Noseda R, Hernández A, Valladares L, Mondaca M, Laurido C, Soto-Moyano R
Melatonin-induced inhibition of spinal cord synaptic potentiation in rats is MT2 receptor-dependent. Neurosci Lett. 2004 Apr 22; 360(1-2):41-4.
Melatonin-induced inhibition of spinal cord synaptic potentiation in rats is MT2 receptor-dependent.
Noseda R, Constandil L, Bourgeais L, Chalus M, Villanueva L
The Journal of neuroscience : the official journal of the Society for Neuroscience
Changes of meningeal excitability mediated by corticotrigeminal networks: a link for the endogenous modulation of migraine pain. J Neurosci. 2010 Oct 27; 30(43):14420-9.
Changes of meningeal excitability mediated by corticotrigeminal networks: a link for the endogenous modulation of migraine pain.
Nir RR, Lee AJ, Huntington S, Noseda R, Bernstein CA, Fulton AB, Bertisch SM, Hovaguimian A, Buettner C, Borsook D, Burstein R
Color-selective photophobia in ictal vs interictal migraineurs and in healthy controls. Pain. 2018 Oct; 159(10):2030-2034.
Color-selective photophobia in ictal vs interictal migraineurs and in healthy controls.
Cephalalgia : an international journal of headache
Current understanding of photophobia, visual networks and headaches. Cephalalgia. 2019 11; 39(13):1623-1634.
Current understanding of photophobia, visual networks and headaches.
Zhang X, Levy D, Noseda R, Kainz V, Jakubowski M, Burstein R
Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci. 2010 Jun 30; 30(26):8807-14.
Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura.
Noseda R, Jakubowski M, Kainz V, Borsook D, Burstein R
Cortical projections of functionally identified thalamic trigeminovascular neurons: implications for migraine headache and its associated symptoms. J Neurosci. 2011 Oct 05; 31(40):14204-17.
Cortical projections of functionally identified thalamic trigeminovascular neurons: implications for migraine headache and its associated symptoms.
Younis S, Hougaard A, Noseda R, Ashina M
Current understanding of thalamic structure and function in migraine. Cephalalgia. 2019 11; 39(13):1675-1682.
Current understanding of thalamic structure and function in migraine.
Bernstein CA, Nir RR, Noseda R, Fulton AB, Huntington S, Lee AJ, Bertisch SM, Hovaguimian A, Buettner C, Borsook D, Burstein R
The migraine eye: distinct rod-driven retinal pathways' response to dim light challenges the visual cortex hyperexcitability theory. Pain. 2019 Mar; 160(3):569-578.
The migraine eye: distinct rod-driven retinal pathways' response to dim light challenges the visual cortex hyperexcitability theory.
Mondaca M, Hernández A, Valladares L, Sierralta W, Noseda R, Soto-Moyano R
Pharmacology, biochemistry, and behavior
Involvement of melatonin metabolites in the long-term inhibitory effect of the hormone on rat spinal nociceptive transmission. Pharmacol Biochem Behav. 2004 Feb; 77(2):275-9.
Involvement of melatonin metabolites in the long-term inhibitory effect of the hormone on rat spinal nociceptive transmission.
Levy D, Moskowitz MA, Noseda R, Burstein R
Activation of the migraine pain pathway by cortical spreading depression: do we need more evidence? Cephalalgia. 2012 May; 32(7):581-2.
Activation of the migraine pain pathway by cortical spreading depression: do we need more evidence?
Noseda R, Melo-Carrillo A, Nir RR, Strassman AM, Burstein R
Non-Trigeminal Nociceptive Innervation of the Posterior Dura: Implications to Occipital Headache. J Neurosci. 2019 03 06; 39(10):1867-1880.
Non-Trigeminal Nociceptive Innervation of the Posterior Dura: Implications to Occipital Headache.
Noseda R, Monconduit L, Constandil L, Chalus M, Villanueva L
Central nervous system networks involved in the processing of meningeal and cutaneous inputs from the ophthalmic branch of the trigeminal nerve in the rat. Cephalalgia. 2008 Aug; 28(8):813-24.
Central nervous system networks involved in the processing of meningeal and cutaneous inputs from the ophthalmic branch of the trigeminal nerve in the rat.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
Neurobiology of Photophobia. J Neuroophthalmol. 2019 03; 39(1):94-102.
Interdisciplinary Medicine and Biotechnology
Harvard T.H. Chan School of Public Health
John Hedley-Whyte Professor of Anaesthesia
Melo-Carrillo A, Strassman AM, Schain AJ, Noseda R, Ashina S, Adams A, Brin MF, Burstein R
Exploring the effects of extracranial injections of botulinum toxin type A on prolonged intracranial meningeal nociceptors responses to cortical spreading depression in female rats. Cephalalgia. 2019 10; 39(11):1358-1365.
Exploring the effects of extracranial injections of botulinum toxin type A on prolonged intracranial meningeal nociceptors responses to cortical spreading depression in female rats.
Noseda R, Schain AJ, Melo-Carrillo A, Tien J, Stratton J, Mai F, Strassman AM, Burstein R
Fluorescently-labeled fremanezumab is distributed to sensory and autonomic ganglia and the dura but not to the brain of rats with uncompromised blood brain barrier. Cephalalgia. 2020 03; 40(3):229-240.
Fluorescently-labeled fremanezumab is distributed to sensory and autonomic ganglia and the dura but not to the brain of rats with uncompromised blood brain barrier.
Frontiers in pain research (Lausanne, Switzerland)
Cerebro-Cerebellar Networks in Migraine Symptoms and Headache. Front Pain Res (Lausanne). 2022; 3:940923.
Cerebro-Cerebellar Networks in Migraine Symptoms and Headache.
European journal of pain (London, England)
Central generators of migraine and autonomic cephalalgias as targets for personalized pain management: Translational links. Eur J Pain. 2023 10; 27(9):1126-1138.
Central generators of migraine and autonomic cephalalgias as targets for personalized pain management: Translational links.
Robert C, Bourgeais L, Arreto CD, Condes-Lara M, Noseda R, Jay T, Villanueva L
Paraventricular hypothalamic regulation of trigeminovascular mechanisms involved in headaches. J Neurosci. 2013 May 15; 33(20):8827-40.
Paraventricular hypothalamic regulation of trigeminovascular mechanisms involved in headaches.
Unanswered questions in headache: so what is photophobia, anyway? Headache. 2013 Nov-Dec; 53(10):1679-80.
Unanswered questions in headache: so what is photophobia, anyway?
Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain. Pain. 2013 Dec; 154 Suppl 1:S44-53.
Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain.
Noseda R, Kainz V, Borsook D, Burstein R
Neurochemical pathways that converge on thalamic trigeminovascular neurons: potential substrate for modulation of migraine by sleep, food intake, stress and anxiety. PLoS One. 2014; 9(8):e103929.
Neurochemical pathways that converge on thalamic trigeminovascular neurons: potential substrate for modulation of migraine by sleep, food intake, stress and anxiety.
Hypothalamic and basal ganglia projections to the posterior thalamus: possible role in modulation of migraine headache and photophobia. Neuroscience. 2013 Sep 17; 248:359-68.
Hypothalamic and basal ganglia projections to the posterior thalamus: possible role in modulation of migraine headache and photophobia.
Migraine: multiple processes, complex pathophysiology. J Neurosci. 2015 Apr 29; 35(17):6619-29.
Migraine: multiple processes, complex pathophysiology.
Noseda R, Bernstein CA, Nir RR, Lee AJ, Fulton AB, Bertisch SM, Hovaguimian A, Cestari DM, Saavedra-Walker R, Borsook D, Doran BL, Buettner C, Burstein R
Migraine photophobia originating in cone-driven retinal pathways. Brain. 2016 07; 139(Pt 7):1971-86.
Migraine photophobia originating in cone-driven retinal pathways.
Hodkinson DJ, Wilcox SL, Veggeberg R, Noseda R, Burstein R, Borsook D, Becerra L
Increased Amplitude of Thalamocortical Low-Frequency Oscillations in Patients with Migraine. J Neurosci. 2016 07 27; 36(30):8026-36.
Increased Amplitude of Thalamocortical Low-Frequency Oscillations in Patients with Migraine.
Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, CSD, sensitization and modulation of pain. Pain. 2013 Dec; 154 Suppl 1.
Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, CSD, sensitization and modulation of pain.
Neuropeptides and Neurotransmitters That Modulate Thalamo-Cortical Pathways Relevant to Migraine Headache. Headache. 2017 May; 57 Suppl 2:97-111.
Neuropeptides and Neurotransmitters That Modulate Thalamo-Cortical Pathways Relevant to Migraine Headache.
Melo-Carrillo A, Noseda R, Nir RR, Schain AJ, Stratton J, Strassman AM, Burstein R
Selective Inhibition of Trigeminovascular Neurons by Fremanezumab: A Humanized Monoclonal Anti-CGRP Antibody. J Neurosci. 2017 07 26; 37(30):7149-7163.
Selective Inhibition of Trigeminovascular Neurons by Fremanezumab: A Humanized Monoclonal Anti-CGRP Antibody.
Noseda R, Lee AJ, Nir RR, Bernstein CA, Kainz VM, Bertisch SM, Buettner C, Borsook D, Burstein R
Proceedings of the National Academy of Sciences of the United States of America
Neural mechanism for hypothalamic-mediated autonomic responses to light during migraine. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):E5683-E5692.
Neural mechanism for hypothalamic-mediated autonomic responses to light during migraine.
Advances in understanding the mechanisms of migraine-type photophobia. Curr Opin Neurol. 2011 Jun; 24(3):197-202.
Advances in understanding the mechanisms of migraine-type photophobia.
Noseda R, Kainz V, Jakubowski M, Gooley JJ, Saper CB, Digre K, Burstein R
A neural mechanism for exacerbation of headache by light. Nat Neurosci. 2010 Feb; 13(2):239-45.
A neural mechanism for exacerbation of headache by light.
Zhang X, Levy D, Kainz V, Noseda R, Jakubowski M, Burstein R
Activation of central trigeminovascular neurons by cortical spreading depression. Ann Neurol. 2011 May; 69(5):855-65.
Activation of central trigeminovascular neurons by cortical spreading depression.
Melo-Carrillo A, Strassman AM, Nir RR, Schain AJ, Noseda R, Stratton J, Burstein R
Fremanezumab-A Humanized Monoclonal Anti-CGRP Antibody-Inhibits Thinly Myelinated (Ad) But Not Unmyelinated (C) Meningeal Nociceptors. J Neurosci. 2017 11 01; 37(44):10587-10596.
Fremanezumab-A Humanized Monoclonal Anti-CGRP Antibody-Inhibits Thinly Myelinated (Ad) But Not Unmyelinated (C) Meningeal Nociceptors.