Dowling, David
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Authorship 1049731
type: Authorship
author rank in publication: 11
linked author: Dowling, David
linked information resource: Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn.

Authorship 1062007
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author rank in publication: 2
linked author: Dowling, David
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/102860828

https://connects.catalyst.harvard.edu/Profiles/profile/102860828
PubMed Identifier: 29715306
author list: Speer EM, Dowling DJ, Xu J, Ozog LS, Mathew JA, Chander A, Yin D, Levy O
published in: PloS one
information resource reference: Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro. PLoS One. 2018; 13(5):e0196352.
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label: Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro.

The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function.
PubMed Identifier: 19332532
author list: Hamilton CM, Dowling DJ, Loscher CE, Morphew RM, Brophy PM, O'Neill SM
published in: Infection and immunity
information resource reference: The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function. Infect Immun. 2009 Jun; 77(6):2488-98.
journal title abbreviation: Infect Immun
publication date: 2009-03-30T00:00:00
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Xia, Ning
eCommons Login: NX7
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person in primary position: Instructor in Neurology
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The Sigma class glutathione transferase from the liver fluke Fasciola hepatica.
PubMed Identifier: 22666515
author list: LaCourse EJ, Perally S, Morphew RM, Moxon JV, Prescott M, Dowling DJ, O'Neill SM, Kipar A, Hetzel U, Hoey E, Zafra R, Buffoni L, Pérez Arévalo J, Brophy PM
published in: PLoS neglected tropical diseases
information resource reference: The Sigma class glutathione transferase from the liver fluke Fasciola hepatica. PLoS Negl Trop Dis. 2012; 6(5):e1666.
journal title abbreviation: PLoS Negl Trop Dis
publication date: 2012-05-29T00:00:00
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Authorship 1097367
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author rank in publication: 4
linked author: Dowling, David
linked information resource: Pentoxifylline Alone or in Combination with Gentamicin or Vancomycin Inhibits Live Microbe-Induced Proinflammatory Cytokine Production in Human Cord Blood and Cord Blood Monocytes In Vitro.

Pentoxifylline Alone or in Combination with Gentamicin or Vancomycin Inhibits Live Microbe-Induced Proinflammatory Cytokine Production in Human Cord Blood and Cord Blood Monocytes In Vitro.
PubMed Identifier: 30275087
author list: Speer EM, Diago-Navarro E, Ozog LS, Dowling DJ, Hou W, Raheel M, Fries BC, Levy O
published in: Antimicrobial agents and chemotherapy
information resource reference: Pentoxifylline Alone or in Combination with Gentamicin or Vancomycin Inhibits Live Microbe-Induced Proinflammatory Cytokine Production in Human Cord Blood and Cord Blood Monocytes In Vitro. Antimicrob Agents Chemother. 2018 12; 62(12).
journal title abbreviation: Antimicrob Agents Chemother
publication date: 2018-11-26T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 11105
type: Authorship
author rank in publication: 2
linked author: Dowling, David
linked information resource: Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways.

Authorship 1115738
type: Authorship
author rank in publication: 2
linked author: Dowling, David
linked information resource: Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro.

Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro.
PubMed Identifier: 30478007
author list: Queenan AM, Dowling DJ, Cheng WK, Faé K, Fernandez J, Flynn PJ, Joshi S, Brightman SE, Ramirez J, Serroyen J, Wiertsema S, Fortanier A, van den Dobbelsteen G, Levy O, Poolman J
published in: Vaccine
information resource reference: Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro. Vaccine. 2019 01 03; 37(1):80-89.
journal title abbreviation: Vaccine
publication date: 2018-11-23T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways.
PubMed Identifier: 22521247
author list: Philbin VJ, Dowling DJ, Gallington LC, Cortés G, Tan Z, Suter EE, Chi KW, Shuckett A, Stoler-Barak L, Tomai M, Miller RL, Mansfield K, Levy O
published in: The Journal of allergy and clinical immunology
information resource reference: Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways. J Allergy Clin Immunol. 2012 Jul; 130(1):195-204.e9.
journal title abbreviation: J Allergy Clin Immunol
publication date: 2012-04-21T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

The effects of Fasciola hepatica tegumental antigens on mast cell function.
PubMed Identifier: 23535069
author list: Vukman KV, Adams PN, Dowling D, Metz M, Maurer M, O'Neill SM
published in: International journal for parasitology
information resource reference: The effects of Fasciola hepatica tegumental antigens on mast cell function. Int J Parasitol. 2013 Jun; 43(7):531-9.
journal title abbreviation: Int J Parasitol
publication date: 2013-03-25T00:00:00
year: 2013
type: Academic Article
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Authorship 116085
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author rank in publication: 3
linked author: Dowling, David
linked information resource: Plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum.

Viral Vaccines
MeSH DescriptorUI: D014765
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number of authors: 257
number of publications: 615
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Toll-Like Receptor 8
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Adjuvants, Immunologic
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Toll-Like Receptor 7
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uniqueness weight: 0.875392
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Authorship 1148557
type: Authorship
author rank in publication: 1
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linked information resource: Recent Advances in the Discovery and Delivery of TLR7/8 Agonists as Vaccine Adjuvants.

Recent Advances in the Discovery and Delivery of TLR7/8 Agonists as Vaccine Adjuvants.
PubMed Identifier: 31022686
author list: Dowling DJ
published in: ImmunoHorizons
information resource reference: Recent Advances in the Discovery and Delivery of TLR7/8 Agonists as Vaccine Adjuvants. Immunohorizons. 2018 07 02; 2(6):185-197.
journal title abbreviation: Immunohorizons
publication date: 2018-07-02T00:00:00
year: 2018
type: Academic Article
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type: Document
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Vaccines
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Beth Israel Deaconess Medical Center
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Brigham and Women's Hospital
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Boston Children's Hospital
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Massachusetts General Hospital
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Shrier, Lydia
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Schizer, Miriam
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person in primary position: Assistant Professor of Pediatrics
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selected publications
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Barouch, Dan
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Barman, Soumik
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van Haren, Simon
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Baden, Lindsey
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Fox, Victor
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Rubin, Eric
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Levy, Ofer
eCommons Login: OL1
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person in primary position: Professor of Pediatrics
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Sanchez-Schmitz, Guzman
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person in primary position: Instructor in Pediatrics
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MPI - David Dowling
type: Researcher Role
description: This project characterized mechanisms underlying BCG’s immunostimulation of neonatal immunity, including “trained” immunity, and applied these towards rational design of scalable, synthetic neonatal subunit vaccine formulations.
researcher role of: Dowling, David
contributes to: Leveraging immunostimulatory pathways that enhance BCG vaccination for the rational design of synthetic neonatal vaccine formulations

Leveraging immunostimulatory pathways that enhance BCG vaccination for the rational design of synthetic neonatal vaccine formulations
end date: 2020-10-31
principal investigator name: SCOTT, EVAN A
start date: 2018-11-08
type: Grant
sponsor award id: R21AI137932

Authorship 1217307
type: Authorship
author rank in publication: 2
linked author: Dowling, David
linked information resource: Toward precision adjuvants: optimizing science and safety.

Toward precision adjuvants: optimizing science and safety.
PubMed Identifier: 31904601
author list: Nanishi E, Dowling DJ, Levy O
published in: Current opinion in pediatrics
information resource reference: Toward precision adjuvants: optimizing science and safety. Curr Opin Pediatr. 2020 02; 32(1):125-138.
journal title abbreviation: Curr Opin Pediatr
publication date: 2020-02-01T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1233884
type: Authorship
author rank in publication: 3
linked author: Dowling, David
linked information resource: The TLR5 Agonist Flagellin Shapes Phenotypical and Functional Activation of Lung Mucosal Antigen Presenting Cells in Neonatal Mice.

The TLR5 Agonist Flagellin Shapes Phenotypical and Functional Activation of Lung Mucosal Antigen Presenting Cells in Neonatal Mice.
PubMed Identifier: 32132997
author list: Sharma P, Levy O, Dowling DJ
published in: Frontiers in immunology
information resource reference: The TLR5 Agonist Flagellin Shapes Phenotypical and Functional Activation of Lung Mucosal Antigen Presenting Cells in Neonatal Mice. Front Immunol. 2020; 11:171.
journal title abbreviation: Front Immunol
publication date: 2020-02-18T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1236058
type: Authorship
author rank in publication: 6
linked author: Dowling, David
linked information resource: BCG as a Case Study for Precision Vaccine Development: Lessons From Vaccine Heterogeneity, Trained Immunity, and Immune Ontogeny.

BCG as a Case Study for Precision Vaccine Development: Lessons From Vaccine Heterogeneity, Trained Immunity, and Immune Ontogeny.
PubMed Identifier: 32218774
author list: Angelidou A, Diray-Arce J, Conti MG, Smolen KK, van Haren SD, Dowling DJ, Husson RN, Levy O
published in: Frontiers in microbiology
information resource reference: BCG as a Case Study for Precision Vaccine Development: Lessons From Vaccine Heterogeneity, Trained Immunity, and Immune Ontogeny. Front Microbiol. 2020; 11:332.
journal title abbreviation: Front Microbiol
publication date: 2020-03-11T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Principal Investigator
type: Researcher Role
description: This contract is to discover novel adjuvants for influenza and coronavirus vaccines by screening ~100,000 small molecules for activity towards human leukocytes, including newborn and elderly leukocytes, define mechanisms of action, and develop formulated analogs for in vivo murine and ferret studies.
researcher role of: Dowling, David
contributes to: Vaccine Adjuvant Discovery Program

Vaccine Adjuvant Discovery Program
end date: 2024-09-30
principal investigator name: David Dowling
start date: 2019-10-01
type: Grant
sponsor award id: 75N93019C00044

The sixth revolution in pediatric vaccinology: immunoengineering and delivery systems.
PubMed Identifier: 32927471
author list: Soni D, Bobbala S, Li S, Scott EA, Dowling DJ
published in: Pediatric research
information resource reference: The sixth revolution in pediatric vaccinology: immunoengineering and delivery systems. Pediatr Res. 2021 05; 89(6):1364-1372.
journal title abbreviation: Pediatr Res
publication date: 2020-09-14T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1284222
type: Authorship
author rank in publication: 5
linked author: Dowling, David
linked information resource: The sixth revolution in pediatric vaccinology: immunoengineering and delivery systems.

Brook, Byron
eCommons Login: byb097
first name: Byron
last name: Brook
full name: Byron Brook, Ph.D.
has faculty rank: Instructor
Person ID: 194393
person in primary position: Instructor in Pediatrics
type: Agent
type: Person
preferred title: Instructor in Pediatrics

Neonatal monocytes demonstrate impaired homeostatic extravasation into a microphysiological human vascular model.
PubMed Identifier: 33082466
author list: Sanchez-Schmitz G, Morrocchi E, Cooney M, Soni D, Khatun R, Palma P, Dowling DJ, Levy O
published in: Scientific reports
information resource reference: Neonatal monocytes demonstrate impaired homeostatic extravasation into a microphysiological human vascular model. Sci Rep. 2020 10 20; 10(1):17836.
journal title abbreviation: Sci Rep
publication date: 2020-10-20T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1298007
type: Authorship
author rank in publication: 7
linked author: Dowling, David
linked information resource: Neonatal monocytes demonstrate impaired homeostatic extravasation into a microphysiological human vascular model.

Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference.
PubMed Identifier: 33178222
author list: Soni D, Van Haren SD, Idoko OT, Evans JT, Diray-Arce J, Dowling DJ, Levy O
published in: Frontiers in immunology
information resource reference: Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference. Front Immunol. 2020; 11:590373.
journal title abbreviation: Front Immunol
publication date: 2020-10-15T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1305444
type: Authorship
author rank in publication: 6
linked author: Dowling, David
linked information resource: Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference.

Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity.
PubMed Identifier: 34031655
author list: Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Brook B, Chen J, Diray-Arce J, Doss-Gollin S, Leon M, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, Dowling DJ
published in: bioRxiv : the preprint server for biology
information resource reference: Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity. bioRxiv. 2021 May 21.
journal title abbreviation: bioRxiv
publication date: 2021-05-21T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1359512
type: Authorship
author rank in publication: 42
linked author: Dowling, David
linked information resource: Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity.

An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice.
PubMed Identifier: 34783582
author list: Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Cavazzoni CB, Brook B, Barman S, Chen J, Diray-Arce J, Doss-Gollin S, De Leon M, Prevost-Reilly A, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Sage PT, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, Dowling DJ
published in: Science translational medicine
information resource reference: An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice. Sci Transl Med. 2022 Jan 26; 14(629):eabj5305.
journal title abbreviation: Sci Transl Med
publication date: 2022-01-26T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1407834
type: Authorship
author rank in publication: 46
linked author: Dowling, David
linked information resource: An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice.

Authorship 1429113
type: Authorship
author rank in publication: 27
linked author: Dowling, David
linked information resource: An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity.

An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity.
PubMed Identifier: 35148840
author list: Borriello F, Poli V, Shrock E, Spreafico R, Liu X, Pishesha N, Carpenet C, Chou J, Di Gioia M, McGrath ME, Dillen CA, Barrett NA, Lacanfora L, Franco ME, Marongiu L, Iwakura Y, Pucci F, Kruppa MD, Ma Z, Lowman DW, Ensley HE, Nanishi E, Saito Y, O'Meara TR, Seo HS, Dhe-Paganon S, Dowling DJ, Frieman M, Elledge SJ, Levy O, Irvine DJ, Ploegh HL, Williams DL, Zanoni I
published in: Cell
information resource reference: An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity. Cell. 2022 02 17; 185(4):614-629.e21.
journal title abbreviation: Cell
publication date: 2022-02-10T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Principal Investigator
type: Researcher Role
description: This contract is to develop an effective adjuvanted anti-fentanyl vaccine via the induction of anti-fentanyl antibodies that will block the movement of fentanyl from the bloodstream to the brain where it can suppress respiration and cause death. The production of vaccine formulation pilot lots will be completed under good laboratory practice (GLP) to support Investigational New Drug application (IND)-enabling activities in preparation for chemistry, manufacturing, and control (CMC) process-development and current Good Manufacturing Practice (cGMP) production grade formulation scaled up, to support animal and early-stage Phase I/II safety and immunogenicity human clinical trials in adults and/or youths with opioid use disorder (OUD).
researcher role of: Dowling, David
contributes to: Development of Vaccines for the Treatment of Opioid Use Disorder

Authorship 1429386
type: Authorship
author rank in publication: 5
linked author: Dowling, David
linked information resource: Precision Vaccine Development: Cues From Natural Immunity.

https://connects.catalyst.harvard.edu/Profiles/profile/193218176
type: Researcher Role
description: This contract focuses on development of novel adjuvanted SARS-CoV-2 vaccines tailored for use in older humans.
researcher role of: Dowling, David
contributes to: Vaccine Adjuvant Discovery Program - SARS-CoV-2 Vaccine Development

https://connects.catalyst.harvard.edu/Profiles/profile/193218500
type: Researcher Role
description: This award advances the clinical development of patented adjuvants developed within the Dowling Laboratory.
researcher role of: Dowling, David
contributes to: Adjuvant optimization via structure-activity relationship studies

https://connects.catalyst.harvard.edu/Profiles/profile/193218777
type: Researcher Role
description: This contract supplement supports the development of novel TLR7/8 agonist adjuvants for use in influenza and coronavirus vaccines.
researcher role of: Dowling, David
contributes to: Advancement of TLR7/8 Adjuvant Development

Vaccine Adjuvant Discovery Program - SARS-CoV-2 Vaccine Development
end date: 2022-09-30
principal investigator name: David Dowling
start date: 2020-04-30
type: Grant
sponsor award id: 75N93019C00044

Adjuvant optimization via structure-activity relationship studies
end date: 2023-09-30
principal investigator name: David Dowling
start date: 2021-07-30
type: Grant
sponsor award id: TDF2019

Development of Vaccines for the Treatment of Opioid Use Disorder
end date: 2025-09-30
principal investigator name: David Dowling
start date: 2020-10-01
type: Grant
sponsor award id: 75N93020C00038

Advancement of TLR7/8 Adjuvant Development
end date: 2024-04-30
principal investigator name: David Dowling
start date: 2022-04-30
type: Grant
sponsor award id: 75N93019C00044

Precision Vaccine Development: Cues From Natural Immunity.
PubMed Identifier: 35222350
author list: Barman S, Soni D, Brook B, Nanishi E, Dowling DJ
published in: Frontiers in immunology
information resource reference: Precision Vaccine Development: Cues From Natural Immunity. Front Immunol. 2021; 12:662218.
journal title abbreviation: Front Immunol
publication date: 2022-02-10T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 256103
type: Authorship
author rank in publication: 1
linked author: Dowling, David
linked information resource: Ascaris lumbricoides pseudocoelomic body fluid induces a partially activated dendritic cell phenotype with Th2 promoting ability in vivo.

Authorship 1443655
type: Authorship
author rank in publication: 4
linked author: Dowling, David
linked information resource: Precision Vaccine Adjuvants for Older Adults: A Scoping Review.

Precision Vaccine Adjuvants for Older Adults: A Scoping Review.
PubMed Identifier: 35439286
author list: Nanishi E, Angelidou A, Rotman C, Dowling DJ, Levy O, Ozonoff A
published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
information resource reference: Precision Vaccine Adjuvants for Older Adults: A Scoping Review. Clin Infect Dis. 2022 08 15; 75(Suppl 1):S72-S80.
journal title abbreviation: Clin Infect Dis
publication date: 2022-08-15T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1448521
type: Authorship
author rank in publication: 1
linked author: Dowling, David
linked information resource: A Precision Adjuvant Approach to Enhance Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines Optimized for Immunologically Distinct Vulnerable Populations.

A Precision Adjuvant Approach to Enhance Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines Optimized for Immunologically Distinct Vulnerable Populations.
PubMed Identifier: 35512145
author list: Dowling DJ, Levy O
published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
information resource reference: A Precision Adjuvant Approach to Enhance Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines Optimized for Immunologically Distinct Vulnerable Populations. Clin Infect Dis. 2022 08 15; 75(Suppl 1):S30-S36.
journal title abbreviation: Clin Infect Dis
publication date: 2022-08-15T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1451594
type: Authorship
author rank in publication: 5
linked author: Dowling, David
linked information resource: Acceptability of a Fentanyl Vaccine to Prevent Opioid Overdose and Need for Personalized Decision-Making.

Acceptability of a Fentanyl Vaccine to Prevent Opioid Overdose and Need for Personalized Decision-Making.
PubMed Identifier: 35579508
author list: Weitzman ER, Kossowsky J, Blakemore LM, Cox R, Dowling DJ, Levy O, Needles EW, Levy S
published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
information resource reference: Acceptability of a Fentanyl Vaccine to Prevent Opioid Overdose and Need for Personalized Decision-Making. Clin Infect Dis. 2022 08 15; 75(Suppl 1):S98-S109.
journal title abbreviation: Clin Infect Dis
publication date: 2022-08-15T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells.
PubMed Identifier: 35860217
author list: Chew K, Lee B, van Haren SD, Nanishi E, O'Meara T, Splaine JB, DeLeon M, Soni D, Seo HS, Dhe-Paganon S, Ozonoff A, Smith JA, Levy O, Dowling DJ
published in: bioRxiv : the preprint server for biology
information resource reference: Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells. bioRxiv. 2022 Jul 11.
journal title abbreviation: bioRxiv
publication date: 2022-07-11T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1490633
type: Authorship
author rank in publication: 21
linked author: Dowling, David
linked information resource: mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant.

Authorship 1490349
type: Authorship
author rank in publication: 1
linked author: Dowling, David
linked information resource: Development of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination.

Authorship 1485092
type: Authorship
author rank in publication: 16
linked author: Dowling, David
linked information resource: Shaping Neonatal Immunization by Tuning the Delivery of Synergistic Adjuvants via Nanocarriers.

mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant.
PubMed Identifier: 35933439
author list: Nanishi E, McGrath ME, O'Meara TR, Barman S, Yu J, Wan H, Dillen CA, Menon M, Seo HS, Song K, Xu AZ, Sebastian L, Brook B, Bosco AN, Borriello F, Ernst RK, Barouch DH, Dhe-Paganon S, Levy O, Frieman MB, Dowling DJ
published in: Communications biology
information resource reference: mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant. Commun Biol. 2022 08 06; 5(1):790.
journal title abbreviation: Commun Biol
publication date: 2022-08-06T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Shaping Neonatal Immunization by Tuning the Delivery of Synergistic Adjuvants via Nanocarriers.
PubMed Identifier: 36028220
author list: Barman S, Borriello F, Brook B, Pietrasanta C, De Leon M, Sweitzer C, Menon M, van Haren SD, Soni D, Saito Y, Nanishi E, Yi S, Bobbala S, Levy O, Scott EA, Dowling DJ
published in: ACS chemical biology
information resource reference: Shaping Neonatal Immunization by Tuning the Delivery of Synergistic Adjuvants via Nanocarriers. ACS Chem Biol. 2022 09 16; 17(9):2559-2571.
journal title abbreviation: ACS Chem Biol
publication date: 2022-08-26T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Development of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination.
PubMed Identifier: 36258023
author list: Dowling DJ, Barman S, Smith AJ, Borriello F, Chaney D, Brightman SE, Melhem G, Brook B, Menon M, Soni D, Schüller S, Siram K, Nanishi E, Bazin HG, Burkhart DJ, Levy O, Evans JT
published in: Scientific reports
information resource reference: Development of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination. Sci Rep. 2022 10 18; 12(1):16860.
journal title abbreviation: Sci Rep
publication date: 2022-10-18T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1512349
type: Authorship
author rank in publication: 21
linked author: Dowling, David
linked information resource: The mRNA vaccine BNT162b2 demonstrates impaired TH1 immunogenicity in human elders in vitro and aged mice in vivo.

Authorship 1511637
type: Authorship
author rank in publication: 13
linked author: Dowling, David
linked information resource: Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.

Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.
PubMed Identifier: 36523401
author list: O'Meara TR, Nanishi E, McGrath ME, Barman S, Dong D, Dillen C, Menon M, Seo HS, Dhe-Paganon S, Ernst RK, Levy O, Frieman MB, Dowling DJ
published in: bioRxiv : the preprint server for biology
information resource reference: Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance. bioRxiv. 2022 Dec 07.
journal title abbreviation: bioRxiv
publication date: 2022-12-07T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

The mRNA vaccine BNT162b2 demonstrates impaired TH1 immunogenicity in human elders in vitro and aged mice in vivo.
PubMed Identifier: 36597547
author list: Brook B, Fatou B, Kumar Checkervarty A, Barman S, Sweitzer C, Bosco AN, Sherman AC, Baden LR, Morrocchi E, Sanchez-Schmitz G, Palma P, Nanishi E, O'Meara TR, McGrath ME, Frieman MB, Soni D, van Haren SD, Ozonoff A, Diray-Arce J, Steen H, Dowling DJ, Levy O
published in: Research square
information resource reference: The mRNA vaccine BNT162b2 demonstrates impaired TH1 immunogenicity in human elders in vitro and aged mice in vivo. Res Sq. 2022 Dec 21.
journal title abbreviation: Res Sq
publication date: 2022-12-21T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1526468
type: Authorship
author rank in publication: 30
linked author: Dowling, David
linked information resource: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice.

Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice.
PubMed Identifier: 36788219
author list: Nanishi E, Borriello F, Seo HS, O'Meara TR, McGrath ME, Saito Y, Chen J, Diray-Arce J, Song K, Xu AZ, Barman S, Menon M, Dong D, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Baden LR, Ernst RK, Dillen C, Yu J, Chang A, Hilgers L, Platenburg PP, Dhe-Paganon S, Barouch DH, Ozonoff A, Zanoni I, Frieman MB, Dowling DJ, Levy O
published in: NPJ vaccines
information resource reference: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice. NPJ Vaccines. 2023 Feb 14; 8(1):18.
journal title abbreviation: NPJ Vaccines
publication date: 2023-02-14T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1528568
type: Authorship
author rank in publication: 30
linked author: Dowling, David
linked information resource: Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice.

Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice.
PubMed Identifier: 36869134
author list: Nanishi E, Borriello F, Seo HS, O'Meara TR, McGrath ME, Saito Y, Chen J, Diray-Arce J, Song K, Xu AZ, Barman S, Menon M, Dong D, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Baden LR, Ernst RK, Dillen C, Yu J, Chang A, Hilgers L, Platenburg PP, Dhe-Paganon S, Barouch DH, Ozonoff A, Zanoni I, Frieman MB, Dowling DJ, Levy O
published in: NPJ vaccines
information resource reference: Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice. NPJ Vaccines. 2023 Mar 03; 8(1):30.
journal title abbreviation: NPJ Vaccines
publication date: 2023-03-03T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Precision Vaccines
type: Division
type: Organization

Authorship 1572957
type: Authorship
author rank in publication: 4
linked author: Dowling, David
linked information resource: Precision Vaccinology Approaches for the Development of Adjuvanted Vaccines Targeted to Distinct Vulnerable Populations.

Authorship 1557212
type: Authorship
author rank in publication: 6
linked author: Dowling, David
linked information resource: A protocol for high-throughput screening for immunomodulatory compounds using human primary cells.

Precision Vaccinology Approaches for the Development of Adjuvanted Vaccines Targeted to Distinct Vulnerable Populations.
PubMed Identifier: 37376214
author list: Lee B, Nanishi E, Levy O, Dowling DJ
published in: Pharmaceutics
information resource reference: Precision Vaccinology Approaches for the Development of Adjuvanted Vaccines Targeted to Distinct Vulnerable Populations. Pharmaceutics. 2023 Jun 19; 15(6).
journal title abbreviation: Pharmaceutics
publication date: 2023-06-19T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

A protocol for high-throughput screening for immunomodulatory compounds using human primary cells.
PubMed Identifier: 37453068
author list: Chew K, Lee B, Ozonoff A, Smith JA, Levy O, Dowling DJ, Van Haren S
published in: STAR protocols
information resource reference: A protocol for high-throughput screening for immunomodulatory compounds using human primary cells. STAR Protoc. 2023 09 15; 4(3):102405.
journal title abbreviation: STAR Protoc
publication date: 2023-07-13T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1581909
type: Authorship
author rank in publication: 13
linked author: Dowling, David
linked information resource: Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.

Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.
PubMed Identifier: 37595760
author list: O'Meara TR, Nanishi E, McGrath ME, Barman S, Dong D, Dillen C, Menon M, Seo HS, Dhe-Paganon S, Ernst RK, Levy O, Frieman MB, Dowling DJ
published in: The Journal of allergy and clinical immunology
information resource reference: Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance. J Allergy Clin Immunol. 2023 11; 152(5):1107-1120.e6.
journal title abbreviation: J Allergy Clin Immunol
publication date: 2023-08-16T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Human in vitro modeling of adjuvant formulations demonstrates enhancement of immune responses to SARS-CoV-2 antigen.
PubMed Identifier: 37884538
author list: Doss-Gollin S, Thomas S, Brook B, Abedi K, Lebas C, Auderset F, Lugo-Rodriguez Y, Sanchez-Schmitz G, Dowling DJ, Levy O, van Haren SD
published in: NPJ vaccines
information resource reference: Human in vitro modeling of adjuvant formulations demonstrates enhancement of immune responses to SARS-CoV-2 antigen. NPJ Vaccines. 2023 Oct 26; 8(1):163.
journal title abbreviation: NPJ Vaccines
publication date: 2023-10-26T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1600955
type: Authorship
author rank in publication: 9
linked author: Dowling, David
linked information resource: Human in vitro modeling of adjuvant formulations demonstrates enhancement of immune responses to SARS-CoV-2 antigen.

Authorship 1599764
type: Authorship
author rank in publication: 14
linked author: Dowling, David
linked information resource: Adjuvant Discovery via a High Throughput Screen using Human Primary Mononuclear Cells.

Authorship 1659089
type: Authorship
author rank in publication: 8
linked author: Dowling, David
linked information resource: Immune profiling of age and adjuvant-specific activation of human blood mononuclear cells in vitro.

Immune profiling of age and adjuvant-specific activation of human blood mononuclear cells in vitro.
PubMed Identifier: 38851856
author list: Schüller SS, Barman S, Mendez-Giraldez R, Soni D, Daley J, Baden LR, Levy O, Dowling DJ
published in: Communications biology
information resource reference: Immune profiling of age and adjuvant-specific activation of human blood mononuclear cells in vitro. Commun Biol. 2024 06 08; 7(1):709.
journal title abbreviation: Commun Biol
publication date: 2024-06-08T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1664461
type: Authorship
author rank in publication: 25
linked author: Dowling, David
linked information resource: From hit to vial: Precision discovery and development of an imidazopyrimidine TLR7/8 agonist adjuvant formulation.

Authorship 1663570
type: Authorship
author rank in publication: 7
linked author: Dowling, David
linked information resource: BECC-engineered live-attenuated Shigella vaccine candidates display reduced endotoxicity with robust immunogenicity in mice.

From hit to vial: Precision discovery and development of an imidazopyrimidine TLR7/8 agonist adjuvant formulation.
PubMed Identifier: 38959314
author list: Soni D, Borriello F, Scott DA, Feru F, DeLeon M, Brightman SE, Cheng WK, Melhem G, Smith JA, Ramirez JC, Barman S, Cameron M, Kelly A, Walker K, Nanishi E, van Haren SD, Phan T, Qi Y, Kinsey R, Raczy MM, Ozonoff A, Pettengill MA, Hubbell JA, Fox CB, Dowling DJ, Levy O
published in: Science advances
information resource reference: From hit to vial: Precision discovery and development of an imidazopyrimidine TLR7/8 agonist adjuvant formulation. Sci Adv. 2024 07 05; 10(27):eadg3747.
journal title abbreviation: Sci Adv
publication date: 2024-07-03T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

BECC-engineered live-attenuated Shigella vaccine candidates display reduced endotoxicity with robust immunogenicity in mice.
PubMed Identifier: 38946947
author list: Sherman ME, Michalski J, Das S, Yang H, Chandrasekaran L, O'Meara TR, Dowling DJ, Levy O, Barnoy S, Venkatesan M, Ernst RK
published in: Research square
information resource reference: BECC-engineered live-attenuated Shigella vaccine candidates display reduced endotoxicity with robust immunogenicity in mice. Res Sq. 2024 Jun 11.
journal title abbreviation: Res Sq
publication date: 2024-06-11T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1665920
type: Authorship
author rank in publication: 6
linked author: Dowling, David
linked information resource: Need for strategic communications and stakeholder engagement to advance acceptability of an overdose preventing vaccine targeting fentanyl.

Need for strategic communications and stakeholder engagement to advance acceptability of an overdose preventing vaccine targeting fentanyl.
PubMed Identifier: 38991914
author list: Weitzman ER, Pierce SE, Blakemore LM, Murdock A, Angelidou A, Dowling DJ, Levy O, Levy S
published in: Vaccine
information resource reference: Need for strategic communications and stakeholder engagement to advance acceptability of an overdose preventing vaccine targeting fentanyl. Vaccine. 2024 10 24; 42(24):126082.
journal title abbreviation: Vaccine
publication date: 2024-07-10T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1669789
type: Authorship
author rank in publication: 17
linked author: Dowling, David
linked information resource: Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70.

Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70.
PubMed Identifier: 39047117
author list: Brook B, Duval V, Barman S, Speciner L, Sweitzer C, Khanmohammed A, Menon M, Foster K, Ghosh P, Abedi K, Koster J, Nanishi E, Baden LR, Levy O, VanCott T, Micol R, Dowling DJ
published in: Science translational medicine
information resource reference: Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70. Sci Transl Med. 2024 07 24; 16(757):eadm8451.
journal title abbreviation: Sci Transl Med
publication date: 2024-07-24T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Instructor in Neurology
is primary position: true
position in department: Neurology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Instructor in Neurology
position in organization: Massachusetts General Hospital

William Bosworth Castle Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Vaccine Research
sort order: 1
type: Position
HR job title: William Bosworth Castle Professor of Medicine
position in organization: Beth Israel Deaconess Medical Center

Authorship 1700735
type: Authorship
author rank in publication: 5
linked author: Dowling, David
linked information resource: Social complexity of a fentanyl vaccine to prevent opioid overdose conference proceedings: Radcliffe Institute for Advanced Study conference proceedings.

Social complexity of a fentanyl vaccine to prevent opioid overdose conference proceedings: Radcliffe Institute for Advanced Study conference proceedings.
PubMed Identifier: 39317618
author list: Weitzman ER, Alegria M, Caplan A, Dowling D, Evans J, Fisher CE, Jordan A, Kossowsky J, Landau M, Larson H, Levy O, Levy S, Mnookin S, Reif S, Ross J, Sherman AC
published in: Vaccine
information resource reference: Social complexity of a fentanyl vaccine to prevent opioid overdose conference proceedings: Radcliffe Institute for Advanced Study conference proceedings. Vaccine. 2025 01 12; 44:126324.
journal title abbreviation: Vaccine
publication date: 2024-09-23T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Elizabeth G. and Gary J. Nabel Family Professor Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Infectious Disease
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type: Position
HR job title: Elizabeth G. and Gary J. Nabel Family Professor Professor of Medicine
position in organization: Brigham and Women's Hospital

Authorship 1708392
type: Authorship
author rank in publication: 20
linked author: Dowling, David
linked information resource: The BNT162b2 mRNA vaccine demonstrates reduced age-associated TH1 support in vitro and in vivo.

The BNT162b2 mRNA vaccine demonstrates reduced age-associated TH1 support in vitro and in vivo.
PubMed Identifier: 39569372
author list: Brook B, Checkervarty AK, Barman S, Sweitzer C, Bosco AN, Sherman AC, Baden LR, Morrocchi E, Sanchez-Schmitz G, Palma P, Nanishi E, O'Meara TR, McGrath ME, Frieman MB, Soni D, van Haren SD, Ozonoff A, Diray-Arce J, Steen H, Dowling DJ, Levy O
published in: iScience
information resource reference: The BNT162b2 mRNA vaccine demonstrates reduced age-associated TH1 support in vitro and in vivo. iScience. 2024 Nov 15; 27(11):111055.
journal title abbreviation: iScience
publication date: 2024-09-26T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1711241
type: Authorship
author rank in publication: 5
linked author: Dowling, David
linked information resource: An ionic liquid-based adjuvant for modulating cellular and humoral immune responses.

An ionic liquid-based adjuvant for modulating cellular and humoral immune responses.
PubMed Identifier: 39437967
author list: Goetz MJ, Park KS, Joshi M, Gottlieb AP, Dowling DJ, Mitragotri S
published in: Journal of controlled release : official journal of the Controlled Release Society
information resource reference: An ionic liquid-based adjuvant for modulating cellular and humoral immune responses. J Control Release. 2024 Dec; 376:632-645.
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year: 2024
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Authorship 99773
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author rank in publication: 1
linked author: Dowling, David
linked information resource: Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses.

Protocol for measuring anti-fentanyl antibodies in mouse serum by enzyme-linked immunosorbent assay.
PubMed Identifier: 39645655
author list: Koster JA, Prevost-Reilly A, Soni D, Kelly A, Walker K, Norton EB, Levy O, Haile CN, Dowling DJ
published in: STAR protocols
information resource reference: Protocol for measuring anti-fentanyl antibodies in mouse serum by enzyme-linked immunosorbent assay. STAR Protoc. 2024 12 20; 5(4):103402.
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publication date: 2024-12-06T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
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Authorship 1715057
type: Authorship
author rank in publication: 9
linked author: Dowling, David
linked information resource: Protocol for measuring anti-fentanyl antibodies in mouse serum by enzyme-linked immunosorbent assay.

Authorship 1735655
type: Authorship
author rank in publication: 13
linked author: Dowling, David
linked information resource: Product and trial design considerations on the path towards a vaccine to combat opioid overdose.

Authorship 1729199
type: Authorship
author rank in publication: 7
linked author: Dowling, David
linked information resource: BECC-engineered live-attenuated Shigella vaccine candidates display reduced endotoxicity with robust immunogenicity in mice.

BECC-engineered live-attenuated Shigella vaccine candidates display reduced endotoxicity with robust immunogenicity in mice.
PubMed Identifier: 39946867
author list: Sherman ME, Michalski J, Das S, Yang H, Chandrasekaran L, O'Meara TR, Dowling DJ, Levy O, Barnoy S, Venkatesan M, Ernst RK
published in: Vaccine
information resource reference: BECC-engineered live-attenuated Shigella vaccine candidates display reduced endotoxicity with robust immunogenicity in mice. Vaccine. 2025 03 19; 50:126779.
journal title abbreviation: Vaccine
publication date: 2025-02-12T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Product and trial design considerations on the path towards a vaccine to combat opioid overdose.
PubMed Identifier: 39971929
author list: Angelidou A, Koster JA, Sherman AC, McLoughlin C, Lalwani P, Kelly A, Saeed A, McEnaney K, Baden LR, Brogna M, Weitzman ER, Levy S, Dowling DJ, Levy O
published in: NPJ vaccines
information resource reference: Product and trial design considerations on the path towards a vaccine to combat opioid overdose. NPJ Vaccines. 2025 Feb 19; 10(1):35.
journal title abbreviation: NPJ Vaccines
publication date: 2025-02-19T00:00:00
year: 2025
type: Academic Article
type: Article
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Authorship 1742565
type: Authorship
author rank in publication: 5
linked author: Dowling, David
linked information resource: mRNA vaccines: miRNA-based controlled biodistribution and directed adjuvantation.

Authorship 1750187
type: Authorship
author rank in publication: 9
linked author: Dowling, David
linked information resource: OMIP-111: Immune-Profiling of T Helper 1 (Th1), Th2, and Th17 Signatures in Murine Splenocytes by Targeting Intracellular Cytokines.

OMIP-111: Immune-Profiling of T Helper 1 (Th1), Th2, and Th17 Signatures in Murine Splenocytes by Targeting Intracellular Cytokines.
PubMed Identifier: 40095325
author list: Barman S, Kelly A, Dong D, Patel A, Buonopane MJ, Gonzales J, Janoschek B, Draghi A, Dowling DJ
published in: Cytometry. Part A : the journal of the International Society for Analytical Cytology
information resource reference: OMIP-111: Immune-Profiling of T Helper 1 (Th1), Th2, and Th17 Signatures in Murine Splenocytes by Targeting Intracellular Cytokines. Cytometry A. 2025 Apr; 107(4):221-225.
journal title abbreviation: Cytometry A
publication date: 2025-03-17T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

mRNA vaccines: miRNA-based controlled biodistribution and directed adjuvantation.
PubMed Identifier: 40268657
author list: Brook B, Goetz M, Duval V, Micol R, Dowling DJ
published in: Trends in immunology
information resource reference: mRNA vaccines: miRNA-based controlled biodistribution and directed adjuvantation. Trends Immunol. 2025 May; 46(5):357-360.
journal title abbreviation: Trends Immunol
publication date: 2025-04-22T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 389372
type: Authorship
author rank in publication: 1
linked author: Dowling, David
linked information resource: The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes.

Clinical Fellow in Medicine
is primary position: true
position in department: Medicine
position in division: Adm-House Staff
sort order: 1
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HR job title: Clinical Fellow in Medicine
position in organization: Beth Israel Deaconess Medical Center

Chew, Katherine
first name: Katherine
last name: Chew
full name: Katherine Chew, M.D.
has faculty rank: Fellow or Post Doc
Person ID: 225048
person in primary position: Clinical Fellow in Medicine
type: Agent
type: Person
preferred title: Clinical Fellow in Medicine

Discovery of a small molecule TLR3 agonist adjuvant.
PubMed Identifier: 41339634
author list: Lee B, Dong D, Nanishi E, Awad JM, Abedi KZ, Saito Y, Borriello F, Barman S, Brook B, Kelly A, Menon M, Marques-Mourlet C, Gupta MV, Lister I, Oh C, Lyskawa K, Goetz M, Walker K, Cheng WK, Brightman SE, Sharma P, O'Meara TR, Chew K, Vieira D, Ryff K, Sweitzer C, Thomas S, van Haren SD, Pettengill M, Seo HS, Dhe-Paganon S, Zhang W, Levy O, Dowling DJ
published in: Nature communications
information resource reference: Discovery of a small molecule TLR3 agonist adjuvant. Nat Commun. 2025 Dec 04; 17(1):364.
journal title abbreviation: Nat Commun
publication date: 2025-12-04T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1771583
type: Authorship
author rank in publication: 34
linked author: Dowling, David
linked information resource: Discovery of a small molecule TLR3 agonist adjuvant.

Authorship 1794056
type: Authorship
author rank in publication: 7
linked author: Dowling, David
linked information resource: Plant growth promotion induced by phosphate solubilizing endophytic Pseudomonas isolates.

Authorship 1804140
type: Authorship
author rank in publication: 3
linked author: Dowling, David
linked information resource: Protection of Pepper Plants from Drought by Microbacterium sp. 3J1 by Modulation of the Plant's Glutamine and a-ketoglutarate Content: A Comparative Metabolomics Approach.

Authorship 1816395
type: Authorship
author rank in publication: 3
linked author: Dowling, David
linked information resource: Incorporating meningeal immunity into vaccine development.

Authorship 1817148
type: Authorship
author rank in publication: 4
linked author: Dowling, David
linked information resource: Deep phenomics of PRR agonist activated human blood.

Authorship 1821676
type: Authorship
author rank in publication: 7
linked author: Dowling, David
linked information resource: Field scale biodegradation of total petroleum hydrocarbons and soil restoration by Ecopiles: microbiological analysis of the process.

Authorship 1838904
type: Authorship
author rank in publication: 2
linked author: Dowling, David
linked information resource: Crop Establishment Practices Are a Driver of the Plant Microbiota in Winter Oilseed Rape (Brassica napus).

Authorship 1845004
type: Authorship
author rank in publication: 6
linked author: Dowling, David
linked information resource: Nanomedicine and Spleen-Targeting Strategies for Precision Immunomodulation: Advances, Challenges, and Future Perspectives.

Protection of Pepper Plants from Drought by Microbacterium sp. 3J1 by Modulation of the Plant's Glutamine and a-ketoglutarate Content: A Comparative Metabolomics Approach.
PubMed Identifier: 29520258
author list: Vílchez JI, Niehaus K, Dowling DN, González-López J, Manzanera M
published in: Frontiers in microbiology
information resource reference: Protection of Pepper Plants from Drought by Microbacterium sp. 3J1 by Modulation of the Plant's Glutamine and a-ketoglutarate Content: A Comparative Metabolomics Approach. Front Microbiol. 2018; 9:284.
journal title abbreviation: Front Microbiol
publication date: 2018-02-22T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Field scale biodegradation of total petroleum hydrocarbons and soil restoration by Ecopiles: microbiological analysis of the process.
PubMed Identifier: 37152743
author list: Martínez-Cuesta R, Conlon R, Wang M, Blanco-Romero E, Durán D, Redondo-Nieto M, Dowling D, Garrido-Sanz D, Martin M, Germaine K, Rivilla R
published in: Frontiers in microbiology
information resource reference: Field scale biodegradation of total petroleum hydrocarbons and soil restoration by Ecopiles: microbiological analysis of the process. Front Microbiol. 2023; 14:1158130.
journal title abbreviation: Front Microbiol
publication date: 2023-04-21T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Nanomedicine and Spleen-Targeting Strategies for Precision Immunomodulation: Advances, Challenges, and Future Perspectives.
PubMed Identifier: 40576399
author list: Oh C, Jung HN, Park J, Awad JM, Jiang D, Dowling DJ, Im HJ
published in: ACS nano
information resource reference: Nanomedicine and Spleen-Targeting Strategies for Precision Immunomodulation: Advances, Challenges, and Future Perspectives. ACS Nano. 2025 Jul 08; 19(26):23491-23516.
journal title abbreviation: ACS Nano
publication date: 2025-06-27T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Deep phenomics of PRR agonist activated human blood.
PubMed Identifier: 41206680
author list: Barman S, Patel A, Kelly A, Dowling DJ
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Deep phenomics of PRR agonist activated human blood. J Immunol. 2025 Dec 01; 214(12):3294-3309.
journal title abbreviation: J Immunol
publication date: 2025-12-01T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Crop Establishment Practices Are a Driver of the Plant Microbiota in Winter Oilseed Rape (Brassica napus).
PubMed Identifier: 28848510
author list: Rathore R, Dowling DN, Forristal PD, Spink J, Cotter PD, Bulgarelli D, Germaine KJ
published in: Frontiers in microbiology
information resource reference: Crop Establishment Practices Are a Driver of the Plant Microbiota in Winter Oilseed Rape (Brassica napus). Front Microbiol. 2017; 8:1489.
journal title abbreviation: Front Microbiol
publication date: 2017-08-09T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Plant growth promotion induced by phosphate solubilizing endophytic Pseudomonas isolates.
PubMed Identifier: 26257721
author list: Oteino N, Lally RD, Kiwanuka S, Lloyd A, Ryan D, Germaine KJ, Dowling DN
published in: Frontiers in microbiology
information resource reference: Plant growth promotion induced by phosphate solubilizing endophytic Pseudomonas isolates. Front Microbiol. 2015; 6:745.
journal title abbreviation: Front Microbiol
publication date: 2015-07-22T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Incorporating meningeal immunity into vaccine development.
PubMed Identifier: 41068115
author list: Menon M, Haile CN, Dowling DJ
published in: Nature communications
information resource reference: Incorporating meningeal immunity into vaccine development. Nat Commun. 2025 Oct 09; 16(1):8981.
journal title abbreviation: Nat Commun
publication date: 2025-10-09T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Adolescent Medicine
type: Division
type: Organization

Gastroenterology & Nutrition
type: Division
type: Organization

Associate Professor of Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Gastroenterology & Nutrition
sort order: 1
type: Position
HR job title: Associate Professor of Pediatrics
position in organization: Boston Children's Hospital

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Infectious Disease
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Brigham and Women's Hospital

Instructor in Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Precision Vaccines
sort order: 1
type: Position
HR job title: Instructor in Pediatrics
position in organization: Boston Children's Hospital

Professor of Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Adolescent Medicine
sort order: 1
type: Position
HR job title: Professor of Pediatrics
position in organization: Boston Children's Hospital

Instructor in Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Precision Vaccines
sort order: 1
type: Position
HR job title: Instructor in Pediatrics
position in organization: Boston Children's Hospital

Professor of Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Precision Vaccines
sort order: 1
type: Position
HR job title: Professor of Pediatrics
position in organization: Boston Children's Hospital

Assistant Professor of Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Precision Vaccines
sort order: 1
type: Position
HR job title: Assistant Professor of Pediatrics
position in organization: Boston Children's Hospital

Research Associate in Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Precision Vaccines
sort order: 1
type: Position
HR job title: Research Associate in Pediatrics
position in organization: Boston Children's Hospital

Assistant Professor of Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Precision Vaccines
sort order: 1
type: Position
HR job title: Assistant Professor of Pediatrics
position in organization: Boston Children's Hospital

Assistant Professor of Pediatrics
is primary position: true
position in department: Pediatrics
position in division: Precision Vaccines
sort order: 1
type: Position
HR job title: Assistant Professor of Pediatrics
position in organization: Boston Children's Hospital

Authorship 744923
type: Authorship
author rank in publication: 1
linked author: Dowling, David
linked information resource: Ontogeny of early life immunity.

Authorship 744924
type: Authorship
author rank in publication: 7
linked author: Dowling, David
linked information resource: The effect of stable macromolecular complexes of ionic polyphosphazene on HIV Gag antigen and on activation of human dendritic cells and presentation to T-cells.

The effect of stable macromolecular complexes of ionic polyphosphazene on HIV Gag antigen and on activation of human dendritic cells and presentation to T-cells.
PubMed Identifier: 25023392
author list: Palmer CD, Ninkovic J, Prokopowicz ZM, Mancuso CJ, Marin A, Andrianov AK, Dowling DJ, Levy O
published in: Biomaterials
information resource reference: The effect of stable macromolecular complexes of ionic polyphosphazene on HIV Gag antigen and on activation of human dendritic cells and presentation to T-cells. Biomaterials. 2014 Oct; 35(31):8876-8886.
journal title abbreviation: Biomaterials
publication date: 2014-07-11T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Ontogeny of early life immunity.
PubMed Identifier: 24880460
author list: Dowling DJ, Levy O
published in: Trends in immunology
information resource reference: Ontogeny of early life immunity. Trends Immunol. 2014 Jul; 35(7):299-310.
journal title abbreviation: Trends Immunol
publication date: 2014-05-28T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 498195
type: Authorship
author rank in publication: 1
linked author: Dowling, David
linked information resource: A comparative analysis of cytokine responses, cell surface marker expression and MAPKs in DCs matured with LPS compared with a panel of TLR ligands.

Authorship 561065
type: Authorship
author rank in publication: 6
linked author: Dowling, David
linked information resource: The Sigma class glutathione transferase from the liver fluke Fasciola hepatica.

Authorship 2957
type: Authorship
author rank in publication: 2
linked author: Dowling, David
linked information resource: The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function.

Authorship 51542
type: Authorship
author rank in publication: 3
linked author: Dowling, David
linked information resource: The effects of Fasciola hepatica tegumental antigens on mast cell function.

Authorship 430882
type: Authorship
author rank in publication: 4
linked author: Dowling, David
linked information resource: Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica released by Nonidet P40.

Authorship 825444
type: Authorship
author rank in publication: 3
linked author: Dowling, David
linked information resource: The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes.

The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes.
PubMed Identifier: 26274907
author list: Ganapathi L, Van Haren S, Dowling DJ, Bergelson I, Shukla NM, Malladi SS, Balakrishna R, Tanji H, Ohto U, Shimizu T, David SA, Levy O
published in: PloS one
information resource reference: The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes. PLoS One. 2015; 10(8):e0134640.
journal title abbreviation: PLoS One
publication date: 2015-08-14T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 857569
type: Authorship
author rank in publication: 1
linked author: Dowling, David
linked information resource: Pediatric Vaccine Adjuvants: Components of the Modern Vaccinologist's Toolbox.

Pediatric Vaccine Adjuvants: Components of the Modern Vaccinologist's Toolbox.
PubMed Identifier: 26353029
author list: Dowling DJ, Levy O
published in: The Pediatric infectious disease journal
information resource reference: Pediatric Vaccine Adjuvants: Components of the Modern Vaccinologist's Toolbox. Pediatr Infect Dis J. 2015 Dec; 34(12):1395-8.
journal title abbreviation: Pediatr Infect Dis J
publication date: 2015-12-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 871459
type: Authorship
author rank in publication: 2
linked author: Dowling, David
linked information resource: Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures.

Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures.
PubMed Identifier: 26933193
author list: Oh DY, Dowling DJ, Ahmed S, Choi H, Brightman S, Bergelson I, Berger ST, Sauld JF, Pettengill M, Kho AT, Pollack HJ, Steen H, Levy O
published in: Molecular & cellular proteomics : MCP
information resource reference: Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures. Mol Cell Proteomics. 2016 06; 15(6):1877-94.
journal title abbreviation: Mol Cell Proteomics
publication date: 2016-03-01T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 879626
type: Authorship
author rank in publication: 4
linked author: Dowling, David
linked information resource: In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant.

In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant.
PubMed Identifier: 27081760
author list: van Haren SD, Ganapathi L, Bergelson I, Dowling DJ, Banks M, Samuels RC, Reed SG, Marshall JD, Levy O
published in: Cytokine
information resource reference: In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant. Cytokine. 2016 07; 83:99-109.
journal title abbreviation: Cytokine
publication date: 2016-04-12T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 887942
type: Authorship
author rank in publication: 1
linked author: Dowling, David
linked information resource: Early life immune ontogeny - understanding how we build and sustain immunity to infection.

Authorship 887943
type: Authorship
author rank in publication: 4
linked author: Dowling, David
linked information resource: Distinct TLR-mediated cytokine production and immunoglobulin secretion in human newborn naïve B cells.

Distinct TLR-mediated cytokine production and immunoglobulin secretion in human newborn naïve B cells.
PubMed Identifier: 27252169
author list: Pettengill MA, van Haren SD, Li N, Dowling DJ, Bergelson I, Jans J, Ferwerda G, Levy O
published in: Innate immunity
information resource reference: Distinct TLR-mediated cytokine production and immunoglobulin secretion in human newborn naïve B cells. Innate Immun. 2016 08; 22(6):433-43.
journal title abbreviation: Innate Immun
publication date: 2016-06-01T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Early life immune ontogeny - understanding how we build and sustain immunity to infection.
PubMed Identifier: 27354502
author list: Dowling DJ
published in: Perspectives in public health
information resource reference: Early life immune ontogeny - understanding how we build and sustain immunity to infection. Perspect Public Health. 2016 Jul; 136(4):205-7.
journal title abbreviation: Perspect Public Health
publication date: 2016-07-01T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Assistant Professor
sort order: 2
type: Faculty Rank

Associate Professor
sort order: 1
type: Faculty Rank

Fellow or Post Doc
sort order: 6
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Instructor
sort order: 4
type: Faculty Rank

Other Faculty
sort order: 5
type: Faculty Rank

Authorship 919132
type: Authorship
author rank in publication: 2
linked author: Dowling, David
linked information resource: Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization.

Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization.
PubMed Identifier: 27793997
author list: van Haren SD, Dowling DJ, Foppen W, Christensen D, Andersen P, Reed SG, Hershberg RM, Baden LR, Levy O
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization. J Immunol. 2016 12 01; 197(11):4413-4424.
journal title abbreviation: J Immunol
publication date: 2016-10-28T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 940591
type: Authorship
author rank in publication: 1
linked author: Dowling, David
linked information resource: A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity.

A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity.
PubMed Identifier: 28008331
author list: Dowling DJ, Sanders H, Cheng WK, Joshi S, Brightman S, Bergelson I, Pietrasanta C, van Haren SD, van Amsterdam S, Fernandez J, van den Dobbelsteen GP, Levy O
published in: Frontiers in immunology
information resource reference: A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity. Front Immunol. 2016; 7:562.
journal title abbreviation: Front Immunol
publication date: 2016-12-08T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 948410
type: Authorship
author rank in publication: 2
linked author: Dowling, David
linked information resource: Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns.

Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns.
PubMed Identifier: 28072760
author list: Speer EM, Dowling DJ, Ozog LS, Xu J, Yang J, Kennady G, Levy O
published in: Pediatric research
information resource reference: Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns. Pediatr Res. 2017 May; 81(5):806-816.
journal title abbreviation: Pediatr Res
publication date: 2017-01-10T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 973857
type: Authorship
author rank in publication: 1
linked author: Dowling, David
linked information resource: TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth.

Authorship 974152
type: Authorship
author rank in publication: 1
linked author: Dowling, David
linked information resource: Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses.

TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth.
PubMed Identifier: 28352660
author list: Dowling DJ, van Haren SD, Scheid A, Bergelson I, Kim D, Mancuso CJ, Foppen W, Ozonoff A, Fresh L, Theriot TB, Lackner AA, Fichorova RN, Smirnov D, Vasilakos JP, Beaurline JM, Tomai MA, Midkiff CC, Alvarez X, Blanchard JL, Gilbert MH, Aye PP, Levy O
published in: JCI insight
information resource reference: TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth. JCI Insight. 2017 03 23; 2(6):e91020.
journal title abbreviation: JCI Insight
publication date: 2017-03-23T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses.
PubMed Identifier: 28343701
author list: Dowling DJ, Scott EA, Scheid A, Bergelson I, Joshi S, Pietrasanta C, Brightman S, Sanchez-Schmitz G, Van Haren SD, Ninkovic J, Kats D, Guiducci C, de Titta A, Bonner DK, Hirosue S, Swartz MA, Hubbell JA, Levy O
published in: The Journal of allergy and clinical immunology
information resource reference: Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses. J Allergy Clin Immunol. 2017 Nov; 140(5):1339-1350.
journal title abbreviation: J Allergy Clin Immunol
publication date: 2017-03-23T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

300 Longwood Ave
type: Address
address line 1: Children's Hospital
address line 2: ID Enders 7
address line 3: 300 Longwood Ave
city: Boston
postal code: 02115
state or province: MA

Ascaris lumbricoides pseudocoelomic body fluid induces a partially activated dendritic cell phenotype with Th2 promoting ability in vivo.
PubMed Identifier: 20974144
author list: Dowling DJ, Noone CM, Adams PN, Vukman KV, Molloy SF, Forde J, Asaolu S, O'Neill SM
published in: International journal for parasitology
information resource reference: Ascaris lumbricoides pseudocoelomic body fluid induces a partially activated dendritic cell phenotype with Th2 promoting ability in vivo. Int J Parasitol. 2011 Feb; 41(2):255-61.
journal title abbreviation: Int J Parasitol
publication date: 2010-10-23T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum.
PubMed Identifier: 23294670
author list: Noone C, Parkinson M, Dowling DJ, Aldridge A, Kirwan P, Molloy SF, Asaolu SO, Holland C, O'Neill SM
published in: Malaria journal
information resource reference: Plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum. Malar J. 2013 Jan 07; 12:5.
journal title abbreviation: Malar J
publication date: 2013-01-07T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

A comparative analysis of cytokine responses, cell surface marker expression and MAPKs in DCs matured with LPS compared with a panel of TLR ligands.
PubMed Identifier: 18221884
author list: Dowling D, Hamilton CM, O'Neill SM
published in: Cytokine
information resource reference: A comparative analysis of cytokine responses, cell surface marker expression and MAPKs in DCs matured with LPS compared with a panel of TLR ligands. Cytokine. 2008 Mar; 41(3):254-62.
journal title abbreviation: Cytokine
publication date: 2008-01-24T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes.
PubMed Identifier: 23483986
author list: Dowling DJ, Tan Z, Prokopowicz ZM, Palmer CD, Matthews MA, Dietsch GN, Hershberg RM, Levy O
published in: PloS one
information resource reference: The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes. PLoS One. 2013; 8(3):e58164.
journal title abbreviation: PLoS One
publication date: 2013-03-04T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica released by Nonidet P40.
PubMed Identifier: 23021260
author list: Morphew RM, Hamilton CM, Wright HA, Dowling DJ, O'Neill SM, Brophy PM
published in: Veterinary parasitology
information resource reference: Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica released by Nonidet P40. Vet Parasitol. 2013 Jan 31; 191(3-4):379-85.
journal title abbreviation: Vet Parasitol
publication date: 2012-09-11T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1036819
type: Authorship
author rank in publication: 12
linked author: Dowling, David
linked information resource: Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization.

Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization.
PubMed Identifier: 29312305
author list: Borriello F, Pietrasanta C, Lai JCY, Walsh LM, Sharma P, O'Driscoll DN, Ramirez J, Brightman S, Pugni L, Mosca F, Burkhart DJ, Dowling DJ, Levy O
published in: Frontiers in immunology
information resource reference: Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization. Front Immunol. 2017; 8:1772.
journal title abbreviation: Front Immunol
publication date: 2017-12-12T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses.
PubMed Identifier: 19917714
author list: Dowling DJ, Hamilton CM, Donnelly S, La Course J, Brophy PM, Dalton J, O'Neill SM
published in: Infection and immunity
information resource reference: Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses. Infect Immun. 2010 Feb; 78(2):793-801.
journal title abbreviation: Infect Immun
publication date: 2009-11-16T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn.
PubMed Identifier: 29416539
author list: Scheid A, Borriello F, Pietrasanta C, Christou H, Diray-Arce J, Pettengill MA, Joshi S, Li N, Bergelson I, Kollmann T, Dowling DJ, Levy O
published in: Frontiers in immunology
information resource reference: Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn. Front Immunol. 2018; 9:29.
journal title abbreviation: Front Immunol
publication date: 2018-01-24T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource