Jiang S, Avraham HK, Park SY, Kim TA, Bu X, Seng S, Avraham S
Process elongation of oligodendrocytes is promoted by the Kelch-related actin-binding protein Mayven. J Neurochem. 2005 Mar; 92(5):1191-203.
Process elongation of oligodendrocytes is promoted by the Kelch-related actin-binding protein Mayven.
Nombela-Arrieta C, Pivarnik G, Winkel B, Canty KJ, Harley B, Mahoney JE, Park SY, Lu J, Protopopov A, Silberstein LE
Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment. Nat Cell Biol. 2013 May; 15(5):533-43.
Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment.
Glodek AM, Le Y, Dykxhoorn DM, Park SY, Mostoslavsky G, Mulligan R, Lieberman J, Beggs HE, Honczarenko M, Silberstein LE
Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells. Leukemia. 2007 Aug; 21(8):1723-32.
Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells.
Le Y, Zhu BM, Harley B, Park SY, Kobayashi T, Manis JP, Luo HR, Yoshimura A, Hennighausen L, Silberstein LE
SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis. Immunity. 2007 Nov; 27(5):811-23.
SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis.
Professor of Stem Cell and Regenerative Biology and Gerald and Darlene Jordan Professor of Medicine
Caroline Shields Walker Professor of Medicine
Richard and Susan Smith Professor of Medicine
Professor of Stem Cell and Regenerative Biology and Grousbeck Professor of Pediatrics, Harvard Medical School
A. Werk Cook Professor of Radiation Oncology (Tumor Biology)
Park SY, Matte A, Jung Y, Ryu J, Anand WB, Han EY, Liu M, Carbone C, Melisi D, Nagasawa T, Locascio JJ, Lin CP, Silberstein LE, De Franceschi L
Pathologic angiogenesis in the bone marrow of humanized sickle cell mice is reversed by blood transfusion. Blood. 2020 06 04; 135(23):2071-2084.
Pathologic angiogenesis in the bone marrow of humanized sickle cell mice is reversed by blood transfusion.
Xie X, Shi Q, Wu P, Zhang X, Kambara H, Su J, Yu H, Park SY, Guo R, Ren Q, Zhang S, Xu Y, Silberstein LE, Cheng T, Ma F, Li C, Luo HR
Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection. Nat Immunol. 2020 09; 21(9):1119-1133.
Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection.
Fan Y, Teng Y, Loison F, Pang A, Kasorn A, Shao X, Zhang C, Ren Q, Yu H, Zheng Y, Cancelas JA, Manis J, Chai L, Park SY, Zhao L, Xu Y, Feng S, Silberstein LE, Ma F, Luo HR
Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion. Sci Transl Med. 2021 07 28; 13(604).
Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion.
Novel Strategies to Improve Blood Transfusion Practice
PI (Cytometry and Imaging Core); Co-Investigator (Project 1)
Transcranial focused ultrasound to the thalamus alters anesthesia time in rats. Neuroreport. 2011 Oct 26; 22(15):783-7.
Transcranial focused ultrasound to the thalamus alters anesthesia time in rats.
Kim H, Taghados SJ, Fischer K, Maeng LS, Park S, Yoo SS
Noninvasive transcranial stimulation of rat abducens nerve by focused ultrasound. Ultrasound Med Biol. 2012 Sep; 38(9):1568-75.
Noninvasive transcranial stimulation of rat abducens nerve by focused ultrasound.
Kumar L, Chou J, Yee CS, Borzutzky A, Vollmann EH, von Andrian UH, Park SY, Hollander G, Manis JP, Poliani PL, Geha RS
Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function. J Exp Med. 2014 May 05; 211(5):929-42.
Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function.
Yang PS, Kim H, Lee W, Bohlke M, Park S, Maher TJ, Yoo SS
Transcranial focused ultrasound to the thalamus is associated with reduced extracellular GABA levels in rats. Neuropsychobiology. 2012; 65(3):153-60.
Transcranial focused ultrasound to the thalamus is associated with reduced extracellular GABA levels in rats.
Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C, Mondal S, Sun Y, Zhu H, Chai L, Silberstein LE, Cheng T, Luo HR
Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis. Immunity. 2015 Jan 20; 42(1):159-71.
Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis.
Ciuculescu MF, Park SY, Canty K, Mathieu R, Silberstein LE, Williams DA
Perivascular deletion of murine Rac reverses the ratio of marrow arterioles and sinusoid vessels and alters hematopoiesis in vivo. Blood. 2015 May 14; 125(20):3105-13.
Perivascular deletion of murine Rac reverses the ratio of marrow arterioles and sinusoid vessels and alters hematopoiesis in vivo.
Bajrami B, Zhu H, Kwak HJ, Mondal S, Hou Q, Geng G, Karatepe K, Zhang YC, Nombela-Arrieta C, Park SY, Loison F, Sakai J, Xu Y, Silberstein LE, Luo HR
G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling. J Exp Med. 2016 09 19; 213(10):1999-2018.
G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling.
Molecular Mechanisms of Blood Cell Transfusion
PI (Cytometry Core); Co-Investigator (Project 1)
Sousa-Lima I, Park SY, Chung M, Jung HJ, Kang MC, Gaspar JM, Seo JA, Macedo MP, Park KS, Mantzoros C, Lee SH, Kim YB
Methylsulfonylmethane (MSM), an organosulfur compound, is effective against obesity-induced metabolic disorders in mice. Metabolism. 2016 10; 65(10):1508-21.
Methylsulfonylmethane (MSM), an organosulfur compound, is effective against obesity-induced metabolic disorders in mice.
Avraham H, Park SY, Schinkmann K, Avraham S
RAFTK/Pyk2-mediated cellular signalling. Cell Signal. 2000 Mar; 12(3):123-33.
RAFTK/Pyk2-mediated cellular signalling.
Characterization of the tyrosine kinases RAFTK/Pyk2 and FAK in nerve growth factor-induced neuronal differentiation. J Biol Chem. 2000 Jun 30; 275(26):19768-77.
Characterization of the tyrosine kinases RAFTK/Pyk2 and FAK in nerve growth factor-induced neuronal differentiation.
McShan GD, Zagozdzon R, Park SY, Zrihan-Licht S, Fu Y, Avraham S, Avraham H
Csk homologous kinase associates with RAFTK/Pyk2 in breast cancer cells and negatively regulates its activation and breast cancer cell migration. Int J Oncol. 2002 Jul; 21(1):197-205.
Csk homologous kinase associates with RAFTK/Pyk2 in breast cancer cells and negatively regulates its activation and breast cancer cell migration.
Zhu H, Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C, Mondal S, Kambara H, Yu H, Chai L, Silberstein LE, Cheng T, Luo HR
Journal of immunology (Baltimore, Md. : 1950)
Reactive Oxygen Species-Producing Myeloid Cells Act as a Bone Marrow Niche for Sterile Inflammation-Induced Reactive Granulopoiesis. J Immunol. 2017 04 01; 198(7):2854-2864.
Reactive Oxygen Species-Producing Myeloid Cells Act as a Bone Marrow Niche for Sterile Inflammation-Induced Reactive Granulopoiesis.
RAFTK/Pyk2 regulates EGF-induced PC12 cell spreading and movement. Cell Signal. 2007 Feb; 19(2):289-300.
RAFTK/Pyk2 regulates EGF-induced PC12 cell spreading and movement.
RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner. J Biol Chem. 2004 Aug 06; 279(32):33315-22.
RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner.
Lu J, Sun Y, Nombela-Arrieta C, Du KP, Park SY, Chai L, Walkley C, Luo HR, Silberstein LE
Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion. Exp Hematol. 2012 Apr; 40(4):307-17.e3.
Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion.
Park SY, Wolfram P, Canty K, Harley B, Nombela-Arrieta C, Pivarnik G, Manis J, Beggs HE, Silberstein LE
Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments. J Immunol. 2013 Feb 01; 190(3):1094-102.
Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments.
Jia Y, Loison F, Hattori H, Li Y, Erneux C, Park SY, Gao C, Chai L, Silberstein LE, Schurmans S, Luo HR
Proceedings of the National Academy of Sciences of the United States of America
Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4739-44.
Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis.
Koziak K, Kaczmarek E, Park SY, Fu Y, Avraham S, Avraham H
RAFTK/Pyk2 involvement in platelet activation is mediated by phosphoinositide 3-kinase. Br J Haematol. 2001 Jul; 114(1):134-40.
RAFTK/Pyk2 involvement in platelet activation is mediated by phosphoinositide 3-kinase.
Mollova M, Bersell K, Walsh S, Savla J, Das LT, Park SY, Silberstein LE, Dos Remedios CG, Graham D, Colan S, Kühn B
Cardiomyocyte proliferation contributes to heart growth in young humans. Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1446-51.
Cardiomyocyte proliferation contributes to heart growth in young humans.
RAFTK/Pyk2 mediates LPA-induced PC12 cell migration. Cell Signal. 2006 Jul; 18(7):1063-71.
RAFTK/Pyk2 mediates LPA-induced PC12 cell migration.