DL4DanLevyDan Levy, Ph.D.42.33837200000000-71.1032690000000076150Levy, Dan617/667-0534Associate Professor of Anaesthesiacatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentvivo:descriptiondescriptionDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 108212115985101Jakubowski M, Levy D, Goor-Aryeh I, Collins B, Bajwa Z, Burstein RHeadacheTerminating migraine with allodynia and ongoing central sensitization using parenteral administration of COX1/COX2 inhibitors. Headache. 2005 Jul-Aug; 45(7):850-61.Headache2005-07-01T00:00:002005Terminating migraine with allodynia and ongoing central sensitization using parenteral administration of COX1/COX2 inhibitors.Authorship 10705802Authorship 10705812Authorship 10705822Authorship 10705832Authorship 10705845Authorship 10705852Authorship 1070586128990805Levy D, Abdian L, Dekel-Steinkeller M, Defrin RCephalalgia : an international journal of headacheExperimental evidence for weaker endogenous inhibition of trigeminal pain than extra-trigeminal pain in healthy individuals. Cephalalgia. 2018 06; 38(7):1307-1315.Cephalalgia2017-10-09T00:00:002017Experimental evidence for weaker endogenous inhibition of trigeminal pain than extra-trigeminal pain in healthy individuals.25695654Zhao J, Levy DJournal of neurophysiologyModulation of intracranial meningeal nociceptor activity by cortical spreading depression: a reassessment. J Neurophysiol. 2015 Apr 01; 113(7):2778-85.J Neurophysiol2015-02-18T00:00:002015Modulation of intracranial meningeal nociceptor activity by cortical spreading depression: a reassessment.29703787Zhao J, Levy DThe Journal of neuroscience : the official journal of the Society for NeuroscienceDissociation between CSD-Evoked Metabolic Perturbations and Meningeal Afferent Activation and Sensitization: Implications for Mechanisms of Migraine Headache Onset. J Neurosci. 2018 05 30; 38(22):5053-5066.J Neurosci2018-04-27T00:00:002018Dissociation between CSD-Evoked Metabolic Perturbations and Meningeal Afferent Activation and Sensitization: Implications for Mechanisms of Migraine Headache Onset.29430561Zhao J, Levy DPain reportsThe CGRP receptor antagonist BIBN4096 inhibits prolonged meningeal afferent activation evoked by brief local K+ stimulation but not cortical spreading depression-induced afferent sensitization. Pain Rep. 2018 Jan; 3(1):e632.Pain Rep2017-12-05T00:00:002017The CGRP receptor antagonist BIBN4096 inhibits prolonged meningeal afferent activation evoked by brief local K+ stimulation but not cortical spreading depression-induced afferent sensitization.28127585Zhao J, Levy DeNeuroCortical Spreading Depression Promotes Persistent Mechanical Sensitization of Intracranial Meningeal Afferents: Implications for the Intracranial Mechanosensitivity of Migraine. eNeuro. 2016 Nov-Dec; 3(6).eNeuro2016-12-22T00:00:002016Cortical Spreading Depression Promotes Persistent Mechanical Sensitization of Intracranial Meningeal Afferents: Implications for the Intracranial Mechanosensitivity of Migraine.18254896Zhang XC, Levy DCephalalgia : an international journal of headacheModulation of meningeal nociceptors mechanosensitivity by peripheral proteinase-activated receptor-2: the role of mast cells. Cephalalgia. 2008 Mar; 28(3):276-84.Cephalalgia2008-03-01T00:00:002008Modulation of meningeal nociceptors mechanosensitivity by peripheral proteinase-activated receptor-2: the role of mast cells.11379816Levy D, Kubes P, Zochodne DWJournal of neuropathology and experimental neurologyDelayed peripheral nerve degeneration, regeneration, and pain in mice lacking inducible nitric oxide synthase. J Neuropathol Exp Neurol. 2001 May; 60(5):411-21.J Neuropathol Exp Neurol2001-05-01T00:00:002001Delayed peripheral nerve degeneration, regeneration, and pain in mice lacking inducible nitric oxide synthase.16191393Zochodne DW, Levy DCellular and molecular biology (Noisy-le-Grand, France)Nitric oxide in damage, disease and repair of the peripheral nervous system. Cell Mol Biol (Noisy-le-grand). 2005 Sep 05; 51(3):255-67.Cell Mol Biol (Noisy-le-grand)2005-09-05T00:00:002005Nitric oxide in damage, disease and repair of the peripheral nervous system.20592202Zhang X, Levy D, Noseda R, Kainz V, Jakubowski M, Burstein RThe Journal of neuroscience : the official journal of the Society for NeuroscienceActivation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci. 2010 Jun 30; 30(26):8807-14.J Neurosci2010-06-30T00:00:002010Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura.Authorship 1083294129929378Levy D, Labastida-Ramirez A, MaassenVanDenBrink ACephalalgia : an international journal of headacheCurrent understanding of meningeal and cerebral vascular function underlying migraine headache. Cephalalgia. 2019 11; 39(13):1606-1622.Cephalalgia2018-06-21T00:00:002018Current understanding of meningeal and cerebral vascular function underlying migraine headache.16927959Levy D, Burstein R, Strassman AMHeadacheMast cell involvement in the pathophysiology of migraine headache: A hypothesis. Headache. 2006 Jun; 46 Suppl 1:S13-8.Headache2006-06-01T00:00:002006Mast cell involvement in the pathophysiology of migraine headache: A hypothesis.30073545Bree D, Levy DCurrent pain and headache reportsStrides Toward Better Understanding of Post-Traumatic Headache Pathophysiology Using Animal Models. Curr Pain Headache Rep. 2018 Aug 02; 22(10):67.Curr Pain Headache Rep2018-08-02T00:00:002018Strides Toward Better Understanding of Post-Traumatic Headache Pathophysiology Using Animal Models.20546325Levy DHeadacheMigraine pain and nociceptor activation--where do we stand? Headache. 2010 May; 50(5):909-16.Headache2010-05-01T00:00:002010Migraine pain and nociceptor activation--where do we stand?Principal Investigator2023-05-31Dan Levy2018-09-01MECHANISMS OF CSD-EVOKED PERSISTENT ACTIVATION OF MENINGEAL NOCICEPTORS2R01NS078263-05AB645AndrewBlaeserAndrew Blaeser, Ph.D.173037Blaeser, AndrewResearch Fellow in Anaesthesia19457286Levy DCurrent pain and headache reportsMigraine pain, meningeal inflammation, and mast cells. Curr Pain Headache Rep. 2009 Jun; 13(3):237-40.Curr Pain Headache Rep2009-06-01T00:00:002009Migraine pain, meningeal inflammation, and mast cells.21036476Zhang XC, Kainz V, Burstein R, Levy DPainTumor necrosis factor-a induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions. Pain. 2011 Jan; 152(1):140-149.Pain2010-10-30T00:00:002010Tumor necrosis factor-a induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions.15194863Strassman AM, Levy DNeuroreportThe anti-migraine agent sumatriptan induces a calcium-dependent discharge in meningeal sensory neurons. Neuroreport. 2004 Jun 28; 15(9):1409-12.Neuroreport2004-06-28T00:00:002004The anti-migraine agent sumatriptan induces a calcium-dependent discharge in meningeal sensory neurons.21520229Levy D, Burstein RAnnals of neurologyThe vascular theory of migraine: leave it or love it? Ann Neurol. 2011 Apr; 69(4):600-1.Ann Neurol2011-04-01T00:00:002011The vascular theory of migraine: leave it or love it?21996564Levy D, Moskowitz MA, Noseda R, Burstein RCephalalgia : an international journal of headacheActivation of the migraine pain pathway by cortical spreading depression: do we need more evidence? Cephalalgia. 2012 May; 32(7):581-2.Cephalalgia2011-10-13T00:00:002011Activation of the migraine pain pathway by cortical spreading depression: do we need more evidence?10947811Levy D, Tal M, Höke A, Zochodne DWThe European journal of neuroscienceTransient action of the endothelial constitutive nitric oxide synthase (ecNOS) mediates the development of thermal hypersensitivity following peripheral nerve injury. Eur J Neurosci. 2000 Jul; 12(7):2323-32.Eur J Neurosci2000-07-01T00:00:002000Transient action of the endothelial constitutive nitric oxide synthase (ecNOS) mediates the development of thermal hypersensitivity following peripheral nerve injury.30624345Bree D, Levy DPainIntact mast cell content during mild head injury is required for development of latent pain sensitization: implications for mechanisms underlying post-traumatic headache. Pain. 2019 05; 160(5):1050-1058.Pain2019-05-01T00:00:002019Intact mast cell content during mild head injury is required for development of latent pain sensitization: implications for mechanisms underlying post-traumatic headache.22144718Zhang X, Burstein R, Levy DCephalalgia : an international journal of headacheLocal action of the proinflammatory cytokines IL-1ß and IL-6 on intracranial meningeal nociceptors. Cephalalgia. 2012 Jan; 32(1):66-72.Cephalalgia2011-12-05T00:00:002011Local action of the proinflammatory cytokines IL-1ß and IL-6 on intracranial meningeal nociceptors.D008578Anatomy1101900.856182MeningesD004388Anatomy1492880.831244Dura MaterD009619Anatomy1484290.745189NociceptorsD008881Disorders37016060.406981Migraine DisordersD051298Disorders23690.8737Post-Traumatic HeadacheAnaesthesiaEmeritusHealth Policy and ManagementMedicineNeurologyPathologyNephrologyExperimental MedicineBeth Israel Deaconess Medical CenterBoston Children's HospitalHarvard T.H. Chan School of Public HealthMassachusetts General HospitalCA17CenkAyataCenk Ayata, M.D.42.37730000000000-71.0525000000000019709Ayata, CenkProfessor of NeurologyXX14XiangXuXiang Xu, M.D., Ph.D.42.33837200000000-71.103269000000001738Xu, XiangInstructor in PathologyGB1GabrielBirraneGabriel Birrane, Ph.D.42.33837200000000-71.1032690000000042231Birrane, GabrielInstructor in MedicineJH110JonathanHowlandJonathan Howland, Ph.D.42.33779670000000-71.0705763000000088501Howland, JonathanInstructorMAM1MichaelMoskowitzMichael Arthur Moskowitz, M.D.42.37730000000000-71.0525000000000058997Moskowitz, MichaelProfessor of NeurologyAuthorship 12739911162selected publications5.334870.00256576253research areas3.309170.02398385coauthor of161.26510.599360similar toRB4RamiBursteinRami Burstein, Ph.D.42.33837200000000-71.1032690000000071595Burstein, RamiJohn Hedley-Whyte Professor of AnaesthesiaBMD1BradleyDenkerBradley Mark Denker, M.D.42.33837200000000-71.1032690000000029171Denker, BradleyAssociate Professor of MedicineCW13CliffordWoolfClifford Woolf, M.B.,B.Ch., Ph.D.42.33743600000000-71.1054470000000068111Woolf, CliffordProfessor of NeurologyVLS2VolneySheenVolney L Sheen, M.D., Ph.D.42.33837200000000-71.1032690000000010917Sheen, VolneyAssociate Professor of NeurologyDB12DavidBorsookDavid Borsook, M.B.,B.Ch., Ph.D.42.39465440000000-71.1956711000000045543Borsook, DavidProfessor of Anaesthesia, EmeritusAMS3AndrewStrassmanAndrew Mark Strassman, Ph.D.42.34022770000000-71.1058540000000021556Strassman, AndrewAssociate Professor of AnaesthesiaAuthorship 1360111Authorship 1201833231700010Eger M, Bader M, Bree D, Hadar R, Nemirovski A, Tam J, Levy D, Pick CG, Gabet YScientific reportsBone Anabolic Response in the Calvaria Following Mild Traumatic Brain Injury is Mediated by the Cannabinoid-1 Receptor. Sci Rep. 2019 11 07; 9(1):16196.Sci Rep2019-11-07T00:00:002019Bone Anabolic Response in the Calvaria Following Mild Traumatic Brain Injury is Mediated by the Cannabinoid-1 Receptor.Authorship 12032907true1Associate Professor of NeurologyAssociate Professor of Neurologytrue1Associate Professor of AnaesthesiaAssociate Professor of Anaesthesiatrue1Associate Professor of AnaesthesiaAssociate Professor of Anaesthesiatrue1John Hedley-Whyte Professor of AnaesthesiaJohn Hedley-Whyte Professor of AnaesthesiaAuthorship 1341656Authorship 1251181Authorship 1243691Authorship 167226132077327Bree D, Mackenzie K, Stratton J, Levy DCephalalgia : an international journal of headacheEnhanced post-traumatic headache-like behaviors and diminished contribution of peripheral CGRP in female rats following a mild closed head injury. Cephalalgia. 2020 06; 40(7):748-760.Cephalalgia2020-02-20T00:00:002020Enhanced post-traumatic headache-like behaviors and diminished contribution of peripheral CGRP in female rats following a mild closed head injury.Authorship 12721023Authorship 12721034Authorship 12721041Authorship 1272105231847569Levy D, Gruener H, Riabinin M, Feingold Y, Schreiber S, Pick CG, Defrin RCephalalgia : an international journal of headacheDifferent clinical phenotypes of persistent post-traumatic headache exhibit distinct sensory profiles. Cephalalgia. 2020 06; 40(7):675-688.Cephalalgia2019-12-17T00:00:002019Different clinical phenotypes of persistent post-traumatic headache exhibit distinct sensory profiles.32600065Bree D, Stratton J, Levy DCephalalgia : an international journal of headacheIncreased severity of closed head injury or repetitive subconcussive head impacts enhances post-traumatic headache-like behaviors in a rat model. Cephalalgia. 2020 10; 40(11):1224-1239.Cephalalgia2020-06-29T00:00:002020Increased severity of closed head injury or repetitive subconcussive head impacts enhances post-traumatic headache-like behaviors in a rat model.2025-11-30LEVY, DAN2020-12-15Cortical-meningeal interactions underlying migraine headacheR01NS115972Principal InvestigatorAuthorship 155468234448752Zhao J, Blaeser AS, Levy DPainAstrocytes mediate migraine-related intracranial meningeal mechanical hypersensitivity. Pain. 2021 09 01; 162(9):2386-2396.Pain2021-09-01T00:00:002021Astrocytes mediate migraine-related intracranial meningeal mechanical hypersensitivity.true1Instructor in PathologyInstructor in PathologyThis proposal explores a peripheral neuroimmune mechanism of migraine, involving bidirectional communication between meningeal nociceptors and meningeal immune cells that drives migraine headache. If successful, the project could provide a dramatically better understanding of the role of neurogenic inflammation in migraine pathophysiology and serve as an experimental foundation for future explorations of mechanistic insights into meningeal neuroimmune crosstalk and further testing of specific immune cells and related proinflammatory mediators as potential therapeutic targets for migraine pain.Authorship 14715933Authorship 147159412024-08-31Levy Dan2022-09-01Meningeal Nociceptor-Immune Signaling in Migraine1R21NS130561-019065921Jordan VCOncology (Williston Park, N.Y.)Tamoxifen treatment for breast cancer: concept to gold standard. Oncology (Williston Park). 1997 Feb; 11(2 Suppl 1):7-13.Oncology (Williston Park)1997-02-01T00:00:001997Tamoxifen treatment for breast cancer: concept to gold standard.true1Professor of NeurologyProfessor of NeurologyAuthorship 1530661136913712Levy D, Moskowitz MAAnnual review of neuroscienceMeningeal Mechanisms and the Migraine Connection. Annu Rev Neurosci. 2023 07 10; 46:39-58.Annu Rev Neurosci2023-03-13T00:00:002023Meningeal Mechanisms and the Migraine Connection.Authorship 2556041true1Instructor in MedicineInstructor in MedicineAuthorship 2762543true1Research Fellow in AnaesthesiaResearch Fellow in Anaesthesiatrue1Professor of NeurologyProfessor of Neurologytrue1Associate Professor of MedicineAssociate Professor of Medicine2028-07-31LEVY, DAN2023-08-18Response Properties of Meningeal Afferents in Health and MigraineR01NS133625Principal Investigatortrue1InstructorInstructortrue1Professor of NeurologyProfessor of Neurologytrue1Professor of Anaesthesia, EmeritusProfessor of Anaesthesia, EmeritusAuthorship 3529642Authorship 6437301Authorship 644484122328144Levy DCurrent pain and headache reportsEndogenous mechanisms underlying the activation and sensitization of meningeal nociceptors: the role of immuno-vascular interactions and cortical spreading depression. Curr Pain Headache Rep. 2012 Jun; 16(3):270-7.Curr Pain Headache Rep2012-06-01T00:00:002012Endogenous mechanisms underlying the activation and sensitization of meningeal nociceptors: the role of immuno-vascular interactions and cortical spreading depression.23447360Zhang X, Kainz V, Zhao J, Strassman AM, Levy DAnnals of neurologyVascular extracellular signal-regulated kinase mediates migraine-related sensitization of meningeal nociceptors. Ann Neurol. 2013 Jun; 73(6):741-50.Ann Neurol2013-06-17T00:00:002013Vascular extracellular signal-regulated kinase mediates migraine-related sensitization of meningeal nociceptors.Authorship 6688778Authorship 6688785Authorship 6688793Authorship 6688801Authorship 6688811Authorship 6688824Authorship 668883223497725Arakaki X, McCleary P, Techy M, Chiang J, Kuo L, Fonteh AN, Armstrong B, Levy D, Harrington MGFluids and barriers of the CNSNa,K-ATPase alpha isoforms at the blood-cerebrospinal fluid-trigeminal nerve and blood-retina interfaces in the rat. Fluids Barriers CNS. 2013 Mar 14; 10(1):14.Fluids Barriers CNS2013-03-14T00:00:002013Na,K-ATPase alpha isoforms at the blood-cerebrospinal fluid-trigeminal nerve and blood-retina interfaces in the rat.Authorship 583611Authorship 2362961Authorship 270268124694964Burstein R, Zhang X, Levy D, Aoki KR, Brin MFCephalalgia : an international journal of headacheSelective inhibition of meningeal nociceptors by botulinum neurotoxin type A: therapeutic implications for migraine and other pains. Cephalalgia. 2014 Oct; 34(11):853-69.Cephalalgia2014-04-02T00:00:002014Selective inhibition of meningeal nociceptors by botulinum neurotoxin type A: therapeutic implications for migraine and other pains.Authorship 7588983Authorship 7588992Authorship 7589001Authorship 7589016Authorship 758902224769138Zhao J, Levy DPainThe sensory innervation of the calvarial periosteum is nociceptive and contributes to headache-like behavior. Pain. 2014 Jul; 155(7):1392-1400.Pain2014-04-24T00:00:002014The sensory innervation of the calvarial periosteum is nociceptive and contributes to headache-like behavior.22833613Boes T, Levy DCephalalgia : an international journal of headacheInfluence of sex, estrous cycle, and estrogen on intracranial dural mast cells. Cephalalgia. 2012 Sep; 32(12):924-31.Cephalalgia2012-07-24T00:00:002012Influence of sex, estrous cycle, and estrogen on intracranial dural mast cells.25168788Benromano T, Defrin R, Ahn AH, Zhao J, Pick CG, Levy DEuropean journal of pain (London, England)Mild closed head injury promotes a selective trigeminal hypernociception: implications for the acute emergence of post-traumatic headache. Eur J Pain. 2015 May; 19(5):621-8.Eur J Pain2014-08-29T00:00:002014Mild closed head injury promotes a selective trigeminal hypernociception: implications for the acute emergence of post-traumatic headache.Authorship 743961Authorship 4751921Authorship 963185Authorship 2353432Authorship 686042Authorship 4384942Authorship 5646904Authorship 3373782Authorship 4898901Authorship 292467226566937Levy D, Edut S, Baraz-Goldstein R, Rubovitch V, Defrin R, Bree D, Gariepy H, Zhao J, Pick CGCephalalgia : an international journal of headacheResponses of dural mast cells in concussive and blast models of mild traumatic brain injury in mice: Potential implications for post-traumatic headache. Cephalalgia. 2016 Sep; 36(10):915-23.Cephalalgia2015-11-12T00:00:002015Responses of dural mast cells in concussive and blast models of mild traumatic brain injury in mice: Potential implications for post-traumatic headache.Authorship 52356061Associate Professor6Fellow or Post Doc0Full Professor4InstructorAuthorship 492544127493234Zhao J, Bree D, Harrington MG, Strassman AM, Levy DCephalalgia : an international journal of headacheCranial dural permeability of inflammatory nociceptive mediators: Potential implications for animal models of migraine. Cephalalgia. 2017 Oct; 37(11):1017-1025.Cephalalgia2016-08-19T00:00:002016Cranial dural permeability of inflammatory nociceptive mediators: Potential implications for animal models of migraine.Authorship 9081791Authorship 52030312014-08-31LEVY, DAN2011-09-01Calvarial periosteal afferents in post-traumatic headacheR21NS0778822024-05-31LEVY, DAN2013-07-15MECHANISMS OF CSD-EVOKED PERSISTENT ACTIVATION OF MENINGEAL NOCICEPTORSR01NS0782632012-02-28LEVY, DAN2009-03-01Estrogen Withdrawal and Dural Mast Cells: Implication for Menstrual MigraineR21NS0611162020-05-31LEVY, DAN2014-08-15Peripheral Mechanisms of Posttraumatic HeadacheR01NS0868302015-01-31LEVY, DAN2012-02-10Mechanisms of Alcohol Hangover HeadacheR21AA0203052010-03-31LEVY, DAN2004-04-01Mast Cells: Role in the Pathophysiology of HeadacheR01NS046502Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorAuthorship 3568431Authorship 547052227899434Bree D, Levy DCephalalgia : an international journal of headacheDevelopment of CGRP-dependent pain and headache related behaviours in a rat model of concussion: Implications for mechanisms of post-traumatic headache. Cephalalgia. 2018 02; 38(2):246-258.Cephalalgia2016-12-07T00:00:002016Development of CGRP-dependent pain and headache related behaviours in a rat model of concussion: Implications for mechanisms of post-traumatic headache.Authorship 364221211790814Levy D, Strassman AMThe Journal of physiologyDistinct sensitizing effects of the cAMP-PKA second messenger cascade on rat dural mechanonociceptors. J Physiol. 2002 Jan 15; 538(Pt 2):483-93.J Physiol2002-01-15T00:00:002002Distinct sensitizing effects of the cAMP-PKA second messenger cascade on rat dural mechanonociceptors.15836966Burstein R, Jakubowski M, Levy DPainAnti-migraine action of triptans is preceded by transient aggravation of headache caused by activation of meningeal nociceptors. Pain. 2005 May; 115(1-2):21-8.Pain2005-05-01T00:00:002005Anti-migraine action of triptans is preceded by transient aggravation of headache caused by activation of meningeal nociceptors.15116396Strassman AM, Weissner W, Williams M, Ali S, Levy DThe Journal of comparative neurologyAxon diameters and intradural trajectories of the dural innervation in the rat. J Comp Neurol. 2004 May 31; 473(3):364-76.J Comp Neurol2004-05-31T00:00:002004Axon diameters and intradural trajectories of the dural innervation in the rat.10812256Levy D, Zochodne DWPainIncreased mRNA expression of the B1 and B2 bradykinin receptors and antinociceptive effects of their antagonists in an animal model of neuropathic pain. Pain. 2000 Jun; 86(3):265-271.Pain2000-06-01T00:00:002000Increased mRNA expression of the B1 and B2 bradykinin receptors and antinociceptive effects of their antagonists in an animal model of neuropathic pain.17483291Zhang XC, Strassman AM, Burstein R, Levy DThe Journal of pharmacology and experimental therapeuticsSensitization and activation of intracranial meningeal nociceptors by mast cell mediators. J Pharmacol Exp Ther. 2007 Aug; 322(2):806-12.J Pharmacol Exp Ther2007-05-04T00:00:002007Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators.15056690Levy D, Strassman AMJournal of neurophysiologyModulation of dural nociceptor mechanosensitivity by the nitric oxide-cyclic GMP signaling cascade. J Neurophysiol. 2004 Aug; 92(2):766-72.J Neurophysiol2004-03-31T00:00:002004Modulation of dural nociceptor mechanosensitivity by the nitric oxide-cyclic GMP signaling cascade.16492942Strassman AM, Levy DJournal of neurophysiologyResponse properties of dural nociceptors in relation to headache. J Neurophysiol. 2006 Mar; 95(3):1298-306.J Neurophysiol2006-03-01T00:00:002006Response properties of dural nociceptors in relation to headache.17129298Levy D, Zochodne DWPain practice : the official journal of World Institute of PainNO pain: potential roles of nitric oxide in neuropathic pain. Pain Pract. 2004 Mar; 4(1):11-8.Pain Pract2004-03-01T00:00:002004NO pain: potential roles of nitric oxide in neuropathic pain.10076904Levy D, Höke A, Zochodne DWNeuroscience lettersLocal expression of inducible nitric oxide synthase in an animal model of neuropathic pain. Neurosci Lett. 1999 Feb 05; 260(3):207-9.Neurosci Lett1999-02-05T00:00:001999Local expression of inducible nitric oxide synthase in an animal model of neuropathic pain.9751155Levy D, Zochodne DWThe European journal of neuroscienceLocal nitric oxide synthase activity in a model of neuropathic pain. Eur J Neurosci. 1998 May; 10(5):1846-55.Eur J Neurosci1998-05-01T00:00:001998Local nitric oxide synthase activity in a model of neuropathic pain.22019552Levy D, Kainz V, Burstein R, Strassman AMBrain, behavior, and immunityMast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity. Brain Behav Immun. 2012 Feb; 26(2):311-7.Brain Behav Immun2011-10-12T00:00:002011Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity.21416489Zhang X, Levy D, Kainz V, Noseda R, Jakubowski M, Burstein RAnnals of neurologyActivation of central trigeminovascular neurons by cortical spreading depression. Ann Neurol. 2011 May; 69(5):855-65.Ann Neurol2011-03-17T00:00:002011Activation of central trigeminovascular neurons by cortical spreading depression.2020-03-31LEVY, DAN2017-04-01Chronic two-photon calcium imaging of intracranial meningeal afferents in awake behaving miceR21NS101405Principal Investigator16141951Burstein R, Levy D, Jakubowski MRevue neurologiqueEffects of sensitization of trigeminovascular neurons to triptan therapy during migraine. Rev Neurol (Paris). 2005 Jul; 161(6-7):658-60.Rev Neurol (Paris)2005-07-01T00:00:002005Effects of sensitization of trigeminovascular neurons to triptan therapy during migraine.16240341Levy D, Burstein R, Strassman AMAnnals of neurologyCalcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine. Ann Neurol. 2005 Nov; 58(5):698-705.Ann Neurol2005-11-01T00:00:002005Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine.17651900Jakubowski M, Levy D, Kainz V, Zhang XC, Kosaras B, Burstein RNeuroscienceSensitization of central trigeminovascular neurons: blockade by intravenous naproxen infusion. Neuroscience. 2007 Aug 24; 148(2):573-83.Neuroscience2007-07-25T00:00:002007Sensitization of central trigeminovascular neurons: blockade by intravenous naproxen infusion.17459586Levy D, Burstein R, Kainz V, Jakubowski M, Strassman AMPainMast cell degranulation activates a pain pathway underlying migraine headache. Pain. 2007 Jul; 130(1-2):166-76.Pain2007-04-24T00:00:002007Mast cell degranulation activates a pain pathway underlying migraine headache.12466427Levy D, Strassman AMJournal of neurophysiologyMechanical response properties of A and C primary afferent neurons innervating the rat intracranial dura. 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