MD165MinDongMin Dong, Ph.D.42.32602700000000-71.5001820000000012781Dong, Min857/218-4232Associate Professor of Surgerycatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idURLLinkvivo:webpagewebpagerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 10485201329396040Zhang S, Lebreton F, Mansfield MJ, Miyashita SI, Zhang J, Schwartzman JA, Tao L, Masuyer G, Martínez-Carranza M, Stenmark P, Gilmore MS, Doxey AC, Dong MCell host & microbeIdentification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium. Cell Host Microbe. 2018 Feb 14; 23(2):169-176.e6.Cell Host Microbe2018-01-27T00:00:002018Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium.2020-03-31DONG, MIN2018-04-01Molecular mechanism for retrograde transport of tetanus neurotoxinR21NS106159Principal InvestigatorLY111LinxiangYinLinxiang Yin, Ph.D.168433Yin, LinxiangResearch Fellow in Surgery2023-04-30DONG, MIN2018-05-15Structure and Function of C. Difficile ToxinsR01AI139087Principal Investigator23403573Peng L, Liu H, Ruan H, Tepp WH, Stoothoff WH, Brown RH, Johnson EA, Yao WD, Zhang SC, Dong MNature communicationsCytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival. Nat Commun. 2013; 4:1472.Nat Commun2013-01-01T00:00:002013Cytotoxicity of botulinum neurotoxins reveals a direct role of syntaxin 1 and SNAP-25 in neuron survival.22454523Peng L, Berntsson RP, Tepp WH, Pitkin RM, Johnson EA, Stenmark P, Dong MJournal of cell scienceBotulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins. J Cell Sci. 2012 Jul 01; 125(Pt 13):3233-42.J Cell Sci2012-03-27T00:00:002012Botulinum neurotoxin D-C uses synaptotagmin I and II as receptors, and human synaptotagmin II is not an effective receptor for type B, D-C and G toxins.XX57XiaozheXiongXiaozhe Xiong, Ph.D.174671Xiong, XiaozheResearch Fellow in SurgeryAuthorship 1109821130388027Dong M, Masuyer G, Stenmark PAnnual review of biochemistryBotulinum and Tetanus Neurotoxins. Annu Rev Biochem. 2019 06 20; 88:811-837.Annu Rev Biochem2018-11-02T00:00:002018Botulinum and Tetanus Neurotoxins.Authorship 11166131230481169Tian S, Muneeruddin K, Choi MY, Tao L, Bhuiyan RH, Ohmi Y, Furukawa K, Furukawa K, Boland S, Shaffer SA, Adam RM, Dong MPLoS biologyGenome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation. PLoS Biol. 2018 11; 16(11):e2006951.PLoS Biol2018-11-27T00:00:002018Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation.2020-11-30DONG, MIN2018-12-07Novel anti-cancer biologics targeting Wnt signaling pathwayR21CA235533Principal Investigatorhttp://donglab.hms.harvard.eduLab websiteD037521Chemicals & Drugs2245070.733707Virulence FactorsD001427Chemicals & Drugs2969380.632845Bacterial ToxinsD050861Chemicals & Drugs12150.980712Synaptotagmin IID019274Chemicals & Drugs1212040.770824Botulinum Toxins, Type AD001905Chemicals & Drugs1131910.838719Botulinum ToxinsBiostatisticsEmeritusGeneticsMedicinePathologyPediatricsPsychiatrySurgeryGastroenterologyUrologyEndocrinologyInfectious DiseaseBeth Israel Deaconess Medical CenterBoston Children's HospitalHarvard Medical SchoolHarvard T.H. Chan School of Public HealthMcLean HospitalDTB1DavidBreaultDavid T. Breault, M.D., Ph.D.42.33813400000000-71.1057260000000087359Breault, DavidAssociate Professor of PediatricsJTL2JohnLamontJohn T. Lamont, M.D.42.34022770000000-71.1058540000000074833Lamont, JohnCharlotte F. and Irving W. Rabb Distinguished Professor of MedicineCPK1CiaranKellyCiaran Patrick Kelly, M.B., M.D.42.34022770000000-71.105854000000005983Kelly, CiaranProfessor of MedicineAK189AndreaKirmaierAndrea Kirmaier, Ph.D.42.32602700000000-71.5001820000000013187Kirmaier, AndreaResearch Fellow in PathologyWHM1WilliamMorseWilliam Herbert Morse, Ph.D.42.32602700000000-71.5001820000000046587Morse, WilliamProfessor of Psychiatry, Emeritus1136selected publications4.900540.00983874221research areas1.652960.039672534coauthor of66.59177.7342760similar toJMB17JamesBillingsleyJames Michael Billingsley42.32602700000000-71.5001820000000078921Billingsley, JamesResearch ScientistAuthorship 11583631131160825Tao L, Tian S, Zhang J, Liu Z, Robinson-McCarthy L, Miyashita SI, Breault DT, Gerhard R, Oottamasathien S, Whelan SPJ, Dong MNature microbiologySulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells. Nat Microbiol. 2019 10; 4(10):1760-1769.Nat Microbiol2019-06-03T00:00:002019Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells.RJC8R. JohnCollierR. John Collier, Ph.D.42.33594500000000-71.1029580000000044225Collier, R. JohnMaude and Lillian Presley Professor of Microbiology and Immunobiology, EmeritusNP11NiraPollockNira Pollock, M.D., Ph.D.42.33700000000000-71.1100000000000031182Pollock, NiraAssociate Professor of PathologyBKM2BerthaMadrasBertha Kalifon Madras, Ph.D.42.32602700000000-71.500182000000002567Madras, BerthaProfessor of Psychobiology in the Department of PsychiatryMRF3MichaelFarzanMichael Reynolds Farzan, Ph.D.42.32602700000000-71.5001820000000054132Farzan, MichaelProfessor of PediatricsNP7NorbertPerrimonNorbert Perrimon, Ph.D.42.33837200000000-71.103269000000006247Perrimon, NorbertJames Stillman Professor of Developmental BiologyHT145HatimThakerHatim Thaker, M.D.181144Thaker, HatimInstructor in SurgeryAuthorship 1356307Authorship 1186965731484065Tian S, Wu Q, Zhou B, Choi MY, Ding B, Yang W, Dong MCell reportsProteomic Analysis Identifies Membrane Proteins Dependent on the ER Membrane Protein Complex. Cell Rep. 2019 09 03; 28(10):2517-2526.e5.Cell Rep2019-09-03T00:00:002019Proteomic Analysis Identifies Membrane Proteins Dependent on the ER Membrane Protein Complex.true1Professor of Psychobiology in the Department of PsychiatryProfessor of Psychobiology in the Department of Psychiatrytrue1Maude and Lillian Presley Professor of Microbiology and Immunobiology, EmeritusMaude and Lillian Presley Professor of Microbiology and Immunobiology, Emeritustrue1Professor of MedicineProfessor of Medicinetrue1James Stillman Professor of Developmental BiologyJames Stillman Professor of Developmental Biologytrue1Charlotte F. and Irving W. Rabb Distinguished Professor of MedicineCharlotte F. and Irving W. Rabb Distinguished Professor of MedicineAuthorship 1207096131792680Dong M, Stenmark PHandbook of experimental pharmacologyThe Structure and Classification of Botulinum Toxins. Handb Exp Pharmacol. 2021; 263:11-33.Handb Exp Pharmacol2021-01-01T00:00:002021The Structure and Classification of Botulinum Toxins.Authorship 1216890931924910Shen Y, Wu SY, Rancic V, Aggarwal A, Qian Y, Miyashita SI, Ballanyi K, Campbell RE, Dong MCommunications biologyGenetically encoded fluorescent indicators for imaging intracellular potassium ion concentration. Commun Biol. 2019 Jan 14; 2(1):18.Commun Biol2019-01-14T00:00:002019Genetically encoded fluorescent indicators for imaging intracellular potassium ion concentration.JM577JohnManionJohn Manion, Ph.D.187764Manion, JohnResearch Fellow in SurgeryAuthorship 12336471132182233Yin L, Masuyer G, Zhang S, Zhang J, Miyashita SI, Burgin D, Lovelock L, Coker SF, Fu TM, Stenmark P, Dong MPLoS biologyCharacterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy. PLoS Biol. 2020 03; 18(3):e3000618.PLoS Biol2020-03-17T00:00:002020Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy.Principal InvestigatorAuthorship 123636617Authorship 12363675Authorship 123636810Authorship 12363694Authorship 123637010Authorship 123637182023-04-30DONG, MIN2013-03-01Biology and Engineering of Botulinum Neurotoxins.2R01NS080833-0729748286Chen P, Tao L, Wang T, Zhang J, He A, Lam KH, Liu Z, He X, Perry K, Dong M, Jin RScience (New York, N.Y.)Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B. Science. 2018 05 11; 360(6389):664-669.Science2018-05-11T00:00:002018Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B.30733520Mansfield MJ, Wentz TG, Zhang S, Lee EJ, Dong M, Sharma SK, Doxey ACScientific reportsBioinformatic discovery of a toxin family in Chryseobacterium piperi with sequence similarity to botulinum neurotoxins. Sci Rep. 2019 02 07; 9(1):1634.Sci Rep2019-02-07T00:00:002019Bioinformatic discovery of a toxin family in Chryseobacterium piperi with sequence similarity to botulinum neurotoxins.29649119Gustafsson R, Zhang S, Masuyer G, Dong M, Stenmark PToxinsCrystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding. Toxins (Basel). 2018 04 12; 10(4).Toxins (Basel)2018-04-12T00:00:002018Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding.27294781Yao G, Zhang S, Mahrhold S, Lam KH, Stern D, Bagramyan K, Perry K, Kalkum M, Rummel A, Dong M, Jin RNature structural & molecular biologyN-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. Nat Struct Mol Biol. 2016 07; 23(7):656-62.Nat Struct Mol Biol2016-06-13T00:00:002016N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.24948737Lee K, Zhong X, Gu S, Kruel AM, Dorner MB, Perry K, Rummel A, Dong M, Jin RScience (New York, N.Y.)Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex. Science. 2014 Jun 20; 344(6190):1405-10.Science2014-06-20T00:00:002014Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex.30746458Elliott M, Favre-Guilmard C, Liu SM, Maignel J, Masuyer G, Beard M, Boone C, Carré D, Kalinichev M, Lezmi S, Mir I, Nicoleau C, Palan S, Perier C, Raban E, Zhang S, Dong M, Stenmark P, Krupp JScience advancesEngineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models. Sci Adv. 2019 01; 5(1):eaau7196.Sci Adv2019-01-16T00:00:002019Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.32302524Tian S, Liu Y, Wu H, Liu H, Zeng J, Choi MY, Chen H, Gerhard R, Dong MCell host & microbeGenome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B as Receptors for Paeniclostridium sordellii Toxin TcsL. Cell Host Microbe. 2020 05 13; 27(5):782-792.e7.Cell Host Microbe2020-04-16T00:00:002020Genome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B as Receptors for Paeniclostridium sordellii Toxin TcsL.Authorship 12403619Authorship 13068381133201535Soul JS, Bergin AM, Stopp C, Hayes B, Singh A, Fortuno CR, O'Reilly D, Krishnamoorthy K, Jensen FE, Rofeberg V, Dong M, Vinks AA, Wypij D, Staley KJAnnals of neurologyA Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. Ann Neurol. 2021 02; 89(2):327-340.Ann Neurol2020-12-03T00:00:002020A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures.Authorship 13162905Authorship 1316227433394765Thaker H, Zhang S, Diamond DA, Dong MCurrent opinion in urologyBeyond botulinum neurotoxin A for chemodenervation of the bladder. Curr Opin Urol. 2021 03 01; 31(2):140-146.Curr Opin Urol2021-03-01T00:00:002021Beyond botulinum neurotoxin A for chemodenervation of the bladder.33408184Miyashita SI, Zhang J, Zhang S, Shoemaker CB, Dong MScience translational medicineDelivery of single-domain antibodies into neurons using a chimeric toxin-based platform is therapeutic in mouse models of botulism. Sci Transl Med. 2021 01 06; 13(575).Sci Transl Med2021-01-06T00:00:002021Delivery of single-domain antibodies into neurons using a chimeric toxin-based platform is therapeutic in mouse models of botulism.Authorship 13248852833531666Shao DD, Straussberg R, Ahmed H, Khan A, Tian S, Hill RS, Smith RS, Majmundar AJ, Ameziane N, Neil JE, Yang E, Al Tenaiji A, Jamuar SS, Schlaeger TM, Al-Saffar M, Hovel I, Al-Shamsi A, Basel-Salmon L, Amir AZ, Rento LM, Lim JY, Ganesan I, Shril S, Evrony G, Barkovich AJ, Bauer P, Hildebrandt F, Dong M, Borck G, Beetz C, Al-Gazali L, Eyaid W, Walsh CAGenetics in medicine : official journal of the American College of Medical GeneticsA recurrent, homozygous EMC10 frameshift variant is associated with a syndrome of developmental delay with variable seizures and dysmorphic features. Genet Med. 2021 06; 23(6):1158-1162.Genet Med2021-02-02T00:00:002021A recurrent, homozygous EMC10 frameshift variant is associated with a syndrome of developmental delay with variable seizures and dysmorphic features.Authorship 13320551033602850Blum TR, Liu H, Packer MS, Xiong X, Lee PG, Zhang S, Richter M, Minasov G, Satchell KJF, Dong M, Liu DRScience (New York, N.Y.)Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity. Science. 2021 02 19; 371(6531):803-810.Science2021-02-19T00:00:002021Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity.34662366Thaker H, Zhang J, Miyashita SI, Cristofaro V, Park S, Hashemi Gheinani A, Sullivan MP, Adam RM, Dong MPLoS pathogensKnockin mouse models demonstrate differential contributions of synaptotagmin-1 and -2 as receptors for botulinum neurotoxins. PLoS Pathog. 2021 10; 17(10):e1009994.PLoS Pathog2021-10-18T00:00:002021Knockin mouse models demonstrate differential contributions of synaptotagmin-1 and -2 as receptors for botulinum neurotoxins.Authorship 14046119Authorship 143665519Authorship 1439004635259335Xiong X, Tian S, Yang P, Lebreton F, Bao H, Sheng K, Yin L, Chen P, Zhang J, Qi W, Ruan J, Wu H, Chen H, Breault DT, Wu H, Earl AM, Gilmore MS, Abraham J, Dong MCellEmerging enterococcus pore-forming toxins with MHC/HLA-I as receptors. Cell. 2022 03 31; 185(7):1157-1171.e22.Cell2022-03-07T00:00:002022Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors.35263584Tian S, Liu Y, Appleton E, Wang H, Church GM, Dong MCell reportsTargeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms. Cell Rep. 2022 Mar 08; 38(10):110476.Cell Rep2022-03-08T00:00:002022Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms.Authorship 149355321Authorship 150026511Authorship 15011921836351897Tian S, Xiong X, Zeng J, Wang S, Tremblay BJ, Chen P, Chen B, Liu M, Chen P, Sheng K, Zeve D, Qi W, Breault DT, Rodríguez C, Gerhard R, Jin R, Doxey AC, Dong MNature communicationsIdentification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants. Nat Commun. 2022 11 09; 13(1):6786.Nat Commun2022-11-09T00:00:002022Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants.36171290Xu Y, Viswanatha R, Sitsel O, Roderer D, Zhao H, Ashwood C, Voelcker C, Tian S, Raunser S, Perrimon N, Dong MNatureCRISPR screens in Drosophila cells identify Vsg as a Tc toxin receptor. Nature. 2022 10; 610(7931):349-355.Nature2022-09-28T00:00:002022CRISPR screens in Drosophila cells identify Vsg as a Tc toxin receptor.36270774He A, Ma L, Huang Y, Zhang H, Duan W, Li Z, Fei T, Yuan J, Wu H, Liu L, Bai Y, Dai W, Wang Y, Li H, Sun Y, Wang Y, Wang C, Yuan T, Yang Q, Tian S, Dong M, Sheng R, Xiang DLife science allianceCorrection: CDKL3 promotes osteosarcoma progression by activating Akt/PKB. Life Sci Alliance. 2022 Nov; 5(11).Life Sci Alliance2022-10-21T00:00:002022Correction: CDKL3 promotes osteosarcoma progression by activating Akt/PKB.37699522Manion J, Musser MA, Kuziel GA, Liu M, Shepherd A, Wang S, Lee PG, Zhao L, Zhang J, Marreddy RKR, Goldsmith JD, Yuan K, Hurdle JG, Gerhard R, Jin R, Rakoff-Nahoum S, Rao M, Dong MNatureC. difficile intoxicates neurons and pericytes to drive neurogenic inflammation. Nature. 2023 Oct; 622(7983):611-618.Nature2023-09-12T00:00:002023C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation.Authorship 158766918true1Professor of Psychiatry, EmeritusProfessor of Psychiatry, Emeritustrue1Research Fellow in PathologyResearch Fellow in Pathologytrue1Associate Professor of PathologyAssociate Professor of Pathologytrue1Professor of PediatricsProfessor of Pediatricstrue1Research ScientistResearch Scientisttrue1Research Fellow in SurgeryResearch Fellow in Surgerytrue1Research Fellow in SurgeryResearch Fellow in Surgerytrue1Associate Professor of SurgeryAssociate Professor of Surgerytrue1Instructor in SurgeryInstructor in Surgerytrue1Research Fellow in SurgeryResearch Fellow in Surgerytrue1Associate Professor of PediatricsAssociate Professor of PediatricsAuthorship 7422011125010769Peng L, Adler M, Demogines A, Borrell A, Liu H, Tao L, Tepp WH, Zhang SC, Johnson EA, Sawyer SL, Dong MPLoS pathogensWidespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins. PLoS Pathog. 2014 Jul; 10(7):e1004177.PLoS Pathog2014-07-10T00:00:002014Widespread sequence variations in VAMP1 across vertebrates suggest a potential selective pressure from botulinum neurotoxins.Authorship 480604Authorship 334626101Associate Professor6Fellow or Post Doc0Full Professor4Instructor5Other Faculty2013-04-30FLIER, JEFFREY S1978-06-01New England Primate Research Center Base GrantP51RR0001682015-08-31DONG, MIN2015-05-01Next generation of botulinum neurotoxins with enhanced binding to human receptorsR21NS0828302018-02-28DONG, MIN2013-03-01Biology and Engineering of Botulinum Neurotoxins.R01NS0808332014-08-19DONG, MIN2012-08-20Cytotoxicity of botulinum neurotoxinsR56AI097834Principal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal Investigator27680706Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong MNatureFrizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature. 2016 Oct 20; 538(7625):350-355.Nature2016-09-28T00:00:002016Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.Authorship 9402001421483489Peng L, Tepp WH, Johnson EA, Dong MPLoS pathogensBotulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors. PLoS Pathog. 2011 Mar; 7(3):e1002008.PLoS Pathog2011-03-31T00:00:002011Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors.Authorship 9979051328674381Tao L, Peng L, Berntsson RP, Liu SM, Park S, Yu F, Boone C, Palan S, Beard M, Chabrier PE, Stenmark P, Krupp J, Dong MNature communicationsEngineered botulinum neurotoxin B with improved efficacy for targeting human receptors. Nat Commun. 2017 07 03; 8(1):53.Nat Commun2017-07-03T00:00:002017Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors.Authorship 1004808928770820Zhang S, Masuyer G, Zhang J, Shen Y, Lundin D, Henriksson L, Miyashita SI, Martínez-Carranza M, Dong M, Stenmark PNature communicationsIdentification and characterization of a novel botulinum neurotoxin. Nat Commun. 2017 08 03; 8:14130.Nat Commun2017-08-03T00:00:002017Identification and characterization of a novel botulinum neurotoxin.2022-05-31DONG, MIN2017-06-01Molecular basis of action and pathogenesis of Clostridium difficile toxin BR01AI132387Principal InvestigatorAuthorship 1028750729158482Zhang S, Berntsson RP, Tepp WH, Tao L, Johnson EA, Stenmark P, Dong MNature communicationsStructural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC. Nat Commun. 2017 11 21; 8(1):1637.Nat Commun2017-11-21T00:00:002017Structural basis for the unique ganglioside and cell membrane recognition mechanism of botulinum neurotoxin DC.Authorship 1036164728871080Huang NJ, Pishesha N, Mukherjee J, Zhang S, Deshycka R, Sudaryo V, Dong M, Shoemaker CB, Lodish HFNature communicationsGenetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin. Nat Commun. 2017 09 04; 8(1):423.Nat Commun2017-09-04T00:00:002017Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin.300 Longwood AveChildren's HospitalDept. of Urology, En 1070300 Longwood AveBoston02115MA