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Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol. Proc Natl Acad Sci U S A. 1984 Apr; 81(7):2117-21.
Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.
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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med. 2008 Dec; 14(12):1351-6.
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.
Vander Heiden MG, Cantley LC, Thompson CB
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009 May 22; 324(5930):1029-33.
Understanding the Warburg effect: the metabolic requirements of cell proliferation.
Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange. J Biol Chem. 1984 Jun 10; 259(11):7056-60.
Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange.
Evidence that inhibitors of anion exchange induce a transmembrane conformational change in band 3. J Biol Chem. 1983 Feb 10; 258(3):1785-92.
Evidence that inhibitors of anion exchange induce a transmembrane conformational change in band 3.
Vanadium stimulates the (Na+,K+) pump in friend erythroleukemia cells and blocks erythropoiesis. J Cell Biol. 1983 Oct; 97(4):1299-302.
Vanadium stimulates the (Na+,K+) pump in friend erythroleukemia cells and blocks erythropoiesis.
The (Na,K)-ATPase of Friend erythroleukemia cells is phosphorylated near the ATP hydrolysis by an endogenous membrane-bound kinase. J Biol Chem. 1984 Apr 10; 259(7):4089-95.
The (Na,K)-ATPase of Friend erythroleukemia cells is phosphorylated near the ATP hydrolysis by an endogenous membrane-bound kinase.
Type 2 phosphatidylinositol 4-kinase is recruited to CD4 in response to CD4 cross-linking. Biochim Biophys Acta. 1995 Apr 27; 1248(2):129-34.
Type 2 phosphatidylinositol 4-kinase is recruited to CD4 in response to CD4 cross-linking.
Signal transduction and membrane traffic: the PITP/phosphoinositide connection. Cell. 1995 Jun 02; 81(5):659-62.
Signal transduction and membrane traffic: the PITP/phosphoinositide connection.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP
Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A. 2004 Aug 17; 101(33):12130-5.
Large-scale characterization of HeLa cell nuclear phosphoproteins.
Yuan H, Luo J, Field S, Weissleder R, Cantley L, Josephson L
Synthesis and activity of C11-modified wortmannin probes for PI3 kinase. Bioconjug Chem. 2005 May-Jun; 16(3):669-75.
Synthesis and activity of C11-modified wortmannin probes for PI3 kinase.
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Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia. Cell Metab. 2006 May; 3(5):355-66.
Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia.
Asara JM, Christofk HR, Freimark LM, Cantley LC
A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen. Proteomics. 2008 Mar; 8(5):994-9.
A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen.
Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength. J Biol Chem. 1997 Oct 31; 272(44):27665-70.
Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength.
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PI3K enters beta-testing. Cell Metab. 2008 Sep; 8(3):179-81.
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology
PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer. J Clin Oncol. 2009 Mar 20; 27(9):1477-84.
PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer.
Hutti JE, Shen RR, Abbott DW, Zhou AY, Sprott KM, Asara JM, Hahn WC, Cantley LC
Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation. Mol Cell. 2009 May 14; 34(4):461-72.
Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.
Tsou P, Zheng B, Hsu CH, Sasaki AT, Cantley LC
A fluorescent reporter of AMPK activity and cellular energy stress. Cell Metab. 2011 Apr 06; 13(4):476-486.
A fluorescent reporter of AMPK activity and cellular energy stress.
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Role of mitochondrial membrane potential in the regulation of murine erythroleukemia cell differentiation.
Mechanism of anion exchange across the red cell membrane by band 3: interactions between stilbenedisulfonate and NAP-taurine binding sites. Biochemistry. 1981 Sep 29; 20(20):5695-701.
Mechanism of anion exchange across the red cell membrane by band 3: interactions between stilbenedisulfonate and NAP-taurine binding sites.
Kanakaraj P, Duckworth B, Azzoni L, Kamoun M, Cantley LC, Perussia B
Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA-ligand interaction. J Exp Med. 1994 Feb 01; 179(2):551-8.
Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA-ligand interaction.
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Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins.
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Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science. 1999 Sep 24; 285(5436):2129-33.
Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.
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Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly. Curr Biol. 2000 Feb 10; 10(3):153-6.
Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly.
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Kinetic analysis of guanosine 5'-O-(3-thiotriphosphate) effects on phosphatidylinositol turnover in NRK cell homogenates.
Activation of beef heart mitochondrial adenosine triphosphatase by 2,4-dinitrophenol. Biochemistry. 1973 Nov 20; 12(24):4900-4.
Activation of beef heart mitochondrial adenosine triphosphatase by 2,4-dinitrophenol.
Characterization of the ATP-dependent proton pump of clathrin-coated vesicles. J Biol Chem. 1984 Jul 10; 259(13):8101-5.
Characterization of the ATP-dependent proton pump of clathrin-coated vesicles.
Toker A, Bachelot C, Chen CS, Falck JR, Hartwig JH, Cantley LC, Kovacsovics TJ
Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase. J Biol Chem. 1995 Dec 08; 270(49):29525-31.
Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase.
Kapeller R, Toker A, Cantley LC, Carpenter CL
Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin. J Biol Chem. 1995 Oct 27; 270(43):25985-91.
Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin.
Liu X, Brodeur SR, Gish G, Songyang Z, Cantley LC, Laudano AP, Pawson T
Regulation of c-Src tyrosine kinase activity by the Src SH2 domain. Oncogene. 1993 May; 8(5):1119-26.
Regulation of c-Src tyrosine kinase activity by the Src SH2 domain.
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Phosphoinositide 3-kinase in immunological systems.
Woolsey AM, Sunwoo L, Petersen CA, Brachmann SM, Cantley LC, Burleigh BA
Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation. J Cell Sci. 2003 Sep 01; 116(Pt 17):3611-22.
Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation.
Fernandes N, Sun Y, Chen S, Paul P, Shaw RJ, Cantley LC, Price BD
DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM. J Biol Chem. 2005 Apr 15; 280(15):15158-64.
DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.
Increasing the intracellular Na+ concentration induces differentiation in a pre-B lymphocyte cell line. Proc Natl Acad Sci U S A. 1983 Dec; 80(24):7547-50.
Increasing the intracellular Na+ concentration induces differentiation in a pre-B lymphocyte cell line.
Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol Cell Biol. 1994 Apr; 14(4):2777-85.
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.
Carraway KL, Soltoff SP, Diamonti AJ, Cantley LC
Heregulin stimulates mitogenesis and phosphatidylinositol 3-kinase in mouse fibroblasts transfected with erbB2/neu and erbB3. J Biol Chem. 1995 Mar 31; 270(13):7111-6.
Heregulin stimulates mitogenesis and phosphatidylinositol 3-kinase in mouse fibroblasts transfected with erbB2/neu and erbB3.
Prasad KV, Janssen O, Kapeller R, Raab M, Cantley LC, Rudd CE
Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells. Proc Natl Acad Sci U S A. 1993 Aug 01; 90(15):7366-70.
Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.
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Structural changes in (Na+ + K+)-ATPase accompanying detergent inactivation.
Songyang Z, Carraway KL, Eck MJ, Harrison SC, Feldman RA, Mohammadi M, Schlessinger J, Hubbard SR, Smith DP, Eng C
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Catalytic specificity of protein-tyrosine kinases is critical for selective signalling.
A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling. Cell. 1994 Jul 15; 78(1):5-8.
A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling.
Kapeller R, Prasad KV, Janssen O, Hou W, Schaffhausen BS, Rudd CE, Cantley LC
Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase. J Biol Chem. 1994 Jan 21; 269(3):1927-33.
Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase.
Biochemistry. PI3K charges ahead. Science. 2007 Jul 13; 317(5835):206-7.
Mitogens and ion fluxes. Annu Rev Physiol. 1988; 50:207-23.
Whitman M, Kaplan D, Roberts T, Cantley L
Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation. Biochem J. 1987 Oct 01; 247(1):165-74.
Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation.
Shyh-Chang N, Locasale JW, Lyssiotis CA, Zheng Y, Teo RY, Ratanasirintrawoot S, Zhang J, Onder T, Unternaehrer JJ, Zhu H, Asara JM, Daley GQ, Cantley LC
Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science. 2013 Jan 11; 339(6116):222-6.
Influence of threonine metabolism on S-adenosylmethionine and histone methylation.
Carpenter CL, Auger KR, Chanudhuri M, Yoakim M, Schaffhausen B, Shoelson S, Cantley LC
Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit. J Biol Chem. 1993 May 05; 268(13):9478-83.
Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit.
Characterization of nucleotide binding sites on chloroplast coupling factor 1. Biochemistry. 1975 Jul; 14(13):2968-75.
Characterization of nucleotide binding sites on chloroplast coupling factor 1.
Panchamoorthy G, Fukazawa T, Miyake S, Soltoff S, Reedquist K, Druker B, Shoelson S, Cantley L, Band H
p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase. J Biol Chem. 1996 Feb 09; 271(6):3187-94.
p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase.
Osborne MA, Zenner G, Lubinus M, Zhang X, Songyang Z, Cantley LC, Majerus P, Burn P, Kochan JP
The inositol 5'-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation. J Biol Chem. 1996 Nov 15; 271(46):29271-8.
The inositol 5'-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation.
Phosphoinositide binding domains: embracing 3-phosphate. Cell. 1999 Jun 25; 97(7):817-20.
Phosphoinositide binding domains: embracing 3-phosphate.
Fruman DA, Snapper SB, Yballe CM, Alt FW, Cantley LC
Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation. Biochem Soc Trans. 1999 Aug; 27(4):624-9.
Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation.
Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries. Methods Enzymol. 2000; 328:157-70.
Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries.
Kanai F, Liu H, Field SJ, Akbary H, Matsuo T, Brown GE, Cantley LC, Yaffe MB
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nat Cell Biol. 2001 Jul; 3(7):675-8.
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K.
Ueki K, Yballe CM, Brachmann SM, Vicent D, Watt JM, Kahn CR, Cantley LC
Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):419-24.
Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase.
Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff S
Oncogenes and signal transduction. Cell. 1991 Jan 25; 64(2):281-302.
Williamson AL, Lecchi P, Turk BE, Choe Y, Hotez PJ, McKerrow JH, Cantley LC, Sajid M, Craik CS, Loukas A
A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. J Biol Chem. 2004 Aug 20; 279(34):35950-7.
A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms.
The negative regulation of phosphoinositide 3-kinase signaling by p85 and it's implication in cancer. Cell Cycle. 2005 Oct; 4(10):1309-12.
The negative regulation of phosphoinositide 3-kinase signaling by p85 and it's implication in cancer.
Isakoff SJ, Engelman JA, Irie HY, Luo J, Brachmann SM, Pearline RV, Cantley LC, Brugge JS
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res. 2005 Dec 01; 65(23):10992-1000.
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells.
Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol. 2006 Feb; 4(2):e38.
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.
Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, Lindeman N, Gale CM, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, Cappuzzo F, Mok T, Lee C, Johnson BE, Cantley LC, Jänne PA
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007 May 18; 316(5827):1039-43.
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.
Quayle SN, Lee JY, Cheung LW, Ding L, Wiedemeyer R, Dewan RW, Huang-Hobbs E, Zhuang L, Wilson RK, Ligon KL, Mills GB, Cantley LC, Chin L
Somatic mutations of PIK3R1 promote gliomagenesis. PLoS One. 2012; 7(11):e49466.
Somatic mutations of PIK3R1 promote gliomagenesis.
Emerling BM, Benes CH, Poulogiannis G, Bell EL, Courtney K, Liu H, Choo-Wing R, Bellinger G, Tsukazawa KS, Brown V, Signoretti S, Soltoff SP, Cantley LC
Identification of CDCP1 as a hypoxia-inducible factor 2a (HIF-2a) target gene that is associated with survival in clear cell renal cell carcinoma patients. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3483-8.
Identification of CDCP1 as a hypoxia-inducible factor 2a (HIF-2a) target gene that is associated with survival in clear cell renal cell carcinoma patients.
Hypothalamic sodium-transport inhibitor is a high-affinity reversible inhibitor of Na+-K+-ATPase. Am J Physiol. 1984 Dec; 247(6 Pt 2):F919-24.
Hypothalamic sodium-transport inhibitor is a high-affinity reversible inhibitor of Na+-K+-ATPase.
Inositol 1,4,5-trisphosphate stimulates phosphorylation of a 62,000-dalton protein in monkey fibroblast and bovine brain cell lysates. J Biol Chem. 1984 Nov 25; 259(22):13652-5.
Inositol 1,4,5-trisphosphate stimulates phosphorylation of a 62,000-dalton protein in monkey fibroblast and bovine brain cell lysates.
Amiloride inhibits murine erythroleukemia cell differentiation: evidence for a Ca2+ requirement for commitment. Proc Natl Acad Sci U S A. 1980 Oct; 77(10):5948-52.
Amiloride inhibits murine erythroleukemia cell differentiation: evidence for a Ca2+ requirement for commitment.
Smith RL, Macara IG, Levenson R, Housman D, Cantley L
Evidence that a Na+/Ca2+ antiport system regulates murine erythroleukemia cell differentiation. J Biol Chem. 1982 Jan 25; 257(2):773-80.
Evidence that a Na+/Ca2+ antiport system regulates murine erythroleukemia cell differentiation.
Songyang Z, Blechner S, Hoagland N, Hoekstra MF, Piwnica-Worms H, Cantley LC
Use of an oriented peptide library to determine the optimal substrates of protein kinases. Curr Biol. 1994 Nov 01; 4(11):973-82.
Use of an oriented peptide library to determine the optimal substrates of protein kinases.
Jhun BH, Rose DW, Seely BL, Rameh L, Cantley L, Saltiel AR, Olefsky JM
Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression. Mol Cell Biol. 1994 Nov; 14(11):7466-75.
Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression.
Liscovitch M, Chalifa V, Pertile P, Chen CS, Cantley LC
Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D. J Biol Chem. 1994 Aug 26; 269(34):21403-6.
Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D.
Kapeller R, Chakrabarti R, Cantley L, Fay F, Corvera S
Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeleton. Mol Cell Biol. 1993 Oct; 13(10):6052-63.
Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeleton.
Phosphotransferases (Alcohol Group Acceptor)
Harvard T.H. Chan School of Public Health
Barry R. and Irene T. Bloom Professorship of Public Health
Panagiotis Konstantinopoulos, M.D., Ph.D.
Associate Professor of Radiation Oncology
Gregor Mendel Professor of Genetics and of Medicine
Matthew George Vander Heiden, M.D., Ph.D.
James Stillman Professor of Developmental Biology
Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, Blenis J
The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 2013 May 09; 153(4):840-54.
The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.
Role of Phosphoinositides and Protein Kinases in the control of Cancer Metabolism
MECHANISM OF CATION TRANSPORT REGULATION
Characterization of Phosphatidylinositol Kinases
Center on the Physics of Cancer Metabolism
FUNCTION OF THE ATAXIA TELANGIECTASIA GENE PRODUCT
STRUCTURE AND MECHANISM OF MEMBRANE TRANSPORT SYSTEMS
PHOSPHATDYLINOSITOL-3-P AND GROWTH REGULATION
Cheung LW, Hennessy BT, Li J, Yu S, Myers AP, Djordjevic B, Lu Y, Stemke-Hale K, Dyer MD, Zhang F, Ju Z, Cantley LC, Scherer SE, Liang H, Lu KH, Broaddus RR, Mills GB
High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cancer Discov. 2011 Jul; 1(2):170-85.
High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.
Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations. Curr Biol. 2011 Feb 08; 21(3):173-83.
Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations.
Gallop JL, Walrant A, Cantley LC, Kirschner MW
Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9. Proc Natl Acad Sci U S A. 2013 Apr 30; 110(18):7193-8.
Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9.
Targeting a common collaborator in cancer development. Sci Transl Med. 2010 Sep 08; 2(48):48ps45.
Targeting a common collaborator in cancer development.
Stem cell metabolism in tissue development and aging. Development. 2013 Jun; 140(12):2535-47.
Stem cell metabolism in tissue development and aging.
Song SJ, Poliseno L, Song MS, Ala U, Webster K, Ng C, Beringer G, Brikbak NJ, Yuan X, Cantley LC, Richardson AL, Pandolfi PP
MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling. Cell. 2013 Jul 18; 154(2):311-324.
MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling.
Lunardi A, Ala U, Epping MT, Salmena L, Clohessy JG, Webster KA, Wang G, Mazzucchelli R, Bianconi M, Stack EC, Lis R, Patnaik A, Cantley LC, Bubley G, Cordon-Cardo C, Gerald WL, Montironi R, Signoretti S, Loda M, Nardella C, Pandolfi PP
A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer. Nat Genet. 2013 Jul; 45(7):747-55.
A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.
Wang XS, Shankar S, Dhanasekaran SM, Ateeq B, Sasaki AT, Jing X, Robinson D, Cao Q, Prensner JR, Yocum AK, Wang R, Fries DF, Han B, Asangani IA, Cao X, Li Y, Omenn GS, Pflueger D, Gopalan A, Reuter VE, Kahoud ER, Cantley LC, Rubin MA, Palanisamy N, Varambally S, Chinnaiyan AM
Characterization of KRAS rearrangements in metastatic prostate cancer. Cancer Discov. 2011 Jun; 1(1):35-43.
Characterization of KRAS rearrangements in metastatic prostate cancer.
Comb WC, Hutti JE, Cogswell P, Cantley LC, Baldwin AS
p85a SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation. Mol Cell. 2012 Mar 30; 45(6):719-30.
p85a SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation.
Amato S, Liu X, Zheng B, Cantley L, Rakic P, Man HY
AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization. Science. 2011 Apr 08; 332(6026):247-51.
AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization.
Marinis JM, Hutti JE, Homer CR, Cobb BA, Cantley LC, McDonald C, Abbott DW
I?B kinase a phosphorylation of TRAF4 downregulates innate immune signaling. Mol Cell Biol. 2012 Jul; 32(13):2479-89.
I?B kinase a phosphorylation of TRAF4 downregulates innate immune signaling.
Current topics in microbiology and immunology
Introduction. Curr Top Microbiol Immunol. 2010; 346:1-7.
Shen CH, Yuan P, Perez-Lorenzo R, Zhang Y, Lee SX, Ou Y, Asara JM, Cantley LC, Zheng B
Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation. Mol Cell. 2013 Oct 24; 52(2):161-72.
Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation.
Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC
Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell. 2013 Nov 07; 155(4):844-57.
Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.
Shyh-Chang N, Zhu H, Yvanka de Soysa T, Shinoda G, Seligson MT, Tsanov KM, Nguyen L, Asara JM, Cantley LC, Daley GQ
Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell. 2013 Nov 07; 155(4):778-92.
Lin28 enhances tissue repair by reprogramming cellular metabolism.
What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway. Cancer Discov. 2013 Dec; 3(12):1345-54.
What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway.
The Role of PTEN and the PI3K Pathway in Prostate Cancer
SCOR IN MOLECULAR MEDICINE AND ATHEROSCLEROSIS
Klinghoffer RA, Duckworth B, Valius M, Cantley L, Kazlauskas A
Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity. Mol Cell Biol. 1996 Oct; 16(10):5905-14.
Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity.
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