My research concentrates on the major public health problem of sudden cardiac death, which claims approximately 325,000 lives per year in the United States alone and occurs without prodromes in at least 30% of cases. The main challenges have been to elucidate the complex pathophysiologic factors involved and to develop novel approaches for identifying individuals at risk for this mode of demise. In an extensive series of studies, my colleagues and I explored the mechanisms responsible for sudden arrhythmic death. Our investigations demonstrated the pivotal role played by sympathetic nerve activity in triggering life-threatening arrhythmias and defined contributions of beta-adrenergic receptors acting primarily on intracellular calcium handling. We also determined that vagus nerve activity opposes the deleterious influence of adrenergic activity by opposition to presynaptic release of norepinephrine and direct antagonism of second messenger effects. I developed an experimental model in canines that emulated the angerlike state and allowed us to demonstrate that intense behavioral arousal profoundly alters cardiac electrical instability and coronary reactivity, which in turn predispose to malignant arrhythmias. My group and I also systematically studied the impact of sleep states on coronary hemodynamic and cardiac electrophysiologic function. The knowledge base generated was published in Science, Circulation, New England Journal of Medicine, and other leading journals. My basic science studies on neural control of heart rhythm received NIH funding for more than 35 years. My most significant contributions to clinical innovation emerged during my appointment at Harvard Medical School in Beth Israel Deaconess Medical Center’s Division of Cardiovascular Medicine. In collaboration with my junior colleague, Dr. Bruce D. Nearing, a biomedical engineer, I discovered and published in Science in 1991 evidence that a fundamental electrophysiologic phenomenon, “T-wave alternans,” a beat-to-beat fluctuation in the magnitude of this waveform, is capable of stratifying risk for life-threatening arrhythmia. An extensive series of experiments revealed that T-wave alternans is tracks effects of neural factors, myocardial ischemia, and other proarrhythmic influences. Conversely, antiarrhythmic physiologic and pharmacologic interventions reduce the magnitude of alternans. These findings provided essential scientific underpinnings for utilizing alternans as a clinical marker of arrhythmic risk and target for therapeutic interventions. We developed, patented, and implemented methodologies for quantifying alternans that are compatible with routine ambulatory ECG monitoring and exercise stress testing and employed them to demonstrate that this phenomenon is capable of assessing risk for arrhythmic events in >1,600 post-myocardial infarction and heart failure patients based on ambulatory ECGs recordings. Prediction was also demonstrated in >3,500 consecutive patients with preserved left ventricular function who were referred for routine exercise testing. In 2011, I was lead author of a clinical consensus guideline on T-wave alternans by international experts that was published in Journal of the American College of Cardiology. In summary, my research program focuses on sudden cardiac death, with dual emphasis on elucidation of pathophysiologic mechanisms and translation from bench to bedside. Our patented, FDA-approved diagnostic risk assessment technology is now in use in clinics and hospitals worldwide.
Corresponding Member of the Faculty of Medicine
Intrapericardial beta-adrenergic blockade with esmolol exerts a potent antitachycardic effect without depressing contractility. J Cardiovasc Pharmacol. 2000 Dec; 36(6):722-7.
Intrapericardial beta-adrenergic blockade with esmolol exerts a potent antitachycardic effect without depressing contractility.
Journal of the American College of Cardiology
Angerlike behavioral state potentiates myocardial ischemia-induced T-wave alternans in canines. J Am Coll Cardiol. 2001 May; 37(6):1719-25.
Angerlike behavioral state potentiates myocardial ischemia-induced T-wave alternans in canines.
Italian heart journal : official journal of the Italian Federation of Cardiology
How to search for the predisposing role of psychological distress and its prevalence. Introduction. Ital Heart J. 2001 Dec; 2(12):885-6.
How to search for the predisposing role of psychological distress and its prevalence. Introduction.
Kenttä TV, Sinner MF, Nearing BD, Freudling R, Porthan K, Tikkanen JT, Müller-Nurasyid M, Schramm K, Viitasalo M, Jula A, Nieminen MS, Peters A, Salomaa V, Oikarinen L, Verrier RL, Kääb S, Junttila MJ, Huikuri HV
Circulation. Arrhythmia and electrophysiology
Repolarization Heterogeneity Measured With T-Wave Area Dispersion in Standard 12-Lead ECG Predicts Sudden Cardiac Death in General Population. Circ Arrhythm Electrophysiol. 2018 02; 11(2):e005762.
Repolarization Heterogeneity Measured With T-Wave Area Dispersion in Standard 12-Lead ECG Predicts Sudden Cardiac Death in General Population.
Takasugi N, Takasugi M, Goto H, Kuwahara T, Nakashima T, Kubota T, Kanamori H, Kawasaki M, Nishigaki K, Minatoguchi S, Verrier RL
Significance of T-wave inversion triggered by spontaneous atrial premature beats in patients with long QT syndrome. Heart Rhythm. 2018 06; 15(6):860-869.
Significance of T-wave inversion triggered by spontaneous atrial premature beats in patients with long QT syndrome.
Clarke RW, Coull B, Reinisch U, Catalano P, Killingsworth CR, Koutrakis P, Kavouras I, Murthy GG, Lawrence J, Lovett E, Wolfson JM, Verrier RL, Godleski JJ
Inhaled concentrated ambient particles are associated with hematologic and bronchoalveolar lavage changes in canines. Environ Health Perspect. 2000 Dec; 108(12):1179-87.
Inhaled concentrated ambient particles are associated with hematologic and bronchoalveolar lavage changes in canines.
Effect of alpha-adrenergic receptor stimulation on ventricular electrical properties in the normal canine heart. Am Heart J. 1983 Mar; 105(3):366-71.
Effect of alpha-adrenergic receptor stimulation on ventricular electrical properties in the normal canine heart.
Autonomic aspects of arrhythmogenesis: the enduring and the new. Curr Opin Cardiol. 2004 Jan; 19(1):2-11.
Autonomic aspects of arrhythmogenesis: the enduring and the new.
Wellenius GA, Batalha JR, Diaz EA, Lawrence J, Coull BA, Katz T, Verrier RL, Godleski JJ
Toxicological sciences : an official journal of the Society of Toxicology
Cardiac effects of carbon monoxide and ambient particles in a rat model of myocardial infarction. Toxicol Sci. 2004 Aug; 80(2):367-76.
Cardiac effects of carbon monoxide and ambient particles in a rat model of myocardial infarction.
Effect of acute blood pressure elevation on the ventricular fibrillation threshold. Am J Physiol. 1974 Apr; 226(4):893-7.
Effect of acute blood pressure elevation on the ventricular fibrillation threshold.
Cardiac performance in experimental adrenal insufficiency in cats. Circ Res. 1968 Jun; 22(6):817-27.
Cardiac performance in experimental adrenal insufficiency in cats.
Precordial mechanical stimulation for exposing electrical instability in the ischemic heart. Am J Cardiol. 1978 Sep; 42(3):425-8.
Precordial mechanical stimulation for exposing electrical instability in the ischemic heart.
Protective effect of verapamil on vulnerability to ventricular fibrillation during myocardial ischaemia and reperfusion. Cardiovasc Res. 1980 May; 14(5):295-302.
Protective effect of verapamil on vulnerability to ventricular fibrillation during myocardial ischaemia and reperfusion.
Peters A, Liu E, Verrier RL, Schwartz J, Gold DR, Mittleman M, Baliff J, Oh JA, Allen G, Monahan K, Dockery DW
Air pollution and incidence of cardiac arrhythmia. Epidemiology. 2000 Jan; 11(1):11-7.
Air pollution and incidence of cardiac arrhythmia.
Current treatment options in cardiovascular medicine
Treatment options for patients with coronary artery disease identified as high risk by T-wave alternans testing. Curr Treat Options Cardiovasc Med. 2008 Feb; 10(1):39-48.
Treatment options for patients with coronary artery disease identified as high risk by T-wave alternans testing.
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
Usefulness of T-wave alternans in sudden death risk stratification and guiding medical therapy. Ann Noninvasive Electrocardiol. 2010 Jul; 15(3):276-88.
Usefulness of T-wave alternans in sudden death risk stratification and guiding medical therapy.
Basis for sudden cardiac death prediction by T-wave alternans from an integrative physiology perspective. Heart Rhythm. 2009 Mar; 6(3):416-22.
Basis for sudden cardiac death prediction by T-wave alternans from an integrative physiology perspective.
Kumar K, Nearing BD, Carvas M, Nascimento BC, Acar M, Belardinelli L, Verrier RL
Journal of cardiovascular electrophysiology
Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart. J Cardiovasc Electrophysiol. 2009 Jul; 20(7):796-802.
Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart.
Ventricular vulnerability during sympathetic stimulation: role of heart rate and blood pressure. Cardiovasc Res. 1974 Sep; 8(5):602-10.
Ventricular vulnerability during sympathetic stimulation: role of heart rate and blood pressure.
Influence of the autonomic nervous system on coronary blood flow during partial stenosis. Am Heart J. 1982 Aug; 104(2 Pt 1):249-53.
Influence of the autonomic nervous system on coronary blood flow during partial stenosis.
Ivabradine's Pleiotropic Profile: Can It Protect Against Doxorubicin-Induced Heart Failure? J Cardiovasc Pharmacol. 2018 07; 72(1):19-21.
Ivabradine's Pleiotropic Profile: Can It Protect Against Doxorubicin-Induced Heart Failure?
The frustrating search for arrhythmia risk stratifiers in heart failure due to nonischemic cardiomyopathy: does T-wave alternans testing help? J Am Coll Cardiol. 2007 Nov 06; 50(19):1905-6.
The frustrating search for arrhythmia risk stratifiers in heart failure due to nonischemic cardiomyopathy: does T-wave alternans testing help?
Kumar K, Nearing BD, Bartoli CR, Kwaku KF, Belardinelli L, Verrier RL
Effect of ranolazine on ventricular vulnerability and defibrillation threshold in the intact porcine heart. J Cardiovasc Electrophysiol. 2008 Oct; 19(10):1073-9.
Effect of ranolazine on ventricular vulnerability and defibrillation threshold in the intact porcine heart.
Minkkinen M, Kähönen M, Viik J, Nikus K, Lehtimäki T, Lehtinen R, Kööbi T, Turjanmaa V, Kaiser W, Verrier RL, Nieminen T
Enhanced predictive power of quantitative TWA during routine exercise testing in the Finnish Cardiovascular Study. J Cardiovasc Electrophysiol. 2009 Apr; 20(4):408-15.
Enhanced predictive power of quantitative TWA during routine exercise testing in the Finnish Cardiovascular Study.
Nearing BD, Wellenius GA, Mittleman MA, Josephson ME, Burger AJ, Verrier RL
Crescendo in depolarization and repolarization heterogeneity heralds development of ventricular tachycardia in hospitalized patients with decompensated heart failure. Circ Arrhythm Electrophysiol. 2012 Feb; 5(1):84-90.
Crescendo in depolarization and repolarization heterogeneity heralds development of ventricular tachycardia in hospitalized patients with decompensated heart failure.
Verrier RL, Klingenheben T, Malik M, El-Sherif N, Exner DV, Hohnloser SH, Ikeda T, Martínez JP, Narayan SM, Nieminen T, Rosenbaum DS
Microvolt T-wave alternans physiological basis, methods of measurement, and clinical utility--consensus guideline by International Society for Holter and Noninvasive Electrocardiology. J Am Coll Cardiol. 2011 Sep 20; 58(13):1309-24.
Microvolt T-wave alternans physiological basis, methods of measurement, and clinical utility--consensus guideline by International Society for Holter and Noninvasive Electrocardiology.
Assessing risk for rehospitalization and cardiac death in patients with heart failure: Can the dynamic duo of heart rate turbulence and T-wave alternans help? J Cardiovasc Electrophysiol. 2018 09; 29(9):1265-1267.
Assessing risk for rehospitalization and cardiac death in patients with heart failure: Can the dynamic duo of heart rate turbulence and T-wave alternans help?
Dynamic tracking of cardiac vulnerability by complex demodulation of the T wave. Science. 1991 Apr 19; 252(5004):437-40.
Dynamic tracking of cardiac vulnerability by complex demodulation of the T wave.
Pope CA, Verrier RL, Lovett EG, Larson AC, Raizenne ME, Kanner RE, Schwartz J, Villegas GM, Gold DR, Dockery DW
Heart rate variability associated with particulate air pollution. Am Heart J. 1999 Nov; 138(5 Pt 1):890-9.
Heart rate variability associated with particulate air pollution.
Gold DR, Litonjua A, Schwartz J, Lovett E, Larson A, Nearing B, Allen G, Verrier M, Cherry R, Verrier R
Ambient pollution and heart rate variability. Circulation. 2000 Mar 21; 101(11):1267-73.
Ambient pollution and heart rate variability.
Wellenius GA, Coull BA, Godleski JJ, Koutrakis P, Okabe K, Savage ST, Lawrence JE, Murthy GG, Verrier RL
Inhalation of concentrated ambient air particles exacerbates myocardial ischemia in conscious dogs. Environ Health Perspect. 2003 Apr; 111(4):402-8.
Inhalation of concentrated ambient air particles exacerbates myocardial ischemia in conscious dogs.
Stocco FG, Evaristo E, Silva AC, de Antonio VZ, Pfeiffer J, Rangachari N, Belardinelli L, Verrier RL
Comparative Pharmacokinetic and Electrocardiographic Effects of Intratracheal and Intravenous Administration of Flecainide in Anesthetized Pigs. J Cardiovasc Pharmacol. 2018 09; 72(3):129-135.
Comparative Pharmacokinetic and Electrocardiographic Effects of Intratracheal and Intravenous Administration of Flecainide in Anesthetized Pigs.
The power of the patch: A smart way to track risk for Torsades de pointes in congenital and drug-induced long QT syndromes? Int J Cardiol. 2018 09 01; 266:145-146.
The power of the patch: A smart way to track risk for Torsades de pointes in congenital and drug-induced long QT syndromes?
Verrier RL, Bortolotto AL, Silva BA, Marum AA, Stocco FG, Evaristo E, de Antonio VZ, Silva AC, Belardinelli L
Accelerated conversion of atrial fibrillation to normal sinus rhythm by pulmonary delivery of flecainide acetate in a porcine model. Heart Rhythm. 2018 12; 15(12):1882-1888.
Accelerated conversion of atrial fibrillation to normal sinus rhythm by pulmonary delivery of flecainide acetate in a porcine model.
The effects of psychological stress and vagal stimulation with morphine on vulnerability to ventricular fibrillation (VF) in the conscious dog. Am Heart J. 1978 Feb; 95(2):197-203.
The effects of psychological stress and vagal stimulation with morphine on vulnerability to ventricular fibrillation (VF) in the conscious dog.
Sleep, dreams, and sudden death: the case for sleep as an autonomic stress test for the heart. Cardiovasc Res. 1996 Feb; 31(2):181-211.
Sleep, dreams, and sudden death: the case for sleep as an autonomic stress test for the heart.
Takasugi N, Kubota T, Nishigaki K, Verrier RL, Kawasaki M, Takasugi M, Ushikoshi H, Hattori A, Ojio S, Aoyama T, Takemura G, Minatoguchi S
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
Should T-wave alternans magnitude be corrected with T-wave amplitude in the ultra-short-term prediction of life-threatening cardiac arrhythmias? Europace. 2011 Oct; 13(10):1512-3.
Should T-wave alternans magnitude be corrected with T-wave amplitude in the ultra-short-term prediction of life-threatening cardiac arrhythmias?
Kop WJ, Krantz DS, Nearing BD, Gottdiener JS, Quigley JF, O'Callahan M, DelNegro AA, Friehling TD, Karasik P, Suchday S, Levine J, Verrier RL
Effects of acute mental stress and exercise on T-wave alternans in patients with implantable cardioverter defibrillators and controls. Circulation. 2004 Apr 20; 109(15):1864-9.
Effects of acute mental stress and exercise on T-wave alternans in patients with implantable cardioverter defibrillators and controls.
Frayed nerves in myocardial infarction: the importance of rewiring. Circ Res. 2004 Jul 09; 95(1):5-6.
Frayed nerves in myocardial infarction: the importance of rewiring.
Leino J, Minkkinen M, Nieminen T, Lehtimäki T, Viik J, Lehtinen R, Nikus K, Kööbi T, Turjanmaa V, Verrier RL, Kähönen M
Combined assessment of heart rate recovery and T-wave alternans during routine exercise testing improves prediction of total and cardiovascular mortality: the Finnish Cardiovascular Study. Heart Rhythm. 2009 Dec; 6(12):1765-71.
Combined assessment of heart rate recovery and T-wave alternans during routine exercise testing improves prediction of total and cardiovascular mortality: the Finnish Cardiovascular Study.
Nieminen T, Verrier RL, Nikus K, Viik J, Lehtinen R, Lehtimäki T, Kaiser W, Kähönen M
Pattern of crescendo TWA may disclose the underlying cardiac pathology. J Electrocardiol. 2010 Sep-Oct; 43(5):449-51.
Pattern of crescendo TWA may disclose the underlying cardiac pathology.
Macroscopic T-wave alternans: the tip of the iceberg in drug-induced torsade de pointes? J Am Coll Cardiol. 2010 Jul 13; 56(3):241; author reply 241-2.
Macroscopic T-wave alternans: the tip of the iceberg in drug-induced torsade de pointes?
Continuous T-wave alternans monitoring to predict impending life-threatening cardiac arrhythmias during emergent coronary reperfusion therapy in patients with acute coronary syndrome. Europace. 2011 May; 13(5):708-15.
Continuous T-wave alternans monitoring to predict impending life-threatening cardiac arrhythmias during emergent coronary reperfusion therapy in patients with acute coronary syndrome.
Mechanisms involved in reperfusion arrhythmias. Eur Heart J. 1986 May; 7 Suppl A:13-22.
Mechanisms involved in reperfusion arrhythmias.
Influence of autonomic nervous system stimulation on the protective zone. Cardiovasc Res. 1981 Feb; 15(2):92-7.
Influence of autonomic nervous system stimulation on the protective zone.
Journal of applied physiology (Bethesda, Md. : 1985)
Personal computer system for tracking cardiac vulnerability by complex demodulation of the T wave. J Appl Physiol (1985). 1993 May; 74(5):2606-12.
Personal computer system for tracking cardiac vulnerability by complex demodulation of the T wave.
Vulnerability to ventricular fibrillation during acute coronary arterial occlusion and release. Am J Cardiol. 1975 Nov; 36(6):776-82.
Vulnerability to ventricular fibrillation during acute coronary arterial occlusion and release.
Hohnloser SH, Verrier RL, Lown B, Raeder EA
Effect of hypokalemia on susceptibility to ventricular fibrillation in the normal and ischemic canine heart. Am Heart J. 1986 Jul; 112(1):32-5.
Effect of hypokalemia on susceptibility to ventricular fibrillation in the normal and ischemic canine heart.
Behavioral stress and cardiac arrhythmias. Annu Rev Physiol. 1984; 46:155-76.
Behavioral stress and cardiac arrhythmias.
de Antonio VZ, Silva AC, Stocco FG, Silva BA, Marum AA, Bortolotto AL, Belardinelli L, Verrier RL
Pulmonary delivery of flecainide causes a rate-dependent predominant effect on atrial compared with ventricular depolarization duration revealed by intracardiac recordings in an intact porcine model. J Cardiovasc Electrophysiol. 2018 11; 29(11):1563-1569.
Pulmonary delivery of flecainide causes a rate-dependent predominant effect on atrial compared with ventricular depolarization duration revealed by intracardiac recordings in an intact porcine model.
Experimental studies of psychophysiological factors in sudden cardiac death. Acta Med Scand Suppl. 1982; 660:57-68.
Experimental studies of psychophysiological factors in sudden cardiac death.
Extra-adrenergic mechanisms responsible for the effects of glucose-insulin-potassium solution on vulnerability to ventricular fibrillation. Am J Cardiol. 1981 Feb; 47(2):251-7.
Extra-adrenergic mechanisms responsible for the effects of glucose-insulin-potassium solution on vulnerability to ventricular fibrillation.
Effects of prostacyclin (PGI2) on vulnerability to ventricular fibrillation in the normal and ischemic canine heart. Eur J Pharmacol. 1982 May 07; 80(1):83-91.
Effects of prostacyclin (PGI2) on vulnerability to ventricular fibrillation in the normal and ischemic canine heart.
Comparative effects of the opioids fentanyl and buprenorphine on ventricular vulnerability during acute coronary artery occlusion. Cardiovasc Res. 1989 Dec; 23(12):1001-6.
Comparative effects of the opioids fentanyl and buprenorphine on ventricular vulnerability during acute coronary artery occlusion.
Digitalis drugs and vulnerability to ventricular fibrillation. Eur J Pharmacol. 1979 Jul 15; 57(1):69-78.
Digitalis drugs and vulnerability to ventricular fibrillation.
Is heart disease in chronic epilepsy a consequence of seizures or a fellow traveler? Epilepsy Behav. 2018 09; 86:211-213.
Is heart disease in chronic epilepsy a consequence of seizures or a fellow traveler?
Activator calcium for non-neurogenic tone of vascular smooth muscle. Angiologica. 1971; 8(3-5):161-71.
Activator calcium for non-neurogenic tone of vascular smooth muscle.
Research publications - Association for Research in Nervous and Mental Disease
Autonomic nervous system and malignant cardiac arrhythmias. Res Publ Assoc Res Nerv Ment Dis. 1981; 59:273-91.
Autonomic nervous system and malignant cardiac arrhythmias.
Annals of the New York Academy of Sciences
Myocardial perfusion and neurally induced cardiac arrhythmias. Ann N Y Acad Sci. 1984; 427:171-86.
Myocardial perfusion and neurally induced cardiac arrhythmias.
Acute blood pressure elevation and ventricular fibrillation threshold during coronary occlusion and reperfusion in the dog. Am J Cardiol. 1977 Apr; 39(4):523-8.
Acute blood pressure elevation and ventricular fibrillation threshold during coronary occlusion and reperfusion in the dog.
The stress of sleep in patients prone to atrial tachyarrhythmias. J Cardiovasc Electrophysiol. 2012 Jun; 23(6):612-3.
The stress of sleep in patients prone to atrial tachyarrhythmias.
Nearing BD, Mittleman MA, Josephson ME, Verrier RL, Wellenius GA, Burger AJ
Response to letter regarding article, "crescendo in depolarization and repolarization heterogeneity heralds development of ventricular tachycardia in hospitalized patients with decompensated heart failure". Circ Arrhythm Electrophysiol. 2012 Jun 1; 5(3):e79.
Response to letter regarding article, "crescendo in depolarization and repolarization heterogeneity heralds development of ventricular tachycardia in hospitalized patients with decompensated heart failure".
Marum AA, Silva BA, Bortolotto AL, Silva AC, de Antonio VZ, Belardinelli L, Verrier RL
Optimizing flecainide plasma concentration profile for atrial fibrillation conversion while minimizing adverse ventricular effects by rapid, low-dose intratracheal or intravenous administration. Int J Cardiol. 2019 Jan 01; 274:170-174.
Optimizing flecainide plasma concentration profile for atrial fibrillation conversion while minimizing adverse ventricular effects by rapid, low-dose intratracheal or intravenous administration.
To the editor--Biological pacemakers exhibit positive chronotropic response to emotional arousal. Heart Rhythm. 2012 Dec; 9(12):e30.
To the editor--Biological pacemakers exhibit positive chronotropic response to emotional arousal.
Verrier RL, Pagotto VP, Kanas AF, Sobrado MF, Nearing BD, Zeng D, Belardinelli L
Low doses of ranolazine and dronedarone in combination exert potent protection against atrial fibrillation and vulnerability to ventricular arrhythmias during acute myocardial ischemia. Heart Rhythm. 2013 Jan; 10(1):121-7.
Low doses of ranolazine and dronedarone in combination exert potent protection against atrial fibrillation and vulnerability to ventricular arrhythmias during acute myocardial ischemia.
Zipes DP, Levy MN, Cobb LA, Julius S, Kaufman PG, Miller NE, Verrier RL
Sudden cardiac death. Neural-cardiac interactions. Circulation. 1987 Jul; 76(1 Pt 2):I202-7.
Sudden cardiac death. Neural-cardiac interactions.
Circulation journal : official journal of the Japanese Circulation Society
Independent and complementary utility of ambulatory electrocardiogram-based T-wave alternans and heart rate turbulence for predicting major cardiac events in patients after myocardial infarction. Circ J. 2013; 77(4):1084-5.
Independent and complementary utility of ambulatory electrocardiogram-based T-wave alternans and heart rate turbulence for predicting major cardiac events in patients after myocardial infarction.
Sleep and cardiac arrhythmias. Ann N Y Acad Sci. 1988; 533:238-51.
Prevention of ventricular fibrillation by use of low-intensity electrical stimuli. Ann N Y Acad Sci. 1982; 382:355-70.
Prevention of ventricular fibrillation by use of low-intensity electrical stimuli.
Effects of sulfinpyrazone on ventricular vulnerability in the normal and the ischemic heart. Am J Cardiol. 1982 Aug; 50(2):271-5.
Effects of sulfinpyrazone on ventricular vulnerability in the normal and the ischemic heart.
Dickerson LW, Huang AH, Nearing BD, Verrier RL
Primary coronary vasodilation associated with pauses in heart rhythm during sleep. Am J Physiol. 1993 Jan; 264(1 Pt 2):R186-96.
Primary coronary vasodilation associated with pauses in heart rhythm during sleep.
Verrier RL, Kwaku KF, Nearing BD, Josephson ME
T-wave alternans: does size matter. J Cardiovasc Electrophysiol. 2005 Jun; 16(6):625-8.
Dockery DW, Luttmann-Gibson H, Rich DQ, Link MS, Schwartz JD, Gold DR, Koutrakis P, Verrier RL, Mittleman MA
Research report (Health Effects Institute)
Particulate air pollution and nonfatal cardiac events. Part II. Association of air pollution with confirmed arrhythmias recorded by implanted defibrillators. Res Rep Health Eff Inst. 2005 Jun; (124):83-126; discussion 127-48.
Particulate air pollution and nonfatal cardiac events. Part II. Association of air pollution with confirmed arrhythmias recorded by implanted defibrillators.
Triggering of sudden death--lessons from an earthquake. N Engl J Med. 1996 Feb 15; 334(7):460-1.
Triggering of sudden death--lessons from an earthquake.
Relationship between sympathetic neural activity, coronary dynamics, and vulnerability to ventricular fibrillation during myocardial ischemia and reperfusion. Am Heart J. 1983 Jun; 105(6):958-65.
Relationship between sympathetic neural activity, coronary dynamics, and vulnerability to ventricular fibrillation during myocardial ischemia and reperfusion.
Hypoperfusion of the myocardium relative to myocardial metabolism during delayed coronary constriction. Cardiovasc Res. 1993 Mar; 27(3):435-41.
Hypoperfusion of the myocardium relative to myocardial metabolism during delayed coronary constriction.
Zanobetti A, Stone PH, Speizer FE, Schwartz JD, Coull BA, Suh HH, Nearing BD, Mittleman MA, Verrier RL, Gold DR
T-wave alternans, air pollution and traffic in high-risk subjects. Am J Cardiol. 2009 Sep 01; 104(5):665-70.
T-wave alternans, air pollution and traffic in high-risk subjects.
Antiarrhythmic drug effects on microvolt T-wave alternans: measurement nuisance or indicator of therapeutic action? J Cardiovasc Electrophysiol. 2010 Nov; 21(11):E79.
Antiarrhythmic drug effects on microvolt T-wave alternans: measurement nuisance or indicator of therapeutic action?
Microvolt T-wave alternans testing has a role in arrhythmia risk stratification. J Am Coll Cardiol. 2012 Apr 24; 59(17):1572-3.
Microvolt T-wave alternans testing has a role in arrhythmia risk stratification.
Intrinsic sympathomimetic activity and the effects of beta-adrenergic blocking drugs on vulnerability to ventricular fibrillation. J Am Coll Cardiol. 1983 Jun; 1(6):1442-6.
Intrinsic sympathomimetic activity and the effects of beta-adrenergic blocking drugs on vulnerability to ventricular fibrillation.
Influence of intracoronary platelet aggregation on ventricular electrical properties during partial coronary artery stenosis. Am J Cardiol. 1983 Feb; 51(3):596-602.
Influence of intracoronary platelet aggregation on ventricular electrical properties during partial coronary artery stenosis.
Kowey PR, Khuri S, Josa M, Verrier RL, Sharma S, Kiely JP, Folland ED, Parisi AF
Vulnerability to ventricular fibrillation in patients with clinically manifest ventricular tachycardia. Am Heart J. 1984 Oct; 108(4 Pt 1):884-9.
Vulnerability to ventricular fibrillation in patients with clinically manifest ventricular tachycardia.
Sympathetic activity as the cause of the morning increase in cardiac events. A likely culprit, but the evidence remains circumstantial. Circulation. 1995 May 15; 91(10):2508-9.
Sympathetic activity as the cause of the morning increase in cardiac events. A likely culprit, but the evidence remains circumstantial.
Influence of vagal tone on stellectomy-induced changes in ventricular electrical stability. Am J Physiol. 1978 May; 234(5):H503-7.
Influence of vagal tone on stellectomy-induced changes in ventricular electrical stability.
The repetitive extrasystole as an index of vulnerability to ventricular fibrillation during myocardial ischemia in the canine heart. Am Heart J. 1983 Dec; 106(6):1321-5.
The repetitive extrasystole as an index of vulnerability to ventricular fibrillation during myocardial ischemia in the canine heart.
Differing mechanisms for ventricular vulnerability during coronary artery occlusion and release. Am Heart J. 1976 Aug; 92(2):223-30.
Differing mechanisms for ventricular vulnerability during coronary artery occlusion and release.
Delayed myocardial ischemia following the cessation of sympathetic stimulation. Am Heart J. 1988 Jan; 115(1 Pt 1):45-53.
Delayed myocardial ischemia following the cessation of sympathetic stimulation.
Weiner DE, Verrier RL, Miller DT, Lefer AM
Effect of adrenalectomy on hemodynamics and regional blood flow in the cat. Am J Physiol. 1967 Aug; 213(2):473-6.
Effect of adrenalectomy on hemodynamics and regional blood flow in the cat.
Psychologic stress and threshold for repetitive ventricular response. Science. 1973 Nov 23; 182(4114):834-6.
Psychologic stress and threshold for repetitive ventricular response.
Blood volume and myocardial function in adrenal insufficiency. Am J Physiol. 1969 Dec; 217(6):1559-64.
Blood volume and myocardial function in adrenal insufficiency.
Protective zone and the determination of vulnerability to ventricular fibrillation. Am J Physiol. 1978 May; 234(5):H592-6.
Protective zone and the determination of vulnerability to ventricular fibrillation.
Anttila I, Nikus K, Kähönen M, Jula A, Reunanen A, Salomaa V, Nieminen MS, Lehtimäki T, Virtanen V, Verrier RL, Varis J, Sclarovsky S, Nieminen T
Prognostic implications of quantitative ST-segment characteristics and T-wave amplitude for cardiovascular mortality in a general population from the Health 2000 Survey. Ann Med. 2010 Oct; 42(7):502-11.
Prognostic implications of quantitative ST-segment characteristics and T-wave amplitude for cardiovascular mortality in a general population from the Health 2000 Survey.
Non-neurogenic tone in isolated perfused resistance vessels. Circ Res. 1971 Jan; 28:Suppl 1:59-64.
Non-neurogenic tone in isolated perfused resistance vessels.
Effect of posterior hypothalamic stimulation on ventricular fibrillation threshold. Am J Physiol. 1975 Mar; 228(3):923-7.
Effect of posterior hypothalamic stimulation on ventricular fibrillation threshold.
Verrier RL, Nearing BD, La Rovere MT, Pinna GD, Mittleman MA, Bigger JT, Schwartz PJ
Ambulatory electrocardiogram-based tracking of T wave alternans in postmyocardial infarction patients to assess risk of cardiac arrest or arrhythmic death. J Cardiovasc Electrophysiol. 2003 Jul; 14(7):705-11.
Ambulatory electrocardiogram-based tracking of T wave alternans in postmyocardial infarction patients to assess risk of cardiac arrest or arrhythmic death.
Schwartz J, Litonjua A, Suh H, Verrier M, Zanobetti A, Syring M, Nearing B, Verrier R, Stone P, MacCallum G, Speizer FE, Gold DR
Traffic related pollution and heart rate variability in a panel of elderly subjects. Thorax. 2005 Jun; 60(6):455-61.
Traffic related pollution and heart rate variability in a panel of elderly subjects.
Neural influences and sudden cardiac death. Adv Cardiol. 1978; 25:155-68.
Neural influences and sudden cardiac death.
Chen JC, Stone PH, Verrier RL, Nearing BD, MacCallum G, Kim JY, Herrick RF, You J, Zhou H, Christiani DC
Journal of occupational and environmental medicine
Personal coronary risk profiles modify autonomic nervous system responses to air pollution. J Occup Environ Med. 2006 Nov; 48(11):1133-42.
Personal coronary risk profiles modify autonomic nervous system responses to air pollution.
Abolition of clonidine's effects on ventricular refractoriness by naloxone in the conscious dog. Life Sci. 1989; 45(5):413-20.
Abolition of clonidine's effects on ventricular refractoriness by naloxone in the conscious dog.
Differential effects of sleep stage on coronary hemodynamic function during stenosis. Physiol Behav. 1989 May; 45(5):1017-20.
Differential effects of sleep stage on coronary hemodynamic function during stenosis.
Huikuri HV, Verrier RL, Malik M, Lombardi F, Schmidt G, Zabel M
To the Editor- Our doubts about the usefulness of the Tpeak-Tend interval. Heart Rhythm. 2019 06; 16(6):e49.
To the Editor- Our doubts about the usefulness of the Tpeak-Tend interval.
Malik M, Huikuri HV, Lombardi F, Schmidt G, Verrier RL, Zabel M
Is the Tpeak-Tend interval as a measure of repolarization heterogeneity dead or just seriously wounded? Heart Rhythm. 2019 06; 16(6):952-953.
Is the Tpeak-Tend interval as a measure of repolarization heterogeneity dead or just seriously wounded?
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Protective effect of prenylamine against vulnerability to ventricular fibrillation in the normal and ischemic canine myocardium. Proc Soc Exp Biol Med. 1979 May; 161(1):56-9.
Protective effect of prenylamine against vulnerability to ventricular fibrillation in the normal and ischemic canine myocardium.
Repetitive extrasystole as an index of vulnerability to ventricular fibrillation. Am J Physiol. 1976 Jun; 230(6):1469-73.
Repetitive extrasystole as an index of vulnerability to ventricular fibrillation.
Correlation between circulating catecholamine levels and ventricular vulnerability during psychological stress in conscious dogs. Proc Soc Exp Biol Med. 1979 Jul; 161(3):266-9.
Correlation between circulating catecholamine levels and ventricular vulnerability during psychological stress in conscious dogs.
Altered mechano-electrical coupling: An underappreciated factor in sympathetically mediated torsades de pointes in the long QT1 syndrome. Int J Cardiol. 2019 07 01; 286:81-82.
Altered mechano-electrical coupling: An underappreciated factor in sympathetically mediated torsades de pointes in the long QT1 syndrome.
Takasugi N, Takasugi M, Goto H, Kuwahara T, Kawasaki M, Verrier RL
Effect of beta-blockade on quantitative microvolt T-wave alternans in 24-hour continuous 12-lead ECG recordings in patients with long QT syndrome. Ann Noninvasive Electrocardiol. 2019 07; 24(4):e12640.
Effect of beta-blockade on quantitative microvolt T-wave alternans in 24-hour continuous 12-lead ECG recordings in patients with long QT syndrome.
Interdisciplinary Medicine and Biotechnology
George Richards Minot Professor of Medicine
Takasugi N, Matsuno H, Takasugi M, Shinoda K, Watanabe T, Ito H, Okura H, Verrier RL
Importance of over-reading ambulatory ECG-based microvolt T-wave alternans to eliminate three main sources of measurement error. Ann Noninvasive Electrocardiol. 2019 09; 24(5):e12670.
Importance of over-reading ambulatory ECG-based microvolt T-wave alternans to eliminate three main sources of measurement error.
Silva AC, de Antonio VZ, Sroubek J, Gervino E, Ho K, Medeiros SA, Silva FT, Pedreira GC, Stocco FG, Nearing BD, Verrier RL
Exercise and pharmacologic stress-induced interlead T-wave heterogeneity analysis to detect clinically significant coronary artery stenosis. Int J Cardiol. 2020 01 01; 298:32-38.
Exercise and pharmacologic stress-induced interlead T-wave heterogeneity analysis to detect clinically significant coronary artery stenosis.
Pang TD, Nearing BD, Krishnamurthy KB, Olin B, Schachter SC, Verrier RL
Cardiac electrical instability in newly diagnosed/chronic epilepsy tracked by Holter and ECG patch. Neurology. 2019 09 03; 93(10):450-458.
Cardiac electrical instability in newly diagnosed/chronic epilepsy tracked by Holter and ECG patch.
Response to the Letter to the Editor. Ann Noninvasive Electrocardiol. 2019 11; 24(6):e12720.
Tessarolo Silva F, Pedreira GC, Medeiros SA, Bortolotto AL, Araujo Silva B, Hurrey M, Madhavapeddi P, Schuler C, Belardinelli L, Verrier RL
Multimodal mechanisms and enhanced efficiency of atrial fibrillation cardioversion by pulmonary delivery of a novel flecainide formulation. J Cardiovasc Electrophysiol. 2020 01; 31(1):205-213.
Multimodal mechanisms and enhanced efficiency of atrial fibrillation cardioversion by pulmonary delivery of a novel flecainide formulation.
Marum AA, Araujo Silva B, Bortolotto AL, Pedreira GC, Tessarolo Silva F, Medeiros SA, Nearing BD, Belardinelli L, Verrier RL
Pulmonary Delivery of Metoprolol Reduces Ventricular Rate During Atrial Fibrillation and Accelerates Conversion to Sinus Rhythm. J Cardiovasc Pharmacol. 2020 02; 75(2):135-140.
Pulmonary Delivery of Metoprolol Reduces Ventricular Rate During Atrial Fibrillation and Accelerates Conversion to Sinus Rhythm.
Pulmonary Delivery of Antiarrhythmic Drugs for Rapid Conversion of New-Onset Atrial Fibrillation. J Cardiovasc Pharmacol. 2020 04; 75(4):276-283.
Pulmonary Delivery of Antiarrhythmic Drugs for Rapid Conversion of New-Onset Atrial Fibrillation.
Verrier RL, Pang TD, Nearing BD, Schachter SC
The Epileptic Heart: Concept and clinical evidence. Epilepsy Behav. 2020 04; 105:106946.
The Epileptic Heart: Concept and clinical evidence.
Response to Letter to the Editor by Drs. Fialho and colleagues. Epilepsy Behav. 2020 07; 108:107040.
Response to Letter to the Editor by Drs. Fialho and colleagues.
Bortolotto AL, Verrier RL, Nearing BD, Marum AA, Araujo Silva B, Pedreira GC, Tessarolo Silva F, Medeiros SA, Sroubek J, Zimetbaum PJ, Chang JD
Preimplantation interlead ECG heterogeneity is superior to QRS complex duration in predicting mechanical super-response in patients with non-left bundle branch block receiving cardiac resynchronization therapy. Heart Rhythm. 2020 11; 17(11):1887-1896.
Preimplantation interlead ECG heterogeneity is superior to QRS complex duration in predicting mechanical super-response in patients with non-left bundle branch block receiving cardiac resynchronization therapy.
Araujo Silva B, Hauser TH, Nearing BD, Bortolotto AL, Marum AA, Tessarolo Silva F, Medeiros SA, Pedreira GC, Gervino EV, Verrier RL
European heart journal. Cardiovascular Imaging
Regadenoson-induced T-wave heterogeneity complements coronary stenosis detection by myocardial perfusion imaging in men and women. Eur Heart J Cardiovasc Imaging. 2021 10 19; 22(11):1341-1349.
Regadenoson-induced T-wave heterogeneity complements coronary stenosis detection by myocardial perfusion imaging in men and women.
Nearing BD, Anand IS, Libbus I, Dicarlo LA, Kenknight BH, Verrier RL
Vagus Nerve Stimulation Provides Multiyear Improvements in Autonomic Function and Cardiac Electrical Stability in the ANTHEM-HF Study. J Card Fail. 2021 Feb; 27(2):208-216.
Vagus Nerve Stimulation Provides Multiyear Improvements in Autonomic Function and Cardiac Electrical Stability in the ANTHEM-HF Study.
Indian pacing and electrophysiology journal
Modified Moving Average T-wave alternans cutpoints. Indian Pacing Electrophysiol J. 2021 Mar-Apr; 21(2):139.
Modified Moving Average T-wave alternans cutpoints.
Monteiro FR, Rabelo Evangelista AB, Nearing BD, Medeiros SA, Tessarolo Silva F, Pedreira GC, Ullman E, Gervino EV, Verrier RL
T-wave heterogeneity in standard resting 12-lead ECGs is associated with 90-day cardiac mortality in women following emergency department admission: A nested case-control study. Ann Noninvasive Electrocardiol. 2021 05; 26(3):e12826.
T-wave heterogeneity in standard resting 12-lead ECGs is associated with 90-day cardiac mortality in women following emergency department admission: A nested case-control study.
Serber ER, Christon LM, Fava JL, Verrier RL, Nearing BD, Buxton AE, Gold MR, Rodrigue JR, Frisch MB
Positive Psychotherapy Improves Cardiac Electrical Stability and Mood in ICD Patients: PAM-ICD Trial Results. Psychosom Med. 2021 04 01; 83(3):300-301.
Positive Psychotherapy Improves Cardiac Electrical Stability and Mood in ICD Patients: PAM-ICD Trial Results.
Nearing BD, Libbus I, Carlson GM, Amurthur B, KenKnight BH, Verrier RL
Clinical autonomic research : official journal of the Clinical Autonomic Research Society
Chronic vagus nerve stimulation is associated with multi-year improvement in intrinsic heart rate recovery and left ventricular ejection fraction in ANTHEM-HF. Clin Auton Res. 2021 06; 31(3):453-462.
Chronic vagus nerve stimulation is associated with multi-year improvement in intrinsic heart rate recovery and left ventricular ejection fraction in ANTHEM-HF.
Rabêlo Evangelista AB, Monteiro FR, Nearing BD, Belardinelli L, Verrier RL
Flecainide-induced QRS complex widening correlates with negative inotropy. Heart Rhythm. 2021 08; 18(8):1416-1422.
Flecainide-induced QRS complex widening correlates with negative inotropy.
Editorial commentary: "The allure of the pericardial space: How to get there and what to do". Trends Cardiovasc Med. 2022 05; 32(4):219-220.
Editorial commentary: "The allure of the pericardial space: How to get there and what to do".
Epileptic heart: A clinical syndromic approach. Epilepsia. 2021 08; 62(8):1780-1789.
Epileptic heart: A clinical syndromic approach.
Spectrum of clinical applications of interlead ECG heterogeneity assessment: From myocardial ischemia detection to sudden cardiac death risk stratification. Ann Noninvasive Electrocardiol. 2021 11; 26(6):e12894.
Spectrum of clinical applications of interlead ECG heterogeneity assessment: From myocardial ischemia detection to sudden cardiac death risk stratification.
Burke GM, Araujo Silva B, Marum AA, Bortolotto AL, Nearing BD, Chen MJ, Fostello S, Popma JJ, Verrier RL, Chang JD
Speckle tracking strain and ECG heterogeneity correlate in transcatheter aortic valve replacement-induced left bundle branch blocks and right ventricular paced rhythms. Open Heart. 2021 10; 8(2).
Speckle tracking strain and ECG heterogeneity correlate in transcatheter aortic valve replacement-induced left bundle branch blocks and right ventricular paced rhythms.
Conduction system versus biventricular pacing: Getting double for your trouble. J Cardiovasc Electrophysiol. 2022 02; 33(2):296-298.
Conduction system versus biventricular pacing: Getting double for your trouble.
Prolonged QT interval predicts all-cause mortality in epilepsy patients: Diagnostic and therapeutic implications. Heart Rhythm. 2022 04; 19(4):585-587.
Prolonged QT interval predicts all-cause mortality in epilepsy patients: Diagnostic and therapeutic implications.
Atrial ischemia: An underappreciated piece of the atrial fibrillation mosaic. Heart Rhythm. 2022 08; 19(8):1245-1246.
Atrial ischemia: An underappreciated piece of the atrial fibrillation mosaic.
Pang TD, Nearing BD, Verrier RL, Schachter SC
T-wave heterogeneity crescendo in the surface EKG is superior to heart rate acceleration for seizure prediction. Epilepsy Behav. 2022 05; 130:108670.
T-wave heterogeneity crescendo in the surface EKG is superior to heart rate acceleration for seizure prediction.
Mehra R, Tjurmina OA, Ajijola OA, Arora R, Bolser DC, Chapleau MW, Chen PS, Clancy CE, Delisle BP, Gold MR, Goldberger JJ, Goldstein DS, Habecker BA, Handoko ML, Harvey R, Hummel JP, Hund T, Meyer C, Redline S, Ripplinger CM, Simon MA, Somers VK, Stavrakis S, Taylor-Clark T, Undem BJ, Verrier RL, Zucker IH, Sopko G, Shivkumar K
Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop. JACC Basic Transl Sci. 2022 Mar; 7(3):265-293.
Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop.
Verrier RL, Libbus I, Nearing BD, KenKnight BH
Multifactorial Benefits of Chronic Vagus Nerve Stimulation on Autonomic Function and Cardiac Electrical Stability in Heart Failure Patients With Reduced Ejection Fraction. Front Physiol. 2022; 13:855756.
Multifactorial Benefits of Chronic Vagus Nerve Stimulation on Autonomic Function and Cardiac Electrical Stability in Heart Failure Patients With Reduced Ejection Fraction.
Response to letter to the editor by Dr. Guilherme Loureiro Fialho and Dr. Katia Lin: "T-wave heterogeneity in epilepsy: Could we kill two (or three) birds with one stone?" Epilepsy Behav. 2022 09; 134:108806.
Response to letter to the editor by Dr. Guilherme Loureiro Fialho and Dr. Katia Lin: "T-wave heterogeneity in epilepsy: Could we kill two (or three) birds with one stone?"
Pang TD, Nearing BD, Schachter SC, Verrier RL
Epileptic seizures and Epilepsy Monitoring Unit admission disclose latent cardiac electrical instability. Epilepsy Behav. 2022 10; 135:108881.
Epileptic seizures and Epilepsy Monitoring Unit admission disclose latent cardiac electrical instability.
The Epileptic Heart and the Case for Routine Use of the Electrocardiogram in Patients with Chronic Epilepsy. Neurol Clin. 2022 11; 40(4):699-716.
The Epileptic Heart and the Case for Routine Use of the Electrocardiogram in Patients with Chronic Epilepsy.
Editorial: Autonomic regulation of cardiovascular function and implications for future therapeutic approaches. Front Physiol. 2022; 13:1039876.
Editorial: Autonomic regulation of cardiovascular function and implications for future therapeutic approaches.
Continuous multi-day tracking of post-myocardial infarction recovery of cardiac electrical stability and autonomic tone using electrocardiogram patch monitors. Ann Noninvasive Electrocardiol. 2023 01; 28(1):e13035.
Continuous multi-day tracking of post-myocardial infarction recovery of cardiac electrical stability and autonomic tone using electrocardiogram patch monitors.
Fialho GL, Verrier RL, D'Avila A, Melo HM, Wolf P, Walz R, Lin K
Dual assessment of abnormal cardiac electrical dispersion and diastolic dysfunction for early detection of the epileptic heart condition. J Electrocardiol. 2023 May-Jun; 78:69-75.
Dual assessment of abnormal cardiac electrical dispersion and diastolic dysfunction for early detection of the epileptic heart condition.
Kumar HU, Nearing BD, Mittal S, Premchand RK, Libbus I, DiCarlo LA, Amurthur B, KenKnight BH, Anand IS, Verrier RL
Autonomic regulation therapy in chronic heart failure with preserved/mildly reduced ejection fraction: ANTHEM-HFpEF study results. Int J Cardiol. 2023 06 15; 381:37-44.
Autonomic regulation therapy in chronic heart failure with preserved/mildly reduced ejection fraction: ANTHEM-HFpEF study results.
Fialho GL, Pang TD, Kong WY, Tran AP, Yu CG, Rodriguez ID, Nearing BD, Waks JW, Maher TR, Clarke JR, Shepherd A, D'Avila A, Schachter SC, Verrier RL
Individuals with chronic epilepsy have elevated P-wave heterogeneity comparable to patients with atrial fibrillation. Epilepsia. 2023 09; 64(9):2361-2372.
Individuals with chronic epilepsy have elevated P-wave heterogeneity comparable to patients with atrial fibrillation.
Verrier RL, Maher TR, Kreidieh B, D'Avila ALB
Is inhibition of If in the atrioventricular node to control ventricular rate during atrial fibrillation ready for prime time? Heart Rhythm. 2023 06; 20(6):831-832.
Is inhibition of If in the atrioventricular node to control ventricular rate during atrial fibrillation ready for prime time?
Fialho GL, Nearing BD, Waks JW, Maher TR, Clarke JR, Shepherd A, D'Avila A, Verrier RL
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing
Reduction in atrial and ventricular electrical heterogeneity following pulmonary vein isolation in patients with atrial fibrillation. J Interv Card Electrophysiol. 2025 Mar; 68(2):335-346.
Reduction in atrial and ventricular electrical heterogeneity following pulmonary vein isolation in patients with atrial fibrillation.
Long-term risk for atrial and ventricular arrhythmias: a cardinal manifestation of 'the epileptic heart'. Eur Heart J. 2023 09 14; 44(35):3383-3385.
Long-term risk for atrial and ventricular arrhythmias: a cardinal manifestation of 'the epileptic heart'.
Editorial commentary: Clinical translation of vagus nerve stimulation in cardiovascular diseases: How bright is the light at the end of the tunnel? Trends Cardiovasc Med. 2024 07; 34(5):338-339.
Editorial commentary: Clinical translation of vagus nerve stimulation in cardiovascular diseases: How bright is the light at the end of the tunnel?
Antunes MO, Arteaga-Fernandez E, Samesima N, Pereira Filho HG, Matsumoto AY, Verrier RL, Pastore CA, Mady C
Prognostic Evaluation of Microvolt T-Wave Alternans in Hypertrophic Cardiomyopathy: 9-year Clinical Follow-up. Arq Bras Cardiol. 2023; 120(8):e20220833.
Prognostic Evaluation of Microvolt T-Wave Alternans in Hypertrophic Cardiomyopathy: 9-year Clinical Follow-up.
Novel application of convolutional neural networks for artificial intelligence-enabled modified moving average analysis of P-, R-, and T-wave alternans for detection of risk for atrial and ventricular arrhythmias. J Electrocardiol. 2024 Mar-Apr; 83:12-20.
Novel application of convolutional neural networks for artificial intelligence-enabled modified moving average analysis of P-, R-, and T-wave alternans for detection of risk for atrial and ventricular arrhythmias.
Nearing BD, Fialho GL, Waks JW, Maher TR, Clarke JR, Shepherd AJ, D'Avila A, Verrier RL
P-wave alternans rebound following pulmonary vein isolation predicts atrial arrhythmia recurrence. J Cardiovasc Electrophysiol. 2024 Jul; 35(7):1360-1367.
P-wave alternans rebound following pulmonary vein isolation predicts atrial arrhythmia recurrence.
Lauretti C, Antonio GL, Fernandes AE, Stocco FG, Girardi ACC, Verrier RL, Caramelli B
Empagliflozin's role in reducing ventricular repolarization heterogeneity: insights into cardiovascular mortality decline from the EMPATHY-HEART trial. Cardiovasc Diabetol. 2024 06 26; 23(1):221.
Empagliflozin's role in reducing ventricular repolarization heterogeneity: insights into cardiovascular mortality decline from the EMPATHY-HEART trial.
The Epileptic Heart Syndrome: Epidemiology, pathophysiology and clinical detection. Epilepsy Behav Rep. 2024; 27:100696.
The Epileptic Heart Syndrome: Epidemiology, pathophysiology and clinical detection.
Verrier RL, Nearing BD, Ghanem RN, Olson RE, Garberich RF, Katsiyiannis WT, Gornick CC, Tang CY, Henry TD
Elevated T-wave alternans predicts nonsustained ventricular tachycardia in association with percutaneous coronary intervention in ST-segment elevation myocardial infarction (STEMI) patients. J Cardiovasc Electrophysiol. 2013 Jun; 24(6):658-63.
Elevated T-wave alternans predicts nonsustained ventricular tachycardia in association with percutaneous coronary intervention in ST-segment elevation myocardial infarction (STEMI) patients.
Sobrado LF, Varone BB, Machado AD, Nearing BD, Zeng D, Belardinelli L, Verrier RL
Dronedarone's inhibition of If current is the primary mechanism responsible for its bradycardic effect. J Cardiovasc Electrophysiol. 2013 Aug; 24(8):914-8.
Dronedarone's inhibition of If current is the primary mechanism responsible for its bradycardic effect.
The brain-heart connection: Value of concurrent ECG and EEG recordings in epilepsy management. Epilepsy Behav Rep. 2024; 28:100726.
The brain-heart connection: Value of concurrent ECG and EEG recordings in epilepsy management.
Response to Letter by J Finsterer MD. Epilepsy Behav Rep. 2024; 28:100719.
The role of the autonomic nervous system in cardiac arrhythmias. Handb Clin Neurol. 2013; 117:135-45.
The role of the autonomic nervous system in cardiac arrhythmias.
Management recommendations to reduce cardiac risk in chronic epilepsy. Epilepsy Behav Rep. 2025 Mar; 29:100738.
Management recommendations to reduce cardiac risk in chronic epilepsy.
Ranolazine's sweet side--improvement of glycaemic control by the novel mechanism of skeletal muscle microvascular recruitment. J Physiol. 2013 Oct 15; 591(20):4961.
Ranolazine's sweet side--improvement of glycaemic control by the novel mechanism of skeletal muscle microvascular recruitment.
Clinical applications of T-wave alternans assessed during exercise stress testing and ambulatory ECG monitoring. J Electrocardiol. 2013 Nov-Dec; 46(6):585-90.
Clinical applications of T-wave alternans assessed during exercise stress testing and ambulatory ECG monitoring.
Verrier RL, Sobrado MF, Pagotto VP, Kanas AF, Machado AD, Varone BB, Sobrado LF, Nearing BD, Zeng D, Belardinelli L
Inhibition of I(f) in the atrioventricular node as a mechanism for dronedarone's reduction in ventricular rate during atrial fibrillation. Heart Rhythm. 2013 Nov; 10(11):1692-7.
Inhibition of I(f) in the atrioventricular node as a mechanism for dronedarone's reduction in ventricular rate during atrial fibrillation.
Electrophysiology of T-wave alternans: mechanisms and pharmacologic influences. J Electrocardiol. 2013 Nov-Dec; 46(6):580-4.
Electrophysiology of T-wave alternans: mechanisms and pharmacologic influences.
Ambulatory ECG-based T-wave alternans monitoring for risk assessment and guiding medical therapy: mechanisms and clinical applications. Prog Cardiovasc Dis. 2013 Sep-Oct; 56(2):172-85.
Ambulatory ECG-based T-wave alternans monitoring for risk assessment and guiding medical therapy: mechanisms and clinical applications.
Strauss DG, Mewton N, Verrier RL, Nearing BD, Marchlinski FE, Killian T, Moxley J, Tereshchenko LG, Wu KC, Winslow R, Cox C, Spooner PM, Lima JA
Screening entire health system ECG databases to identify patients at increased risk of death. Circ Arrhythm Electrophysiol. 2013 Dec; 6(6):1156-62.
Screening entire health system ECG databases to identify patients at increased risk of death.
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology
Is there a role of MMA T wave alternans test for risk assessment in Brugada syndrome? Anadolu Kardiyol Derg. 2014 Feb; 14(1):96.
Is there a role of MMA T wave alternans test for risk assessment in Brugada syndrome?
Goto H, Takasugi N, Kuwahara T, Verrier RL
QRST-wave alternans in a child with type 3 long-QT syndrome: an ominous ECG pattern appearing during transition from T-wave alternans to polymorphic VT. J Cardiovasc Electrophysiol. 2014 Jun; 25(6):657-8.
QRST-wave alternans in a child with type 3 long-QT syndrome: an ominous ECG pattern appearing during transition from T-wave alternans to polymorphic VT.
Nieminen T, Scirica BM, Pegler JR, Tavares C, Pagotto VP, Kanas AF, Sobrado MF, Nearing BD, Umez-Eronini AA, Morrow DA, Belardinelli L, Verrier RL
Relation of T-wave alternans to mortality and nonsustained ventricular tachycardia in patients with non-ST-segment elevation acute coronary syndrome from the MERLIN-TIMI 36 trial of ranolazine versus placebo. Am J Cardiol. 2014 Jul 01; 114(1):17-23.
Relation of T-wave alternans to mortality and nonsustained ventricular tachycardia in patients with non-ST-segment elevation acute coronary syndrome from the MERLIN-TIMI 36 trial of ranolazine versus placebo.
Goto H, Takasugi N, Verrier RL, Kuwahara T
T-wave alternans, QRST-wave alternans and atrioventricular block: three consecutive rate-dependent phenomena in a child with congenital long-QT syndrome. J Cardiovasc Electrophysiol. 2013 Oct; 24(10):1183-4.
T-wave alternans, QRST-wave alternans and atrioventricular block: three consecutive rate-dependent phenomena in a child with congenital long-QT syndrome.
Kenttä T, Tulppo MP, Nearing BD, Karjalainen JJ, Hautala AJ, Kiviniemi AM, Huikuri HV, Verrier RL
Effects of exercise rehabilitation on cardiac electrical instability assessed by T-wave alternans during ambulatory electrocardiogram monitoring in coronary artery disease patients without and with diabetes mellitus. Am J Cardiol. 2014 Sep 15; 114(6):832-7.
Effects of exercise rehabilitation on cardiac electrical instability assessed by T-wave alternans during ambulatory electrocardiogram monitoring in coronary artery disease patients without and with diabetes mellitus.
Uchimura-Makita Y, Nakano Y, Tokuyama T, Fujiwara M, Watanabe Y, Sairaku A, Kawazoe H, Matsumura H, Oda N, Ikanaga H, Motoda C, Kajihara K, Oda N, Verrier RL, Kihara Y
Time-domain T-wave alternans is strongly associated with a history of ventricular fibrillation in patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2014 Sep; 25(9):1021-1027.
Time-domain T-wave alternans is strongly associated with a history of ventricular fibrillation in patients with Brugada syndrome.
Bonatti R, Silva AF, Batatinha JA, Sobrado LF, Machado AD, Varone BB, Nearing BD, Belardinelli L, Verrier RL
Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneity. Heart Rhythm. 2014 Oct; 11(10):1827-35.
Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneity.
Verrier RL, Bonatti R, Silva AF, Batatinha JA, Nearing BD, Liu G, Rajamani S, Zeng D, Belardinelli L
If inhibition in the atrioventricular node by ivabradine causes rate-dependent slowing of conduction and reduces ventricular rate during atrial fibrillation. Heart Rhythm. 2014 Dec; 11(12):2288-96.
If inhibition in the atrioventricular node by ivabradine causes rate-dependent slowing of conduction and reduces ventricular rate during atrial fibrillation.
Schomer AC, Nearing BD, Schachter SC, Verrier RL
Vagus nerve stimulation reduces cardiac electrical instability assessed by quantitative T-wave alternans analysis in patients with drug-resistant focal epilepsy. Epilepsia. 2014 Dec; 55(12):1996-2002.
Vagus nerve stimulation reduces cardiac electrical instability assessed by quantitative T-wave alternans analysis in patients with drug-resistant focal epilepsy.
Takasugi N, Goto H, Kuwahara T, Verrier RL
Sudden paradoxical QT-interval prolongation exacerbating T-wave alternans in a patient with type 3 long QT syndrome. Ann Noninvasive Electrocardiol. 2015 May; 20(3):290-1.
Sudden paradoxical QT-interval prolongation exacerbating T-wave alternans in a patient with type 3 long QT syndrome.
Quantitative T-wave alternans analysis for guiding medical therapy: an underexploited opportunity. Trends Cardiovasc Med. 2015 Apr; 25(3):201-13.
Quantitative T-wave alternans analysis for guiding medical therapy: an underexploited opportunity.
Verrier RL, Silva AF, Bonatti R, Batatinha JA, Nearing BD, Liu G, Rajamani S, Zeng D, Belardinelli L
Combined actions of ivabradine and ranolazine reduce ventricular rate during atrial fibrillation. J Cardiovasc Electrophysiol. 2015 Mar; 26(3):329-35.
Combined actions of ivabradine and ranolazine reduce ventricular rate during atrial fibrillation.
Multilead template-derived residua of surface ECGS for quantitative assessment of arrhythmia risk. Ann Noninvasive Electrocardiol. 2015 May; 20(3):273-81.
Multilead template-derived residua of surface ECGS for quantitative assessment of arrhythmia risk.
Minkkinen M, Nieminen T, Verrier RL, Leino J, Lehtimäki T, Viik J, Lehtinen R, Nikus K, Kööbi T, Turjanmaa V, Kähönen M
European journal of preventive cardiology
Prognostic capacity of a clinically indicated exercise test for cardiovascular mortality is enhanced by combined analysis of exercise capacity, heart rate recovery and T-wave alternans. Eur J Prev Cardiol. 2015 Sep; 22(9):1162-70.
Prognostic capacity of a clinically indicated exercise test for cardiovascular mortality is enhanced by combined analysis of exercise capacity, heart rate recovery and T-wave alternans.
What can mechanics teach electricians about arrhythmias in heart failure? Heart Rhythm. 2015 Oct; 12(10):2184-5.
What can mechanics teach electricians about arrhythmias in heart failure?
Alves Bento AS, Bacic D, Saran Carneiro J, Nearing BD, Fuller H, Justo FA, Rajamani S, Belardinelli L, Verrier RL
Selective late INa inhibition by GS-458967 exerts parallel suppression of catecholamine-induced hemodynamically significant ventricular tachycardia and T-wave alternans in an intact porcine model. Heart Rhythm. 2015 Dec; 12(12):2508-14.
Selective late INa inhibition by GS-458967 exerts parallel suppression of catecholamine-induced hemodynamically significant ventricular tachycardia and T-wave alternans in an intact porcine model.
Carneiro JS, Bento AS, Bacic D, Nearing BD, Rajamani S, Belardinelli L, Verrier RL
The Selective Cardiac Late Sodium Current Inhibitor GS-458967 Suppresses Autonomically Triggered Atrial Fibrillation in an Intact Porcine Model. J Cardiovasc Electrophysiol. 2015 Dec; 26(12):1364-9.
The Selective Cardiac Late Sodium Current Inhibitor GS-458967 Suppresses Autonomically Triggered Atrial Fibrillation in an Intact Porcine Model.
Chemical Cardioversion of Atrial Fibrillation by Transatrial Delivery of Antiarrhythmic Agents into the Pericardial Space
A Novel Approach for Prevention and Treatment of Atrial Fibrillation by Intrapericardial L-Arginine Administration
Mewton N, Strauss DG, Rizzi P, Verrier RL, Liu CY, Tereshchenko LG, Nearing B, Volpe GJ, Marchlinski FE, Moxley J, Killian T, Wu KC, Spooner P, Lima JA
Screening for Cardiac Magnetic Resonance Scar Features by 12-Lead ECG, in Patients with Preserved Ejection Fraction. Ann Noninvasive Electrocardiol. 2016 Jan; 21(1):49-59.
Screening for Cardiac Magnetic Resonance Scar Features by 12-Lead ECG, in Patients with Preserved Ejection Fraction.
Takasugi N, Goto H, Takasugi M, Verrier RL, Kuwahara T, Kubota T, Toyoshi H, Nakashima T, Kawasaki M, Nishigaki K, Minatoguchi S
Prevalence of Microvolt T-Wave Alternans in Patients With Long QT Syndrome and Its Association With Torsade de Pointes. Circ Arrhythm Electrophysiol. 2016 Feb; 9(2):e003206.
Prevalence of Microvolt T-Wave Alternans in Patients With Long QT Syndrome and Its Association With Torsade de Pointes.
Libbus I, Nearing BD, Amurthur B, KenKnight BH, Verrier RL
Autonomic regulation therapy suppresses quantitative T-wave alternans and improves baroreflex sensitivity in patients with heart failure enrolled in the ANTHEM-HF study. Heart Rhythm. 2016 Mar; 13(3):721-8.
Autonomic regulation therapy suppresses quantitative T-wave alternans and improves baroreflex sensitivity in patients with heart failure enrolled in the ANTHEM-HF study.
Kenttä TV, Nearing BD, Porthan K, Tikkanen JT, Viitasalo M, Nieminen MS, Salomaa V, Oikarinen L, Jula A, Kontula K, Newton-Cheh C, Huikuri HV, Verrier RL
Prediction of sudden cardiac death with automated high-throughput analysis of heterogeneity in standard resting 12-lead electrocardiograms. Heart Rhythm. 2016 Mar; 13(3):713-20.
Prediction of sudden cardiac death with automated high-throughput analysis of heterogeneity in standard resting 12-lead electrocardiograms.
Characterization of the Efficacy of Intrapericardially Delivered Autonomic Nerve Blocking Agents in Protection Against Ischemia/reperfusion-induced Arrhythmia in Pigs
Inhibition of Intracellular Calcium Overload by Intrapericardial Nitroglycerin as a Major Mechanism for Its Potent Antifibrillatory
Critical neurocircuitry mediating cardiovascular diseases and strategies for intervention. Trends Cardiovasc Med. 2016 Apr; 26(3):258-9.
Critical neurocircuitry mediating cardiovascular diseases and strategies for intervention.
Letter to the Editor--Can reducing quantitative T-wave alternans save lives? Heart Rhythm. 2016 Apr; 13(4):e89.
Letter to the Editor--Can reducing quantitative T-wave alternans save lives?
Verrier RL, Fuller H, Justo F, Nearing BD, Rajamani S, Belardinelli L
Unmasking atrial repolarization to assess alternans, spatiotemporal heterogeneity, and susceptibility to atrial fibrillation. Heart Rhythm. 2016 Apr; 13(4):953-61.
Unmasking atrial repolarization to assess alternans, spatiotemporal heterogeneity, and susceptibility to atrial fibrillation.
Hermodynamic and Electrophysiologic Effects of Intrapericardial Delivery of Vasodilators and Antiarrhythmics
Quantitative T-wave alternans analysis for sudden cardiac death risk assessment and guiding therapy: answered and unanswered questions: For: Proceedings of ICE2015 Comandatuba, Brazil, Sudden Death Symposium. J Electrocardiol. 2016 May-Jun; 49(3):429-38.
Quantitative T-wave alternans analysis for sudden cardiac death risk assessment and guiding therapy: answered and unanswered questions: For: Proceedings of ICE2015 Comandatuba, Brazil, Sudden Death Symposium.
Hemodynamic and Electrophysiologic Effects of Intrapericardial Delivery of Vasodilators and Antiarrhythmics FOR CREDIT ONLY
Fuller H, Justo F, Nearing BD, Kahlig KM, Rajamani S, Belardinelli L, Verrier RL
Eleclazine, a new selective cardiac late sodium current inhibitor, confers concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in an intact porcine model. Heart Rhythm. 2016 08; 13(8):1679-86.
Eleclazine, a new selective cardiac late sodium current inhibitor, confers concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in an intact porcine model.
Commentary: Sudden Cardiac Risk Stratification with Electrocardiographic Indices - A Review on Computational Processing, Technology Transfer, and Scientific Evidence. Front Physiol. 2016; 7:267.
Commentary: Sudden Cardiac Risk Stratification with Electrocardiographic Indices - A Review on Computational Processing, Technology Transfer, and Scientific Evidence.
Justo F, Fuller H, Nearing BD, Rajamani S, Belardinelli L, Verrier RL
Inhibition of the cardiac late sodium current with eleclazine protects against ischemia-induced vulnerability to atrial fibrillation and reduces atrial and ventricular repolarization abnormalities in the absence and presence of concurrent adrenergic stimulation. Heart Rhythm. 2016 09; 13(9):1860-7.
Inhibition of the cardiac late sodium current with eleclazine protects against ischemia-induced vulnerability to atrial fibrillation and reduces atrial and ventricular repolarization abnormalities in the absence and presence of concurrent adrenergic stimulation.
ANTIFIBRILLATORY MECHANISMS OF INTRAPERICARDIAL AGENTS
MECHANISMS OF MORBIDITY/MORTALITY DUE TO AIR PARTICLES
CORONARY CONSTRICTON AND BEHAVIORALLY INDUCED ARRHYTHMIA
DYNAMIC TRACKING OF CARDIAC ARRHYTHMOGENESIS IN SLEEP
STRESS, NEUROACTIVE PEPTIDES, AND CARDIAC ARRHYTHMIAS
EFFECT OF SLEEP ON MYCARDIAL PERFUSION AND ARRHYTHMIAS
Verrier RL, Nearing BD, Olin B, Boon P, Schachter SC
Baseline elevation and reduction in cardiac electrical instability assessed by quantitative T-wave alternans in patients with drug-resistant epilepsy treated with vagus nerve stimulation in the AspireSR E-36 trial. Epilepsy Behav. 2016 09; 62:85-9.
Baseline elevation and reduction in cardiac electrical instability assessed by quantitative T-wave alternans in patients with drug-resistant epilepsy treated with vagus nerve stimulation in the AspireSR E-36 trial.
Nearing BD, Libbus I, Amurthur B, Kenknight BH, Verrier RL
Acute Autonomic Engagement Assessed by Heart Rate Dynamics During Vagus Nerve Stimulation in Patients With Heart Failure in the ANTHEM-HF Trial. J Cardiovasc Electrophysiol. 2016 09; 27(9):1072-7.
Acute Autonomic Engagement Assessed by Heart Rate Dynamics During Vagus Nerve Stimulation in Patients With Heart Failure in the ANTHEM-HF Trial.
Bacic D, Carneiro JS, Bento AA, Nearing BD, Rajamani S, Belardinelli L, Verrier RL
Eleclazine, an inhibitor of the cardiac late sodium current, is superior to flecainide in suppressing catecholamine-induced ventricular tachycardia and T-wave alternans in an intact porcine model. Heart Rhythm. 2017 03; 14(3):448-454.
Eleclazine, an inhibitor of the cardiac late sodium current, is superior to flecainide in suppressing catecholamine-induced ventricular tachycardia and T-wave alternans in an intact porcine model.
Silva AF, Bonatti R, Batatinha JA, Nearing BD, Zeng D, Belardinelli L, Verrier RL
The Selective Late Sodium Current Inhibitor Eleclazine, Unlike Amiodarone, Does Not Alter Defibrillation Threshold or Dominant Frequency of Ventricular Fibrillation. J Cardiovasc Pharmacol. 2017 Mar; 69(3):178-182.
The Selective Late Sodium Current Inhibitor Eleclazine, Unlike Amiodarone, Does Not Alter Defibrillation Threshold or Dominant Frequency of Ventricular Fibrillation.
Kaplan RM, Herzog CA, Larive B, Subacius H, Nearing BD, Verrier R, Passman RS
T-Wave Alternans, Heart Rate Turbulence, and Ventricular Ectopy in Standard versus Daily Hemodialysis: Results from the FHN Daily Trial. Ann Noninvasive Electrocardiol. 2016 Nov; 21(6):566-571.
T-Wave Alternans, Heart Rate Turbulence, and Ventricular Ectopy in Standard versus Daily Hemodialysis: Results from the FHN Daily Trial.
Carlson GM, Libbus I, Amurthur B, KenKnight BH, Verrier RL
Novel method to assess intrinsic heart rate recovery in ambulatory ECG recordings tracks cardioprotective effects of chronic autonomic regulation therapy in patients enrolled in the ANTHEM-HF study. Ann Noninvasive Electrocardiol. 2017 Sep; 22(5).
Novel method to assess intrinsic heart rate recovery in ambulatory ECG recordings tracks cardioprotective effects of chronic autonomic regulation therapy in patients enrolled in the ANTHEM-HF study.
Potent antifibrillatory effect of combined blockade of calcium channels and 5-HT2 receptors with nexopamil during myocardial ischemia and reperfusion in dogs: comparison to diltiazem. J Cardiovasc Pharmacol. 1996 Jun; 27(6):777-87.
Potent antifibrillatory effect of combined blockade of calcium channels and 5-HT2 receptors with nexopamil during myocardial ischemia and reperfusion in dogs: comparison to diltiazem.
Complex oscillatory heart rhythm: a dance macabre. J Clin Invest. 1997 Jan 15; 99(2):156-7.
Complex oscillatory heart rhythm: a dance macabre.
Verrier RL, Waxman S, Lovett EG, Moreno R
Transatrial access to the normal pericardial space: a novel approach for diagnostic sampling, pericardiocentesis, and therapeutic interventions. Circulation. 1998 Nov 24; 98(21):2331-3.
Transatrial access to the normal pericardial space: a novel approach for diagnostic sampling, pericardiocentesis, and therapeutic interventions.
de Oliveira Antunes M, Samesima N, Pereira Filho HG, Matsumoto AY, Verrier RL, Pastore CA, Arteaga-Fernández E, Mady C
Exercise-induced quantitative microvolt T-wave alternans in hypertrophic cardiomyopathy. J Electrocardiol. 2017 Mar - Apr; 50(2):184-190.
Exercise-induced quantitative microvolt T-wave alternans in hypertrophic cardiomyopathy.
Persistent primary coronary dilation induced by transatrial delivery of nitroglycerin into the pericardial space: a novel approach for local cardiac drug delivery. J Am Coll Cardiol. 1999 Jun; 33(7):2073-7.
Persistent primary coronary dilation induced by transatrial delivery of nitroglycerin into the pericardial space: a novel approach for local cardiac drug delivery.
Exercise stress testing for T wave alternans to expose latent electrical instability. J Cardiovasc Electrophysiol. 1997 Sep; 8(9):994-7.
Exercise stress testing for T wave alternans to expose latent electrical instability.
Pope CA, Eatough DJ, Gold DR, Pang Y, Nielsen KR, Nath P, Verrier RL, Kanner RE
Acute exposure to environmental tobacco smoke and heart rate variability. Environ Health Perspect. 2001 Jul; 109(7):711-6.
Acute exposure to environmental tobacco smoke and heart rate variability.
Tracking cardiac electrical instability by computing interlead heterogeneity of T-wave morphology. J Appl Physiol (1985). 2003 Dec; 95(6):2265-72.
Tracking cardiac electrical instability by computing interlead heterogeneity of T-wave morphology.
Porter JM, Ivatury RR, Kavarana M, Verrier R
The surgical intensive care unit as a cost-efficient substitute for an operating room at a Level I trauma center. Am Surg. 1999 Apr; 65(4):328-30.
The surgical intensive care unit as a cost-efficient substitute for an operating room at a Level I trauma center.
T-Wave alternans for arrhythmia risk stratification in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol. 2003 Jun 18; 41(12):2225-7.
T-Wave alternans for arrhythmia risk stratification in patients with idiopathic dilated cardiomyopathy.
Analysis of complex T-wave oscillations for prediction of ventricular fibrillation. J Electrocardiol. 2003; 36 Suppl:199-203.
Analysis of complex T-wave oscillations for prediction of ventricular fibrillation.
Gold DR, Litonjua AA, Zanobetti A, Coull BA, Schwartz J, MacCallum G, Verrier RL, Nearing BD, Canner MJ, Suh H, Stone PH
Air pollution and ST-segment depression in elderly subjects. Environ Health Perspect. 2005 Jul; 113(7):883-7.
Air pollution and ST-segment depression in elderly subjects.
Pacing and clinical electrophysiology : PACE
Behavioral states and sudden cardiac death. Pacing Clin Electrophysiol. 1992 Sep; 15(9):1387-93.
Behavioral states and sudden cardiac death.
Rowe K, Moreno R, Lau TR, Wallooppillai U, Nearing BD, Kocsis B, Quattrochi J, Hobson JA, Verrier RL
Heart rate surges during REM sleep are associated with theta rhythm and PGO activity in cats. Am J Physiol. 1999 09; 277(3):R843-9.
Heart rate surges during REM sleep are associated with theta rhythm and PGO activity in cats.
Progressive increases in complexity of T-wave oscillations herald ischemia-induced ventricular fibrillation. Circ Res. 2002 Oct 18; 91(8):727-32.
Progressive increases in complexity of T-wave oscillations herald ischemia-induced ventricular fibrillation.
Verrier RL, Lau TR, Wallooppillai U, Quattrochi J, Nearing BD, Moreno R, Hobson JA
Primary vagally mediated decelerations in heart rate during tonic rapid eye movement sleep in cats. Am J Physiol. 1998 04; 274(4):R1136-41.
Primary vagally mediated decelerations in heart rate during tonic rapid eye movement sleep in cats.
Differential effects of sleep stage on coronary hemodynamic function. Am J Physiol. 1989 May; 256(5 Pt 2):H1378-83.
Differential effects of sleep stage on coronary hemodynamic function.
Role of the autonomic nervous system in sudden death. Cardiovasc Clin. 1985; 15(3):41-63.
Role of the autonomic nervous system in sudden death.
Optimizing ambulatory ECG monitoring of T-wave alternans for arrhythmia risk assessment. Card Electrophysiol Rev. 2002 Sep; 6(3):329-33.
Optimizing ambulatory ECG monitoring of T-wave alternans for arrhythmia risk assessment.
Bartoli CR, Akiyama I, Godleski JJ, Verrier RL
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Long-term pericardial catheterization is associated with minimum foreign-body response. Catheter Cardiovasc Interv. 2007 Aug 01; 70(2):221-7.
Long-term pericardial catheterization is associated with minimum foreign-body response.
Kumar K, Nguyen K, Waxman S, Nearing BD, Wellenius GA, Zhao SX, Verrier RL
Potent antifibrillatory effects of intrapericardial nitroglycerin in the ischemic porcine heart. J Am Coll Cardiol. 2003 May 21; 41(10):1831-7.
Potent antifibrillatory effects of intrapericardial nitroglycerin in the ischemic porcine heart.
Pulerwitz TC, Waxman S, Rowe KA, Quist WC, Lipinska I, Verrier RL
Transatrial access to the normal pericardial space for local cardiac therapy: preclinical safety testing with aspirin and pulmonary artery hypertension. J Interv Cardiol. 2001 Oct; 14(5):493-8.
Transatrial access to the normal pericardial space for local cardiac therapy: preclinical safety testing with aspirin and pulmonary artery hypertension.
Steinberg JS, Varma N, Cygankiewicz I, Aziz P, Balsam P, Baranchuk A, Cantillon DJ, Dilaveris P, Dubner SJ, El-Sherif N, Krol J, Kurpesa M, La Rovere MT, Lobodzinski SS, Locati ET, Mittal S, Olshansky B, Piotrowicz E, Saxon L, Stone PH, Tereshchenko L, Turitto G, Wimmer NJ, Verrier RL, Zareba W, Piotrowicz R
2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry. Heart Rhythm. 2017 07; 14(7):e55-e96.
2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry.
Steinberg JS, Varma N, Cygankiewicz I, Aziz P, Balsam P, Baranchuk A, Cantillon DJ, Dilaveris P, Dubner SJ, El-Sherif N, Krol J, Kurpesa M, La Rovere MT, Lobodzinski SS, Locati ET, Mittal S, Olshansky B, Piotrowicz E, Saxon L, Stone PH, Tereshchenko L, Turakhia MP, Turitto G, Wimmer NJ, Verrier RL, Zareba W, Piotrowicz R
2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry. Ann Noninvasive Electrocardiol. 2017 05; 22(3).
The enigmatic cardiac fat pads: critical but underappreciated neural regulatory sites. J Cardiovasc Electrophysiol. 2002 Sep; 13(9):902-3.
The enigmatic cardiac fat pads: critical but underappreciated neural regulatory sites.
Impact of sleep on arrhythmogenesis. Circ Arrhythm Electrophysiol. 2009 Aug; 2(4):450-9.
Carvas M, Nascimento BC, Acar M, Nearing BD, Belardinelli L, Verrier RL
Intrapericardial ranolazine prolongs atrial refractory period and markedly reduces atrial fibrillation inducibility in the intact porcine heart. J Cardiovasc Pharmacol. 2010 Mar; 55(3):286-91.
Intrapericardial ranolazine prolongs atrial refractory period and markedly reduces atrial fibrillation inducibility in the intact porcine heart.
Ambulatory ECG monitoring of T-wave alternans for arrhythmia risk assessment. J Electrocardiol. 2003; 36 Suppl:193-7.
Ambulatory ECG monitoring of T-wave alternans for arrhythmia risk assessment.
Air pollution: small particles, big problems? Epidemiology. 2003 Sep; 14(5):512-3.
Air pollution: small particles, big problems?
Dockery DW, Luttmann-Gibson H, Rich DQ, Link MS, Mittleman MA, Gold DR, Koutrakis P, Schwartz JD, Verrier RL
Association of air pollution with increased incidence of ventricular tachyarrhythmias recorded by implanted cardioverter defibrillators. Environ Health Perspect. 2005 Jun; 113(6):670-4.
Association of air pollution with increased incidence of ventricular tachyarrhythmias recorded by implanted cardioverter defibrillators.
Neurochemical approaches to the prevention of ventricular fibrillation. Fed Proc. 1986 Jul; 45(8):2191-6.
Neurochemical approaches to the prevention of ventricular fibrillation.
Nieminen T, Lehtimäki T, Viik J, Lehtinen R, Nikus K, Kööbi T, Niemelä K, Turjanmaa V, Kaiser W, Huhtala H, Verrier RL, Huikuri H, Kähönen M
T-wave alternans predicts mortality in a population undergoing a clinically indicated exercise test. Eur Heart J. 2007 Oct; 28(19):2332-7.
T-wave alternans predicts mortality in a population undergoing a clinically indicated exercise test.
Tracking interlead heterogeneity of R- and T-wave morphology to disclose latent risk for sudden cardiac death. Heart Rhythm. 2017 10; 14(10):1466-1475.
Tracking interlead heterogeneity of R- and T-wave morphology to disclose latent risk for sudden cardiac death.
Statins protect against arrhythmogenic calcium alternans in the post-myocardial infarction diabetic heart: Pleiotropy on steroids. Heart Rhythm. 2017 09; 14(9):1417-1418.
Statins protect against arrhythmogenic calcium alternans in the post-myocardial infarction diabetic heart: Pleiotropy on steroids.
The atrial neural network: Ablation minefield or strategic target? Heart Rhythm. 2007 Jan; 4(1):64-5.
The atrial neural network: Ablation minefield or strategic target?
Lavery CE, Mittleman MA, Cohen MC, Muller JE, Verrier RL
Nonuniform nighttime distribution of acute cardiac events: a possible effect of sleep states. Circulation. 1997 Nov 18; 96(10):3321-7.
Nonuniform nighttime distribution of acute cardiac events: a possible effect of sleep states.
Quantitative evaluation of heartbeat interval time series using Poincaré analysis reveals distinct patterns of heart rate dynamics during cycles of vagus nerve stimulation in patients with heart failure. J Electrocardiol. 2017 Nov - Dec; 50(6):898-903.
Quantitative evaluation of heartbeat interval time series using Poincaré analysis reveals distinct patterns of heart rate dynamics during cycles of vagus nerve stimulation in patients with heart failure.
Predicting cardiac resynchronization therapy response based on endothelial dysfunction: causal link or fellow traveler? Heart Rhythm. 2008 Sep; 5(9):1236-7.
Predicting cardiac resynchronization therapy response based on endothelial dysfunction: causal link or fellow traveler?
Modified moving average analysis of T-wave alternans to predict ventricular fibrillation with high accuracy. J Appl Physiol (1985). 2002 Feb; 92(2):541-9.
Modified moving average analysis of T-wave alternans to predict ventricular fibrillation with high accuracy.
Evaristo E, Stocco FG, Shah NR, Cheezum MK, Hainer J, Foster C, Nearing BD, Di Carli M, Verrier RL
Ranolazine reduces repolarization heterogeneity in symptomatic patients with diabetes and non-flow-limiting coronary artery stenosis. Ann Noninvasive Electrocardiol. 2018 Jan; 23(1).
Ranolazine reduces repolarization heterogeneity in symptomatic patients with diabetes and non-flow-limiting coronary artery stenosis.
Effect of vagus nerve stimulation upon excitability of the canine ventricle. Role of sympathetic-parasympathetic interactions. Am J Cardiol. 1976 Jun; 37(7):1041-5.
Effect of vagus nerve stimulation upon excitability of the canine ventricle. Role of sympathetic-parasympathetic interactions.
Saini V, Carr DB, Hagestad EL, Lown B, Verrier RL
Antifibrillatory action of the narcotic agonist fentanyl. Am Heart J. 1988 Mar; 115(3):598-605.
Antifibrillatory action of the narcotic agonist fentanyl.
Tan AY, Nearing BD, Rosenberg M, Nezafat R, Josephson ME, Verrier RL
Interlead heterogeneity of R- and T-wave morphology in standard 12-lead ECGs predicts sustained ventricular tachycardia/fibrillation and arrhythmic death in patients with cardiomyopathy. J Cardiovasc Electrophysiol. 2017 Nov; 28(11):1324-1333.
Interlead heterogeneity of R- and T-wave morphology in standard 12-lead ECGs predicts sustained ventricular tachycardia/fibrillation and arrhythmic death in patients with cardiomyopathy.
Electrophysiologic basis for T wave alternans as an index of vulnerability to ventricular fibrillation. J Cardiovasc Electrophysiol. 1994 May; 5(5):445-61.
Electrophysiologic basis for T wave alternans as an index of vulnerability to ventricular fibrillation.
Effect of nitroglycerin on vulnerability to ventricular fibrillation during myocardial ischemia and reperfusion. Am J Cardiol. 1979 Feb; 43(2):233-8.
Effect of nitroglycerin on vulnerability to ventricular fibrillation during myocardial ischemia and reperfusion.
Bartoli CR, Wellenius GA, Diaz EA, Lawrence J, Coull BA, Akiyama I, Lee LM, Okabe K, Verrier RL, Godleski JJ
Mechanisms of inhaled fine particulate air pollution-induced arterial blood pressure changes. Environ Health Perspect. 2009 Mar; 117(3):361-6.
Mechanisms of inhaled fine particulate air pollution-induced arterial blood pressure changes.
Letter by De Ferrari and Verrier regarding article, "Role of microvolt T-wave alternans in assessment of arrhythmia vulnerability among patients with heart failure and systolic dysfunction: primary results from the T-wave alternans sudden cardiac death in heart failure trial substudy". Circulation. 2009 Jul 21; 120(3):e20; author reply e22.
Letter by De Ferrari and Verrier regarding article, "Role of microvolt T-wave alternans in assessment of arrhythmia vulnerability among patients with heart failure and systolic dysfunction: primary results from the T-wave alternans sudden cardiac death in heart failure trial substudy".
T-wave alternans as a therapeutic marker for antiarrhythmic agents. J Cardiovasc Pharmacol. 2010 Jun; 55(6):544-54.
T-wave alternans as a therapeutic marker for antiarrhythmic agents.
The effect of vagus nerve stimulation upon vulnerability of the canine ventricle: role of sympathetic-parasympathetic interactions. Circulation. 1975 Oct; 52(4):578-85.
The effect of vagus nerve stimulation upon vulnerability of the canine ventricle: role of sympathetic-parasympathetic interactions.
Computer-aided visualization of microvolt T-wave alternans: "seeing is believing". J Cardiovasc Electrophysiol. 2008 Sep; 19(9):E51-2.
Computer-aided visualization of microvolt T-wave alternans: "seeing is believing".
Heart rate, autonomic markers, and cardiac mortality. Heart Rhythm. 2009 Nov; 6(11 Suppl):S68-75.
Heart rate, autonomic markers, and cardiac mortality.
Secemsky EA, Verrier RL, Cooke G, Ghossein C, Subacius H, Manuchehry A, Herzog CA, Passman R
High prevalence of cardiac autonomic dysfunction and T-wave alternans in dialysis patients. Heart Rhythm. 2011 Apr; 8(4):592-8.
High prevalence of cardiac autonomic dysfunction and T-wave alternans in dialysis patients.
Influence of beta 2-adrenoceptor stimulation and blockade on cardiac electrophysiologic properties and serum potassium concentration in the anesthetized dog. Am Heart J. 1987 May; 113(5):1066-70.
Influence of beta 2-adrenoceptor stimulation and blockade on cardiac electrophysiologic properties and serum potassium concentration in the anesthetized dog.
Editorial Commentary: Tuning in to sympathetic activity cutaneously in humans-A bench to bedside saga. Trends Cardiovasc Med. 2017 10; 27(7):473-474.
Editorial Commentary: Tuning in to sympathetic activity cutaneously in humans-A bench to bedside saga.
Nieminen T, Verrier RL, Leino J, Nikus K, Lehtinen R, Lehtimäki T, Minkkinen M, Kööbi T, Turjanmaa V, Viik J, Kähönen M
Atrioventricular conduction and cardiovascular mortality: assessment of recovery PR interval is superior to pre-exercise measurement. Heart Rhythm. 2010 Jun; 7(6):796-801.
Atrioventricular conduction and cardiovascular mortality: assessment of recovery PR interval is superior to pre-exercise measurement.
Muscarinic effects of vagosympathetic trunk stimulation on the repetitive extrasystole (RE) threshold. Circulation. 1976 Apr; 53(4):622-7.
Muscarinic effects of vagosympathetic trunk stimulation on the repetitive extrasystole (RE) threshold.
Psychological stress and ventricular arrhythmias during myocardial infarction in the conscious dog. Am J Cardiol. 1974 Nov; 34(6):692-6.
Psychological stress and ventricular arrhythmias during myocardial infarction in the conscious dog.
Effect of stellectomy and vagotomy on ventricular refractoriness in dogs. Circ Res. 1977 Jun; 40(6):536-40.
Effect of stellectomy and vagotomy on ventricular refractoriness in dogs.
Hull SS, Vanoli E, Adamson PB, Verrier RL, Foreman RD, Schwartz PJ
Exercise training confers anticipatory protection from sudden death during acute myocardial ischemia. Circulation. 1994 Feb; 89(2):548-52.
Exercise training confers anticipatory protection from sudden death during acute myocardial ischemia.
Wellenius GA, Saldiva PH, Batalha JR, Krishna Murthy GG, Coull BA, Verrier RL, Godleski JJ
Electrocardiographic changes during exposure to residual oil fly ash (ROFA) particles in a rat model of myocardial infarction. Toxicol Sci. 2002 Apr; 66(2):327-35.
Electrocardiographic changes during exposure to residual oil fly ash (ROFA) particles in a rat model of myocardial infarction.
Air pollution: an insidious and pervasive component of cardiac risk. Circulation. 2002 Aug 20; 106(8):890-2.
Air pollution: an insidious and pervasive component of cardiac risk.
Zhao SX, Lee LM, Nearing BD, Busso VO, Kwaku KF, Verrier RL
Suppression of calcium-induced repolarization heterogeneity as a mechanism of nitroglycerin's antiarrhythmic action. J Cardiovasc Pharmacol. 2006 Aug; 48(2):22-9.
Suppression of calcium-induced repolarization heterogeneity as a mechanism of nitroglycerin's antiarrhythmic action.
Bartoli CR, Wellenius GA, Coull BA, Akiyama I, Diaz EA, Lawrence J, Okabe K, Verrier RL, Godleski JJ
Concentrated ambient particles alter myocardial blood flow during acute ischemia in conscious canines. Environ Health Perspect. 2009 Mar; 117(3):333-7.
Concentrated ambient particles alter myocardial blood flow during acute ischemia in conscious canines.
Shlapakova IN, Nearing BD, Lau DH, Boink GJ, Danilo P, Kryukova Y, Robinson RB, Cohen IS, Rosen MR, Verrier RL
Biological pacemakers in canines exhibit positive chronotropic response to emotional arousal. Heart Rhythm. 2010 Dec; 7(12):1835-40.
Biological pacemakers in canines exhibit positive chronotropic response to emotional arousal.
Stocco FG, Evaristo E, Shah NR, Cheezum MK, Hainer J, Foster C, Nearing BD, Gervino E, Verrier RL
Marked exercise-induced T-wave heterogeneity in symptomatic diabetic patients with nonflow-limiting coronary artery stenosis. Ann Noninvasive Electrocardiol. 2018 Mar; 23(2):e12503.
Marked exercise-induced T-wave heterogeneity in symptomatic diabetic patients with nonflow-limiting coronary artery stenosis.
Rotenberg FA, Verrier RL, Lown B, Sole MJ
Effects of clonidine on vulnerability to fibrillation in the normal and ischemic canine ventricle. Eur J Pharmacol. 1978 Jan 01; 47(1):71-9.
Effects of clonidine on vulnerability to fibrillation in the normal and ischemic canine ventricle.
Protective effect of the vagotonic action of morphine sulphate on ventricular vulnerability. Cardiovasc Res. 1978 Mar; 12(3):167-72.
Protective effect of the vagotonic action of morphine sulphate on ventricular vulnerability.
Quantification of ischaemia induced vulnerability by precordial T wave alternans analysis in dog and human. Cardiovasc Res. 1994 Sep; 28(9):1440-9.
Quantification of ischaemia induced vulnerability by precordial T wave alternans analysis in dog and human.
Autonomic nervous system and coronary blood flow changes related to emotional activation and sleep. Circulation. 1991 Apr; 83(4 Suppl):II81-9.
Autonomic nervous system and coronary blood flow changes related to emotional activation and sleep.
Beta3-adrenoceptor: friend or foe? Heart Rhythm. 2005 Dec; 2(12):1356-8.
Noninvasive sudden death risk stratification by ambulatory ECG-based T-wave alternans analysis: evidence and methodological guidelines. Ann Noninvasive Electrocardiol. 2005 Jan; 10(1):110-20.
Noninvasive sudden death risk stratification by ambulatory ECG-based T-wave alternans analysis: evidence and methodological guidelines.
Re: Time-domain T-wave alternans measured from Holter electrocardiograms predicts cardiac mortality in patients with left ventricular dysfunction: a prospective study. Heart Rhythm. 2009 Apr; 6(4):e1; author reply e1.
Re: Time-domain T-wave alternans measured from Holter electrocardiograms predicts cardiac mortality in patients with left ventricular dysfunction: a prospective study.
Acute effects of carbon monoxide on cardiac electrical stability. Res Rep Health Eff Inst. 1990 Oct; (35):1-14.
Acute effects of carbon monoxide on cardiac electrical stability.
The impact of emotions on the heart. Prog Brain Res. 2000; 122:369-80.
Waxman S, Pulerwitz TC, Rowe KA, Quist WC, Verrier RL
Preclinical safety testing of percutaneous transatrial access to the normal pericardial space for local cardiac drug delivery and diagnostic sampling. Catheter Cardiovasc Interv. 2000 Apr; 49(4):472-7.
Preclinical safety testing of percutaneous transatrial access to the normal pericardial space for local cardiac drug delivery and diagnostic sampling.
Godleski JJ, Verrier RL, Koutrakis P, Catalano P, Coull B, Reinisch U, Lovett EG, Lawrence J, Murthy GG, Wolfson JM, Clarke RW, Nearing BD, Killingsworth C
Mechanisms of morbidity and mortality from exposure to ambient air particles. Res Rep Health Eff Inst. 2000 Feb; (91):5-88; discussion 89-103.
Mechanisms of morbidity and mortality from exposure to ambient air particles.
Quattrochi JJ, Shapiro J, Verrier RL, Hobson JA
Transient cardiorespiratory events during NREM sleep: a feline model for human microarousals. J Sleep Res. 2000 Jun; 9(2):185-91.
Transient cardiorespiratory events during NREM sleep: a feline model for human microarousals.
Kawaguchi T, Takasugi N, Kubota T, Takasugi M, Kanamori H, Ushikoshi H, Hattori A, Aoyama T, Kawasaki M, Nishigaki K, Takemura G, Minatoguchi S, Verrier RL
In-hospital monitoring of T-wave alternans in a case of amiodarone-induced torsade de pointes: clinical and methodologic insights. Europace. 2012 Sep; 14(9):1372-4.
In-hospital monitoring of T-wave alternans in a case of amiodarone-induced torsade de pointes: clinical and methodologic insights.
Bartoli CR, Okabe K, Akiyama I, Verrier RL, Godleski JJ
Journal of investigative surgery : the official journal of the Academy of Surgical Research
Technique for implantation of chronic indwelling aortic access catheters. J Invest Surg. 2006 Nov-Dec; 19(6):397-405.
Technique for implantation of chronic indwelling aortic access catheters.
Boink GJ, Nearing BD, Shlapakova IN, Duan L, Kryukova Y, Bobkov Y, Tan HL, Cohen IS, Danilo P, Robinson RB, Verrier RL, Rosen MR
Ca(2+)-stimulated adenylyl cyclase AC1 generates efficient biological pacing as single gene therapy and in combination with HCN2. Circulation. 2012 Jul 31; 126(5):528-36.
Ca(2+)-stimulated adenylyl cyclase AC1 generates efficient biological pacing as single gene therapy and in combination with HCN2.
Manuck SB, Henry JP, Anderson DE, Clarkson TB, Folkow B, Kaplan JR, Kaufmann PG, Lown B, Verrier RL
Biobehavioral mechanisms in coronary artery disease. Chronic stress. Circulation. 1987 Jul; 76(1 Pt 2):I158-63.
Biobehavioral mechanisms in coronary artery disease. Chronic stress.
Coronary distending pressure and delayed myocardial ischemia. Am Heart J. 1988 Jul; 116(1 Pt 1):59-66.
Coronary distending pressure and delayed myocardial ischemia.
Protective effect of tiapamil against ventricular fibrillation during coronary artery occlusion. Am Heart J. 1986 May; 111(5):878-82.
Protective effect of tiapamil against ventricular fibrillation during coronary artery occlusion.
Evans blue dye and the development of "myogenic tone" in perfused resistance vessels. Proc Soc Exp Biol Med. 1971 Jul; 137(3):1013-5.
Evans blue dye and the development of "myogenic tone" in perfused resistance vessels.
Decreased vulnerability to ventricular fibrillation by vasodilator-induced baroreceptor sensitisation. Cardiovasc Res. 1983 Feb; 17(2):106-12.
Decreased vulnerability to ventricular fibrillation by vasodilator-induced baroreceptor sensitisation.
Verrier RL, Kumar K, Nieminen T, Belardinelli L
Mechanisms of ranolazine's dual protection against atrial and ventricular fibrillation. Europace. 2013 Mar; 15(3):317-24.
Mechanisms of ranolazine's dual protection against atrial and ventricular fibrillation.
Noninvasive arrhythmia risk assessment in guiding pharmacologic therapy for prevention of sudden cardiac death: where do we stand? Where do we go? J Cardiovasc Pharmacol. 2010 May; 55(5):425-7.
Noninvasive arrhythmia risk assessment in guiding pharmacologic therapy for prevention of sudden cardiac death: where do we stand? Where do we go?
Effects of adrenergic and muscarinic receptor stimulation on serum potassium concentrations and myocardial electrical stability. Cardiovasc Res. 1986 Dec; 20(12):891-6.
Effects of adrenergic and muscarinic receptor stimulation on serum potassium concentrations and myocardial electrical stability.
Lehnert H, Lombardi F, Raeder EA, Lorenzo AV, Verrier RL, Lown B, Wurtman RJ
Increased release of brain serotonin reduces vulnerability to ventricular fibrillation in the cat. J Cardiovasc Pharmacol. 1987 Oct; 10(4):389-97.
Increased release of brain serotonin reduces vulnerability to ventricular fibrillation in the cat.
Leino J, Verrier RL, Minkkinen M, Lehtimäki T, Viik J, Lehtinen R, Nikus K, Kööbi T, Turjanmaa V, Kähönen M, Nieminen T
Importance of regional specificity of T-wave alternans in assessing risk for cardiovascular mortality and sudden cardiac death during routine exercise testing. Heart Rhythm. 2011 Mar; 8(3):385-90.
Importance of regional specificity of T-wave alternans in assessing risk for cardiovascular mortality and sudden cardiac death during routine exercise testing.
Nieminen T, Nanbu DY, Datti IP, Vaz GR, Tavares CA, Pegler JR, Nearing BD, Belardinelli L, Verrier RL
Antifibrillatory effect of ranolazine during severe coronary stenosis in the intact porcine model. Heart Rhythm. 2011 Apr; 8(4):608-14.
Antifibrillatory effect of ranolazine during severe coronary stenosis in the intact porcine model.
Nieminen T, Tavares CA, Pegler JR, Belardinelli L, Verrier RL
Circulation. Cardiovascular interventions
Ranolazine injection into coronary or femoral arteries exerts marked, transient regional vasodilation without systemic hypotension in an intact porcine model. Circ Cardiovasc Interv. 2011 Oct 01; 4(5):481-7.
Ranolazine injection into coronary or femoral arteries exerts marked, transient regional vasodilation without systemic hypotension in an intact porcine model.
Mechanisms of behaviorally induced arrhythmias. Circulation. 1987 Jul; 76(1 Pt 2):I48-56.
Mechanisms of behaviorally induced arrhythmias.
Neural activity and ventricular fibrillation. N Engl J Med. 1976 May 20; 294(21):1165-70.
Neural activity and ventricular fibrillation.
Delayed myocardial ischemia induced by anger. Circulation. 1987 Jan; 75(1):249-54.
Delayed myocardial ischemia induced by anger.
The Journal of pharmacology and experimental therapeutics
Effect of corticosteroids on the cardiovascular responses to angiotensin and norepinephrine. J Pharmacol Exp Ther. 1966 Oct; 154(1):83-91.
Effect of corticosteroids on the cardiovascular responses to angiotensin and norepinephrine.
Vagal modulation of epicardial coronary artery size in dogs. A two-dimensional intravascular ultrasound study. Circulation. 1995 Oct 15; 92(8):2291-8.
Vagal modulation of epicardial coronary artery size in dogs. A two-dimensional intravascular ultrasound study.
Dickerson LW, Huang AH, Thurnher MM, Nearing BD, Verrier RL
Relationship between coronary hemodynamic changes and the phasic events of rapid eye movement sleep. Sleep. 1993 Sep; 16(6):550-7.
Relationship between coronary hemodynamic changes and the phasic events of rapid eye movement sleep.
Life-threatening cardiovascular consequences of anger in patients with coronary heart disease. Cardiol Clin. 1996 May; 14(2):289-307.
Life-threatening cardiovascular consequences of anger in patients with coronary heart disease.
T-Wave variability, the new microvolt "buzz" in arrhythmia risk assessment: any links to TWA? J Cardiovasc Electrophysiol. 2011 Jul; 22(7):806-7.
T-Wave variability, the new microvolt "buzz" in arrhythmia risk assessment: any links to TWA?
Relationship between T-wave alternans magnitude and T-wave amplitude before the onset of ventricular tachyarrhythmias during emergent reperfusion in acute coronary syndrome patients. Europace. 2011 Oct; 13(10):1511-2; author reply 1512; discussion 1512-3.
Relationship between T-wave alternans magnitude and T-wave amplitude before the onset of ventricular tachyarrhythmias during emergent reperfusion in acute coronary syndrome patients.
Role of corticosteroids in the treatment of circulatory collapse states. Clin Pharmacol Ther. 1970 Sep-Oct; 11(5):630-55.
Role of corticosteroids in the treatment of circulatory collapse states.
Functional capacity of resistance and capacitance vessels in adrenal insufficiency. Am J Physiol. 1969 Aug; 217(2):341-7.
Functional capacity of resistance and capacitance vessels in adrenal insufficiency.
Reperfusion arrhythmias. Cardiovasc Res. 1993 Nov; 27(11):2082.
Impaired exercise capacity predicts sudden cardiac death in a low-risk population: enhanced specificity with heightened T-wave alternans. Ann Med. 2009; 41(5):380-9.
Impaired exercise capacity predicts sudden cardiac death in a low-risk population: enhanced specificity with heightened T-wave alternans.
Gleason JD, Nguyen KP, Kissinger KV, Manning WJ, Verrier RL
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
Myocardial drug distribution pattern following intrapericardial delivery: an MRI analysis. J Cardiovasc Magn Reson. 2002; 4(3):311-6.
Myocardial drug distribution pattern following intrapericardial delivery: an MRI analysis.
Cardiovascular consequences of anger and other stress states. Baillieres Clin Neurol. 1997 Jul; 6(2):245-59.
Cardiovascular consequences of anger and other stress states.
Boink GJ, Duan L, Nearing BD, Shlapakova IN, Sosunov EA, Anyukhovsky EP, Bobkov E, Kryukova Y, Ozgen N, Danilo P, Cohen IS, Verrier RL, Robinson RB, Rosen MR
HCN2/SkM1 gene transfer into canine left bundle branch induces stable, autonomically responsive biological pacing at physiological heart rates. J Am Coll Cardiol. 2013 Mar 19; 61(11):1192-201.
HCN2/SkM1 gene transfer into canine left bundle branch induces stable, autonomically responsive biological pacing at physiological heart rates.
Influence of glucose, insulin, and potassium on vulnerability to ventricular fibrillation in the canine heart. Circ Res. 1978 Oct; 43(4):601-8.
Influence of glucose, insulin, and potassium on vulnerability to ventricular fibrillation in the canine heart.
Sleep as an autonomic stress test for the heart. Ital Heart J. 2000 May; 1(5):329-30.
Sleep as an autonomic stress test for the heart.
Neural and psychologic mechanisms and the problem of sudden cardiac death. Am J Cardiol. 1977 May 26; 39(6):890-902.
Neural and psychologic mechanisms and the problem of sudden cardiac death.