Ion transport across biological membranes plays a crucial role in several physiological and pathological processes. My research has been focused on the study of the transport systems mediating transport of Na and K across the membrane of erythrocytes. My studies have addressed the issue of how these transporters induce cellular dehydration in sickle cell disease and whether we can use the knowledge gained from the study of these systems to develop new therapeutic approaches for sickle cell anemia. This approach is relevant to the pathogenesis and potential therapy of this disease because it is known that dehydration of sickle erythrocytes promotes sickling and may have a major role in the vascular complications of this disease. My clinical laboratory-based research has been focused on the use of hematological parameters to assess the balance between iron availability and erythropoiesis. We have described the appearance of functional iron deficiency in normal subjects treated with recombinant human erythropoietin (r-HuEPO) based on the particular flow cytometric characteristics of erythrocytes and reticulocytes. We have shown the clinical value of reticulocyte parameters in the setting of r-HuEPO use and in the diagnosis of iron deficiency in children.
Brugnara C, Zurakowski D, DiCanzio J, Boyd T, Platt O
Reticulocyte hemoglobin content to diagnose iron deficiency in children. JAMA. 1999 Jun 16; 281(23):2225-30.
Reticulocyte hemoglobin content to diagnose iron deficiency in children.
Wish JB, Aronoff GR, Bacon BR, Brugnara C, Eckardt KU, Ganz T, Macdougall IC, Núñez J, Perahia AJ, Wood JC
Positive Iron Balance in Chronic Kidney Disease: How Much is Too Much and How to Tell? Am J Nephrol. 2018; 47(2):72-83.
Positive Iron Balance in Chronic Kidney Disease: How Much is Too Much and How to Tell?
Stocker JW, De Franceschi L, McNaughton-Smith GA, Corrocher R, Beuzard Y, Brugnara C
ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice. Blood. 2003 Mar 15; 101(6):2412-8.
ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice.
Halperin JA, Brugnara C, Van Ha T, Tosteson DC
Voltage-activated cation permeability in high-potassium but not low-potassium red blood cells. Am J Physiol. 1990 Jun; 258(6 Pt 1):C1169-72.
Voltage-activated cation permeability in high-potassium but not low-potassium red blood cells.
Ca(2+)-activated K+ transport in erythrocytes. Comparison of binding and transport inhibition by scorpion toxins. J Biol Chem. 1993 Apr 25; 268(12):8760-8.
Ca(2+)-activated K+ transport in erythrocytes. Comparison of binding and transport inhibition by scorpion toxins.
Rivera A, Ferreira A, Bertoni D, Romero JR, Brugnara C
Abnormal regulation of Mg2+ transport via Na/Mg exchanger in sickle erythrocytes. Blood. 2005 Jan 01; 105(1):382-6.
Abnormal regulation of Mg2+ transport via Na/Mg exchanger in sickle erythrocytes.
Brugnara C, Kopin AS, Bunn HF, Tosteson DC
Transactions of the Association of American Physicians
Electrolyte composition and equilibrium in hemoglobin CC red blood cells. Trans Assoc Am Physicians. 1984; 97:104-12.
Electrolyte composition and equilibrium in hemoglobin CC red blood cells.
Brugnara C, Armsby CC, Sakamoto M, Rifai N, Alper SL, Platt O
The Journal of pharmacology and experimental therapeutics
Oral administration of clotrimazole and blockade of human erythrocyte Ca(++)-activated K+ channel: the imidazole ring is not required for inhibitory activity. J Pharmacol Exp Ther. 1995 Apr; 273(1):266-72.
Oral administration of clotrimazole and blockade of human erythrocyte Ca(++)-activated K+ channel: the imidazole ring is not required for inhibitory activity.
Rutherford CJ, Schneider TJ, Dempsey H, Kirn DH, Brugnara C, Goldberg MA
Efficacy of different dosing regimens for recombinant human erythropoietin in a simulated perisurgical setting: the importance of iron availability in optimizing response. Am J Med. 1994 Feb; 96(2):139-45.
Efficacy of different dosing regimens for recombinant human erythropoietin in a simulated perisurgical setting: the importance of iron availability in optimizing response.
Degree of agreement in plasma fibrinogen among two functional and one immunonephelometric assays. Am J Clin Pathol. 1997 May; 107(5):527-33.
Degree of agreement in plasma fibrinogen among two functional and one immunonephelometric assays.
Tanphaichitr VS, Sumboonnanonda A, Ideguchi H, Shayakul C, Brugnara C, Takao M, Veerakul G, Alper SL
Novel AE1 mutations in recessive distal renal tubular acidosis. Loss-of-function is rescued by glycophorin A. J Clin Invest. 1998 Dec 15; 102(12):2173-9.
Novel AE1 mutations in recessive distal renal tubular acidosis. Loss-of-function is rescued by glycophorin A.
Gilligan DM, Lozovatsky L, Gwynn B, Brugnara C, Mohandas N, Peters LL
Proceedings of the National Academy of Sciences of the United States of America
Targeted disruption of the beta adducin gene (Add2) causes red blood cell spherocytosis in mice. Proc Natl Acad Sci U S A. 1999 Sep 14; 96(19):10717-22.
Targeted disruption of the beta adducin gene (Add2) causes red blood cell spherocytosis in mice.
Clinical hemorheology and microcirculation
Sickle cell dehydration: Pathophysiology and therapeutic applications. Clin Hemorheol Microcirc. 2018; 68(2-3):187-204.
Sickle cell dehydration: Pathophysiology and therapeutic applications.
Rifai N, Sakamoto M, Law T, Platt O, Mikati M, Armsby CC, Brugnara C
HPLC measurement, blood distribution, and pharmacokinetics of oral clotrimazole, potentially useful antisickling agent. Clin Chem. 1995 Mar; 41(3):387-91.
HPLC measurement, blood distribution, and pharmacokinetics of oral clotrimazole, potentially useful antisickling agent.
Management training for pathology residents. I. Results of a national survey. Am J Clin Pathol. 1994 May; 101(5):559-63.
Management training for pathology residents. I. Results of a national survey.
de Franceschi L, Rouyer-Fessard P, Alper SL, Jouault H, Brugnara C, Beuzard Y
Combination therapy of erythropoietin, hydroxyurea, and clotrimazole in a beta thalassemic mouse: a model for human therapy. Blood. 1996 Feb 01; 87(3):1188-95.
Combination therapy of erythropoietin, hydroxyurea, and clotrimazole in a beta thalassemic mouse: a model for human therapy.
Brugnara C, Gee B, Armsby CC, Kurth S, Sakamoto M, Rifai N, Alper SL, Platt OS
Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease. J Clin Invest. 1996 Mar 01; 97(5):1227-34.
Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease.
Armsby CC, Stuart-Tilley AK, Alper SL, Brugnara C
Resistance to osmotic lysis in BXD-31 mouse erythrocytes: association with upregulated K-Cl cotransport. Am J Physiol. 1996 Mar; 270(3 Pt 1):C866-77.
Resistance to osmotic lysis in BXD-31 mouse erythrocytes: association with upregulated K-Cl cotransport.
Casula S, Shmukler BE, Wilhelm S, Stuart-Tilley AK, Su W, Chernova MN, Brugnara C, Alper SL
A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity. J Biol Chem. 2001 Nov 09; 276(45):41870-8.
A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.
A hematologic "gold standard" for iron-deficient states? Clin Chem. 2002 Jul; 48(7):981-2.
A hematologic "gold standard" for iron-deficient states?
Coffin CM, Hamilton MS, Pysher TJ, Bach P, Ashwood E, Schweiger J, Monahan D, Perry D, Rogers BB, Brugnara C, Rutledge J, Weiss R, Ash O, Hill H, Meikle W, Roberts W, Geaghan S
Pediatric laboratory medicine: current challenges and future opportunities. Am J Clin Pathol. 2002 May; 117(5):683-90.
Pediatric laboratory medicine: current challenges and future opportunities.
Rifai N, Plebani M, Wu A, Brugnara C, Delvin E, Lamb EJ, Ness PM, Wick MR, Berg JP
Full disclosure in industry-sponsored laboratory medicine research studies: statement by the Consortium of Laboratory Medicine Journal Editors. Ann Clin Biochem. 2011 Jan; 48(Pt 1):5-6.
Full disclosure in industry-sponsored laboratory medicine research studies: statement by the Consortium of Laboratory Medicine Journal Editors.
Halperin JA, Nicholson-Weller A, Brugnara C, Tosteson DC
Complement induces a transient increase in membrane permeability in unlysed erythrocytes. J Clin Invest. 1988 Aug; 82(2):594-600.
Complement induces a transient increase in membrane permeability in unlysed erythrocytes.
Inhibition of Ca(2+)-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives. J Clin Invest. 1993 Jul; 92(1):520-6.
Inhibition of Ca(2+)-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives.
[Clinical trials of new therapeutic pharmacology for sickle cell disease]. Sante. 2006 Oct-Dec; 16(4):263-8.
[Clinical trials of new therapeutic pharmacology for sickle cell disease].
Bertin A, Mahaney MC, Cox LA, Rogers J, VandeBerg JL, Brugnara C, Platt OS
Mammalian genome : official journal of the International Mammalian Genome Society
Quantitative trait loci for peripheral blood cell counts: a study in baboons. Mamm Genome. 2007 May; 18(5):361-72.
Quantitative trait loci for peripheral blood cell counts: a study in baboons.
Halperin JA, Brugnara C, Kopin AS, Ingwall J, Tosteson DC
Properties of the Na+-K+ pump in human red cells with increased number of pump sites. J Clin Invest. 1987 Jul; 80(1):128-37.
Properties of the Na+-K+ pump in human red cells with increased number of pump sites.
Full disclosure in industry-sponsored laboratory medicine research studies: statement by the Consortium of Laboratory Medicine Journal Editors. Clin Chem. 2011 Mar; 57(3):359-60.
Goldberg MA, Brugnara C, Dover GJ, Schapira L, Charache S, Bunn HF
Treatment of sickle cell anemia with hydroxyurea and erythropoietin. N Engl J Med. 1990 Aug 09; 323(6):366-72.
Treatment of sickle cell anemia with hydroxyurea and erythropoietin.
Olivieri O, Vitoux D, Galacteros F, Bachir D, Blouquit Y, Beuzard Y, Brugnara C
Hemoglobin variants and activity of the (K+Cl-) cotransport system in human erythrocytes. Blood. 1992 Feb 01; 79(3):793-7.
Hemoglobin variants and activity of the (K+Cl-) cotransport system in human erythrocytes.
Rifai N, Annesley TM, Berg JP, Brugnara C, Delvin E, Lamb EJ, Ness PM, Plebani M, Wick MR, Wu A
An appeal to medical journal editors: the need for a full description of laboratory methods and specimen handling in clinical study reports. Transfusion. 2012 Jun; 52(6):e17-9.
An appeal to medical journal editors: the need for a full description of laboratory methods and specimen handling in clinical study reports.
The Journal of adolescent health : official publication of the Society for Adolescent Medicine
An algorithm using reticulocyte hemoglobin content (CHr) measurement in screening adolescents for iron deficiency. J Adolesc Health. 2005 Jun; 36(6):529.
An algorithm using reticulocyte hemoglobin content (CHr) measurement in screening adolescents for iron deficiency.
Bize I, Güvenç B, Buchbinder G, Brugnara C
Stimulation of human erythrocyte K-Cl cotransport and protein phosphatase type 2A by n-ethylmaleimide: role of intracellular Mg++. J Membr Biol. 2000 Sep 15; 177(2):159-68.
Stimulation of human erythrocyte K-Cl cotransport and protein phosphatase type 2A by n-ethylmaleimide: role of intracellular Mg++.
Brugnara C, De Franceschi L, Bennekou P, Alper SL, Christophersen P
Novel therapies for prevention of erythrocyte dehydration in sickle cell anemia. Drug News Perspect. 2001 May; 14(4):208-20.
Novel therapies for prevention of erythrocyte dehydration in sickle cell anemia.
Shah DI, Takahashi-Makise N, Cooney JD, Li L, Schultz IJ, Pierce EL, Narla A, Seguin A, Hattangadi SM, Medlock AE, Langer NB, Dailey TA, Hurst SN, Faccenda D, Wiwczar JM, Heggers SK, Vogin G, Chen W, Chen C, Campagna DR, Brugnara C, Zhou Y, Ebert BL, Danial NN, Fleming MD, Ward DM, Campanella M, Dailey HA, Kaplan J, Paw BH
Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts. Nature. 2012 Nov 22; 491(7425):608-12.
Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts.
Corrocher R, Ferrari S, Bassi A, Guarini P, Bertinato L, Olivieri O, Licia GM, Ruzzenente O, Brugnara C, De Sandre G
Membrane polyunsaturated fatty acids and lithium-sodium countertransport in human erythrocytes. Life Sci. 1987 Aug 31; 41(9):1171-8.
Membrane polyunsaturated fatty acids and lithium-sodium countertransport in human erythrocytes.
Rifai N, Annesley TM, Berg JP, Brugnara C, Delvin E, Lamb EJ, Ness PM, Plebani M, Wick MR, Wu A, Delanghe J
An appeal to medical journal editors: the need for a full description of laboratory methods and specimen handling in clinical study reports. Clin Chem. 2012 Mar; 58(3):483-5.
Andolfo I, Alper SL, Delaunay J, Auriemma C, Russo R, Asci R, Esposito MR, Sharma AK, Shmukler BE, Brugnara C, De Franceschi L, Iolascon A
Missense mutations in the ABCB6 transporter cause dominant familial pseudohyperkalemia. Am J Hematol. 2013 Jan; 88(1):66-72.
Missense mutations in the ABCB6 transporter cause dominant familial pseudohyperkalemia.
Warady BA, Kausz A, Lerner G, Brewer ED, Chadha V, Brugnara C, Dahl NV, Watkins SL
Iron therapy in the pediatric hemodialysis population. Pediatr Nephrol. 2004 Jun; 19(6):655-61.
Iron therapy in the pediatric hemodialysis population.
Marinkovic D, Zhang X, Yalcin S, Luciano JP, Brugnara C, Huber T, Ghaffari S
Foxo3 is required for the regulation of oxidative stress in erythropoiesis. J Clin Invest. 2007 Aug; 117(8):2133-44.
Foxo3 is required for the regulation of oxidative stress in erythropoiesis.
Hankins JS, Wynn LW, Brugnara C, Hillery CA, Li CS, Wang WC
Phase I study of magnesium pidolate in combination with hydroxycarbamide for children with sickle cell anaemia. Br J Haematol. 2008 Jan; 140(1):80-5.
Phase I study of magnesium pidolate in combination with hydroxycarbamide for children with sickle cell anaemia.
Characteristics of the volume- and chloride-dependent K transport in human erythrocytes homozygous for hemoglobin C. J Membr Biol. 1989 Oct; 111(1):69-81.
Characteristics of the volume- and chloride-dependent K transport in human erythrocytes homozygous for hemoglobin C.
Corrocher R, Bonfanti F, Steinmayr M, Brugnara C, Bertinato L, De Sandre G
[Frequency and sex and age distribution of cardiopathy in arterial hypertension]. Minerva Cardioangiol. 1986 Mar; 34(3):119-25.
[Frequency and sex and age distribution of cardiopathy in arterial hypertension].
Coupry I, Armsby CC, Alper S, Parini A, Brugnara C
Annals of the New York Academy of Sciences
Inhibition of red cell Ca(2+)-activated K+ transport by clotrimazole does not take place via imidazoline binding sites. Ann N Y Acad Sci. 1995 Jul 12; 763:287-9.
Inhibition of red cell Ca(2+)-activated K+ transport by clotrimazole does not take place via imidazoline binding sites.
Brugnara C, Laufer MR, Friedman AJ, Bridges K, Platt O
Reticulocyte hemoglobin content (CHr): early indicator of iron deficiency and response to therapy. Blood. 1994 May 15; 83(10):3100-1.
Reticulocyte hemoglobin content (CHr): early indicator of iron deficiency and response to therapy.
Ilboudo Y, Bartolucci P, Garrett ME, Ashley-Koch A, Telen M, Brugnara C, Galactéros F, Lettre G
A common functional PIEZO1 deletion allele associates with red blood cell density in sickle cell disease patients. Am J Hematol. 2018 11; 93(11):E362-E365.
A common functional PIEZO1 deletion allele associates with red blood cell density in sickle cell disease patients.
Benzaquen LR, Brugnara C, Byers HR, Gatton-Celli S, Halperin JA
Clotrimazole inhibits cell proliferation in vitro and in vivo. Nat Med. 1995 Jun; 1(6):534-40.
Clotrimazole inhibits cell proliferation in vitro and in vivo.
Ballas SK, McCarthy WF, Guo N, Brugnara C, Kling G, Bauserman RL, Waclawiw MA
Early detection of response to hydroxyurea therapy in patients with sickle cell anemia. Hemoglobin. 2010; 34(5):424-9.
Early detection of response to hydroxyurea therapy in patients with sickle cell anemia.
Full-disclosure in industry-sponsored laboratory medicine research studies: Statement by the Consortium of Laboratory Medicine Journal Editors. Am J Hematol. 2011 Mar; 86(3):244.
Full-disclosure in industry-sponsored laboratory medicine research studies: Statement by the Consortium of Laboratory Medicine Journal Editors.
Andolfo I, Russo R, Rosato BE, Manna F, Gambale A, Brugnara C, Iolascon A
Genotype-phenotype correlation and risk stratification in a cohort of 123 hereditary stomatocytosis patients. Am J Hematol. 2018 12; 93(12):1509-1517.
Genotype-phenotype correlation and risk stratification in a cohort of 123 hereditary stomatocytosis patients.
Corrocher R, Brugnara C, Maso R, Taddei G, Mezzelani P, De Sandre G
Multiple arterial stenoses in chronic ergot toxicity. N Engl J Med. 1984 Jan 26; 310(4):261.
Multiple arterial stenoses in chronic ergot toxicity.
Bonfanti F, Pecci R, Nortilli R, Brugnara C, Corrocher R
[Relations between renin activity and vascular complications of arterial hypertension]. Minerva Cardioangiol. 1982 Mar; 30(3):75-80.
[Relations between renin activity and vascular complications of arterial hypertension].
Brugnara C, Armsby CC, De Franceschi L, Crest M, Euclaire MF, Alper SL
Ca(2+)-activated K+ channels of human and rabbit erythrocytes display distinctive patterns of inhibition by venom peptide toxins. J Membr Biol. 1995 Sep; 147(1):71-82.
Ca(2+)-activated K+ channels of human and rabbit erythrocytes display distinctive patterns of inhibition by venom peptide toxins.
The Li+-Na+ exchange and Na+-K+-Cl- cotransport systems in essential hypertension. Hypertension. 1987 Nov; 10(5 Pt 2):I4-10.
The Li+-Na+ exchange and Na+-K+-Cl- cotransport systems in essential hypertension.
Alper SL, Vandorpe DH, Peters LL, Brugnara C
Reduced DIDS-sensitive chloride conductance in Ae1-/- mouse erythrocytes. Blood Cells Mol Dis. 2008 Jul-Aug; 41(1):22-34.
Reduced DIDS-sensitive chloride conductance in Ae1-/- mouse erythrocytes.
Shaker M, Jenkins P, Ullrich C, Brugnara C, Nghiem BT, Bernstein H
An economic analysis of anemia prevention during infancy. J Pediatr. 2009 Jan; 154(1):44-9.
An economic analysis of anemia prevention during infancy.
An appeal to medical journal editors: the need for a full description of laboratory methods and specimen handling in clinical study reports. Clin Biochem. 2012 Feb; 45(3):185-6.
Scandinavian journal of clinical and laboratory investigation
An appeal to medical journal editors: the need for a full description of laboratory methods and specimen handling in clinical study reports. Scand J Clin Lab Invest. 2012 Apr; 72(2):89-91.
An appeal to medical journal editors: the need for a full description of laboratory methods and specimen handling in clinical study reports. Am J Hematol. 2012 Apr; 87(4):347-8.
Canessa M, Brugnara C, Cusi D, Tosteson DC
Modes of operation and variable stoichiometry of the furosemide- sensitive Na and K fluxes in human red cells. J Gen Physiol. 1986 Jan; 87(1):113-42.
Modes of operation and variable stoichiometry of the furosemide- sensitive Na and K fluxes in human red cells.
The regulation of Na-K cotransport system and essential hypertension. Klin Wochenschr. 1985; 63 Suppl 3:52-4.
The regulation of Na-K cotransport system and essential hypertension.
Egan ES, Weekes MP, Kanjee U, Manzo J, Srinivasan A, Lomas-Francis C, Westhoff C, Takahashi J, Tanaka M, Watanabe S, Brugnara C, Gygi SP, Tani Y, Duraisingh MT
Erythrocytes lacking the Langereis blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparum. Commun Biol. 2018; 1:45.
Erythrocytes lacking the Langereis blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparum.
Aune MW, Becker JL, Brugnara C, Canfield W, Dorfman DM, Fiehn W, Fischer G, Fitzpatrick P, Flaming TH, Henriksen HK, Kunicka JE, Lackner KJ, Minchello E, Mullenix PA, Myers M, Petersen A, Ternstrom W, Wilson SJ
Automated flow cytometric analysis of blood cells in cerebrospinal fluid: analytic performance. Am J Clin Pathol. 2004 May; 121(5):690-700.
Automated flow cytometric analysis of blood cells in cerebrospinal fluid: analytic performance.
Brugnara C, Colella GM, Cremins J, Langley RC, Schneider TJ, Rutherford CJ, Goldberg MA
The Journal of laboratory and clinical medicine
Effects of subcutaneous recombinant human erythropoietin in normal subjects: development of decreased reticulocyte hemoglobin content and iron-deficient erythropoiesis. J Lab Clin Med. 1994 May; 123(5):660-7.
Effects of subcutaneous recombinant human erythropoietin in normal subjects: development of decreased reticulocyte hemoglobin content and iron-deficient erythropoiesis.
Inhibition of K transport by divalent cations in sickle erythrocytes. Blood. 1987 Dec; 70(6):1810-5.
Inhibition of K transport by divalent cations in sickle erythrocytes.
Brock TA, Brugnara C, Canessa M, Gimbrone MA
Bradykinin and vasopressin stimulate Na+-K+-Cl- cotransport in cultured endothelial cells. Am J Physiol. 1986 Jun; 250(6 Pt 1):C888-95.
Bradykinin and vasopressin stimulate Na+-K+-Cl- cotransport in cultured endothelial cells.
Browne PV, Shalev O, Kuypers FA, Brugnara C, Solovey A, Mohandas N, Schrier SL, Hebbel RP
Removal of erythrocyte membrane iron in vivo ameliorates the pathobiology of murine thalassemia. J Clin Invest. 1997 Sep 15; 100(6):1459-64.
Removal of erythrocyte membrane iron in vivo ameliorates the pathobiology of murine thalassemia.
Roback MG, Stack AM, Thompson C, Brugnara C, Schwarz HP, Saladino RA
Activated protein C concentrate for the treatment of meningococcal endotoxin shock in rabbits. Shock. 1998 Feb; 9(2):138-42.
Activated protein C concentrate for the treatment of meningococcal endotoxin shock in rabbits.
Cation transport in mouse erythrocytes: role of K(+)-Cl- cotransport in regulatory volume decrease. Am J Physiol. 1995 Apr; 268(4 Pt 1):C894-902.
Cation transport in mouse erythrocytes: role of K(+)-Cl- cotransport in regulatory volume decrease.
Effect of cell age and phenylhydrazine on the cation transport properties of rabbit erythrocytes. J Cell Physiol. 1993 Feb; 154(2):271-80.
Effect of cell age and phenylhydrazine on the cation transport properties of rabbit erythrocytes.
Piva E, Brugnara C, Chiandetti L, Plebani M
Clinical chemistry and laboratory medicine
Automated reticulocyte counting: state of the art and clinical applications in the evaluation of erythropoiesis. Clin Chem Lab Med. 2010 Oct; 48(10):1369-80.
Automated reticulocyte counting: state of the art and clinical applications in the evaluation of erythropoiesis.
Brugnara C, Corrocher R, Foroni L, Steinmayr M, Bonfanti F, De Sandre G
Lithium-sodium countertransport in erythrocytes of normal and hypertensive subjects. Relationship with age and plasma renin activity. Hypertension. 1983 Jul-Aug; 5(4):529-34.
Lithium-sodium countertransport in erythrocytes of normal and hypertensive subjects. Relationship with age and plasma renin activity.
Brugnara C, Hipp MJ, Irving PJ, Lathrop H, Lee PA, Minchello EM, Winkelman J
Automated reticulocyte counting and measurement of reticulocyte cellular indices. Evaluation of the Miles H*3 blood analyzer. Am J Clin Pathol. 1994 Nov; 102(5):623-32.
Automated reticulocyte counting and measurement of reticulocyte cellular indices. Evaluation of the Miles H*3 blood analyzer.
Management training for pathology residents. II. Experience with a focused curriculum. Am J Clin Pathol. 1994 May; 101(5):564-8.
Management training for pathology residents. II. Experience with a focused curriculum.
Jarolim P, Rubin HL, Liu SC, Cho MR, Brabec V, Derick LH, Yi SJ, Saad ST, Alper S, Brugnara C
Duplication of 10 nucleotides in the erythroid band 3 (AE1) gene in a kindred with hereditary spherocytosis and band 3 protein deficiency (band 3PRAGUE). J Clin Invest. 1994 Jan; 93(1):121-30.
Duplication of 10 nucleotides in the erythroid band 3 (AE1) gene in a kindred with hereditary spherocytosis and band 3 protein deficiency (band 3PRAGUE).
Matte A, Recchiuti A, Federti E, Koehl B, Mintz T, El Nemer W, Tharaux PL, Brousse V, Andolfo I, Lamolinara A, Weinberg O, Siciliano A, Norris PC, Riley IR, Iolascon A, Serhan CN, Brugnara C, De Franceschi L
Resolution of sickle cell disease-associated inflammation and tissue damage with 17R-resolvin D1. Blood. 2019 01 17; 133(3):252-265.
Resolution of sickle cell disease-associated inflammation and tissue damage with 17R-resolvin D1.
De Franceschi L, Saadane N, Trudel M, Alper SL, Brugnara C, Beuzard Y
Treatment with oral clotrimazole blocks Ca(2+)-activated K+ transport and reverses erythrocyte dehydration in transgenic SAD mice. A model for therapy of sickle cell disease. J Clin Invest. 1994 Apr; 93(4):1670-6.
Treatment with oral clotrimazole blocks Ca(2+)-activated K+ transport and reverses erythrocyte dehydration in transgenic SAD mice. A model for therapy of sickle cell disease.
Shape oscillations of single blood drops: applications to human blood and sickle cell disease. Sci Rep. 2018 11 14; 8(1):16794.
Shape oscillations of single blood drops: applications to human blood and sickle cell disease.
Journal of pediatric hematology/oncology
Sickle cell disease: from membrane pathophysiology to novel therapies for prevention of erythrocyte dehydration. J Pediatr Hematol Oncol. 2003 Dec; 25(12):927-33.
Sickle cell disease: from membrane pathophysiology to novel therapies for prevention of erythrocyte dehydration.
Mallozzi C, De Franceschi L, Brugnara C, Di Stasi AM
Protein phosphatase 1alpha is tyrosine-phosphorylated and inactivated by peroxynitrite in erythrocytes through the src family kinase fgr. Free Radic Biol Med. 2005 Jun 15; 38(12):1625-36.
Protein phosphatase 1alpha is tyrosine-phosphorylated and inactivated by peroxynitrite in erythrocytes through the src family kinase fgr.
De Franceschi L, Villa-Moruzzi E, Biondani A, Siciliano A, Brugnara C, Alper SL, Lowell CA, Berton G
Pflugers Archiv : European journal of physiology
Regulation of K-Cl cotransport by protein phosphatase 1alpha in mouse erythrocytes. Pflugers Arch. 2006 Mar; 451(6):760-8.
Regulation of K-Cl cotransport by protein phosphatase 1alpha in mouse erythrocytes.
Rifai N, Sakamoto M, Platt O, Brugnara C
A high-performance liquid chromatographic assay for the determination of itraconazole concentration using solid-phase extraction and small sample volume. Ther Drug Monit. 1995 Oct; 17(5):522-5.
A high-performance liquid chromatographic assay for the determination of itraconazole concentration using solid-phase extraction and small sample volume.
Cell volume, K transport, and cell density in human erythrocytes. Am J Physiol. 1987 Mar; 252(3 Pt 1):C269-76.
Cell volume, K transport, and cell density in human erythrocytes.
Rifai N, Plebani M, Wu AH, Brugnara C, Delvin E, Lamb EJ, Ness PM, Wick MR, Berg JP
Full disclosure in industry-sponsored laboratory medicine research studies: Statement by the Consortium of Laboratory Medicine Journal Editors. Clin Biochem. 2011 Feb; 44(2-3):149-50.
Full disclosure in industry-sponsored laboratory medicine research studies: Statement by the Consortium of Laboratory Medicine Journal Editors.
Properties of K+ transport in resealed human erythrocyte ghosts. Am J Physiol. 1988 Sep; 255(3 Pt 1):C346-56.
Properties of K+ transport in resealed human erythrocyte ghosts.
Brugnara C, De Franceschi L, Armsby CC, Saadane N, Trudel M, Beuzard Y, Rittenhouse A, Rifai N, Platt O, Alper SL
A new therapeutic approach for sickle cell disease. Blockade of the red cell Ca(2+)-activated K+ channel by clotrimazole. Ann N Y Acad Sci. 1995 Jul 12; 763:262-71.
A new therapeutic approach for sickle cell disease. Blockade of the red cell Ca(2+)-activated K+ channel by clotrimazole.
Parisotto R, Gore CJ, Emslie KR, Ashenden MJ, Brugnara C, Howe C, Martin DT, Trout GJ, Hahn AG
A novel method utilising markers of altered erythropoiesis for the detection of recombinant human erythropoietin abuse in athletes. Haematologica. 2000 Jun; 85(6):564-72.
A novel method utilising markers of altered erythropoiesis for the detection of recombinant human erythropoietin abuse in athletes.
de Franceschi L, Turrini F, Honczarenko M, Ayi K, Rivera A, Fleming MD, Law T, Mannu F, Kuypers FA, Bast A, van der Vijgh WJ, Brugnara C
In vivo reduction of erythrocyte oxidant stress in a murine model of beta-thalassemia. Haematologica. 2004 Nov; 89(11):1287-98.
In vivo reduction of erythrocyte oxidant stress in a murine model of beta-thalassemia.
Wang W, Brugnara C, Snyder C, Wynn L, Rogers Z, Kalinyak K, Brown C, Qureshi A, Bigelow C, Neumayr L, Smith-Whitley K, Chui DH, Delahunty M, Woolson R, Steinberg M, Telen M, Kesler K
The effects of hydroxycarbamide and magnesium on haemoglobin SC disease: results of the multi-centre CHAMPS trial. Br J Haematol. 2011 Mar; 152(6):771-6.
The effects of hydroxycarbamide and magnesium on haemoglobin SC disease: results of the multi-centre CHAMPS trial.
Bao EL, Lareau CA, Brugnara C, Fulcher IR, Barau C, Moutereau S, Habibi A, Badaoui B, Berkenou J, Bartolucci P, Galactéros F, Platt OS, Mahaney M, Sankaran VG
Heritability of fetal hemoglobin, white cell count, and other clinical traits from a sickle cell disease family cohort. Am J Hematol. 2019 05; 94(5):522-527.
Heritability of fetal hemoglobin, white cell count, and other clinical traits from a sickle cell disease family cohort.
Wu Y, Zeng J, Roscoe BP, Liu P, Yao Q, Lazzarotto CR, Clement K, Cole MA, Luk K, Baricordi C, Shen AH, Ren C, Esrick EB, Manis JP, Dorfman DM, Williams DA, Biffi A, Brugnara C, Biasco L, Brendel C, Pinello L, Tsai SQ, Wolfe SA, Bauer DE
Highly efficient therapeutic gene editing of human hematopoietic stem cells. Nat Med. 2019 May; 25(5):776-783.
Highly efficient therapeutic gene editing of human hematopoietic stem cells.
Gnanasambandam R, Rivera A, Vandorpe DH, Shmukler BE, Brugnara C, Snyder LM, Andolfo I, Iolascon A, Silveira PA, Hamerschlak N, Gottlieb P, Alper SL
Increased Red Cell KCNN4 Activity in Sporadic Hereditary Xerocytosis Associated With Enhanced Single Channel Pressure Sensitivity of PIEZO1 Mutant V598M. Hemasphere. 2018 10; 2(5):e55.
Increased Red Cell KCNN4 Activity in Sporadic Hereditary Xerocytosis Associated With Enhanced Single Channel Pressure Sensitivity of PIEZO1 Mutant V598M.
Harvard T.H. Chan School of Public Health
Ansari Hosseinzadeh V, Brugnara C, Emani S, Khismatullin D, Holt RG
Journal of thrombosis and haemostasis : JTH
Monitoring of blood coagulation with non-contact drop oscillation rheometry. J Thromb Haemost. 2019 08; 17(8):1345-1353.
Monitoring of blood coagulation with non-contact drop oscillation rheometry.
Rivera A, Vandorpe DH, Shmukler BE, Andolfo I, Iolascon A, Archer NM, Shabani E, Auerbach M, Hamerschlak N, Morton J, Wohlgemuth JG, Brugnara C, Snyder LM, Alper SL
American journal of physiology. Cell physiology
Erythrocyte ion content and dehydration modulate maximal Gardos channel activity in KCNN4 V282M/+ hereditary xerocytosis red cells. Am J Physiol Cell Physiol. 2019 08 01; 317(2):C287-C302.
Erythrocyte ion content and dehydration modulate maximal Gardos channel activity in KCNN4 V282M/+ hereditary xerocytosis red cells.
John LaPorte Given Professor of Immunology and Infectious Diseases
Shmukler BE, Rivera A, Bhargava P, Nishimura K, Hsu A, Kim EH, Trudel M, Rust MB, Hubner CA, Brugnara C, Alper SL
Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease. Blood Cells Mol Dis. 2019 11; 79:102346.
Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease.
Matte A, Federti E, Winter M, Koerner A, Harmeier A, Mazer N, Tomka T, Di Paolo ML, De Falco L, Andolfo I, Beneduce E, Iolascon A, Macias-Garcia A, Chen JJ, Janin A, Lebouef C, Turrini F, Brugnara C, De Franceschi L
Bitopertin, a selective oral GLYT1 inhibitor, improves anemia in a mouse model of ß-thalassemia. JCI Insight. 2019 11 14; 4(22).
Bitopertin, a selective oral GLYT1 inhibitor, improves anemia in a mouse model of ß-thalassemia.
Knowledge of Blood Group Decreases von Willebrand Factor Panel Testing in Children. Hemasphere. 2017 12; 1(1):e3.
Knowledge of Blood Group Decreases von Willebrand Factor Panel Testing in Children.
Shmukler BE, Rivera A, Bhargava P, Nishimura K, Kim EH, Hsu A, Wohlgemuth JG, Morton J, Snyder LM, De Franceschi L, Rust MB, Hubner CA, Brugnara C, Alper SL
Genetic disruption of KCC cotransporters in a mouse model of thalassemia intermedia. Blood Cells Mol Dis. 2020 03; 81:102389.
Genetic disruption of KCC cotransporters in a mouse model of thalassemia intermedia.
Corrigendum to "Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease" [Blood Cells Mol. Dis. (2019) start page-end page not yet assigned] https://doi.org/10.1016/j.bcmd.2019.102346. Blood Cells Mol Dis. 2020 Mar; 81:102390.
Corrigendum to "Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease" [Blood Cells Mol. Dis. (2019) start page-end page not yet assigned] https://doi.org/10.1016/j.bcmd.2019.102346.
Malka R, Brugnara C, Cialic R, Higgins JM
Non-Parametric Combined Reference Regions and Prediction of Clinical Risk. Clin Chem. 2020 02 01; 66(2):363-372.
Non-Parametric Combined Reference Regions and Prediction of Clinical Risk.
Archer NM, Forbes PW, Dargie J, Manganella J, Licameli GR, Kenna MA, Brugnara C
Association of Blood Type With Postsurgical Mucosal Bleeding in Pediatric Patients Undergoing Tonsillectomy With or Without Adenoidectomy. JAMA Netw Open. 2020 03 02; 3(3):e201804.
Association of Blood Type With Postsurgical Mucosal Bleeding in Pediatric Patients Undergoing Tonsillectomy With or Without Adenoidectomy.
Staffa SJ, Joerger JD, Henry E, Christensen RD, Brugnara C, Zurakowski D
Pediatric hematology normal ranges derived from pediatric primary care patients. Am J Hematol. 2020 Oct; 95(10):E255-E257.
Pediatric hematology normal ranges derived from pediatric primary care patients.
Ilboudo Y, Garrett ME, Bartolucci P, Brugnara C, Clish CB, Hirschhorn JN, Galactéros F, Ashley-Koch AE, Telen MJ, Lettre G
Potential causal role of l-glutamine in sickle cell disease painful crises: A Mendelian randomization analysis. Blood Cells Mol Dis. 2021 02; 86:102504.
Potential causal role of l-glutamine in sickle cell disease painful crises: A Mendelian randomization analysis.
Ataga KI, Staffa SJ, Brugnara C, Stocker JW
Haemoglobin response to senicapoc in patients with sickle cell disease: a re-analysis of the Phase III trial. Br J Haematol. 2021 03; 192(5):e129-e132.
Haemoglobin response to senicapoc in patients with sickle cell disease: a re-analysis of the Phase III trial.
Clark MA, Kanjee U, Rangel GW, Chery L, Mascarenhas A, Gomes E, Rathod PK, Brugnara C, Ferreira MU, Duraisingh MT
Plasmodium vivax infection compromises reticulocyte stability. Nat Commun. 2021 03 12; 12(1):1629.
Plasmodium vivax infection compromises reticulocyte stability.
Zemmour D, Charbonnier LM, Leon J, Six E, Keles S, Delville M, Benamar M, Baris S, Zuber J, Chen K, Neven B, Garcia-Lloret MI, Ruemmele FM, Brugnara C, Cerf-Bensussan N, Rieux-Laucat F, Cavazzana M, André I, Chatila TA, Mathis D, Benoist C
Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations. Nat Immunol. 2021 05; 22(5):607-619.
Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations.
Matte A, Federti E, Kung C, Kosinski PA, Narayanaswamy R, Russo R, Federico G, Carlomagno F, Desbats MA, Salviati L, Leboeuf C, Valenti MT, Turrini F, Janin A, Yu S, Beneduce E, Ronseaux S, Iatcenko I, Dang L, Ganz T, Jung CL, Iolascon A, Brugnara C, De Franceschi L
The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a ß-thalassemia mouse model. J Clin Invest. 2021 05 17; 131(10).
The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a ß-thalassemia mouse model.
Taher AT, Viprakasit V, Cappellini MD, Kraus D, Cech P, Volz D, Winter E, Nave S, Dukart J, Khwaja O, Koerner A, Hermosilla R, Brugnara C
Haematological effects of oral administration of bitopertin, a glycine transport inhibitor, in patients with non-transfusion-dependent ß-thalassaemia. Br J Haematol. 2021 07; 194(2):474-477.
Haematological effects of oral administration of bitopertin, a glycine transport inhibitor, in patients with non-transfusion-dependent ß-thalassaemia.
Using Reticulocyte Hemoglobin Equivalent as a Marker for Iron Deficiency and Responsiveness to Iron Therapy. Mayo Clin Proc. 2021 06; 96(6):1510-1519.
Using Reticulocyte Hemoglobin Equivalent as a Marker for Iron Deficiency and Responsiveness to Iron Therapy.
Valenti MT, Mattè A, Federti E, Puder M, Anez-Bustillos L, Deiana M, Cheri S, Minoia A, Brugnara C, Di Paolo ML, Dalle Carbonare L, De Franceschi L
Dietary ?-3 Fatty Acid Supplementation Improves Murine Sickle Cell Bone Disease and Reprograms Adipogenesis. Antioxidants (Basel). 2021 May 18; 10(5).
Dietary ?-3 Fatty Acid Supplementation Improves Murine Sickle Cell Bone Disease and Reprograms Adipogenesis.
Vandorpe DH, Shmukler BE, Ilboudo Y, Bhasin S, Thomas B, Rivera A, Wohlgemuth JG, Dlott JS, Snyder LM, Sieff C, Bhasin M, Lettre G, Brugnara C, Alper SL
A Grammastola spatulata mechanotoxin-4 (GsMTx4)-sensitive cation channel mediates increased cation permeability in human hereditary spherocytosis of multiple genetic etiologies. Haematologica. 2021 10 01; 106(10):2759-2762.
A Grammastola spatulata mechanotoxin-4 (GsMTx4)-sensitive cation channel mediates increased cation permeability in human hereditary spherocytosis of multiple genetic etiologies.
Bachar N, Benbassat D, Brailovsky D, Eshel Y, Glück D, Levner D, Levy S, Pecker S, Yurkovsky E, Zait A, Sever C, Kratz A, Brugnara C
An artificial intelligence-assisted diagnostic platform for rapid near-patient hematology. Am J Hematol. 2021 10 01; 96(10):1264-1274.
An artificial intelligence-assisted diagnostic platform for rapid near-patient hematology.
Arze CA, Springer S, Dudas G, Patel S, Bhattacharyya A, Swaminathan H, Brugnara C, Delagrave S, Ong T, Kahvejian A, Echelard Y, Weinstein EG, Hajjar RJ, Andersen KG, Yozwiak NL
Global genome analysis reveals a vast and dynamic anellovirus landscape within the human virome. Cell Host Microbe. 2021 Aug 11; 29(8):1305-1315.e6.
Global genome analysis reveals a vast and dynamic anellovirus landscape within the human virome.
Diagnostics with modern genomics. Am J Hematol. 2021 11 01; 96(11):E447.
Equey T, Sletten C, Dehnes Y, D'Onofrio G, Brugnara C, Baume N, Aikin R
International journal of laboratory hematology
Standardization of reticulocyte counts in the athlete biological passport: A practical update. Int J Lab Hematol. 2022 Feb; 44(1):112-117.
Standardization of reticulocyte counts in the athlete biological passport: A practical update.
Vandorpe DH, Rivera A, Shmukler BE, Wohlgemuth JG, Dlott JS, Snyder LM, Trudel M, Brugnara C, Alper SL
Trpv1 and Trpa1 are not essential for Psickle-like activity in red cells of the SAD mouse model of sickle cell disease. Blood Cells Mol Dis. 2021 12; 92:102619.
Trpv1 and Trpa1 are not essential for Psickle-like activity in red cells of the SAD mouse model of sickle cell disease.
Shmukler BE, Rivera A, Nishimura K, Hsu A, Wohlgemuth JG, Dlott JS, Michael Snyder L, Brugnara C, Alper SL
Erythroid-specific inactivation of Slc12a6/Kcc3 by EpoR promoter-driven Cre expression reduces K-Cl cotransport activity in mouse erythrocytes. Physiol Rep. 2022 03; 10(5):e15186.
Erythroid-specific inactivation of Slc12a6/Kcc3 by EpoR promoter-driven Cre expression reduces K-Cl cotransport activity in mouse erythrocytes.
Vandorpe DH, Rivera A, Ganter M, Dankwa S, Wohlgemuth JG, Dlott JS, Snyder LM, Brugnara C, Duraisingh M, Alper SL
Purinergic signaling is essential for full Psickle activation by hypoxia and by normoxic acid pH in mature human sickle red cells and in vitro-differentiated cultured human sickle reticulocytes. Pflugers Arch. 2022 05; 474(5):553-565.
Purinergic signaling is essential for full Psickle activation by hypoxia and by normoxic acid pH in mature human sickle red cells and in vitro-differentiated cultured human sickle reticulocytes.
Badenhorst CE, Millet GP, Debevec T, Brocherie F, Coates AM, Burr JF, Andersen AB, Bejder J, Gliemann L, Pedlar CR, Brugnara C, Shiffman VJ, Peters CM, Sheel AW, Bruinvels G, Govus AD, Shivgulam ME, Petterson JL, O’Brien MW, Burden RJ, Besson T, Ansdell P, Sánchez-Briones ME
Journal of applied physiology (Bethesda, Md. : 1985)
Commentaries on Viewpoint: Consider iron status when making sex comparisons in human physiology. J Appl Physiol (1985). 2022 03 01; 132(3):703-709.
Commentaries on Viewpoint: Consider iron status when making sex comparisons in human physiology.
The Erythrocyte, a Novel Disease-Mediator for COVID-19 Vasculopathy? JACC Basic Transl Sci. 2022 Mar; 7(3):205-206.
The Erythrocyte, a Novel Disease-Mediator for COVID-19 Vasculopathy?
Rivera A, Nasburg JA, Shim H, Shmukler BE, Kitten J, Wohlgemuth JG, Dlott JS, Snyder LM, Brugnara C, Wulff H, Alper SL
The erythroid K-Cl cotransport inhibitor [(dihydroindenyl)oxy]acetic acid blocks erythroid Ca2+-activated K+ channel KCNN4. Am J Physiol Cell Physiol. 2022 09 01; 323(3):C694-C705.
The erythroid K-Cl cotransport inhibitor [(dihydroindenyl)oxy]acetic acid blocks erythroid Ca2+-activated K+ channel KCNN4.
HbSC disease: A time for progress. Am J Hematol. 2022 11; 97(11):1390-1393.
Pincez T, Lo KS, D'Orengiani APHD, Garrett ME, Brugnara C, Ashley-Koch AE, Telen MJ, Galacteros F, Joly P, Bartolucci P, Lettre G
Variation and impact of polygenic hematologic traits in monogenic sickle cell disease. Haematologica. 2023 03 01; 108(3):870-881.
Variation and impact of polygenic hematologic traits in monogenic sickle cell disease.
Immune Therapies in the Treatment of Multiple Myeloma. Am J Hematol. 2023 Jan 19.
Immune Therapies in the Treatment of Multiple Myeloma.
Immune therapies in the treatment of multiple myeloma. Am J Hematol. 2023 03; 98 Suppl 2:S3.
Immune therapies in the treatment of multiple myeloma.
Mattè A, Kosinski PA, Federti E, Dang L, Recchiuti A, Russo R, Siciliano A, Riccardi V, Janin A, Mucci M, Leboeuf C, Iolascon A, Brugnara C, De Franceschi L
Mitapivat, a pyruvate kinase activator, improves transfusion burden and reduces iron overload in ß-thalassemic mice. Haematologica. 2023 09 01; 108(9):2535-2541.
Mitapivat, a pyruvate kinase activator, improves transfusion burden and reduces iron overload in ß-thalassemic mice.
Federti E, Matte A, Recchiuti A, Garello F, Ghigo A, El Nemer W, Terreno E, Amoresano A, Mattoscio D, Turrini F, Lebouef C, Janin A, Pantaleo A, Russo R, Marin M, Iatcencko I, Riccardi V, Siciliano A, Iolascon A, Brugnara C, De Franceschi L
In Humanized Sickle Cell Mice, Imatinib Protects Against Sickle Cell-Related Injury. Hemasphere. 2023 Mar; 7(3):e848.
In Humanized Sickle Cell Mice, Imatinib Protects Against Sickle Cell-Related Injury.
Matte A, Wilson AB, Gevi F, Federti E, Recchiuti A, Ferri G, Brunati AM, Pagano MA, Russo R, Leboeuf C, Janin A, Timperio AM, Iolascon A, Gremese E, Dang L, Mohandas N, Brugnara C, De Franceschi L
Mitapivat reprograms the RBC metabolome and improves anemia in a mouse model of hereditary spherocytosis. JCI Insight. 2023 10 23; 8(20).
Mitapivat reprograms the RBC metabolome and improves anemia in a mouse model of hereditary spherocytosis.
Mattè A, Federti E, Recchiuti A, Hamza M, Ferri G, Riccardi V, Ceolan J, Passarini A, Mazzi F, Siciliano A, Bhatt DL, Coughlan D, Climax J, Gremese E, Brugnara C, De Franceschi L
Epeleuton, a novel synthetic ?-3 fatty acid, reduces hypoxia/ reperfusion stress in a mouse model of sickle cell disease. Haematologica. 2024 06 01; 109(6):1918-1932.
Epeleuton, a novel synthetic ?-3 fatty acid, reduces hypoxia/ reperfusion stress in a mouse model of sickle cell disease.
Tsai HK, Sabbagh MF, Montesion M, Williams EA, Arbini A, Boué DR, Harris EM, Wachter F, Grimmett L, Place AE, Lucas F, Nardi V, Kim AS, Brugnara C, Degar B, Pollard J, Harris MH, Bledsoe JR
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Acute Promyelocytic Leukemia With Torque Teno Mini Virus::RARA Fusion: An Approach to Screening and Diagnosis. Mod Pathol. 2024 Jul; 37(7):100509.
Acute Promyelocytic Leukemia With Torque Teno Mini Virus::RARA Fusion: An Approach to Screening and Diagnosis.
Mbiandjeu SCT, Siciliano A, Mattè A, Federti E, Perduca M, Melisi D, Andolfo I, Amoresano A, Iolascon A, Valenti MT, Turrini F, Bovi M, Pisani A, Recchiuti A, Mattoscio D, Riccardi V, Dalle Carbonare L, Brugnara C, Mohandas N, De Franceschi L
Nrf2 Plays a Key Role in Erythropoiesis during Aging. Antioxidants (Basel). 2024 Apr 12; 13(4).
Nrf2 Plays a Key Role in Erythropoiesis during Aging.
Hematology Laboratory in the Digital and Automation Age. Clin Lab Med. 2024 Sep; 44(3):xiii-xiv.
Hematology Laboratory in the Digital and Automation Age.
Self-pay laboratory charges for iron deficiency diagnosis in the Boston and New Haven metropolitan areas. Am J Hematol. 2024 Nov; 99(11):2233-2235.
Self-pay laboratory charges for iron deficiency diagnosis in the Boston and New Haven metropolitan areas.
Brugnara C, Adamson J, Auerbach M, Kane R, Macdougall I, Mast A
Iron deficiency: what are the future trends in diagnostics and therapeutics? Clin Chem. 2013 May; 59(5):740-5.
Iron deficiency: what are the future trends in diagnostics and therapeutics?
Andolfo I, Alper SL, De Franceschi L, Auriemma C, Russo R, De Falco L, Vallefuoco F, Esposito MR, Vandorpe DH, Shmukler BE, Narayan R, Montanaro D, D'Armiento M, Vetro A, Limongelli I, Zuffardi O, Glader BE, Schrier SL, Brugnara C, Stewart GW, Delaunay J, Iolascon A
Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1. Blood. 2013 May 09; 121(19):3925-35, S1-12.
Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1.
Rivera A, Zee RY, Alper SL, Peters LL, Brugnara C
Strain-specific variations in cation content and transport in mouse erythrocytes. Physiol Genomics. 2013 May 01; 45(9):343-50.
Strain-specific variations in cation content and transport in mouse erythrocytes.
Li H, Qiang Y, Li X, Brugnara C, Buffet PA, Dao M, Karniadakis GE, Suresh S
Biomechanics of phagocytosis of red blood cells by macrophages in the human spleen. Proc Natl Acad Sci U S A. 2024 Oct 29; 121(44):e2414437121.
Biomechanics of phagocytosis of red blood cells by macrophages in the human spleen.
Federti E, Mattoscio D, Recchiuti A, Matte A, Monti M, Cozzolino F, Iezzi M, Ceci M, Ghigo A, Tolosano E, Siciliano A, Ceolan J, Riccardi V, Gremese E, Brugnara C, De Franceschi L
17(R)-Resolvin D1 protects against sickle cell-related inflammatory cardiomyopathy in humanized mice. Blood. 2025 Apr 24; 145(17):1915-1928.
17(R)-Resolvin D1 protects against sickle cell-related inflammatory cardiomyopathy in humanized mice.
Siciliano A, D'Alessandro A, Matte A, Bisello G, Bertoldi M, Dzieciatkowska M, Argabright A, Pozzetto RH, Riccardi V, Mattarei A, Ongaro A, Ceolan J, Russo R, Rivadeneyra L, Wind-Rotolo M, Iolascon A, Brugnara C, De Franceschi L
Mitapivat metabolically reprograms human ß-thalassemic erythroblasts, increasing their responsiveness to oxidation. Blood Adv. 2025 Jun 10; 9(11):2818-2830.
Mitapivat metabolically reprograms human ß-thalassemic erythroblasts, increasing their responsiveness to oxidation.
Contemporary Topics in Myeloproliferative Neoplasms and Myelodysplastic Syndromes: American Journal of Hematology 100th Volume Anniversary Symposium. Am J Hematol. 2025 Jun; 100 Suppl 4:3-4.
Contemporary Topics in Myeloproliferative Neoplasms and Myelodysplastic Syndromes: American Journal of Hematology 100th Volume Anniversary Symposium.
Shmukler BE, Vandorpe DH, Rivera A, Auerbach M, Brugnara C, Alper SL
Dehydrated stomatocytic anemia due to the heterozygous mutation R2456H in the mechanosensitive cation channel PIEZO1: a case report. Blood Cells Mol Dis. 2014 Jan; 52(1):53-4.
Dehydrated stomatocytic anemia due to the heterozygous mutation R2456H in the mechanosensitive cation channel PIEZO1: a case report.
Franco SS, De Falco L, Ghaffari S, Brugnara C, Sinclair DA, Matte' A, Iolascon A, Mohandas N, Bertoldi M, An X, Siciliano A, Rimmelé P, Cappellini MD, Michan S, Zoratti E, Anne J, De Franceschi L
Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice. Haematologica. 2014 Feb; 99(2):267-75.
Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice.
Darbari DS, Nouraie M, Taylor JG, Brugnara C, Castro O, Ballas SK
Alpha-thalassaemia and response to hydroxyurea in sickle cell anaemia. Eur J Haematol. 2014 Apr; 92(4):341-5.
Alpha-thalassaemia and response to hydroxyurea in sickle cell anaemia.
Conway AJ, Rosanwo TO, Williamson TE, Landry S, Kinney MA, Clark MA, Vo LT, Rowe RG, Marion W, Zhang Y, Mullin NK, Shi M, Archer NM, Heeney MM, Schlaeger TM, Bauer DE, Duraisingh MT, Brugnara C, North TE, Daley GQ
A xeno-free red blood cell differentiation formula models sickle cell disease from somatically sourced patient iPSCs. Exp Hematol. 2025 Dec; 152:105264.
A xeno-free red blood cell differentiation formula models sickle cell disease from somatically sourced patient iPSCs.
Rimmelé P, Bigarella CL, Liang R, Izac B, Dieguez-Gonzalez R, Barbet G, Donovan M, Brugnara C, Blander JM, Sinclair DA, Ghaffari S
Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells. Stem Cell Reports. 2014 Jul 08; 3(1):44-59.
Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells.
Bhaduri B, Kandel M, Brugnara C, Tangella K, Popescu G
Optical assay of erythrocyte function in banked blood. Sci Rep. 2014 Sep 05; 4:6211.
Optical assay of erythrocyte function in banked blood.
Zhang X, Campreciós G, Rimmelé P, Liang R, Yalcin S, Mungamuri SK, Barminko J, D'Escamard V, Baron MH, Brugnara C, Papatsenko D, Rivella S, Ghaffari S
FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis. Am J Hematol. 2014 Oct; 89(10):954-63.
FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis.
Kumar AA, Patton MR, Hennek JW, Lee SY, D'Alesio-Spina G, Yang X, Kanter J, Shevkoplyas SS, Brugnara C, Whitesides GM
Density-based separation in multiphase systems provides a simple method to identify sickle cell disease. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):14864-9.
Density-based separation in multiphase systems provides a simple method to identify sickle cell disease.
Archer NM, Shmukler BE, Andolfo I, Vandorpe DH, Gnanasambandam R, Higgins JM, Rivera A, Fleming MD, Sachs F, Gottlieb PA, Iolascon A, Brugnara C, Alper SL, Nathan DG
Hereditary xerocytosis revisited. Am J Hematol. 2014 Dec; 89(12):1142-6.
Kumar AA, Chunda-Liyoka C, Hennek JW, Mantina H, Lee SY, Patton MR, Sambo P, Sinyangwe S, Kankasa C, Chintu C, Brugnara C, Stossel TP, Whitesides GM
Evaluation of a density-based rapid diagnostic test for sickle cell disease in a clinical setting in Zambia. PLoS One. 2014; 9(12):e114540.
Evaluation of a density-based rapid diagnostic test for sickle cell disease in a clinical setting in Zambia.
American Journal of Hematology, getting ready for the 40th birthday in 2016. Am J Hematol. 2015 Jan; 90(1):1.
American Journal of Hematology, getting ready for the 40th birthday in 2016.
Sharma S, Brugnara C, Betensky RA, Waikar SS
Clinical journal of the American Society of Nephrology : CJASN
Reductions in red blood cell 2,3-diphosphoglycerate concentration during continuous renal replacment therapy. Clin J Am Soc Nephrol. 2015 Jan 07; 10(1):74-9.
Reductions in red blood cell 2,3-diphosphoglycerate concentration during continuous renal replacment therapy.
Egan ES, Jiang RH, Moechtar MA, Barteneva NS, Weekes MP, Nobre LV, Gygi SP, Paulo JA, Frantzreb C, Tani Y, Takahashi J, Watanabe S, Goldberg J, Paul AS, Brugnara C, Root DE, Wiegand RC, Doench JG, Duraisingh MT
Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion. Science. 2015 May 08; 348(6235):711-4.
Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion.
Piva E, Brugnara C, Spolaore F, Plebani M
Clinical utility of reticulocyte parameters. Clin Lab Med. 2015 Mar; 35(1):133-63.
Clinical utility of reticulocyte parameters.
Automated hematology analyzers: state of the art. Clin Lab Med. 2015 Mar; 35(1):xiii-xiv.
Automated hematology analyzers: state of the art.
Kalish BT, Matte A, Andolfo I, Iolascon A, Weinberg O, Ghigo A, Cimino J, Siciliano A, Hirsch E, Federti E, Puder M, Brugnara C, De Franceschi L
Dietary ?-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease. Haematologica. 2015 Jul; 100(7):870-80.
Dietary ?-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease.
Critical reviews in clinical laboratory sciences
Diagnosis of iron-deficient states. Crit Rev Clin Lab Sci. 2015; 52(5):256-72.
Boscolo E, Limaye N, Huang L, Kang KT, Soblet J, Uebelhoer M, Mendola A, Natynki M, Seront E, Dupont S, Hammer J, Legrand C, Brugnara C, Eklund L, Vikkula M, Bischoff J, Boon LM
Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects. J Clin Invest. 2015 Sep; 125(9):3491-504.
Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects.
Andolfo I, Russo R, Manna F, Shmukler BE, Gambale A, Vitiello G, De Rosa G, Brugnara C, Alper SL, Snyder LM, Iolascon A
Novel Gardos channel mutations linked to dehydrated hereditary stomatocytosis (xerocytosis). Am J Hematol. 2015 Oct; 90(10):921-6.
Novel Gardos channel mutations linked to dehydrated hereditary stomatocytosis (xerocytosis).
Archer NM, Samnaliev M, Grace R, Brugnara C
The utility of the DDAVP challenge test in children with low von Willebrand factor. Br J Haematol. 2015 Sep; 170(6):884-6.
The utility of the DDAVP challenge test in children with low von Willebrand factor.
2015 Clinical trials update in sickle cell anemia. Am J Hematol. 2015 Oct; 90(10):934-50.
2015 Clinical trials update in sickle cell anemia.
Tubman VN, Mejia P, Shmukler BE, Bei AK, Alper SL, Mitchell JR, Brugnara C, Duraisingh MT
The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity. Antimicrob Agents Chemother. 2016 01; 60(1):613-6.
The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity.
The American Journal of Hematology turns 40. Am J Hematol. 2016 Jan; 91(1):4.
The American Journal of Hematology turns 40.
Giani FC, Fiorini C, Wakabayashi A, Ludwig LS, Salem RM, Jobaliya CD, Regan SN, Ulirsch JC, Liang G, Steinberg-Shemer O, Guo MH, Esko T, Tong W, Brugnara C, Hirschhorn JN, Weiss MJ, Zon LI, Chou ST, French DL, Musunuru K, Sankaran VG
Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells. Cell Stem Cell. 2016 Jan 07; 18(1):73-78.
Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells.
Clinical Applications of Automated Reticulocyte Indices. Hematology. 1998; 3(2):165-76.
Clinical Applications of Automated Reticulocyte Indices.
Andolfo I, Russo R, Manna F, De Rosa G, Gambale A, Zouwail S, Detta N, Pardo CL, Alper SL, Brugnara C, Sharma AK, De Franceschi L, Iolascon A
Functional characterization of novel ABCB6 mutations and their clinical implications in familial pseudohyperkalemia. Haematologica. 2016 08; 101(8):909-17.
Functional characterization of novel ABCB6 mutations and their clinical implications in familial pseudohyperkalemia.
ABNORMAL HEMOGLOBINS, CATIONS, AND VOLUME IN RED CELLS
Genetic Determinants of Erythrocyte Hydration
Hennek JW, Kumar AA, Wiltschko AB, Patton MR, Lee SY, Brugnara C, Adams RP, Whitesides GM
Diagnosis of iron deficiency anemia using density-based fractionation of red blood cells. Lab Chip. 2016 10 05; 16(20):3929-3939.
Diagnosis of iron deficiency anemia using density-based fractionation of red blood cells.
De Franceschi L, Beuzard Y, Jouault H, Brugnara C
Modulation of erythrocyte potassium chloride cotransport, potassium content, and density by dietary magnesium intake in transgenic SAD mouse. Blood. 1996 Oct 01; 88(7):2738-44.
Modulation of erythrocyte potassium chloride cotransport, potassium content, and density by dietary magnesium intake in transgenic SAD mouse.
Use of recombinant human erythropoietin outside the setting of uremia. Blood. 1997 Jun 15; 89(12):4248-67.
Use of recombinant human erythropoietin outside the setting of uremia.
Dietary magnesium supplementation ameliorates anemia in a mouse model of beta-thalassemia. Blood. 1997 Aug 01; 90(3):1283-90.
Dietary magnesium supplementation ameliorates anemia in a mouse model of beta-thalassemia.
Hansen A, Whitelaw A, Lapp C, Brugnara C
Cerebrospinal fluid plasminogen activator inhibitor-1: a prognostic factor in posthaemorrhagic hydrocephalus. Acta Paediatr. 1997 Sep; 86(9):995-8.
Cerebrospinal fluid plasminogen activator inhibitor-1: a prognostic factor in posthaemorrhagic hydrocephalus.
[Physiopathology of erythrocyte membrane transport]. Haematologica. 1991 Jun; 76 Suppl 3:191-8.
[Physiopathology of erythrocyte membrane transport].
Iron deficiency and erythropoiesis: new diagnostic approaches. Clin Chem. 2003 Oct; 49(10):1573-8.
Iron deficiency and erythropoiesis: new diagnostic approaches.
Mahaney MC, Brugnara C, Lease LR, Platt OS
Genetic influences on peripheral blood cell counts: a study in baboons. Blood. 2005 Aug 15; 106(4):1210-4.
Genetic influences on peripheral blood cell counts: a study in baboons.
Erythropoietin, iron, and erythropoiesis. Blood. 2000 Aug 01; 96(3):823-33.
Erythropoietin, iron, and erythropoiesis.
Developing treatment for sickle cell disease. Expert Opin Investig Drugs. 2002 May; 11(5):645-59.
Developing treatment for sickle cell disease.
Cellular effects of hydroxyurea in Hb SC disease. Br J Haematol. 1997 Sep; 98(4):838-44.
Cellular effects of hydroxyurea in Hb SC disease.
Murad KL, Mahany KL, Brugnara C, Kuypers FA, Eaton JW, Scott MD
Structural and functional consequences of antigenic modulation of red blood cells with methoxypoly(ethylene glycol). Blood. 1999 Mar 15; 93(6):2121-7.
Structural and functional consequences of antigenic modulation of red blood cells with methoxypoly(ethylene glycol).
Diagnosis of iron-deficient states. Crit Rev Clin Lab Sci. 2015 Aug 14; 1-17.
Endothelins activate Ca(2+)-gated K(+) channels via endothelin B receptors in CD-1 mouse erythrocytes. Am J Physiol. 1999 10; 277(4):C746-54.
Endothelins activate Ca(2+)-gated K(+) channels via endothelin B receptors in CD-1 mouse erythrocytes.
Su W, Shmukler BE, Chernova MN, Stuart-Tilley AK, de Franceschi L, Brugnara C, Alper SL
Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation. Am J Physiol. 1999 11; 277(5):C899-912.
Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation.
De Franceschi L, Brugnara C, Rouyer-Fessard P, Jouault H, Beuzard Y
Formation of dense erythrocytes in SAD mice exposed to chronic hypoxia: evaluation of different therapeutic regimens and of a combination of oral clotrimazole and magnesium therapies. Blood. 1999 Dec 15; 94(12):4307-13.
Formation of dense erythrocytes in SAD mice exposed to chronic hypoxia: evaluation of different therapeutic regimens and of a combination of oral clotrimazole and magnesium therapies.
Iyer R, Baliga R, Nagel RL, Brugnara C, Kirchner K, Hogan S, Steinberg MH
Maximum urine concentrating ability in children with Hb SC disease: effects of hydroxyurea. Am J Hematol. 2000 May; 64(1):47-52.
Maximum urine concentrating ability in children with Hb SC disease: effects of hydroxyurea.
De Franceschi L, Bachir D, Galacteros F, Tchernia G, Cynober T, Alper S, Platt O, Beuzard Y, Brugnara C
Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell disease. J Clin Invest. 1997 Oct 01; 100(7):1847-52.
Oral magnesium supplements reduce erythrocyte dehydration in patients with sickle cell disease.
Canver MC, Lessard S, Pinello L, Wu Y, Ilboudo Y, Stern EN, Needleman AJ, Galactéros F, Brugnara C, Kutlar A, McKenzie C, Reid M, Chen DD, Das PP, A Cole M, Zeng J, Kurita R, Nakamura Y, Yuan GC, Lettre G, Bauer DE, Orkin SH
Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci. Nat Genet. 2017 Apr; 49(4):625-634.
Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci.
Reticulocyte cellular indices: a new approach in the diagnosis of anemias and monitoring of erythropoietic function. Crit Rev Clin Lab Sci. 2000 Apr; 37(2):93-130.
Reticulocyte cellular indices: a new approach in the diagnosis of anemias and monitoring of erythropoietic function.
Rufo PA, Jiang L, Moe SJ, Brugnara C, Alper SL, Lencer WI
The antifungal antibiotic, clotrimazole, inhibits Cl- secretion by polarized monolayers of human colonic epithelial cells. J Clin Invest. 1996 Nov 01; 98(9):2066-75.
The antifungal antibiotic, clotrimazole, inhibits Cl- secretion by polarized monolayers of human colonic epithelial cells.
Erythrocyte membrane transport physiology. Curr Opin Hematol. 1997 Mar; 4(2):122-7.
Erythrocyte membrane transport physiology.
Brugnara C, Zelmanovic D, Sorette M, Ballas SK, Platt O
Reticulocyte hemoglobin: an integrated parameter for evaluation of erythropoietic activity. Am J Clin Pathol. 1997 Aug; 108(2):133-42.
Reticulocyte hemoglobin: an integrated parameter for evaluation of erythropoietic activity.
De Franceschi L, Cappellini MD, Graziadei G, Manzato F, Olivieri O, Corrocher R, Fiorelli G, Beuzard Y, Brugnara C
The effect of dietary magnesium supplementation on the cellular abnormalities of erythrocytes in patients with beta thalassemia intermedia. Haematologica. 1998 Feb; 83(2):118-25.
The effect of dietary magnesium supplementation on the cellular abnormalities of erythrocytes in patients with beta thalassemia intermedia.
Socolovsky M, Fallon AE, Wang S, Brugnara C, Lodish HF
Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction. Cell. 1999 Jul 23; 98(2):181-91.
Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction.
Rivera A, Vandorpe DH, Shmukler BE, Gallagher DR, Fikry CC, Kuypers FA, Brugnara C, Snyder LM, Alper SL
Erythrocytes from hereditary xerocytosis patients heterozygous for KCNN4 V282M exhibit increased spontaneous Gardos channel-like activity inhibited by senicapoc. Am J Hematol. 2017 06; 92(6):E108-E110.
Erythrocytes from hereditary xerocytosis patients heterozygous for KCNN4 V282M exhibit increased spontaneous Gardos channel-like activity inhibited by senicapoc.
Holm TM, Braun A, Trigatti BL, Brugnara C, Sakamoto M, Krieger M, Andrews NC
Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI. Blood. 2002 Mar 01; 99(5):1817-24.
Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI.
Reinterpretation of the RACTK1 K+ channel. Am J Physiol. 1997 Jan; 272(1 Pt 1):C350-4.
Reinterpretation of the RACTK1 K+ channel.
Rufo PA, Merlin D, Riegler M, Ferguson-Maltzman MH, Dickinson BL, Brugnara C, Alper SL, Lencer WI
The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera. J Clin Invest. 1997 Dec 15; 100(12):3111-20.
The antifungal antibiotic, clotrimazole, inhibits chloride secretion by human intestinal T84 cells via blockade of distinct basolateral K+ conductances. Demonstration of efficacy in intact rabbit colon and in an in vivo mouse model of cholera.
Danise P, Amendola G, Nobili B, Perrotta S, Miraglia Del Giudice E, Matarese SM, Iolascon A, Brugnara C
Flow-cytometric analysis of erythrocytes and reticulocytes in congenital dyserythropoietic anaemia type II (CDA II): value in differential diagnosis with hereditary spherocytosis. Clin Lab Haematol. 2001 Feb; 23(1):7-13.
Flow-cytometric analysis of erythrocytes and reticulocytes in congenital dyserythropoietic anaemia type II (CDA II): value in differential diagnosis with hereditary spherocytosis.
Socolovsky M, Nam H, Fleming MD, Haase VH, Brugnara C, Lodish HF
Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. Blood. 2001 Dec 01; 98(12):3261-73.
Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts.
de Franceschi L, Malpeli G, Scarpa A, Janin A, Muchitsch EM, Roncada P, Leboeuf C, Corrocher R, Beuzard Y, Brugnara C
American journal of physiology. Lung cellular and molecular physiology
Protective effects of S-nitrosoalbumin on lung injury induced by hypoxia-reoxygenation in mouse model of sickle cell disease. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 291(3):L457-65.
Protective effects of S-nitrosoalbumin on lung injury induced by hypoxia-reoxygenation in mouse model of sickle cell disease.
Pysher TJ, Bach PR, Geaghan SM, Hamilton MS, Laposata M, Lockitch G, Brugnara C, Coffin CM, Pasquali M, Rinaldo P, Roberts WL, Rutledge JC, Ashwood ER, Blaylock RC, Campos JM, Goldsmith B, Jones PM, Lim M, Meikle AW, Perkins SL, Perry DA, Petti CA, Rogers BB, Steele PE, Weiss RL, Woods G
Archives of pathology & laboratory medicine
Teaching pediatric laboratory medicine to pathology residents. Arch Pathol Lab Med. 2006 Jul; 130(7):1031-8.
Teaching pediatric laboratory medicine to pathology residents.
Rittenhouse AR, Vandorpe DH, Brugnara C, Alper SL
The antifungal imidazole clotrimazole and its major in vivo metabolite are potent blockers of the calcium-activated potassium channel in murine erythroleukemia cells. J Membr Biol. 1997 May 15; 157(2):177-91.
The antifungal imidazole clotrimazole and its major in vivo metabolite are potent blockers of the calcium-activated potassium channel in murine erythroleukemia cells.
Vandorpe DH, Shmukler BE, Jiang L, Lim B, Maylie J, Adelman JP, de Franceschi L, Cappellini MD, Brugnara C, Alper SL
cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation. J Biol Chem. 1998 Aug 21; 273(34):21542-53.
cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation.
de Franceschi L, Shalev O, Piga A, Collell M, Olivieri O, Corrocher R, Hebbel RP, Brugnara C
Deferiprone therapy in homozygous human beta-thalassemia removes erythrocyte membrane free iron and reduces KCl cotransport activity. J Lab Clin Med. 1999 Jan; 133(1):64-9.
Deferiprone therapy in homozygous human beta-thalassemia removes erythrocyte membrane free iron and reduces KCl cotransport activity.
Peters LL, Shivdasani RA, Liu SC, Hanspal M, John KM, Gonzalez JM, Brugnara C, Gwynn B, Mohandas N, Alper SL, Orkin SH, Lux SE
Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton. Cell. 1996 Sep 20; 86(6):917-27.
Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton.
De Franceschi L, Bachir D, Galacteros F, Tchernia G, Cynober T, Neuberg D, Beuzard Y, Brugnara C
Oral magnesium pidolate: effects of long-term administration in patients with sickle cell disease. Br J Haematol. 2000 Feb; 108(2):284-9.
Oral magnesium pidolate: effects of long-term administration in patients with sickle cell disease.
De Franceschi L, Rivera A, Fleming MD, Honczarenko M, Peters LL, Gascard P, Mohandas N, Brugnara C
Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis. Blood. 2005 Aug 15; 106(4):1454-9.
Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis.
Therapeutic strategies for prevention of sickle cell dehydration. Blood Cells Mol Dis. 2001 Jan-Feb; 27(1):71-80.
Therapeutic strategies for prevention of sickle cell dehydration.
Goldberg MA, Brugnara C, Dover GJ, Schapira L, Lacroix L, Bunn HF
Hydroxyurea and erythropoietin therapy in sickle cell anemia. Semin Oncol. 1992 Jun; 19(3 Suppl 9):74-81.
Hydroxyurea and erythropoietin therapy in sickle cell anemia.
Bennekou P, de Franceschi L, Pedersen O, Lian L, Asakura T, Evans G, Brugnara C, Christophersen P
Treatment with NS3623, a novel Cl-conductance blocker, ameliorates erythrocyte dehydration in transgenic SAD mice: a possible new therapeutic approach for sickle cell disease. Blood. 2001 Mar 01; 97(5):1451-7.
Treatment with NS3623, a novel Cl-conductance blocker, ameliorates erythrocyte dehydration in transgenic SAD mice: a possible new therapeutic approach for sickle cell disease.
Erythrocyte-active agents and treatment of sickle cell disease. Semin Hematol. 2001 Oct; 38(4):324-32.
Erythrocyte-active agents and treatment of sickle cell disease.
Full-disclosure in industry-sponsored laboratory medicine research studies: statement by the Consortium of Laboratory Medicine Journal Editors. Scand J Clin Lab Invest. 2011 May; 71(3):177-8.
Full-disclosure in industry-sponsored laboratory medicine research studies: statement by the Consortium of Laboratory Medicine Journal Editors.
Stewart AK, Kedar PS, Shmukler BE, Vandorpe DH, Hsu A, Glader B, Rivera A, Brugnara C, Alper SL
Functional characterization and modified rescue of novel AE1 mutation R730C associated with overhydrated cation leak stomatocytosis. Am J Physiol Cell Physiol. 2011 May; 300(5):C1034-46.
Functional characterization and modified rescue of novel AE1 mutation R730C associated with overhydrated cation leak stomatocytosis.
Clinica chimica acta; international journal of clinical chemistry
An appeal to medical journal editors: the need for a full description of laboratory methods and specimen handling in clinical study reports. Clin Chim Acta. 2012 Apr 11; 413(7-8):653-5.
Hydroxyurea and sickle cell disease: a chance for every patient. JAMA. 2003 Apr 02; 289(13):1692-4.
Hydroxyurea and sickle cell disease: a chance for every patient.
Madore F, Lowrie EG, Brugnara C, Lew NL, Lazarus JM, Bridges K, Owen WF
Journal of the American Society of Nephrology : JASN
Anemia in hemodialysis patients: variables affecting this outcome predictor. J Am Soc Nephrol. 1997 Dec; 8(12):1921-9.
Anemia in hemodialysis patients: variables affecting this outcome predictor.
Bridges KR, Barabino GD, Brugnara C, Cho MR, Christoph GW, Dover G, Ewenstein BM, Golan DE, Guttmann CR, Hofrichter J, Mulkern RV, Zhang B, Eaton WA
A multiparameter analysis of sickle erythrocytes in patients undergoing hydroxyurea therapy. Blood. 1996 Dec 15; 88(12):4701-10.
A multiparameter analysis of sickle erythrocytes in patients undergoing hydroxyurea therapy.
Peters LL, Jindel HK, Gwynn B, Korsgren C, John KM, Lux SE, Mohandas N, Cohen CM, Cho MR, Golan DE, Brugnara C
Mild spherocytosis and altered red cell ion transport in protein 4. 2-null mice. J Clin Invest. 1999 Jun; 103(11):1527-37.
Mild spherocytosis and altered red cell ion transport in protein 4. 2-null mice.
Humbert PO, Rogers C, Ganiatsas S, Landsberg RL, Trimarchi JM, Dandapani S, Brugnara C, Erdman S, Schrenzel M, Bronson RT, Lees JA
E2F4 is essential for normal erythrocyte maturation and neonatal viability. Mol Cell. 2000 Aug; 6(2):281-91.
E2F4 is essential for normal erythrocyte maturation and neonatal viability.
Erythrocyte dehydration in pathophysiology and treatment of sickle cell disease. Curr Opin Hematol. 1995 Mar; 2(2):132-8.
Erythrocyte dehydration in pathophysiology and treatment of sickle cell disease.
Jarolim P, Shayakul C, Prabakaran D, Jiang L, Stuart-Tilley A, Rubin HL, Simova S, Zavadil J, Herrin JT, Brouillette J, Somers MJ, Seemanova E, Brugnara C, Guay-Woodford LM, Alper SL
Autosomal dominant distal renal tubular acidosis is associated in three families with heterozygosity for the R589H mutation in the AE1 (band 3) Cl-/HCO3- exchanger. J Biol Chem. 1998 Mar 13; 273(11):6380-8.
Autosomal dominant distal renal tubular acidosis is associated in three families with heterozygosity for the R589H mutation in the AE1 (band 3) Cl-/HCO3- exchanger.
International journal of clinical & laboratory research
Use of reticulocyte cellular indices in the diagnosis and treatment of hematological disorders. Int J Clin Lab Res. 1998; 28(1):1-11.
Use of reticulocyte cellular indices in the diagnosis and treatment of hematological disorders.
The effect of hemoglobin A and S on the volume- and pH-dependence of K-Cl cotransport in human erythrocyte ghosts. J Membr Biol. 1999 Feb 01; 167(3):233-40.
The effect of hemoglobin A and S on the volume- and pH-dependence of K-Cl cotransport in human erythrocyte ghosts.
Bize I, Güvenç B, Robb A, Buchbinder G, Brugnara C
Serine/threonine protein phosphatases and regulation of K-Cl cotransport in human erythrocytes. Am J Physiol. 1999 11; 277(5):C926-36.
Serine/threonine protein phosphatases and regulation of K-Cl cotransport in human erythrocytes.
Peters LL, Zhang W, Lambert AJ, Brugnara C, Churchill GA, Platt OS
Quantitative trait loci for baseline white blood cell count, platelet count, and mean platelet volume. Mamm Genome. 2005 Oct; 16(10):749-63.
Quantitative trait loci for baseline white blood cell count, platelet count, and mean platelet volume.
Acid pH induces formation of dense cells in sickle erythrocytes. Blood. 1989 Jul; 74(1):487-95.
Acid pH induces formation of dense cells in sickle erythrocytes.
Abdulmalik O, Safo MK, Chen Q, Yang J, Brugnara C, Ohene-Frempong K, Abraham DJ, Asakura T
5-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells. Br J Haematol. 2005 Feb; 128(4):552-61.
5-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells.
Stewart AK, Shmukler BE, Vandorpe DH, Rivera A, Heneghan JF, Li X, Hsu A, Karpatkin M, O'Neill AF, Bauer DE, Heeney MM, John K, Kuypers FA, Gallagher PG, Lux SE, Brugnara C, Westhoff CM, Alper SL
Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S. Am J Physiol Cell Physiol. 2011 Dec; 301(6):C1325-43.
Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S.
Ullrich C, Wu A, Armsby C, Rieber S, Wingerter S, Brugnara C, Shapiro D, Bernstein H
Screening healthy infants for iron deficiency using reticulocyte hemoglobin content. JAMA. 2005 Aug 24; 294(8):924-30.
Screening healthy infants for iron deficiency using reticulocyte hemoglobin content.
Ilboudo Y, Bartolucci P, Rivera A, Sedzro JC, Beaudoin M, Trudel M, Alper SL, Brugnara C, Galactéros F, Lettre G
Genome-wide association study of erythrocyte density in sickle cell disease patients. Blood Cells Mol Dis. 2017 06; 65:60-65.
Genome-wide association study of erythrocyte density in sickle cell disease patients.
Peters LL, Lambert AJ, Zhang W, Churchill GA, Brugnara C, Platt OS
Quantitative trait loci for baseline erythroid traits. Mamm Genome. 2006 Apr; 17(4):298-309.
Quantitative trait loci for baseline erythroid traits.
Brownlie A, Donovan A, Pratt SJ, Paw BH, Oates AC, Brugnara C, Witkowska HE, Sassa S, Zon LI
Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia. Nat Genet. 1998 Nov; 20(3):244-50.
Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia.
Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, Paw BH, Drejer A, Barut B, Zapata A, Law TC, Brugnara C, Lux SE, Pinkus GS, Pinkus JL, Kingsley PD, Palis J, Fleming MD, Andrews NC, Zon LI
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000 Feb 17; 403(6771):776-81.
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter.
De Franceschi L, Fattovich G, Turrini F, Ayi K, Brugnara C, Manzato F, Noventa F, Stanzial AM, Solero P, Corrocher R
Hemolytic anemia induced by ribavirin therapy in patients with chronic hepatitis C virus infection: role of membrane oxidative damage. Hepatology. 2000 Apr; 31(4):997-1004.
Hemolytic anemia induced by ribavirin therapy in patients with chronic hepatitis C virus infection: role of membrane oxidative damage.
Effect of irradiation on red cell cation content and transport. Transfusion. 1992 Mar-Apr; 32(3):246-52.
Effect of irradiation on red cell cation content and transport.
Vandorpe DH, Xu C, Shmukler BE, Otterbein LE, Trudel M, Sachs F, Gottlieb PA, Brugnara C, Alper SL
Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes. PLoS One. 2010 Jan 15; 5(1):e8732.
Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes.
Bartolucci P, Brugnara C, Teixeira-Pinto A, Pissard S, Moradkhani K, Jouault H, Galacteros F
Erythrocyte density in sickle cell syndromes is associated with specific clinical manifestations and hemolysis. Blood. 2012 Oct 11; 120(15):3136-41.
Erythrocyte density in sickle cell syndromes is associated with specific clinical manifestations and hemolysis.
An immunoassay for human serum hepcidin at last: Ganz klar? Blood. 2008 Nov 15; 112(10):3922-3.
An immunoassay for human serum hepcidin at last: Ganz klar?
Peters LL, Shavit JA, Lambert AJ, Tsaih SW, Li Q, Su Z, Leduc MS, Paigen B, Churchill GA, Ginsburg D, Brugnara C
Sequence variation at multiple loci influences red cell hemoglobin concentration. Blood. 2010 Dec 16; 116(25):e139-49.
Sequence variation at multiple loci influences red cell hemoglobin concentration.
Role of chloride in potassium transport through a K-Cl cotransport system in human red blood cells. Am J Physiol. 1989 May; 256(5 Pt 1):C994-1003.
Role of chloride in potassium transport through a K-Cl cotransport system in human red blood cells.
Rifai N, Plebani M, Wu AH, Delanghe J, Brugnara C, Delvin E, Lamb EJ, Ness PM, Wick MR, Berg JP
Full-disclosure in industry-sponsored laboratory medicine research studies: statement by the Consortium of Laboratory Medicine Journal Editors. Clin Chim Acta. 2011 Mar 18; 412(7-8):491-2.
Geltman PL, Meyers AF, Mehta SD, Brugnara C, Villon I, Wu YA, Bauchner H
Daily multivitamins with iron to prevent anemia in high-risk infants: a randomized clinical trial. Pediatrics. 2004 Jul; 114(1):86-93.
Daily multivitamins with iron to prevent anemia in high-risk infants: a randomized clinical trial.
Jarolim P, Rubin HL, Brabec V, Chrobak L, Zolotarev AS, Alper SL, Brugnara C, Wichterle H, Palek J
Mutations of conserved arginines in the membrane domain of erythroid band 3 lead to a decrease in membrane-associated band 3 and to the phenotype of hereditary spherocytosis. Blood. 1995 Feb 01; 85(3):634-40.
Mutations of conserved arginines in the membrane domain of erythroid band 3 lead to a decrease in membrane-associated band 3 and to the phenotype of hereditary spherocytosis.
Olivieri O, De Franceschi L, Capellini MD, Girelli D, Corrocher R, Brugnara C
Oxidative damage and erythrocyte membrane transport abnormalities in thalassemias. Blood. 1994 Jul 01; 84(1):315-20.
Oxidative damage and erythrocyte membrane transport abnormalities in thalassemias.
Sulfhydryl oxidation and activation of red cell K(+)-Cl- cotransport in the transgenic SAD mouse. Am J Physiol. 1995 Oct; 269(4 Pt 1):C899-906.
Sulfhydryl oxidation and activation of red cell K(+)-Cl- cotransport in the transgenic SAD mouse.
Major A, Mathez-Loic F, Rohling R, Gautschi K, Brugnara C
The effect of intravenous iron on the reticulocyte response to recombinant human erythropoietin. Br J Haematol. 1997 Aug; 98(2):292-4.
The effect of intravenous iron on the reticulocyte response to recombinant human erythropoietin.
Head CA, Brugnara C, Martinez-Ruiz R, Kacmarek RM, Bridges KR, Kuter D, Bloch KD, Zapol WM
Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo. J Clin Invest. 1997 Sep 01; 100(5):1193-8.
Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo.
Effect of metabolic depletion on the furosemide-sensitive Na and K fluxes in human red cells. J Membr Biol. 1985; 86(2):145-55.
Effect of metabolic depletion on the furosemide-sensitive Na and K fluxes in human red cells.
Full-disclosure in industry-sponsored laboratory medicine research studies: statement by the Consortium of Laboratory Medicine Journal Editors. Clin Chem Lab Med. 2011 Jan; 49(1):3-4.
An appeal to medical journal editors: the need for a full description of laboratory methods and specimen handling in clinical study reports. Clin Chem Lab Med. 2012 Mar; 50(3):411-3.
Halperin JA, Brugnara C, Nicholson-Weller A
Ca2+-activated K+ efflux limits complement-mediated lysis of human erythrocytes. J Clin Invest. 1989 May; 83(5):1466-71.
Ca2+-activated K+ efflux limits complement-mediated lysis of human erythrocytes.
De Franceschi L, Franco RS, Bertoldi M, Brugnara C, Matté A, Siciliano A, Wieschhaus AJ, Chishti AH, Joiner CH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease. FASEB J. 2013 Feb; 27(2):750-9.
Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease.
Corrocher R, Steinmayr M, Ruzzenente O, Brugnara C, Bertinato L, Mazzi M, Furri C, Bonfanti F, De Sandre G
Elevation of red cell sodium-lithium countertransport in hyperlipidemias. Life Sci. 1985 Feb 18; 36(7):649-55.
Elevation of red cell sodium-lithium countertransport in hyperlipidemias.
Hod EA, Brugnara C, Pilichowska M, Sandhaus LM, Luu HS, Forest SK, Netterwald JC, Reynafarje GM, Kratz A
Automated cell counts on CSF samples: A multicenter performance evaluation of the GloCyte system. Int J Lab Hematol. 2018 Feb; 40(1):56-65.
Automated cell counts on CSF samples: A multicenter performance evaluation of the GloCyte system.
Plasminogen activator inhibitor-1: defining characteristics in the cerebrospinal fluid of newborns. J Pediatr. 2000 Jul; 137(1):132-4.
Plasminogen activator inhibitor-1: defining characteristics in the cerebrospinal fluid of newborns.
Licameli GR, Jones DT, Santosuosso J, Lapp C, Brugnara C, Kenna MA
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
Use of a preoperative bleeding questionnaire in pediatric patients who undergo adenotonsillectomy. Otolaryngol Head Neck Surg. 2008 Oct; 139(4):546-550.
Use of a preoperative bleeding questionnaire in pediatric patients who undergo adenotonsillectomy.
De Franceschi L, Biondani A, Carta F, Turrini F, Laudanna C, Deana R, Brunati AM, Turretta L, Iolascon A, Perrotta S, Elson A, Bulato C, Brugnara C
PTPepsilon has a critical role in signaling transduction pathways and phosphoprotein network topology in red cells. Proteomics. 2008 Nov; 8(22):4695-708.
PTPepsilon has a critical role in signaling transduction pathways and phosphoprotein network topology in red cells.
Halperin JA, Brugnara C, Tosteson MT, Van Ha T, Tosteson DC
Voltage-activated cation transport in human erythrocytes. Am J Physiol. 1989 Nov; 257(5 Pt 1):C986-96.
Voltage-activated cation transport in human erythrocytes.
Ion content and transport and the regulation of volume in sickle cells. Ann N Y Acad Sci. 1989; 565:96-103.
Ion content and transport and the regulation of volume in sickle cells.
In vitro genetic analysis of an erythrocyte determinant of malaria infection. J Infect Dis. 2010 Dec 01; 202(11):1722-7.
In vitro genetic analysis of an erythrocyte determinant of malaria infection.
Chan FY, Robinson J, Brownlie A, Shivdasani RA, Donovan A, Brugnara C, Kim J, Lau BC, Witkowska HE, Zon LI
Characterization of adult alpha- and beta-globin genes in the zebrafish. Blood. 1997 Jan 15; 89(2):688-700.
Characterization of adult alpha- and beta-globin genes in the zebrafish.
Kheir JN, Scharp LA, Borden MA, Swanson EJ, Loxley A, Reese JH, Black KJ, Velazquez LA, Thomson LM, Walsh BK, Mullen KE, Graham DA, Lawlor MW, Brugnara C, Bell DC, McGowan FX
Oxygen gas-filled microparticles provide intravenous oxygen delivery. Sci Transl Med. 2012 Jun 27; 4(140):140ra88.
Oxygen gas-filled microparticles provide intravenous oxygen delivery.
Kaufman HW, Niles JK, Gallagher DR, Rivera A, Alper SL, Brugnara C, Snyder LM
Revised prevalence estimate of possible Hereditary Xerocytosis as derived from a large U.S. Laboratory database. Am J Hematol. 2018 01; 93(1):E9-E12.
Revised prevalence estimate of possible Hereditary Xerocytosis as derived from a large U.S. Laboratory database.
Brugnara C, Canessa M, Cusi D, Tosteson DC
Furosemide-sensitive Na and K fluxes in human red cells. Net uphill Na extrusion and equilibrium properties. J Gen Physiol. 1986 Jan; 87(1):91-112.
Furosemide-sensitive Na and K fluxes in human red cells. Net uphill Na extrusion and equilibrium properties.
Membrane properties of erythrocytes in subjects undergoing multiple blood donations with or without recombinant erythropoietin. Br J Haematol. 1993 May; 84(1):118-30.
Membrane properties of erythrocytes in subjects undergoing multiple blood donations with or without recombinant erythropoietin.
Structure and genetic polymorphism of the mouse KCC1 gene. Biochim Biophys Acta. 2000 Jul 24; 1492(2-3):353-61.
Structure and genetic polymorphism of the mouse KCC1 gene.
Parisotto R, Gore CJ, Hahn AG, Ashenden MJ, Olds TS, Martin DT, Pyne DB, Gawthorn K, Brugnara C
International journal of sports medicine
Reticulocyte parameters as potential discriminators of recombinant human erythropoietin abuse in elite athletes. Int J Sports Med. 2000 Oct; 21(7):471-9.
Reticulocyte parameters as potential discriminators of recombinant human erythropoietin abuse in elite athletes.
Churchill WH, Schmidt B, Lindsey J, Greenberg M, Boudrow S, Brugnara C
Thawing fresh frozen plasma in a microwave oven. A comparison with thawing in a 37 degrees C waterbath. Am J Clin Pathol. 1992 Feb; 97(2):227-32.
Thawing fresh frozen plasma in a microwave oven. A comparison with thawing in a 37 degrees C waterbath.
Pathophysiological-based approaches to treatment of sickle cell disease. Annu Rev Med. 2003; 54:89-112.
Pathophysiological-based approaches to treatment of sickle cell disease.
Khanna R, Chang SH, Andrabi S, Azam M, Kim A, Rivera A, Brugnara C, Low PS, Liu SC, Chishti AH
Headpiece domain of dematin is required for the stability of the erythrocyte membrane. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):6637-42.
Headpiece domain of dematin is required for the stability of the erythrocyte membrane.
Pediatric pathology & molecular medicine
Prevention of red cell dehydration: a possible new treatment for sickle cell disease. Pediatr Pathol Mol Med. 2001 Jan-Feb; 20(1):15-25.
Prevention of red cell dehydration: a possible new treatment for sickle cell disease.
Begenisich T, Nakamoto T, Ovitt CE, Nehrke K, Brugnara C, Alper SL, Melvin JE
Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4. J Biol Chem. 2004 Nov 12; 279(46):47681-7.
Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4.
Liu Y, Pop R, Sadegh C, Brugnara C, Haase VH, Socolovsky M
Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood. 2006 Jul 01; 108(1):123-33.
Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo.
Rust MB, Alper SL, Rudhard Y, Shmukler BE, Vicente R, Brugnara C, Trudel M, Jentsch TJ, Hübner CA
Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice. J Clin Invest. 2007 Jun; 117(6):1708-17.
Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice.
Rivera A, De Franceschi L, Peters LL, Gascard P, Mohandas N, Brugnara C
Effect of complete protein 4.1R deficiency on ion transport properties of murine erythrocytes. Am J Physiol Cell Physiol. 2006 Nov; 291(5):C880-6.
Effect of complete protein 4.1R deficiency on ion transport properties of murine erythrocytes.
Reticulocyte hemoglobin equivalent (Ret He) and assessment of iron-deficient states. Clin Lab Haematol. 2006 Oct; 28(5):303-8.
Reticulocyte hemoglobin equivalent (Ret He) and assessment of iron-deficient states.
Bonfanti F, Corrocher R, Cherubini M, Brugnara C, Fugazzola C, Frasson F
[Multiple renal arteries and arterial hypertension: a review of 337 renal arteriography cases]. Minerva Cardioangiol. 1980 May; 28(5):289-04.
[Multiple renal arteries and arterial hypertension: a review of 337 renal arteriography cases].
Modulation of Gardos channel activity by cytokines in sickle erythrocytes. Blood. 2002 Jan 01; 99(1):357-603.
Modulation of Gardos channel activity by cytokines in sickle erythrocytes.
Membrane transport of Na and K and cell dehydration in sickle erythrocytes. Experientia. 1993 Feb 15; 49(2):100-9.
Membrane transport of Na and K and cell dehydration in sickle erythrocytes.
Bonfanti F, Corrocher R, Bertinato L, Brugnara C, Nortilli R, De Sandre G
[Incidence of retinal and renal complications in arterial hypertension]. Minerva Cardioangiol. 1986 Mar; 34(3):99-105.
[Incidence of retinal and renal complications in arterial hypertension].
De Franceschi L, Platt OS, Malpeli G, Janin A, Scarpa A, Leboeuf C, Beuzard Y, Payen E, Brugnara C
Protective effects of phosphodiesterase-4 (PDE-4) inhibition in the early phase of pulmonary arterial hypertension in transgenic sickle cell mice. FASEB J. 2008 Jun; 22(6):1849-60.
Protective effects of phosphodiesterase-4 (PDE-4) inhibition in the early phase of pulmonary arterial hypertension in transgenic sickle cell mice.
Pedlar CR, Brugnara C, Bruinvels G, Burden R
Iron balance and iron supplementation for the female athlete: A practical approach. Eur J Sport Sci. 2018 Mar; 18(2):295-305.
Iron balance and iron supplementation for the female athlete: A practical approach.
Wieschhaus A, Khan A, Zaidi A, Rogalin H, Hanada T, Liu F, De Franceschi L, Brugnara C, Rivera A, Chishti AH
Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology. Biochem J. 2012 Nov 15; 448(1):141-52.
Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology.
Regulation of erythrocyte cation and water content in sickle cell anemia. Science. 1986 Apr 18; 232(4748):388-90.
Regulation of erythrocyte cation and water content in sickle cell anemia.
Brugnara C, Chambers LA, Malynn E, Goldberg MA, Kruskall MS
Red blood cell regeneration induced by subcutaneous recombinant erythropoietin: iron-deficient erythropoiesis in iron-replete subjects. Blood. 1993 Feb 15; 81(4):956-64.
Red blood cell regeneration induced by subcutaneous recombinant erythropoietin: iron-deficient erythropoiesis in iron-replete subjects.
Red cell indices in classification and treatment of anemias: from M.M. Wintrobes's original 1934 classification to the third millennium. Curr Opin Hematol. 2013 May; 20(3):222-30.
Red cell indices in classification and treatment of anemias: from M.M. Wintrobes's original 1934 classification to the third millennium.
Katodritou E, Zervas K, Terpos E, Brugnara C
Use of erythropoiesis stimulating agents and intravenous iron for cancer and treatment-related anaemia: the need for predictors and indicators of effectiveness has not abated. Br J Haematol. 2008 Jul; 142(1):3-10.
Use of erythropoiesis stimulating agents and intravenous iron for cancer and treatment-related anaemia: the need for predictors and indicators of effectiveness has not abated.
Regulation of cation content and cell volume in hemoglobin erythrocytes from patients with homozygous hemoglobin C disease. J Clin Invest. 1985 May; 75(5):1608-17.
Regulation of cation content and cell volume in hemoglobin erythrocytes from patients with homozygous hemoglobin C disease.
Casula S, Zolotarev AS, Stuart-Tilley AK, Wilhelm S, Shmukler BE, Brugnara C, Alper SL
Chemical crosslinking studies with the mouse Kcc1 K-Cl cotransporter. Blood Cells Mol Dis. 2009 May-Jun; 42(3):233-40.
Chemical crosslinking studies with the mouse Kcc1 K-Cl cotransporter.
An appeal to medical journal editors: the need for a full description of laboratory methods and specimen handling in clinical study reports. Statement by the Consortium of Laboratory Medicine Journal Editors. Ann Clin Biochem. 2012 Mar; 49(Pt 2):105-7.
An appeal to medical journal editors: the need for a full description of laboratory methods and specimen handling in clinical study reports. Statement by the Consortium of Laboratory Medicine Journal Editors.
Full disclosure in industry-sponsored laboratory medicine research studies: statement by the Consortium of Laboratory Medicine Journal Editors. Transfusion. 2012 Jun; 52(6):e15-6.
Lim C, Hansen E, DeSimone TM, Moreno Y, Junker K, Bei A, Brugnara C, Buckee CO, Duraisingh MT
Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans. Nat Commun. 2013; 4:1638.
Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans.
Coupry I, Armsby CC, Alper SL, Brugnara C, Parini A
Clotrimazole and efaroxan inhibit red cell Gardos channel independently of imidazoline I1 and I2 binding sites. Eur J Pharmacol. 1996 Jan 04; 295(1):109-12.
Clotrimazole and efaroxan inhibit red cell Gardos channel independently of imidazoline I1 and I2 binding sites.
Rittenhouse AR, Parker C, Brugnara C, Morgan KG, Alper SL
Inhibition of maxi-K currents in ferret portal vein smooth muscle cells by the antifungal clotrimazole. Am J Physiol. 1997 Jul; 273(1 Pt 1):C45-56.
Inhibition of maxi-K currents in ferret portal vein smooth muscle cells by the antifungal clotrimazole.
De Franceschi L, Villa-Moruzzi E, Fumagalli L, Brugnara C, Turrini F, Motta R, Veghini E, Corato C, Alper SL, Berton G
K-Cl cotransport modulation by intracellular Mg in erythrocytes from mice bred for low and high Mg levels. Am J Physiol Cell Physiol. 2001 Oct; 281(4):C1385-95.
K-Cl cotransport modulation by intracellular Mg in erythrocytes from mice bred for low and high Mg levels.
Weiner DL, Hibberd PL, Betit P, Cooper AB, Botelho CA, Brugnara C
Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease. JAMA. 2003 Mar 05; 289(9):1136-42.
Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease.
Regulation of K-Cl cotransport during reticulocyte maturation and erythrocyte aging in normal and sickle erythrocytes. Am J Physiol Cell Physiol. 2003 Jul; 285(1):C31-8.
Regulation of K-Cl cotransport during reticulocyte maturation and erythrocyte aging in normal and sickle erythrocytes.