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Griffith JW, Sun T, McIntosh MT, Bucala R
Journal of immunology (Baltimore, Md. : 1950)
Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid. J Immunol. 2009 Oct 15; 183(8):5208-20.
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Quantitative assessment of airway remodelling and response to allergen in asthma. Respirology. 2019 11; 24(11):1073-1080.
Quantitative assessment of airway remodelling and response to allergen in asthma.
Persis, Cyrus and Marlow B. Harrison Professor of Medicine
Denise and David Bunning Professor of Pediatrics in the Field of Allergy and Immunology
Morton Grove-Rasmussen Professor of Immunohematology
Rodríguez-Rodríguez A, Shuvaev S, Rotile N, Jones CM, Probst CK, Dos Santos Ferreira D, Graham-O Regan K, Boros E, Knipe RS, Griffith JW, Tager AM, Bogdanov A, Caravan P
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Peroxidase Sensitive Amplifiable Probe for Molecular Magnetic Resonance Imaging of Pulmonary Inflammation.
Mani V, Bromley SK, Äijö T, Mora-Buch R, Carrizosa E, Warner RD, Hamze M, Sen DR, Chasse AY, Lorant A, Griffith JW, Rahimi RA, McEntee CP, Jeffrey KL, Marangoni F, Travis MA, Lacy-Hulbert A, Luster AD, Mempel TR
Migratory DCs activate TGF-ß to precondition naïve CD8+ T cells for tissue-resident memory fate. Science. 2019 10 11; 366(6462).
Migratory DCs activate TGF-ß to precondition naïve CD8+ T cells for tissue-resident memory fate.
Mendoza DP, Kohli P, Nance JW, Singh R, Cho J, Griffith J, Harris RS, Kelly VJ, Luster AD, Medoff B, Digumarthy SR
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Lung parenchymal and airway changes on CT imaging following allergen challenge and bronchoalveolar lavage in atopic and asthmatic subjects.
Faustino LD, Griffith JW, Rahimi RA, Nepal K, Hamilos DL, Cho JL, Medoff BD, Moon JJ, Vignali DAA, Luster AD
Interleukin-33 activates regulatory T cells to suppress innate ?d T cell responses in the lung. Nat Immunol. 2020 11; 21(11):1371-1383.
Interleukin-33 activates regulatory T cells to suppress innate ?d T cell responses in the lung.
Hariri LP, North CM, Shih AR, Israel RA, Maley JH, Villalba JA, Vinarsky V, Rubin J, Okin DA, Sclafani A, Alladina JW, Griffith JW, Gillette MA, Raz Y, Richards CJ, Wong AK, Ly A, Hung YP, Chivukula RR, Petri CR, Calhoun TF, Brenner LN, Hibbert KA, Medoff BD, Hardin CC, Stone JR, Mino-Kenudson M
Lung Histopathology in Coronavirus Disease 2019 as Compared With Severe Acute Respiratory Sydrome and H1N1 Influenza: A Systematic Review. Chest. 2021 01; 159(1):73-84.
Lung Histopathology in Coronavirus Disease 2019 as Compared With Severe Acute Respiratory Sydrome and H1N1 Influenza: A Systematic Review.
Harb H, Benamar M, Lai PS, Contini P, Griffith JW, Crestani E, Schmitz-Abe K, Chen Q, Fong J, Marri L, Filaci G, Del Zotto G, Pishesha N, Kolifrath S, Broggi A, Ghosh S, Gelmez MY, Oktelik FB, Cetin EA, Kiykim A, Kose M, Wang Z, Cui Y, Yu XG, Li JZ, Berra L, Stephen-Victor E, Charbonnier LM, Zanoni I, Ploegh H, Deniz G, De Palma R, Chatila TA
Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections. Immunity. 2021 06 08; 54(6):1186-1199.e7.
Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections.
Knipe RS, Spinney JJ, Abe EA, Probst CK, Franklin A, Logue A, Giacona F, Drummond M, Griffith J, Brazee PL, Hariri LP, Montesi SB, Black KE, Hla T, Kuo A, Cartier A, Engelbrecht E, Christoffersen C, Shea BS, Tager AM, Medoff BD
American journal of respiratory cell and molecular biology
Endothelial-Specific Loss of Sphingosine-1-Phosphate Receptor 1 Increases Vascular Permeability and Exacerbates Bleomycin-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2022 01; 66(1):38-52.
Endothelial-Specific Loss of Sphingosine-1-Phosphate Receptor 1 Increases Vascular Permeability and Exacerbates Bleomycin-induced Pulmonary Fibrosis.
Villavicencio MA, Li SS, Leifer AM, Gustafson JL, Osho A, Wolfe S, Raz Y, Griffith J, Neuringer I, Bethea E, Gift T, Waldman G, Astor T, Langer NB, Chung RT
Preemptive antiviral therapy in lung transplantation from hepatitis C donors results in a rapid and sustained virologic response. JTCVS Open. 2023 Jun; 14:602-614.
Preemptive antiviral therapy in lung transplantation from hepatitis C donors results in a rapid and sustained virologic response.
Brazee PL, Cartier A, Kuo A, Haring AM, Nguyen T, Hariri LP, Griffith JW, Hla T, Medoff BD, Knipe RS
Augmentation of Endothelial S1PR1 Attenuates Postviral Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2024 Feb; 70(2):119-128.
Augmentation of Endothelial S1PR1 Attenuates Postviral Pulmonary Fibrosis.
Griffith JW, Faustino LD, Cottrell VI, Nepal K, Hariri LP, Chiu RS, Jones MC, Julé A, Gabay C, Luster AD
Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection. Nat Immunol. 2023 12; 24(12):2091-2107.
Regulatory T cell-derived IL-1Ra suppresses the innate response to respiratory viral infection.
Sun T, Holowka T, Song Y, Zierow S, Leng L, Chen Y, Xiong H, Griffith J, Nouraie M, Thuma PE, Lolis E, Janse CJ, Gordeuk VR, Augustijn K, Bucala R
Proceedings of the National Academy of Sciences of the United States of America
A Plasmodium-encoded cytokine suppresses T-cell immunity during malaria. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):E2117-26.
A Plasmodium-encoded cytokine suppresses T-cell immunity during malaria.
Targeting cells in motion: migrating toward improved therapies. Eur J Immunol. 2013 Jun; 43(6):1430-5.
Targeting cells in motion: migrating toward improved therapies.
No bones about it: regulatory T cells promote fracture healing. J Clin Invest. 2025 Jan 16; 135(2).
No bones about it: regulatory T cells promote fracture healing.
Xia P, Lee S, Roh K, Griffith J, Zhou Y, Guzman E, Shi Y, Yang Z, Castro C, Li H, Guo YY, Singh A, Knipe RS, Raji I, Xu JH, Babbs RK, Fisher F, Lachey J, Seehra J, Yu PB, Lee SJ, Anderson DG, Aguirre A, Rosenzweig A, Malhotra R, Roh JD
Endothelial ActRIIA inhibition protects the cardiac microvasculature in severe viral respiratory infection. Res Sq. 2025 Apr 01.
Endothelial ActRIIA inhibition protects the cardiac microvasculature in severe viral respiratory infection.
Chemokines and chemokine receptors: positioning cells for host defense and immunity. Annu Rev Immunol. 2014; 32:659-702.
Chemokines and chemokine receptors: positioning cells for host defense and immunity.
Patricia K. Donahoe Professor of Surgery
McDevitt MA, Xie J, Ganapathy-Kanniappan S, Griffith J, Liu A, McDonald C, Thuma P, Gordeuk VR, Metz CN, Mitchell R, Keefer J, David J, Leng L, Bucala R
A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia. J Exp Med. 2015 May 04; 212(5):825.
A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia.
Ramirez-Ortiz ZG, Prasad A, Griffith JW, Pendergraft WF, Cowley GS, Root DE, Tai M, Luster AD, El Khoury J, Hacohen N, Means TK
The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity. Nat Immunol. 2015 May; 16(5):495-504.
The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.
Adams DC, Hariri LP, Miller AJ, Wang Y, Cho JL, Villiger M, Holz JA, Szabari MV, Hamilos DL, Scott Harris R, Griffith JW, Bouma BE, Luster AD, Medoff BD, Suter MJ
Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo. Sci Transl Med. 2016 10 05; 8(359):359ra131.
Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo.
Cho JL, Ling MF, Adams DC, Faustino L, Islam SA, Afshar R, Griffith JW, Harris RS, Ng A, Radicioni G, Ford AA, Han AK, Xavier R, Kwok WW, Boucher R, Moon JJ, Hamilos DL, Kesimer M, Suter MJ, Medoff BD, Luster AD
Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation. Sci Transl Med. 2016 10 05; 8(359):359ra132.
Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation.
McDevitt MA, Xie J, Ganapathy-Kanniappan S, Shanmugasundaram G, Griffith J, Liu A, McDonald C, Thuma P, Gordeuk VR, Metz CN, Mitchell R, Keefer J, David J, Leng L, Bucala R
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Liang J, Jiang D, Griffith J, Yu S, Fan J, Zhao X, Bucala R, Noble PW
CD44 is a negative regulator of acute pulmonary inflammation and lipopolysaccharide-TLR signaling in mouse macrophages. J Immunol. 2007 Feb 15; 178(4):2469-75.
CD44 is a negative regulator of acute pulmonary inflammation and lipopolysaccharide-TLR signaling in mouse macrophages.
Distinct Function and Control of Regulatory T Cell Subsets During Influenza
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A Leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses. J Immunol. 2008 Jun 15; 180(12):8250-61.
A Leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses.
Gratton JP, Yu J, Griffith JW, Babbitt RW, Scotland RS, Hickey R, Giordano FJ, Sessa WC
Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivo. Nat Med. 2003 Mar; 9(3):357-62.
Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivo.