of recombinant DNA by the univector plasmid-fusion system. Methods Enzymol. 2000; 328:530-49.Methods Enzymol2000-01-01T00:00:002000Rapid construction of recombinant DNA by the univector plasmid-fusion system.19748364Shen X, Do H, Li Y, Chung WH, Tomasz M, de Winter JP, Xia B, Elledge SJ, Wang W, Li LMolecular cellRecruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication. Mol Cell. 2009 Sep 11; 35(5):716-23.Mol Cell2009-09-11T00:00:002009Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication.Authorship 9951146Authorship 99679811Authorship 997627628454209Shah AA, Rosen A, Hummers LK, Wigley FM, Xu G, Elledge SJ, Casciola-Rosen LArthritis & rheumatology (Hoboken, N.J.)Reply. Arthritis Rheumatol. 2017 09; 69(9):1915-1916.Arthritis Rheumatol2017-07-11T00:00:002017Reply.28700943Martin TD, Cook DR, Choi MY, Li MZ, Haigis KM, Elledge SJCell reportsA Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Cell Rep. 2017 07 11; 20(2):427-438.Cell Rep2017-07-11T00:00:002017A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.28684519Naxerova K, Reiter JG, Brachtel E, Lennerz JK, van de Wetering M, Rowan A, Cai T, Clevers H, Swanton C, Nowak MA, Elledge SJ, Jain RKScience (New York, N.Y.)Origins of lymphatic and distant metastases in human colorectal cancer. Science. 2017 Jul 07; 357(6346):55-60.Science2017-07-07T00:00:002017Origins of lymphatic and distant metastases in human colorectal cancer.8706131Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, Elledge SJCellSKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell. 1996 Jul 26; 86(2):263-74.Cell1996-07-26T00:00:001996SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.17417629Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK, Harper JW, Elledge SJNature cell biologyA functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nat Cell Biol. 2007 May; 9(5):556-64.Nat Cell Biol2007-04-08T00:00:002007A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.18995830Collis SJ, Ciccia A, Deans AJ, Horejsí Z, Martin JS, Maslen SL, Skehel JM, Elledge SJ, West SC, Boulton SJMolecular cellFANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol Cell. 2008 Nov 07; 32(3):313-24.Mol Cell2008-11-07T00:00:002008FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex.19339689Hu G, Kim J, Xu Q, Leng Y, Orkin SH, Elledge SJGenes & developmentA genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes Dev. 2009 Apr 01; 23(7):837-48.Genes Dev2009-04-01T00:00:002009A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal.2513480Elledge SJ, Davis RWMolecular and cellular biologyDNA damage induction of ribonucleotide reductase. Mol Cell Biol. 1989 Nov; 9(11):4932-40.Mol Cell Biol1989-11-01T00:00:001989DNA damage induction of ribonucleotide reductase.20133776Schlabach MR, Hu JK, Li M, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaSynthetic design of strong promoters. Proc Natl Acad Sci U S A. 2010 Feb 09; 107(6):2538-43.Proc Natl Acad Sci U S A2010-01-21T00:00:002010Synthetic design of strong promoters.9450924Harper JW, Elledge SJGenes & developmentThe role of Cdk7 in CAK function, a retro-retrospective. Genes Dev. 1998 Feb 01; 12(3):285-9.Genes Dev1998-02-01T00:00:001998The role of Cdk7 in CAK function, a retro-retrospective.22344029Adamson B, Smogorzewska A, Sigoillot FD, King RW, Elledge SJNature cell biologyA genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nat Cell Biol. 2012 Feb 19; 14(3):318-28.Nat Cell Biol2012-02-19T00:00:002012A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response.1388288Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JMScience (New York, N.Y.)Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science. 1992 Sep 18; 257(5077):1689-94.Science1992-09-18T00:00:001992Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle.18077395Wang B, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaUbc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc Natl Acad Sci U S A. 2007 Dec 26; 104(52):20759-63.Proc Natl Acad Sci U S A2007-12-05T00:00:002007Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage.18187620Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJScience (New York, N.Y.)Identification of host proteins required for HIV infection through a functional genomic screen. Science. 2008 Feb 15; 319(5865):921-6.Science2008-01-10T00:00:002008Identification of host proteins required for HIV infection through a functional genomic screen.19109439Zhang L, Lee SY, Beznoussenko GV, Peters PJ, Yang JS, Gilbert HY, Brass AL, Elledge SJ, Isaacs SN, Moss B, Mironov A, Hsu VWProceedings of the National Academy of Sciences of the United States of AmericaA role for the host coatomer and KDEL receptor in early vaccinia biogenesis. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):163-8.Proc Natl Acad Sci U S A2008-12-24T00:00:002008A role for the host coatomer and KDEL receptor in early vaccinia biogenesis.19717417Li Q, Brass AL, Ng A, Hu Z, Xavier RJ, Liang TJ, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaA genome-wide genetic screen for host factors required for hepatitis C virus propagation. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16410-5.Proc Natl Acad Sci U S A2009-08-27T00:00:002009A genome-wide genetic screen for host factors required for hepatitis C virus propagation.21963094Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJCellGlobal identification of modular cullin-RING ligase substrates. Cell. 2011 Oct 14; 147(2):459-74.Cell2011-09-29T00:00:002011Global identification of modular cullin-RING ligase substrates.22328425Li MZ, Elledge SJMethods in molecular biology (Clifton, N.J.)SLIC: a method for sequence- and ligation-independent cloning. Methods Mol Biol. 2012; 852:51-9.Methods Mol Biol2012-01-01T00:00:002012SLIC: a method for sequence- and ligation-independent cloning.20595234Song EJ, Werner SL, Neubauer J, Stegmeier F, Aspden J, Rio D, Harper JW, Elledge SJ, Kirschner MW, Rape MGenes & developmentThe Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. Genes Dev. 2010 Jul 01; 24(13):1434-47.Genes Dev2010-07-01T00:00:002010The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome.20660729Burrows AE, Smogorzewska A, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaPolybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14280-5.Proc Natl Acad Sci U S A2010-07-26T00:00:002010Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence.Authorship 1001408228800914Watson EV, Elledge SJTrends in genetics : TIGAneuploidy Police Detect Chromosomal Imbalance Triggering Immune Crackdown! Trends Genet. 2017 10; 33(10):662-664.Trends Genet2017-08-08T00:00:002017Aneuploidy Police Detect Chromosomal Imbalance Triggering Immune Crackdown!19596235Svendsen JM, Smogorzewska A, Sowa ME, O'Connell BC, Gygi SP, Elledge SJ, Harper JWCellMammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell. 2009 Jul 10; 138(1):63-77.Cell2009-07-10T00:00:002009Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.7544399Tian Q, Taupin J, Elledge S, Robertson M, Anderson PThe Journal of experimental medicineFas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. J Exp Med. 1995 Sep 01; 182(3):865-74.J Exp Med1995-09-01T00:00:001995Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.7958905Allen JB, Zhou Z, Siede W, Friedberg EC, Elledge SJGenes & developmentThe SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev. 1994 Oct 15; 8(20):2401-15.Genes Dev1994-10-15T00:00:001994The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast.8383120Staudinger J, Perry M, Elledge SJ, Olson ENThe Journal of biological chemistryInteractions among vertebrate helix-loop-helix proteins in yeast using the two-hybrid system. J Biol Chem. 1993 Mar 05; 268(7):4608-11.J Biol Chem1993-03-05T00:00:001993Interactions among vertebrate helix-loop-helix proteins in yeast using the two-hybrid system.9990852Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JWGenes & developmentThe SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. Genes Dev. 1999 Feb 01; 13(3):270-83.Genes Dev1999-02-01T00:00:001999The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.10550056Sanchez Y, Bachant J, Wang H, Hu F, Liu D, Tetzlaff M, Elledge SJScience (New York, N.Y.)Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. Science. 1999 Nov 05; 286(5442):1166-71.Science1999-11-05T00:00:001999Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.15096610Lin SY, Li K, Stewart GS, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaHuman Claspin works with BRCA1 to both positively and negatively regulate cell proliferation. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17):6484-9.Proc Natl Acad Sci U S A2004-04-19T00:00:002004Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation.19965384Knipscheer P, Räschle M, Smogorzewska A, Enoiu M, Ho TV, Schärer OD, Elledge SJ, Walter JCScience (New York, N.Y.)The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science. 2009 Dec 18; 326(5960):1698-701.Science2009-11-12T00:00:002009The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.9154808Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin MMolecular and cellular biologyIsolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. Mol Cell Biol. 1997 Jun; 17(6):3094-102.Mol Cell Biol1997-06-01T00:00:001997Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions.9427630Connell-Crowley L, Elledge SJ, Harper JWCurrent biology : CBG1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts. Curr Biol. 1998 Jan 01; 8(1):65-8.Curr Biol1998-01-01T00:00:001998G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts.7575496Sanchez Y, Elledge SJBioEssays : news and reviews in molecular, cellular and developmental biologyStopped for repairs. Bioessays. 1995 Jun; 17(6):545-8.Bioessays1995-06-01T00:00:001995Stopped for repairs.8137420Dulic V, Kaufmann WK, Wilson SJ, Tlsty TD, Lees E, Harper JW, Elledge SJ, Reed SICellp53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell. 1994 Mar 25; 76(6):1013-23.Cell1994-03-25T00:00:001994p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.11598186Gasch AP, Huang M, Metzner S, Botstein D, Elledge SJ, Brown POMolecular biology of the cellGenomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. Mol Biol Cell. 2001 Oct; 12(10):2987-3003.Mol Biol Cell2001-10-01T00:00:002001Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p.11721054Cortez D, Guntuku S, Qin J, Elledge SJScience (New York, N.Y.)ATR and ATRIP: partners in checkpoint signaling. Science. 2001 Nov 23; 294(5547):1713-6.Science2001-11-23T00:00:002001ATR and ATRIP: partners in checkpoint signaling.12461298Hu F, Elledge SJCell cycle (Georgetown, Tex.)Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints. Cell Cycle. 2002 Sep-Oct; 1(5):351-5.Cell Cycle2002-09-01T00:00:002002Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints.14993286Tetzlaff MT, Bai C, Finegold M, Wilson J, Harper JW, Mahon KA, Elledge SJMolecular and cellular biologyCyclin F disruption compromises placental development and affects normal cell cycle execution. Mol Cell Biol. 2004 Mar; 24(6):2487-98.Mol Cell Biol2004-03-01T00:00:002004Cyclin F disruption compromises placental development and affects normal cell cycle execution.16675955Cao L, Kim S, Xiao C, Wang RH, Coumoul X, Wang X, Li WM, Xu XL, De Soto JA, Takai H, Mai S, Elledge SJ, Motoyama N, Deng CXThe EMBO journalATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. EMBO J. 2006 May 17; 25(10):2167-77.EMBO J2006-05-04T00:00:002006ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency.2199320Elledge SJ, Davis RWGenes & developmentTwo genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase. Genes Dev. 1990 May; 4(5):740-51.Genes Dev1990-05-01T00:00:001990Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase.11799063Zou L, Cortez D, Elledge SJGenes & developmentRegulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev. 2002 Jan 15; 16(2):198-208.Genes Dev2002-01-15T00:00:002002Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin.12150898Stewart G, Elledge SJMolecular cellThe two faces of BRCA2, a FANCtastic discovery. Mol Cell. 2002 Jul; 10(1):2-4.Mol Cell2002-07-01T00:00:002002The two faces of BRCA2, a FANCtastic discovery.12228708Wilson JH, Elledge SJScience (New York, N.Y.)Cancer. BRCA2 enters the fray. Science. 2002 Sep 13; 297(5588):1822-3.Science2002-09-13T00:00:002002Cancer. BRCA2 enters the fray.16141338Stegmeier F, Hu G, Rickles RJ, Hannon GJ, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaA lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc Natl Acad Sci U S A. 2005 Sep 13; 102(37):13212-7.Proc Natl Acad Sci U S A2005-09-01T00:00:002005A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells.17525332Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJScience (New York, N.Y.)ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25; 316(5828):1160-6.Science2007-05-25T00:00:002007ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.18563141Luo J, Elledge SJNatureCancer: Deconstructing oncogenesis. Nature. 2008 Jun 19; 453(7198):995-6.Nature2008-06-19T00:00:002008Cancer: Deconstructing oncogenesis.20965415Ciccia A, Elledge SJMolecular cellThe DNA damage response: making it safe to play with knives. Mol Cell. 2010 Oct 22; 40(2):179-204.Mol Cell2010-10-22T00:00:002010The DNA damage response: making it safe to play with knives.Authorship 1023253829089421Mazzucco AE, Smogorzewska A, Kang C, Luo J, Schlabach MR, Xu Q, Patel R, Elledge SJGenes & developmentGenetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. Genes Dev. 2017 10 01; 31(19):1933-1938.Genes Dev2017-10-01T00:00:002017Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program.9251037Sanchez Y, Zhou Z, Huang M, Kemp BE, Elledge SJMethods in enzymologyAnalysis of budding yeast kinases controlled by DNA damage. Methods Enzymol. 1997; 283:398-410.Methods Enzymol1997-01-01T00:00:001997Analysis of budding yeast kinases controlled by DNA damage.16294047Adams MM, Wang B, Xia Z, Morales JC, Lu X, Donehower LA, Bochar DA, Elledge SJ, Carpenter PBCell cycle (Georgetown, Tex.)53BP1 oligomerization is independent of its methylation by PRMT1. Cell Cycle. 2005 Dec; 4(12):1854-61.Cell Cycle2005-12-28T00:00:00200553BP1 oligomerization is independent of its methylation by PRMT1.11084339Wang Y, Hu F, Elledge SJCurrent biology : CBThe Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit. Curr Biol. 2000 Nov 02; 10(21):1379-82.Curr Biol2000-11-02T00:00:002000The Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit.12192050Hirao A, Cheung A, Duncan G, Girard PM, Elia AJ, Wakeham A, Okada H, Sarkissian T, Wong JA, Sakai T, De Stanchina E, Bristow RG, Suda T, Lowe SW, Jeggo PA, Elledge SJ, Mak TWMolecular and cellular biologyChk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol. 2002 Sep; 22(18):6521-32.Mol Cell Biol2002-09-01T00:00:002002Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.12446112Osborn AJ, Elledge SJ, Zou LTrends in cell biologyChecking on the fork: the DNA-replication stress-response pathway. Trends Cell Biol. 2002 Nov; 12(11):509-16.Trends Cell Biol2002-11-01T00:00:002002Checking on the fork: the DNA-replication stress-response pathway.12695666Li Y, Elledge SJCell cycle (Georgetown, Tex.)The DASH complex component Ask1 is a cell cycle-regulated Cdk substrate in Saccharomyces cerevisiae. Cell Cycle. 2003 Mar-Apr; 2(2):143-8.Cell Cycle2003-03-01T00:00:002003The DASH complex component Ask1 is a cell cycle-regulated Cdk substrate in Saccharomyces cerevisiae.14562514Zou L, Elledge SJHarvey lecturesSensing and signaling DNA damage: roles of Rad17 and Rad9 complexes in the cellular response to DNA damage. Harvey Lect. 2001-2002; 97:1-15.Harvey Lect2001-01-01T00:00:002001Sensing and signaling DNA damage: roles of Rad17 and Rad9 complexes in the cellular response to DNA damage.21602805Larman HB, Zhao Z, Laserson U, Li MZ, Ciccia A, Gakidis MA, Church GM, Kesari S, Leproust EM, Solimini NL, Elledge SJNature biotechnologyAutoantigen discovery with a synthetic human peptidome. Nat Biotechnol. 2011 May 22; 29(6):535-41.Nat Biotechnol2011-05-22T00:00:002011Autoantigen discovery with a synthetic human peptidome.16869781Westbrook TF, Stegmeier F, Elledge SJCold Spring Harbor symposia on quantitative biologyDissecting cancer pathways and vulnerabilities with RNAi. Cold Spring Harb Symp Quant Biol. 2005; 70:435-44.Cold Spring Harb Symp Quant Biol2005-01-01T00:00:002005Dissecting cancer pathways and vulnerabilities with RNAi.16929316Chang K, Elledge SJ, Hannon GJNature methodsLessons from Nature: microRNA-based shRNA libraries. Nat Methods. 2006 Sep; 3(9):707-14.Nat Methods2006-09-01T00:00:002006Lessons from Nature: microRNA-based shRNA libraries.6291635Walker GC, Elledge SJ, Kenyon CJ, Krueger JH, Perry KLBiochimieMutagenesis and other responses induced by DNA damage in Escherichia coli. Biochimie. 1982 Aug-Sep; 64(8-9):607-10.Biochimie1982-08-01T00:00:001982Mutagenesis and other responses induced by DNA damage in Escherichia coli.7813445Bai C, Richman R, Elledge SJThe EMBO journalHuman cyclin F. EMBO J. 1994 Dec 15; 13(24):6087-98.EMBO J1994-12-15T00:00:001994Human cyclin F.7863329Parker SB, Eichele G, Zhang P, Rawls A, Sands AT, Bradley A, Olson EN, Harper JW, Elledge SJScience (New York, N.Y.)p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science. 1995 Feb 17; 267(5200):1024-7.Science1995-02-17T00:00:001995p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells.7900415Allen JB, Elledge SJYeast (Chichester, England)A family of vectors that facilitate transposon and insertional mutagenesis of cloned genes in yeast. Yeast. 1994 Oct; 10(10):1267-72.Yeast1994-10-01T00:00:001994A family of vectors that facilitate transposon and insertional mutagenesis of cloned genes in yeast.29249356Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, Hochedlinger KCellNudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling. Cell. 2018 01 11; 172(1-2):106-120.e21.Cell2017-12-14T00:00:002017Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling.8119416Helps NR, Street AJ, Elledge SJ, Cohen PTFEBS lettersCloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli. FEBS Lett. 1994 Feb 28; 340(1-2):93-8.FEBS Lett1994-02-28T00:00:001994Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli.8384581Durfee T, Becherer K, Chen PL, Yeh SH, Yang Y, Kilburn AE, Lee WH, Elledge SJGenes & developmentThe retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 1993 Apr; 7(4):555-69.Genes Dev1993-04-01T00:00:001993The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.17412408Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald ER, Hurov KE, Luo J, Ballif BA, Gygi SP, Hofmann K, D'Andrea AD, Elledge SJCellIdentification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell. 2007 Apr 20; 129(2):289-301.Cell2007-04-05T00:00:002007Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.Authorship 1034059102657725Elledge SJ, Sugiono P, Guarente L, Davis RWProceedings of the National Academy of Sciences of the United States of AmericaGenetic selection for genes encoding sequence-specific DNA-binding proteins. Proc Natl Acad Sci U S A. 1989 May; 86(10):3689-93.Proc Natl Acad Sci U S A1989-05-01T00:00:001989Genetic selection for genes encoding sequence-specific DNA-binding proteins.22157079Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, Bernardi RJ, Yu B, Hsu T, Golding I, Luo J, Osborne CK, Creighton CJ, Hilsenbeck SG, Schiff R, Shaw CA, Elledge SJ, Westbrook TFScience (New York, N.Y.)A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science. 2012 Jan 20; 335(6066):348-53.Science2011-12-08T00:00:002011A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis.18239126Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, Hannon GJ, Elledge SJScience (New York, N.Y.)Cancer proliferation gene discovery through functional genomics. Science. 2008 Feb 01; 319(5863):620-4.Science2008-02-01T00:00:002008Cancer proliferation gene discovery through functional genomics.Authorship 1035347829284711Mazzucco AE, Smogorzewska A, Kang C, Luo J, Schlabach MR, Xu Q, Patel R, Elledge SJGenes & developmentCorrigendum: Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. Genes Dev. 2017 11 15; 31(22):2310.Genes Dev2017-11-15T00:00:002017Corrigendum: Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program.23041316Zhu J, Gaiha GD, John SP, Pertel T, Chin CR, Gao G, Qu H, Walker BD, Elledge SJ, Brass ALCell reportsReactivation of latent HIV-1 by inhibition of BRD4. Cell Rep. 2012 Oct 25; 2(4):807-16.Cell Rep2012-10-04T00:00:002012Reactivation of latent HIV-1 by inhibition of BRD4.23064238Tan X, Hu L, Luquette LJ, Gao G, Liu Y, Qu H, Xi R, Lu ZJ, Park PJ, Elledge SJNature biotechnologySystematic identification of synergistic drug pairs targeting HIV. Nat Biotechnol. 2012 Nov; 30(11):1125-30.Nat Biotechnol2012-10-14T00:00:002012Systematic identification of synergistic drug pairs targeting HIV.6298183Krueger JH, Elledge SJ, Walker GCJournal of bacteriologyIsolation and characterization of Tn5 insertion mutations in the lexA gene of Escherichia coli. J Bacteriol. 1983 Mar; 153(3):1368-78.J Bacteriol1983-03-01T00:00:001983Isolation and characterization of Tn5 insertion mutations in the lexA gene of Escherichia coli.7772254Inouye C, Remondelli P, Karin M, Elledge SDNA and cell biologyIsolation of a cDNA encoding a metal response element binding protein using a novel expression cloning procedure: the one hybrid system. DNA Cell Biol. 1994 Jul; 13(7):731-42.DNA Cell Biol1994-07-01T00:00:001994Isolation of a cDNA encoding a metal response element binding protein using a novel expression cloning procedure: the one hybrid system.7813016Navas TA, Zhou Z, Elledge SJCellDNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint. Cell. 1995 Jan 13; 80(1):29-39.Cell1995-01-13T00:00:001995DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint.7844141Staudinger J, Zhou J, Burgess R, Elledge SJ, Olson ENThe Journal of cell biologyPICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system. J Cell Biol. 1995 Feb; 128(3):263-71.J Cell Biol1995-02-01T00:00:001995PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system.8571453Allen JB, Walberg MW, Edwards MC, Elledge SJTrends in biochemical sciencesFinding prospective partners in the library: the two-hybrid system and phage display find a match. Trends Biochem Sci. 1995 Dec; 20(12):511-6.Trends Biochem Sci1995-12-01T00:00:001995Finding prospective partners in the library: the two-hybrid system and phage display find a match.8649840Kondo M, Matsuoka S, Uchida K, Osada H, Nagatake M, Takagi K, Harper JW, Takahashi T, Elledge SJ, Takahashi TOncogeneSelective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5. Oncogene. 1996 Mar 21; 12(6):1365-8.Oncogene1996-03-21T00:00:001996Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5.19793862Ciccia A, Bredemeyer AL, Sowa ME, Terret ME, Jallepalli PV, Harper JW, Elledge SJGenes & developmentThe SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart. Genes Dev. 2009 Oct 15; 23(20):2415-25.Genes Dev2009-09-30T00:00:002009The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart.21055985O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper JWMolecular cellA genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol Cell. 2010 Nov 24; 40(4):645-57.Mol Cell2010-11-04T00:00:002010A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.77 Avenue Louis PasteurHarvard Medical SchoolDepartment of Genetics, Rm 158D NRB77 Avenue Louis PasteurBoston02115MA7915843Flores-Rozas H, Kelman Z, Dean FB, Pan ZQ, Harper JW, Elledge SJ, O'Donnell M, Hurwitz JProceedings of the National Academy of Sciences of the United States of AmericaCdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme. Proc Natl Acad Sci U S A. 1994 Aug 30; 91(18):8655-9.Proc Natl Acad Sci U S A1994-08-30T00:00:001994Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme.8481900Leach FS, Elledge SJ, Sherr CJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein BCancer researchAmplification of cyclin genes in colorectal carcinomas. Cancer Res. 1993 May 01; 53(9):1986-9.Cancer Res1993-05-01T00:00:001993Amplification of cyclin genes in colorectal carcinomas.18988848Yen HC, Elledge SJScience (New York, N.Y.)Identification of SCF ubiquitin ligase substrates by global protein stability profiling. Science. 2008 Nov 07; 322(5903):923-9.Science2008-11-07T00:00:002008Identification of SCF ubiquitin ligase substrates by global protein stability profiling.20360724Swedlow JR, Cotta-Ramusino C, Elledge SJNatureCell biology forum: Genome-wide view of mitosis. Nature. 2010 Apr 01; 464(7289):684-5.Nature2010-04-01T00:00:002010Cell biology forum: Genome-wide view of mitosis.23319639Solimini NL, Liang AC, Xu C, Pavlova NN, Xu Q, Davoli T, Li MZ, Wong KK, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaSTOP gene Phactr4 is a tumor suppressor. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):E407-14.Proc Natl Acad Sci U S A2013-01-14T00:00:002013STOP gene Phactr4 is a tumor suppressor.9251017Bai C, Elledge SJMethods in enzymologyGene identification using the yeast two-hybrid system. Methods Enzymol. 1997; 283:141-56.Methods Enzymol1997-01-01T00:00:001997Gene identification using the yeast two-hybrid system.Authorship 10500899278511Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, Elledge SJScience (New York, N.Y.)Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science. 1997 Sep 05; 277(5331):1497-501.Science1997-09-05T00:00:001997Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.10859164Liu Q, Guntuku S, Cui XS, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, Donehower LA, Elledge SJGenes & developmentChk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev. 2000 Jun 15; 14(12):1448-59.Genes Dev2000-06-15T00:00:002000Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.11114888Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, Abraham RTGenes & developmentFunctional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. 2000 Dec 01; 14(23):2989-3002.Genes Dev2000-12-01T00:00:002000Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.11390356Wang H, Liu D, Wang Y, Qin J, Elledge SJGenes & developmentPds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function. Genes Dev. 2001 Jun 01; 15(11):1361-72.Genes Dev2001-06-01T00:00:002001Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function.Authorship 10096921848010Elledge SJ, Mulligan JT, Ramer SW, Spottswood M, Davis RWProceedings of the National Academy of Sciences of the United States of AmericaLambda YES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations. Proc Natl Acad Sci U S A. 1991 Mar 01; 88(5):1731-5.Proc Natl Acad Sci U S A1991-03-01T00:00:001991Lambda YES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations.9311734Lee MP, DeBaun M, Randhawa G, Reichard BA, Elledge SJ, Feinberg APAmerican journal of human geneticsLow frequency of p57KIP2 mutation in Beckwith-Wiedemann syndrome. Am J Hum Genet. 1997 Aug; 61(2):304-9.Am J Hum Genet1997-08-01T00:00:001997Low frequency of p57KIP2 mutation in Beckwith-Wiedemann syndrome.16200065Silva JM, Li MZ, Chang K, Ge W, Golding MC, Rickles RJ, Siolas D, Hu G, Paddison PJ, Schlabach MR, Sheth N, Bradshaw J, Burchard J, Kulkarni A, Cavet G, Sachidanandam R, McCombie WR, Cleary MA, Elledge SJ, Hannon GJNature geneticsSecond-generation shRNA libraries covering the mouse and human genomes. Nat Genet. 2005 Nov; 37(11):1281-8.Nat Genet2005-10-02T00:00:002005Second-generation shRNA libraries covering the mouse and human genomes.16901786Zhang D, Zaugg K, Mak TW, Elledge SJCellA role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell. 2006 Aug 11; 126(3):529-42.Cell2006-08-11T00:00:002006A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response.22219365Tan X, Lu ZJ, Gao G, Xu Q, Hu L, Fellmann C, Li MZ, Qu H, Lowe SW, Hannon GJ, Elledge SJProceedings of the National Academy of Sciences of the United States of AmericaTiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):869-74.Proc Natl Acad Sci U S A2012-01-04T00:00:002012Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy.22628553Solimini NL, Xu Q, Mermel CH, Liang AC, Schlabach MR, Luo J, Burrows AE, Anselmo AN, Bredemeyer AL, Li MZ, Beroukhim R, Meyerson M, Elledge SJScience (New York, N.Y.)Recurrent hemizygous deletions in cancers may optimize proliferative potential. Science. 2012 Jul 06; 337(6090):104-9.Science2012-05-24T00:00:002012Recurrent hemizygous deletions in cancers may optimize proliferative potential.2985547Elledge SJ, Walker GCJournal of bacteriologyPhasmid vectors for identification of genes by complementation of Escherichia coli mutants. J Bacteriol. 1985 May; 162(2):777-83.J Bacteriol1985-05-01T00:00:001985Phasmid vectors for identification of genes by complementation of Escherichia coli mutants.9606978Elledge SJ, Harper JWBiochimica et biophysica actaThe role of protein stability in the cell cycle and cancer. Biochim Biophys Acta. 1998 Apr 17; 1377(2):M61-70.Biochim Biophys Acta1998-04-17T00:00:001998The role of protein stability in the cell cycle and cancer.1454852Ramer SW, Elledge SJ, Davis RWProceedings of the National Academy of Sciences of the United States of AmericaDominant genetics using a yeast genomic library under the control of a strong inducible promoter. Proc Natl Acad Sci U S A. 1992 Dec 01; 89(23):11589-93.Proc Natl Acad Sci U S A1992-12-01T00:00:001992Dominant genetics using a yeast genomic library under the control of a strong inducible promoter.10531037Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JWCurrent biology : CBA family of mammalian F-box proteins. Curr Biol. 1999 Oct 21; 9(20):1180-2.Curr Biol1999-10-21T00:00:001999A family of mammalian F-box proteins.1516817Zhou Z, Elledge SJGeneticsIsolation of crt mutants constitutive for transcription of the DNA damage inducible gene RNR3 in Saccharomyces cerevisiae. Genetics. 1992 Aug; 131(4):851-66.Genetics1992-08-01T00:00:001992Isolation of crt mutants constitutive for transcription of the DNA damage inducible gene RNR3 in Saccharomyces cerevisiae.10835638Gripp KW, Wotton D, Edwards MC, Roessler E, Ades L, Meinecke P, Richieri-Costa A, Zackai EH, Massagué J, Muenke M, Elledge SJNature geneticsMutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination. Nat Genet. 2000 Jun; 25(2):205-8.Nat Genet2000-06-01T00:00:002000Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination.