ANE1AlanEngelmanAlan N. Engelman, Ph.D.42.33789600000000-71.1072493000000077713Engelman, AlanN.617/632-4361Professor of Medicinecatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson10384245Engelman AAdvances in virus researchIn vivo analysis of retroviral integrase structure and function. Adv Virus Res. 1999; 52:411-26.Adv Virus Res1999-01-01T00:00:001999In vivo analysis of retroviral integrase structure and function.Authorship 1048999129417178Engelman AN, Singh PKCellular and molecular life sciences : CMLSCellular and molecular mechanisms of HIV-1 integration targeting. Cell Mol Life Sci. 2018 Jul; 75(14):2491-2507.Cell Mol Life Sci2018-02-07T00:00:002018Cellular and molecular mechanisms of HIV-1 integration targeting.Authorship 102137320227665Lee K, Ambrose Z, Martin TD, Oztop I, Mulky A, Julias JG, Vandegraaff N, Baumann JG, Wang R, Yuen W, Takemura T, Shelton K, Taniuchi I, Li Y, Sodroski J, Littman DR, Coffin JM, Hughes SH, Unutmaz D, Engelman A, KewalRamani VNCell host & microbeFlexible use of nuclear import pathways by HIV-1. Cell Host Microbe. 2010 Mar 18; 7(3):221-33.Cell Host Microbe2010-03-18T00:00:002010Flexible use of nuclear import pathways by HIV-1.19266025Yan N, Cherepanov P, Daigle JE, Engelman A, Lieberman JPLoS pathogensThe SET complex acts as a barrier to autointegration of HIV-1. PLoS Pathog. 2009 Mar; 5(3):e1000327.PLoS Pathog2009-03-06T00:00:002009The SET complex acts as a barrier to autointegration of HIV-1.20133638Ferris AL, Wu X, Hughes CM, Stewart C, Smith SJ, Milne TA, Wang GG, Shun MC, Allis CD, Engelman A, Hughes SHProceedings of the National Academy of Sciences of the United States of AmericaLens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3135-40.Proc Natl Acad Sci U S A2010-02-01T00:00:002010Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.19864417Hughes S, Jenkins V, Dar MJ, Engelman A, Cherepanov PThe Journal of biological chemistryTranscriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity. J Biol Chem. 2010 Jan 01; 285(1):541-54.J Biol Chem2009-10-28T00:00:002009Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity.19490971Belshan M, Schweitzer CJ, Donnellan MR, Lu R, Engelman AJournal of virological methodsIn vivo biotinylation and capture of HIV-1 matrix and integrase proteins. J Virol Methods. 2009 Aug; 159(2):178-84.J Virol Methods2009-03-26T00:00:002009In vivo biotinylation and capture of HIV-1 matrix and integrase proteins.21576478Yan N, O'Day E, Wheeler LA, Engelman A, Lieberman JProceedings of the National Academy of Sciences of the United States of AmericaHIV DNA is heavily uracilated, which protects it from autointegration. Proc Natl Acad Sci U S A. 2011 May 31; 108(22):9244-9.Proc Natl Acad Sci U S A2011-05-16T00:00:002011HIV DNA is heavily uracilated, which protects it from autointegration.22278243Li X, Koh Y, Engelman AJournal of virologyCorrelation of recombinant integrase activity and functional preintegration complex formation during acute infection by replication-defective integrase mutant human immunodeficiency virus. J Virol. 2012 Apr; 86(7):3861-79.J Virol2012-01-25T00:00:002012Correlation of recombinant integrase activity and functional preintegration complex formation during acute infection by replication-defective integrase mutant human immunodeficiency virus.14694097Lu R, Nakajima N, Hofmann W, Benkirane M, Jeang KT, Sodroski J, Engelman A, Teh-Jeang KJournal of virologySimian virus 40-based replication of catalytically inactive human immunodeficiency virus type 1 integrase mutants in nonpermissive T cells and monocyte-derived macrophages. J Virol. 2004 Jan; 78(2):658-68.J Virol2004-01-01T00:00:002004Simian virus 40-based replication of catalytically inactive human immunodeficiency virus type 1 integrase mutants in nonpermissive T cells and monocyte-derived macrophages.16260736Cherepanov P, Ambrosio AL, Rahman S, Ellenberger T, Engelman AProceedings of the National Academy of Sciences of the United States of AmericaStructural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75. Proc Natl Acad Sci U S A. 2005 Nov 29; 102(48):17308-13.Proc Natl Acad Sci U S A2005-10-31T00:00:002005Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.16973579Anderson JL, Campbell EM, Wu X, Vandegraaff N, Engelman A, Hope TJJournal of virologyProteasome inhibition reveals that a functional preintegration complex intermediate can be generated during restriction by diverse TRIM5 proteins. J Virol. 2006 Oct; 80(19):9754-60.J Virol2006-10-01T00:00:002006Proteasome inhibition reveals that a functional preintegration complex intermediate can be generated during restriction by diverse TRIM5 proteins.Authorship 10601477535863Engelman A, Englund G, Orenstein JM, Martin MA, Craigie RJournal of virologyMultiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication. J Virol. 1995 May; 69(5):2729-36.J Virol1995-05-01T00:00:001995Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.23097435Shah VB, Shi J, Hout DR, Oztop I, Krishnan L, Ahn J, Shotwell MS, Engelman A, Aiken CJournal of virologyThe host proteins transportin SR2/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating. J Virol. 2013 Jan; 87(1):422-32.J Virol2012-10-24T00:00:002012The host proteins transportin SR2/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating.15677323Engelman AProceedings of the National Academy of Sciences of the United States of AmericaThe ups and downs of gene expression and retroviral DNA integration. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1275-6.Proc Natl Acad Sci U S A2005-01-26T00:00:002005The ups and downs of gene expression and retroviral DNA integration.2164639Engelman A, Rosenberg NMolecular and cellular biologybcr/abl and src but not myc and ras replace v-abl in lymphoid transformation. Mol Cell Biol. 1990 Aug; 10(8):4365-9.Mol Cell Biol1990-08-01T00:00:001990bcr/abl and src but not myc and ras replace v-abl in lymphoid transformation.19020823Engelman AMethods in molecular biology (Clifton, N.J.)Isolation and analysis of HIV-1 preintegration complexes. Methods Mol Biol. 2009; 485:135-49.Methods Mol Biol2009-01-01T00:00:002009Isolation and analysis of HIV-1 preintegration complexes.21454548Zamborlini A, Coiffic A, Beauclair G, Delelis O, Paris J, Koh Y, Magne F, Giron ML, Tobaly-Tapiero J, Deprez E, Emiliani S, Engelman A, de Thé H, Saïb AThe Journal of biological chemistryImpairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect. J Biol Chem. 2011 Jun 10; 286(23):21013-22.J Biol Chem2011-03-21T00:00:002011Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect.16735438Maertens GN, Cherepanov P, Engelman AJournal of cell scienceTranscriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin. J Cell Sci. 2006 Jun 15; 119(Pt 12):2563-71.J Cell Sci2006-05-30T00:00:002006Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin.18432923Byers KB, Engelman A, Fontes BCurrent protocols in immunologyGeneral guidelines for experimenting with HIV. Curr Protoc Immunol. 2004 May; Chapter 12:Unit 12.1.Curr Protoc Immunol2004-05-01T00:00:002004General guidelines for experimenting with HIV.18799576Shun MC, Botbol Y, Li X, Di Nunzio F, Daigle JE, Yan N, Lieberman J, Lavigne M, Engelman AJournal of virologyIdentification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity. J Virol. 2008 Dec; 82(23):11555-67.J Virol2008-09-17T00:00:002008Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity.19840380Dar MJ, Monel B, Krishnan L, Shun MC, Di Nunzio F, Helland DE, Engelman ARetrovirologyBiochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase. Retrovirology. 2009 Oct 19; 6:94.Retrovirology2009-10-19T00:00:002009Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase.21270168Koh Y, Matreyek KA, Engelman AJournal of virologyDifferential sensitivities of retroviruses to integrase strand transfer inhibitors. J Virol. 2011 Apr; 85(7):3677-82.J Virol2011-01-26T00:00:002011Differential sensitivities of retroviruses to integrase strand transfer inhibitors.Authorship 10917281430173955Achuthan V, Perreira JM, Sowd GA, Puray-Chavez M, McDougall WM, Paulucci-Holthauzen A, Wu X, Fadel HJ, Poeschla EM, Multani AS, Hughes SH, Sarafianos SG, Brass AL, Engelman ANCell host & microbeCapsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration. Cell Host Microbe. 2018 09 12; 24(3):392-404.e8.Cell Host Microbe2018-08-30T00:00:002018Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration.8057470Engelman A, Hickman AB, Craigie RJournal of virologyThe core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding. J Virol. 1994 Sep; 68(9):5911-7.J Virol1994-09-01T00:00:001994The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding.8344264Engelman A, Bushman FD, Craigie RThe EMBO journalIdentification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex. EMBO J. 1993 Aug; 12(8):3269-75.EMBO J1993-08-01T00:00:001993Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex.21593146Matreyek KA, Engelman AJournal of virologyThe requirement for nucleoporin NUP153 during human immunodeficiency virus type 1 infection is determined by the viral capsid. J Virol. 2011 Aug; 85(15):7818-27.J Virol2011-05-18T00:00:002011The requirement for nucleoporin NUP153 during human immunodeficiency virus type 1 infection is determined by the viral capsid.22437836Kessl JJ, Jena N, Koh Y, Taskent-Sezgin H, Slaughter A, Feng L, de Silva S, Wu L, Le Grice SF, Engelman A, Fuchs JR, Kvaratskhelia MThe Journal of biological chemistryMultimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors. J Biol Chem. 2012 May 11; 287(20):16801-11.J Biol Chem2012-03-21T00:00:002012Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors.18369482Engelman A, Cherepanov PPLoS pathogensThe lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication. PLoS Pathog. 2008 Mar 28; 4(3):e1000046.PLoS Pathog2008-03-28T00:00:002008The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.23030323Matreyek KA, Oztop I, Freed EO, Engelman AExpert review of anti-infective therapyViral latency and potential eradication of HIV-1. Expert Rev Anti Infect Ther. 2012 Aug; 10(8):855-7.Expert Rev Anti Infect Ther2012-08-01T00:00:002012Viral latency and potential eradication of HIV-1.23043109Krishnan L, Engelman AThe Journal of biological chemistryRetroviral integrase proteins and HIV-1 DNA integration. J Biol Chem. 2012 Nov 30; 287(49):40858-66.J Biol Chem2012-10-05T00:00:002012Retroviral integrase proteins and HIV-1 DNA integration.16160186Lu R, Vandegraaff N, Cherepanov P, Engelman AJournal of virologyLys-34, dispensable for integrase catalysis, is required for preintegration complex function and human immunodeficiency virus type 1 replication. J Virol. 2005 Oct; 79(19):12584-91.J Virol2005-10-01T00:00:002005Lys-34, dispensable for integrase catalysis, is required for preintegration complex function and human immunodeficiency virus type 1 replication.7840756Engelman ABioEssays : news and reviews in molecular, cellular and developmental biologyMost of the avian genome appears available for retroviral DNA integration. Bioessays. 1994 Nov; 16(11):797-9.Bioessays1994-11-01T00:00:001994Most of the avian genome appears available for retroviral DNA integration.16648259Si Z, Vandegraaff N, O'huigin C, Song B, Yuan W, Xu C, Perron M, Li X, Marasco WA, Engelman A, Dean M, Sodroski JProceedings of the National Academy of Sciences of the United States of AmericaEvolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection. Proc Natl Acad Sci U S A. 2006 May 09; 103(19):7454-9.Proc Natl Acad Sci U S A2006-04-28T00:00:002006Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection.8386373Bushman FD, Engelman A, Palmer I, Wingfield P, Craigie RProceedings of the National Academy of Sciences of the United States of AmericaDomains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3428-32.Proc Natl Acad Sci U S A1993-04-15T00:00:001993Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding.7632683Lodi PJ, Ernst JA, Kuszewski J, Hickman AB, Engelman A, Craigie R, Clore GM, Gronenborn AMBiochemistrySolution structure of the DNA binding domain of HIV-1 integrase. Biochemistry. 1995 Aug 08; 34(31):9826-33.Biochemistry1995-08-08T00:00:001995Solution structure of the DNA binding domain of HIV-1 integrase.10358097Chen H, Wei SQ, Engelman AThe Journal of biological chemistryMultiple integrase functions are required to form the native structure of the human immunodeficiency virus type I intasome. J Biol Chem. 1999 Jun 11; 274(24):17358-64.J Biol Chem1999-06-11T00:00:001999Multiple integrase functions are required to form the native structure of the human immunodeficiency virus type I intasome.Microbiology7961898Hickman AB, Palmer I, Engelman A, Craigie R, Wingfield PThe Journal of biological chemistryBiophysical and enzymatic properties of the catalytic domain of HIV-1 integrase. J Biol Chem. 1994 Nov 18; 269(46):29279-87.J Biol Chem1994-11-18T00:00:001994Biophysical and enzymatic properties of the catalytic domain of HIV-1 integrase.12368302Limón A, Devroe E, Lu R, Ghory HZ, Silver PA, Engelman AJournal of virologyNuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import. J Virol. 2002 Nov; 76(21):10598-607.J Virol2002-11-01T00:00:002002Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import.1696637Engelman A, Rosenberg NJournal of virologyTemperature-sensitive mutants of Abelson murine leukemia virus deficient in protein tyrosine kinase activity. J Virol. 1990 Sep; 64(9):4242-51.J Virol1990-09-01T00:00:001990Temperature-sensitive mutants of Abelson murine leukemia virus deficient in protein tyrosine kinase activity.7801124Dyda F, Hickman AB, Jenkins TM, Engelman A, Craigie R, Davies DRScience (New York, N.Y.)Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases. Science. 1994 Dec 23; 266(5193):1981-6.Science1994-12-23T00:00:001994Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases.16549878Turlure F, Maertens G, Rahman S, Cherepanov P, Engelman ANucleic acids researchA tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo. Nucleic Acids Res. 2006; 34(5):1653-65.Nucleic Acids Res2006-03-20T00:00:002006A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo.16959283Rahman S, Lu R, Vandegraaff N, Cherepanov P, Engelman AVirologyStructure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness. Virology. 2007 Jan 05; 357(1):79-90.Virology2006-09-07T00:00:002006Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness.D015497Living Beings83469310.277707HIV-1Authorship 1207315Authorship 1142167830916345Jang S, Cook NJ, Pye VE, Bedwell GJ, Dudek AM, Singh PK, Cherepanov P, Engelman ANNucleic acids researchDifferential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6. Nucleic Acids Res. 2019 05 21; 47(9):4663-4683.Nucleic Acids Res2019-05-21T00:00:002019Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6.D019426Chemicals & Drugs3085320.796708IntegrasesD019427Chemicals & Drugs401200.882925HIV IntegraseD019428Chemicals & Drugs701440.834331HIV Integrase InhibitorsD016662Phenomena1162970.833418Virus IntegrationMedicineViral PathogenesisInfectious DiseaseOncologyVaccine ResearchBeth Israel Deaconess Medical CenterBrigham and Women's HospitalDana-Farber Cancer InstituteMassachusetts General HospitalADC8AtishChoudhuryAtish Dipankar Choudhury, M.D., Ph.D.42.33789600000000-71.1072493000000058523Choudhury, AtishAssistant Professor of MedicineND2NikaDanialNika Danial, Ph.D.42.33789600000000-71.107249300000007472Danial, NikaAssociate Professor of MedicineAuthorship 11564161031120420Koneru PC, Francis AC, Deng N, Rebensburg SV, Hoyte AC, Lindenberger J, Adu-Ampratwum D, Larue RC, Wempe MF, Engelman AN, Lyumkis D, Fuchs JR, Levy RM, Melikyan GB, Kvaratskhelia MeLifeHIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors. Elife. 2019 05 23; 8.Elife2019-05-23T00:00:002019HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.11203selected publications17.05640.00430937497research areas3.593880.018059548coauthor of278.92729.470560similar toBDW1BruceWalkerBruce David Walker, M.D.42.37730000000000-71.0525000000000079342Walker, BrucePhillip T. and Susan M. Ragon Professor of MedicineKGS2KristenSchaeferKristen Gallion Schaefer, M.D.42.33789600000000-71.1072493000000029862Schaefer, KristenAssistant Professor of Medicine, Part-timeDHB3DanBarouchDan Hung Barouch, M.D.42.34022770000000-71.1058540000000028268Barouch, DanWilliam Bosworth Castle Professor of MedicineJZL2JonathanLiJonathan Zheng Li, M.D.42.36070000000000-71.1009000000000058291Li, JonathanAssociate Professor of MedicineML79MathiasLichterfeldMathias Lichterfeld, M.D., Ph.D.42.37730000000000-71.0525000000000043487Lichterfeld, MathiasProfessor of MedicineJK3JohnKorethJohn Koreth, M.B.,B.S.42.33789600000000-71.1072493000000061027Koreth, JohnProfessor of MedicinePH18PingHuaPing Hua, M.D.42.33789600000000-71.1072493000000069252Hua, PingResearch Associate in MedicineJGS10JosephSodroskiJoseph Gerard Sodroski, M.D.42.33789600000000-71.1072493000000042351Sodroski, JosephProfessor of MicrobiologyCo-Principal InvestigatorDRK3DanielKuritzkesDaniel Robert Kuritzkes, M.D.42.36070000000000-71.1009000000000062664Kuritzkes, DanielHarriet Ryan Albee Professor of MedicineAuthorship 1166439731254557Zhang DW, Luo RH, Xu L, Yang LM, Xu XS, Bedwell GJ, Engelman AN, Zheng YT, Chang SAntiviral researchA HTRF based competitive binding assay for screening specific inhibitors of HIV-1 capsid assembly targeting the C-Terminal domain of capsid. Antiviral Res. 2019 09; 169:104544.Antiviral Res2019-06-27T00:00:002019A HTRF based competitive binding assay for screening specific inhibitors of HIV-1 capsid assembly targeting the C-Terminal domain of capsid.Authorship 11855785Authorship 11829771Authorship 1185781531467082Engelman ANThe Journal of biological chemistryMultifaceted HIV integrase functionalities and therapeutic strategies for their inhibition. J Biol Chem. 2019 10 11; 294(41):15137-15157.J Biol Chem2019-08-29T00:00:002019Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition.31413124Anderson-Daniels J, Singh PK, Sowd GA, Li W, Engelman AN, Aiken CJournal of virologyDominant Negative MA-CA Fusion Protein Is Incorporated into HIV-1 Cores and Inhibits Nuclear Entry of Viral Preintegration Complexes. J Virol. 2019 11 01; 93(21).J Virol2019-10-15T00:00:002019Dominant Negative MA-CA Fusion Protein Is Incorporated into HIV-1 Cores and Inhibits Nuclear Entry of Viral Preintegration Complexes.31448372Achuthan V, Perreira JM, Ahn JJ, Brass AL, Engelman ANJournal of life sciences (Westlake Village, Calif.)Capsid-CPSF6 interaction: Master regulator of nuclear HIV-1 positioning and integration. J Life Sci (Westlake Village). 2019 Jun; 1(1):39-45.J Life Sci (Westlake Village)2019-06-01T00:00:002019Capsid-CPSF6 interaction: Master regulator of nuclear HIV-1 positioning and integration.Authorship 1153392Authorship 1451813true1Research Associate in MedicineResearch Associate in Medicinetrue1Professor of MicrobiologyProfessor of Microbiologytrue1Professor of MedicineProfessor of Medicinetrue1Harriet Ryan Albee Professor of MedicineHarriet Ryan Albee Professor of Medicinetrue1Research Associate in MedicineResearch Associate in MedicineAuthorship 1244562Authorship 12114381431815961Loyola L, Achuthan V, Gilroy K, Borland G, Kilbey A, Mackay N, Bell M, Hay J, Aiyer S, Fingerman D, Villanueva RA, Cameron E, Kozak CA, Engelman AN, Neil J, Roth MJPLoS pathogensDisrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model. PLoS Pathog. 2019 12; 15(12):e1008154.PLoS Pathog2019-12-09T00:00:002019Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model.Authorship 1221260932001525Cook NJ, Li W, Berta D, Badaoui M, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov PScience (New York, N.Y.)Structural basis of second-generation HIV integrase inhibitor action and viral resistance. Science. 2020 02 14; 367(6479):806-810.Science2020-01-30T00:00:002020Structural basis of second-generation HIV integrase inhibitor action and viral resistance.Authorship 1227762532061936Li M, Chen X, Wang H, Jurado KA, Engelman AN, Craigie RJournal of molecular biologyA Peptide Derived from Lens Epithelium-Derived Growth Factor Stimulates HIV-1 DNA Integration and Facilitates Intasome Structural Studies. J Mol Biol. 2020 03 27; 432(7):2055-2066.J Mol Biol2020-02-13T00:00:002020A Peptide Derived from Lens Epithelium-Derived Growth Factor Stimulates HIV-1 DNA Integration and Facilitates Intasome Structural Studies.Authorship 1288745Authorship 1231439832152226Chaudhuri E, Dash S, Balasubramaniam M, Padron A, Holland J, Sowd GA, Villalta F, Engelman AN, Pandhare J, Dash CThe Journal of biological chemistryThe HIV-1 capsid-binding host factor CPSF6 is post-transcriptionally regulated by the cellular microRNA miR-125b. J Biol Chem. 2020 04 10; 295(15):5081-5094.J Biol Chem2020-03-09T00:00:002020The HIV-1 capsid-binding host factor CPSF6 is post-transcriptionally regulated by the cellular microRNA miR-125b.Authorship 1263191Authorship 1254496132506843Engelman AN, Cherepanov PThe FEBS journalClose-up: HIV/SIV intasome structures shed new light on integrase inhibitor binding and viral escape mechanisms. FEBS J. 2021 01; 288(2):427-433.FEBS J2020-06-22T00:00:002020Close-up: HIV/SIV intasome structures shed new light on integrase inhibitor binding and viral escape mechanisms.Authorship 12697671032665593Francis AC, Marin M, Singh PK, Achuthan V, Prellberg MJ, Palermino-Rowland K, Lan S, Tedbury PR, Sarafianos SG, Engelman AN, Melikyan GBNature communicationsHIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains. Nat Commun. 2020 07 14; 11(1):3505.Nat Commun2020-07-14T00:00:002020HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains.Authorship 1708922Authorship 12741651132747784Ni T, Gerard S, Zhao G, Dent K, Ning J, Zhou J, Shi J, Anderson-Daniels J, Li W, Jang S, Engelman AN, Aiken C, Zhang PNature structural & molecular biologyIntrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A. Nat Struct Mol Biol. 2020 09; 27(9):855-862.Nat Struct Mol Biol2020-08-03T00:00:002020Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A.Authorship 1960501Authorship 12796692432848246Jiang C, Lian X, Gao C, Sun X, Einkauf KB, Chevalier JM, Chen SMY, Hua S, Rhee B, Chang K, Blackmer JE, Osborn M, Peluso MJ, Hoh R, Somsouk M, Milush J, Bertagnolli LN, Sweet SE, Varriale JA, Burbelo PD, Chun TW, Laird GM, Serrao E, Engelman AN, Carrington M, Siliciano RF, Siliciano JM, Deeks SG, Walker BD, Lichterfeld M, Yu XGNatureDistinct viral reservoirs in individuals with spontaneous control of HIV-1. Nature. 2020 09; 585(7824):261-267.Nature2020-08-26T00:00:002020Distinct viral reservoirs in individuals with spontaneous control of HIV-1.abm317AbbasMohammadiAbbas Mohammadi, M.D.194431Mohammadi, AbbasResearch Fellow in MedicineAuthorship 1289793832960169Elliott JL, Eschbach JE, Koneru PC, Li W, Puray-Chavez M, Townsend D, Lawson DQ, Engelman AN, Kvaratskhelia M, Kutluay SBeLifeIntegrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis. Elife. 2020 09 22; 9.Elife2020-09-22T00:00:002020Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis.Authorship 12917041432994325Li W, Singh PK, Sowd GA, Bedwell GJ, Jang S, Achuthan V, Oleru AV, Wong D, Fadel HJ, Lee K, KewalRamani VN, Poeschla EM, Herschhorn A, Engelman ANmBioCPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration. mBio. 2020 09 29; 11(5).mBio2020-09-29T00:00:002020CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration.true1Assistant Professor of Medicine, Part-timeAssistant Professor of Medicine, Part-timeAuthorship 12949481433060363Bester SM, Wei G, Zhao H, Adu-Ampratwum D, Iqbal N, Courouble VV, Francis AC, Annamalai AS, Singh PK, Shkriabai N, Van Blerkom P, Morrison J, Poeschla EM, Engelman AN, Melikyan GB, Griffin PR, Fuchs JR, Asturias FJ, Kvaratskhelia MScience (New York, N.Y.)Structural and mechanistic bases for a potent HIV-1 capsid inhibitor. Science. 2020 10 16; 370(6514):360-364.Science2020-10-16T00:00:002020Structural and mechanistic bases for a potent HIV-1 capsid inhibitor.Authorship 1300110933115869Eschbach JE, Elliott JL, Li W, Zadrozny KK, Davis K, Mohammed SJ, Lawson DQ, Pornillos O, Engelman AN, Kutluay SBJournal of virologyCapsid Lattice Destabilization Leads to Premature Loss of the Viral Genome and Integrase Enzyme during HIV-1 Infection. J Virol. 2020 12 22; 95(2).J Virol2020-12-22T00:00:002020Capsid Lattice Destabilization Leads to Premature Loss of the Viral Genome and Integrase Enzyme during HIV-1 Infection.Authorship 2334624Authorship 13036641033244008Francis AC, Marin M, Singh PK, Achuthan V, Prellberg MJ, Palermino-Rowland K, Lan S, Tedbury PR, Sarafianos SG, Engelman AN, Melikyan GBNature communicationsPublisher Correction: HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains. Nat Commun. 2020 Nov 26; 11(1):6165.Nat Commun2020-11-26T00:00:002020Publisher Correction: HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains.33332391Xu C, Fischer DK, Rankovic S, Li W, Dick RA, Runge B, Zadorozhnyi R, Ahn J, Aiken C, Polenova T, Engelman AN, Ambrose Z, Rousso I, Perilla JRPLoS biologyPermeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis. PLoS Biol. 2020 12; 18(12):e3001015.PLoS Biol2020-12-17T00:00:002020Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis.33337475Bedwell GJ, Engelman ANNucleic acids researchFactors that mold the nuclear landscape of HIV-1 integration. Nucleic Acids Res. 2021 01 25; 49(2):621-635.Nucleic Acids Res2021-01-25T00:00:002021Factors that mold the nuclear landscape of HIV-1 integration.Authorship 131319211Authorship 13130122Authorship 1319466133477441Engelman ANVirusesHIV Capsid and Integration Targeting. Viruses. 2021 Jan 18; 13(1).Viruses2021-01-18T00:00:002021HIV Capsid and Integration Targeting.true1Associate Professor of MedicineAssociate Professor of MedicineAuthorship 2175995Authorship 1336008233649290Engelman KD, Engelman ANSignal transduction and targeted therapyD614G and SARS-CoV-2 replication fitness. Signal Transduct Target Ther. 2021 03 01; 6(1):99.Signal Transduct Target Ther2021-03-01T00:00:002021D614G and SARS-CoV-2 replication fitness.Authorship 1337847733712691Pandey KK, Bera S, Shi K, Rau MJ, Oleru AV, Fitzpatrick JAJ, Engelman AN, Aihara H, Grandgenett DPCommunications biologyCryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome. Commun Biol. 2021 03 12; 4(1):330.Commun Biol2021-03-12T00:00:002021Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome.Authorship 1342180933758083Zhong Z, Ning J, Boggs EA, Jang S, Wallace C, Telmer C, Bruchez MP, Ahn J, Engelman AN, Zhang P, Watkins SC, Ambrose ZmBioCytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner. mBio. 2021 03 23; 12(2).mBio2021-03-23T00:00:002021Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner.Authorship 1358651234029457Engelman KD, Engelman ANBiochemistryLong-Acting Cabotegravir for HIV/AIDS Prophylaxis. Biochemistry. 2021 06 08; 60(22):1731-1740.Biochemistry2021-05-24T00:00:002021Long-Acting Cabotegravir for HIV/AIDS Prophylaxis.Authorship 1360922234061028Bedwell GJ, Engelman ANeLifeYou can keep your coat on. Elife. 2021 06 01; 10.Elife2021-06-01T00:00:002021You can keep your coat on.true1Assistant Professor of MedicineAssistant Professor of Medicinetrue1Instructor in MedicineInstructor in MedicineAuthorship 13697825Authorship 13701105Authorship 1372827234244677Maertens GN, Engelman AN, Cherepanov PNature reviews. MicrobiologyStructure and function of retroviral integrase. Nat Rev Microbiol. 2022 01; 20(1):20-34.Nat Rev Microbiol2021-07-09T00:00:002021Structure and function of retroviral integrase.34154414Zheng Y, Schubert HL, Singh PK, Martins LJ, Engelman AN, D'Orso I, Hill CP, Planelles VmBioCleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal. mBio. 2021 06 29; 12(3):e0109821.mBio2021-06-22T00:00:002021Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal.34165568Bedwell GJ, Jang S, Li W, Singh PK, Engelman ANNucleic acids researchrigrag: high-resolution mapping of genic targeting preferences during HIV-1 integration in vitro and in vivo. Nucleic Acids Res. 2021 07 21; 49(13):7330-7346.Nucleic Acids Res2021-07-21T00:00:002021rigrag: high-resolution mapping of genic targeting preferences during HIV-1 integration in vitro and in vivo.Authorship 1377469834293041Maehigashi T, Ahn S, Kim UI, Lindenberger J, Oo A, Koneru PC, Mahboubi B, Engelman AN, Kvaratskhelia M, Kim K, Kim BPLoS pathogensA highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site. PLoS Pathog. 2021 07; 17(7):e1009671.PLoS Pathog2021-07-22T00:00:002021A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site.Authorship 1390265834469717Ratnapriya S, Harris M, Chov A, Herbert ZT, Vrbanac V, Deruaz M, Achuthan V, Engelman AN, Sodroski J, Herschhorn ACell reportsIntra- and extra-cellular environments contribute to the fate of HIV-1 infection. Cell Rep. 2021 08 31; 36(9):109622.Cell Rep2021-08-31T00:00:002021Intra- and extra-cellular environments contribute to the fate of HIV-1 infection.Authorship 14116316Authorship 1412924534765089Rey JS, Li W, Bryer AJ, Beatson H, Lantz C, Engelman AN, Perilla JRComputational and structural biotechnology journalDeep-learning in situ classification of HIV-1 virion morphology. Comput Struct Biotechnol J. 2021; 19:5688-5700.Comput Struct Biotechnol J2021-10-05T00:00:002021Deep-learning in situ classification of HIV-1 virion morphology.34809662Liu S, Koneru PC, Li W, Pathirage C, Engelman AN, Kvaratskhelia M, Musier-Forsyth KRetrovirologyHIV-1 integrase binding to genomic RNA 5'-UTR induces local structural changes in vitro and in virio. Retrovirology. 2021 11 22; 18(1):37.Retrovirology2021-11-22T00:00:002021HIV-1 integrase binding to genomic RNA 5'-UTR induces local structural changes in vitro and in virio.true1Instructor in MedicineInstructor in MedicineAuthorship 198294true1Professor of MedicineProfessor of Medicinetrue1Professor of MedicineProfessor of MedicineAuthorship 1435992335203306Singh PK, Bedwell GJ, Engelman ANCellsSpatial and Genomic Correlates of HIV-1 Integration Site Targeting. Cells. 2022 02 14; 11(4).Cells2022-02-14T00:00:002022Spatial and Genomic Correlates of HIV-1 Integration Site Targeting.Authorship 14494091935504909Ballandras-Colas A, Chivukula V, Gruszka DT, Shan Z, Singh PK, Pye VE, McLean RK, Bedwell GJ, Li W, Nans A, Cook NJ, Fadel HJ, Poeschla EM, Griffiths DJ, Vargas J, Taylor IA, Lyumkis D, Yardimci H, Engelman AN, Cherepanov PNature communicationsMultivalent interactions essential for lentiviral integrase function. Nat Commun. 2022 05 03; 13(1):2416.Nat Commun2022-05-03T00:00:002022Multivalent interactions essential for lentiviral integrase function.Authorship 3353756Authorship 14659639Authorship 1464500135713529Zhang Q, Wang S, Li W, Yau E, Hui H, Singh PK, Achuthan V, Young Karris MA, Engelman AN, Rana TMNucleic acids researchGenome-wide CRISPR/Cas9 transcriptional activation screen identifies a histone acetyltransferase inhibitor complex as a regulator of HIV-1 integration. Nucleic Acids Res. 2022 07 08; 50(12):6687-6701.Nucleic Acids Res2022-07-08T00:00:002022Genome-wide CRISPR/Cas9 transcriptional activation screen identifies a histone acetyltransferase inhibitor complex as a regulator of HIV-1 integration.35632668Engelman AN, Kvaratskhelia MVirusesMultimodal Functionalities of HIV-1 Integrase. Viruses. 2022 04 28; 14(5).Viruses2022-04-28T00:00:002022Multimodal Functionalities of HIV-1 Integrase.Authorship 3981375Authorship 14898629Authorship 15004196Authorship 14913596Authorship 14863001536146690Singh PK, Li W, Bedwell GJ, Fadel HJ, Poeschla EM, Engelman ANVirusesAllosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors. Viruses. 2022 08 26; 14(9).Viruses2022-08-26T00:00:002022Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors.36202818Wei G, Iqbal N, Courouble VV, Francis AC, Singh PK, Hudait A, Annamalai AS, Bester S, Huang SW, Shkriabai N, Briganti L, Haney R, KewalRamani VN, Voth GA, Engelman AN, Melikyan GB, Griffin PR, Asturias F, Kvaratskhelia MNature communicationsPrion-like low complexity regions enable avid virus-host interactions during HIV-1 infection. Nat Commun. 2022 10 06; 13(1):5879.Nat Commun2022-10-06T00:00:002022Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection.35951676Francis AC, Cereseto A, Singh PK, Shi J, Poeschla E, Engelman AN, Aiken C, Melikyan GBPLoS pathogensLocalization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles. PLoS Pathog. 2022 08; 18(8):e1010754.PLoS Pathog2022-08-11T00:00:002022Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles.35947647Józwik IK, Li W, Zhang DW, Wong D, Grawenhoff J, Ballandras-Colas A, Aiyer S, Cherepanov P, Engelman AN, Lyumkis DNucleic acids researchB-to-A transition in target DNA during retroviral integration. Nucleic Acids Res. 2022 Aug 26; 50(15):8898-8918.Nucleic Acids Res2022-08-26T00:00:002022B-to-A transition in target DNA during retroviral integration.Authorship 4583976Authorship 152559811Authorship 15267871136744954Singer MR, Dinh T, Levintov L, Annamalai AS, Rey JS, Briganti L, Cook NJ, Pye VE, Taylor IA, Kim K, Engelman AN, Kim B, Perilla JR, Kvaratskhelia M, Cherepanov PmBioThe Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function. mBio. 2023 02 28; 14(1):e0356022.mBio2023-02-06T00:00:002023The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function.36807645Shen Q, Feng Q, Wu C, Xiong Q, Tian T, Yuan S, Shi J, Bedwell GJ, Yang R, Aiken C, Engelman AN, Lusk CP, Lin C, Xiong YNature structural & molecular biologyModeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels. Nat Struct Mol Biol. 2023 04; 30(4):425-435.Nat Struct Mol Biol2023-02-20T00:00:002023Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels.Authorship 15340981936943880Shen Q, Kumari S, Xu C, Jang S, Shi J, Burdick RC, Levintov L, Xiong Q, Wu C, Devarkar SC, Tian T, Tripler TN, Hu Y, Yuan S, Temple J, Feng Q, Lusk CP, Aiken C, Engelman AN, Perilla JR, Pathak VK, Lin C, Xiong YProceedings of the National Academy of Sciences of the United States of AmericaThe capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores. Proc Natl Acad Sci U S A. 2023 03 28; 120(13):e2202815120.Proc Natl Acad Sci U S A2023-03-21T00:00:002023The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores.Ragon Institute of MGH, MIT and HarvardAuthorship 15635703437034605Mohammadi A, Etemad B, Zhang X, Li Y, Bedwell GJ, Sharaf R, Kittilson A, Melberg M, Wong C, Fajnzylber J, Worrall DP, Rosenthal A, Jordan H, Jilg N, Kaseke C, Giguel F, Lian X, Deo R, Gillespie E, Chishti R, Abrha S, Adams T, Siagian A, Anderson PL, Deeks SG, Lederman MM, Yawetz S, Kuritzkes DR, Lichterfeld MD, Tsibris A, Carrington M, Brumme ZL, Castillo-Mancilla JR, Engelman AN, Gaiha GD, Li JZmedRxiv : the preprint server for health sciencesViral and Host Mediators of Non-Suppressible HIV-1 Viremia. medRxiv. 2023 Mar 31.medRxiv2023-03-31T00:00:002023Viral and Host Mediators of Non-Suppressible HIV-1 Viremia.37707858Irie WC, Chitneni P, Glynn TR, Allen W, Chai PR, Engelman AN, Hurtado R, Li JZ, Li P, Lockman S, Marcus JL, Ogunshola FJ, Rönn MM, Haberer J, Ghebremichael M, Ciaranello AJournal of acquired immune deficiency syndromes (1999)Pathways and Intersections: Multifaceted Approaches to Engage Individuals From Underrepresented and Marginalized Communities in HIV Research and Career Development. J Acquir Immune Defic Syndr. 2023 10 01; 94(2S):S116-S121.J Acquir Immune Defic Syndr2023-10-01T00:00:002023Pathways and Intersections: Multifaceted Approaches to Engage Individuals From Underrepresented and Marginalized Communities in HIV Research and Career Development.Authorship 15829472Authorship 1588015637750702Jang S, Engelman ANMicrobiology and molecular biology reviews : MMBRCapsid-host interactions for HIV-1 ingress. Microbiol Mol Biol Rev. 2023 Dec 20; 87(4):e0004822.Microbiol Mol Biol Rev2023-09-26T00:00:002023Capsid-host interactions for HIV-1 ingress.true1Research Fellow in MedicineResearch Fellow in Medicinetrue1William Bosworth Castle Professor of MedicineWilliam Bosworth Castle Professor of Medicinetrue1Phillip T. and Susan M. Ragon Professor of MedicinePhillip T. and Susan M. Ragon Professor of MedicineAuthorship 16099623837957382Mohammadi A, Etemad B, Zhang X, Li Y, Bedwell GJ, Sharaf R, Kittilson A, Melberg M, Crain CR, Traunbauer AK, Wong C, Fajnzylber J, Worrall DP, Rosenthal A, Jordan H, Jilg N, Kaseke C, Giguel F, Lian X, Deo R, Gillespie E, Chishti R, Abrha S, Adams T, Siagian A, Dorazio D, Anderson PL, Deeks SG, Lederman MM, Yawetz S, Kuritzkes DR, Lichterfeld MD, Sieg S, Tsibris A, Carrington M, Brumme ZL, Castillo-Mancilla JR, Engelman AN, Gaiha GD, Li JZNature medicineViral and host mediators of non-suppressible HIV-1 viremia. Nat Med. 2023 Dec; 29(12):3212-3223.Nat Med2023-11-13T00:00:002023Viral and host mediators of non-suppressible HIV-1 viremia.Authorship 16279921638328132Jing T, Shan Z, Dinh T, Biswas A, Jang S, Greenwood J, Li M, Zhang Z, Gray G, Shin HJ, Zhou B, Passos D, Aiyer S, Li Z, Craigie R, Engelman AN, Kvaratskhelia M, Lyumkis DbioRxiv : the preprint server for biologyOligomeric HIV-1 Integrase Structures Reveal Functional Plasticity for Intasome Assembly and RNA Binding. bioRxiv. 2024 Jan 27.bioRxiv2024-01-27T00:00:002024Oligomeric HIV-1 Integrase Structures Reveal Functional Plasticity for Intasome Assembly and RNA Binding.Authorship 1765954true1Associate Professor of MedicineAssociate Professor of MedicineAuthorship 5720284Authorship 2511775Authorship 4903813Authorship 65942312Authorship 6680891Authorship 6498741123615903Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, Larue RC, Patel PA, Mitsuya H, Kessl JJ, Engelman A, Fuchs JR, Kvaratskhelia MThe Journal of biological chemistryThe A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors. J Biol Chem. 2013 May 31; 288(22):15813-20.J Biol Chem2013-04-24T00:00:002013The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.23647983Engelman A, Kessl JJ, Kvaratskhelia MCurrent opinion in chemical biologyAllosteric inhibition of HIV-1 integrase activity. Curr Opin Chem Biol. 2013 Jun; 17(3):339-45.Curr Opin Chem Biol2013-05-03T00:00:002013Allosteric inhibition of HIV-1 integrase activity.23610442Jurado KA, Wang H, Slaughter A, Feng L, Kessl JJ, Koh Y, Wang W, Ballandras-Colas A, Patel PA, Fuchs JR, Kvaratskhelia M, Engelman AProceedings of the National Academy of Sciences of the United States of AmericaAllosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):8690-5.Proc Natl Acad Sci U S A2013-04-22T00:00:002013Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.Authorship 5081161Authorship 2306271Authorship 25091913Authorship 6801455Authorship 679523224124581Ballandras-Colas A, Naraharisetty H, Li X, Serrao E, Engelman APloS oneBiochemical characterization of novel retroviral integrase proteins. PLoS One. 2013; 8(10):e76638.PLoS One2013-10-04T00:00:002013Biochemical characterization of novel retroviral integrase proteins.24103892Matreyek KA, Engelman AVirusesViral and cellular requirements for the nuclear entry of retroviral preintegration nucleoprotein complexes. Viruses. 2013 Oct 07; 5(10):2483-511.Viruses2013-10-07T00:00:002013Viral and cellular requirements for the nuclear entry of retroviral preintegration nucleoprotein complexes.Authorship 681217424130490Matreyek KA, Yücel SS, Li X, Engelman APLoS pathogensNucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity. PLoS Pathog. 2013; 9(10):e1003693.PLoS Pathog2013-10-10T00:00:002013Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity.Authorship 3155535Authorship 3504635Authorship 2186703Authorship 694534224274067Jurado KA, Engelman AExpert reviews in molecular medicineMultimodal mechanism of action of allosteric HIV-1 integrase inhibitors. Expert Rev Mol Med. 2013 Nov 26; 15:e14.Expert Rev Mol Med2013-11-26T00:00:002013Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors.Authorship 3815295Authorship 3826789Authorship 4023259Authorship 2644582Authorship 2884574Authorship 7211291324449914Maertens GN, Cook NJ, Wang W, Hare S, Gupta SS, Öztop I, Lee K, Pye VE, Cosnefroy O, Snijders AP, KewalRamani VN, Fassati A, Engelman A, Cherepanov PProceedings of the National Academy of Sciences of the United States of AmericaStructural basis for nuclear import of splicing factors by human Transportin 3. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2728-33.Proc Natl Acad Sci U S A2014-01-21T00:00:002014Structural basis for nuclear import of splicing factors by human Transportin 3.Authorship 2338034Authorship 2651238Authorship 726523624520116Serrao E, Krishnan L, Shun MC, Li X, Cherepanov P, Engelman A, Maertens GNNucleic acids researchIntegrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding. Nucleic Acids Res. 2014 Apr; 42(8):5164-76.Nucleic Acids Res2014-02-11T00:00:002014Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding.Authorship 1824682Authorship 3838358Authorship 3986595Authorship 35927412Authorship 746590425119883Li M, Jurado KA, Lin S, Engelman A, Craigie RPloS oneEngineered hyperactive integrase for concerted HIV-1 DNA integration. PLoS One. 2014; 9(8):e105078.PLoS One2014-08-13T00:00:002014Engineered hyperactive integrase for concerted HIV-1 DNA integration.Authorship 757897525147212Kvaratskhelia M, Sharma A, Larue RC, Serrao E, Engelman ANucleic acids researchMolecular mechanisms of retroviral integration site selection. Nucleic Acids Res. 2014; 42(16):10209-25.Nucleic Acids Res2014-08-21T00:00:002014Molecular mechanisms of retroviral integration site selection.Authorship 3958835Authorship 970523Authorship 4247893Authorship 774379925312384Fribourgh JL, Nguyen HC, Matreyek KA, Alvarez FJD, Summers BJ, Dewdney TG, Aiken C, Zhang P, Engelman A, Xiong YCell host & microbeStructural insight into HIV-1 restriction by MxB. Cell Host Microbe. 2014 Nov 12; 16(5):627-638.Cell Host Microbe2014-10-09T00:00:002014Structural insight into HIV-1 restriction by MxB.Authorship 4515991Authorship 49309420Authorship 828004Authorship 91161Authorship 725044Authorship 4359711Authorship 5153804Authorship 4945364Authorship 1756371Authorship 1683531Authorship 4230123Authorship 5335312Authorship 230261Authorship 829161Authorship 3589481Authorship 414824Authorship 3127172Authorship 3656944Authorship 5039591Authorship 2304222Authorship 26468310Authorship 3158261Authorship 364906Authorship 4392648Authorship 2116564Authorship 223945Authorship 2490465Authorship 4600711Authorship 49241110Authorship 5078924Authorship 7941895Authorship 80424314Authorship 8011433Authorship 797224625707795Nuñez JK, Lee AS, Engelman A, Doudna JANatureIntegrase-mediated spacer acquisition during CRISPR-Cas adaptive immunity. Nature. 2015 Mar 12; 519(7542):193-8.Nature2015-02-18T00:00:002015Integrase-mediated spacer acquisition during CRISPR-Cas adaptive immunity.25924943Serrao E, Ballandras-Colas A, Cherepanov P, Maertens GN, Engelman ANRetrovirologyKey determinants of target DNA recognition by retroviral intasomes. Retrovirology. 2015 Apr 30; 12:39.Retrovirology2015-04-30T00:00:002015Key determinants of target DNA recognition by retroviral intasomes.25421939Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia MRetrovirologyThe mechanism of H171T resistance reveals the importance of Nd-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase. Retrovirology. 2014 Nov 25; 11:100.Retrovirology2014-11-25T00:00:002014The mechanism of H171T resistance reveals the importance of Nd-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.25348155Matreyek KA, Wang W, Serrao E, Singh PK, Levin HL, Engelman ARetrovirologyHost and viral determinants for MxB restriction of HIV-1 infection. Retrovirology. 2014 Oct 25; 11:90.Retrovirology2014-10-25T00:00:002014Host and viral determinants for MxB restriction of HIV-1 infection.Authorship 966341Authorship 5306875Authorship 5457286Authorship 4230971Palliative CareAuthorship 809019126104441Engelman A, Cherepanov PMicrobiology spectrumRetroviral Integrase Structure and DNA Recombination Mechanism. Microbiol Spectr. 2014 Dec; 2(6).Microbiol Spectr2014-12-01T00:00:002014Retroviral Integrase Structure and DNA Recombination Mechanism.Authorship 48352Authorship 815887826061770Maskell DP, Renault L, Serrao E, Lesbats P, Matadeen R, Hare S, Lindemann D, Engelman AN, Costa A, Cherepanov PNatureStructural basis for retroviral integration into nucleosomes. Nature. 2015 Jul 16; 523(7560):366-9.Nature2015-06-10T00:00:002015Structural basis for retroviral integration into nucleosomes.Authorship 3394332Authorship 831580726178982Fontana J, Jurado KA, Cheng N, Ly NL, Fuchs JR, Gorelick RJ, Engelman AN, Steven ACJournal of virologyDistribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation. J Virol. 2015 Oct; 89(19):9765-80.J Virol2015-07-15T00:00:002015Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation.Authorship 835866426367869Wang H, Shun MC, Dickson AK, Engelman ANPloS oneEmbryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice. PLoS One. 2015; 10(9):e0137797.PLoS One2015-09-14T00:00:002015Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice.Authorship 8632Authorship 4353334Authorship 4945309Authorship 848794426503043Nuñez JK, Harrington LB, Kranzusch PJ, Engelman AN, Doudna JANatureForeign DNA capture during CRISPR-Cas adaptive immunity. Nature. 2015 Nov 26; 527(7579):535-8.Nature2015-10-21T00:00:002015Foreign DNA capture during CRISPR-Cas adaptive immunity.Authorship 5007033Authorship 512821Authorship 8694008Authorship 8674527Authorship 870548226887496Ballandras-Colas A, Brown M, Cook NJ, Dewdney TG, Demeler B, Cherepanov P, Lyumkis D, Engelman ANNatureCryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature. 2016 Feb 18; 530(7590):358-61.Nature2016-02-18T00:00:002016Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.26858452Sowd GA, Serrao E, Wang H, Wang W, Fadel HJ, Poeschla EM, Engelman ANProceedings of the National Academy of Sciences of the United States of AmericaA critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin. Proc Natl Acad Sci U S A. 2016 Feb 23; 113(8):E1054-63.Proc Natl Acad Sci U S A2016-02-08T00:00:002016A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin.26508664Serrao E, Engelman ANCritical reviews in biochemistry and molecular biologySites of retroviral DNA integration: From basic research to clinical applications. Crit Rev Biochem Mol Biol. 2016; 51(1):26-42.Crit Rev Biochem Mol Biol2015-10-28T00:00:002015Sites of retroviral DNA integration: From basic research to clinical applications.Authorship 78624Authorship 925771Authorship 875100327023428Serrao E, Cherepanov P, Engelman ANJournal of visualized experiments : JoVEAmplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites. J Vis Exp. 2016 Mar 22; (109).J Vis Exp2016-03-22T00:00:002016Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites.Authorship 3917193SJ198SooinJangSooin Jang, Ph.D.147620Jang, SooinInstructor in MedicineAuthorship 4608066Authorship 5034162Authorship 8814701226910179Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia MACS chemical biologyThe Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency. ACS Chem Biol. 2016 05 20; 11(5):1313-21.ACS Chem Biol2016-03-02T00:00:002016The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.Authorship 88480710Authorship 884529826994143Rasheedi S, Shun MC, Serrao E, Sowd GA, Qian J, Hao C, Dasgupta T, Engelman AN, Skowronski JThe Journal of biological chemistryThe Cleavage and Polyadenylation Specificity Factor 6 (CPSF6) Subunit of the Capsid-recruited Pre-messenger RNA Cleavage Factor I (CFIm) Complex Mediates HIV-1 Integration into Genes. J Biol Chem. 2016 May 27; 291(22):11809-19.J Biol Chem2016-03-18T00:00:002016The Cleavage and Polyadenylation Specificity Factor 6 (CPSF6) Subunit of the Capsid-recruited Pre-messenger RNA Cleavage Factor I (CFIm) Complex Mediates HIV-1 Integration into Genes.27076642Saito A, Ferhadian D, Sowd GA, Serrao E, Shi J, Halambage UD, Teng S, Soto J, Siddiqui MA, Engelman AN, Aiken C, Yamashita MJournal of virologyRoles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74. J Virol. 2016 06 15; 90(12):5808-5823.J Virol2016-05-27T00:00:002016Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74.Authorship 941022Authorship 57362592Assistant Professor1Associate Professor6Fellow or Post Doc0Full Professor4Instructor5Other FacultyAuthorship 8919861427307565Saito A, Henning MS, Serrao E, Dubose BN, Teng S, Huang J, Li X, Saito N, Roy SP, Siddiqui MA, Ahn J, Tsuji M, Hatziioannou T, Engelman AN, Yamashita MJournal of virologyCapsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus Passage In Vivo. J Virol. 2016 08 01; 90(15):6918-6935.J Virol2016-07-11T00:00:002016Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus Passage In Vivo.Authorship 673787Authorship 5606891Authorship 90969613Authorship 910333727579920Zurnic I, Hütter S, Rzeha U, Stanke N, Reh J, Müllers E, Hamann MV, Kern T, Gerresheim GK, Lindel F, Serrao E, Lesbats P, Engelman AN, Cherepanov P, Lindemann DPLoS pathogensInteractions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration. PLoS Pathog. 2016 08; 12(8):e1005860.PLoS Pathog2016-08-31T00:00:002016Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration.27356901Zerbato JM, Serrao E, Lenzi G, Kim B, Ambrose Z, Watkins SC, Engelman AN, Sluis-Cremer NJournal of virologyEstablishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+ T Cells In Vitro. J Virol. 2016 09 15; 90(18):8059-73.J Virol2016-08-26T00:00:002016Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+ T Cells In Vitro.Authorship 53750832027-05-31ENGELMAN, ALAN N.2002-04-01HIV-1 Preintegration Trafficking and Nuclear LocalizationR01AI0520142017-08-31OLSON, ARTHUR J.2012-09-01HIV Macromolecular Interactions and Impact on Viral Evolution of Drug ResistanceP50GM1033682021-03-31ENGELMAN, ALAN N.2006-04-01Integrase Structural VirologyR01AI0700422003-04-30ENGELMAN, ALAN N.1999-09-01MECHANISM OF NON-INTEGRASE-MEDIATED HIV-1 REPLICATIONR01AI0453132004-08-31ENGELMAN, ALAN N.2002-09-20Biochemical Mechanism of HIV DNA IntegrationR21AI0538122010-05-31ENGELMAN, ALAN N.1996-07-01Biochemical Mechanism of HIV DNA IntegrationR01AI0393942025-05-31ENGELMAN, ALAN N.1996-07-01Biochemical Mechanism of HIV DNA IntegrationR37AI0393942006-06-30ENGELMAN, ALAN N.2004-07-01LEDGF-Integrase Structural BiologyR21AI0622492024-05-31CANTOR, HARVEY ;ENGELMAN, ALAN N.1990-08-01Postdoctoral Training Program in AIDS-related ResearchT32AI0073862000-04-30ENGELMAN, ALAN N.1999-05-01MECHANISM OF NONINTEGRASE MEDIATED HIV1 REPLICATIONR21AI045313Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorAuthorship 674575Authorship 927511Authorship 915683Authorship 9242261Authorship 92878514Authorship 92452412Authorship 922467725705574Engelman A, Cherepanov PMicrobiology spectrumRetroviral Integrase Structure and DNA Recombination Mechanism. Microbiol Spectr. 2014; 2(6):1-22.Microbiol Spectr2014-01-01T00:00:002014Retroviral Integrase Structure and DNA Recombination Mechanism.25383358Wang H, Shun MC, Li X, Di Nunzio F, Hare S, Cherepanov P, Engelman AMolecular therapy. Methods & clinical developmentEfficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses. Mol Ther Methods Clin Dev. 2014 Jan 08; 1.Mol Ther Methods Clin Dev2014-01-08T00:00:002014Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses.27723818Zurnic I, Hütter S, Rzeha U, Helbig R, Stanke N, Reh J, Müllers E, Hamann MV, Kern T, Gerresheim GK, Lindel F, Serrao E, Lesbats P, Engelman AN, Cherepanov P, Lindemann DPLoS pathogensCorrection: Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration. PLoS Pathog. 2016 Oct; 12(10):e1005956.PLoS Pathog2016-10-10T00:00:002016Correction: Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration.27645997Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold EThe Journal of biological chemistryA New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain. J Biol Chem. 2016 Nov 04; 291(45):23569-23577.J Biol Chem2016-09-19T00:00:002016A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.Authorship 5608563Authorship 9331082Authorship 930650627198982Lesbats P, Engelman AN, Cherepanov PChemical reviewsRetroviral DNA Integration. Chem Rev. 2016 10 26; 116(20):12730-12757.Chem Rev2016-05-20T00:00:002016Retroviral DNA Integration.27503276Deng N, Hoyte A, Mansour YE, Mohamed MS, Fuchs JR, Engelman AN, Kvaratskhelia M, Levy RProtein science : a publication of the Protein SocietyAllosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies. Protein Sci. 2016 11; 25(11):1911-1917.Protein Sci2016-08-17T00:00:002016Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies.Authorship 706604Authorship 35314111Authorship 39174310Authorship 942483928009288Lu YF, Cahan P, Ross S, Sahalie J, Sousa PM, Hadland BK, Cai W, Serrao E, Engelman AN, Bernstein ID, Daley GQCell reportsEngineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity. Cell Rep. 2016 12 20; 17(12):3178-3192.Cell Rep2016-12-20T00:00:002016Engineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity.Authorship 4034892Authorship 4462244Authorship 9469111228059770Ballandras-Colas A, Maskell DP, Serrao E, Locke J, Swuec P, Jónsson SR, Kotecha A, Cook NJ, Pye VE, Taylor IA, Andrésdóttir V, Engelman AN, Costa A, Cherepanov PScience (New York, N.Y.)A supramolecular assembly mediates lentiviral DNA integration. Science. 2017 01 06; 355(6320):93-95.Science2017-01-06T00:00:002017A supramolecular assembly mediates lentiviral DNA integration.Authorship 52414719343162Du Z, Ilyinskii PO, Lally K, Desrosiers RC, Engelman AJournal of virologyA mutation in integrase can compensate for mutations in the simian immunodeficiency virus att site. J Virol. 1997 Nov; 71(11):8124-32.J Virol1997-11-01T00:00:001997A mutation in integrase can compensate for mutations in the simian immunodeficiency virus att site.11564861Chen H, Engelman AMolecular and cellular biologyAsymmetric processing of human immunodeficiency virus type 1 cDNA in vivo: implications for functional end coupling during the chemical steps of DNA transposition. Mol Cell Biol. 2001 Oct; 21(20):6758-67.Mol Cell Biol2001-10-01T00:00:002001Asymmetric processing of human immunodeficiency virus type 1 cDNA in vivo: implications for functional end coupling during the chemical steps of DNA transposition.12414949Limón A, Nakajima N, Lu R, Ghory HZ, Engelman AJournal of virologyWild-type levels of nuclear localization and human immunodeficiency virus type 1 replication in the absence of the central DNA flap. J Virol. 2002 Dec; 76(23):12078-86.J Virol2002-12-01T00:00:002002Wild-type levels of nuclear localization and human immunodeficiency virus type 1 replication in the absence of the central DNA flap.15163664Maertens G, Cherepanov P, Debyser Z, Engelborghs Y, Engelman AThe Journal of biological chemistryIdentification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75. J Biol Chem. 2004 Aug 06; 279(32):33421-9.J Biol Chem2004-05-25T00:00:002004Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75.8970947Taddeo B, Carlini F, Verani P, Engelman AJournal of virologyReversion of a human immunodeficiency virus type 1 integrase mutant at a second site restores enzyme function and virus infectivity. J Virol. 1996 Dec; 70(12):8277-84.J Virol1996-12-01T00:00:001996Reversion of a human immunodeficiency virus type 1 integrase mutant at a second site restores enzyme function and virus infectivity.GJB16GregoryBedwellGregory Bedwell, Ph.D.156335Bedwell, GregoryInstructor in Medicine13130095Devroe E, Engelman A, Silver PAJournal of cell scienceIntracellular transport of human immunodeficiency virus type 1 integrase. J Cell Sci. 2003 Nov 01; 116(Pt 21):4401-8.J Cell Sci2003-09-16T00:00:002003Intracellular transport of human immunodeficiency virus type 1 integrase.PS308ParmitSinghParmit Singh, Ph.D.156683Singh, ParmitResearch Associate in MedicineAuthorship 969545728202766Wang W, Zhou J, Halambage UD, Jurado KA, Jamin AV, Wang Y, Engelman AN, Aiken CJournal of virologyInhibition of HIV-1 Maturation via Small-Molecule Targeting of the Amino-Terminal Domain in the Viral Capsid Protein. J Virol. 2017 05 01; 91(9).J Virol2017-04-13T00:00:002017Inhibition of HIV-1 Maturation via Small-Molecule Targeting of the Amino-Terminal Domain in the Viral Capsid Protein.Authorship 970600228289517Grawenhoff J, Engelman ANWorld journal of biological chemistryRetroviral integrase protein and intasome nucleoprotein complex structures. World J Biol Chem. 2017 Feb 26; 8(1):32-44.World J Biol Chem2017-02-26T00:00:002017Retroviral integrase protein and intasome nucleoprotein complex structures.18801737McKee CJ, Kessl JJ, Shkriabai N, Dar MJ, Engelman A, Kvaratskhelia MThe Journal of biological chemistryDynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein. J Biol Chem. 2008 Nov 14; 283(46):31802-12.J Biol Chem2008-09-18T00:00:002008Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein.19233280Engelman A, Oztop I, Vandegraaff N, Raghavendra NKMethods (San Diego, Calif.)Quantitative analysis of HIV-1 preintegration complexes. Methods. 2009 Apr; 47(4):283-90.Methods2009-02-20T00:00:002009Quantitative analysis of HIV-1 preintegration complexes.19389610Engelman AMethods (San Diego, Calif.)Mechanistic and pharmacological analyses of HIV-1 integration. Methods. 2009 Apr; 47(4):225-8.Methods2009-04-01T00:00:002009Mechanistic and pharmacological analyses of HIV-1 integration.15895093Cherepanov P, Sun ZY, Rahman S, Maertens G, Wagner G, Engelman ANature structural & molecular biologySolution structure of the HIV-1 integrase-binding domain in LEDGF/p75. Nat Struct Mol Biol. 2005 Jun; 12(6):526-32.Nat Struct Mol Biol2005-05-15T00:00:002005Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75.9362498Jenkins TM, Esposito D, Engelman A, Craigie RThe EMBO journalCritical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking. EMBO J. 1997 Nov 17; 16(22):6849-59.EMBO J1997-11-17T00:00:001997Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking.10933731Chen H, Engelman AJournal of virologyCharacterization of a replication-defective human immunodeficiency virus type 1 att site mutant that is blocked after the 3' processing step of retroviral integration. J Virol. 2000 Sep; 74(17):8188-93.J Virol2000-09-01T00:00:002000Characterization of a replication-defective human immunodeficiency virus type 1 att site mutant that is blocked after the 3' processing step of retroviral integration.17428871Mbisa JL, Barr R, Thomas JA, Vandegraaff N, Dorweiler IJ, Svarovskaia ES, Brown WL, Mansky LM, Gorelick RJ, Harris RS, Engelman A, Pathak VKJournal of virologyHuman immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration. J Virol. 2007 Jul; 81(13):7099-110.J Virol2007-04-11T00:00:002007Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration.8936591Engelman AProtein expression and purificationBiochemical characterization of recombinant equine infectious anemia virus integrase. Protein Expr Purif. 1996 Nov; 8(3):299-304.Protein Expr Purif1996-11-01T00:00:001996Biochemical characterization of recombinant equine infectious anemia virus integrase.9860958Chen H, Engelman AProceedings of the National Academy of Sciences of the United States of AmericaThe barrier-to-autointegration protein is a host factor for HIV type 1 integration. Proc Natl Acad Sci U S A. 1998 Dec 22; 95(26):15270-4.Proc Natl Acad Sci U S A1998-12-22T00:00:001998The barrier-to-autointegration protein is a host factor for HIV type 1 integration.20733078Krishnan L, Li X, Naraharisetty HL, Hare S, Cherepanov P, Engelman AProceedings of the National Academy of Sciences of the United States of AmericaStructure-based modeling of the functional HIV-1 intasome and its inhibition. Proc Natl Acad Sci U S A. 2010 Sep 07; 107(36):15910-5.Proc Natl Acad Sci U S A2010-08-23T00:00:002010Structure-based modeling of the functional HIV-1 intasome and its inhibition.44 Binney StDana Farber Cancer InstituteCls-101044 Binney StBoston02115MA17320002Vandegraaff N, Engelman AExpert reviews in molecular medicineMolecular mechanisms of HIV integration and therapeutic intervention. Expert Rev Mol Med. 2007 Feb 26; 9(6):1-19.Expert Rev Mol Med2007-02-26T00:00:002007Molecular mechanisms of HIV integration and therapeutic intervention.Authorship 9819627Authorship 9809121628514439Sugimura R, Jha DK, Han A, Soria-Valles C, da Rocha EL, Lu YF, Goettel JA, Serrao E, Rowe RG, Malleshaiah M, Wong I, Sousa P, Zhu TN, Ditadi A, Keller G, Engelman AN, Snapper SB, Doulatov S, Daley GQNatureHaematopoietic stem and progenitor cells from human pluripotent stem cells. Nature. 2017 05 25; 545(7655):432-438.Nature2017-05-17T00:00:002017Haematopoietic stem and progenitor cells from human pluripotent stem cells.28490494Lesbats P, Serrao E, Maskell DP, Pye VE, O'Reilly N, Lindemann D, Engelman AN, Cherepanov PProceedings of the National Academy of Sciences of the United States of AmericaStructural basis for spumavirus GAG tethering to chromatin. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):5509-5514.Proc Natl Acad Sci U S A2017-05-10T00:00:002017Structural basis for spumavirus GAG tethering to chromatin.9094622Engelman A, Liu Y, Chen H, Farzan M, Dyda FJournal of virologyStructure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase. J Virol. 1997 May; 71(5):3507-14.J Virol1997-05-01T00:00:001997Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase.12663813Lin CW, Engelman AJournal of virologyThe barrier-to-autointegration factor is a component of functional human immunodeficiency virus type 1 preintegration complexes. J Virol. 2003 Apr; 77(8):5030-6.J Virol2003-04-01T00:00:002003The barrier-to-autointegration factor is a component of functional human immunodeficiency virus type 1 preintegration complexes.19609359Hare S, Di Nunzio F, Labeja A, Wang J, Engelman A, Cherepanov PPLoS pathogensStructural basis for functional tetramerization of lentiviral integrase. PLoS Pathog. 2009 Jul; 5(7):e1000515.PLoS Pathog2009-07-17T00:00:002009Structural basis for functional tetramerization of lentiviral integrase.19846519Krishnan L, Matreyek KA, Oztop I, Lee K, Tipper CH, Li X, Dar MJ, Kewalramani VN, Engelman AJournal of virologyThe requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase. J Virol. 2010 Jan; 84(1):397-406.J Virol2009-10-21T00:00:002009The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase.16337983Vandegraaff N, Devroe E, Turlure F, Silver PA, Engelman AVirologyBiochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication. Virology. 2006 Mar 15; 346(2):415-26.Virology2005-12-09T00:00:002005Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication.Authorship 984203228528781Yamashita M, Engelman ANTrends in microbiologyCapsid-Dependent Host Factors in HIV-1 Infection. Trends Microbiol. 2017 09; 25(9):741-755.Trends Microbiol2017-05-18T00:00:002017Capsid-Dependent Host Factors in HIV-1 Infection.17287285Daelemans D, Lu R, De Clercq E, Engelman AJournal of virologyCharacterization of a replication-competent, integrase-defective human immunodeficiency virus (HIV)/simian virus 40 chimera as a powerful tool for the discovery and validation of HIV integrase inhibitors. J Virol. 2007 Apr; 81(8):4381-5.J Virol2007-02-07T00:00:002007Characterization of a replication-competent, integrase-defective human immunodeficiency virus (HIV)/simian virus 40 chimera as a powerful tool for the discovery and validation of HIV integrase inhibitors.18093980Zhao Z, McKee CJ, Kessl JJ, Santos WL, Daigle JE, Engelman A, Verdine G, Kvaratskhelia MThe Journal of biological chemistrySubunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding. J Biol Chem. 2008 Feb 29; 283(9):5632-41.J Biol Chem2007-12-19T00:00:002007Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding.15371438Cherepanov P, Devroe E, Silver PA, Engelman AThe Journal of biological chemistryIdentification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase. J Biol Chem. 2004 Nov 19; 279(47):48883-92.J Biol Chem2004-09-14T00:00:002004Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase.17035312Shun MC, Daigle JE, Vandegraaff N, Engelman AJournal of virologyWild-type levels of human immunodeficiency virus type 1 infectivity in the absence of cellular emerin protein. J Virol. 2007 Jan; 81(1):166-72.J Virol2006-10-11T00:00:002006Wild-type levels of human immunodeficiency virus type 1 infectivity in the absence of cellular emerin protein.10516007Brown HE, Chen H, Engelman AJournal of virologyStructure-based mutagenesis of the human immunodeficiency virus type 1 DNA attachment site: effects on integration and cDNA synthesis. J Virol. 1999 Nov; 73(11):9011-20.J Virol1999-11-01T00:00:001999Structure-based mutagenesis of the human immunodeficiency virus type 1 DNA attachment site: effects on integration and cDNA synthesis.15353349Turlure F, Devroe E, Silver PA, Engelman AFrontiers in bioscience : a journal and virtual libraryHuman cell proteins and human immunodeficiency virus DNA integration. Front Biosci. 2004 Sep 01; 9:3187-208.Front Biosci2004-09-01T00:00:002004Human cell proteins and human immunodeficiency virus DNA integration.Authorship 991179128458055Engelman AN, Cherepanov PCurrent opinion in structural biologyRetroviral intasomes arising. Curr Opin Struct Biol. 2017 12; 47:23-29.Curr Opin Struct Biol2017-04-28T00:00:002017Retroviral intasomes arising.15582665Devroe E, Silver PA, Engelman AVirologyHIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases. Virology. 2005 Jan 05; 331(1):181-9.Virology2005-01-05T00:00:002005HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases.7637039Engelman A, Craigie RJournal of virologyEfficient magnesium-dependent human immunodeficiency virus type 1 integrase activity. J Virol. 1995 Sep; 69(9):5908-11.J Virol1995-09-01T00:00:001995Efficient magnesium-dependent human immunodeficiency virus type 1 integrase activity.8152908Mazumder A, Engelman A, Craigie R, Fesen M, Pommier YNucleic acids researchIntermolecular disintegration and intramolecular strand transfer activities of wild-type and mutant HIV-1 integrase. Nucleic Acids Res. 1994 Mar 25; 22(6):1037-43.Nucleic Acids Res1994-03-25T00:00:001994Intermolecular disintegration and intramolecular strand transfer activities of wild-type and mutant HIV-1 integrase.17600205Engelman AScience (New York, N.Y.)AIDS/HIV. A reversal of fortune in HIV-1 integration. Science. 2007 Jun 29; 316(5833):1855-7.Science2007-06-29T00:00:002007AIDS/HIV. A reversal of fortune in HIV-1 integration.7707554Englund G, Theodore TS, Freed EO, Engelman A, Martin MAJournal of virologyIntegration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1. J Virol. 1995 May; 69(5):3216-9.J Virol1995-05-01T00:00:001995Integration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1.18187620Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJScience (New York, N.Y.)Identification of host proteins required for HIV infection through a functional genomic screen. Science. 2008 Feb 15; 319(5865):921-6.Science2008-01-10T00:00:002008Identification of host proteins required for HIV infection through a functional genomic screen.22301145Ambrose Z, Lee K, Ndjomou J, Xu H, Oztop I, Matous J, Takemura T, Unutmaz D, Engelman A, Hughes SH, KewalRamani VNJournal of virologyHuman immunodeficiency virus type 1 capsid mutation N74D alters cyclophilin A dependence and impairs macrophage infection. J Virol. 2012 Apr; 86(8):4708-14.J Virol2012-02-01T00:00:002012Human immunodeficiency virus type 1 capsid mutation N74D alters cyclophilin A dependence and impairs macrophage infection.23042676Wang H, Jurado KA, Wu X, Shun MC, Li X, Ferris AL, Smith SJ, Patel PA, Fuchs JR, Cherepanov P, Kvaratskhelia M, Hughes SH, Engelman ANucleic acids researchHRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. 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J Virol. 2004 Dec; 78(23):12735-46.J Virol2004-12-01T00:00:002004Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication.Authorship 1012012628929138Alvarez FJD, He S, Perilla JR, Jang S, Schulten K, Engelman AN, Scheres SHW, Zhang PScience advancesCryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction. Sci Adv. 2017 09; 3(9):e1701264.Sci Adv2017-09-15T00:00:002017CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction.Authorship 1015417728972144Hoyte AC, Jamin AV, Koneru PC, Kobe MJ, Larue RC, Fuchs JR, Engelman AN, Kvaratskhelia MThe Journal of biological chemistryResistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing. J Biol Chem. 2017 12 01; 292(48):19814-19825.J Biol Chem2017-09-28T00:00:002017Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing.7966578Vicenzi E, Dimitrov DS, Engelman A, Migone TS, Purcell DF, Leonard J, Englund G, Martin MAJournal of virologyAn integration-defective U5 deletion mutant of human immunodeficiency virus type 1 reverts by eliminating additional long terminal repeat sequences. J Virol. 1994 Dec; 68(12):7879-90.J Virol1994-12-01T00:00:001994An integration-defective U5 deletion mutant of human immunodeficiency virus type 1 reverts by eliminating additional long terminal repeat sequences.12932079Engelman ACurrent topics in microbiology and immunologyThe roles of cellular factors in retroviral integration. 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PLoS Pathog. 2009 Jan; 5(1):e1000259.PLoS Pathog2009-01-09T00:00:002009A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75.20118915Hare S, Gupta SS, Valkov E, Engelman A, Cherepanov PNatureRetroviral intasome assembly and inhibition of DNA strand transfer. Nature. 2010 Mar 11; 464(7286):232-6.Nature2010-01-31T00:00:002010Retroviral intasome assembly and inhibition of DNA strand transfer.17639082Shun MC, Raghavendra NK, Vandegraaff N, Daigle JE, Hughes S, Kellam P, Cherepanov P, Engelman AGenes & developmentLEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration. Genes Dev. 2007 Jul 15; 21(14):1767-78.Genes Dev2007-07-15T00:00:002007LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration.18174227Botbol Y, Raghavendra NK, Rahman S, Engelman A, Lavigne MNucleic acids researchChromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro. Nucleic Acids Res. 2008 Mar; 36(4):1237-46.Nucleic Acids Res2008-01-03T00:00:002008Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro.Authorship 10231261029084774El Ashkar S, Schwaller J, Pieters T, Goossens S, Demeulemeester J, Christ F, Van Belle S, Juge S, Boeckx N, Engelman A, Van Vlierberghe P, Debyser Z, De Rijck JBloodLEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis. Blood. 2018 01 04; 131(1):95-107.Blood2017-10-30T00:00:002017LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.1760846Engelman A, Mizuuchi K, Craigie RCellHIV-1 DNA integration: mechanism of viral DNA cleavage and DNA strand transfer. Cell. 1991 Dec 20; 67(6):1211-21.Cell1991-12-20T00:00:001991HIV-1 DNA integration: mechanism of viral DNA cleavage and DNA strand transfer.11005805Harris D, Engelman AThe Journal of biological chemistryBoth the structure and DNA binding function of the barrier-to-autointegration factor contribute to reconstitution of HIV type 1 integration in vitro. J Biol Chem. 2000 Dec 15; 275(50):39671-7.J Biol Chem2000-12-15T00:00:002000Both the structure and DNA binding function of the barrier-to-autointegration factor contribute to reconstitution of HIV type 1 integration in vitro.11483739Nakajima N, Lu R, Engelman AJournal of virologyHuman immunodeficiency virus type 1 replication in the absence of integrase-mediated dna recombination: definition of permissive and nonpermissive T-cell lines. J Virol. 2001 Sep; 75(17):7944-55.J Virol2001-09-01T00:00:002001Human immunodeficiency virus type 1 replication in the absence of integrase-mediated dna recombination: definition of permissive and nonpermissive T-cell lines.Authorship 1030195929192235Puray-Chavez M, Tedbury PR, Huber AD, Ukah OB, Yapo V, Liu D, Ji J, Wolf JJ, Engelman AN, Sarafianos SGNature communicationsMultiplex single-cell visualization of nucleic acids and protein during HIV infection. Nat Commun. 2017 12 01; 8(1):1882.Nat Commun2017-12-01T00:00:002017Multiplex single-cell visualization of nucleic acids and protein during HIV infection.16650449Diaz-Griffero F, Vandegraaff N, Li Y, McGee-Estrada K, Stremlau M, Welikala S, Si Z, Engelman A, Sodroski JVirologyRequirements for capsid-binding and an effector function in TRIMCyp-mediated restriction of HIV-1. Virology. 2006 Aug 01; 351(2):404-19.Virology2006-05-02T00:00:002006Requirements for capsid-binding and an effector function in TRIMCyp-mediated restriction of HIV-1.17258258Raghavendra NK, Engelman AVirologyLEDGF/p75 interferes with the formation of synaptic nucleoprotein complexes that catalyze full-site HIV-1 DNA integration in vitro: implications for the mechanism of viral cDNA integration. Virology. 2007 Mar 30; 360(1):1-5.Virology2007-01-26T00:00:002007LEDGF/p75 interferes with the formation of synaptic nucleoprotein complexes that catalyze full-site HIV-1 DNA integration in vitro: implications for the mechanism of viral cDNA integration.23097450Koh Y, Wu X, Ferris AL, Matreyek KA, Smith SJ, Lee K, KewalRamani VN, Hughes SH, Engelman AJournal of virologyDifferential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration. J Virol. 2013 Jan; 87(1):648-58.J Virol2012-10-24T00:00:002012Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration.Authorship 1035678729276085Zhu Y, Wang X, Forouzmand E, Jeong J, Qiao F, Sowd GA, Engelman AN, Xie X, Hertel KJ, Shi YMolecular cellMolecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation. Mol Cell. 2018 01 04; 69(1):62-74.e4.Mol Cell2017-12-21T00:00:002017Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation.21060108Koh Y, Haim H, Engelman AAntimicrobial agents and chemotherapyIdentification and characterization of persistent intracellular human immunodeficiency virus type 1 integrase strand transfer inhibitor activity. Antimicrob Agents Chemother. 2011 Jan; 55(1):42-9.Antimicrob Agents Chemother2010-11-08T00:00:002010Identification and characterization of persistent intracellular human immunodeficiency virus type 1 integrase strand transfer inhibitor activity.21216426Li X, Krishnan L, Cherepanov P, Engelman AVirologyStructural biology of retroviral DNA integration. Virology. 2011 Mar 15; 411(2):194-205.Virology2011-01-08T00:00:002011Structural biology of retroviral DNA integration.23364444Koh Y, Ballana E, Este J, Engelman AAIDS (London, England)Polymorphic LEDGF/p75 variants support efficient HIV-1 infection ex vivo. AIDS. 2013 Feb 20; 27(4):665-7.AIDS2013-02-20T00:00:002013Polymorphic LEDGF/p75 variants support efficient HIV-1 infection ex vivo.8631811Jenkins TM, Engelman A, Ghirlando R, Craigie RThe Journal of biological chemistryA soluble active mutant of HIV-1 integrase: involvement of both the core and carboxyl-terminal domains in multimerization. J Biol Chem. 1996 Mar 29; 271(13):7712-8.J Biol Chem1996-03-29T00:00:001996A soluble active mutant of HIV-1 integrase: involvement of both the core and carboxyl-terminal domains in multimerization.22421880Engelman A, Cherepanov PNature reviews. MicrobiologyThe structural biology of HIV-1: mechanistic and therapeutic insights. Nat Rev Microbiol. 2012 03 16; 10(4):279-90.Nat Rev Microbiol2012-03-16T00:00:002012The structural biology of HIV-1: mechanistic and therapeutic insights.3265094Engelman A, Rosenberg NCurrent topics in microbiology and immunologyThe Abelson protein is required for initiation and maintenance for transformation in murine pre-B cells. Curr Top Microbiol Immunol. 1988; 141:310-5.Curr Top Microbiol Immunol1988-01-01T00:00:001988The Abelson protein is required for initiation and maintenance for transformation in murine pre-B cells.2825174Engelman A, Rosenberg NProceedings of the National Academy of Sciences of the United States of AmericaIsolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis. Proc Natl Acad Sci U S A. 1987 Nov; 84(22):8021-5.Proc Natl Acad Sci U S A1987-11-01T00:00:001987Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis.1404595Engelman A, Craigie RJournal of virologyIdentification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro. J Virol. 1992 Nov; 66(11):6361-9.J Virol1992-11-01T00:00:001992Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro.