Director, Pharmacogenomics Research, Department of Psychiatry and Center for Human Genetic Research, Massachusetts General Hospital Medical Director, Bipolar Clinic and Research Program, Massachusetts General Hospital
McCoy TH, Yu S, Hart KL, Castro VM, Brown HE, Rosenquist JN, Doyle AE, Vuijk PJ, Cai T, Perlis RH
High Throughput Phenotyping for Dimensional Psychopathology in Electronic Health Records. Biol Psychiatry. 2018 06 15; 83(12):997-1004.
High Throughput Phenotyping for Dimensional Psychopathology in Electronic Health Records.
McCoy TH, Castro VM, Hart KL, Pellegrini AM, Yu S, Cai T, Perlis RH
Genome-wide Association Study of Dimensional Psychopathology Using Electronic Health Records. Biol Psychiatry. 2018 06 15; 83(12):1005-1011.
Genome-wide Association Study of Dimensional Psychopathology Using Electronic Health Records.
Sullivan PF, de Geus EJ, Willemsen G, James MR, Smit JH, Zandbelt T, Arolt V, Baune BT, Blackwood D, Cichon S, Coventry WL, Domschke K, Farmer A, Fava M, Gordon SD, He Q, Heath AC, Heutink P, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hu Y, Kohli M, Lin D, Lucae S, Macintyre DJ, Maier W, McGhee KA, McGuffin P, Montgomery GW, Muir WJ, Nolen WA, Nöthen MM, Perlis RH, Pirlo K, Posthuma D, Rietschel M, Rizzu P, Schosser A, Smit AB, Smoller JW, Tzeng JY, van Dyck R, Verhage M, Zitman FG, Martin NG, Wray NR, Boomsma DI, Penninx BW
Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol Psychiatry. 2009 Apr; 14(4):359-75.
Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo.
Smoller JW, Biederman J, Arbeitman L, Doyle AE, Fagerness J, Perlis RH, Sklar P, Faraone SV
Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHD. Biol Psychiatry. 2006 Mar 01; 59(5):460-7.
Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHD.
Casamassima F, Huang J, Fava M, Sachs GS, Smoller JW, Cassano GB, Lattanzi L, Fagerness J, Stange JP, Perlis RH
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
Phenotypic effects of a bipolar liability gene among individuals with major depressive disorder. Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 05; 153B(1):303-9.
Phenotypic effects of a bipolar liability gene among individuals with major depressive disorder.
Perlis RH, Smoller JW, Ferreira MA, McQuillin A, Bass N, Lawrence J, Sachs GS, Nimgaonkar V, Scolnick EM, Gurling H, Sklar P, Purcell S
A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder. Am J Psychiatry. 2009 Jun; 166(6):718-25.
A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder.
Sagers JE, Brown AS, Vasilijic S, Lewis RM, Sahin MI, Landegger LD, Perlis RH, Kohane IS, Welling DB, Patel CJ, Stankovic KM
Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma. Sci Rep. 2018 04 03; 8(1):5437.
Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma.
Perlis RH, Purcell S, Fagerness J, Cusin C, Yamaki L, Fava M, Smoller JW
Clinical and genetic dissection of anger expression and CREB1 polymorphisms in major depressive disorder. Biol Psychiatry. 2007 Sep 01; 62(5):536-40.
Clinical and genetic dissection of anger expression and CREB1 polymorphisms in major depressive disorder.
Personalized medicine for depression: can we match patients with treatments? Am J Psychiatry. 2010 Dec; 167(12):1445-55.
Personalized medicine for depression: can we match patients with treatments?
Casamassima F, Hay AC, Benedetti A, Lattanzi L, Cassano GB, Perlis RH
L-type calcium channels and psychiatric disorders: A brief review. Am J Med Genet B Neuropsychiatr Genet. 2010 Dec 05; 153B(8):1373-90.
L-type calcium channels and psychiatric disorders: A brief review.
Freedman R, Brown AS, Cannon TD, Druss BG, Earls FJ, Escobar J, Hurd YL, Lewis DA, López-Jaramillo C, Luby J, Mayberg HS, Moffitt TE, Oquendo M, Perlis RH, Pine DS, Rush AJ, Tamminga CA, Tohen M, Vieta E, Wisner KL, Xin Y
Can a Framework Be Established for the Safe Use of Ketamine? Am J Psychiatry. 2018 07 01; 175(7):587-589.
Can a Framework Be Established for the Safe Use of Ketamine?
McCoy TH, Hart K, Pellegrini A, Perlis RH
Genome-wide association identifies a novel locus for delirium risk. Neurobiol Aging. 2018 08; 68:160.e9-160.e14.
Genome-wide association identifies a novel locus for delirium risk.
Chen CY, Lee PH, Castro VM, Minnier J, Charney AW, Stahl EA, Ruderfer DM, Murphy SN, Gainer V, Cai T, Jones I, Pato CN, Pato MT, Landén M, Sklar P, Perlis RH, Smoller JW
Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records. Transl Psychiatry. 2018 04 18; 8(1):86.
Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records.
Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, Adams MJ, Agerbo E, Air TM, Andlauer TMF, Bacanu SA, Bækvad-Hansen M, Beekman AFT, Bigdeli TB, Binder EB, Blackwood DRH, Bryois J, Buttenschøn HN, Bybjerg-Grauholm J, Cai N, Castelao E, Christensen JH, Clarke TK, Coleman JIR, Colodro-Conde L, Couvy-Duchesne B, Craddock N, Crawford GE, Crowley CA, Dashti HS, Davies G, Deary IJ, Degenhardt F, Derks EM, Direk N, Dolan CV, Dunn EC, Eley TC, Eriksson N, Escott-Price V, Kiadeh FHF, Finucane HK, Forstner AJ, Frank J, Gaspar HA, Gill M, Giusti-Rodríguez P, Goes FS, Gordon SD, Grove J, Hall LS, Hannon E, Hansen CS, Hansen TF, Herms S, Hickie IB, Hoffmann P, Homuth G, Horn C, Hottenga JJ, Hougaard DM, Hu M, Hyde CL, Ising M, Jansen R, Jin F, Jorgenson E, Knowles JA, Kohane IS, Kraft J, Kretzschmar WW, Krogh J, Kutalik Z, Lane JM, Li Y, Li Y, Lind PA, Liu X, Lu L, MacIntyre DJ, MacKinnon DF, Maier RM, Maier W, Marchini J, Mbarek H, McGrath P, McGuffin P, Medland SE, Mehta D, Middeldorp CM, Mihailov E, Milaneschi Y, Milani L, Mill J, Mondimore FM, Montgomery GW, Mostafavi S, Mullins N, Nauck M, Ng B, Nivard MG, Nyholt DR, O'Reilly PF, Oskarsson H, Owen MJ, Painter JN, Pedersen CB, Pedersen MG, Peterson RE, Pettersson E, Peyrot WJ, Pistis G, Posthuma D, Purcell SM, Quiroz JA, Qvist P, Rice JP, Riley BP, Rivera M, Saeed Mirza S, Saxena R, Schoevers R, Schulte EC, Shen L, Shi J, Shyn SI, Sigurdsson E, Sinnamon GBC, Smit JH, Smith DJ, Stefansson H, Steinberg S, Stockmeier CA, Streit F, Strohmaier J, Tansey KE, Teismann H, Teumer A, Thompson W, Thomson PA, Thorgeirsson TE, Tian C, Traylor M, Treutlein J, Trubetskoy V, Uitterlinden AG, Umbricht D, Van der Auwera S, van Hemert AM, Viktorin A, Visscher PM, Wang Y, Webb BT, Weinsheimer SM, Wellmann J, Willemsen G, Witt SH, Wu Y, Xi HS, Yang J, Zhang F, Arolt V, Baune BT, Berger K, Boomsma DI, Cichon S, Dannlowski U, de Geus ECJ, DePaulo JR, Domenici E, Domschke K, Esko T, Grabe HJ, Hamilton SP, Hayward C, Heath AC, Hinds DA, Kendler KS, Kloiber S, Lewis G, Li QS, Lucae S, Madden PFA, Magnusson PK, Martin NG, McIntosh AM, Metspalu A, Mors O, Mortensen PB, Müller-Myhsok B, Nordentoft M, Nöthen MM, O'Donovan MC, Paciga SA, Pedersen NL, Penninx BWJH, Perlis RH, Porteous DJ, Potash JB, Preisig M, Rietschel M, Schaefer C, Schulze TG, Smoller JW, Stefansson K, Tiemeier H, Uher R, Völzke H, Weissman MM, Werge T, Winslow AR, Lewis CM, Levinson DF, Breen G, Børglum AD, Sullivan PF
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet. 2018 05; 50(5):668-681.
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.
Anxiety About Antidepressants. Am J Psychiatry. 2018 06 01; 175(6):500-501.
Smoller JW, Allison M, Cochrane BB, Curb JD, Perlis RH, Robinson JG, Rosal MC, Wenger NK, Wassertheil-Smoller S
Antidepressant use and risk of incident cardiovascular morbidity and mortality among postmenopausal women in the Women's Health Initiative study. Arch Intern Med. 2009 Dec 14; 169(22):2128-39.
Antidepressant use and risk of incident cardiovascular morbidity and mortality among postmenopausal women in the Women's Health Initiative study.
Perlis RH, Ostacher M, Fava M, Nierenberg AA, Sachs GS, Rosenbaum JF
Assuring that double-blind is blind. Am J Psychiatry. 2010 Mar; 167(3):250-2.
Wu Y, Deboeck P, Joseph M, Hwang C, Perlis CS, Perlis RH
Does study design explain the relationship between conflict of interest and positive outcome in clinical trials in psychiatry? J Clin Psychopharmacol. 2009 Dec; 29(6):609-11.
Does study design explain the relationship between conflict of interest and positive outcome in clinical trials in psychiatry?
Perlis RH, Adams DH, Fijal B, Sutton VK, Farmen M, Breier A, Houston JP
Genetic association study of treatment response with olanzapine/fluoxetine combination or lamotrigine in bipolar I depression. J Clin Psychiatry. 2010 May; 71(5):599-605.
Genetic association study of treatment response with olanzapine/fluoxetine combination or lamotrigine in bipolar I depression.
Perlis RH, Fijal B, Dharia S, Heinloth AN, Houston JP
Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients. Biol Psychiatry. 2010 Jun 01; 67(11):1110-3.
Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients.
Dupuy JM, Ostacher MJ, Huffman J, Perlis RH, Nierenberg AA
The international journal of neuropsychopharmacology
A critical review of pharmacotherapy for major depressive disorder. Int J Neuropsychopharmacol. 2011 Nov; 14(10):1417-31.
A critical review of pharmacotherapy for major depressive disorder.
Nierenberg AA, Kansky C, Brennan BP, Shelton RC, Perlis R, Iosifescu DV
The Australian and New Zealand journal of psychiatry
Mitochondrial modulators for bipolar disorder: a pathophysiologically informed paradigm for new drug development. Aust N Z J Psychiatry. 2013 Jan; 47(1):26-42.
Mitochondrial modulators for bipolar disorder: a pathophysiologically informed paradigm for new drug development.
Perlis RH, Ostacher MJ, Patel JK, Marangell LB, Zhang H, Wisniewski SR, Ketter TA, Miklowitz DJ, Otto MW, Gyulai L, Reilly-Harrington NA, Nierenberg AA, Sachs GS, Thase ME
Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Am J Psychiatry. 2006 Feb; 163(2):217-24.
Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD).
Perlis RH, Mehta R, Edwards AM, Tiwari A, Imbens GW
Pharmacogenetic testing among patients with mood and anxiety disorders is associated with decreased utilization and cost: A propensity-score matched study. Depress Anxiety. 2018 10; 35(10):946-952.
Pharmacogenetic testing among patients with mood and anxiety disorders is associated with decreased utilization and cost: A propensity-score matched study.
Dillon DG, Bogdan R, Fagerness J, Holmes AJ, Perlis RH, Pizzagalli DA
Variation in TREK1 gene linked to depression-resistant phenotype is associated with potentiated neural responses to rewards in humans. Hum Brain Mapp. 2010 Feb; 31(2):210-21.
Variation in TREK1 gene linked to depression-resistant phenotype is associated with potentiated neural responses to rewards in humans.
Craddock N, Kendler K, Neale M, Nurnberger J, Purcell S, Rietschel M, Perlis R, Santangelo SL, Schulze TG, Schulze T, Smoller JW, Thapar A
The British journal of psychiatry : the journal of mental science
Dissecting the phenotype in genome-wide association studies of psychiatric illness. Br J Psychiatry. 2009 Aug; 195(2):97-9.
Dissecting the phenotype in genome-wide association studies of psychiatric illness.
Biomarkers predicting treatment outcome in depression: what is clinically significant? Pharmacogenomics. 2012 Jan; 13(2):233-40.
Biomarkers predicting treatment outcome in depression: what is clinically significant?
Proposed DSM-5 mixed features are associated with greater likelihood of remission in out-patients with major depressive disorder. Psychol Med. 2014 May; 44(7):1361-7.
Proposed DSM-5 mixed features are associated with greater likelihood of remission in out-patients with major depressive disorder.
Brown HE, Hart KL, Snapper LA, Roffman JL, Perlis RH
Impairment in delay discounting in schizophrenia and schizoaffective disorder but not primary mood disorders. NPJ Schizophr. 2018 May 28; 4(1):9.
Impairment in delay discounting in schizophrenia and schizoaffective disorder but not primary mood disorders.
Perlis RH, Mischoulon D, Smoller JW, Wan YJ, Lamon-Fava S, Lin KM, Rosenbaum JF, Fava M
Serotonin transporter polymorphisms and adverse effects with fluoxetine treatment. Biol Psychiatry. 2003 Nov 01; 54(9):879-83.
Serotonin transporter polymorphisms and adverse effects with fluoxetine treatment.
Betting on biomarkers. Am J Psychiatry. 2011 Mar; 168(3):234-6.
Houston JP, Kohler J, Ostbye KM, Heinloth A, Perlis RH
Association of catechol-O-methyltransferase variants with duloxetine response in major depressive disorder. Psychiatry Res. 2011 Oct 30; 189(3):475-7.
Association of catechol-O-methyltransferase variants with duloxetine response in major depressive disorder.
Houston JP, Lau K, Aris V, Liu W, Fijal BA, Heinloth AN, Perlis RH
Association of common variations in the norepinephrine transporter gene with response to olanzapine-fluoxetine combination versus continued-fluoxetine treatment in patients with treatment-resistant depression: a candidate gene analysis. J Clin Psychiatry. 2012 Jun; 73(6):878-85.
Association of common variations in the norepinephrine transporter gene with response to olanzapine-fluoxetine combination versus continued-fluoxetine treatment in patients with treatment-resistant depression: a candidate gene analysis.
No Association Between Antidepressant Efficacy and rs28365143 in Corticotropin-Releasing Hormone Binding Protein in a Large Meta-Analysis. Am J Psychiatry. 2018 06 01; 175(6):575-576.
No Association Between Antidepressant Efficacy and rs28365143 in Corticotropin-Releasing Hormone Binding Protein in a Large Meta-Analysis.
Kim JW, Biederman J, Arbeitman L, Fagerness J, Doyle AE, Petty C, Perlis RH, Purcell S, Smoller JW, Faraone SV, Sklar P
Investigation of variation in SNAP-25 and ADHD and relationship to co-morbid major depressive disorder. Am J Med Genet B Neuropsychiatr Genet. 2007 Sep 05; 144B(6):781-90.
Investigation of variation in SNAP-25 and ADHD and relationship to co-morbid major depressive disorder.
The Psychiatric clinics of North America
Biological predictors of treatment response in affective illness. Psychiatr Clin North Am. 2003 Jun; 26(2):323-44, vii.
Biological predictors of treatment response in affective illness.
Reinbold CS, Forstner AJ, Hecker J, Fullerton JM, Hoffmann P, Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Marie-Claire C, Cervantes P, Chen GB, Chen HC, Chillotti C, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dayer A, Étain B, Falkai P, Frisén L, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Jamain S, Jiménez E, Kahn JP, Kassem L, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Lackner N, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, López Jaramillo CA, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Ösby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemüller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller JW, Squassina A, Stamm TJ, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt SH, Wright AJ, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus E, Novák T, Aubry JM, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo PH, Kato T, Grigoroiu-Serbanescu M, Reif A, Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe JR, Alda M, McMahon FJ, Schulze TG, Rietschel M, Nöthen MM, Cichon S
Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder. Front Psychiatry. 2018; 9:207.
Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder.
Huang J, Perlis RH, Lee PH, Rush AJ, Fava M, Sachs GS, Lieberman J, Hamilton SP, Sullivan P, Sklar P, Purcell S, Smoller JW
Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression. Am J Psychiatry. 2010 Oct; 167(10):1254-63.
Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression.
Willour VL, Seifuddin F, Mahon PB, Jancic D, Pirooznia M, Steele J, Schweizer B, Goes FS, Mondimore FM, Mackinnon DF, Perlis RH, Lee PH, Huang J, Kelsoe JR, Shilling PD, Rietschel M, Nöthen M, Cichon S, Gurling H, Purcell S, Smoller JW, Craddock N, DePaulo JR, Schulze TG, McMahon FJ, Zandi PP, Potash JB
A genome-wide association study of attempted suicide. Mol Psychiatry. 2012 Apr; 17(4):433-44.
A genome-wide association study of attempted suicide.
Kloiber S, Ripke S, Kohli MA, Reppermund S, Salyakina D, Uher R, McGuffin P, Perlis RH, Hamilton SP, Pütz B, Hennings J, Brückl T, Klengel T, Bettecken T, Ising M, Uhr M, Dose T, Unschuld PG, Zihl J, Binder E, Müller-Myhsok B, Holsboer F, Lucae S
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels. Eur Neuropsychopharmacol. 2013 Jul; 23(7):653-62.
Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels.
Iosifescu DV, Greenwald S, Devlin P, Perlis RH, Denninger JW, Alpert JE, Fava M
Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder. Acta Psychiatr Scand. 2008 Apr; 117(4):271-6.
Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder.
Perlis RH, Huang J, Purcell S, Fava M, Rush AJ, Sullivan PF, Hamilton SP, McMahon FJ, Schulze TG, Schulze T, Potash JB, Zandi PP, Willour VL, Penninx BW, Boomsma DI, Vogelzangs N, Middeldorp CM, Rietschel M, Nöthen M, Cichon S, Gurling H, Bass N, McQuillin A, Hamshere M, Craddock N, Sklar P, Smoller JW
Genome-wide association study of suicide attempts in mood disorder patients. Am J Psychiatry. 2010 Dec; 167(12):1499-507.
Genome-wide association study of suicide attempts in mood disorder patients.
Snapper LA, Hart KL, Venkatesh KK, Kaimal AJ, Perlis RH
Cohort study of the relationship between individual psychotherapy and pregnancy outcomes. J Affect Disord. 2018 10 15; 239:253-257.
Cohort study of the relationship between individual psychotherapy and pregnancy outcomes.
Use of treatment guidelines in clinical decision making in bipolar disorder: a pilot survey of clinicians. Curr Med Res Opin. 2007 Mar; 23(3):467-75.
Use of treatment guidelines in clinical decision making in bipolar disorder: a pilot survey of clinicians.
Review: adding second generation antipsychotics to mood stabilisers reduces acute mania symptoms. Evid Based Ment Health. 2007 Nov; 10(4):111.
Review: adding second generation antipsychotics to mood stabilisers reduces acute mania symptoms.
Perlis RH, Fijal B, Adams DH, Sutton VK, Trivedi MH, Houston JP
Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder. Biol Psychiatry. 2009 May 01; 65(9):785-91.
Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder.
Fabbri C, Tansey KE, Perlis RH, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Breen G, Curtis C, Lee SH, Newhouse S, Patel H, O'Donovan M, Lewis G, Jenkins G, Weinshilboum RM, Farmer A, Aitchison KJ, Craig I, McGuffin P, Schruers K, Biernacka JM, Uher R, Lewis CM
Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies. Eur Neuropsychopharmacol. 2018 08; 28(8):945-954.
Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies.
Perlis RH, Patrick A, Smoller JW, Wang PS
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
When is pharmacogenetic testing for antidepressant response ready for the clinic? A cost-effectiveness analysis based on data from the STAR*D study. Neuropsychopharmacology. 2009 Sep; 34(10):2227-36.
When is pharmacogenetic testing for antidepressant response ready for the clinic? A cost-effectiveness analysis based on data from the STAR*D study.
Schulze TG, Alda M, Adli M, Akula N, Ardau R, Bui ET, Chillotti C, Cichon S, Czerski P, Del Zompo M, Detera-Wadleigh SD, Grof P, Gruber O, Hashimoto R, Hauser J, Hoban R, Iwata N, Kassem L, Kato T, Kittel-Schneider S, Kliwicki S, Kelsoe JR, Kusumi I, Laje G, Leckband SG, Manchia M, Macqueen G, Masui T, Ozaki N, Perlis RH, Pfennig A, Piccardi P, Richardson S, Rouleau G, Reif A, Rybakowski JK, Sasse J, Schumacher J, Severino G, Smoller JW, Squassina A, Turecki G, Young LT, Yoshikawa T, Bauer M, McMahon FJ
The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment. Neuropsychobiology. 2010; 62(1):72-8.
The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment.
Risks for the transition from major depressive disorder to bipolar disorder in the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry. 2012 Jun; 73(6):829-36.
Risks for the transition from major depressive disorder to bipolar disorder in the National Epidemiologic Survey on Alcohol and Related Conditions.
Castro VM, Gallagher PJ, Clements CC, Murphy SN, Gainer VS, Fava M, Weilburg JB, Churchill SE, Kohane IS, Iosifescu DV, Smoller JW, Perlis RH
Incident user cohort study of risk for gastrointestinal bleed and stroke in individuals with major depressive disorder treated with antidepressants. BMJ Open. 2012; 2(2):e000544.
Incident user cohort study of risk for gastrointestinal bleed and stroke in individuals with major depressive disorder treated with antidepressants.
Lee PH, Bergen SE, Perlis RH, Sullivan PF, Sklar P, Smoller JW, Purcell SM
Modifiers and subtype-specific analyses in whole-genome association studies: a likelihood framework. Hum Hered. 2011; 72(1):10-20.
Modifiers and subtype-specific analyses in whole-genome association studies: a likelihood framework.
Do suicidal thoughts or behaviors recur during a second antidepressant treatment trial? J Clin Psychiatry. 2012 Nov; 73(11):1439-42.
Do suicidal thoughts or behaviors recur during a second antidepressant treatment trial?
Temporal Trends and Characteristics of Reportable Health Data Breaches, 2010-2017. JAMA. 2018 09 25; 320(12):1282-1284.
Temporal Trends and Characteristics of Reportable Health Data Breaches, 2010-2017.
Deckersbach T, Perlis RH, Frankle WG, Gray SM, Grandin L, Dougherty DD, Nierenberg AA, Sachs GS
Presence of irritability during depressive episodes in bipolar disorder. CNS Spectr. 2004 Mar; 9(3):227-31.
Presence of irritability during depressive episodes in bipolar disorder.
Perlis RH, Ganz DA, Avorn J, Schneeweiss S, Glynn RJ, Smoller JW, Wang PS
Pharmacogenetic testing in the clinical management of schizophrenia: a decision-analytic model. J Clin Psychopharmacol. 2005 Oct; 25(5):427-34.
Pharmacogenetic testing in the clinical management of schizophrenia: a decision-analytic model.
Pharmacogenetics, race, and psychiatry: prospects and challenges. Harv Rev Psychiatry. 2006 Mar-Apr; 14(2):92-108.
Pharmacogenetics, race, and psychiatry: prospects and challenges.
Ostacher MJ, Nierenberg AA, Perlis RH, Eidelman P, Borrelli DJ, Tran TB, Marzilli Ericson G, Weiss RD, Sachs GS
The relationship between smoking and suicidal behavior, comorbidity, and course of illness in bipolar disorder. J Clin Psychiatry. 2006 Dec; 67(12):1907-11.
The relationship between smoking and suicidal behavior, comorbidity, and course of illness in bipolar disorder.
Treatment of bipolar disorder: the evolving role of atypical antipsychotics. Am J Manag Care. 2007 Nov; 13(7 Suppl):S178-88.
Treatment of bipolar disorder: the evolving role of atypical antipsychotics.
Goldberg JF, Perlis RH, Bowden CL, Thase ME, Miklowitz DJ, Marangell LB, Calabrese JR, Nierenberg AA, Sachs GS
Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: findings from the STEP-BD. Am J Psychiatry. 2009 Feb; 166(2):173-81.
Manic symptoms during depressive episodes in 1,380 patients with bipolar disorder: findings from the STEP-BD.
Farabaugh A, Alpert J, Wisniewski SR, Otto MW, Fava M, Baer L, Perlis R, Friedman E, Nyer M, Bitran S, Balasubramani GK, Inamori A, Trivedi M, Thase ME
Cognitive therapy for anxious depression in STAR(*) D: what have we learned? J Affect Disord. 2012 Dec 15; 142(1-3):213-8.
Cognitive therapy for anxious depression in STAR(*) D: what have we learned?
Gallagher PJ, Castro V, Fava M, Weilburg JB, Murphy SN, Gainer VS, Churchill SE, Kohane IS, Iosifescu DV, Smoller JW, Perlis RH
Antidepressant response in patients with major depression exposed to NSAIDs: a pharmacovigilance study. Am J Psychiatry. 2012 Oct; 169(10):1065-72.
Antidepressant response in patients with major depression exposed to NSAIDs: a pharmacovigilance study.
Journal of the American Academy of Dermatology
Conflict of interest and citation impact among dermatology guideline authors. J Am Acad Dermatol. 2019 03; 80(3):813-815.
Conflict of interest and citation impact among dermatology guideline authors.
Can electronic health records revive central nervous system clinical trials? Mol Psychiatry. 2019 08; 24(8):1096-1098.
Can electronic health records revive central nervous system clinical trials?
Publisher Correction: Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma. Sci Rep. 2018 Nov 23; 8(1):17449.
Publisher Correction: Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma.
Williamson D, Brown E, Perlis RH, Ahl J, Baker RW, Tohen M
Clinical relevance of depressive symptom improvement in bipolar I depressed patients. J Affect Disord. 2006 Jun; 92(2-3):261-6.
Clinical relevance of depressive symptom improvement in bipolar I depressed patients.
Zakut R, Perlis R, Eliyahu S, Yarden Y, Givol D, Lyman SD, Halaban R
KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells. Oncogene. 1993 Aug; 8(8):2221-9.
KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells.
Clinical decision making in the treatment of mania. J Clin Psychiatry. 2008; 69 Suppl 5:16-21.
Clinical decision making in the treatment of mania.
Gilbert TM, Zürcher NR, Wu CJ, Bhanot A, Hightower BG, Kim M, Albrecht DS, Wey HY, Schroeder FA, Rodriguez-Thompson A, Morin TM, Hart KL, Pellegrini AM, Riley MM, Wang C, Stufflebeam SM, Haggarty SJ, Holt DJ, Loggia ML, Perlis RH, Brown HE, Roffman JL, Hooker JM
PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia. J Clin Invest. 2019 01 02; 129(1):364-372.
PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia.
Machine learning for data-driven subtyping of major depression
1/2 Leveraging electronic health records for pharmacogenomics of psychiatric disorders
Perlis RH, Perlis CS, Wu Y, Hwang C, Joseph M, Nierenberg AA
Industry sponsorship and financial conflict of interest in the reporting of clinical trials in psychiatry. Am J Psychiatry. 2005 Oct; 162(10):1957-60.
Industry sponsorship and financial conflict of interest in the reporting of clinical trials in psychiatry.
Perlis RH, Beasley CM, Wines JD, Tamura RN, Cusin C, Shear D, Amsterdam J, Quitkin F, Strong RE, Rosenbaum JF, Fava M
Treatment-associated suicidal ideation and adverse effects in an open, multicenter trial of fluoxetine for major depressive episodes. Psychother Psychosom. 2007; 76(1):40-6.
Treatment-associated suicidal ideation and adverse effects in an open, multicenter trial of fluoxetine for major depressive episodes.
Gordon DD, Patel I, Pellegrini AM, Perlis RH
Prevalence and Nature of Financial Considerations Documented in Narrative Clinical Records in Intensive Care Units. JAMA Netw Open. 2018 11 02; 1(7):e184178.
Prevalence and Nature of Financial Considerations Documented in Narrative Clinical Records in Intensive Care Units.
Assessment of Time-Series Machine Learning Methods for Forecasting Hospital Discharge Volume. JAMA Netw Open. 2018 11 02; 1(7):e184087.
Assessment of Time-Series Machine Learning Methods for Forecasting Hospital Discharge Volume.
Advancing Health and Health Care Using Machine Learning: JAMA Network Open Call for Papers. JAMA Netw Open. 2018 Dec 07; 1(8):e187176.
Advancing Health and Health Care Using Machine Learning: JAMA Network Open Call for Papers.
Perlis RH, Ostacher MJ, Miklowitz DJ, Hay A, Nierenberg AA, Thase ME, Sachs GS
Clinical features associated with poor pharmacologic adherence in bipolar disorder: results from the STEP-BD study. J Clin Psychiatry. 2010 Mar; 71(3):296-303.
Clinical features associated with poor pharmacologic adherence in bipolar disorder: results from the STEP-BD study.
Casamassima F, Lattanzi L, Perlis RH, Litta A, Fui E, Bonuccelli U, Fricchione G, Cassano GB
Neuroleptic malignant syndrome: further lessons from a case report. Psychosomatics. 2010 Jul-Aug; 51(4):349-54.
Neuroleptic malignant syndrome: further lessons from a case report.
Blood AJ, Iosifescu DV, Makris N, Perlis RH, Kennedy DN, Dougherty DD, Kim BW, Lee MJ, Wu S, Lee S, Calhoun J, Hodge SM, Fava M, Rosen BR, Smoller JW, Gasic GP, Breiter HC
Microstructural abnormalities in subcortical reward circuitry of subjects with major depressive disorder. PLoS One. 2010 Nov 29; 5(11):e13945.
Microstructural abnormalities in subcortical reward circuitry of subjects with major depressive disorder.
McCoy TH, Fragomen AT, Hart KL, Pellegrini AM, Raskin KA, Perlis RH
Genomewide Association Study of Fracture Nonunion Using Electronic Health Records. JBMR Plus. 2019 Jan; 3(1):23-28.
Genomewide Association Study of Fracture Nonunion Using Electronic Health Records.
Shao Z, Noh H, Bin Kim W, Ni P, Nguyen C, Cote SE, Noyes E, Zhao J, Parsons T, Park JM, Zheng K, Park JJ, Coyle JT, Weinberger DR, Straub RE, Berman KF, Apud J, Ongur D, Cohen BM, McPhie DL, Rapoport JL, Perlis RH, Lanz TA, Xi HS, Yin C, Huang W, Hirayama T, Fukuda E, Yagi T, Ghosh S, Eggan KC, Kim HY, Eisenberg LM, Moghadam AA, Stanton PK, Cho JH, Chung S
Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia. Nat Neurosci. 2019 02; 22(2):229-242.
Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia.
Sylvia LG, Dupuy JM, Ostacher MJ, Cowperthwait CM, Hay AC, Sachs GS, Nierenberg AA, Perlis RH
Journal of psychopharmacology (Oxford, England)
Sleep disturbance in euthymic bipolar patients. J Psychopharmacol. 2012 Aug; 26(8):1108-12.
Sleep disturbance in euthymic bipolar patients.
Perlis RH, Ruderfer D, Hamilton SP, Ernst C
Copy number variation in subjects with major depressive disorder who attempted suicide. PLoS One. 2012; 7(9):e46315.
Copy number variation in subjects with major depressive disorder who attempted suicide.
Hart KL, Brown HE, Roffman JL, Perlis RH
Risk tolerance measured by probability discounting among individuals with primary mood and psychotic disorders. Neuropsychology. 2019 Mar; 33(3):417-424.
Risk tolerance measured by probability discounting among individuals with primary mood and psychotic disorders.
Sellgren CM, Gracias J, Jungholm O, Perlis RH, Engberg G, Schwieler L, Landen M, Erhardt S
Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls. Transl Psychiatry. 2019 01 29; 9(1):37.
Peripheral and central levels of kynurenic acid in bipolar disorder subjects and healthy controls.
Charney AW, Stahl EA, Green EK, Chen CY, Moran JL, Chambert K, Belliveau RA, Forty L, Gordon-Smith K, Lee PH, Bromet EJ, Buckley PF, Escamilla MA, Fanous AH, Fochtmann LJ, Lehrer DS, Malaspina D, Marder SR, Morley CP, Nicolini H, Perkins DO, Rakofsky JJ, Rapaport MH, Medeiros H, Sobell JL, Backlund L, Bergen SE, Juréus A, Schalling M, Lichtenstein P, Knowles JA, Burdick KE, Jones I, Jones LA, Hultman CM, Perlis R, Purcell SM, McCarroll SA, Pato CN, Pato MT, Di Florio A, Craddock N, Landén M, Smoller JW, Ruderfer DM, Sklar P
Contribution of Rare Copy Number Variants to Bipolar Disorder Risk Is Limited to Schizoaffective Cases. Biol Psychiatry. 2019 07 15; 86(2):110-119.
Contribution of Rare Copy Number Variants to Bipolar Disorder Risk Is Limited to Schizoaffective Cases.
Using phenome-wide association to investigate the function of a schizophrenia risk locus at SLC39A8. Transl Psychiatry. 2019 01 29; 9(1):45.
Using phenome-wide association to investigate the function of a schizophrenia risk locus at SLC39A8.
Sellgren CM, Gracias J, Watmuff B, Biag JD, Thanos JM, Whittredge PB, Fu T, Worringer K, Brown HE, Wang J, Kaykas A, Karmacharya R, Goold CP, Sheridan SD, Perlis RH
Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning. Nat Neurosci. 2019 03; 22(3):374-385.
Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning.
Research Domain Criteria scores estimated through natural language processing are associated with risk for suicide and accidental death. Depress Anxiety. 2019 05; 36(5):392-399.
Research Domain Criteria scores estimated through natural language processing are associated with risk for suicide and accidental death.
Moran LV, Ongur D, Hsu J, Castro VM, Perlis RH, Schneeweiss S
Psychosis with Methylphenidate or Amphetamine in Patients with ADHD. N Engl J Med. 2019 03 21; 380(12):1128-1138.
Psychosis with Methylphenidate or Amphetamine in Patients with ADHD.
McDermott MBA, Wang J, Zhao WN, Sheridan SD, Szolovits P, Kohane I, Haggarty SJ, Perlis RH
IEEE/ACM transactions on computational biology and bioinformatics
Deep Learning Benchmarks on L1000 Gene Expression Data. IEEE/ACM Trans Comput Biol Bioinform. 2020 Nov-Dec; 17(6):1846-1857.
Deep Learning Benchmarks on L1000 Gene Expression Data.
Gender Trends in Authorship in Psychiatry Journals From 2008 to 2018. Biol Psychiatry. 2019 10 15; 86(8):639-646.
Gender Trends in Authorship in Psychiatry Journals From 2008 to 2018.
Brown HE, Freudenreich O, Fan X, Heard SO, Goff D, Petrides G, Harrington AL, Kane JM, Judge H, Hoeppner B, Fava M, Perlis RH
Efficacy and Tolerability of Adjunctive Intravenous Sodium Nitroprusside Treatment for Outpatients With Schizophrenia: A Randomized Clinical Trial. JAMA Psychiatry. 2019 07 01; 76(7):691-699.
Efficacy and Tolerability of Adjunctive Intravenous Sodium Nitroprusside Treatment for Outpatients With Schizophrenia: A Randomized Clinical Trial.
Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V, Mattheisen M, Wang Y, Coleman JRI, Gaspar HA, de Leeuw CA, Steinberg S, Pavlides JMW, Trzaskowski M, Byrne EM, Pers TH, Holmans PA, Richards AL, Abbott L, Agerbo E, Akil H, Albani D, Alliey-Rodriguez N, Als TD, Anjorin A, Antilla V, Awasthi S, Badner JA, Bækvad-Hansen M, Barchas JD, Bass N, Bauer M, Belliveau R, Bergen SE, Pedersen CB, Bøen E, Boks MP, Boocock J, Budde M, Bunney W, Burmeister M, Bybjerg-Grauholm J, Byerley W, Casas M, Cerrato F, Cervantes P, Chambert K, Charney AW, Chen D, Churchhouse C, Clarke TK, Coryell W, Craig DW, Cruceanu C, Curtis D, Czerski PM, Dale AM, de Jong S, Degenhardt F, Del-Favero J, DePaulo JR, Djurovic S, Dobbyn AL, Dumont A, Elvsåshagen T, Escott-Price V, Fan CC, Fischer SB, Flickinger M, Foroud TM, Forty L, Frank J, Fraser C, Freimer NB, Frisén L, Gade K, Gage D, Garnham J, Giambartolomei C, Pedersen MG, Goldstein J, Gordon SD, Gordon-Smith K, Green EK, Green MJ, Greenwood TA, Grove J, Guan W, Guzman-Parra J, Hamshere ML, Hautzinger M, Heilbronner U, Herms S, Hipolito M, Hoffmann P, Holland D, Huckins L, Jamain S, Johnson JS, Juréus A, Kandaswamy R, Karlsson R, Kennedy JL, Kittel-Schneider S, Knowles JA, Kogevinas M, Koller AC, Kupka R, Lavebratt C, Lawrence J, Lawson WB, Leber M, Lee PH, Levy SE, Li JZ, Liu C, Lucae S, Maaser A, MacIntyre DJ, Mahon PB, Maier W, Martinsson L, McCarroll S, McGuffin P, McInnis MG, McKay JD, Medeiros H, Medland SE, Meng F, Milani L, Montgomery GW, Morris DW, Mühleisen TW, Mullins N, Nguyen H, Nievergelt CM, Adolfsson AN, Nwulia EA, O'Donovan C, Loohuis LMO, Ori APS, Oruc L, Ösby U, Perlis RH, Perry A, Pfennig A, Potash JB, Purcell SM, Regeer EJ, Reif A, Reinbold CS, Rice JP, Rivas F, Rivera M, Roussos P, Ruderfer DM, Ryu E, Sánchez-Mora C, Schatzberg AF, Scheftner WA, Schork NJ, Shannon Weickert C, Shehktman T, Shilling PD, Sigurdsson E, Slaney C, Smeland OB, Sobell JL, Søholm Hansen C, Spijker AT, St Clair D, Steffens M, Strauss JS, Streit F, Strohmaier J, Szelinger S, Thompson RC, Thorgeirsson TE, Treutlein J, Vedder H, Wang W, Watson SJ, Weickert TW, Witt SH, Xi S, Xu W, Young AH, Zandi P, Zhang P, Zöllner S, Adolfsson R, Agartz I, Alda M, Backlund L, Baune BT, Bellivier F, Berrettini WH, Biernacka JM, Blackwood DHR, Boehnke M, Børglum AD, Corvin A, Craddock N, Daly MJ, Dannlowski U, Esko T, Etain B, Frye M, Fullerton JM, Gershon ES, Gill M, Goes F, Grigoroiu-Serbanescu M, Hauser J, Hougaard DM, Hultman CM, Jones I, Jones LA, Kahn RS, Kirov G, Landén M, Leboyer M, Lewis CM, Li QS, Lissowska J, Martin NG, Mayoral F, McElroy SL, McIntosh AM, McMahon FJ, Melle I, Metspalu A, Mitchell PB, Morken G, Mors O, Mortensen PB, Müller-Myhsok B, Myers RM, Neale BM, Nimgaonkar V, Nordentoft M, Nöthen MM, O'Donovan MC, Oedegaard KJ, Owen MJ, Paciga SA, Pato C, Pato MT, Posthuma D, Ramos-Quiroga JA, Ribasés M, Rietschel M, Rouleau GA, Schalling M, Schofield PR, Schulze TG, Serretti A, Smoller JW, Stefansson H, Stefansson K, Stordal E, Sullivan PF, Turecki G, Vaaler AE, Vieta E, Vincent JB, Werge T, Nurnberger JI, Wray NR, Di Florio A, Edenberg HJ, Cichon S, Ophoff RA, Scott LJ, Andreassen OA, Kelsoe J, Sklar P
Genome-wide association study identifies 30 loci associated with bipolar disorder. Nat Genet. 2019 05; 51(5):793-803.
Genome-wide association study identifies 30 loci associated with bipolar disorder.
McCoy TH, Wiste AK, Doyle AE, Pellegrini AM, Perlis RH
Association between child psychiatric emergency room outcomes and dimensions of psychopathology. Gen Hosp Psychiatry. 2019 Jul - Aug; 59:1-6.
Association between child psychiatric emergency room outcomes and dimensions of psychopathology.
Harvard T.H. Chan School of Public Health
McNeil Family Professor of Health Care Policy
Associate Professor of Psychiatry, Part-time
Trends in Proportion of Women as Authors of Medical Journal Articles, 2008-2018. JAMA Intern Med. 2019 Sep 01; 179(9):1285-1287.
Trends in Proportion of Women as Authors of Medical Journal Articles, 2008-2018.
Biederman J, Fried R, DiSalvo M, Woodworth KY, Biederman I, Noyes E, Faraone SV, Perlis RH
A Novel Text Message Intervention to Improve Adherence to Stimulants in Adults With Attention Deficit/Hyperactivity Disorder. J Clin Psychopharmacol. 2019 Jul/Aug; 39(4):351-356.
A Novel Text Message Intervention to Improve Adherence to Stimulants in Adults With Attention Deficit/Hyperactivity Disorder.
Zhao WN, Hylton NK, Wang J, Chindavong PS, Alural B, Kurtser I, Subramanian A, Mazitschek R, Perlis RH, Haggarty SJ
Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA). Mol Cell Neurosci. 2019 09; 99:103386.
Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA).
Biederman J, Fried R, DiSalvo M, Storch B, Pulli A, Woodworth KY, Biederman I, Faraone SV, Perlis RH
Evidence of Low Adherence to Stimulant Medication Among Children and Youths With ADHD: An Electronic Health Records Study. Psychiatr Serv. 2019 10 01; 70(10):874-880.
Evidence of Low Adherence to Stimulant Medication Among Children and Youths With ADHD: An Electronic Health Records Study.
Instructor in Psychology in the Department of Psychiatry
Patient-derived Models of Synaptic Pruning in Schizophrenia
Advancing Health and Health Care Using Machine Learning: JAMA Network Open Call for Papers. JAMA Netw Open. 2018 12 07; 1(8):e187176.
Skaljic M, Patel IH, Pellegrini AM, Castro VM, Perlis RH, Gordon DD
Prevalence of Financial Considerations Documented in Primary Care Encounters as Identified by Natural Language Processing Methods. JAMA Netw Open. 2019 08 02; 2(8):e1910399.
Prevalence of Financial Considerations Documented in Primary Care Encounters as Identified by Natural Language Processing Methods.
Attention-Deficit/Hyperactivity Disorder, Hypomania, and Bipolar Disorder in Youth. JAMA Psychiatry. 2019 11 01; 76(11):1119-1121.
Attention-Deficit/Hyperactivity Disorder, Hypomania, and Bipolar Disorder in Youth.
Vuijk PJ, Martin J, Braaten EB, Genovese G, Capawana MR, O'Keefe SM, Lee BA, Lind HS, Smoller JW, Faraone SV, Perlis RH, Doyle AE
Journal of the American Academy of Child and Adolescent Psychiatry
Translating Discoveries in Attention-Deficit/Hyperactivity Disorder Genomics to an Outpatient Child and Adolescent Psychiatric Cohort. J Am Acad Child Adolesc Psychiatry. 2020 08; 59(8):964-977.
Translating Discoveries in Attention-Deficit/Hyperactivity Disorder Genomics to an Outpatient Child and Adolescent Psychiatric Cohort.
Jagtap S, Thanos JM, Fu T, Wang J, Lalonde J, Dial TO, Feiglin A, Chen J, Kohane I, Lee JT, Sheridan SD, Perlis RH
Aberrant mitochondrial function in patient-derived neural cells from CDKL5 deficiency disorder and Rett syndrome. Hum Mol Genet. 2019 11 01; 28(21):3625-3636.
Aberrant mitochondrial function in patient-derived neural cells from CDKL5 deficiency disorder and Rett syndrome.
What do patients learn about psychotropic medications on the web? A natural language processing study. J Affect Disord. 2020 01 01; 260:366-371.
What do patients learn about psychotropic medications on the web? A natural language processing study.
Barroilhet SA, Pellegrini AM, McCoy TH, Perlis RH
Characterizing DSM-5 and ICD-11 personality disorder features in psychiatric inpatients at scale using electronic health records. Psychol Med. 2020 10; 50(13):2221-2229.
Characterizing DSM-5 and ICD-11 personality disorder features in psychiatric inpatients at scale using electronic health records.
Evaluating Machine Learning Articles. JAMA. 2019 11 12; 322(18):1777-1779.
McCoy TH, Han L, Pellegrini AM, Tanzi RE, Berretta S, Perlis RH
Alzheimer's & dementia : the journal of the Alzheimer's Association
Stratifying risk for dementia onset using large-scale electronic health record data: A retrospective cohort study. Alzheimers Dement. 2020 03; 16(3):531-540.
Stratifying risk for dementia onset using large-scale electronic health record data: A retrospective cohort study.
Zimmerman AJ, Hafez AK, Amoah SK, Rodriguez BA, Dell'Orco M, Lozano E, Hartley BJ, Alural B, Lalonde J, Chander P, Webster MJ, Perlis RH, Brennand KJ, Haggarty SJ, Weick J, Perrone-Bizzozero N, Brigman JL, Mellios N
A psychiatric disease-related circular RNA controls synaptic gene expression and cognition. Mol Psychiatry. 2020 11; 25(11):2712-2727.
A psychiatric disease-related circular RNA controls synaptic gene expression and cognition.
Pradier MF, McCoy TH, Hughes M, Perlis RH, Doshi-Velez F
Predicting treatment dropout after antidepressant initiation. Transl Psychiatry. 2020 02 06; 10(1):60.
Predicting treatment dropout after antidepressant initiation.
Kathuria A, Lopez-Lengowski K, Jagtap SS, McPhie D, Perlis RH, Cohen BM, Karmacharya R
Transcriptomic Landscape and Functional Characterization of Induced Pluripotent Stem Cell-Derived Cerebral Organoids in Schizophrenia. JAMA Psychiatry. 2020 07 01; 77(7):745-754.
Transcriptomic Landscape and Functional Characterization of Induced Pluripotent Stem Cell-Derived Cerebral Organoids in Schizophrenia.
Exercising Heart and Head in Managing Coronavirus Disease 2019 in Wuhan. JAMA Netw Open. 2020 03 02; 3(3):e204006.
Exercising Heart and Head in Managing Coronavirus Disease 2019 in Wuhan.
Cai N, Revez JA, Adams MJ, Andlauer TFM, Breen G, Byrne EM, Clarke TK, Forstner AJ, Grabe HJ, Hamilton SP, Levinson DF, Lewis CM, Lewis G, Martin NG, Milaneschi Y, Mors O, Müller-Myhsok B, Penninx BWJH, Perlis RH, Pistis G, Potash JB, Preisig M, Shi J, Smoller JW, Streit F, Tiemeier H, Uher R, Van der Auwera S, Viktorin A, Weissman MM, Kendler KS, Flint J
Minimal phenotyping yields genome-wide association signals of low specificity for major depression. Nat Genet. 2020 04; 52(4):437-447.
Minimal phenotyping yields genome-wide association signals of low specificity for major depression.
Sonabend W A, Pellegrini AM, Chan S, Brown HE, Rosenquist JN, Vuijk PJ, Doyle AE, Perlis RH, Cai T
Integrating questionnaire measures for transdiagnostic psychiatric phenotyping using word2vec. PLoS One. 2020; 15(4):e0230663.
Integrating questionnaire measures for transdiagnostic psychiatric phenotyping using word2vec.
Barroilhet SA, Bieling AE, McCoy TH, Perlis RH
Association between DSM-5 and ICD-11 personality dimensional traits in a general medical cohort and readmission and mortality. Gen Hosp Psychiatry. 2020 May - Jun; 64:63-67.
Association between DSM-5 and ICD-11 personality dimensional traits in a general medical cohort and readmission and mortality.
128 Factors Associated with Cost Savings Following Use of a Pharmacogenetic Assay in Individuals with Mood and Anxiety Disorders. CNS Spectr. 2020 Apr; 25(2):281-282.
128 Factors Associated with Cost Savings Following Use of a Pharmacogenetic Assay in Individuals with Mood and Anxiety Disorders.
Perlis RH, Dowd D, Fava M, Lencz T, Krause DS
Randomized, controlled, participant- and rater-blind trial of pharmacogenomic test-guided treatment versus treatment as usual for major depressive disorder. Depress Anxiety. 2020 09; 37(9):834-841.
Randomized, controlled, participant- and rater-blind trial of pharmacogenomic test-guided treatment versus treatment as usual for major depressive disorder.
Hughes MC, Pradier MF, Ross AS, McCoy TH, Perlis RH, Doshi-Velez F
Assessment of a Prediction Model for Antidepressant Treatment Stability Using Supervised Topic Models. JAMA Netw Open. 2020 05 01; 3(5):e205308.
Assessment of a Prediction Model for Antidepressant Treatment Stability Using Supervised Topic Models.
Yu JZ, Wang J, Sheridan SD, Perlis RH, Rasenick MM
N-3 polyunsaturated fatty acids promote astrocyte differentiation and neurotrophin production independent of cAMP in patient-derived neural stem cells. Mol Psychiatry. 2021 09; 26(9):4605-4615.
N-3 polyunsaturated fatty acids promote astrocyte differentiation and neurotrophin production independent of cAMP in patient-derived neural stem cells.
Electronic Health Record Documentation of Psychiatric Assessments in Massachusetts Emergency Department and Outpatient Settings During the Coronavirus Disease 2019 (COVID-19) Pandemic. JAMA Netw Open. 2020 06 01; 3(6):e2011346.
Electronic Health Record Documentation of Psychiatric Assessments in Massachusetts Emergency Department and Outpatient Settings During the Coronavirus Disease 2019 (COVID-19) Pandemic.
Biederman J, Fried R, DiSalvo M, Woodworth KY, Biederman I, Driscoll H, Noyes E, Faraone SV, Perlis RH
Further evidence of low adherence to stimulant treatment in adult ADHD: an electronic medical record study examining timely renewal of a stimulant prescription. Psychopharmacology (Berl). 2020 Sep; 237(9):2835-2843.
Further evidence of low adherence to stimulant treatment in adult ADHD: an electronic medical record study examining timely renewal of a stimulant prescription.
Hart KL, Boitano LT, Tanious A, Conrad MF, Eagleton MJ, Lillemoe KD, Perlis RH, Srivastava SD
Trends in Female Authorship in High Impact Surgical Journals Between 2008 and 2018. Ann Surg. 2022 01 01; 275(1):e115-e123.
Trends in Female Authorship in High Impact Surgical Journals Between 2008 and 2018.
Advances toward precision medicine for bipolar disorder: mechanisms & molecules. Mol Psychiatry. 2021 01; 26(1):168-185.
Advances toward precision medicine for bipolar disorder: mechanisms & molecules.
Tseng CJ, Gilbert TM, Catanese MC, Hightower BG, Peters AT, Parmar AJ, Kim M, Wang C, Roffman JL, Brown HE, Perlis RH, Zürcher NR, Hooker JM
In vivo human brain expression of histone deacetylases in bipolar disorder. Transl Psychiatry. 2020 07 08; 10(1):224.
In vivo human brain expression of histone deacetylases in bipolar disorder.
Differences among Research Domain Criteria score trajectories by Diagnostic and Statistical Manual categorical diagnosis during inpatient hospitalization. PLoS One. 2020; 15(8):e0237698.
Differences among Research Domain Criteria score trajectories by Diagnostic and Statistical Manual categorical diagnosis during inpatient hospitalization.
medRxiv : the preprint server for health sciences
Laboratory findings associated with severe illness and mortality among hospitalized individuals with coronavirus disease 2019 in Eastern Massachusetts. medRxiv. 2020 Aug 28.
Laboratory findings associated with severe illness and mortality among hospitalized individuals with coronavirus disease 2019 in Eastern Massachusetts.
Pradier MF, Hughes MC, McCoy TH, Barroilhet SA, Doshi-Velez F, Perlis RH
Predicting change in diagnosis from major depression to bipolar disorder after antidepressant initiation. Neuropsychopharmacology. 2021 01; 46(2):455-461.
Predicting change in diagnosis from major depression to bipolar disorder after antidepressant initiation.
Sheridan SD, Thanos JM, De Guzman RM, McCrea LT, Horng J, Fu T, Sellgren CM, Perlis RH, Edlow AG
bioRxiv : the preprint server for biology
Umbilical cord blood derived microglia-like cells to model COVID-19 exposure. bioRxiv. 2020 Oct 07.
Umbilical cord blood derived microglia-like cells to model COVID-19 exposure.
Hard Truths About Suicide Prevention. JAMA Netw Open. 2020 10 01; 3(10):e2022713.
Gordon D, Ford A, Triedman N, Hart K, Perlis R
Health Care Consumer Shopping Behaviors and Sentiment: Qualitative Study. J Particip Med. 2020 Jun 16; 12(2):e13924.
Health Care Consumer Shopping Behaviors and Sentiment: Qualitative Study.
Laboratory Findings Associated With Severe Illness and Mortality Among Hospitalized Individuals With Coronavirus Disease 2019 in Eastern Massachusetts. JAMA Netw Open. 2020 10 01; 3(10):e2023934.
Laboratory Findings Associated With Severe Illness and Mortality Among Hospitalized Individuals With Coronavirus Disease 2019 in Eastern Massachusetts.
Essential Work: Psychiatric Clinical Investigation in the Midst of a Pandemic. Am J Psychiatry. 2020 12 01; 177(12):1117-1118.
Essential Work: Psychiatric Clinical Investigation in the Midst of a Pandemic.
Hart KL, Pellegrini AM, Forester BP, Berretta S, Murphy SN, Perlis RH, McCoy TH
Distribution of agitation and related symptoms among hospitalized patients using a scalable natural language processing method. Gen Hosp Psychiatry. 2021 Jan-Feb; 68:46-51.
Distribution of agitation and related symptoms among hospitalized patients using a scalable natural language processing method.
Authorship inequality: a bibliometric study of the concentration of authorship among a diminishing number of individuals in high-impact medical journals, 2008-2019. BMJ Open. 2021 01 06; 11(1):e046002.
Authorship inequality: a bibliometric study of the concentration of authorship among a diminishing number of individuals in high-impact medical journals, 2008-2019.
Clapp MA, McCoy TH, James KE, Kaimal AJ, Perlis RH
American journal of obstetrics & gynecology MFM
The utility of electronic health record data for identifying postpartum hemorrhage. Am J Obstet Gynecol MFM. 2021 03; 3(2):100305.
The utility of electronic health record data for identifying postpartum hemorrhage.
Boag W, Kovaleva O, McCoy TH, Rumshisky A, Szolovits P, Perlis RH
Hard for humans, hard for machines: predicting readmission after psychiatric hospitalization using narrative notes. Transl Psychiatry. 2021 01 11; 11(1):32.
Hard for humans, hard for machines: predicting readmission after psychiatric hospitalization using narrative notes.
Perlis RH, Haneuse SJPA, Rubenfeld GD, Fihn SD, Rivara FP
Reporting Clinical Studies Affected by the COVID-19 Pandemic: Guidelines for Authors. JAMA Netw Open. 2021 01 04; 4(1):e2036155.
Reporting Clinical Studies Affected by the COVID-19 Pandemic: Guidelines for Authors.
Jacobs M, Pradier MF, McCoy TH, Perlis RH, Doshi-Velez F, Gajos KZ
How machine-learning recommendations influence clinician treatment selections: the example of the antidepressant selection. Transl Psychiatry. 2021 02 04; 11(1):108.
How machine-learning recommendations influence clinician treatment selections: the example of the antidepressant selection.
Jaywant A, Vanderlind WM, Alexopoulos GS, Fridman CB, Perlis RH, Gunning FM
Frequency and profile of objective cognitive deficits in hospitalized patients recovering from COVID-19. Neuropsychopharmacology. 2021 12; 46(13):2235-2240.
Frequency and profile of objective cognitive deficits in hospitalized patients recovering from COVID-19.
Consistency of performance of adverse outcome prediction models for hospitalized COVID-19 patients. medRxiv. 2021 Mar 01.
Consistency of performance of adverse outcome prediction models for hospitalized COVID-19 patients.
Perlis RH, Ognyanova K, Santillana M, Baum MA, Lazer D, Druckman J, Della Volpe J
Association of Acute Symptoms of COVID-19 and Symptoms of Depression in Adults. JAMA Netw Open. 2021 03 01; 4(3):e213223.
Association of Acute Symptoms of COVID-19 and Symptoms of Depression in Adults.
Castro VM, Sacks CA, Perlis RH, McCoy TH
Journal of the Academy of Consultation-Liaison Psychiatry
Development and External Validation of a Delirium Prediction Model for Hospitalized Patients With Coronavirus Disease 2019. J Acad Consult Liaison Psychiatry. 2021 May-Jun; 62(3):298-308.
Development and External Validation of a Delirium Prediction Model for Hospitalized Patients With Coronavirus Disease 2019.
Sheridan SD, Thanos JM, De Guzman RM, McCrea LT, Horng JE, Fu T, Sellgren CM, Perlis RH, Edlow AG
Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure. Transl Psychiatry. 2021 03 19; 11(1):179.
Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure.
Garvert L, Baune BT, Berger K, Boomsma DI, Breen G, Greinacher A, Hamilton SP, Levinson DF, Lewis CM, Lucae S, Magnusson PKE, Martin NG, McIntosh AM, Mors O, Müller-Myhsok B, Penninx BWJH, Perlis RH, Pistis G, Potash JB, Preisig M, Rietschel M, Shi J, Smoller JW, Tiemeier H, Uher R, Völker U, Völzke H, Weissman MM, Grabe HJ, Van der Auwera S
The association between genetically determined ABO blood types and major depressive disorder. Psychiatry Res. 2021 05; 299:113837.
The association between genetically determined ABO blood types and major depressive disorder.
Perlis RH, Santillana M, Ognyanova K, Green J, Druckman J, Lazer D, Baum MA
Comparison of post-COVID depression and major depressive disorder. medRxiv. 2021 Apr 04.
Comparison of post-COVID depression and major depressive disorder.
Castro VM, Gunning FM, McCoy TH, Perlis RH
Mood Disorders and Outcomes of COVID-19 Hospitalizations. Am J Psychiatry. 2021 06; 178(6):541-547.
Mood Disorders and Outcomes of COVID-19 Hospitalizations.
Data-driven subtyping in major depressive disorder
Clapp MA, James KE, McCoy TH, Perlis RH, Kaimal AJ
American journal of obstetrics and gynecology
The use of a validated obstetrical risk score for maternal morbidity to predict postpartum hemorrhage for women in labor. Am J Obstet Gynecol. 2021 08; 225(2):199-200.
The use of a validated obstetrical risk score for maternal morbidity to predict postpartum hemorrhage for women in labor.
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Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nat Genet. 2021 06; 53(6):817-829.
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.
Morley TJ, Han L, Castro VM, Morra J, Perlis RH, Cox NJ, Bastarache L, Ruderfer DM
Phenotypic signatures in clinical data enable systematic identification of patients for genetic testing. Nat Med. 2021 06; 27(6):1097-1104.
Phenotypic signatures in clinical data enable systematic identification of patients for genetic testing.
Blokland GAM, Grove J, Chen CY, Cotsapas C, Tobet S, Handa R, St Clair D, Lencz T, Mowry BJ, Periyasamy S, Cairns MJ, Tooney PA, Wu JQ, Kelly B, Kirov G, Sullivan PF, Corvin A, Riley BP, Esko T, Milani L, Jönsson EG, Palotie A, Ehrenreich H, Begemann M, Steixner-Kumar A, Sham PC, Iwata N, Weinberger DR, Gejman PV, Sanders AR, Buxbaum JD, Rujescu D, Giegling I, Konte B, Hartmann AM, Bramon E, Murray RM, Pato MT, Lee J, Melle I, Molden E, Ophoff RA, McQuillin A, Bass NJ, Adolfsson R, Malhotra AK, Martin NG, Fullerton JM, Mitchell PB, Schofield PR, Forstner AJ, Degenhardt F, Schaupp S, Comes AL, Kogevinas M, Guzman-Parra J, Reif A, Streit F, Sirignano L, Cichon S, Grigoroiu-Serbanescu M, Hauser J, Lissowska J, Mayoral F, Müller-Myhsok B, Swiatkowska B, Schulze TG, Nöthen MM, Rietschel M, Kelsoe J, Leboyer M, Jamain S, Etain B, Bellivier F, Vincent JB, Alda M, O'Donovan C, Cervantes P, Biernacka JM, Frye M, McElroy SL, Scott LJ, Stahl EA, Landén M, Hamshere ML, Smeland OB, Djurovic S, Vaaler AE, Andreassen OA, Baune BT, Air T, Preisig M, Uher R, Levinson DF, Weissman MM, Potash JB, Shi J, Knowles JA, Perlis RH, Lucae S, Boomsma DI, Penninx BWJH, Hottenga JJ, de Geus EJC, Willemsen G, Milaneschi Y, Tiemeier H, Grabe HJ, Teumer A, Van der Auwera S, Völker U, Hamilton SP, Magnusson PKE, Viktorin A, Mehta D, Mullins N, Adams MJ, Breen G, McIntosh AM, Lewis CM, Hougaard DM, Nordentoft M, Mors O, Mortensen PB, Werge T, Als TD, Børglum AD, Petryshen TL, Smoller JW, Goldstein JM
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders. Biol Psychiatry. 2022 01 01; 91(1):102-117.
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.
Factors Associated With Self-reported Symptoms of Depression Among Adults With and Without a Previous COVID-19 Diagnosis. JAMA Netw Open. 2021 06 01; 4(6):e2116612.
Factors Associated With Self-reported Symptoms of Depression Among Adults With and Without a Previous COVID-19 Diagnosis.
Rivara FP, Bradley SM, Catenacci DV, Desai AN, Ganguli I, Haneuse SJPA, Inouye SK, Jacobs EA, Kan K, Kim HS, Morris AM, Ogedegbe O, Perencevich EN, Perlis RH, Powell E, Rubenfeld GD, Shulman LN, Trueger NS, Fihn SD
Structural Racism and JAMA Network Open. JAMA Netw Open. 2021 06 01; 4(6):e2120269.
Structural Racism and JAMA Network Open.
Stratified delirium risk using prescription medication data in a state-wide cohort. Gen Hosp Psychiatry. 2021 Jul-Aug; 71:114-120.
Stratified delirium risk using prescription medication data in a state-wide cohort.
Mapping of Transdiagnostic Neuropsychiatric Phenotypes Across Patients in Two General Hospitals. J Acad Consult Liaison Psychiatry. 2021 Jul-Aug; 62(4):430-439.
Mapping of Transdiagnostic Neuropsychiatric Phenotypes Across Patients in Two General Hospitals.
Castro VM, Rosand J, Giacino JT, McCoy TH, Perlis RH
Case-control study of neuropsychiatric symptoms following COVID-19 hospitalization in 2 academic health systems. medRxiv. 2021 Jul 14.
Case-control study of neuropsychiatric symptoms following COVID-19 hospitalization in 2 academic health systems.
Assessment of the Performance Consistency of an Adverse Outcome Prediction Tool for Patients Hospitalized With COVID-19. JAMA Netw Open. 2021 07 01; 4(7):e2118413.
Assessment of the Performance Consistency of an Adverse Outcome Prediction Tool for Patients Hospitalized With COVID-19.
Perlis RH, Ognyanova K, Quintana A, Green J, Santillana M, Lin J, Druckman J, Lazer D, Simonson MD, Baum MA, Chwe H
Gender-specificity of resilience in major depressive disorder. Depress Anxiety. 2021 10; 38(10):1026-1033.
Gender-specificity of resilience in major depressive disorder.
Pradier MF, Zazo J, Parbhoo S, Perlis RH, Zazzi M, Doshi-Velez F
AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science
Preferential Mixture-of-Experts: Interpretable Models that Rely on Human Expertise As Much As Possible. AMIA Jt Summits Transl Sci Proc. 2021; 2021:525-534.
Preferential Mixture-of-Experts: Interpretable Models that Rely on Human Expertise As Much As Possible.
The value of intrapartum factors in predicting maternal morbidity. Am J Obstet Gynecol MFM. 2022 01; 4(1):100485.
The value of intrapartum factors in predicting maternal morbidity.
Tilak M, Alural B, Wismer SE, Brasher MI, New LA, Sheridan SD, Perlis RH, Coppolino MG, Lalonde J, Jones N
Adaptor Protein ShcD/SHC4 Interacts with Tie2 Receptor to Synergistically Promote Glioma Cell Invasion. Mol Cancer Res. 2021 05; 19(5):757-770.
Adaptor Protein ShcD/SHC4 Interacts with Tie2 Receptor to Synergistically Promote Glioma Cell Invasion.
Miles AE, Dos Santos FC, Byrne EM, Renteria ME, McIntosh AM, Adams MJ, Pistis G, Castelao E, Preisig M, Baune BT, Schubert KO, Lewis CM, Jones LA, Jones I, Uher R, Smoller JW, Perlis RH, Levinson DF, Potash JB, Weissman MM, Shi J, Lewis G, Penninx BWJH, Boomsma DI, Hamilton SP, Sibille E, Hariri AR, Nikolova YS
Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk. Neuropsychopharmacology. 2021 12; 46(13):2304-2311.
Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk.
Perlis RH, Green J, Simonson M, Ognyanova K, Santillana M, Lin J, Quintana A, Chwe H, Druckman J, Lazer D, Baum MA, Della Volpe J
Association Between Social Media Use and Self-reported Symptoms of Depression in US Adults. JAMA Netw Open. 2021 11 01; 4(11):e2136113.
Association Between Social Media Use and Self-reported Symptoms of Depression in US Adults.
DeTore NR, Sylvia L, Park ER, Burke A, Levison JH, Shannon A, Choi KW, Jain FA, Coman DC, Herman J, Perlis R, Fava M, Holt DJ
Promoting resilience in healthcare workers during the COVID-19 pandemic with a brief online intervention. J Psychiatr Res. 2022 02; 146:228-233.
Promoting resilience in healthcare workers during the COVID-19 pandemic with a brief online intervention.
Castro VM, Hart KL, Sacks CA, Murphy SN, Perlis RH, McCoy TH
Longitudinal validation of an electronic health record delirium prediction model applied at admission in COVID-19 patients. Gen Hosp Psychiatry. 2022 Jan-Feb; 74:9-17.
Longitudinal validation of an electronic health record delirium prediction model applied at admission in COVID-19 patients.
Hafez AK, Zimmerman AJ, Papageorgiou G, Chandrasekaran J, Amoah SK, Lin R, Lozano E, Pierotti C, Dell'Orco M, Hartley BJ, Alural B, Lalonde J, Esposito JM, Berretta S, Squassina A, Chillotti C, Voloudakis G, Shao Z, Fullard JF, Brennand KJ, Turecki G, Roussos P, Perlis RH, Haggarty SJ, Perrone-Bizzozero N, Brigman JL, Mellios N
A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning. Cell Rep. 2022 01 18; 38(3):110282.
A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning.
Vidal-Ribas P, Govender T, Sundaram R, Perlis RH, Gilman SE
Prenatal origins of suicide mortality: A prospective cohort study in the United States. Transl Psychiatry. 2022 01 10; 12(1):14.
Prenatal origins of suicide mortality: A prospective cohort study in the United States.
Perlis RH, Ognyanova K, Santillana M, Lin J, Druckman J, Lazer D, Green J, Simonson M, Baum MA, Della Volpe J
Association of Major Depressive Symptoms With Endorsement of COVID-19 Vaccine Misinformation Among US Adults. JAMA Netw Open. 2022 01 04; 5(1):e2145697.
Association of Major Depressive Symptoms With Endorsement of COVID-19 Vaccine Misinformation Among US Adults.
Pellegrini AM, Huang EJ, Staples PC, Hart KL, Lorme JM, Brown HE, Perlis RH, Onnela JJ
Estimating longitudinal depressive symptoms from smartphone data in a transdiagnostic cohort. Brain Behav. 2022 02; 12(2):e02077.
Estimating longitudinal depressive symptoms from smartphone data in a transdiagnostic cohort.
Is It Time to Try Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Again? JAMA Psychiatry. 2022 04 01; 79(4):281-282.
Is It Time to Try Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Again?
Lee PH, Doyle AE, Li X, Silberstein M, Jung JY, Gollub RL, Nierenberg AA, Liu RT, Kessler RC, Perlis RH, Fava M
Genetic Association of Attention-Deficit/Hyperactivity Disorder and Major Depression With Suicidal Ideation and Attempts in Children: The Adolescent Brain Cognitive Development Study. Biol Psychiatry. 2022 08 01; 92(3):236-245.
Genetic Association of Attention-Deficit/Hyperactivity Disorder and Major Depression With Suicidal Ideation and Attempts in Children: The Adolescent Brain Cognitive Development Study.
Patient-Derived In Vitro Models of Microglial Function and Synaptic Engulfment in Schizophrenia. Biol Psychiatry. 2022 09 15; 92(6):470-479.
Patient-Derived In Vitro Models of Microglial Function and Synaptic Engulfment in Schizophrenia.
Shook LL, Sullivan EL, Lo JO, Perlis RH, Edlow AG
COVID-19 in pregnancy: implications for fetal brain development. Trends Mol Med. 2022 04; 28(4):319-330.
COVID-19 in pregnancy: implications for fetal brain development.
Perlis RH, Simonson MD, Green J, Lin J, Safarpour A, Lunz Trujillo K, Quintana A, Chwe H, Della Volpe J, Ognyanova K, Santillana M, Druckman J, Lazer D, Baum MA
Prevalence of Firearm Ownership Among Individuals With Major Depressive Symptoms. JAMA Netw Open. 2022 03 01; 5(3):e223245.
Prevalence of Firearm Ownership Among Individuals With Major Depressive Symptoms.
Lage I, McCoy TH, Perlis RH, Doshi-Velez F
Efficiently identifying individuals at high risk for treatment resistance in major depressive disorder using electronic health records. J Affect Disord. 2022 06 01; 306:254-259.
Efficiently identifying individuals at high risk for treatment resistance in major depressive disorder using electronic health records.
Lage I, Pradier MF, McCoy TH, Perlis RH, Doshi-Velez F
Do clinicians follow heuristics in prescribing antidepressants? J Affect Disord. 2022 08 15; 311:110-114.
Do clinicians follow heuristics in prescribing antidepressants?
Clapp MA, Kim E, James KE, Perlis RH, Kaimal AJ, McCoy TH
Natural language processing of admission notes to predict severe maternal morbidity during the delivery encounter. Am J Obstet Gynecol. 2022 09; 227(3):511.e1-511.e8.
Natural language processing of admission notes to predict severe maternal morbidity during the delivery encounter.
Lee PH, Doyle AE, Silberstein M, Jung JY, Liu RT, Perlis RH, Roffman J, Smoller JW, Fava M, Kessler RC
Associations Between Genetic Risk for Adult Suicide Attempt and Suicidal Behaviors in Young Children in the US. JAMA Psychiatry. 2022 Oct 01; 79(10):971-980.
Associations Between Genetic Risk for Adult Suicide Attempt and Suicidal Behaviors in Young Children in the US.
Mending the Holes in the Suicide Safety Net. JAMA Netw Open. 2022 07 01; 5(7):e2225794.
Mending the Holes in the Suicide Safety Net.
Edlow AG, Castro VM, Shook LL, Kaimal AJ, Perlis RH
Neurodevelopmental Outcomes at 1 Year in Infants of Mothers Who Tested Positive for SARS-CoV-2 During Pregnancy. JAMA Netw Open. 2022 06 01; 5(6):e2215787.
Neurodevelopmental Outcomes at 1 Year in Infants of Mothers Who Tested Positive for SARS-CoV-2 During Pregnancy.
Nehme R, Pietiläinen O, Artomov M, Tegtmeyer M, Valakh V, Lehtonen L, Bell C, Singh T, Trehan A, Sherwood J, Manning D, Peirent E, Malik R, Guss EJ, Hawes D, Beccard A, Bara AM, Hazelbaker DZ, Zuccaro E, Genovese G, Loboda AA, Neumann A, Lilliehook C, Kuismin O, Hamalainen E, Kurki M, Hultman CM, Kähler AK, Paulo JA, Ganna A, Madison J, Cohen B, McPhie D, Adolfsson R, Perlis R, Dolmetsch R, Farhi S, McCarroll S, Hyman S, Neale B, Barrett LE, Harper W, Palotie A, Daly M, Eggan K
The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia. Nat Commun. 2022 06 27; 13(1):3690.
The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia.
Parmentier T, James FMK, Hewitson E, Bailey C, Werry N, Sheridan SD, Perlis RH, Perreault ML, Gaitero L, Lalonde J, LaMarre J
Human cerebral spheroids undergo 4-aminopyridine-induced, activity associated changes in cellular composition and microrna expression. Sci Rep. 2022 06 01; 12(1):9143.
Human cerebral spheroids undergo 4-aminopyridine-induced, activity associated changes in cellular composition and microrna expression.
Case-control study of neuropsychiatric symptoms in electronic health records following COVID-19 hospitalization in 2 academic health systems. Mol Psychiatry. 2022 09; 27(9):3898-3903.
Case-control study of neuropsychiatric symptoms in electronic health records following COVID-19 hospitalization in 2 academic health systems.
Tai DJC, Razaz P, Erdin S, Gao D, Wang J, Nuttle X, de Esch CE, Collins RL, Currall BB, O'Keefe K, Burt ND, Yadav R, Wang L, Mohajeri K, Aneichyk T, Ragavendran A, Stortchevoi A, Morini E, Ma W, Lucente D, Hastie A, Kelleher RJ, Perlis RH, Talkowski ME, Gusella JF
Tissue- and cell-type-specific molecular and functional signatures of 16p11.2 reciprocal genomic disorder across mouse brain and human neuronal models. Am J Hum Genet. 2022 10 06; 109(10):1789-1813.
Tissue- and cell-type-specific molecular and functional signatures of 16p11.2 reciprocal genomic disorder across mouse brain and human neuronal models.
Oliveira AO, Malwade S, Rufino de Sousa N, Goparaju SK, Gracias J, Orhan F, Steponaviciute L, Schalling M, Sheridan SD, Perlis RH, Rothfuchs AG, Sellgren CM
SARS-CoV-2 promotes microglial synapse elimination in human brain organoids. Mol Psychiatry. 2022 10; 27(10):3939-3950.
SARS-CoV-2 promotes microglial synapse elimination in human brain organoids.
Gracias J, Orhan F, Hörbeck E, Holmén-Larsson J, Khanlarkani N, Malwade S, Goparaju SK, Schwieler L, Demirel IS, Fu T, Fatourus-Bergman H, Pelanis A, Goold CP, Goulding A, Annerbrink K, Isgren A, Sparding T, Schalling M, Yañez VAC, Göpfert JC, Nilsson J, Brinkmalm A, Blennow K, Zetterberg H, Engberg G, Piehl F, Sheridan SD, Perlis RH, Cervenka S, Erhardt S, Landen M, Sellgren CM
Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia. Nat Commun. 2022 11 03; 13(1):6427.
Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia.
Clapp MA, Kim E, James KE, Perlis RH, Kaimal AJ, McCoy TH, Easter SR
Comparison of Natural Language Processing of Clinical Notes With a Validated Risk-Stratification Tool to Predict Severe Maternal Morbidity. JAMA Netw Open. 2022 10 03; 5(10):e2234924.
Comparison of Natural Language Processing of Clinical Notes With a Validated Risk-Stratification Tool to Predict Severe Maternal Morbidity.
Perlis RH, Santillana M, Ognyanova K, Safarpour A, Lunz Trujillo K, Simonson MD, Green J, Quintana A, Druckman J, Baum MA, Lazer D
Prevalence and Correlates of Long COVID Symptoms Among US Adults. JAMA Netw Open. 2022 10 03; 5(10):e2238804.
Prevalence and Correlates of Long COVID Symptoms Among US Adults.
Edlow AG, Castro VM, Shook LL, Haneuse S, Kaimal AJ, Perlis RH
Sex-specific neurodevelopmental outcomes in offspring of mothers with SARS-CoV-2 in pregnancy: an electronic health records cohort. medRxiv. 2022 Nov 18.
Sex-specific neurodevelopmental outcomes in offspring of mothers with SARS-CoV-2 in pregnancy: an electronic health records cohort.
Perlis RH, Trujillo KL, Safarpour A, Santillana M, Ognyanova K, Druckman J, Lazer D
Research Letter: Association between long COVID symptoms and employment status. medRxiv. 2022 Nov 18.
Research Letter: Association between long COVID symptoms and employment status.
Clapp MA, James KE, Mccoy TH, Perlis RH, Kaimal AJ
The Application of a Standard Risk Threshold for the Stratification of Maternal Morbidity among Population Subgroups. Am J Perinatol. 2024 05; 41(S 01):e1235-e1240.
The Application of a Standard Risk Threshold for the Stratification of Maternal Morbidity among Population Subgroups.
Rapino F, Natoli T, Limone F, O'Connor E, Blank J, Tegtmeyer M, Chen W, Norabuena E, Narula J, Hazelbaker D, Angelini G, Barrett L, O'Neil A, Beattie UK, Thanos JM, de Rivera H, Sheridan SD, Perlis RH, McCarroll SA, Stevens B, Subramanian A, Nehme R, Rubin LL
Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes. Stem Cell Reports. 2023 01 10; 18(1):237-253.
Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes.
Szmulewicz AG, Wanis KN, Perlis RH, Hernández-Díaz S, Öngür D, Hernán MA
Emulating a Target Trial of Dynamic Treatment Strategies for Major Depressive Disorder Using Data From the STAR*D Randomized Trial. Biol Psychiatry. 2023 06 15; 93(12):1127-1136.
Emulating a Target Trial of Dynamic Treatment Strategies for Major Depressive Disorder Using Data From the STAR*D Randomized Trial.
Perlis RH, Kendall-Taylor J, Hart K, Ganguli I, Berlin JA, Bradley SM, Haneuse S, Inouye SK, Jacobs EA, Morris A, Ogedegbe O, Perencevich E, Shulman LN, Trueger NS, Fihn SD, Rivara FP, Flanagin A
Peer Review in a General Medical Research Journal Before and During the COVID-19 Pandemic. JAMA Netw Open. 2023 01 03; 6(1):e2253296.
Peer Review in a General Medical Research Journal Before and During the COVID-19 Pandemic.
Perlis RH, Santillana M, Ognyanova K, Lazer D
Correlates of symptomatic remission among individuals with post-COVID-19 condition. medRxiv. 2023 Feb 01.
Correlates of symptomatic remission among individuals with post-COVID-19 condition.
Perlis RH, Lunz Trujillo K, Safarpour A, Santillana M, Ognyanova K, Druckman J, Lazer D
Association of Post-COVID-19 Condition Symptoms and Employment Status. JAMA Netw Open. 2023 02 01; 6(2):e2256152.
Association of Post-COVID-19 Condition Symptoms and Employment Status.
Kim YR, Lauze MS, Slattery M, Perlis RH, Holsen LM, Breithaupt L, Stern CM, Fava M, Thomas JJ, Lawson EA, Misra M, Eddy KT
Association Between Ghrelin and Body Weight Trajectory in Individuals With Anorexia Nervosa. JAMA Netw Open. 2023 03 01; 6(3):e234625.
Association Between Ghrelin and Body Weight Trajectory in Individuals With Anorexia Nervosa.
Sex-Specific Neurodevelopmental Outcomes Among Offspring of Mothers With SARS-CoV-2 Infection During Pregnancy. JAMA Netw Open. 2023 03 01; 6(3):e234415.
Sex-Specific Neurodevelopmental Outcomes Among Offspring of Mothers With SARS-CoV-2 Infection During Pregnancy.
Vidal-Ribas P, Govender T, Yu J, Sundaram R, Perlis RH, Gilman SE
Journal of child psychology and psychiatry, and allied disciplines
Children's cognitive performance and suicide risk through middle adulthood. J Child Psychol Psychiatry. 2023 10; 64(10):1480-1491.
Children's cognitive performance and suicide risk through middle adulthood.
Hewitt T, Alural B, Tilak M, Wang J, Becke N, Chartley E, Perreault M, Haggarty SJ, Sheridan SD, Perlis RH, Jones N, Mellios N, Lalonde J
Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca2+ entry and accelerated differentiation. Mol Psychiatry. 2023 12; 28(12):5237-5250.
Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca2+ entry and accelerated differentiation.
Green J, Druckman JN, Baum MA, Ognyanova K, Simonson MD, Perlis RH, Lazer D
Media use and vaccine resistance. PNAS Nexus. 2023 May; 2(5):pgad146.
Suicidality Screening Guidelines Highlight the Need for Intervention Studies. JAMA Netw Open. 2023 06 01; 6(6):e2318773.
Suicidality Screening Guidelines Highlight the Need for Intervention Studies.
Research Letter: Application of GPT-4 to select next-step antidepressant treatment in major depression. medRxiv. 2023 Apr 18.
Research Letter: Application of GPT-4 to select next-step antidepressant treatment in major depression.
Solomonov N, Green J, Quintana A, Lin J, Ognyanova K, Santillana M, Druckman JN, Baum MA, Lazer D, Gunning FM, Perlis RH
A 50-state survey study of thoughts of suicide and social isolation among older adults in the United States. J Affect Disord. 2023 08 01; 334:43-49.
A 50-state survey study of thoughts of suicide and social isolation among older adults in the United States.
Classifying Firearm Injury Using EHR Data-Finding the Phenotype by Reading the Notes. JAMA Netw Open. 2023 04 03; 6(4):e235781.
Classifying Firearm Injury Using EHR Data-Finding the Phenotype by Reading the Notes.
Sheridan SD, Horng JE, Yeh H, McCrea L, Wang J, Fu T, Perlis RH
Loss of Function in the Neurodevelopmental Disease and Schizophrenia-Associated Gene CYFIP1 in Human Microglia-like Cells Supports a Functional Role in Synaptic Engulfment. Biol Psychiatry. 2024 Apr 01; 95(7):676-686.
Loss of Function in the Neurodevelopmental Disease and Schizophrenia-Associated Gene CYFIP1 in Human Microglia-like Cells Supports a Functional Role in Synaptic Engulfment.
Perlis RH, Lunz Trujillo K, Green J, Safarpour A, Druckman JN, Santillana M, Ognyanova K, Lazer D
Misinformation, Trust, and Use of Ivermectin and Hydroxychloroquine for COVID-19. JAMA Health Forum. 2023 09 01; 4(9):e233257.
Misinformation, Trust, and Use of Ivermectin and Hydroxychloroquine for COVID-19.
Perlis RH, Lunz Trujillo K, Safarpour A, Quintana A, Simonson MD, Perlis J, Santillana M, Ognyanova K, Baum MA, Druckman JN, Lazer D
Community Mobility and Depressive Symptoms During the COVID-19 Pandemic in the United States. JAMA Netw Open. 2023 09 05; 6(9):e2334945.
Community Mobility and Depressive Symptoms During the COVID-19 Pandemic in the United States.
Shook LL, James KE, Roberts DJ, Powe CE, Perlis RH, Thornburg KL, O'Tierney-Ginn PF, Edlow AG
Sex-specific impact of maternal obesity on fetal placental macrophages and cord blood triglycerides. Placenta. 2023 09 07; 140:100-108.
Sex-specific impact of maternal obesity on fetal placental macrophages and cord blood triglycerides.
Evaluating the Application of Large Language Models in Clinical Research Contexts. JAMA Netw Open. 2023 10 02; 6(10):e2335924.
Evaluating the Application of Large Language Models in Clinical Research Contexts.
Meyer K, Ling KH, Yeo PL, Spathopoulou A, Drake D, Choi J, Aron L, Garcia-Corral M, Ko T, Lee EA, Tam JM, Perlis RH, Church GM, Tsai LH, Yankner BA
Impaired neural stress resistance and loss of REST in bipolar disorder. Mol Psychiatry. 2024 01; 29(1):153-164.
Impaired neural stress resistance and loss of REST in bipolar disorder.
Characterization of schizophrenia liability genes in models of human microglial synaptic pruning
Batorsky R, Ceasrine AM, Shook LL, Kislal S, Bordt EA, Devlin BA, Perlis RH, Slonim DK, Bilbo SD, Edlow AG
Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity. bioRxiv. 2023 Dec 19.
Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity.
Kelsoe J, Ou A, Rosenthal S, Adli M, Akiyama K, Akula N, Alda M, Amare AT, Ardau R, Arias B, Aubry JM, Backlund L, Banzato C, Bauer M, Baune B, Bellivier F, Benabarre A, Bengesser S, Abesh B, Biernacka J, Bui E, Cervantes P, Chen GB, Chen HC, Chillotti C, Cichon S, Clark S, Colom F, Cousins D, Cruceanu C, Czerski P, Dantas C, Dayer A, Degenhardt F, DePaulo JR, Etain B, Falkai P, Fellendorf F, Ferensztajn-Rochowiak E, Forstner AJ, Frisen L, Frye M, Fullerton J, Gard S, Garnham J, Goes F, Grigoroiu-Serbanescu M, Grof P, Gruber O, Hashimoto R, Hauser J, Heilbronner U, Herms S, Hoffmann P, Hofmann A, Hou L, Jamain S, Jiménez E, Kahn JP, Kassem L, Kato T, Kittel-Schneider S, König B, Kuo PH, Kusumi I, Dalkner N, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband S, Jaramillo CL, MacQueen G, Maj M, Manchia M, Marie-Claire C, Martinsson L, Mattheisen M, McCarthy M, McElroy S, McMahon F, Mitchell P, Mitjans M, Mondimore F, Monteleone P, Nievergelt C, Nöthen M, Novak T, Osby U, Ozaki N, Papiol S, Perlis R, Pfennig A, Potash J, Reich-Erkelenz D, Reif A, Reininghaus E, Rietschel M, Rouleau G, Rybakowski JK, Schalling M, Schofield P, Schubert KO, Schulze T, Schweizer B, Seemüller F, Severino G, Shekhtman T, Shilling P, Shimoda K, Simhandl C, Slaney C, Squassina A, Stamm T, Stopkova P, Tighe S, Tortorella A, Turecki G, Vieta E, Volkert J, Witt S, Wray N, Wright A, Young T, Zandi P, Zompo MD
Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study. Res Sq. 2023 Oct 03.
Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study.
Kishkovich TP, James KE, McCoy TH, Perlis RH, Kaimal AJ, Clapp MA
Performance of a Maternal Risk Stratification System for Predicting Low Apgar Scores. Am J Perinatol. 2024 Oct; 41(13):1808-1814.
Performance of a Maternal Risk Stratification System for Predicting Low Apgar Scores.
Jaywant A, Gunning FM, Oberlin LE, Santillana M, Ognyanova K, Druckman JN, Baum MA, Lazer D, Perlis RH
Cognitive Symptoms of Post-COVID-19 Condition and Daily Functioning. JAMA Netw Open. 2024 02 05; 7(2):e2356098.
Cognitive Symptoms of Post-COVID-19 Condition and Daily Functioning.
Ou AH, Rosenthal SB, Adli M, Akiyama K, Akula N, Alda M, Amare AT, Ardau R, Arias B, Aubry JM, Backlund L, Bauer M, Baune BT, Bellivier F, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Cervantes P, Chen GB, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dantas CR, Dayer A, Del Zompo M, Degenhardt F, DePaulo JR, Étain B, Falkai P, Fellendorf FT, Ferensztajn-Rochowiak E, Forstner AJ, Frisén L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Gruber O, Hashimoto R, Hauser J, Heilbronner U, Herms S, Hoffmann P, Hofmann A, Hou L, Jamain S, Jiménez E, Kahn JP, Kassem L, Kato T, Kittel-Schneider S, König B, Kuo PH, Kusumi I, Lackner N, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Jaramillo CAL, MacQueen G, Maj M, Manchia M, Marie-Claire C, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, McMahon FJ, Mitchell PB, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Novák T, Ösby U, Ozaki N, Papiol S, Perlis RH, Pisanu C, Potash JB, Pfennig A, Reich-Erkelenz D, Reif A, Reininghaus EZ, Rietschel M, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schubert KO, Schulze TG, Schweizer BW, Seemüller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Tighe SK, Tortorella A, Turecki G, Vieta E, Volkert J, Witt S, Wray NR, Wright A, Young LT, Zandi PP, Kelsoe JR
Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study. Transl Psychiatry. 2024 02 23; 14(1):109.
Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study.
Shook LL, Castro VM, Herzberg EM, Fourman LT, Kaimal AJ, Perlis RH, Edlow AG
Offspring cardiometabolic outcomes and postnatal growth trajectories after exposure to maternal SARS-CoV-2 infection. Obesity (Silver Spring). 2024 05; 32(5):969-978.
Offspring cardiometabolic outcomes and postnatal growth trajectories after exposure to maternal SARS-CoV-2 infection.
Koromina M, Ravi A, Panagiotaropoulou G, Schilder BM, Humphrey J, Braun A, Bidgeli T, Chatzinakos C, Coombes B, Kim J, Liu X, Terao C, O 'Connell KS, Adams M, Rolf A, Alda M, Alfredsson L, Andlauer TFM, Andreassen OA, Antoniou A, Baune BT, Bengesser S, Biernacka J, Boehnke M, Bosch R, Cairns MJ, Carr VJ, Casas M, Catts S, Cichon S, Corvin A, Craddock N, Dafnas K, Dalkner N, Dannlowski U, Degenhardt F, Florio AD, Dikeos D, Fellendorf FT, Ferentinos P, Forstner AJ, Forty L, Frye M, Fullerton JM, Gawlik M, Gizer IR, Gordon-Smith K, Green MJ, Grigoroiu-Serbanescu M, Guzman-Parra J, Hahn T, Henskens F, Hillert J, Jablensky AV, Jones L, Jones I, Jonsson L, Kelsoe JR, Kircher T, Kirov G, Kittel-Schneider S, Kogevinas M, Landén M, Leboyer M, Lenger M, Lissowska J, Lochner C, Loughland C, MacIntyre D, Martin NG, Maratou E, Mathews CA, Mayoral F, McElroy SL, McGregor NW, McIntosh A, McQuillin A, Michie P, Mitchell PB, Moutsatsou P, Mowry B, Müller-Myhsok B, Myers RM, Nenadic I, Nievergelt C, Nöthen MM, Nurnberger J, O 'Donovan M, O'Donovan C, Ophoff RA, Owen MJ, Pantelis C, Pato C, Pato MT, Patrinos GP, Pawlak JM, Perlis RH, Porichi E, Posthuma D, Ramos-Quiroga JA, Reif A, Reininghaus EZ, Ribasés M, Rietschel M, Schall U, Schofield PR, Schulze TG, Scott L, Scott RJ, Serretti A, Weickert CS, Smoller JW, Artigas MS, Stein DJ, Streit F, Toma C, Tooney P, Vawter MP, Vieta E, Vincent JB, Waldman ID, Weickert T, Witt SH, Hong KS, Ikeda M, Iwata N, Swiatkowska B, Won HH, Edenberg HJ, Ripke S, Raj T, Coleman JRI, Mullins N
Fine-mapping genomic loci refines bipolar disorder risk genes. medRxiv. 2024 Sep 17.
Fine-mapping genomic loci refines bipolar disorder risk genes.
Tissue- and cell-type-specific molecular and functional signatures of 16p11.2 reciprocal genomic disorder across mouse brain and human neuronal models. Am J Hum Genet. 2024 Mar 07; 111(3):619.
Perlis RH, Goldberg JF, Ostacher MJ, Schneck CD
Clinical decision support for bipolar depression using large language models. Neuropsychopharmacology. 2024 Aug; 49(9):1412-1416.
Clinical decision support for bipolar depression using large language models.
Sharma A, Verhaak PF, McCoy TH, Perlis RH, Doshi-Velez F
Identifying data-driven subtypes of major depressive disorder with electronic health records. J Affect Disord. 2024 07 01; 356:64-70.
Identifying data-driven subtypes of major depressive disorder with electronic health records.
Kang J, Castro VM, Ripperger M, Venkatesh S, Burstein D, Linnér RK, Rocha DB, Hu Y, Wilimitis D, Morley T, Han L, Kim RY, Feng YA, Ge T, Heckers S, Voloudakis G, Chabris C, Roussos P, McCoy TH, Walsh CG, Perlis RH, Ruderfer DM
Genome-Wide Association Study of Treatment-Resistant Depression: Shared Biology With Metabolic Traits. Am J Psychiatry. 2024 Jul 01; 181(7):608-619.
Genome-Wide Association Study of Treatment-Resistant Depression: Shared Biology With Metabolic Traits.
JASPer-MH: Jointly Assessed Scalable Phenotypes for Mental Health
Naik H, Tran KC, Staples JA, Perlis RH, Levin A
Psychiatric Symptoms, Treatment Uptake, and Barriers to Mental Health Care Among US Adults With Post-COVID-19 Condition. JAMA Netw Open. 2024 04 01; 7(4):e248481.
Psychiatric Symptoms, Treatment Uptake, and Barriers to Mental Health Care Among US Adults With Post-COVID-19 Condition.
Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity. Cell Rep. 2024 06 25; 43(6):114326.
Clapp MA, Castro VM, Verhaak P, McCoy TH, Shook LL, Edlow AG, Perlis RH
Stratifying Risk for Postpartum Depression at Time of Hospital Discharge. medRxiv. 2024 May 27.
Stratifying Risk for Postpartum Depression at Time of Hospital Discharge.
Dimensional Measures of Psychopathology in Children and Adolescents Using Large Language Models. Biol Psychiatry. 2024 Dec 15; 96(12):940-947.
Dimensional Measures of Psychopathology in Children and Adolescents Using Large Language Models.
Shook LL, Batorsky RE, De Guzman RM, McCrea LT, Brigida SM, Horng JE, Sheridan SD, Kholod O, Cook AM, Li JZ, Slonim DK, Goods BA, Perlis RH, Edlow AG
Maternal SARS-CoV-2 impacts fetal placental macrophage programs and placenta-derived microglial models of neurodevelopment. J Neuroinflammation. 2024 Jun 25; 21(1):163.
Maternal SARS-CoV-2 impacts fetal placental macrophage programs and placenta-derived microglial models of neurodevelopment.
Rathnam S, Hart KL, Sharma A, Verhaak PF, McCoy TH, Doshi-Velez F, Perlis RH
Heterogeneity in Antidepressant Treatment and Major Depressive Disorder Outcomes Among Clinicians. JAMA Psychiatry. 2024 Oct 01; 81(10):1003-1009.
Heterogeneity in Antidepressant Treatment and Major Depressive Disorder Outcomes Among Clinicians.
Research Letter: Characterizing spin in psychiatric clinical research literature using large language models. medRxiv. 2024 Jul 01.
Research Letter: Characterizing spin in psychiatric clinical research literature using large language models.
Perlis RH, Ognyanova K, Uslu A, Lunz Trujillo K, Santillana M, Druckman JN, Baum MA, Lazer D
Trust in Physicians and Hospitals During the COVID-19 Pandemic in a 50-State Survey of US Adults. JAMA Netw Open. 2024 07 01; 7(7):e2424984.
Trust in Physicians and Hospitals During the COVID-19 Pandemic in a 50-State Survey of US Adults.
Hewitt T, Alural B, Becke N, Sheridan SD, Perlis RH, Lalonde J
Reply to: "Correspondence to bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca2+ entry and accelerated differentiation" by Yde Ohki and colleagues. Mol Psychiatry. 2025 Feb; 30(2):788-790.
Reply to: "Correspondence to bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca2+ entry and accelerated differentiation" by Yde Ohki and colleagues.
Bress JN, Falk A, Schier MM, Jaywant A, Moroney E, Dargis M, Bennett SM, Scult MA, Volpp KG, Asch DA, Balachandran M, Perlis RH, Lee FS, Gunning FM
Efficacy of a Mobile App-Based Intervention for Young Adults With Anxiety Disorders: A Randomized Clinical Trial. JAMA Netw Open. 2024 08 01; 7(8):e2428372.
Efficacy of a Mobile App-Based Intervention for Young Adults With Anxiety Disorders: A Randomized Clinical Trial.
Perlis RH, Uslu A, Schulman J, Himelfarb A, Gunning FM, Solomonov N, Santillana M, Baum MA, Druckman JN, Ognyanova K, Lazer D
Prevalence and correlates of irritability among U.S. adults. Neuropsychopharmacology. 2024 Dec; 49(13):2052-2059.
Prevalence and correlates of irritability among U.S. adults.
Perlis RH, Uslu A, Barroilhet SA, Vohringer PA, Santillana M, Baum MA, Druckman JN, Ognyanova K, Lazer D
Conspiratorial thinking in a 50-state survey of American adults. medRxiv. 2024 Sep 14.
Conspiratorial thinking in a 50-state survey of American adults.
Santillana M, Uslu AA, Urmi T, Quintana-Mathe A, Druckman JN, Ognyanova K, Baum M, Perlis RH, Lazer D
Tracking COVID-19 Infections Using Survey Data on Rapid At-Home Tests. JAMA Netw Open. 2024 09 03; 7(9):e2435442.
Tracking COVID-19 Infections Using Survey Data on Rapid At-Home Tests.
Sylvia LG, Hay A, Ostacher MJ, Miklowitz DJ, Nierenberg AA, Thase ME, Sachs GS, Deckersbach T, Perlis RH
Association between therapeutic alliance, care satisfaction, and pharmacological adherence in bipolar disorder. J Clin Psychopharmacol. 2013 Jun; 33(3):343-50.
Association between therapeutic alliance, care satisfaction, and pharmacological adherence in bipolar disorder.
Kane JM, Perlis RH, DiCarlo LA, Au-Yeung K, Duong J, Petrides G
First experience with a wireless system incorporating physiologic assessments and direct confirmation of digital tablet ingestions in ambulatory patients with schizophrenia or bipolar disorder. J Clin Psychiatry. 2013 Jun; 74(6):e533-40.
First experience with a wireless system incorporating physiologic assessments and direct confirmation of digital tablet ingestions in ambulatory patients with schizophrenia or bipolar disorder.
Cusin C, Iovieno N, Iosifescu DV, Nierenberg AA, Fava M, Rush AJ, Perlis RH
A randomized, double-blind, placebo-controlled trial of pramipexole augmentation in treatment-resistant major depressive disorder. J Clin Psychiatry. 2013 Jul; 74(7):e636-41.
A randomized, double-blind, placebo-controlled trial of pramipexole augmentation in treatment-resistant major depressive disorder.
How Health and Technology Sectors Can Collaborate on Better AI-Assisted Wearables. JAMA. 2024 Nov 12; 332(18):1501-1504.
How Health and Technology Sectors Can Collaborate on Better AI-Assisted Wearables.
Victoria LW, Oberlin LE, Ilieva IP, Jaywant A, Kanellopoulos D, Mercaldi C, Stamatis CA, Farlow DN, Kollins SH, Tisor O, Joshi S, Doreste-Mendez R, Perlis RH, Gunning FM
A digital intervention for cognitive deficits following COVID-19: a randomized clinical trial. Neuropsychopharmacology. 2024 Dec; 50(2):472-479.
A digital intervention for cognitive deficits following COVID-19: a randomized clinical trial.
Doyle AE, Bearden CE, Gur RE, Ledbetter DH, Martin CL, McCoy TH, Pasaniuc B, Perlis RH, Smoller JW, Davis LK
Advancing Mental Health Research Through Strategic Integration of Transdiagnostic Dimensions and Genomics. Biol Psychiatry. 2025 Mar 01; 97(5):450-460.
Advancing Mental Health Research Through Strategic Integration of Transdiagnostic Dimensions and Genomics.
The VA Was an Early Adopter of Artificial Intelligence to Improve Care-Here's What They Learned. JAMA. 2024 Nov 05; 332(17):1411-1414.
The VA Was an Early Adopter of Artificial Intelligence to Improve Care-Here's What They Learned.
Moran LV, Skinner JP, Shinn AK, Nielsen K, Rao V, Taylor ST, Cohen TR, Erkol C, Merchant J, Mujica CA, Perlis RH, Ongur D
Risk of Incident Psychosis and Mania With Prescription Amphetamines. Am J Psychiatry. 2024 Oct 01; 181(10):901-909.
Risk of Incident Psychosis and Mania With Prescription Amphetamines.
Clapp MA, Li S, James KE, Reiff ES, Little SE, McCoy TH, Perlis RH, Kaimal AJ
Development of a Practical Prediction Model for Adverse Neonatal Outcomes at the Start of the Second Stage of Labor. Obstet Gynecol. 2025 Jan 01; 145(1):73-81.
Development of a Practical Prediction Model for Adverse Neonatal Outcomes at the Start of the Second Stage of Labor.
Oh DS, Kim E, Normand R, Lu G, Shook LL, Lyall A, Jasset O, Demidkin S, Gilbert E, Kim J, Akinwunmi B, Tantivit J, Tirard A, Arnold BY, Slowikowski K, Goldberg MB, Filbin MR, Hacohen N, Nguyen LH, Chan AT, Yu XG, Li JZ, Yonker L, Fasano A, Perlis RH, Pasternak O, Gray KJ, Choi GB, Drew DA, Sen P, Villani AC, Edlow AG, Huh JR
SARS-CoV-2 infection elucidates features of pregnancy-specific immunity. Cell Rep. 2024 11 26; 43(11):114933.
SARS-CoV-2 infection elucidates features of pregnancy-specific immunity.
FDA Commissioner Robert Califf on Setting Guardrails for AI in Health Care. JAMA. 2024 Dec 17; 332(23):1963-1966.
FDA Commissioner Robert Califf on Setting Guardrails for AI in Health Care.
Health Systems Are Struggling to Keep Up With AI-A National Registration System Could Help. JAMA. 2025 Jan 21; 333(3):190-193.
Health Systems Are Struggling to Keep Up With AI-A National Registration System Could Help.
Researchers Compared Hospital Early Warning Scores for Clinical Deterioration-Here's What They Learned. JAMA. 2025 Feb 04; 333(5):363-365.
Researchers Compared Hospital Early Warning Scores for Clinical Deterioration-Here's What They Learned.
The Low-Cost, Battery-Powered AI-Enabled Ultrasound Device That Could Improve Global Obstetric Care. JAMA. 2025 Jan 14; 333(2):106-108.
The Low-Cost, Battery-Powered AI-Enabled Ultrasound Device That Could Improve Global Obstetric Care.
Perlis RH, Uslu A, Schulman J, Gunning FM, Santillana M, Baum MA, Druckman JN, Ognyanova K, Lazer D
Irritability and Social Media Use in US Adults. JAMA Netw Open. 2025 01 02; 8(1):e2452807.
Irritability and Social Media Use in US Adults.
McGrath LM, Cornelis MC, Lee PH, Robinson EB, Duncan LE, Barnett JH, Huang J, Gerber G, Sklar P, Sullivan P, Perlis RH, Smoller JW
Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2013 Dec; 162B(8):779-88.
Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.
Packer CH, Jasset O, Hanniford N, Brigida S, Demidkin S, Perlis RH, Edlow AG, Shook LL
Maternal-fetal cytokine profiles in acute SARS-CoV-2 "breakthrough" infection after COVID-19 vaccination. Front Immunol. 2024; 15:1506203.
Maternal-fetal cytokine profiles in acute SARS-CoV-2 "breakthrough" infection after COVID-19 vaccination.
Researchers Tested an AI Tool That Drafts Responses to Patient Messages-Here's What They Found. JAMA. 2025 Feb 25; 333(8):649-651.
Researchers Tested an AI Tool That Drafts Responses to Patient Messages-Here's What They Found.
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Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet. 2013 Sep; 45(9):984-94.
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
Research Domain Criteria in NIMH Grants Characterized Using Large Language Models. JAMA Netw Open. 2025 02 03; 8(2):e2459371.
Research Domain Criteria in NIMH Grants Characterized Using Large Language Models.
Study Finds People Prefer AI Over Clinician Responses to Questions in the Electronic Medical Record. JAMA. 2025 Mar 04; 333(9):738-740.
Study Finds People Prefer AI Over Clinician Responses to Questions in the Electronic Medical Record.
Characterizing Spin in Psychiatric Clinical Research Literature Using Large Language Models. JAMA Netw Open. 2025 Feb 03; 8(2):e2459500.
Characterizing Spin in Psychiatric Clinical Research Literature Using Large Language Models.
Study Finds Most Older Adults Use Digital Health Technologies, Plus Some Surprises. JAMA. 2025 Mar 11; 333(10):829-831.
Study Finds Most Older Adults Use Digital Health Technologies, Plus Some Surprises.
Pacchiarotti I, Bond DJ, Baldessarini RJ, Nolen WA, Grunze H, Licht RW, Post RM, Berk M, Goodwin GM, Sachs GS, Tondo L, Findling RL, Youngstrom EA, Tohen M, Undurraga J, González-Pinto A, Goldberg JF, Yildiz A, Altshuler LL, Calabrese JR, Mitchell PB, Thase ME, Koukopoulos A, Colom F, Frye MA, Malhi GS, Fountoulakis KN, Vázquez G, Perlis RH, Ketter TA, Cassidy F, Akiskal H, Azorin JM, Valentí M, Mazzei DH, Lafer B, Kato T, Mazzarini L, Martínez-Aran A, Parker G, Souery D, Ozerdem A, McElroy SL, Girardi P, Bauer M, Yatham LN, Zarate CA, Nierenberg AA, Birmaher B, Kanba S, El-Mallakh RS, Serretti A, Rihmer Z, Young AH, Kotzalidis GD, MacQueen GM, Bowden CL, Ghaemi SN, Lopez-Jaramillo C, Rybakowski J, Ha K, Perugi G, Kasper S, Amsterdam JD, Hirschfeld RM, Kapczinski F, Vieta E
The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders. Am J Psychiatry. 2013 Nov; 170(11):1249-62.
The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders.
Targeting Schizophrenia. Am J Psychiatry. 2025 Apr 01; 182(4):329-331.
Diabetic Retinopathy Is Massively Underscreened-An AI System Could Help. JAMA. 2025 May 20; 333(19):1653-1655.
Diabetic Retinopathy Is Massively Underscreened-An AI System Could Help.
Machine Learning Model Shows Promise in Early Detection of Serious Mental Illness. JAMA. 2025 Apr 08; 333(14):1189-1191.
Machine Learning Model Shows Promise in Early Detection of Serious Mental Illness.
Self-reported Health Service Utilization and Barriers to Care Among US Adults with a History of Post COVID-19 Condition. J Gen Intern Med. 2025 04; 40(5):1059-1069.
Self-reported Health Service Utilization and Barriers to Care Among US Adults with a History of Post COVID-19 Condition.
How an Economist's Application of Machine Learning to Target Nudges Applies to Precision Medicine. JAMA. 2025 Jun 17; 333(23):2037-2039.
How an Economist's Application of Machine Learning to Target Nudges Applies to Precision Medicine.
Correction: N-3 polyunsaturated fatty acids promote astrocyte differentiation and neurotrophin production independent of cAMP in patient-derived neural stem cells. Mol Psychiatry. 2025 Jul; 30(7):3360.
Correction: N-3 polyunsaturated fatty acids promote astrocyte differentiation and neurotrophin production independent of cAMP in patient-derived neural stem cells.
Can Open-Source AI Models Diagnose Complex Cases as Well as GPT-4? JAMA. 2025 May 06; 333(17):1473-1475.
Can Open-Source AI Models Diagnose Complex Cases as Well as GPT-4?
McCrea LT, Batorsky RE, Bowen JJ, Yeh H, Thanos JM, Fu T, Perlis RH, Sheridan SD
Identifying brain-penetrant small-molecule modulators of human microglia using a cellular model of synaptic pruning. Neuropsychopharmacology. 2025 Sep; 50(10):1544-1552.
Identifying brain-penetrant small-molecule modulators of human microglia using a cellular model of synaptic pruning.
Study Findings Question Value of Including Race in Prenatal Screening for Birth Defects. JAMA. 2025 Apr 22; 333(16):1380-1382.
Study Findings Question Value of Including Race in Prenatal Screening for Birth Defects.
Reasoning language models for more transparent prediction of suicide risk. BMJ Ment Health. 2025 May 11; 28(1).
Reasoning language models for more transparent prediction of suicide risk.
Estimating depression severity in narrative clinical notes using large language models. J Affect Disord. 2025 Jul 15; 381:270-274.
Estimating depression severity in narrative clinical notes using large language models.
Stratifying Risk for Postpartum Depression at Time of Hospital Discharge. Am J Psychiatry. 2025 Jun 01; 182(6):551-559.
Pharmacogenomic testing and personalized treatment of depression. Clin Chem. 2014 Jan; 60(1):53-9.
Pharmacogenomic testing and personalized treatment of depression.
Scalable Phenotyping to Assay Risk in Childhood after eXposures in Pregnancy: SPARC-XP
Ostacher MJ, Iosifescu DV, Hay A, Blumenthal SR, Sklar P, Perlis RH
Pilot investigation of isradipine in the treatment of bipolar depression motivated by genome-wide association. Bipolar Disord. 2014 Mar; 16(2):199-203.
Pilot investigation of isradipine in the treatment of bipolar depression motivated by genome-wide association.
Major depressive disorder in DSM-5: implications for clinical practice and research of changes from DSM-IV. Depress Anxiety. 2014 Jun; 31(6):459-71.
Major depressive disorder in DSM-5: implications for clinical practice and research of changes from DSM-IV.
Characterizing research domain criteria symptoms among psychiatric inpatients using large language models. J Mood Anxiety Disord. 2024 Dec; 8:100079.
Characterizing research domain criteria symptoms among psychiatric inpatients using large language models.
Rathnam S, Sharma A, Hart KL, Verhaak PF, McCoy TH, Perlis RH, Doshi-Velez F
Association between prescriber practices and major depression treatment outcomes. J Mood Anxiety Disord. 2024 Dec; 8:100080.
Association between prescriber practices and major depression treatment outcomes.
Vöhringer PA, Barroilhet SA, Palma BA, Perlis RH
Antidepressant Remission and Manic Switch in Bipolar Depression: A Propensity Score Analysis. Acta Psychiatr Scand. 2025 Sep; 152(3):228-235.
Antidepressant Remission and Manic Switch in Bipolar Depression: A Propensity Score Analysis.
Applying large language models to stratify suicide risk using narrative clinical notes. J Mood Anxiety Disord. 2025 Jun; 10:100109.
Applying large language models to stratify suicide risk using narrative clinical notes.
Perlis RH, Verhaak PF, Goldberg J, Cusin C, Ostacher M, Malhi GS, Zarate CA, Shelton RC, Iosifescu DV, Tohen M, Jha MK, Sajatovic M, Berk M
Clinical decision support for pharmacologic management of treatment-resistant depression with augmented large language models. J Mood Anxiety Disord. 2025 Dec; 12:100142.
Clinical decision support for pharmacologic management of treatment-resistant depression with augmented large language models.
Jaywant A, Dunlop K, Victoria LW, Oberlin L, Lynch CJ, Respino M, Kuceyeski A, Scult M, Hoptman MJ, Liston C, O'Dell MW, Alexopoulos GS, Perlis RH, Gunning FM
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
Estimated Regional White Matter Hyperintensity Burden, Resting State Functional Connectivity, and Cognitive Functions in Older Adults. Am J Geriatr Psychiatry. 2022 03; 30(3):269-280.
Estimated Regional White Matter Hyperintensity Burden, Resting State Functional Connectivity, and Cognitive Functions in Older Adults.
Obradovich N, Khalsa SS, Khan W, Suh J, Perlis RH, Ajilore O, Paulus MP
NPP - digital psychiatry and neuroscience
Opportunities and Risks of Large Language Models in Psychiatry. NPP Digit Psychiatry Neurosci. 2024; 2(1).
Opportunities and Risks of Large Language Models in Psychiatry.
Walsh CG, Ripperger M, McCoy TH, Castro V, Hu Y, Kirchner HL, Ruderfer D, Perlis RH
Generalizability of Risk Models for Treatment-Resistant Depression Across Three Health Systems. medRxiv. 2025 May 27.
Generalizability of Risk Models for Treatment-Resistant Depression Across Three Health Systems.
Perlis RH, Gunning FM, Santillana M, Baum MA, Druckman JN, Ognyanova K, Lazer D
Derivation of a 3-Item Patient Health Questionnaire as a Shortened Survey to Capture Depressive Symptoms. JAMA Netw Open. 2025 07 01; 8(7):e2522036.
Derivation of a 3-Item Patient Health Questionnaire as a Shortened Survey to Capture Depressive Symptoms.
Desai AN, Jacobs E, Ogedegbe O, Rubenfeld G, Berlin J, Shulman L, O'Cearbhaill R, Studenski S, Powell E, Mmeje O, Trueger NS, Chino F, Perlis R, Fihn S, Perencevich E
The Global Public Health Imperative-Where Do We Go From Here? JAMA Netw Open. 2025 May 01; 8(5):e2517283.
The Global Public Health Imperative-Where Do We Go From Here?
Ognyanova K, Druckman JN, Schulman J, Baum MA, Perlis RH, Lazer D
Information from social ties predicts conspiracy beliefs: Evidence from the attempted assassination of Donald Trump. PNAS Nexus. 2025 Jun; 4(6):pgaf193.
Information from social ties predicts conspiracy beliefs: Evidence from the attempted assassination of Donald Trump.
Gross CP, Richman IB, Stall NM, Kneifati-Hayek JZ, Allore HG, Rittenberg E, Katz MH, Grady D, Durant RW, Anderson TS, Tripodis Y, Wang TY, Corbie G, Mody L, Perlis RH, Ganguli I, Inouye SK
Artificial Intelligence and Clinical Care: JAMA Internal Medicine Call for Papers. JAMA Intern Med. 2025 Dec 01; 185(12):1418-1420.
Artificial Intelligence and Clinical Care: JAMA Internal Medicine Call for Papers.
Angus DC, Khera R, Lieu T, Liu V, Ahmad FS, Anderson B, Bhavani SV, Bindman A, Brennan T, Celi LA, Chen F, Cohen IG, Denniston A, Desai S, Embí P, Faisal A, Ferryman K, Gerhart J, Gross M, Hernandez-Boussard T, Howell M, Johnson K, Lee K, Liu X, Lomis K, London AJ, Longhurst CA, Mandl KD, McGlynn E, Mello MM, Munoz F, Ohno-Machado L, Ouyang D, Perlis R, Phillips A, Rhew D, Ross JS, Saria S, Schwamm L, Seymour CW, Shah NH, Shah R, Singh K, Solomon M, Spates K, Spector-Bagdady K, Wang T, Gichoya JW, Weinstein J, Wiens J, Bibbins-Domingo K
AI, Health, and Health Care Today and Tomorrow: The JAMA Summit Report on Artificial Intelligence. JAMA. 2025 11 11; 334(18):1650-1664.
AI, Health, and Health Care Today and Tomorrow: The JAMA Summit Report on Artificial Intelligence.
Urmi T, Pant B, Dewey G, Quintana-Mathe A, Lang I, Druckman J, Ognyanova K, Baum M, Perlis R, Riedl C, Lazer D, Santillana M
Proceedings of the National Academy of Sciences of the United States of America
Characterizing population-level changes in human behavior during the COVID-19 pandemic in the United States. Proc Natl Acad Sci U S A. 2025 Sep 16; 122(37):e2500655122.
Characterizing population-level changes in human behavior during the COVID-19 pandemic in the United States.
Predicting hospice eligibility among dementia patients using language models. Alzheimers Dement. 2025 Nov; 21(11):e70878.
Predicting hospice eligibility among dementia patients using language models.
Artificial Intelligence and the Potential Transformation of Mental Health. JAMA Psychiatry. 2026 Apr 01; 83(4):409-413.
Artificial Intelligence and the Potential Transformation of Mental Health.
Indirect costs and scientific impact at NIMH. PNAS Nexus. 2025 Nov; 4(11):pgaf357.
Indirect costs and scientific impact at NIMH.
Perlis RH, Gunning FM, Uslu AA, Santillana M, Baum MA, Druckman JN, Ognyanova K, Lazer D
Generative AI Use and Depressive Symptoms Among US Adults. JAMA Netw Open. 2026 Jan 02; 9(1):e2554820.
Generative AI Use and Depressive Symptoms Among US Adults.
Ramachandiran AK, Gunning F, Santillana M, Baum MA, Verhaak PF, Druckman JN, Ognyanova K, Lazer D, Perlis RH
Sociodemographic disparities, healthcare system trust, and social support in mental health treatment among U.S. adults with depressive or anxiety symptoms. J Mood Anxiety Disord. 2026 Mar; 13:100166.
Sociodemographic disparities, healthcare system trust, and social support in mental health treatment among U.S. adults with depressive or anxiety symptoms.
Musacchio Schafer K, Franklin J, Perlis RH, Walsh C
Barriers and Solutions to Efficient Health Care AI Implementation. JAMA Netw Open. 2025 Nov 03; 8(11):e2544086.
Barriers and Solutions to Efficient Health Care AI Implementation.
Perlis RH, Ramachandiran AK, Verhaak PF, Santillana M, Baum MA, Druckman JN, Ognyanova K, Lazer D
Antidepressant use among American adults in a 50-state survey. BMJ Ment Health. 2026 Jan 21; 29(1).
Antidepressant use among American adults in a 50-state survey.
Goldberg JF, McIntyre RS, Swartz HA, Freeman MP, Mago R, Citrome L, Rosenblat JD, Thase ME, Tohen M, Vieta E, Malhi GS, Sajatovic M, Shelton RC, Macaluso M, Berk M, Perlis RH, Ostacher MJ, Khan A, Iosifescu DV, Sanacora G, Rubio JM, Kane JM, Goodman DW, Nierenberg AA, Correll CU, Kupka R, Kasper S, Furukawa TA, Davis L, Aaronson ST, Gitlin MJ, Jha MK, Cohen LJ, Papakostas GI, Mitchell PB, Gorwood P, Gupta S, Frye MA, Young AH, Zohar J, Steingard S, Zarate CA, Clayton AH
Recommendations for the Deprescribing of Psychotropic Medications: A Consensus Statement From the American Society of Clinical Psychopharmacology Task Force. JAMA Netw Open. 2026 Feb 02; 9(2):e260043.
Recommendations for the Deprescribing of Psychotropic Medications: A Consensus Statement From the American Society of Clinical Psychopharmacology Task Force.
Accuracy of Attestation Among Micrographic Dermatologic Surgery Diplomates. JAMA Netw Open. 2022 09 01; 5(9):e2229795.
Accuracy of Attestation Among Micrographic Dermatologic Surgery Diplomates.
Ashar YK, Lumley MA, Perlis RH, Liston C, Gunning FM, Wager TD
Reattribution to Mind-Brain Processes and Recovery From Chronic Back Pain: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2023 09 05; 6(9):e2333846.
Reattribution to Mind-Brain Processes and Recovery From Chronic Back Pain: A Secondary Analysis of a Randomized Clinical Trial.
Perlis RH, Uslu A, Barroilhet SA, Vohringer PA, Ramachandiran AK, Santillana M, Baum MA, Druckman JN, Ognyanova K, Lazer D
Conspiratorial thinking in a 50-state survey of American adults. J Affect Disord. 2025 Dec 01; 390:119915.
Jaywant A, Bress JN, Lynch CJ, Mir Z, Schier MM, Bukhari H, Brown H, Falk A, Bennett S, Perlis RH, Liston C, Lee FS, Gunning FM
Cognitive Behavioral Therapy App, Resting State Functional Connectivity, and Anxiety. JAMA Netw Open. 2025 Jul 01; 8(7):e2524498.
Cognitive Behavioral Therapy App, Resting State Functional Connectivity, and Anxiety.
Druckman JN, Ognyanova K, Safarpour A, Schulman J, Lunz Trujillo K, Uslu AA, Green J, Baum MA, Quintana-Mathé A, Qu H, Perlis RH, Lazer DMJ
Representation in science and trust in scientists in the USA. Nat Hum Behav. 2026 Mar; 10(3):476-491.
Representation in science and trust in scientists in the USA.
Applying Clinical Licensure Principles to Artificial Intelligence. JAMA Intern Med. 2026 Jan 01; 186(1):13.
Applying Clinical Licensure Principles to Artificial Intelligence.
Perlis RH, Flanagin A, Kendall-Taylor J, Berkwits M, Bibbins-Domingo K
Author Disclosure of Use of AI in Submissions to 13 JAMA Network Journals. JAMA. 2026 Feb 24; 335(8):717-719.
Author Disclosure of Use of AI in Submissions to 13 JAMA Network Journals.
Horng JE, McCrea LT, Batorsky RE, Bowen JJ, Boschian C, Song Y, Perlis RH, Sheridan SD
Functional Genomic Profiling of Schizophrenia-Associated Genes Reveals Key Microglial Regulators. bioRxiv. 2025 Nov 14.
Functional Genomic Profiling of Schizophrenia-Associated Genes Reveals Key Microglial Regulators.
AI in Peer Review-Reply. JAMA. 2026 Feb 10; 335(6):550.
Papageorgiou G, Ibrahim EC, Gorgievski V, Maxson G, Lozano E, Gordon E, Lefrere A, Toupet MJ, Courtet P, Belzeaux R, Foster J, Carmody T, Perlis RH, Trivedi MH, Tzavara ET, Mellios N
A brain-enriched circRNA blood biomarker can predict response to SSRI antidepressants. Mol Psychiatry. 2026 Feb 17.
A brain-enriched circRNA blood biomarker can predict response to SSRI antidepressants.
Translation: screening for novel therapeutics with disease-relevant cell types derived from human stem cell models. Biol Psychiatry. 2014 Jun 15; 75(12):952-60.
Translation: screening for novel therapeutics with disease-relevant cell types derived from human stem cell models.
Wiste A, Robinson EB, Milaneschi Y, Meier S, Ripke S, Clements CC, Fitzmaurice GM, Rietschel M, Penninx BW, Smoller JW, Perlis RH
Bipolar polygenic loading and bipolar spectrum features in major depressive disorder. Bipolar Disord. 2014 Sep; 16(6):608-16.
Bipolar polygenic loading and bipolar spectrum features in major depressive disorder.
Wang JL, Shamah SM, Sun AX, Waldman ID, Haggarty SJ, Perlis RH
Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness. Transl Psychiatry. 2014 Aug 26; 4:e428.
Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness.
Blumenthal SR, Castro VM, Clements CC, Rosenfield HR, Murphy SN, Fava M, Weilburg JB, Erb JL, Churchill SE, Kohane IS, Smoller JW, Perlis RH
An electronic health records study of long-term weight gain following antidepressant use. JAMA Psychiatry. 2014 Aug; 71(8):889-96.
An electronic health records study of long-term weight gain following antidepressant use.
O'Dushlaine C, Ripke S, Ruderfer DM, Hamilton SP, Fava M, Iosifescu DV, Kohane IS, Churchill SE, Castro VM, Clements CC, Blumenthal SR, Murphy SN, Smoller JW, Perlis RH
Rare copy number variation in treatment-resistant major depressive disorder. Biol Psychiatry. 2014 Oct 01; 76(7):536-41.
Rare copy number variation in treatment-resistant major depressive disorder.
Robinson EB, Samocha KE, Kosmicki JA, McGrath L, Neale BM, Perlis RH, Daly MJ
Autism spectrum disorder severity reflects the average contribution of de novo and familial influences. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15161-5.
Autism spectrum disorder severity reflects the average contribution of de novo and familial influences.
Fagerness J, Fonseca E, Hess GP, Scott R, Gardner KR, Koffler M, Fava M, Perlis R, Brennan FX, Lombard J
Pharmacogenetic-guided psychiatric intervention associated with increased adherence and cost savings. Am J Manag Care. 2014 05; 20(5):e146-56.
Pharmacogenetic-guided psychiatric intervention associated with increased adherence and cost savings.
Use of large data sets and the future of personalized treatment. Depress Anxiety. 2014 Nov; 31(11):916-9.
Use of large data sets and the future of personalized treatment.
Clements CC, Castro VM, Blumenthal SR, Rosenfield HR, Murphy SN, Fava M, Erb JL, Churchill SE, Kaimal AJ, Doyle AE, Robinson EB, Smoller JW, Kohane IS, Perlis RH
Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system. Mol Psychiatry. 2015 Jun; 20(6):727-34.
Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system.
Rotstein BH, Liang SH, Belov VV, Livni E, Levine DB, Bonab AA, Papisov MI, Perlis RH, Vasdev N
Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, a Calcium Channel Antagonist. Molecules. 2015 May 26; 20(6):9550-9.
Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, a Calcium Channel Antagonist.
From bench to bedlam. Am J Psychiatry. 2014 Dec 01; 171(12):1233-5.
Bavamian S, Mellios N, Lalonde J, Fass DM, Wang J, Sheridan SD, Madison JM, Zhou F, Rueckert EH, Barker D, Perlis RH, Sur M, Haggarty SJ
Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder. Mol Psychiatry. 2015 May; 20(5):573-84.
Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder.
Uher R, Ripke S, Müller-Myhsok B, Lewis CM, Perlis RH
Association of a brain methylation site with clinical outcomes in depression does not replicate across populations. Am J Psychiatry. 2015 Apr; 172(4):395-7.
Association of a brain methylation site with clinical outcomes in depression does not replicate across populations.
Yoshimizu T, Pan JQ, Mungenast AE, Madison JM, Su S, Ketterman J, Ongur D, McPhie D, Cohen B, Perlis R, Tsai LH
Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Mol Psychiatry. 2015 Feb; 20(2):162-9.
Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons.
Gilman SE, Ni MY, Dunn EC, Breslau J, McLaughlin KA, Smoller JW, Perlis RH
Contributions of the social environment to first-onset and recurrent mania. Mol Psychiatry. 2015 Mar; 20(3):329-36.
Contributions of the social environment to first-onset and recurrent mania.
McCoy TH, Castro VM, Rosenfield HR, Cagan A, Kohane IS, Perlis RH
A clinical perspective on the relevance of research domain criteria in electronic health records. Am J Psychiatry. 2015 Apr; 172(4):316-20.
A clinical perspective on the relevance of research domain criteria in electronic health records.
Ramos EM, Gillis T, Mysore JS, Lee JM, Alonso I, Gusella JF, Smoller JW, Sklar P, MacDonald ME, Perlis RH
Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder. Bipolar Disord. 2015 Jun; 17(4):403-8.
Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder.
Noncoding RNAs connect genetic risk factors to the neurodevelopmental basis of bipolar disorder. Mol Psychiatry. 2015 May; 20(5):548.
Noncoding RNAs connect genetic risk factors to the neurodevelopmental basis of bipolar disorder.
Madison JM, Zhou F, Nigam A, Hussain A, Barker DD, Nehme R, van der Ven K, Hsu J, Wolf P, Fleishman M, O'Dushlaine C, Rose S, Chambert K, Lau FH, Ahfeldt T, Rueckert EH, Sheridan SD, Fass DM, Nemesh J, Mullen TE, Daheron L, McCarroll S, Sklar P, Perlis RH, Haggarty SJ
Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities. Mol Psychiatry. 2015 Jun; 20(6):703-17.
Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities.
Castro VM, Minnier J, Murphy SN, Kohane I, Churchill SE, Gainer V, Cai T, Hoffnagle AG, Dai Y, Block S, Weill SR, Nadal-Vicens M, Pollastri AR, Rosenquist JN, Goryachev S, Ongur D, Sklar P, Perlis RH, Smoller JW
Validation of electronic health record phenotyping of bipolar disorder cases and controls. Am J Psychiatry. 2015 Apr; 172(4):363-72.
Validation of electronic health record phenotyping of bipolar disorder cases and controls.
Monotherapy Antidepressant Treatment is Not Associated With Mania in Bipolar I Disorder. Am J Psychiatry. 2015 Jun; 172(6):586.
Monotherapy Antidepressant Treatment is Not Associated With Mania in Bipolar I Disorder.
A tool to utilize adverse effect profiles to identify brain-active medications for repurposing. Int J Neuropsychopharmacol. 2015 Feb; 18(3).
A tool to utilize adverse effect profiles to identify brain-active medications for repurposing.
Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons. Mol Psychiatry. 2015 Feb; 20(2):284.
Castro VM, McCoy TH, Cagan A, Rosenfield HR, Murphy SN, Churchill SE, Kohane IS, Perlis RH
Stratification of risk for hospital admissions for injury related to fall: cohort study. BMJ. 2014 Oct 24; 349:g5863.
Stratification of risk for hospital admissions for injury related to fall: cohort study.
Uchida M, Spencer AE, Biederman J, Castro VM, Kenworthy T, Chan J, Rosales AM, Newton-Cheh C, Perlis RH
Journal of developmental and behavioral pediatrics : JDBP
A Systematic Evaluation of the QTc Interval and Antidepressants in Youth: An Electronic Health Record Study. J Dev Behav Pediatr. 2015 Jul-Aug; 36(6):434-9.
A Systematic Evaluation of the QTc Interval and Antidepressants in Youth: An Electronic Health Record Study.
Lifetime prevalence of anxiety disorders in people with bipolar disorder: a systematic review and meta-analysis. Lancet Psychiatry. 2015 Aug; 2(8):710-717.
Lifetime prevalence of anxiety disorders in people with bipolar disorder: a systematic review and meta-analysis.
McCoy TH, Castro VM, Cagan A, Roberson AM, Kohane IS, Perlis RH
Sentiment Measured in Hospital Discharge Notes Is Associated with Readmission and Mortality Risk: An Electronic Health Record Study. PLoS One. 2015; 10(8):e0136341.
Sentiment Measured in Hospital Discharge Notes Is Associated with Readmission and Mortality Risk: An Electronic Health Record Study.
Getting Past Proof of Concept For New Treatments. Am J Psychiatry. 2015 Oct; 172(10):937-8.
Getting Past Proof of Concept For New Treatments.
Brennan FX, Gardner KR, Lombard J, Perlis RH, Fava M, Harris HW, Scott R
The primary care companion for CNS disorders
A Naturalistic Study of the Effectiveness of Pharmacogenetic Testing to Guide Treatment in Psychiatric Patients With Mood and Anxiety Disorders. Prim Care Companion CNS Disord. 2015; 17(2).
A Naturalistic Study of the Effectiveness of Pharmacogenetic Testing to Guide Treatment in Psychiatric Patients With Mood and Anxiety Disorders.
Castro VM, Kong SW, Clements CC, Brady R, Kaimal AJ, Doyle AE, Robinson EB, Churchill SE, Kohane IS, Perlis RH
Absence of evidence for increase in risk for autism or attention-deficit hyperactivity disorder following antidepressant exposure during pregnancy: a replication study. Transl Psychiatry. 2016 Jan 05; 6:e708.
Absence of evidence for increase in risk for autism or attention-deficit hyperactivity disorder following antidepressant exposure during pregnancy: a replication study.
Discriminating Between Bipolar Disorder and Major Depressive Disorder. Psychiatr Clin North Am. 2016 Mar; 39(1):1-10.
Discriminating Between Bipolar Disorder and Major Depressive Disorder.
Castro VM, Roberson AM, McCoy TH, Wiste A, Cagan A, Smoller JW, Rosenbaum JF, Ostacher M, Perlis RH
Stratifying Risk for Renal Insufficiency Among Lithium-Treated Patients: An Electronic Health Record Study. Neuropsychopharmacology. 2016 Mar; 41(4):1138-43.
Stratifying Risk for Renal Insufficiency Among Lithium-Treated Patients: An Electronic Health Record Study.
Sylvia LG, Gold AK, Stange JP, Peckham AD, Deckersbach T, Calabrese JR, Weiss RD, Perlis RH, Nierenberg AA, Ostacher MJ
A randomized, placebo-controlled proof-of-concept trial of adjunctive topiramate for alcohol use disorders in bipolar disorder. Am J Addict. 2016 Mar; 25(2):94-8.
A randomized, placebo-controlled proof-of-concept trial of adjunctive topiramate for alcohol use disorders in bipolar disorder.
McGrath LM, Braaten EB, Doty ND, Willoughby BL, Wilson HK, O'Donnell EH, Colvin MK, Ditmars HL, Blais JE, Hill EN, Metzger A, Perlis RH, Willcutt EG, Smoller JW, Waldman ID, Faraone SV, Seidman LJ, Doyle AE
Extending the 'cross-disorder' relevance of executive functions to dimensional neuropsychiatric traits in youth. J Child Psychol Psychiatry. 2016 Apr; 57(4):462-71.
Extending the 'cross-disorder' relevance of executive functions to dimensional neuropsychiatric traits in youth.
Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Banzato CEM, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Brichant-Petitjean C, Bui ET, Cervantes P, Chen GB, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dantas CR, Dayer A, Étain B, Falkai P, Forstner AJ, Frisén L, Fullerton JM, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Lackner N, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Jaramillo CAL, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Ösby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemüller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller JW, Squassina A, Stamm T, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt S, Wright A, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus EZ, Novák T, Aubry JM, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo PH, Kato T, Grigoroiu-Serbanescu M, Reif A, Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe JR, Alda M, Rietschel M, McMahon FJ, Schulze TG
Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. Lancet. 2016 Mar 12; 387(10023):1085-1093.
Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study.
Roberson AM, Castro VM, Cagan A, Perlis RH
Antidepressant nonadherence in routine clinical settings determined from discarded blood samples. J Clin Psychiatry. 2016 Mar; 77(3):359-62.
Antidepressant nonadherence in routine clinical settings determined from discarded blood samples.
Venkatesh KK, Riley L, Castro VM, Perlis RH, Kaimal AJ
Association of Antenatal Depression Symptoms and Antidepressant Treatment With Preterm Birth. Obstet Gynecol. 2016 05; 127(5):926-933.
Association of Antenatal Depression Symptoms and Antidepressant Treatment With Preterm Birth.
Haggarty SJ, Silva MC, Cross A, Brandon NJ, Perlis RH
Advancing drug discovery for neuropsychiatric disorders using patient-specific stem cell models. Mol Cell Neurosci. 2016 06; 73:104-15.
Advancing drug discovery for neuropsychiatric disorders using patient-specific stem cell models.
Physician Payments from Industry Are Associated with Greater Medicare Part D Prescribing Costs. PLoS One. 2016; 11(5):e0155474.
Physician Payments from Industry Are Associated with Greater Medicare Part D Prescribing Costs.
Balekian DS, Linnemann RW, Castro VM, Perlis R, Thadhani R, Camargo CA
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Pre-birth cohort study of atopic dermatitis and severe bronchiolitis during infancy. Pediatr Allergy Immunol. 2016 06; 27(4):413-8.
Pre-birth cohort study of atopic dermatitis and severe bronchiolitis during infancy.
Manchia M, Adli M, Akula N, Ardau R, Aubry JM, Backlund L, Banzato CE, Baune BT, Bellivier F, Bengesser S, Biernacka JM, Brichant-Petitjean C, Bui E, Calkin CV, Cheng AT, Chillotti C, Cichon S, Clark S, Czerski PM, Dantas C, Zompo MD, Depaulo JR, Detera-Wadleigh SD, Etain B, Falkai P, Frisén L, Frye MA, Fullerton J, Gard S, Garnham J, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Heilbronner U, Hoban R, Hou L, Jamain S, Kahn JP, Kassem L, Kato T, Kelsoe JR, Kittel-Schneider S, Kliwicki S, Kuo PH, Kusumi I, Laje G, Lavebratt C, Leboyer M, Leckband SG, López Jaramillo CA, Maj M, Malafosse A, Martinsson L, Masui T, Mitchell PB, Mondimore F, Monteleone P, Nallet A, Neuner M, Novák T, O'Donovan C, Osby U, Ozaki N, Perlis RH, Pfennig A, Potash JB, Reich-Erkelenz D, Reif A, Reininghaus E, Richardson S, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schubert OK, Schweizer B, Seemüller F, Grigoroiu-Serbanescu M, Severino G, Seymour LR, Slaney C, Smoller JW, Squassina A, Stamm T, Steele J, Stopkova P, Tighe SK, Tortorella A, Turecki G, Wray NR, Wright A, Zandi PP, Zilles D, Bauer M, Rietschel M, McMahon FJ, Schulze TG, Alda M
Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report. PLoS One. 2013; 8(6):e65636.
Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report.
Corral-Frías NS, Pizzagalli DA, Carré JM, Michalski LJ, Nikolova YS, Perlis RH, Fagerness J, Lee MR, Conley ED, Lancaster TM, Haddad S, Wolf A, Smoller JW, Hariri AR, Bogdan R
COMT Val(158) Met genotype is associated with reward learning: a replication study and meta-analysis. Genes Brain Behav. 2016 06; 15(5):503-13.
COMT Val(158) Met genotype is associated with reward learning: a replication study and meta-analysis.
Autism and antidepressant use in pregnancy. J Pediatr. 2016 07; 174:278.
Autism and antidepressant use in pregnancy.
Liang SH, Chen JM, Normandin MD, Chang JS, Chang GC, Taylor CK, Trapa P, Plummer MS, Para KS, Conn EL, Lopresti-Morrow L, Lanyon LF, Cook JM, Richter KE, Nolan CE, Schachter JB, Janat F, Che Y, Shanmugasundaram V, Lefker BA, Enerson BE, Livni E, Wang L, Guehl NJ, Patnaik D, Wagner FF, Perlis R, Holson EB, Haggarty SJ, El Fakhri G, Kurumbail RG, Vasdev N
Angewandte Chemie (International ed. in English)
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging. Angew Chem Int Ed Engl. 2016 08 08; 55(33):9601-5.
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.
Song J, Bergen SE, Di Florio A, Karlsson R, Charney A, Ruderfer DM, Stahl EA, Chambert KD, Moran JL, Gordon-Smith K, Forty L, Green EK, Jones I, Jones L, Scolnick EM, Sklar P, Smoller JW, Lichtenstein P, Hultman C, Craddock N, Landén M, Smoller JW, Perlis RH, Lee PH, Castro VM, Hoffnagle AG, Sklar P, Stahl EA, Purcell SM, Ruderfer DM, Charney AW, Roussos P, Michele Pato CP, Medeiros H, Sobel J, Craddock N, Jones I, Forty L, Florio AD, Green E, Jones L, Gordon-Smith K, Landen M, Hultman C, Jureus A, Bergen S, McCarroll S, Moran J, Smoller JW, Chambert K, Belliveau RA
Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder. Mol Psychiatry. 2016 09; 21(9):1290-7.
Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder.
Hyde CL, Nagle MW, Tian C, Chen X, Paciga SA, Wendland JR, Tung JY, Hinds DA, Perlis RH, Winslow AR
Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. Nat Genet. 2016 09; 48(9):1031-6.
Identification of 15 genetic loci associated with risk of major depression in individuals of European descent.
Pramipexole in Treatment-Resistant Depression
Natural language processing for characterizing psychopathology
In vitro and in vivo study of simvastatin plus lithium in bipolar depression
Building a Risk Stratification Model for Treatment Resistance in Major Depressive
Patient-Derived Cellular Models of Putative Antidepressants
In utero antidepressant exposures and risk for autism
Genetics of Cardiotoxic Drug Response to Psychiatric Therapy
McCoy TH, Snapper L, Stern TA, Perlis RH
Underreporting of Delirium in Statewide Claims Data: Implications for Clinical Care and Predictive Modeling. Psychosomatics. 2016 Sep-Oct; 57(5):480-8.
Underreporting of Delirium in Statewide Claims Data: Implications for Clinical Care and Predictive Modeling.
McCoy TH, Castro VM, Roberson AM, Snapper LA, Perlis RH
Improving Prediction of Suicide and Accidental Death After Discharge From General Hospitals With Natural Language Processing. JAMA Psychiatry. 2016 Oct 01; 73(10):1064-1071.
Improving Prediction of Suicide and Accidental Death After Discharge From General Hospitals With Natural Language Processing.
Harper DG, Jensen JE, Ravichandran C, Perlis RH, Fava M, Renshaw PF, Iosifescu DV
Tissue Type-Specific Bioenergetic Abnormalities in Adults with Major Depression. Neuropsychopharmacology. 2017 Mar; 42(4):876-885.
Tissue Type-Specific Bioenergetic Abnormalities in Adults with Major Depression.
Rumshisky A, Ghassemi M, Naumann T, Szolovits P, Castro VM, McCoy TH, Perlis RH
Predicting early psychiatric readmission with natural language processing of narrative discharge summaries. Transl Psychiatry. 2016 10 18; 6(10):e921.
Predicting early psychiatric readmission with natural language processing of narrative discharge summaries.
World psychiatry : official journal of the World Psychiatric Association (WPA)
Abandoning personalization to get to precision in the pharmacotherapy of depression. World Psychiatry. 2016 Oct; 15(3):228-235.
Abandoning personalization to get to precision in the pharmacotherapy of depression.
Bernhard RM, Chaponis J, Siburian R, Gallagher P, Ransohoff K, Wikler D, Perlis RH, Greene JD
Social cognitive and affective neuroscience
Variation in the oxytocin receptor gene (OXTR) is associated with differences in moral judgment. Soc Cogn Affect Neurosci. 2016 12; 11(12):1872-1881.
Variation in the oxytocin receptor gene (OXTR) is associated with differences in moral judgment.
Sellgren CM, Sheridan SD, Gracias J, Xuan D, Fu T, Perlis RH
Patient-specific models of microglia-mediated engulfment of synapses and neural progenitors. Mol Psychiatry. 2017 02; 22(2):170-177.
Patient-specific models of microglia-mediated engulfment of synapses and neural progenitors.
Pavlova B, Perlis RH, Mantere O, Sellgren CM, Isometsä E, Mitchell PB, Alda M, Uher R
Prevalence of current anxiety disorders in people with bipolar disorder during euthymia: a meta-analysis. Psychol Med. 2017 Apr; 47(6):1107-1115.
Prevalence of current anxiety disorders in people with bipolar disorder during euthymia: a meta-analysis.
Direk N, Williams S, Smith JA, Ripke S, Air T, Amare AT, Amin N, Baune BT, Bennett DA, Blackwood DHR, Boomsma D, Breen G, Buttenschøn HN, Byrne EM, Børglum AD, Castelao E, Cichon S, Clarke TK, Cornelis MC, Dannlowski U, De Jager PL, Demirkan A, Domenici E, van Duijn CM, Dunn EC, Eriksson JG, Esko T, Faul JD, Ferrucci L, Fornage M, de Geus E, Gill M, Gordon SD, Grabe HJ, van Grootheest G, Hamilton SP, Hartman CA, Heath AC, Hek K, Hofman A, Homuth G, Horn C, Jan Hottenga J, Kardia SLR, Kloiber S, Koenen K, Kutalik Z, Ladwig KH, Lahti J, Levinson DF, Lewis CM, Lewis G, Li QS, Llewellyn DJ, Lucae S, Lunetta KL, MacIntyre DJ, Madden P, Martin NG, McIntosh AM, Metspalu A, Milaneschi Y, Montgomery GW, Mors O, Mosley TH, Murabito JM, Müller-Myhsok B, Nöthen MM, Nyholt DR, O'Donovan MC, Penninx BW, Pergadia ML, Perlis R, Potash JB, Preisig M, Purcell SM, Quiroz JA, Räikkönen K, Rice JP, Rietschel M, Rivera M, Schulze TG, Shi J, Shyn S, Sinnamon GC, Smit JH, Smoller JW, Snieder H, Tanaka T, Tansey KE, Teumer A, Uher R, Umbricht D, Van der Auwera S, Ware EB, Weir DR, Weissman MM, Willemsen G, Yang J, Zhao W, Tiemeier H, Sullivan PF
An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype. Biol Psychiatry. 2017 09 01; 82(5):322-329.
An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype.
Charney AW, Ruderfer DM, Stahl EA, Moran JL, Chambert K, Belliveau RA, Forty L, Gordon-Smith K, Di Florio A, Lee PH, Bromet EJ, Buckley PF, Escamilla MA, Fanous AH, Fochtmann LJ, Lehrer DS, Malaspina D, Marder SR, Morley CP, Nicolini H, Perkins DO, Rakofsky JJ, Rapaport MH, Medeiros H, Sobell JL, Green EK, Backlund L, Bergen SE, Juréus A, Schalling M, Lichtenstein P, Roussos P, Knowles JA, Jones I, Jones LA, Hultman CM, Perlis RH, Purcell SM, McCarroll SA, Pato CN, Pato MT, Craddock N, Landén M, Smoller JW, Sklar P
Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder. Transl Psychiatry. 2017 01 10; 7(1):e993.
Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder.
McCoy TH, Chaukos DC, Snapper LA, Hart KL, Stern TA, Perlis RH
Enhancing Delirium Case Definitions in Electronic Health Records Using Clinical Free Text. Psychosomatics. 2017 Mar - Apr; 58(2):113-120.
Enhancing Delirium Case Definitions in Electronic Health Records Using Clinical Free Text.
García-González J, Tansey KE, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Žagar T, Czerski PM, Jerman B, Buttenschøn HN, Schulze TG, Zobel A, Farmer A, Aitchison KJ, Craig I, McGuffin P, Giupponi M, Perroud N, Bondolfi G, Evans D, O'Donovan M, Peters TJ, Wendland JR, Lewis G, Kapur S, Perlis R, Arolt V, Domschke K, Breen G, Curtis C, Sang-Hyuk L, Kan C, Newhouse S, Patel H, Baune BT, Uher R, Lewis CM, Fabbri C
Progress in neuro-psychopharmacology & biological psychiatry
Pharmacogenetics of antidepressant response: A polygenic approach. Prog Neuropsychopharmacol Biol Psychiatry. 2017 04 03; 75:128-134.
Prog Neuropsychopharmacol Biol Psychiatry
Pharmacogenetics of antidepressant response: A polygenic approach.
Barak-Corren Y, Castro VM, Javitt S, Hoffnagle AG, Dai Y, Perlis RH, Nock MK, Smoller JW, Reis BY
Predicting Suicidal Behavior From Longitudinal Electronic Health Records. Am J Psychiatry. 2017 Feb 01; 174(2):154-162.
Predicting Suicidal Behavior From Longitudinal Electronic Health Records.
McCoy TH, Castro VM, Cagan A, Roberson AM, Perlis RH
Validation of a risk stratification tool for fall-related injury in a state-wide cohort. BMJ Open. 2017 02 06; 7(2):e012189.
Validation of a risk stratification tool for fall-related injury in a state-wide cohort.
Post RM, Baldassano CF, Perlis RH, Ginsberg DL
Treatment of bipolar depression. CNS Spectr. 2003 Dec; 8(12):1-10; quiz 11.
Ongur D, Farabaugh A, Iosifescu DV, Perlis R, Fava M
Tridimensional personality questionnaire factors in major depressive disorder: relationship to anxiety disorder comorbidity and age of onset. Psychother Psychosom. 2005; 74(3):173-8.
Tridimensional personality questionnaire factors in major depressive disorder: relationship to anxiety disorder comorbidity and age of onset.
Papakostas GI, Petersen TJ, Perlis RH, Judy AE, Burns AM, Alpert JE, Birnbaum RJ, Fava M
A survey of antidepressant prescribing practices in major depression with comorbid attention-deficit hyperactivity disorder. J Clin Psychopharmacol. 2006 Apr; 26(2):216-8.
A survey of antidepressant prescribing practices in major depression with comorbid attention-deficit hyperactivity disorder.
Perlis RH, Welge JA, Vornik LA, Hirschfeld RM, Keck PE
Atypical antipsychotics in the treatment of mania: a meta-analysis of randomized, placebo-controlled trials. J Clin Psychiatry. 2006 Apr; 67(4):509-16.
Atypical antipsychotics in the treatment of mania: a meta-analysis of randomized, placebo-controlled trials.
Perlis RH, Alpert J, Nierenberg AA, Mischoulon D, Yeung A, Rosenbaum JF, Fava M
Clinical and sociodemographic predictors of response to augmentation, or dose increase among depressed outpatients resistant to fluoxetine 20 mg/day. Acta Psychiatr Scand. 2003 Dec; 108(6):432-8.
Clinical and sociodemographic predictors of response to augmentation, or dose increase among depressed outpatients resistant to fluoxetine 20 mg/day.
The role of pharmacologic treatment guidelines for bipolar disorder. J Clin Psychiatry. 2005; 66 Suppl 3:37-47.
The role of pharmacologic treatment guidelines for bipolar disorder.
Prevalence and implications of cytochrome P450 substrates in Massachusetts hospital discharges. Pharmacogenomics J. 2017 07; 17(4):382-385.
Prevalence and implications of cytochrome P450 substrates in Massachusetts hospital discharges.
Venkatesh KK, Kaimal AJ, Castro VM, Perlis RH
Improving discrimination in antepartum depression screening using the Edinburgh Postnatal Depression Scale. J Affect Disord. 2017 May; 214:1-7.
Improving discrimination in antepartum depression screening using the Edinburgh Postnatal Depression Scale.
Iosifescu DV, Renshaw PF, Lyoo IK, Lee HK, Perlis RH, Papakostas GI, Nierenberg AA, Fava M
Brain white-matter hyperintensities and treatment outcome in major depressive disorder. Br J Psychiatry. 2006 Feb; 188:180-5.
Brain white-matter hyperintensities and treatment outcome in major depressive disorder.
Stewart SE, Platko J, Fagerness J, Birns J, Jenike E, Smoller JW, Perlis R, Leboyer M, Delorme R, Chabane N, Rauch SL, Jenike MA, Pauls DL
A genetic family-based association study of OLIG2 in obsessive-compulsive disorder. Arch Gen Psychiatry. 2007 Feb; 64(2):209-14.
A genetic family-based association study of OLIG2 in obsessive-compulsive disorder.
Fraguas R, Iosifescu DV, Bankier B, Perlis R, Clementi-Craven N, Alpert J, Fava M
International journal of psychiatry in medicine
Major depressive disorder with anger attacks and cardiovascular risk factors. Int J Psychiatry Med. 2007; 37(1):99-111.
Major depressive disorder with anger attacks and cardiovascular risk factors.
Perlis RH, Fava M, Trivedi MH, Alpert J, Luther JF, Wisniewski SR, Rush AJ
Irritability is associated with anxiety and greater severity, but not bipolar spectrum features, in major depressive disorder. Acta Psychiatr Scand. 2009 Apr; 119(4):282-9.
Irritability is associated with anxiety and greater severity, but not bipolar spectrum features, in major depressive disorder.
Ostacher MJ, Perlis RH, Nierenberg AA, Calabrese J, Stange JP, Salloum I, Weiss RD, Sachs GS
Impact of substance use disorders on recovery from episodes of depression in bipolar disorder patients: prospective data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Am J Psychiatry. 2010 Mar; 167(3):289-97.
Impact of substance use disorders on recovery from episodes of depression in bipolar disorder patients: prospective data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD).
Bigdeli TB, Ripke S, Peterson RE, Trzaskowski M, Bacanu SA, Abdellaoui A, Andlauer TF, Beekman AT, Berger K, Blackwood DH, Boomsma DI, Breen G, Buttenschøn HN, Byrne EM, Cichon S, Clarke TK, Couvy-Duchesne B, Craddock N, de Geus EJ, Degenhardt F, Dunn EC, Edwards AC, Fanous AH, Forstner AJ, Frank J, Gill M, Gordon SD, Grabe HJ, Hamilton SP, Hardiman O, Hayward C, Heath AC, Henders AK, Herms S, Hickie IB, Hoffmann P, Homuth G, Hottenga JJ, Ising M, Jansen R, Kloiber S, Knowles JA, Lang M, Li QS, Lucae S, MacIntyre DJ, Madden PA, Martin NG, McGrath PJ, McGuffin P, McIntosh AM, Medland SE, Mehta D, Middeldorp CM, Milaneschi Y, Montgomery GW, Mors O, Müller-Myhsok B, Nauck M, Nyholt DR, Nöthen MM, Owen MJ, Penninx BW, Pergadia ML, Perlis RH, Peyrot WJ, Porteous DJ, Potash JB, Rice JP, Rietschel M, Riley BP, Rivera M, Schoevers R, Schulze TG, Shi J, Shyn SI, Smit JH, Smoller JW, Streit F, Strohmaier J, Teumer A, Treutlein J, Van der Auwera S, van Grootheest G, van Hemert AM, Völzke H, Webb BT, Weissman MM, Wellmann J, Willemsen G, Witt SH, Levinson DF, Lewis CM, Wray NR, Flint J, Sullivan PF, Kendler KS
Genetic effects influencing risk for major depressive disorder in China and Europe. Transl Psychiatry. 2017 03 28; 7(3):e1074.
Genetic effects influencing risk for major depressive disorder in China and Europe.
Misdiagnosis of bipolar disorder. Am J Manag Care. 2005 Oct; 11(9 Suppl):S271-4.
Iosifescu DV, Nierenberg AA, Alpert JE, Papakostas GI, Perlis RH, Sonawalla S, Fava M
Comorbid medical illness and relapse of major depressive disorder in the continuation phase of treatment. Psychosomatics. 2004 Sep-Oct; 45(5):419-25.
Comorbid medical illness and relapse of major depressive disorder in the continuation phase of treatment.
Ravichandran C, Shinn AK, Öngür D, Perlis RH, Cohen B
Frequency of non-right-handedness in bipolar disorder and schizophrenia. Psychiatry Res. 2017 07; 253:267-269.
Frequency of non-right-handedness in bipolar disorder and schizophrenia.
Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, Sklar P
Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005 Jun 01; 57(11):1313-23.
Molecular genetics of attention-deficit/hyperactivity disorder.
Perlis RH, Ostacher MJ, Goldberg JF, Miklowitz DJ, Friedman E, Calabrese J, Thase ME, Sachs GS
Transition to mania during treatment of bipolar depression. Neuropsychopharmacology. 2010 Dec; 35(13):2545-52.
Transition to mania during treatment of bipolar depression.
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18; 43(10):977-83.
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
Bowden CL, Perlis RH, Thase ME, Ketter TA, Ostacher MM, Calabrese JR, Reilly-Harrington NA, Gonzalez JM, Singh V, Nierenberg AA, Sachs GS
Aims and results of the NIMH systematic treatment enhancement program for bipolar disorder (STEP-BD). CNS Neurosci Ther. 2012 Mar; 18(3):243-9.
Aims and results of the NIMH systematic treatment enhancement program for bipolar disorder (STEP-BD).
Goldberg JF, Perlis RH, Ghaemi SN, Calabrese JR, Bowden CL, Wisniewski S, Miklowitz DJ, Sachs GS, Thase ME
Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD. Am J Psychiatry. 2007 Sep; 164(9):1348-55.
Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD.
Perlis RH, Miyahara S, Marangell LB, Wisniewski SR, Ostacher M, DelBello MP, Bowden CL, Sachs GS, Nierenberg AA
Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biol Psychiatry. 2004 May 01; 55(9):875-81.
Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD).
Clancy TE, Dixon E, Perlis R, Sutherland FR, Zinner MJ
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
Hepatic arterial infusion after curative resection of colorectal cancer metastases: a meta-analysis of prospective clinical trials. J Gastrointest Surg. 2005 Feb; 9(2):198-206.
Hepatic arterial infusion after curative resection of colorectal cancer metastases: a meta-analysis of prospective clinical trials.
Frankle WG, Perlis RH, Deckersbach T, Grandin LD, Gray SM, Sachs GS, Nierenberg AA
Bipolar depression: relationship between episode length and antidepressant treatment. Psychol Med. 2002 Nov; 32(8):1417-23.
Bipolar depression: relationship between episode length and antidepressant treatment.
Perlis RH, Brown E, Baker RW, Nierenberg AA
Clinical features of bipolar depression versus major depressive disorder in large multicenter trials. Am J Psychiatry. 2006 Feb; 163(2):225-31.
Clinical features of bipolar depression versus major depressive disorder in large multicenter trials.
Perlis RH, Fraguas R, Fava M, Trivedi MH, Luther JF, Wisniewski SR, Rush AJ
Prevalence and clinical correlates of irritability in major depressive disorder: a preliminary report from the Sequenced Treatment Alternatives to Relieve Depression study. J Clin Psychiatry. 2005 Feb; 66(2):159-66; quiz 147, 273-4.
Prevalence and clinical correlates of irritability in major depressive disorder: a preliminary report from the Sequenced Treatment Alternatives to Relieve Depression study.
Iosifescu DV, Nierenberg AA, Mischoulon D, Perlis RH, Papakostas GI, Ryan JL, Alpert JE, Fava M
An open study of triiodothyronine augmentation of selective serotonin reuptake inhibitors in treatment-resistant major depressive disorder. J Clin Psychiatry. 2005 Aug; 66(8):1038-42.
An open study of triiodothyronine augmentation of selective serotonin reuptake inhibitors in treatment-resistant major depressive disorder.
Hennen J, Perlis RH, Sachs G, Tohen M, Baldessarini RJ
Weight gain during treatment of bipolar I patients with olanzapine. J Clin Psychiatry. 2004 Dec; 65(12):1679-87.
Weight gain during treatment of bipolar I patients with olanzapine.
Candrian M, Schwartz F, Farabaugh A, Perlis RH, Ehlert U, Fava M
Personality disorders and perceived stress in major depressive disorder. Psychiatry Res. 2008 Aug 15; 160(2):184-91.
Personality disorders and perceived stress in major depressive disorder.
Lipkovich I, Citrome L, Perlis R, Deberdt W, Houston JP, Ahl J, Hardy T
Early predictors of substantial weight gain in bipolar patients treated with olanzapine. J Clin Psychopharmacol. 2006 Jun; 26(3):316-20.
Early predictors of substantial weight gain in bipolar patients treated with olanzapine.
Nierenberg AA, Ostacher MJ, Borrelli DJ, Iosifescu DV, Perlis RH, Desrosiers A, Armistead MS, Calkins AW, Sachs GS
The integration of measurement and management for the treatment of bipolar disorder: a STEP-BD model of collaborative care in psychiatry. J Clin Psychiatry. 2006; 67 Suppl 11:3-7.
The integration of measurement and management for the treatment of bipolar disorder: a STEP-BD model of collaborative care in psychiatry.
Characterizing and predicting rates of delirium across general hospital settings. Gen Hosp Psychiatry. 2017 05; 46:1-6.
Characterizing and predicting rates of delirium across general hospital settings.
Pharmacogenetic studies of antidepressant response: how far from the clinic? Psychiatr Clin North Am. 2007 Mar; 30(1):125-38.
Pharmacogenetic studies of antidepressant response: how far from the clinic?
Perlis RH, Laje G, Smoller JW, Fava M, Rush AJ, McMahon FJ
Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients. Neuropsychopharmacology. 2009 Jun; 34(7):1819-28.
Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients.
McMurrich S, Sylvia LG, Dupuy JM, Peckham AD, Peters AT, Deckersbach T, Perlis RH
Course, outcomes, and psychosocial interventions for first-episode mania. Bipolar Disord. 2012 Dec; 14(8):797-808.
Course, outcomes, and psychosocial interventions for first-episode mania.
Perlis RH, Iosifescu DV, Castro VM, Murphy SN, Gainer VS, Minnier J, Cai T, Goryachev S, Zeng Q, Gallagher PJ, Fava M, Weilburg JB, Churchill SE, Kohane IS, Smoller JW
Using electronic medical records to enable large-scale studies in psychiatry: treatment resistant depression as a model. Psychol Med. 2012 Jan; 42(1):41-50.
Using electronic medical records to enable large-scale studies in psychiatry: treatment resistant depression as a model.
Perlis RH, Iosifescu DV, Alpert J, Nierenberg AA, Rosenbaum JF, Fava M
Effect of medical comorbidity on response to fluoxetine augmentation or dose increase in outpatients with treatment-resistant depression. Psychosomatics. 2004 May-Jun; 45(3):224-9.
Effect of medical comorbidity on response to fluoxetine augmentation or dose increase in outpatients with treatment-resistant depression.
Venkatesh KK, Castro VM, Perlis RH, Kaimal AJ
Journal of perinatology : official journal of the California Perinatal Association
Impact of antidepressant treatment during pregnancy on obstetric outcomes among women previously treated for depression: an observational cohort study. J Perinatol. 2017 09; 37(9):1003-1009.
Impact of antidepressant treatment during pregnancy on obstetric outcomes among women previously treated for depression: an observational cohort study.
McCoy TH, Castro VM, Cagan A, Snapper L, Roberson A, Perlis RH
Cytochrome P450 interactions are common and consequential in Massachusetts hospital discharges. Pharmacogenomics J. 2018 04; 18(2):347-350.
Cytochrome P450 interactions are common and consequential in Massachusetts hospital discharges.
Perlis RH, Baker RW, Zarate CA, Brown EB, Schuh LM, Jamal HH, Tohen M
Olanzapine versus risperidone in the treatment of manic or mixed States in bipolar I disorder: a randomized, double-blind trial. J Clin Psychiatry. 2006 Nov; 67(11):1747-53.
Olanzapine versus risperidone in the treatment of manic or mixed States in bipolar I disorder: a randomized, double-blind trial.
Miller KK, Perlis RH, Papakostas GI, Mischoulon D, Losifescu DV, Brick DJ, Fava M
Low-dose transdermal testosterone augmentation therapy improves depression severity in women. CNS Spectr. 2009 Dec; 14(12):688-94.
Low-dose transdermal testosterone augmentation therapy improves depression severity in women.
Fijal B, Perlis RH, Heinloth AN, Houston JP
The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder. J Pain. 2010 Sep; 11(9):910-5, 915.e1-9.
The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder.
Perlis RH, Purcell S, Fagerness J, Kirby A, Petryshen TL, Fan J, Sklar P
Family-based association study of lithium-related and other candidate genes in bipolar disorder. Arch Gen Psychiatry. 2008 Jan; 65(1):53-61.
Family-based association study of lithium-related and other candidate genes in bipolar disorder.
Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, Fan J, Kirov G, Perlis RH, Green EK, Smoller JW, Grozeva D, Stone J, Nikolov I, Chambert K, Hamshere ML, Nimgaonkar VL, Moskvina V, Thase ME, Caesar S, Sachs GS, Franklin J, Gordon-Smith K, Ardlie KG, Gabriel SB, Fraser C, Blumenstiel B, Defelice M, Breen G, Gill M, Morris DW, Elkin A, Muir WJ, McGhee KA, Williamson R, MacIntyre DJ, MacLean AW, St CD, Robinson M, Van Beck M, Pereira AC, Kandaswamy R, McQuillin A, Collier DA, Bass NJ, Young AH, Lawrence J, Ferrier IN, Anjorin A, Farmer A, Curtis D, Scolnick EM, McGuffin P, Daly MJ, Corvin AP, Holmans PA, Blackwood DH, Gurling HM, Owen MJ, Purcell SM, Sklar P, Craddock N
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet. 2008 Sep; 40(9):1056-8.
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
Perlis RH, Dennehy EB, Miklowitz DJ, Delbello MP, Ostacher M, Calabrese JR, Ametrano RM, Wisniewski SR, Bowden CL, Thase ME, Nierenberg AA, Sachs G
Retrospective age at onset of bipolar disorder and outcome during two-year follow-up: results from the STEP-BD study. Bipolar Disord. 2009 Jun; 11(4):391-400.
Retrospective age at onset of bipolar disorder and outcome during two-year follow-up: results from the STEP-BD study.
Pharmacogenetics studies in STAR*D: strengths, limitations, and results. Psychiatr Serv. 2009 Nov; 60(11):1446-57.
Pharmacogenetics studies in STAR*D: strengths, limitations, and results.
Kane JM, Fleischhacker WW, Hansen L, Perlis R, Pikalov A, Assunção-Talbott S
Akathisia: an updated review focusing on second-generation antipsychotics. J Clin Psychiatry. 2009 Apr 21; 70(5):627-43.
Akathisia: an updated review focusing on second-generation antipsychotics.
Castro VM, Clements CC, Murphy SN, Gainer VS, Fava M, Weilburg JB, Erb JL, Churchill SE, Kohane IS, Iosifescu DV, Smoller JW, Perlis RH
QT interval and antidepressant use: a cross sectional study of electronic health records. BMJ. 2013 Jan 29; 346:f288.
QT interval and antidepressant use: a cross sectional study of electronic health records.
A clinical risk stratification tool for predicting treatment resistance in major depressive disorder. Biol Psychiatry. 2013 Jul 01; 74(1):7-14.
A clinical risk stratification tool for predicting treatment resistance in major depressive disorder.
McCoy TH, Castro VM, Snapper LA, Hart KL, Perlis RH
Efficient genome-wide association in biobanks using topic modeling identifies multiple novel disease loci. Mol Med. 2017 11; 23:285-294.
Efficient genome-wide association in biobanks using topic modeling identifies multiple novel disease loci.
Liu Y, Blackwood DH, Caesar S, de Geus EJ, Farmer A, Ferreira MA, Ferrier IN, Fraser C, Gordon-Smith K, Green EK, Grozeva D, Gurling HM, Hamshere ML, Heutink P, Holmans PA, Hoogendijk WJ, Hottenga JJ, Jones L, Jones IR, Kirov G, Lin D, McGuffin P, Moskvina V, Nolen WA, Perlis RH, Posthuma D, Scolnick EM, Smit AB, Smit JH, Smoller JW, St Clair D, van Dyck R, Verhage M, Willemsen G, Young AH, Zandbelt T, Boomsma DI, Craddock N, O'Donovan MC, Owen MJ, Penninx BW, Purcell S, Sklar P, Sullivan PF
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Mol Psychiatry. 2011 Jan; 16(1):2-4.
Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
Kim BW, Kennedy DN, Lehár J, Lee MJ, Blood AJ, Lee S, Perlis RH, Smoller JW, Morris R, Fava M, Breiter HC
Recurrent, robust and scalable patterns underlie human approach and avoidance. PLoS One. 2010 May 26; 5(5):e10613.
Recurrent, robust and scalable patterns underlie human approach and avoidance.
Neuroscience and clinical practice: applying pharmacogenomics in psychiatry. Psychiatry (Edgmont). 2006 Nov; 3(11):39-41.
Neuroscience and clinical practice: applying pharmacogenomics in psychiatry.
Extent and impact of industry sponsorship conflicts of interest in dermatology research. J Am Acad Dermatol. 2005 Jun; 52(6):967-71.
Extent and impact of industry sponsorship conflicts of interest in dermatology research.
The development of new antidepressants: focus on duloxetine and escitalopram. Harv Rev Psychiatry. 2003 Jan-Feb; 11(1):30-6.
The development of new antidepressants: focus on duloxetine and escitalopram.
Depression Clinical & Research, WACC 812
McCoy TH, Castro VM, Snapper L, Hart K, Januzzi JL, Huffman JC, Perlis RH
Polygenic loading for major depression is associated with specific medical comorbidity. Transl Psychiatry. 2017 09 19; 7(9):e1238.
Polygenic loading for major depression is associated with specific medical comorbidity.
Clinical insights into pharmacogenetics and schizophrenia, part 2. J Clin Psychiatry. 2008 Jun; 69(6):1006-13.
Clinical insights into pharmacogenetics and schizophrenia, part 2.
Casamassima F, Lattanzi L, Perlis RH, Fratta S, Litta A, Longobardi A, Stange JP, Tatulli A, Cassano GB
Efficacy of electroconvulsive therapy in Fahr disease associated with bipolar psychotic disorder: a case report. J ECT. 2009 Sep; 25(3):213-5.
Efficacy of electroconvulsive therapy in Fahr disease associated with bipolar psychotic disorder: a case report.
Effective agents in treating mania. J Clin Psychiatry. 2009 Apr; 70(4):e08.
Perlis RH, Smoller JW, Mysore J, Sun M, Gillis T, Purcell S, Rietschel M, Nöthen MM, Witt S, Maier W, Iosifescu DV, Sullivan P, Rush AJ, Fava M, Breiter H, Macdonald M, Gusella J
Prevalence of incompletely penetrant Huntington's disease alleles among individuals with major depressive disorder. Am J Psychiatry. 2010 May; 167(5):574-9.
Prevalence of incompletely penetrant Huntington's disease alleles among individuals with major depressive disorder.
Review: mood stabilisers monotherapy as effective as combination therapy for treatment of acute bipolar depression in studies with some limitations. Evid Based Ment Health. 2010 Nov; 13(4):127.
Review: mood stabilisers monotherapy as effective as combination therapy for treatment of acute bipolar depression in studies with some limitations.
Perlis RH, Fijal B, Dharia S, Houston JP
Pharmacogenetic investigation of response to duloxetine treatment in generalized anxiety disorder. Pharmacogenomics J. 2013 Jun; 13(3):280-5.
Pharmacogenetic investigation of response to duloxetine treatment in generalized anxiety disorder.
Ripke S, Wray NR, Lewis CM, Hamilton SP, Weissman MM, Breen G, Byrne EM, Blackwood DH, Boomsma DI, Cichon S, Heath AC, Holsboer F, Lucae S, Madden PA, Martin NG, McGuffin P, Muglia P, Noethen MM, Penninx BP, Pergadia ML, Potash JB, Rietschel M, Lin D, Müller-Myhsok B, Shi J, Steinberg S, Grabe HJ, Lichtenstein P, Magnusson P, Perlis RH, Preisig M, Smoller JW, Stefansson K, Uher R, Kutalik Z, Tansey KE, Teumer A, Viktorin A, Barnes MR, Bettecken T, Binder EB, Breuer R, Castro VM, Churchill SE, Coryell WH, Craddock N, Craig IW, Czamara D, De Geus EJ, Degenhardt F, Farmer AE, Fava M, Frank J, Gainer VS, Gallagher PJ, Gordon SD, Goryachev S, Gross M, Guipponi M, Henders AK, Herms S, Hickie IB, Hoefels S, Hoogendijk W, Hottenga JJ, Iosifescu DV, Ising M, Jones I, Jones L, Jung-Ying T, Knowles JA, Kohane IS, Kohli MA, Korszun A, Landen M, Lawson WB, Lewis G, Macintyre D, Maier W, Mattheisen M, McGrath PJ, McIntosh A, McLean A, Middeldorp CM, Middleton L, Montgomery GM, Murphy SN, Nauck M, Nolen WA, Nyholt DR, O'Donovan M, Oskarsson H, Pedersen N, Scheftner WA, Schulz A, Schulze TG, Shyn SI, Sigurdsson E, Slager SL, Smit JH, Stefansson H, Steffens M, Thorgeirsson T, Tozzi F, Treutlein J, Uhr M, van den Oord EJ, Van Grootheest G, Völzke H, Weilburg JB, Willemsen G, Zitman FG, Neale B, Daly M, Levinson DF, Sullivan PF
A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013 Apr; 18(4):497-511.
A mega-analysis of genome-wide association studies for major depressive disorder.
Hoogenboom WS, Perlis RH, Smoller JW, Zeng-Treitler Q, Gainer VS, Murphy SN, Churchill SE, Kohane IS, Shenton ME, Iosifescu DV
Feasibility of studying brain morphology in major depressive disorder with structural magnetic resonance imaging and clinical data from the electronic medical record: a pilot study. Psychiatry Res. 2013 Mar 30; 211(3):202-13.
Feasibility of studying brain morphology in major depressive disorder with structural magnetic resonance imaging and clinical data from the electronic medical record: a pilot study.
Rosenberg MA, Lubitz SA, Lin H, Kosova G, Castro VM, Huang P, Ellinor PT, Perlis RH, Newton-Cheh C
Validation of Polygenic Scores for QT Interval in Clinical Populations. Circ Cardiovasc Genet. 2017 Oct; 10(5).
Validation of Polygenic Scores for QT Interval in Clinical Populations.
Perlis RH, Sachs GS, Lafer B, Otto MW, Faraone SV, Kane JM, Rosenbaum JF
Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance data. Am J Psychiatry. 2002 Jul; 159(7):1155-9.
Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance data.
Simon NM, Smoller JW, Fava M, Sachs G, Racette SR, Perlis R, Sonawalla S, Rosenbaum JF
Comparing anxiety disorders and anxiety-related traits in bipolar disorder and unipolar depression. J Psychiatr Res. 2003 May-Jun; 37(3):187-92.
Comparing anxiety disorders and anxiety-related traits in bipolar disorder and unipolar depression.
The Texas implementation of medication algorithms update for treatment of bipolar I disorder. J Clin Psychiatry. 2005 Jul; 66(7):818-20.
The Texas implementation of medication algorithms update for treatment of bipolar I disorder.
Cognitive behavioural therapy has short term but not long term benefits in people with residual symptoms of depression. Evid Based Ment Health. 2005 Aug; 8(3):75.
Cognitive behavioural therapy has short term but not long term benefits in people with residual symptoms of depression.
Perlis CS, Campbell RM, Perlis RH, Malik M, Dufresne RG
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
Incidence of and risk factors for medical malpractice lawsuits among Mohs surgeons. Dermatol Surg. 2006 Jan; 32(1):79-83.
Incidence of and risk factors for medical malpractice lawsuits among Mohs surgeons.
Papakostas GI, Perlis RH, Scalia MJ, Petersen TJ, Fava M
A meta-analysis of early sustained response rates between antidepressants and placebo for the treatment of major depressive disorder. J Clin Psychopharmacol. 2006 Feb; 26(1):56-60.
A meta-analysis of early sustained response rates between antidepressants and placebo for the treatment of major depressive disorder.
Marangell LB, Bauer MS, Dennehy EB, Wisniewski SR, Allen MH, Miklowitz DJ, Oquendo MA, Frank E, Perlis RH, Martinez JM, Fagiolini A, Otto MW, Chessick CA, Zboyan HA, Miyahara S, Sachs G, Thase ME
Prospective predictors of suicide and suicide attempts in 1,556 patients with bipolar disorders followed for up to 2 years. Bipolar Disord. 2006 Oct; 8(5 Pt 2):566-75.
Prospective predictors of suicide and suicide attempts in 1,556 patients with bipolar disorders followed for up to 2 years.
Cusin C, Fava M, Amsterdam JD, Quitkin FM, Reimherr FW, Beasley CM, Rosenbaum JF, Perlis RH
Early symptomatic worsening during treatment with fluoxetine in major depressive disorder: prevalence and implications. J Clin Psychiatry. 2007 Jan; 68(1):52-7.
Early symptomatic worsening during treatment with fluoxetine in major depressive disorder: prevalence and implications.
Papakostas GI, Perlis RH, Seifert C, Fava M
Antidepressant dose reduction and the risk of relapse in major depressive disorder. Psychother Psychosom. 2007; 76(5):266-70.
Antidepressant dose reduction and the risk of relapse in major depressive disorder.
Perlis RH, Fava M, Nierenberg AA, Pollack MH, Falk WE, Kienke AS, Rosenbaum JF
Strategies for treatment of SSRI-associated sexual dysfunction: a survey of an academic psychopharmacology practice. Harv Rev Psychiatry. 2002 Mar-Apr; 10(2):109-14.
Strategies for treatment of SSRI-associated sexual dysfunction: a survey of an academic psychopharmacology practice.
Worthington JJ, Simon NM, Korbly NB, Perlis RH, Pollack MH
International clinical psychopharmacology
Ropinirole for antidepressant-induced sexual dysfunction. Int Clin Psychopharmacol. 2002 Nov; 17(6):307-10.
Ropinirole for antidepressant-induced sexual dysfunction.
Corya SA, Perlis RH, Keck PE, Lin DY, Case MG, Williamson DJ, Tohen MF
A 24-week open-label extension study of olanzapine-fluoxetine combination and olanzapine monotherapy in the treatment of bipolar depression. J Clin Psychiatry. 2006 May; 67(5):798-806.
A 24-week open-label extension study of olanzapine-fluoxetine combination and olanzapine monotherapy in the treatment of bipolar depression.
Perlis RH, Moorjani P, Fagerness J, Purcell S, Trivedi MH, Fava M, Rush AJ, Smoller JW
Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR(*)D study. Neuropsychopharmacology. 2008 Nov; 33(12):2810-9.
Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR(*)D study.
Nierenberg AA, Ostacher MJ, Huffman JC, Ametrano RM, Fava M, Perlis RH
Journal of occupational and environmental medicine
A brief review of antidepressant efficacy, effectiveness, indications, and usage for major depressive disorder. J Occup Environ Med. 2008 Apr; 50(4):428-36.
A brief review of antidepressant efficacy, effectiveness, indications, and usage for major depressive disorder.
Pizzagalli DA, Goetz E, Ostacher M, Iosifescu DV, Perlis RH
Euthymic patients with bipolar disorder show decreased reward learning in a probabilistic reward task. Biol Psychiatry. 2008 Jul 15; 64(2):162-8.
Euthymic patients with bipolar disorder show decreased reward learning in a probabilistic reward task.
A roadmap to key pharmacologic principles in using antipsychotics in the treatment of bipolar disorder. J Clin Psychiatry. 2008 Jul; 69(7):1176-83.
A roadmap to key pharmacologic principles in using antipsychotics in the treatment of bipolar disorder.
Uher R, Perlis RH, Henigsberg N, Zobel A, Rietschel M, Mors O, Hauser J, Dernovsek MZ, Souery D, Bajs M, Maier W, Aitchison KJ, Farmer A, McGuffin P
Depression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence for interest-activity symptoms. Psychol Med. 2012 May; 42(5):967-80.
Depression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence for interest-activity symptoms.
Lee PH, Perlis RH, Jung JY, Byrne EM, Rueckert E, Siburian R, Haddad S, Mayerfeld CE, Heath AC, Pergadia ML, Madden PA, Boomsma DI, Penninx BW, Sklar P, Martin NG, Wray NR, Purcell SM, Smoller JW
Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder. Transl Psychiatry. 2012 Nov 13; 2:e184.
Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder.
Ananthakrishnan AN, Gainer VS, Cai T, Perez RG, Cheng SC, Savova G, Chen P, Szolovits P, Xia Z, De Jager PL, Shaw S, Churchill S, Karlson EW, Kohane I, Perlis RH, Plenge RM, Murphy SN, Liao KP
The American journal of gastroenterology
Similar risk of depression and anxiety following surgery or hospitalization for Crohn's disease and ulcerative colitis. Am J Gastroenterol. 2013 Apr; 108(4):594-601.
Similar risk of depression and anxiety following surgery or hospitalization for Crohn's disease and ulcerative colitis.
Perlis RH, Nierenberg AA, Alpert JE, Pava J, Matthews JD, Buchin J, Sickinger AH, Fava M
Effects of adding cognitive therapy to fluoxetine dose increase on risk of relapse and residual depressive symptoms in continuation treatment of major depressive disorder. J Clin Psychopharmacol. 2002 Oct; 22(5):474-80.
Effects of adding cognitive therapy to fluoxetine dose increase on risk of relapse and residual depressive symptoms in continuation treatment of major depressive disorder.
Fabbri C, Tansey KE, Perlis RH, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Breen G, Curtis C, Sang-Hyuk L, Newhouse S, Patel H, Guipponi M, Perroud N, Bondolfi G, O'Donovan M, Lewis G, Biernacka JM, Weinshilboum RM, Farmer A, Aitchison KJ, Craig I, McGuffin P, Uher R, Lewis CM
New insights into the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation. Pharmacogenomics J. 2018 05 22; 18(3):413-421.
New insights into the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation.
Perlis RH, Delbello MP, Miyahara S, Wisniewski SR, Sachs GS, Nierenberg AA
Revisiting depressive-prone bipolar disorder: polarity of initial mood episode and disease course among bipolar I systematic treatment enhancement program for bipolar disorder participants. Biol Psychiatry. 2005 Oct 01; 58(7):549-53.
Revisiting depressive-prone bipolar disorder: polarity of initial mood episode and disease course among bipolar I systematic treatment enhancement program for bipolar disorder participants.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
Limbic system white matter microstructure and long-term treatment outcome in major depressive disorder: a diffusion tensor imaging study using legacy data. World J Biol Psychiatry. 2014 Feb; 15(2):122-34.
Limbic system white matter microstructure and long-term treatment outcome in major depressive disorder: a diffusion tensor imaging study using legacy data.
Uher R, Perlis RH, Placentino A, Dernovšek MZ, Henigsberg N, Mors O, Maier W, McGuffin P, Farmer A
Self-report and clinician-rated measures of depression severity: can one replace the other? Depress Anxiety. 2012 Dec; 29(12):1043-9.
Self-report and clinician-rated measures of depression severity: can one replace the other?
Perlis RH, Ruderfer D, Maussion G, Chambert K, Gallagher P, Turecki G, Ernst C
Bipolar disorder and a history of suicide attempts with a duplication in 5HTR1A. Am J Psychiatry. 2012 Nov; 169(11):1213-4.
Bipolar disorder and a history of suicide attempts with a duplication in 5HTR1A.
Cytochrome P450 genotyping and antidepressants. BMJ. 2007 Apr 14; 334(7597):759.
Cytochrome P450 genotyping and antidepressants.
Perlis RH, Purcell S, Fava M, Fagerness J, Rush AJ, Trivedi MH, Smoller JW
Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study. Arch Gen Psychiatry. 2007 Jun; 64(6):689-97.
Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study.
Pharmacogenomic strategy for individualizing antidepressant therapy. Dialogues Clin Neurosci. 2008; 10(4):401-8.
Pharmacogenomic strategy for individualizing antidepressant therapy.
Can single genes matter in a polygenic world? Biol Psychiatry. 2010 Nov 01; 68(9):783-4.
Can single genes matter in a polygenic world?
Perlis RH, Uher R, Ostacher M, Goldberg JF, Trivedi MH, Rush AJ, Fava M
Association between bipolar spectrum features and treatment outcomes in outpatients with major depressive disorder. Arch Gen Psychiatry. 2011 Apr; 68(4):351-60.
Association between bipolar spectrum features and treatment outcomes in outpatients with major depressive disorder.
Translating biomarkers to clinical practice. Mol Psychiatry. 2011 Nov; 16(11):1076-87.
Translating biomarkers to clinical practice.
Dennehy EB, Bauer MS, Perlis RH, Kogan JN, Sachs GS
Concordance with treatment guidelines for bipolar disorder: data from the systematic treatment enhancement program for bipolar disorder. Psychopharmacol Bull. 2007; 40(3):72-84.
Concordance with treatment guidelines for bipolar disorder: data from the systematic treatment enhancement program for bipolar disorder.
Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB, Faraone SV, Kirby A, de Bakker PI, Ogdie MN, Thase ME, Sachs GS, Todd-Brown K, Gabriel SB, Sougnez C, Gates C, Blumenstiel B, Defelice M, Ardlie KG, Franklin J, Muir WJ, McGhee KA, MacIntyre DJ, McLean A, VanBeck M, McQuillin A, Bass NJ, Robinson M, Lawrence J, Anjorin A, Curtis D, Scolnick EM, Daly MJ, Blackwood DH, Gurling HM, Purcell SM
Whole-genome association study of bipolar disorder. Mol Psychiatry. 2008 Jun; 13(6):558-69.
Whole-genome association study of bipolar disorder.
Petersen T, Perlis RH, Ticknor C, Lohr J, Solvason HB, O'Reardon JP, Wohlreich MM, Andreotti C, Wilson M, Fava M
Efficacy of duloxetine for the treatment of depression: relationship to most recent antidepressant trial. Psychopharmacol Bull. 2008; 41(1):34-45.
Efficacy of duloxetine for the treatment of depression: relationship to most recent antidepressant trial.
Perlis RH, Holt DJ, Smoller JW, Blood AJ, Lee S, Kim BW, Lee MJ, Sun M, Makris N, Kennedy DK, Rooney K, Dougherty DD, Hoge R, Rosenbaum JF, Fava M, Gusella J, Gasic GP, Breiter HC
Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants. Arch Gen Psychiatry. 2008 Aug; 65(8):882-92.
Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants.
Gasic GP, Smoller JW, Perlis RH, Sun M, Lee S, Kim BW, Lee MJ, Holt DJ, Blood AJ, Makris N, Kennedy DK, Hoge RD, Calhoun J, Fava M, Gusella JF, Breiter HC
BDNF, relative preference, and reward circuitry responses to emotional communication. Am J Med Genet B Neuropsychiatr Genet. 2009 Sep 05; 150B(6):762-81.
BDNF, relative preference, and reward circuitry responses to emotional communication.
Ostacher MJ, Lebeau RT, Perlis RH, Nierenberg AA, Lund HG, Moshier SJ, Sachs GS, Simon NM
Cigarette smoking is associated with suicidality in bipolar disorder. Bipolar Disord. 2009 Nov; 11(7):766-71.
Cigarette smoking is associated with suicidality in bipolar disorder.
Perlis RH, Ostacher MJ, Miklowitz DJ, Smoller JW, Dennehy EB, Cowperthwait C, Nierenberg AA, Thase ME, Sachs GS
Benzodiazepine use and risk of recurrence in bipolar disorder: a STEP-BD report. J Clin Psychiatry. 2010 Feb; 71(2):194-200.
Benzodiazepine use and risk of recurrence in bipolar disorder: a STEP-BD report.
Bogdan R, Santesso DL, Fagerness J, Perlis RH, Pizzagalli DA
The Journal of neuroscience : the official journal of the Society for Neuroscience
Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning. J Neurosci. 2011 Sep 14; 31(37):13246-54.
Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning.
Hard outcomes: clinical trials to reduce suicide. Am J Psychiatry. 2011 Oct; 168(10):1009-11.
Hard outcomes: clinical trials to reduce suicide.
Goldberg JF, Brooks JO, Kurita K, Hoblyn JC, Ghaemi SN, Perlis RH, Miklowitz DJ, Ketter TA, Sachs GS, Thase ME
Depressive illness burden associated with complex polypharmacy in patients with bipolar disorder: findings from the STEP-BD. J Clin Psychiatry. 2009 Feb; 70(2):155-62.
Depressive illness burden associated with complex polypharmacy in patients with bipolar disorder: findings from the STEP-BD.
Reilly-Harrington NA, DeBonis D, Leon AC, Sylvia L, Perlis R, Lewis D, Sachs GS
The interactive computer interview for mania. Bipolar Disord. 2010 Aug; 12(5):521-7.
The interactive computer interview for mania.
Makris N, Gasic GP, Kennedy DN, Hodge SM, Kaiser JR, Lee MJ, Kim BW, Blood AJ, Evins AE, Seidman LJ, Iosifescu DV, Lee S, Baxter C, Perlis RH, Smoller JW, Fava M, Breiter HC
Cortical thickness abnormalities in cocaine addiction--a reflection of both drug use and a pre-existing disposition to drug abuse? Neuron. 2008 Oct 09; 60(1):174-88.
Cortical thickness abnormalities in cocaine addiction--a reflection of both drug use and a pre-existing disposition to drug abuse?
Perlis RH, Ostacher MJ, Uher R, Nierenberg AA, Casamassima F, Kansky C, Calabrese JR, Thase M, Sachs GS
Stability of symptoms across major depressive episodes in bipolar disorder. Bipolar Disord. 2009 Dec; 11(8):867-75.
Stability of symptoms across major depressive episodes in bipolar disorder.
Bogdan R, Perlis RH, Fagerness J, Pizzagalli DA
The impact of mineralocorticoid receptor ISO/VAL genotype (rs5522) and stress on reward learning. Genes Brain Behav. 2010 Aug; 9(6):658-67.
The impact of mineralocorticoid receptor ISO/VAL genotype (rs5522) and stress on reward learning.
Barnett JH, Huang J, Perlis RH, Young MM, Rosenbaum JF, Nierenberg AA, Sachs G, Nimgaonkar VL, Miklowitz DJ, Smoller JW
Personality and bipolar disorder: dissecting state and trait associations between mood and personality. Psychol Med. 2011 Aug; 41(8):1593-604.
Personality and bipolar disorder: dissecting state and trait associations between mood and personality.
Ananthakrishnan AN, Gainer VS, Perez RG, Cai T, Cheng SC, Savova G, Chen P, Szolovits P, Xia Z, De Jager PL, Shaw SY, Churchill S, Karlson EW, Kohane I, Perlis RH, Plenge RM, Murphy SN, Liao KP
Psychiatric co-morbidity is associated with increased risk of surgery in Crohn's disease. Aliment Pharmacol Ther. 2013 Feb; 37(4):445-54.
Psychiatric co-morbidity is associated with increased risk of surgery in Crohn's disease.
Fass DM, Schroeder FA, Perlis RH, Haggarty SJ
Epigenetic mechanisms in mood disorders: targeting neuroplasticity. Neuroscience. 2014 Apr 04; 264:112-30.
Epigenetic mechanisms in mood disorders: targeting neuroplasticity.
Perlis RH, Smoller JW, Fava M, Rosenbaum JF, Nierenberg AA, Sachs GS
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