Cantley, Lewis
eCommons Login: LCC1
first name: Lewis
last name: Cantley
coauthor of: Asara, John
coauthor of: Manning, Brendan
coauthor of: Vander Heiden, Matthew
coauthor of: Yaffe, Michael
coauthor of: Kahn, C.
full name: Lewis C. Cantley, Ph.D.
has faculty rank: Full Professor
has network: selected publications
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latitude: 42.34022770000000
longitude: -71.10585400000000
Person ID: 51151
person in primary position: Professor of Cell Biology
physical neighbor: Konstantinopoulos, Panagiotis
physical neighbor: Schlechter, Benjamin
physical neighbor: Slater, Sarah
physical neighbor: Stevenson, Mary
physical neighbor: Yurgelun, Matthew
similar to: Kahn, C.
similar to: Gygi, Steven
similar to: Toker, Alex
similar to: Perrimon, Norbert
similar to: Elledge, Stephen
type: Agent
type: Person
selected publications: Authorship 697661
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Characterization of sulfhydryl groups on chloroplast coupling factor 1 exposed by heat activation.
PubMed Identifier: 129152
author list: Cantley LC, Hammes GG
published in: Biochemistry
information resource reference: Characterization of sulfhydryl groups on chloroplast coupling factor 1 exposed by heat activation. Biochemistry. 1976 Jan 13; 15(1):9-14.
journal title abbreviation: Biochemistry
publication date: 1976-01-13T00:00:00
year: 1976
type: Academic Article
type: Article
type: Document
type: Information Resource

A slow interconversion between active and inactive states of the (Na-K)ATPase.
PubMed Identifier: 136980
author list: Cantley LC, Josephson L
published in: Biochemistry
information resource reference: A slow interconversion between active and inactive states of the (Na-K)ATPase. Biochemistry. 1976 Nov 30; 15(24):5280-7.
journal title abbreviation: Biochemistry
publication date: 1976-11-30T00:00:00
year: 1976
type: Academic Article
type: Article
type: Document
type: Information Resource

A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.
PubMed Identifier: 10829070
author list: Satterthwaite AB, Willis F, Kanchanastit P, Fruman D, Cantley LC, Helgason CD, Humphries RK, Lowell CA, Simon M, Leitges M, Tarakhovsky A, Tedder TF, Lesche R, Wu H, Witte ON
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6687-92.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2000-06-06T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins.
PubMed Identifier: 11118213
author list: Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, Hisaminato A, Fujiwara T, Ito Y, Cantley LC, Yaffe MB
published in: The EMBO journal
information resource reference: TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J. 2000 Dec 15; 19(24):6778-91.
journal title abbreviation: EMBO J
publication date: 2000-12-15T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 100859
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling.

Phosphorylation by LAMMER protein kinases: determination of a consensus site, identification of in vitro substrates, and implications for substrate preferences.
PubMed Identifier: 11827553
author list: Nikolakaki E, Du C, Lai J, Giannakouros T, Cantley L, Rabinow L
published in: Biochemistry
information resource reference: Phosphorylation by LAMMER protein kinases: determination of a consensus site, identification of in vitro substrates, and implications for substrate preferences. Biochemistry. 2002 Feb 12; 41(6):2055-66.
journal title abbreviation: Biochemistry
publication date: 2002-02-12T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.
PubMed Identifier: 10200246
author list: Cantley LC, Neel BG
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A. 1999 Apr 13; 96(8):4240-5.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1999-04-13T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding.
PubMed Identifier: 10488331
author list: Rittinger K, Budman J, Xu J, Volinia S, Cantley LC, Smerdon SJ, Gamblin SJ, Yaffe MB
published in: Molecular cell
information resource reference: Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding. Mol Cell. 1999 Aug; 4(2):153-66.
journal title abbreviation: Mol Cell
publication date: 1999-08-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha.
PubMed Identifier: 11062485
author list: Fruman DA, Mauvais-Jarvis F, Pollard DA, Yballe CM, Brazil D, Bronson RT, Kahn CR, Cantley LC
published in: Nature genetics
information resource reference: Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha. Nat Genet. 2000 Nov; 26(3):379-82.
journal title abbreviation: Nat Genet
publication date: 2000-11-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.
PubMed Identifier: 12906785
author list: Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J
published in: Current biology : CB
information resource reference: Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol. 2003 Aug 05; 13(15):1259-68.
journal title abbreviation: Curr Biol
publication date: 2003-08-05T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes.
PubMed Identifier: 3874870
author list: Rosoff PM, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes. J Biol Chem. 1985 Aug 05; 260(16):9209-15.
journal title abbreviation: J Biol Chem
publication date: 1985-08-05T00:00:00
year: 1985
type: Academic Article
type: Article
type: Document
type: Information Resource

Specificity in recognition of phosphopeptides by src-homology 2 domains.
PubMed Identifier: 7533766
author list: Cantley LC, Songyang Z
published in: Journal of cell science. Supplement
information resource reference: Specificity in recognition of phosphopeptides by src-homology 2 domains. J Cell Sci Suppl. 1994; 18:121-6.
journal title abbreviation: J Cell Sci Suppl
publication date: 1994-01-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

SH2 domains recognize specific phosphopeptide sequences.
PubMed Identifier: 7680959
author list: Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ
published in: Cell
information resource reference: SH2 domains recognize specific phosphopeptide sequences. Cell. 1993 Mar 12; 72(5):767-78.
journal title abbreviation: Cell
publication date: 1993-03-12T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

A characterization of vanadate interactions with the (Na,K)-ATPase. Mechanistic and regulatory implications.
PubMed Identifier: 212422
author list: Cantley LC, Cantley LG, Josephson L
published in: The Journal of biological chemistry
information resource reference: A characterization of vanadate interactions with the (Na,K)-ATPase. Mechanistic and regulatory implications. J Biol Chem. 1978 Oct 25; 253(20):7361-8.
journal title abbreviation: J Biol Chem
publication date: 1978-10-25T00:00:00
year: 1978
type: Academic Article
type: Article
type: Document
type: Information Resource

The C2 domain of PKCdelta is a phosphotyrosine binding domain.
PubMed Identifier: 15851033
author list: Benes CH, Wu N, Elia AE, Dharia T, Cantley LC, Soltoff SP
published in: Cell
information resource reference: The C2 domain of PKCdelta is a phosphotyrosine binding domain. Cell. 2005 Apr 22; 121(2):271-80.
journal title abbreviation: Cell
publication date: 2005-04-22T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection.
PubMed Identifier: 16482216
author list: Pendaries C, Tronchère H, Arbibe L, Mounier J, Gozani O, Cantley L, Fry MJ, Gaits-Iacovoni F, Sansonetti PJ, Payrastre B
published in: The EMBO journal
information resource reference: PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection. EMBO J. 2006 Mar 08; 25(5):1024-34.
journal title abbreviation: EMBO J
publication date: 2006-02-16T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Clathrin-coated vesicles contain an ATP-dependent proton pump.
PubMed Identifier: 6131417
author list: Forgac M, Cantley L, Wiedenmann B, Altstiel L, Branton D
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Clathrin-coated vesicles contain an ATP-dependent proton pump. Proc Natl Acad Sci U S A. 1983 Mar; 80(5):1300-3.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1983-03-01T00:00:00
year: 1983
type: Academic Article
type: Article
type: Document
type: Information Resource

The plasma membrane (Mg2+)-dependent adenosine triphosphatase from the human erythrocyte is not an ion pump.
PubMed Identifier: 6148424
author list: Forgac M, Cantley L
published in: The Journal of membrane biology
information resource reference: The plasma membrane (Mg2+)-dependent adenosine triphosphatase from the human erythrocyte is not an ion pump. J Membr Biol. 1984; 80(2):185-90.
journal title abbreviation: J Membr Biol
publication date: 1984-01-01T00:00:00
year: 1984
type: Academic Article
type: Article
type: Document
type: Information Resource

Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation.
PubMed Identifier: 8235613
author list: Ravichandran KS, Lee KK, Songyang Z, Cantley LC, Burn P, Burakoff SJ
published in: Science (New York, N.Y.)
information resource reference: Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation. Science. 1993 Nov 05; 262(5135):902-5.
journal title abbreviation: Science
publication date: 1993-11-05T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Association of phosphatidylinositol 3-kinase, via the SH2 domains of p85, with focal adhesion kinase in polyoma middle t-transformed fibroblasts.
PubMed Identifier: 8603102
author list: Bachelot C, Rameh L, Parsons T, Cantley LC
published in: Biochimica et biophysica acta
information resource reference: Association of phosphatidylinositol 3-kinase, via the SH2 domains of p85, with focal adhesion kinase in polyoma middle t-transformed fibroblasts. Biochim Biophys Acta. 1996 Mar 27; 1311(1):45-52.
journal title abbreviation: Biochim Biophys Acta
publication date: 1996-03-27T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Cell regulation.
PubMed Identifier: 9069268
author list: Cantley LC, Coughlin SR
published in: Current opinion in cell biology
information resource reference: Cell regulation. Curr Opin Cell Biol. 1997 Apr 01; 9(2):131-3.
journal title abbreviation: Curr Opin Cell Biol
publication date: 1997-04-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity.
PubMed Identifier: 11278902
author list: Bertenshaw GP, Turk BE, Hubbard SJ, Matters GL, Bylander JE, Crisman JM, Cantley LC, Bond JS
published in: The Journal of biological chemistry
information resource reference: Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity. J Biol Chem. 2001 Apr 20; 276(16):13248-55.
journal title abbreviation: J Biol Chem
publication date: 2001-01-22T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Lipid second messengers.
PubMed Identifier: 8181054
author list: Liscovitch M, Cantley LC
published in: Cell
information resource reference: Lipid second messengers. Cell. 1994 May 06; 77(3):329-34.
journal title abbreviation: Cell
publication date: 1994-05-06T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

The erbB3 gene product is a receptor for heregulin.
PubMed Identifier: 8188716
author list: Carraway KL, Sliwkowski MX, Akita R, Platko JV, Guy PM, Nuijens A, Diamonti AJ, Vandlen RL, Cantley LC, Cerione RA
published in: The Journal of biological chemistry
information resource reference: The erbB3 gene product is a receptor for heregulin. J Biol Chem. 1994 May 13; 269(19):14303-6.
journal title abbreviation: J Biol Chem
publication date: 1994-05-13T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Fluorescence energy transfer between ligand binding sites on chloroplast coupling factor 1.
PubMed Identifier: 1148188
author list: Cantley LC, Hammes GG
published in: Biochemistry
information resource reference: Fluorescence energy transfer between ligand binding sites on chloroplast coupling factor 1. Biochemistry. 1975 Jul; 14(13):2976-81.
journal title abbreviation: Biochemistry
publication date: 1975-07-01T00:00:00
year: 1975
type: Academic Article
type: Article
type: Document
type: Information Resource

Pyruvate kinase M2 is a phosphotyrosine-binding protein.
PubMed Identifier: 18337815
author list: Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC
published in: Nature
information resource reference: Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature. 2008 Mar 13; 452(7184):181-6.
journal title abbreviation: Nature
publication date: 2008-03-13T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Determination of protease cleavage site motifs using mixture-based oriented peptide libraries.
PubMed Identifier: 11433279
author list: Turk BE, Huang LL, Piro ET, Cantley LC
published in: Nature biotechnology
information resource reference: Determination of protease cleavage site motifs using mixture-based oriented peptide libraries. Nat Biotechnol. 2001 Jul; 19(7):661-7.
journal title abbreviation: Nat Biotechnol
publication date: 2001-07-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 10121
type: Authorship
author rank in publication: 10
linked author: Cantley, Lewis
linked information resource: TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins.

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.
PubMed Identifier: 19740074
author list: Nichols RJ, Dzamko N, Hutti JE, Cantley LC, Deak M, Moran J, Bamborough P, Reith AD, Alessi DR
published in: The Biochemical journal
information resource reference: Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. Biochem J. 2009 Oct 23; 424(1):47-60.
journal title abbreviation: Biochem J
publication date: 2009-10-23T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase.
PubMed Identifier: 16006513
author list: Luo J, Sobkiw CL, Logsdon NM, Watt JM, Signoretti S, O'Connell F, Shin E, Shim Y, Pao L, Neel BG, Depinho RA, Loda M, Cantley LC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10238-43.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2005-07-08T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.
PubMed Identifier: 16166093
author list: Barbour LA, Mizanoor Rahman S, Gurevich I, Leitner JW, Fischer SJ, Roper MD, Knotts TA, Vo Y, McCurdy CE, Yakar S, Leroith D, Kahn CR, Cantley LC, Friedman JE, Draznin B
published in: The Journal of biological chemistry
information resource reference: Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess. J Biol Chem. 2005 Nov 11; 280(45):37489-94.
journal title abbreviation: J Biol Chem
publication date: 2005-09-08T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 103534
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: The role of ion fluxes in hematopoietic cell differentiation.

Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain.
PubMed Identifier: 2553693
author list: Serunian LA, Haber MT, Fukui T, Kim JW, Rhee SG, Lowenstein JM, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain. J Biol Chem. 1989 Oct 25; 264(30):17809-15.
journal title abbreviation: J Biol Chem
publication date: 1989-10-25T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Bovine brain contains two types of phosphatidylinositol kinase.
PubMed Identifier: 2827737
author list: Endemann G, Dunn SN, Cantley LC
published in: Biochemistry
information resource reference: Bovine brain contains two types of phosphatidylinositol kinase. Biochemistry. 1987 Oct 20; 26(21):6845-52.
journal title abbreviation: Biochemistry
publication date: 1987-10-20T00:00:00
year: 1987
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.
PubMed Identifier: 7687742
author list: Birge RB, Fajardo JE, Reichman C, Shoelson SE, Songyang Z, Cantley LC, Hanafusa H
published in: Molecular and cellular biology
information resource reference: Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts. Mol Cell Biol. 1993 Aug; 13(8):4648-56.
journal title abbreviation: Mol Cell Biol
publication date: 1993-08-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

SH2 domain specificity determination using oriented phosphopeptide library.
PubMed Identifier: 8531712
author list: Songyang Z, Cantley LC
published in: Methods in enzymology
information resource reference: SH2 domain specificity determination using oriented phosphopeptide library. Methods Enzymol. 1995; 254:523-35.
journal title abbreviation: Methods Enzymol
publication date: 1995-01-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 10721
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: The LKB1 tumor suppressor negatively regulates mTOR signaling.

Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis.
PubMed Identifier: 17483449
author list: Chang JD, Sukhova GK, Libby P, Schvartz E, Lichtenstein AH, Field SJ, Kennedy C, Madhavarapu S, Luo J, Wu D, Cantley LC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):8077-82.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2007-05-02T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular phylogenetics of mastodon and Tyrannosaurus rex.
PubMed Identifier: 18436782
author list: Organ CL, Schweitzer MH, Zheng W, Freimark LM, Cantley LC, Asara JM
published in: Science (New York, N.Y.)
information resource reference: Molecular phylogenetics of mastodon and Tyrannosaurus rex. Science. 2008 Apr 25; 320(5875):499.
journal title abbreviation: Science
publication date: 2008-04-25T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

A sweet new role for EGFR in cancer.
PubMed Identifier: 18455118
author list: Engelman JA, Cantley LC
published in: Cancer cell
information resource reference: A sweet new role for EGFR in cancer. Cancer Cell. 2008 May; 13(5):375-6.
journal title abbreviation: Cancer Cell
publication date: 2008-05-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Oncogenes and phosphatidylinositol turnover.
PubMed Identifier: 2437850
author list: Cantley LC, Whitman M, Chahwala S, Fleischman L, Kaplan DR, Schaffhausen BS, Roberts TM
published in: Annals of the New York Academy of Sciences
information resource reference: Oncogenes and phosphatidylinositol turnover. Ann N Y Acad Sci. 1986; 488:481-90.
journal title abbreviation: Ann N Y Acad Sci
publication date: 1986-01-01T00:00:00
year: 1986
type: Academic Article
type: Article
type: Document
type: Information Resource

Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha.
PubMed Identifier: 19705443
author list: Mouta-Bellum C, Kirov A, Miceli-Libby L, Mancini ML, Petrova TV, Liaw L, Prudovsky I, Thorpe PE, Miura N, Cantley LC, Alitalo K, Fruman DA, Vary CP
published in: Developmental dynamics : an official publication of the American Association of Anatomists
information resource reference: Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha. Dev Dyn. 2009 Oct; 238(10):2670-9.
journal title abbreviation: Dev Dyn
publication date: 2009-10-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

CV-1 cell recipients of the mouse ouabain resistance gene express a ouabain-insensitive Na,K-ATPase after growth in cardioactive steroids.
PubMed Identifier: 2826456
author list: Schulz JT, Cantley LC
published in: The Journal of biological chemistry
information resource reference: CV-1 cell recipients of the mouse ouabain resistance gene express a ouabain-insensitive Na,K-ATPase after growth in cardioactive steroids. J Biol Chem. 1988 Jan 15; 263(2):624-32.
journal title abbreviation: J Biol Chem
publication date: 1988-01-15T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.
PubMed Identifier: 12271141
author list: Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13571-6.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2002-09-23T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha.
PubMed Identifier: 12435753
author list: Hallmann D, Trümper K, Trusheim H, Ueki K, Kahn CR, Cantley LC, Fruman DA, Hörsch D
published in: The Journal of biological chemistry
information resource reference: Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha. J Biol Chem. 2003 Feb 14; 278(7):5099-108.
journal title abbreviation: J Biol Chem
publication date: 2002-11-14T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

A rapid method for determining protein kinase phosphorylation specificity.
PubMed Identifier: 15782149
author list: Hutti JE, Jarrell ET, Chang JD, Abbott DW, Storz P, Toker A, Cantley LC, Turk BE
published in: Nature methods
information resource reference: A rapid method for determining protein kinase phosphorylation specificity. Nat Methods. 2004 Oct; 1(1):27-9.
journal title abbreviation: Nat Methods
publication date: 2004-10-01T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

In-gel stable isotope labeling for relative quantification using mass spectrometry.
PubMed Identifier: 17406210
author list: Asara JM, Zhang X, Zheng B, Maroney LA, Christofk HR, Wu N, Cantley LC
published in: Nature protocols
information resource reference: In-gel stable isotope labeling for relative quantification using mass spectrometry. Nat Protoc. 2006; 1(1):46-51.
journal title abbreviation: Nat Protoc
publication date: 2006-01-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 105882
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling.

The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.
PubMed Identifier: 11430832
author list: Karuman P, Gozani O, Odze RD, Zhou XC, Zhu H, Shaw R, Brien TP, Bozzuto CD, Ooi D, Cantley LC, Yuan J
published in: Molecular cell
information resource reference: The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Mol Cell. 2001 Jun; 7(6):1307-19.
journal title abbreviation: Mol Cell
publication date: 2001-06-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes.
PubMed Identifier: 11781359
author list: Mauvais-Jarvis F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ, Iannacone M, Accili D, Cantley LC, Kahn CR
published in: The Journal of clinical investigation
information resource reference: Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. J Clin Invest. 2002 Jan; 109(1):141-9.
journal title abbreviation: J Clin Invest
publication date: 2002-01-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26.
PubMed Identifier: 12119297
author list: Park HI, Turk BE, Gerkema FE, Cantley LC, Sang QX
published in: The Journal of biological chemistry
information resource reference: Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26. J Biol Chem. 2002 Sep 20; 277(38):35168-75.
journal title abbreviation: J Biol Chem
publication date: 2002-07-15T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.
PubMed Identifier: 20498699
author list: Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, Manolopoulou M, Tang WJ, Stein RL, Cuny GD, Selkoe DJ
published in: PloS one
information resource reference: Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. PLoS One. 2010 May 07; 5(5):e10504.
journal title abbreviation: PLoS One
publication date: 2010-05-07T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice.
PubMed Identifier: 20534477
author list: Lee SH, Poulogiannis G, Pyne S, Jia S, Zou L, Signoretti S, Loda M, Cantley LC, Roberts TM
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):11002-7.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2010-06-01T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Hypothalamic factor inhibits the (Na,K)ATPase from the extracellular surface. Mechanism of inhibition.
PubMed Identifier: 2981828
author list: Carilli CT, Berne M, Cantley LC, Haupert GT
published in: The Journal of biological chemistry
information resource reference: Hypothalamic factor inhibits the (Na,K)ATPase from the extracellular surface. Mechanism of inhibition. J Biol Chem. 1985 Jan 25; 260(2):1027-31.
journal title abbreviation: J Biol Chem
publication date: 1985-01-25T00:00:00
year: 1985
type: Academic Article
type: Article
type: Document
type: Information Resource

The role of ion fluxes in hematopoietic cell differentiation.
PubMed Identifier: 2996016
author list: Rosoff PM, Cantley LC
published in: Progress in clinical and biological research
information resource reference: The role of ion fluxes in hematopoietic cell differentiation. Prog Clin Biol Res. 1985; 184:331-9.
journal title abbreviation: Prog Clin Biol Res
publication date: 1985-01-01T00:00:00
year: 1985
type: Academic Article
type: Article
type: Document
type: Information Resource

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.
PubMed Identifier: 23535601
author list: Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, DePinho RA, Cantley LC, Kimmelman AC
published in: Nature
information resource reference: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 2013 Apr 04; 496(7443):101-5.
journal title abbreviation: Nature
publication date: 2013-03-27T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Cell cycle dependence of inositol phosphate levels in neuroblastoma cells.
PubMed Identifier: 3177626
author list: Fleischman LF, Cantley L
published in: The American journal of physiology
information resource reference: Cell cycle dependence of inositol phosphate levels in neuroblastoma cells. Am J Physiol. 1988 Oct; 255(4 Pt 1):C531-5.
journal title abbreviation: Am J Physiol
publication date: 1988-10-01T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 115276
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Cell cycle dependence of inositol phosphate levels in neuroblastoma cells.

Characterization of monovalent ion transport systems in an insect cell line (Manduca sexta embryonic cell line CHE).
PubMed Identifier: 6480706
author list: English LH, Cantley LC
published in: Journal of cellular physiology
information resource reference: Characterization of monovalent ion transport systems in an insect cell line (Manduca sexta embryonic cell line CHE). J Cell Physiol. 1984 Oct; 121(1):125-32.
journal title abbreviation: J Cell Physiol
publication date: 1984-10-01T00:00:00
year: 1984
type: Academic Article
type: Article
type: Document
type: Information Resource

Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.
PubMed Identifier: 8058768
author list: Guy PM, Platko JV, Cantley LC, Cerione RA, Carraway KL
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. Proc Natl Acad Sci U S A. 1994 Aug 16; 91(17):8132-6.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1994-08-16T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Investigation of quercetin binding sites on chloroplast coupling factor 1.
PubMed Identifier: 1247500
author list: Cantley LC, Hammes GG
published in: Biochemistry
information resource reference: Investigation of quercetin binding sites on chloroplast coupling factor 1. Biochemistry. 1976 Jan 13; 15(1):1-8.
journal title abbreviation: Biochemistry
publication date: 1976-01-13T00:00:00
year: 1976
type: Academic Article
type: Article
type: Document
type: Information Resource

Extracellular ATP elevates intracellular free calcium in rat parotid acinar cells.
PubMed Identifier: 3426590
author list: McMillian MK, Soltoff SP, Cantley LC, Talamo BR
published in: Biochemical and biophysical research communications
information resource reference: Extracellular ATP elevates intracellular free calcium in rat parotid acinar cells. Biochem Biophys Res Commun. 1987 Dec 16; 149(2):523-30.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 1987-12-16T00:00:00
year: 1987
type: Academic Article
type: Article
type: Document
type: Information Resource

Evidence for an alternative glycolytic pathway in rapidly proliferating cells.
PubMed Identifier: 20847263
author list: Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC
published in: Science (New York, N.Y.)
information resource reference: Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science. 2010 Sep 17; 329(5998):1492-9.
journal title abbreviation: Science
publication date: 2010-09-17T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate.
PubMed Identifier: 2833705
author list: Whitman M, Downes CP, Keeler M, Keller T, Cantley L
published in: Nature
information resource reference: Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature. 1988 Apr 14; 332(6165):644-6.
journal title abbreviation: Nature
publication date: 1988-04-14T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.
PubMed Identifier: 22052977
author list: Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang JK, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS, Thomas CJ, Vander Heiden MG, Cantley LC
published in: Science (New York, N.Y.)
information resource reference: Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science. 2011 Dec 02; 334(6060):1278-83.
journal title abbreviation: Science
publication date: 2011-11-03T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Systemic elevation of PTEN induces a tumor-suppressive metabolic state.
PubMed Identifier: 22401813
author list: Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP
published in: Cell
information resource reference: Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell. 2012 Mar 30; 149(1):49-62.
journal title abbreviation: Cell
publication date: 2012-03-06T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake.
PubMed Identifier: 22727014
author list: Dagon Y, Hur E, Zheng B, Wellenstein K, Cantley LC, Kahn BB
published in: Cell metabolism
information resource reference: p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake. Cell Metab. 2012 Jul 03; 16(1):104-12.
journal title abbreviation: Cell Metab
publication date: 2012-06-21T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Stimulation of the T3-T cell receptor-associated Ca2+ influx enhances the activity of the Na+/H+ exchanger in a leukemic human T cell line.
PubMed Identifier: 2997191
author list: Rosoff PM, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Stimulation of the T3-T cell receptor-associated Ca2+ influx enhances the activity of the Na+/H+ exchanger in a leukemic human T cell line. J Biol Chem. 1985 Nov 15; 260(26):14053-9.
journal title abbreviation: J Biol Chem
publication date: 1985-11-15T00:00:00
year: 1985
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 104285
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes.

Identification of small molecule inhibitors of anthrax lethal factor.
PubMed Identifier: 14718925
author list: Panchal RG, Hermone AR, Nguyen TL, Wong TY, Schwarzenbacher R, Schmidt J, Lane D, McGrath C, Turk BE, Burnett J, Aman MJ, Little S, Sausville EA, Zaharevitz DW, Cantley LC, Liddington RC, Gussio R, Bavari S
published in: Nature structural & molecular biology
information resource reference: Identification of small molecule inhibitors of anthrax lethal factor. Nat Struct Mol Biol. 2004 Jan; 11(1):67-72.
journal title abbreviation: Nat Struct Mol Biol
publication date: 2003-12-29T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice.
PubMed Identifier: 15713620
author list: Brachmann SM, Ueki K, Engelman JA, Kahn RC, Cantley LC
published in: Molecular and cellular biology
information resource reference: Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice. Mol Cell Biol. 2005 Mar; 25(5):1596-607.
journal title abbreviation: Mol Cell Biol
publication date: 2005-03-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex.
PubMed Identifier: 16043515
author list: Luo J, Field SJ, Lee JY, Engelman JA, Cantley LC
published in: The Journal of cell biology
information resource reference: The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. J Cell Biol. 2005 Aug 01; 170(3):455-64.
journal title abbreviation: J Cell Biol
publication date: 2005-07-25T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Wortmannin-C20 conjugates generate wortmannin.
PubMed Identifier: 16420059
author list: Yuan H, Luo J, Weissleder R, Cantley L, Josephson L
published in: Journal of medicinal chemistry
information resource reference: Wortmannin-C20 conjugates generate wortmannin. J Med Chem. 2006 Jan 26; 49(2):740-7.
journal title abbreviation: J Med Chem
publication date: 2006-01-26T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta.
PubMed Identifier: 16679292
author list: Taniguchi CM, Kondo T, Sajan M, Luo J, Bronson R, Asano T, Farese R, Cantley LC, Kahn CR
published in: Cell metabolism
information resource reference: Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metab. 2006 May; 3(5):343-53.
journal title abbreviation: Cell Metab
publication date: 2006-05-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
PubMed Identifier: 16847462
author list: Engelman JA, Luo J, Cantley LC
published in: Nature reviews. Genetics
information resource reference: The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet. 2006 Aug; 7(8):606-19.
journal title abbreviation: Nat Rev Genet
publication date: 2006-08-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 105651
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Characterization of monovalent ion transport systems in an insect cell line (Manduca sexta embryonic cell line CHE).

The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.
PubMed Identifier: 17283057
author list: Taniguchi CM, Aleman JO, Ueki K, Luo J, Asano T, Kaneto H, Stephanopoulos G, Cantley LC, Kahn CR
published in: Molecular and cellular biology
information resource reference: The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance. Mol Cell Biol. 2007 Apr; 27(8):2830-40.
journal title abbreviation: Mol Cell Biol
publication date: 2007-02-05T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphoinositide kinases.
PubMed Identifier: 2176895
author list: Carpenter CL, Cantley LC
published in: Biochemistry
information resource reference: Phosphoinositide kinases. Biochemistry. 1990 Dec 25; 29(51):11147-56.
journal title abbreviation: Biochemistry
publication date: 1990-12-25T00:00:00
year: 1990
type: Academic Article
type: Article
type: Document
type: Information Resource

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.
PubMed Identifier: 18337823
author list: Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC
published in: Nature
information resource reference: The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 2008 Mar 13; 452(7184):230-3.
journal title abbreviation: Nature
publication date: 2008-03-13T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Lewis C. Cantley.
PubMed Identifier: 19655422
author list: Cantley LC
published in: Current biology : CB
information resource reference: Lewis C. Cantley. Curr Biol. 2009 Jul 28; 19(14):R540-1.
journal title abbreviation: Curr Biol
publication date: 2009-07-28T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Development of an intracellularly acting inhibitory peptide selective for PKN.
PubMed Identifier: 19857203
author list: Shiga K, Takayama K, Futaki S, Hutti JE, Cantley LC, Ueki K, Ono Y, Mukai H
published in: The Biochemical journal
information resource reference: Development of an intracellularly acting inhibitory peptide selective for PKN. Biochem J. 2009 Dec 23; 425(2):445-53.
journal title abbreviation: Biochem J
publication date: 2009-12-23T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx.
PubMed Identifier: 2578888
author list: Oettgen HC, Terhorst C, Cantley LC, Rosoff PM
published in: Cell
information resource reference: Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx. Cell. 1985 Mar; 40(3):583-90.
journal title abbreviation: Cell
publication date: 1985-03-01T00:00:00
year: 1985
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase.
PubMed Identifier: 17204563
author list: Zheng B, Cantley LC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):819-22.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2007-01-04T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Location of the stilbenedisulfonate binding site of the human erythrocyte anion-exchange system by resonance energy transfer.
PubMed Identifier: 497152
author list: Rao A, Martin P, Reithmeier RA, Cantley LC
published in: Biochemistry
information resource reference: Location of the stilbenedisulfonate binding site of the human erythrocyte anion-exchange system by resonance energy transfer. Biochemistry. 1979 Oct 16; 18(21):4505-16.
journal title abbreviation: Biochemistry
publication date: 1979-10-16T00:00:00
year: 1979
type: Academic Article
type: Article
type: Document
type: Information Resource

Glutathione reduces cytoplasmic vanadate. Mechanism and physiological implications.
PubMed Identifier: 6245716
author list: Macara IG, Kustin K, Cantley LC
published in: Biochimica et biophysica acta
information resource reference: Glutathione reduces cytoplasmic vanadate. Mechanism and physiological implications. Biochim Biophys Acta. 1980 Apr 17; 629(1):95-106.
journal title abbreviation: Biochim Biophys Acta
publication date: 1980-04-17T00:00:00
year: 1980
type: Academic Article
type: Article
type: Document
type: Information Resource

A study of the vanadate-trapped state of the (Na,K)-ATPase. Evidence against interacting nucleotide site models.
PubMed Identifier: 6253455
author list: Smith RL, Zinn K, Cantley LC
published in: The Journal of biological chemistry
information resource reference: A study of the vanadate-trapped state of the (Na,K)-ATPase. Evidence against interacting nucleotide site models. J Biol Chem. 1980 Oct 25; 255(20):9852-9.
journal title abbreviation: J Biol Chem
publication date: 1980-10-25T00:00:00
year: 1980
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphorylation of the (Na,K)-ATPase by a plasma membrane-bound protein kinase in friend erythroleukemia cells.
PubMed Identifier: 6304047
author list: Yeh LA, Ling L, English L, Cantley L
published in: The Journal of biological chemistry
information resource reference: Phosphorylation of the (Na,K)-ATPase by a plasma membrane-bound protein kinase in friend erythroleukemia cells. J Biol Chem. 1983 May 25; 258(10):6567-74.
journal title abbreviation: J Biol Chem
publication date: 1983-05-25T00:00:00
year: 1983
type: Academic Article
type: Article
type: Document
type: Information Resource

Calcium regulates the commitment of murine erythroleukemia cells to terminal erythroid differentiation.
PubMed Identifier: 6793600
author list: Bridges K, Levenson R, Housman D, Cantley L
published in: The Journal of cell biology
information resource reference: Calcium regulates the commitment of murine erythroleukemia cells to terminal erythroid differentiation. J Cell Biol. 1981 Aug; 90(2):542-4.
journal title abbreviation: J Cell Biol
publication date: 1981-08-01T00:00:00
year: 1981
type: Academic Article
type: Article
type: Document
type: Information Resource

A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain.
PubMed Identifier: 8610109
author list: O'Bryan JP, Songyang Z, Cantley L, Der CJ, Pawson T
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. Proc Natl Acad Sci U S A. 1996 Apr 02; 93(7):2729-34.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1996-04-02T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 11530
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Interleukin 3-dependent survival by the Akt protein kinase.

Binding specificity and mutational analysis of the phosphotyrosine binding domain of the brain-specific adaptor protein ShcC.
PubMed Identifier: 8662772
author list: O'Bryan JP, Martin CB, Songyang Z, Cantley LC, Der CJ
published in: The Journal of biological chemistry
information resource reference: Binding specificity and mutational analysis of the phosphotyrosine binding domain of the brain-specific adaptor protein ShcC. J Biol Chem. 1996 May 17; 271(20):11787-91.
journal title abbreviation: J Biol Chem
publication date: 1996-05-17T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.
PubMed Identifier: 18382766
author list: Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK
published in: The Journal of clinical investigation
information resource reference: Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. J Clin Invest. 2008 May; 118(5):1796-805.
journal title abbreviation: J Clin Invest
publication date: 2008-05-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis.
PubMed Identifier: 19407199
author list: Schweitzer MH, Zheng W, Organ CL, Avci R, Suo Z, Freimark LM, Lebleu VS, Duncan MB, Vander Heiden MG, Neveu JM, Lane WS, Cottrell JS, Horner JR, Cantley LC, Kalluri R, Asara JM
published in: Science (New York, N.Y.)
information resource reference: Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science. 2009 May 01; 324(5927):626-31.
journal title abbreviation: Science
publication date: 2009-05-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif.
PubMed Identifier: 7541030
author list: Songyang Z, Margolis B, Chaudhuri M, Shoelson SE, Cantley LC
published in: The Journal of biological chemistry
information resource reference: The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif. J Biol Chem. 1995 Jun 23; 270(25):14863-6.
journal title abbreviation: J Biol Chem
publication date: 1995-06-23T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 116895
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade.

Authorship 104075
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Phosphoinositide binding domains: embracing 3-phosphate.

Getting knit-PI3Ky: PIK3CA mutation status to direct multimodality therapy?
PubMed Identifier: 19903790
author list: Myers AP, Meyerhardt JA, Cantley LC
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: Getting knit-PI3Ky: PIK3CA mutation status to direct multimodality therapy? Clin Cancer Res. 2009 Nov 15; 15(22):6748-50.
journal title abbreviation: Clin Cancer Res
publication date: 2009-11-10T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphatidylinositol metabolism and polyoma-mediated transformation.
PubMed Identifier: 2424008
author list: Kaplan DR, Whitman M, Schaffhausen B, Raptis L, Garcea RL, Pallas D, Roberts TM, Cantley L
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Phosphatidylinositol metabolism and polyoma-mediated transformation. Proc Natl Acad Sci U S A. 1986 Jun; 83(11):3624-8.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1986-06-01T00:00:00
year: 1986
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of small molecule inhibitors of pyruvate kinase M2.
PubMed Identifier: 20005212
author list: Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC
published in: Biochemical pharmacology
information resource reference: Identification of small molecule inhibitors of pyruvate kinase M2. Biochem Pharmacol. 2010 Apr 15; 79(8):1118-24.
journal title abbreviation: Biochem Pharmacol
publication date: 2009-12-11T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 117633
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement.

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells.
PubMed Identifier: 2467744
author list: Auger KR, Serunian LA, Soltoff SP, Libby P, Cantley LC
published in: Cell
information resource reference: PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell. 1989 Apr 07; 57(1):167-75.
journal title abbreviation: Cell
publication date: 1989-04-07T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Cancer's insatiable appetite.
PubMed Identifier: 19816448
author list: Locasale JW, Cantley LC, Vander Heiden MG
published in: Nature biotechnology
information resource reference: Cancer's insatiable appetite. Nat Biotechnol. 2009 Oct; 27(10):916-7.
journal title abbreviation: Nat Biotechnol
publication date: 2009-10-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeting the PI3K signaling pathway in cancer.
PubMed Identifier: 20006486
author list: Wong KK, Engelman JA, Cantley LC
published in: Current opinion in genetics & development
information resource reference: Targeting the PI3K signaling pathway in cancer. Curr Opin Genet Dev. 2010 Feb; 20(1):87-90.
journal title abbreviation: Curr Opin Genet Dev
publication date: 2009-12-16T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Characterization of PXK as a protein involved in epidermal growth factor receptor trafficking.
PubMed Identifier: 20086096
author list: Takeuchi H, Takeuchi T, Gao J, Cantley LC, Hirata M
published in: Molecular and cellular biology
information resource reference: Characterization of PXK as a protein involved in epidermal growth factor receptor trafficking. Mol Cell Biol. 2010 Apr; 30(7):1689-702.
journal title abbreviation: Mol Cell Biol
publication date: 2010-01-19T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 11580
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Structural changes in (Na+ + K+)-ATPase accompanying detergent inactivation.

Characterization of a Ca2+-stimulated Mg2+-dependent adenosine triphosphatase in Friend murine erythroleukemia cell plasma membranes.
PubMed Identifier: 6150038
author list: Debetto P, Cantley L
published in: The Journal of biological chemistry
information resource reference: Characterization of a Ca2+-stimulated Mg2+-dependent adenosine triphosphatase in Friend murine erythroleukemia cell plasma membranes. J Biol Chem. 1984 Nov 25; 259(22):13824-31.
journal title abbreviation: J Biol Chem
publication date: 1984-11-25T00:00:00
year: 1984
type: Academic Article
type: Article
type: Document
type: Information Resource

Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.
PubMed Identifier: 6326105
author list: Sugimoto Y, Whitman M, Cantley LC, Erikson RL
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol. Proc Natl Acad Sci U S A. 1984 Apr; 81(7):2117-21.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1984-04-01T00:00:00
year: 1984
type: Academic Article
type: Article
type: Document
type: Information Resource

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.
PubMed Identifier: 19029981
author list: Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, Lightbown A, Simendinger J, Li T, Padera RF, García-Echeverría C, Weissleder R, Mahmood U, Cantley LC, Wong KK
published in: Nature medicine
information resource reference: Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med. 2008 Dec; 14(12):1351-6.
journal title abbreviation: Nat Med
publication date: 2008-11-30T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Understanding the Warburg effect: the metabolic requirements of cell proliferation.
PubMed Identifier: 19460998
author list: Vander Heiden MG, Cantley LC, Thompson CB
published in: Science (New York, N.Y.)
information resource reference: Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009 May 22; 324(5930):1029-33.
journal title abbreviation: Science
publication date: 2009-05-22T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 13156
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle.

Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange.
PubMed Identifier: 6144681
author list: Rosoff PM, Stein LF, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange. J Biol Chem. 1984 Jun 10; 259(11):7056-60.
journal title abbreviation: J Biol Chem
publication date: 1984-06-10T00:00:00
year: 1984
type: Academic Article
type: Article
type: Document
type: Information Resource

Evidence that inhibitors of anion exchange induce a transmembrane conformational change in band 3.
PubMed Identifier: 6185490
author list: Macara IG, Kuo S, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Evidence that inhibitors of anion exchange induce a transmembrane conformational change in band 3. J Biol Chem. 1983 Feb 10; 258(3):1785-92.
journal title abbreviation: J Biol Chem
publication date: 1983-02-10T00:00:00
year: 1983
type: Academic Article
type: Article
type: Document
type: Information Resource

Vanadium stimulates the (Na+,K+) pump in friend erythroleukemia cells and blocks erythropoiesis.
PubMed Identifier: 6311842
author list: English LH, Macara IG, Cantley LC
published in: The Journal of cell biology
information resource reference: Vanadium stimulates the (Na+,K+) pump in friend erythroleukemia cells and blocks erythropoiesis. J Cell Biol. 1983 Oct; 97(4):1299-302.
journal title abbreviation: J Cell Biol
publication date: 1983-10-01T00:00:00
year: 1983
type: Academic Article
type: Article
type: Document
type: Information Resource

The (Na,K)-ATPase of Friend erythroleukemia cells is phosphorylated near the ATP hydrolysis by an endogenous membrane-bound kinase.
PubMed Identifier: 6323456
author list: Ling L, Cantley L
published in: The Journal of biological chemistry
information resource reference: The (Na,K)-ATPase of Friend erythroleukemia cells is phosphorylated near the ATP hydrolysis by an endogenous membrane-bound kinase. J Biol Chem. 1984 Apr 10; 259(7):4089-95.
journal title abbreviation: J Biol Chem
publication date: 1984-04-10T00:00:00
year: 1984
type: Academic Article
type: Article
type: Document
type: Information Resource

Type 2 phosphatidylinositol 4-kinase is recruited to CD4 in response to CD4 cross-linking.
PubMed Identifier: 7748894
author list: Pertile P, Cantley LC
published in: Biochimica et biophysica acta
information resource reference: Type 2 phosphatidylinositol 4-kinase is recruited to CD4 in response to CD4 cross-linking. Biochim Biophys Acta. 1995 Apr 27; 1248(2):129-34.
journal title abbreviation: Biochim Biophys Acta
publication date: 1995-04-27T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Signal transduction and membrane traffic: the PITP/phosphoinositide connection.
PubMed Identifier: 7774006
author list: Liscovitch M, Cantley LC
published in: Cell
information resource reference: Signal transduction and membrane traffic: the PITP/phosphoinositide connection. Cell. 1995 Jun 02; 81(5):659-62.
journal title abbreviation: Cell
publication date: 1995-06-02T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Large-scale characterization of HeLa cell nuclear phosphoproteins.
PubMed Identifier: 15302935
author list: Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A. 2004 Aug 17; 101(33):12130-5.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2004-08-09T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Synthesis and activity of C11-modified wortmannin probes for PI3 kinase.
PubMed Identifier: 15898736
author list: Yuan H, Luo J, Field S, Weissleder R, Cantley L, Josephson L
published in: Bioconjugate chemistry
information resource reference: Synthesis and activity of C11-modified wortmannin probes for PI3 kinase. Bioconjug Chem. 2005 May-Jun; 16(3):669-75.
journal title abbreviation: Bioconjug Chem
publication date: 2005-05-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia.
PubMed Identifier: 16679293
author list: Luo J, Sobkiw CL, Hirshman MF, Logsdon MN, Li TQ, Goodyear LJ, Cantley LC
published in: Cell metabolism
information resource reference: Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia. Cell Metab. 2006 May; 3(5):355-66.
journal title abbreviation: Cell Metab
publication date: 2006-05-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen.
PubMed Identifier: 18324724
author list: Asara JM, Christofk HR, Freimark LM, Cantley LC
published in: Proteomics
information resource reference: A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen. Proteomics. 2008 Mar; 8(5):994-9.
journal title abbreviation: Proteomics
publication date: 2008-03-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 123222
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Interactions between transport inhibitors at the anion binding sites of the band 3 dimer.

Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength.
PubMed Identifier: 9346906
author list: Duckworth BC, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength. J Biol Chem. 1997 Oct 31; 272(44):27665-70.
journal title abbreviation: J Biol Chem
publication date: 1997-10-31T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

PI3K enters beta-testing.
PubMed Identifier: 18762017
author list: Shaywitz AJ, Courtney KD, Patnaik A, Cantley LC
published in: Cell metabolism
information resource reference: PI3K enters beta-testing. Cell Metab. 2008 Sep; 8(3):179-81.
journal title abbreviation: Cell Metab
publication date: 2008-09-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer.
PubMed Identifier: 19237633
author list: Ogino S, Nosho K, Kirkner GJ, Shima K, Irahara N, Kure S, Chan AT, Engelman JA, Kraft P, Cantley LC, Giovannucci EL, Fuchs CS
published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
information resource reference: PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer. J Clin Oncol. 2009 Mar 20; 27(9):1477-84.
journal title abbreviation: J Clin Oncol
publication date: 2009-02-23T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.
PubMed Identifier: 19481526
author list: Hutti JE, Shen RR, Abbott DW, Zhou AY, Sprott KM, Asara JM, Hahn WC, Cantley LC
published in: Molecular cell
information resource reference: Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation. Mol Cell. 2009 May 14; 34(4):461-72.
journal title abbreviation: Mol Cell
publication date: 2009-05-14T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

A fluorescent reporter of AMPK activity and cellular energy stress.
PubMed Identifier: 21459332
author list: Tsou P, Zheng B, Hsu CH, Sasaki AT, Cantley LC
published in: Cell metabolism
information resource reference: A fluorescent reporter of AMPK activity and cellular energy stress. Cell Metab. 2011 Apr 06; 13(4):476-486.
journal title abbreviation: Cell Metab
publication date: 2011-04-06T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Role of mitochondrial membrane potential in the regulation of murine erythroleukemia cell differentiation.
PubMed Identifier: 6807553
author list: Levenson R, Macara IG, Smith RL, Cantley L, Housman D
published in: Cell
information resource reference: Role of mitochondrial membrane potential in the regulation of murine erythroleukemia cell differentiation. Cell. 1982 Apr; 28(4):855-63.
journal title abbreviation: Cell
publication date: 1982-04-01T00:00:00
year: 1982
type: Academic Article
type: Article
type: Document
type: Information Resource

Mechanism of anion exchange across the red cell membrane by band 3: interactions between stilbenedisulfonate and NAP-taurine binding sites.
PubMed Identifier: 7295699
author list: Macara IG, Cantley LC
published in: Biochemistry
information resource reference: Mechanism of anion exchange across the red cell membrane by band 3: interactions between stilbenedisulfonate and NAP-taurine binding sites. Biochemistry. 1981 Sep 29; 20(20):5695-701.
journal title abbreviation: Biochemistry
publication date: 1981-09-29T00:00:00
year: 1981
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA-ligand interaction.
PubMed Identifier: 8294866
author list: Kanakaraj P, Duckworth B, Azzoni L, Kamoun M, Cantley LC, Perussia B
published in: The Journal of experimental medicine
information resource reference: Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA-ligand interaction. J Exp Med. 1994 Feb 01; 179(2):551-8.
journal title abbreviation: J Exp Med
publication date: 1994-02-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins.
PubMed Identifier: 8521499
author list: Rameh LE, Chen CS, Cantley LC
published in: Cell
information resource reference: Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins. Cell. 1995 Dec 01; 83(5):821-30.
journal title abbreviation: Cell
publication date: 1995-12-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.
PubMed Identifier: 10497131
author list: Aramburu J, Yaffe MB, López-Rodríguez C, Cantley LC, Hogan PG, Rao A
published in: Science (New York, N.Y.)
information resource reference: Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science. 1999 Sep 24; 285(5436):2129-33.
journal title abbreviation: Science
publication date: 1999-09-24T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly.
PubMed Identifier: 10679324
author list: Tolias KF, Hartwig JH, Ishihara H, Shibasaki Y, Cantley LC, Carpenter CL
published in: Current biology : CB
information resource reference: Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly. Curr Biol. 2000 Feb 10; 10(3):153-6.
journal title abbreviation: Curr Biol
publication date: 2000-02-10T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Kinetic analysis of guanosine 5'-O-(3-thiotriphosphate) effects on phosphatidylinositol turnover in NRK cell homogenates.
PubMed Identifier: 3548823
author list: Chahwala SB, Fleischman LF, Cantley L
published in: Biochemistry
information resource reference: Kinetic analysis of guanosine 5'-O-(3-thiotriphosphate) effects on phosphatidylinositol turnover in NRK cell homogenates. Biochemistry. 1987 Jan 27; 26(2):612-22.
journal title abbreviation: Biochemistry
publication date: 1987-01-27T00:00:00
year: 1987
type: Academic Article
type: Article
type: Document
type: Information Resource

Activation of beef heart mitochondrial adenosine triphosphatase by 2,4-dinitrophenol.
PubMed Identifier: 4271561
author list: Cantley LC, Hammes GG
published in: Biochemistry
information resource reference: Activation of beef heart mitochondrial adenosine triphosphatase by 2,4-dinitrophenol. Biochemistry. 1973 Nov 20; 12(24):4900-4.
journal title abbreviation: Biochemistry
publication date: 1973-11-20T00:00:00
year: 1973
type: Academic Article
type: Article
type: Document
type: Information Resource

Characterization of the ATP-dependent proton pump of clathrin-coated vesicles.
PubMed Identifier: 6145711
author list: Forgac M, Cantley L
published in: The Journal of biological chemistry
information resource reference: Characterization of the ATP-dependent proton pump of clathrin-coated vesicles. J Biol Chem. 1984 Jul 10; 259(13):8101-5.
journal title abbreviation: J Biol Chem
publication date: 1984-07-10T00:00:00
year: 1984
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase.
PubMed Identifier: 7493994
author list: Toker A, Bachelot C, Chen CS, Falck JR, Hartwig JH, Cantley LC, Kovacsovics TJ
published in: The Journal of biological chemistry
information resource reference: Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase. J Biol Chem. 1995 Dec 08; 270(49):29525-31.
journal title abbreviation: J Biol Chem
publication date: 1995-12-08T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 135122
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Development of an intracellularly acting inhibitory peptide selective for PKN.

Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin.
PubMed Identifier: 7592789
author list: Kapeller R, Toker A, Cantley LC, Carpenter CL
published in: The Journal of biological chemistry
information resource reference: Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin. J Biol Chem. 1995 Oct 27; 270(43):25985-91.
journal title abbreviation: J Biol Chem
publication date: 1995-10-27T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of c-Src tyrosine kinase activity by the Src SH2 domain.
PubMed Identifier: 7683128
author list: Liu X, Brodeur SR, Gish G, Songyang Z, Cantley LC, Laudano AP, Pawson T
published in: Oncogene
information resource reference: Regulation of c-Src tyrosine kinase activity by the Src SH2 domain. Oncogene. 1993 May; 8(5):1119-26.
journal title abbreviation: Oncogene
publication date: 1993-05-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 118125
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Pathways for phosphoinositide synthesis.

Phosphoinositide 3-kinase in immunological systems.
PubMed Identifier: 11884226
author list: Fruman DA, Cantley LC
published in: Seminars in immunology
information resource reference: Phosphoinositide 3-kinase in immunological systems. Semin Immunol. 2002 Feb; 14(1):7-18.
journal title abbreviation: Semin Immunol
publication date: 2002-02-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation.
PubMed Identifier: 12876217
author list: Woolsey AM, Sunwoo L, Petersen CA, Brachmann SM, Cantley LC, Burleigh BA
published in: Journal of cell science
information resource reference: Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation. J Cell Sci. 2003 Sep 01; 116(Pt 17):3611-22.
journal title abbreviation: J Cell Sci
publication date: 2003-07-22T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.
PubMed Identifier: 15713674
author list: Fernandes N, Sun Y, Chen S, Paul P, Shaw RJ, Cantley LC, Price BD
published in: The Journal of biological chemistry
information resource reference: DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM. J Biol Chem. 2005 Apr 15; 280(15):15158-64.
journal title abbreviation: J Biol Chem
publication date: 2005-02-15T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Increasing the intracellular Na+ concentration induces differentiation in a pre-B lymphocyte cell line.
PubMed Identifier: 6608724
author list: Rosoff PM, Cantley LC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Increasing the intracellular Na+ concentration induces differentiation in a pre-B lymphocyte cell line. Proc Natl Acad Sci U S A. 1983 Dec; 80(24):7547-50.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1983-12-01T00:00:00
year: 1983
type: Academic Article
type: Article
type: Document
type: Information Resource

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.
PubMed Identifier: 7511210
author list: Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T
published in: Molecular and cellular biology
information resource reference: Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol Cell Biol. 1994 Apr; 14(4):2777-85.
journal title abbreviation: Mol Cell Biol
publication date: 1994-04-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Heregulin stimulates mitogenesis and phosphatidylinositol 3-kinase in mouse fibroblasts transfected with erbB2/neu and erbB3.
PubMed Identifier: 7535767
author list: Carraway KL, Soltoff SP, Diamonti AJ, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Heregulin stimulates mitogenesis and phosphatidylinositol 3-kinase in mouse fibroblasts transfected with erbB2/neu and erbB3. J Biol Chem. 1995 Mar 31; 270(13):7111-6.
journal title abbreviation: J Biol Chem
publication date: 1995-03-31T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.
PubMed Identifier: 8394019
author list: Prasad KV, Janssen O, Kapeller R, Raab M, Cantley LC, Rudd CE
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells. Proc Natl Acad Sci U S A. 1993 Aug 01; 90(15):7366-70.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1993-08-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 123890
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Purification and characterization of phosphoinositide 3-kinase from rat liver.

Structural changes in (Na+ + K+)-ATPase accompanying detergent inactivation.
PubMed Identifier: 6250591
author list: Powell LD, Cantley LC
published in: Biochimica et biophysica acta
information resource reference: Structural changes in (Na+ + K+)-ATPase accompanying detergent inactivation. Biochim Biophys Acta. 1980 Jul; 599(2):436-47.
journal title abbreviation: Biochim Biophys Acta
publication date: 1980-07-01T00:00:00
year: 1980
type: Academic Article
type: Article
type: Document
type: Information Resource

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling.
PubMed Identifier: 7845468
author list: Songyang Z, Carraway KL, Eck MJ, Harrison SC, Feldman RA, Mohammadi M, Schlessinger J, Hubbard SR, Smith DP, Eng C
published in: Nature
information resource reference: Catalytic specificity of protein-tyrosine kinases is critical for selective signalling. Nature. 1995 Feb 09; 373(6514):536-9.
journal title abbreviation: Nature
publication date: 1995-02-09T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling.
PubMed Identifier: 8033211
author list: Carraway KL, Cantley LC
published in: Cell
information resource reference: A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling. Cell. 1994 Jul 15; 78(1):5-8.
journal title abbreviation: Cell
publication date: 1994-07-15T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase.
PubMed Identifier: 8294442
author list: Kapeller R, Prasad KV, Janssen O, Hou W, Schaffhausen BS, Rudd CE, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase. J Biol Chem. 1994 Jan 21; 269(3):1927-33.
journal title abbreviation: J Biol Chem
publication date: 1994-01-21T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Biochemistry. PI3K charges ahead.
PubMed Identifier: 17626872
author list: Lee JY, Engelman JA, Cantley LC
published in: Science (New York, N.Y.)
information resource reference: Biochemistry. PI3K charges ahead. Science. 2007 Jul 13; 317(5835):206-7.
journal title abbreviation: Science
publication date: 2007-07-13T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Mitogens and ion fluxes.
PubMed Identifier: 2454071
author list: Soltoff SP, Cantley LC
published in: Annual review of physiology
information resource reference: Mitogens and ion fluxes. Annu Rev Physiol. 1988; 50:207-23.
journal title abbreviation: Annu Rev Physiol
publication date: 1988-01-01T00:00:00
year: 1988
type: Academic Article
type: Article
type: Document
type: Information Resource

Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation.
PubMed Identifier: 2825654
author list: Whitman M, Kaplan D, Roberts T, Cantley L
published in: The Biochemical journal
information resource reference: Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation. Biochem J. 1987 Oct 01; 247(1):165-74.
journal title abbreviation: Biochem J
publication date: 1987-10-01T00:00:00
year: 1987
type: Academic Article
type: Article
type: Document
type: Information Resource

Influence of threonine metabolism on S-adenosylmethionine and histone methylation.
PubMed Identifier: 23118012
author list: Shyh-Chang N, Locasale JW, Lyssiotis CA, Zheng Y, Teo RY, Ratanasirintrawoot S, Zhang J, Onder T, Unternaehrer JJ, Zhu H, Asara JM, Daley GQ, Cantley LC
published in: Science (New York, N.Y.)
information resource reference: Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science. 2013 Jan 11; 339(6116):222-6.
journal title abbreviation: Science
publication date: 2012-11-01T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 119369
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Binding specificity and mutational analysis of the phosphotyrosine binding domain of the brain-specific adaptor protein ShcC.

Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit.
PubMed Identifier: 7683653
author list: Carpenter CL, Auger KR, Chanudhuri M, Yoakim M, Schaffhausen B, Shoelson S, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit. J Biol Chem. 1993 May 05; 268(13):9478-83.
journal title abbreviation: J Biol Chem
publication date: 1993-05-05T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Characterization of nucleotide binding sites on chloroplast coupling factor 1.
PubMed Identifier: 1148187
author list: Cantley LC, Hammes GG
published in: Biochemistry
information resource reference: Characterization of nucleotide binding sites on chloroplast coupling factor 1. Biochemistry. 1975 Jul; 14(13):2968-75.
journal title abbreviation: Biochemistry
publication date: 1975-07-01T00:00:00
year: 1975
type: Academic Article
type: Article
type: Document
type: Information Resource

https://connects.catalyst.harvard.edu/Profiles/profile/1160211
PubMed Identifier: 8621719
author list: Panchamoorthy G, Fukazawa T, Miyake S, Soltoff S, Reedquist K, Druker B, Shoelson S, Cantley L, Band H
published in: The Journal of biological chemistry
information resource reference: p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase. J Biol Chem. 1996 Feb 09; 271(6):3187-94.
journal title abbreviation: J Biol Chem
publication date: 1996-02-09T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource
label: p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase.

The inositol 5'-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation.
PubMed Identifier: 8910587
author list: Osborne MA, Zenner G, Lubinus M, Zhang X, Songyang Z, Cantley LC, Majerus P, Burn P, Kochan JP
published in: The Journal of biological chemistry
information resource reference: The inositol 5'-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation. J Biol Chem. 1996 Nov 15; 271(46):29271-8.
journal title abbreviation: J Biol Chem
publication date: 1996-11-15T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphoinositide binding domains: embracing 3-phosphate.
PubMed Identifier: 10399908
author list: Fruman DA, Rameh LE, Cantley LC
published in: Cell
information resource reference: Phosphoinositide binding domains: embracing 3-phosphate. Cell. 1999 Jun 25; 97(7):817-20.
journal title abbreviation: Cell
publication date: 1999-06-25T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation.
PubMed Identifier: 10917654
author list: Fruman DA, Snapper SB, Yballe CM, Alt FW, Cantley LC
published in: Biochemical Society transactions
information resource reference: Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation. Biochem Soc Trans. 1999 Aug; 27(4):624-9.
journal title abbreviation: Biochem Soc Trans
publication date: 1999-08-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries.
PubMed Identifier: 11075345
author list: Yaffe MB, Cantley LC
published in: Methods in enzymology
information resource reference: Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries. Methods Enzymol. 2000; 328:157-70.
journal title abbreviation: Methods Enzymol
publication date: 2000-01-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

The PX domains of p47phox and p40phox bind to lipid products of PI(3)K.
PubMed Identifier: 11433300
author list: Kanai F, Liu H, Field SJ, Akbary H, Matsuo T, Brown GE, Cantley LC, Yaffe MB
published in: Nature cell biology
information resource reference: The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nat Cell Biol. 2001 Jul; 3(7):675-8.
journal title abbreviation: Nat Cell Biol
publication date: 2001-07-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase.
PubMed Identifier: 11752399
author list: Ueki K, Yballe CM, Brachmann SM, Vicent D, Watt JM, Kahn CR, Cantley LC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):419-24.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2001-12-18T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Oncogenes and signal transduction.
PubMed Identifier: 1846320
author list: Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff S
published in: Cell
information resource reference: Oncogenes and signal transduction. Cell. 1991 Jan 25; 64(2):281-302.
journal title abbreviation: Cell
publication date: 1991-01-25T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms.
PubMed Identifier: 15199048
author list: Williamson AL, Lecchi P, Turk BE, Choe Y, Hotez PJ, McKerrow JH, Cantley LC, Sajid M, Craik CS, Loukas A
published in: The Journal of biological chemistry
information resource reference: A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. J Biol Chem. 2004 Aug 20; 279(34):35950-7.
journal title abbreviation: J Biol Chem
publication date: 2004-06-15T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

The negative regulation of phosphoinositide 3-kinase signaling by p85 and it's implication in cancer.
PubMed Identifier: 16131837
author list: Luo J, Cantley LC
published in: Cell cycle (Georgetown, Tex.)
information resource reference: The negative regulation of phosphoinositide 3-kinase signaling by p85 and it's implication in cancer. Cell Cycle. 2005 Oct; 4(10):1309-12.
journal title abbreviation: Cell Cycle
publication date: 2005-10-28T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells.
PubMed Identifier: 16322248
author list: Isakoff SJ, Engelman JA, Irie HY, Luo J, Brachmann SM, Pearline RV, Cantley LC, Brugge JS
published in: Cancer research
information resource reference: Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res. 2005 Dec 01; 65(23):10992-1000.
journal title abbreviation: Cancer Res
publication date: 2005-12-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.
PubMed Identifier: 16417406
author list: Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW
published in: PLoS biology
information resource reference: Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol. 2006 Feb; 4(2):e38.
journal title abbreviation: PLoS Biol
publication date: 2006-01-24T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.
PubMed Identifier: 17463250
author list: Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, Lindeman N, Gale CM, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, Cappuzzo F, Mok T, Lee C, Johnson BE, Cantley LC, Jänne PA
published in: Science (New York, N.Y.)
information resource reference: MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007 May 18; 316(5827):1039-43.
journal title abbreviation: Science
publication date: 2007-04-26T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Somatic mutations of PIK3R1 promote gliomagenesis.
PubMed Identifier: 23166678
author list: Quayle SN, Lee JY, Cheung LW, Ding L, Wiedemeyer R, Dewan RW, Huang-Hobbs E, Zhuang L, Wilson RK, Ligon KL, Mills GB, Cantley LC, Chin L
published in: PloS one
information resource reference: Somatic mutations of PIK3R1 promote gliomagenesis. PLoS One. 2012; 7(11):e49466.
journal title abbreviation: PLoS One
publication date: 2012-11-14T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of CDCP1 as a hypoxia-inducible factor 2a (HIF-2a) target gene that is associated with survival in clear cell renal cell carcinoma patients.
PubMed Identifier: 23378636
author list: Emerling BM, Benes CH, Poulogiannis G, Bell EL, Courtney K, Liu H, Choo-Wing R, Bellinger G, Tsukazawa KS, Brown V, Signoretti S, Soltoff SP, Cantley LC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Identification of CDCP1 as a hypoxia-inducible factor 2a (HIF-2a) target gene that is associated with survival in clear cell renal cell carcinoma patients. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3483-8.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2013-02-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Hypothalamic sodium-transport inhibitor is a high-affinity reversible inhibitor of Na+-K+-ATPase.
PubMed Identifier: 6095682
author list: Haupert GT, Carilli CT, Cantley LC
published in: The American journal of physiology
information resource reference: Hypothalamic sodium-transport inhibitor is a high-affinity reversible inhibitor of Na+-K+-ATPase. Am J Physiol. 1984 Dec; 247(6 Pt 2):F919-24.
journal title abbreviation: Am J Physiol
publication date: 1984-12-01T00:00:00
year: 1984
type: Academic Article
type: Article
type: Document
type: Information Resource

Inositol 1,4,5-trisphosphate stimulates phosphorylation of a 62,000-dalton protein in monkey fibroblast and bovine brain cell lysates.
PubMed Identifier: 6438079
author list: Whitman MR, Epstein J, Cantley L
published in: The Journal of biological chemistry
information resource reference: Inositol 1,4,5-trisphosphate stimulates phosphorylation of a 62,000-dalton protein in monkey fibroblast and bovine brain cell lysates. J Biol Chem. 1984 Nov 25; 259(22):13652-5.
journal title abbreviation: J Biol Chem
publication date: 1984-11-25T00:00:00
year: 1984
type: Academic Article
type: Article
type: Document
type: Information Resource

Amiloride inhibits murine erythroleukemia cell differentiation: evidence for a Ca2+ requirement for commitment.
PubMed Identifier: 6934526
author list: Levenson R, Housman D, Cantley L
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Amiloride inhibits murine erythroleukemia cell differentiation: evidence for a Ca2+ requirement for commitment. Proc Natl Acad Sci U S A. 1980 Oct; 77(10):5948-52.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1980-10-01T00:00:00
year: 1980
type: Academic Article
type: Article
type: Document
type: Information Resource

Evidence that a Na+/Ca2+ antiport system regulates murine erythroleukemia cell differentiation.
PubMed Identifier: 7054181
author list: Smith RL, Macara IG, Levenson R, Housman D, Cantley L
published in: The Journal of biological chemistry
information resource reference: Evidence that a Na+/Ca2+ antiport system regulates murine erythroleukemia cell differentiation. J Biol Chem. 1982 Jan 25; 257(2):773-80.
journal title abbreviation: J Biol Chem
publication date: 1982-01-25T00:00:00
year: 1982
type: Academic Article
type: Article
type: Document
type: Information Resource

Use of an oriented peptide library to determine the optimal substrates of protein kinases.
PubMed Identifier: 7874496
author list: Songyang Z, Blechner S, Hoagland N, Hoekstra MF, Piwnica-Worms H, Cantley LC
published in: Current biology : CB
information resource reference: Use of an oriented peptide library to determine the optimal substrates of protein kinases. Curr Biol. 1994 Nov 01; 4(11):973-82.
journal title abbreviation: Curr Biol
publication date: 1994-11-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression.
PubMed Identifier: 7935461
author list: Jhun BH, Rose DW, Seely BL, Rameh L, Cantley L, Saltiel AR, Olefsky JM
published in: Molecular and cellular biology
information resource reference: Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression. Mol Cell Biol. 1994 Nov; 14(11):7466-75.
journal title abbreviation: Mol Cell Biol
publication date: 1994-11-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D.
PubMed Identifier: 8063770
author list: Liscovitch M, Chalifa V, Pertile P, Chen CS, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D. J Biol Chem. 1994 Aug 26; 269(34):21403-6.
journal title abbreviation: J Biol Chem
publication date: 1994-08-26T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeleton.
PubMed Identifier: 8413207
author list: Kapeller R, Chakrabarti R, Cantley L, Fay F, Corvera S
published in: Molecular and cellular biology
information resource reference: Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeleton. Mol Cell Biol. 1993 Oct; 13(10):6052-63.
journal title abbreviation: Mol Cell Biol
publication date: 1993-10-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 115597
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Phosphoinositide metabolism and the control of cell proliferation.

Authorship 110503
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D.

Authorship 115925
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit.

Phosphatidylinositol 3-Kinases
MeSH DescriptorUI: D019869
MeSH semantic group name: Chemicals & Drugs
number of authors: 1119
number of publications: 2875
uniqueness weight: 0.509007
type: Concept

Phosphotransferases
MeSH DescriptorUI: D010770
MeSH semantic group name: Chemicals & Drugs
number of authors: 159
number of publications: 299
uniqueness weight: 0.906579
type: Concept

Phosphatidylinositol Phosphates
MeSH DescriptorUI: D018129
MeSH semantic group name: Chemicals & Drugs
number of authors: 102
number of publications: 213
uniqueness weight: 0.910324
type: Concept

Phosphotransferases (Alcohol Group Acceptor)
MeSH DescriptorUI: D017853
MeSH semantic group name: Chemicals & Drugs
number of authors: 211
number of publications: 437
uniqueness weight: 0.822665
type: Concept

Phosphatidylinositols
MeSH DescriptorUI: D010716
MeSH semantic group name: Chemicals & Drugs
number of authors: 137
number of publications: 273
uniqueness weight: 0.907816
type: Concept

Cell Biology
type: Department
type: Organization

Genetics
type: Department
type: Organization

Medicine
type: Department
type: Organization

Pathology
type: Department
type: Organization

Radiation Oncology
type: Department
type: Organization

Surgery
type: Department
type: Organization

Signal Transduction
type: Division
type: Organization

Joslin
type: Division
type: Organization

Oncology
type: Division
type: Organization

Beth Israel Deaconess Medical Center
type: Organization

Brigham and Women's Hospital
type: Organization

Dana-Farber Cancer Institute
type: Organization

Harvard Medical School
type: Organization

Harvard T.H. Chan School of Public Health
type: Organization

Joslin Diabetes Center
type: Organization

Toker, Alex
eCommons Login: AT14
first name: Alex
last name: Toker
full name: Alex Toker, Ph.D.
has faculty rank: Full Professor
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longitude: -71.10585400000000
Person ID: 84340
person in primary position: Professor of Pathology
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type: Person
preferred title: Professor of Pathology

Schlechter, Benjamin
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first name: Benjamin
last name: Schlechter
full name: Benjamin Louis Schlechter, M.D.
has faculty rank: Assistant Professor
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longitude: -71.10585400000000
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Person ID: 32534
person in primary position: Assistant Professor of Medicine
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preferred title: Assistant Professor of Medicine

Yurgelun, Matthew
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first name: Matthew
last name: Yurgelun
full name: Matthew Boland Yurgelun, M.D.
has faculty rank: Associate Professor
latitude: 42.34022770000000
longitude: -71.10585400000000
Person ID: 71749
person in primary position: Associate Professor of Medicine
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type: Person
preferred title: Associate Professor of Medicine

Manning, Brendan
eCommons Login: BDM2
first name: Brendan
last name: Manning
full name: Brendan D. Manning, Ph.D.
has faculty rank: Full Professor
latitude: 42.33570000000000
longitude: -71.10169990000000
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Person ID: 50703
person in primary position: Barry R. and Irene T. Bloom Professorship of Public Health
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preferred title: Barry R. and Irene T. Bloom Professorship of Public Health

Konstantinopoulos, Panagiotis
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first name: Panagiotis
last name: Konstantinopoulos
full name: Panagiotis Konstantinopoulos, M.D., Ph.D.
has faculty rank: Full Professor
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longitude: -71.10585400000000
Person ID: 55714
person in primary position: Professor of Medicine
type: Agent
type: Person
preferred title: Professor of Medicine

Stevenson, Mary
eCommons Login: MAS8
first name: Mary
last name: Stevenson
full name: Mary Ann Stevenson, M.D.,Ph.D.
has faculty rank: Associate Professor
latitude: 42.34022770000000
longitude: -71.10585400000000
Person ID: 34376
person in primary position: Associate Professor of Radiation Oncology
type: Agent
type: Person
preferred title: Associate Professor of Radiation Oncology

selected publications
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research areas
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Elledge, Stephen
eCommons Login: SJE2
first name: Stephen
last name: Elledge
full name: Stephen J. Elledge, Ph.D.
has faculty rank: Full Professor
latitude: 42.33837200000000
longitude: -71.10326900000000
Person ID: 32424
person in primary position: Gregor Mendel Professor of Genetics and of Medicine
type: Agent
type: Person
preferred title: Gregor Mendel Professor of Genetics and of Medicine

Authorship 122234
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Minimal activators that bind to the KIX domain of p300/CBP identified by phage display screening.

Slater, Sarah
eCommons Login: SES26
first name: Sarah
last name: Slater
full name: Sarah Elizabeth Slater, M.D.
has faculty rank: Assistant Professor
latitude: 42.34022770000000
longitude: -71.10585400000000
Person ID: 36214
person in primary position: Assistant Professor of Medicine
type: Agent
type: Person
preferred title: Assistant Professor of Medicine

Gygi, Steven
eCommons Login: SPG4
first name: Steven
last name: Gygi
full name: Steven P. Gygi, Ph.D.
has faculty rank: Full Professor
latitude: 42.33588600000000
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Person ID: 28969
person in primary position: Professor of Cell Biology
type: Agent
type: Person
preferred title: Professor of Cell Biology

Authorship 148501
type: Authorship
author rank in publication: 15
linked author: Cantley, Lewis
linked information resource: Identification of small molecule inhibitors of anthrax lethal factor.

Vander Heiden, Matthew
eCommons Login: MGV4
first name: Matthew
last name: Vander Heiden
full name: Matthew George Vander Heiden, M.D., Ph.D.
has faculty rank: Instructor
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Person ID: 65872
person in primary position: Instructor in Medicine
type: Agent
type: Person
preferred title: Instructor in Medicine

Kahn, C.
eCommons Login: CRK3
first name: C.
last name: Kahn
full name: C. Ronald Kahn, M.D.
has faculty rank: Full Professor
latitude: 42.33839600000000
longitude: -71.10840300000000
Person ID: 84269
person in primary position: Mary K. Iacocca Professor of Medicine
type: Agent
type: Person
preferred title: Mary K. Iacocca Professor of Medicine

Yaffe, Michael
eCommons Login: MBY1
first name: Michael
last name: Yaffe
full name: Michael Bruce Yaffe, M.D., Ph.D.
has faculty rank: Instructor
latitude: 42.36019290000000
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Person ID: 26854
person in primary position: Instructor in Surgery
type: Agent
type: Person
preferred title: Instructor in Surgery

Authorship 134053
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Covalent reactions of wortmannin under physiological conditions.

Perrimon, Norbert
eCommons Login: NP7
first name: Norbert
last name: Perrimon
full name: Norbert Perrimon, Ph.D.
has faculty rank: Full Professor
latitude: 42.33837200000000
longitude: -71.10326900000000
Person ID: 6247
person in primary position: James Stillman Professor of Developmental Biology
type: Agent
type: Person
preferred title: James Stillman Professor of Developmental Biology

Asara, John
eCommons Login: JMA22
first name: John
last name: Asara
full name: John M Asara, Ph.D.
has faculty rank: Associate Professor
latitude: 42.33849900000000
longitude: -71.10446000000000
photo: https://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 88579
person in primary position: Associate Professor of Medicine
type: Agent
type: Person
preferred title: Associate Professor of Medicine

Authorship 154337
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor.

Authorship 157835
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates.

Authorship 158224
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation.

Authorship 110779
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Two distinct cytosolic calcium responses to extracellular ATP in rat parotid acinar cells.

Authorship 15705
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Phosphatidylinositol 3-kinase confers resistance to encephalomyocarditis and herpes simplex virus-induced cell death through the activation of distinct downstream effectors.

Instructor in Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Instructor in Medicine
position in organization: Dana-Farber Cancer Institute

Associate Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Signal Transduction
sort order: 1
type: Position
HR job title: Associate Professor of Medicine
position in organization: Beth Israel Deaconess Medical Center

Authorship 141586
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway.

Authorship 141405
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.

Authorship 16271
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: In-Gel Stable-Isotope Labeling (ISIL): a strategy for mass spectrometry-based relative quantification.

Authorship 121131
type: Authorship
author rank in publication: 13
linked author: Cantley, Lewis
linked information resource: Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.

Authorship 162714
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Novel polyphosphoinositides in cell growth and activation.

Authorship 15622
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: SH2 domain specificity determination using oriented phosphopeptide library.

Authorship 130509
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Targeting the PI3K signaling pathway in cancer.

Authorship 175186
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation.

Authorship 181790
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: Class 1A PI3K regulates vessel integrity during development and tumorigenesis.

Authorship 141883
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Expression of an ouabain-resistant Na,K-ATPase in CV-1 cells after transfection with a cDNA encoding the rat Na,K-ATPase alpha 1 subunit.

Authorship 146173
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: ras-transformed cells: altered levels of phosphatidylinositol-4,5-bisphosphate and catabolites.

Authorship 136685
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: Large-scale characterization of HeLa cell nuclear phosphoproteins.

Authorship 15677
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Effects of muscarinic, alpha-adrenergic, and substance P agonists and ionomycin on ion transport mechanisms in the rat parotid acinar cell. The dependence of ion transport on intracellular calcium.

Authorship 165530
type: Authorship
author rank in publication: 9
linked author: Cantley, Lewis
linked information resource: Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes.

Professor of Cell Biology
is primary position: true
position in department: Cell Biology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Cell Biology
position in organization: Harvard Medical School

Authorship 136401
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin.

Molecular Metabolism
type: Department
type: Organization

Authorship 188869
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation.

Authorship 138182
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin.

Authorship 243444
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26.

Authorship 224010
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif.

Authorship 199384
type: Authorship
author rank in publication: 10
linked author: Cantley, Lewis
linked information resource: The antiproliferative cytostatic effects of a self-activating viridin prodrug.

Authorship 151652
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: Fluorescence energy transfer between ligand binding sites on chloroplast coupling factor 1.

Authorship 153058
type: Authorship
author rank in publication: 14
linked author: Cantley, Lewis
linked information resource: Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis.

Authorship 144322
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Characterization of a Rac1- and RhoGDI-associated lipid kinase signaling complex.

Authorship 16648
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: PI3K enters beta-testing.

Authorship 176127
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: The SH2 domain-containing inositol 5'-phosphatase (SHIP) recruits the p85 subunit of phosphoinositide 3-kinase during FcgammaRIIb1-mediated inhibition of B cell receptor signaling.

Authorship 179709
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Signalling through the lipid products of phosphoinositide-3-OH kinase.

Authorship 195204
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins.

Authorship 190935
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells.

Authorship 163416
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes.

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.
PubMed Identifier: 23663782
author list: Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, Blenis J
published in: Cell
information resource reference: The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 2013 May 09; 153(4):840-54.
journal title abbreviation: Cell
publication date: 2013-05-09T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 211536
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi.

Authorship 254194
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice.

Authorship 287557
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Phosphoinositide 3-kinase in immunological systems.

Authorship 290846
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Evidence that a Na+/Ca2+ antiport system regulates murine erythroleukemia cell differentiation.

Authorship 29113
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly.

Authorship 362936
type: Authorship
author rank in publication: 13
linked author: Cantley, Lewis
linked information resource: A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains.

Authorship 3735
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate.

Authorship 172170
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Extracellular ATP induces ion fluxes and inhibits growth of Friend erythroleukemia cells.

Professor of Cell Biology
is primary position: true
position in department: Cell Biology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Cell Biology
position in organization: Dana-Farber Cancer Institute

Authorship 415512
type: Authorship
author rank in publication: 15
linked author: Cantley, Lewis
linked information resource: Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer.

Authorship 424842
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.

Role of Phosphoinositides and Protein Kinases in the control of Cancer Metabolism
end date: 2031-07-31
principal investigator name: CANTLEY, LEWIS C.
start date: 2016-09-05
type: Grant
sponsor award id: R35CA197588

MECHANISM OF CATION TRANSPORT REGULATION
end date: 1994-01-31
principal investigator name: CANTLEY, LEWIS C
start date: 1985-05-01
type: Grant
sponsor award id: R01GM036133

Characterization of Phosphatidylinositol Kinases
end date: 2009-09-30
principal investigator name: CANTLEY, LEWIS C
start date: 1986-07-01
type: Grant
sponsor award id: R01GM036624

The Role of PI3K in Growth Regulation
end date: 2017-05-31
principal investigator name: CANTLEY, LEWIS C.
start date: 1990-04-01
type: Grant
sponsor award id: R01GM041890

Center on the Physics of Cancer Metabolism
end date: 2021-07-31
principal investigator name: FISCHBACH, CLAUDIA
start date: 2016-08-29
type: Grant
sponsor award id: U54CA210184

Protein Kinase Signaling Pathways
end date: 2013-06-30
principal investigator name: CANTLEY, LEWIS C.
start date: 1997-07-01
type: Grant
sponsor award id: R01GM056203

FUNCTION OF THE ATAXIA TELANGIECTASIA GENE PRODUCT
end date: 2003-03-31
principal investigator name: CANTLEY, LEWIS C
start date: 1998-01-01
type: Grant
sponsor award id: R01GM057018

STRUCTURE AND MECHANISM OF MEMBRANE TRANSPORT SYSTEMS
end date: 1987-03-31
principal investigator name: CANTLEY, LEWIS C
start date: 1985-04-01
type: Grant
sponsor award id: R01GM035912

MECHANISM OF CATION TRANSPORT REGULATION
end date: 1985-04-30
principal investigator name: CANTLEY, LEWIS C
start date: 1981-02-01
type: Grant
sponsor award id: R01GM028538

PHOSPHATDYLINOSITOL-3-P AND GROWTH REGULATION
end date: 2009-03-31
principal investigator name: CANTLEY, LEWIS C
start date: 1995-04-01
type: Grant
sponsor award id: R37GM041890

Co-Principal Investigator
type: Researcher Role
researcher role of: Cantley, Lewis
contributes to: Center on the Physics of Cancer Metabolism

Principal Investigator
type: Researcher Role
researcher role of: Cantley, Lewis
contributes to: Role of Phosphoinositides and Protein Kinases in the control of Cancer Metabolism

Principal Investigator
type: Researcher Role
researcher role of: Cantley, Lewis
contributes to: SCOR IN MOLECULAR MEDICINE AND ATHEROSCLEROSIS

Principal Investigator
type: Researcher Role
researcher role of: Cantley, Lewis
contributes to: Characterization of Phosphatidylinositol Kinases

Principal Investigator
type: Researcher Role
researcher role of: Cantley, Lewis
contributes to: The Role of PTEN and the PI3K Pathway in Prostate Cancer

Principal Investigator
type: Researcher Role
researcher role of: Cantley, Lewis
contributes to: Protein Kinase Signaling Pathways

Principal Investigator
type: Researcher Role
researcher role of: Cantley, Lewis
contributes to: FUNCTION OF THE ATAXIA TELANGIECTASIA GENE PRODUCT

Principal Investigator
type: Researcher Role
researcher role of: Cantley, Lewis
contributes to: STRUCTURE AND MECHANISM OF MEMBRANE TRANSPORT SYSTEMS

Principal Investigator
type: Researcher Role
researcher role of: Cantley, Lewis
contributes to: PHOSPHATDYLINOSITOL-3-P AND GROWTH REGULATION

Principal Investigator
type: Researcher Role
researcher role of: Cantley, Lewis
contributes to: The Role of PI3K in Growth Regulation

Principal Investigator
type: Researcher Role
researcher role of: Cantley, Lewis
contributes to: MECHANISM OF CATION TRANSPORT REGULATION

Principal Investigator
type: Researcher Role
researcher role of: Cantley, Lewis
contributes to: MECHANISM OF CATION TRANSPORT REGULATION

Authorship 426025
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.

Authorship 242082
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: In vivo near-infrared fluorescence imaging of osteoblastic activity.

Associate Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Associate Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Authorship 17309
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C.

Authorship 188179
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: The conserved phosphoinositide 3-kinase pathway determines heart size in mice.

Authorship 207528
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.

Authorship 471705
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex.

Authorship 265483
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase.

Authorship 333715
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation.

Authorship 342462
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Association of phosphatidylinositol 3-kinase, via the SH2 domains of p85, with focal adhesion kinase in polyoma middle t-transformed fibroblasts.

Authorship 375706
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Mouse phosphoinositide 3-kinase p110alpha gene: cloning, structural organization, and localization to chromosome 3 band B.

Authorship 153866
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase.

Authorship 397766
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.

Gregor Mendel Professor of Genetics and of Medicine
is primary position: true
position in department: Genetics
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Gregor Mendel Professor of Genetics and of Medicine
position in organization: Brigham and Women's Hospital

Associate Professor of Radiation Oncology
is primary position: true
position in department: Radiation Oncology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Associate Professor of Radiation Oncology
position in organization: Beth Israel Deaconess Medical Center

Authorship 438706
type: Authorship
author rank in publication: 12
linked author: Cantley, Lewis
linked information resource: Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.

Authorship 476636
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Ionic regulation of MEL cell commitment.

Authorship 510853
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Phosphatidylinositol 4,5-bisphosphate synthesis is required for activation of phospholipase D in U937 cells.

Authorship 512486
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.

Authorship 536895
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: Phosphatidylinositol metabolism and polyoma-mediated transformation.

Authorship 58579
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Association of protein kinase Cmu with type II phosphatidylinositol 4-kinase and type I phosphatidylinositol-4-phosphate 5-kinase.

Authorship 59226
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta.

Authorship 21841
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection.

Authorship 234615
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.

Authorship 258915
type: Authorship
author rank in publication: 9
linked author: Cantley, Lewis
linked information resource: The structural basis for 14-3-3:phosphopeptide binding specificity.

Authorship 259500
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: A sweet new role for EGFR in cancer.

Authorship 264704
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Cloning and characterization of a human phosphatidylinositol 4-kinase.

Authorship 307918
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: Specificity in protein-tyrosine kinase signaling.

Authorship 308278
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.

Authorship 353212
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: Specificity in recognition of phosphopeptides by src-homology 2 domains.

Authorship 380410
type: Authorship
linked author: Cantley, Lewis
linked information resource: Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

Authorship 382350
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape.

Authorship 382686
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: The negative regulation of phosphoinositide 3-kinase signaling by p85 and it's implication in cancer.

Assistant Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Assistant Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Mary K. Iacocca Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Joslin
sort order: 1
type: Position
HR job title: Mary K. Iacocca Professor of Medicine
position in organization: Joslin Diabetes Center

Professor of Pathology
is primary position: true
position in department: Pathology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Pathology
position in organization: Beth Israel Deaconess Medical Center

Instructor in Surgery
is primary position: true
position in department: Surgery
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Instructor in Surgery
position in organization: Beth Israel Deaconess Medical Center

Authorship 257010
type: Authorship
author rank in publication: 9
linked author: Cantley, Lewis
linked information resource: MMP-20 is predominately a tooth-specific enzyme with a deep catalytic pocket that hydrolyzes type V collagen.

Authorship 337165
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: The use of peptide library for the determination of kinase peptide substrates.

High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.
PubMed Identifier: 21984976
author list: Cheung LW, Hennessy BT, Li J, Yu S, Myers AP, Djordjevic B, Lu Y, Stemke-Hale K, Dyer MD, Zhang F, Ju Z, Cantley LC, Scherer SE, Liang H, Lu KH, Broaddus RR, Mills GB
published in: Cancer discovery
information resource reference: High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cancer Discov. 2011 Jul; 1(2):170-85.
journal title abbreviation: Cancer Discov
publication date: 2011-06-07T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations.
PubMed Identifier: 21256021
author list: Yuan TL, Wulf G, Burga L, Cantley LC
published in: Current biology : CB
information resource reference: Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations. Curr Biol. 2011 Feb 08; 21(3):173-83.
journal title abbreviation: Curr Biol
publication date: 2011-01-20T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9.
PubMed Identifier: 23589871
author list: Gallop JL, Walrant A, Cantley LC, Kirschner MW
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9. Proc Natl Acad Sci U S A. 2013 Apr 30; 110(18):7193-8.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2013-04-15T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Targeting a common collaborator in cancer development.
PubMed Identifier: 20826838
author list: Myers AP, Cantley LC
published in: Science translational medicine
information resource reference: Targeting a common collaborator in cancer development. Sci Transl Med. 2010 Sep 08; 2(48):48ps45.
journal title abbreviation: Sci Transl Med
publication date: 2010-09-08T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Stem cell metabolism in tissue development and aging.
PubMed Identifier: 23715547
author list: Shyh-Chang N, Daley GQ, Cantley LC
published in: Development (Cambridge, England)
information resource reference: Stem cell metabolism in tissue development and aging. Development. 2013 Jun; 140(12):2535-47.
journal title abbreviation: Development
publication date: 2013-06-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling.
PubMed Identifier: 23830207
author list: Song SJ, Poliseno L, Song MS, Ala U, Webster K, Ng C, Beringer G, Brikbak NJ, Yuan X, Cantley LC, Richardson AL, Pandolfi PP
published in: Cell
information resource reference: MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling. Cell. 2013 Jul 18; 154(2):311-324.
journal title abbreviation: Cell
publication date: 2013-07-03T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.
PubMed Identifier: 23727860
author list: Lunardi A, Ala U, Epping MT, Salmena L, Clohessy JG, Webster KA, Wang G, Mazzucchelli R, Bianconi M, Stack EC, Lis R, Patnaik A, Cantley LC, Bubley G, Cordon-Cardo C, Gerald WL, Montironi R, Signoretti S, Loda M, Nardella C, Pandolfi PP
published in: Nature genetics
information resource reference: A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer. Nat Genet. 2013 Jul; 45(7):747-55.
journal title abbreviation: Nat Genet
publication date: 2013-06-02T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 88403
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Interpreting sequences from mastodon and T. rex.

Authorship 96625
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: A novel pathway for the formation of phosphatidylinositol 3,4-bisphosphate. Phosphorylation of phosphatidylinositol 3-monophosphate by phosphatidylinositol-3-monophosphate 4-kinase.

Authorship 6859
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Hypothalamic factor inhibits the (Na,K)ATPase from the extracellular surface. Mechanism of inhibition.

Authorship 196964
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo.

Authorship 201423
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Ligand discrimination in signaling through an ErbB4 receptor homodimer.

Authorship 75719
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Use of an oriented peptide library to determine the optimal substrates of protein kinases.

Authorship 78734
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes.

Authorship 528131
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.

Authorship 560428
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Phosphoinositide kinases.

Authorship 561903
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.

Authorship 564501
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

Authorship 566621
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Cancer's insatiable appetite.

Authorship 58211
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Regulation of CD4-p56lck-associated phosphatidylinositol 3-kinase (PI 3-kinase) and phosphatidylinositol 4-kinase (PI 4-kinase).

Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Authorship 265714
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity.

Authorship 160864
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes.

Authorship 300483
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis.

Authorship 684490
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9.

Authorship 685740
type: Authorship
author rank in publication: 15
linked author: Cantley, Lewis
linked information resource: Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival.

Authorship 686215
type: Authorship
author rank in publication: 11
linked author: Cantley, Lewis
linked information resource: Evidence for an alternative glycolytic pathway in rapidly proliferating cells.

Authorship 687329
type: Authorship
author rank in publication: 22
linked author: Cantley, Lewis
linked information resource: Characterization of KRAS rearrangements in metastatic prostate cancer.

Authorship 684269
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.

Authorship 683936
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization.

Authorship 684113
type: Authorship
author rank in publication: 12
linked author: Cantley, Lewis
linked information resource: Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers.

Authorship 683946
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations.

Authorship 685036
type: Authorship
author rank in publication: 12
linked author: Cantley, Lewis
linked information resource: High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability.

Authorship 684297
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/845974

Authorship 686773
type: Authorship
author rank in publication: 13
linked author: Cantley, Lewis
linked information resource: Identification of CDCP1 as a hypoxia-inducible factor 2a (HIF-2a) target gene that is associated with survival in clear cell renal cell carcinoma patients.

Authorship 684586
type: Authorship
author rank in publication: 9
linked author: Cantley, Lewis
linked information resource: Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

Authorship 684118
type: Authorship
author rank in publication: 13
linked author: Cantley, Lewis
linked information resource: A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.

Authorship 685784
type: Authorship
author rank in publication: 30
linked author: Cantley, Lewis
linked information resource: Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

Authorship 686039
type: Authorship
author rank in publication: 12
linked author: Cantley, Lewis
linked information resource: AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.

Authorship 687605
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: I?B kinase a phosphorylation of TRAF4 downregulates innate immune signaling.

Authorship 686559
type: Authorship
author rank in publication: 13
linked author: Cantley, Lewis
linked information resource: The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.

Authorship 686609
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake.

Authorship 688693
type: Authorship
author rank in publication: 13
linked author: Cantley, Lewis
linked information resource: Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.

Authorship 688897
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: A fluorescent reporter of AMPK activity and cellular energy stress.

Authorship 685675
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Breathless cancer cells get fat on glutamine.

Authorship 685330
type: Authorship
author rank in publication: 9
linked author: Cantley, Lewis
linked information resource: Using tandem mass spectrometry in targeted mode to identify activators of class IA PI3K in cancer.

Authorship 687238
type: Authorship
author rank in publication: 10
linked author: Cantley, Lewis
linked information resource: MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling.

Authorship 686171
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Targeting a common collaborator in cancer development.

Authorship 685231
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Introduction.

Authorship 685787
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: p85a SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation.

Authorship 688877
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size.

Authorship 689715
type: Authorship
author rank in publication: 13
linked author: Cantley, Lewis
linked information resource: Systemic elevation of PTEN induces a tumor-suppressive metabolic state.

Authorship 688000
type: Authorship
author rank in publication: 12
linked author: Cantley, Lewis
linked information resource: Somatic mutations of PIK3R1 promote gliomagenesis.

Authorship 685799
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: SIRT6 puts cancer metabolism in the driver's seat.

Authorship 688667
type: Authorship
author rank in publication: 13
linked author: Cantley, Lewis
linked information resource: Influence of threonine metabolism on S-adenosylmethionine and histone methylation.

Authorship 688933
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Stem cell metabolism in tissue development and aging.

Authorship 687633
type: Authorship
author rank in publication: 9
linked author: Cantley, Lewis
linked information resource: Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.

Authorship 688437
type: Authorship
author rank in publication: 17
linked author: Cantley, Lewis
linked information resource: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

Characterization of KRAS rearrangements in metastatic prostate cancer.
PubMed Identifier: 22140652
author list: Wang XS, Shankar S, Dhanasekaran SM, Ateeq B, Sasaki AT, Jing X, Robinson D, Cao Q, Prensner JR, Yocum AK, Wang R, Fries DF, Han B, Asangani IA, Cao X, Li Y, Omenn GS, Pflueger D, Gopalan A, Reuter VE, Kahoud ER, Cantley LC, Rubin MA, Palanisamy N, Varambally S, Chinnaiyan AM
published in: Cancer discovery
information resource reference: Characterization of KRAS rearrangements in metastatic prostate cancer. Cancer Discov. 2011 Jun; 1(1):35-43.
journal title abbreviation: Cancer Discov
publication date: 2011-06-01T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

p85a SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation.
PubMed Identifier: 22342344
author list: Comb WC, Hutti JE, Cogswell P, Cantley LC, Baldwin AS
published in: Molecular cell
information resource reference: p85a SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation. Mol Cell. 2012 Mar 30; 45(6):719-30.
journal title abbreviation: Mol Cell
publication date: 2012-02-16T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization.
PubMed Identifier: 21436401
author list: Amato S, Liu X, Zheng B, Cantley L, Rakic P, Man HY
published in: Science (New York, N.Y.)
information resource reference: AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization. Science. 2011 Apr 08; 332(6026):247-51.
journal title abbreviation: Science
publication date: 2011-03-24T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

I?B kinase a phosphorylation of TRAF4 downregulates innate immune signaling.
PubMed Identifier: 22547678
author list: Marinis JM, Hutti JE, Homer CR, Cobb BA, Cantley LC, McDonald C, Abbott DW
published in: Molecular and cellular biology
information resource reference: I?B kinase a phosphorylation of TRAF4 downregulates innate immune signaling. Mol Cell Biol. 2012 Jul; 32(13):2479-89.
journal title abbreviation: Mol Cell Biol
publication date: 2012-04-30T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Introduction.
PubMed Identifier: 20582535
author list: Yuan TL, Cantley LC
published in: Current topics in microbiology and immunology
information resource reference: Introduction. Curr Top Microbiol Immunol. 2010; 346:1-7.
journal title abbreviation: Curr Top Microbiol Immunol
publication date: 2010-01-01T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 340465
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: ATM and lymphoid malignancies; use of oriented peptide libraries to identify novel substrates of ATM critical in downstream signaling pathways.

Authorship 691654
type: Authorship
author rank in publication: 20
linked author: Cantley, Lewis
linked information resource: Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.

Authorship 692974
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation.

Authorship 692826
type: Authorship
author rank in publication: 9
linked author: Cantley, Lewis
linked information resource: Lin28 enhances tissue repair by reprogramming cellular metabolism.

Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation.
PubMed Identifier: 24095280
author list: Shen CH, Yuan P, Perez-Lorenzo R, Zhang Y, Lee SX, Ou Y, Asara JM, Cantley LC, Zheng B
published in: Molecular cell
information resource reference: Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation. Mol Cell. 2013 Oct 24; 52(2):161-72.
journal title abbreviation: Mol Cell
publication date: 2013-10-03T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.
PubMed Identifier: 24209622
author list: Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC
published in: Cell
information resource reference: Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell. 2013 Nov 07; 155(4):844-57.
journal title abbreviation: Cell
publication date: 2013-11-07T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Lin28 enhances tissue repair by reprogramming cellular metabolism.
PubMed Identifier: 24209617
author list: Shyh-Chang N, Zhu H, Yvanka de Soysa T, Shinoda G, Seligson MT, Tsanov KM, Nguyen L, Asara JM, Cantley LC, Daley GQ
published in: Cell
information resource reference: Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell. 2013 Nov 07; 155(4):778-92.
journal title abbreviation: Cell
publication date: 2013-11-07T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 359472
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/1160211

Authorship 175584
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Blockade of ATP binding site of P2 purinoceptors in rat parotid acinar cells by isothiocyanate compounds.

Authorship 697661
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway.

What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway.
PubMed Identifier: 24265156
author list: Klempner SJ, Myers AP, Cantley LC
published in: Cancer discovery
information resource reference: What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway. Cancer Discov. 2013 Dec; 3(12):1345-54.
journal title abbreviation: Cancer Discov
publication date: 2013-11-21T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

James Stillman Professor of Developmental Biology
is primary position: true
position in department: Genetics
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: James Stillman Professor of Developmental Biology
position in organization: Harvard Medical School

Authorship 20837
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate.

Authorship 231696
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Altered metabolism in cancer.

Authorship 236506
type: Authorship
author rank in publication: 10
linked author: Cantley, Lewis
linked information resource: Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2.

Authorship 277264
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Recognition and specificity in protein tyrosine kinase-mediated signalling.

Authorship 171868
type: Authorship
author rank in publication: 10
linked author: Cantley, Lewis
linked information resource: The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.

Authorship 263525
type: Authorship
author rank in publication: 9
linked author: Cantley, Lewis
linked information resource: The erbB3 gene product is a receptor for heregulin.

Authorship 274402
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: Ouabain-resistant transfectants of the murine ouabain resistance gene contain mutations in the alpha-subunit of the Na,K-ATPase.

Assistant Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Oncology
sort order: 1
type: Position
HR job title: Assistant Professor of Medicine
position in organization: Dana-Farber Cancer Institute

Authorship 416551
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Inositol 1,4,5-trisphosphate stimulates phosphorylation of a 62,000-dalton protein in monkey fibroblast and bovine brain cell lysates.

Authorship 418279
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries.

Authorship 433970
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Characterization of PXK as a protein involved in epidermal growth factor receptor trafficking.

Authorship 45566
type: Authorship
author rank in publication: 10
linked author: Cantley, Lewis
linked information resource: Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations.

Authorship 285693
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Signal transduction. Grabbing phosphoproteins.

Authorship 290628
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2.

Authorship 30159
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Phosphoinositide kinases.

Authorship 324576
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.

Authorship 327813
type: Authorship
author rank in publication: 18
linked author: Cantley, Lewis
linked information resource: MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.

Authorship 331149
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: The role of the ErbB family members in non-small cell lung cancers sensitive to epidermal growth factor receptor kinase inhibitors.

Authorship 253636
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.

Authorship 96974
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.

Authorship 341763
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain.

Authorship 356109
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence.

Authorship 175714
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Targeting the PI3K-Akt pathway in human cancer: rationale and promise.

Authorship 36273
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Phosphoinositide 3-kinase and the regulation of cell growth.

Authorship 364072
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.

Authorship 187170
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Differential regulation of the phosphoinositide 3-kinase and MAP kinase pathways by hepatocyte growth factor vs. insulin-like growth factor-I in myogenic cells.

Authorship 264330
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Fate of a bioactive fluorescent wortmannin derivative in cells.

Authorship 202052
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: The inositol 5'-phosphatase SHIP binds to immunoreceptor signaling motifs and responds to high affinity IgE receptor aggregation.

Authorship 208521
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity.

Authorship 340922
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation.

Authorship 372353
type: Authorship
author rank in publication: 15
linked author: Cantley, Lewis
linked information resource: Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.

Authorship 375412
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Interferon regulatory factor-3 is an in vivo target of DNA-PK.

Authorship 426930
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: Oncogenes and signal transduction.

Authorship 321910
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Identification and characterization of a phosphoinositide phosphate kinase homolog.

Barry R. and Irene T. Bloom Professorship of Public Health
is primary position: true
position in department: Molecular Metabolism
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Barry R. and Irene T. Bloom Professorship of Public Health
position in organization: Harvard T.H. Chan School of Public Health

Authorship 314715
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity.

Authorship 389773
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells.

Authorship 395583
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Expression of an ouabain resistance gene in transfected cells. Ouabain treatment induces a K+-transport system.

Authorship 405090
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts.

Authorship 483701
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions.

Authorship 505615
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Expression of c-ret promotes morphogenesis and cell survival in mIMCD-3 cells.

Authorship 419051
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis.

Authorship 458556
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.

Authorship 88489
type: Authorship
author rank in publication: 9
linked author: Cantley, Lewis
linked information resource: The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.

Authorship 485389
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells.

Authorship 420659
type: Authorship
author rank in publication: 10
linked author: Cantley, Lewis
linked information resource: Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

Authorship 251418
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: AKT/PKB signaling: navigating downstream.

Authorship 251950
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Elevation of [Ca2+]i and the activation of ion channels and fluxes by extracellular ATP and phospholipase C-linked agonists in rat parotid acinar cells.

Authorship 376298
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.

Authorship 486574
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: Location of binding sites on the (Na,K)-ATPase for fluorescein-5'-isothiocyanate and ouabain.

Authorship 495083
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation.

Authorship 445515
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: A flattened face for membranes.

Authorship 482343
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells.

Authorship 497168
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Signal transduction and membrane traffic: the PITP/phosphoinositide connection.

Authorship 505262
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: A rapid method for determining protein kinase phosphorylation specificity.

Authorship 494861
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Pyruvate kinase M2 is a phosphotyrosine-binding protein.

Authorship 512564
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Altered signaling and cell cycle regulation in embryonal stem cells with a disruption of the gene for phosphoinositide 3-kinase regulatory subunit p85alpha.

Authorship 567480
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling.

Authorship 28636
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Delta endotoxin is a potent inhibitor of the (Na,K)-ATPase.

Authorship 288799
type: Authorship
author rank in publication: 10
linked author: Cantley, Lewis
linked information resource: PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer.

Authorship 299529
type: Authorship
author rank in publication: 9
linked author: Cantley, Lewis
linked information resource: ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines.

Authorship 59084
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling.

Authorship 312143
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells.

Authorship 315064
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange.

Authorship 316045
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms.

Authorship 325130
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase.

Authorship 510377
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes.

Authorship 512357
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Amiloride inhibits murine erythroleukemia cell differentiation: evidence for a Ca2+ requirement for commitment.

Authorship 542368
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells.

Authorship 54267
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry.

Authorship 545618
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase.

Authorship 553473
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: A study of the vanadate-trapped state of the (Na,K)-ATPase. Evidence against interacting nucleotide site models.

Authorship 577068
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: SH2 domains recognize specific phosphopeptide sequences.

Authorship 9610
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: Identification of small molecule inhibitors of pyruvate kinase M2.

Authorship 63025
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Growth factor and oncogene influences on cell growth regulation.

Authorship 39765
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.

Authorship 419176
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Specificity of LIM domain interactions with receptor tyrosine kinases.

Authorship 330074
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: A slow interconversion between active and inactive states of the (Na-K)ATPase.

Authorship 331347
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Evidence that inhibitors of anion exchange induce a transmembrane conformational change in band 3.

Authorship 337454
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.

Authorship 20220
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Clathrin-coated vesicles contain an ATP-dependent proton pump.

Authorship 158703
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice.

Authorship 449827
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: Transcription. Translocating tubby.

Authorship 162235
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Wortmannin-C20 conjugates generate wortmannin.

Authorship 303427
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Rho family GTPases bind to phosphoinositide kinases.

Authorship 456664
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain.

Authorship 476020
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Akt/protein kinase B promotes organ growth in transgenic mice.

Authorship 476196
type: Authorship
author rank in publication: 9
linked author: Cantley, Lewis
linked information resource: Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation.

Authorship 487908
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: Signal transduction by the hepatocyte growth factor receptor, c-met. Activation of the phosphatidylinositol 3-kinase.

Authorship 499620
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Mechanism of anion exchange across the red cell membrane by band 3: interactions between stilbenedisulfonate and NAP-taurine binding sites.

Authorship 504889
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.

Authorship 515144
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Hitting the target: emerging technologies in the search for kinase substrates.

Authorship 485858
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: Phosphatidylinositol kinases and cell transformation.

Authorship 535588
type: Authorship
author rank in publication: 9
linked author: Cantley, Lewis
linked information resource: Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.

Authorship 529768
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/861755

Authorship 559861
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Molecular phylogenetics of mastodon and Tyrannosaurus rex.

Authorship 571125
type: Authorship
author rank in publication: 19
linked author: Cantley, Lewis
linked information resource: The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor.

Authorship 499065
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.

Authorship 401925
type: Authorship
author rank in publication: 9
linked author: Cantley, Lewis
linked information resource: T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling.

Authorship 185888
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Rapid release of bound glucose-6-phosphate dehydrogenase by growth factors. Correlation with increased enzymatic activity.

Authorship 7280
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Lipid research picks up speed on the slopes of Taos.

Authorship 189631
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Phosphoinositide kinase activity and transformation.

Authorship 181852
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO.

Authorship 96693
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: Activation of beef heart mitochondrial adenosine triphosphatase by 2,4-dinitrophenol.

Authorship 2558
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C.

Authorship 291031
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Activation of phosphatidylinositol 3-kinase by insulin.

Authorship 474812
type: Authorship
author rank in publication: 20
linked author: Cantley, Lewis
linked information resource: Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.

Authorship 520561
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38.

Authorship 549272
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene.

Authorship 559151
type: Authorship
author rank in publication: 15
linked author: Cantley, Lewis
linked information resource: Bidirectional transport of amino acids regulates mTOR and autophagy.

Authorship 80170
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.

Authorship 230608
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding.

Authorship 237276
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeleton.

Authorship 286281
type: Authorship
author rank in publication: 12
linked author: Cantley, Lewis
linked information resource: Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.

Authorship 193596
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Understanding the Warburg effect: the metabolic requirements of cell proliferation.

Authorship 34057
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation.

Authorship 340849
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: CV-1 cell recipients of the mouse ouabain resistance gene express a ouabain-insensitive Na,K-ATPase after growth in cardioactive steroids.

Authorship 184193
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: PtdIns(4,5)P2 functions at the cleavage furrow during cytokinesis.

Authorship 202283
type: Authorship
author rank in publication: 18
linked author: Cantley, Lewis
linked information resource: Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.

Authorship 256020
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Production of novel polyphosphoinositides in vivo is linked to cell transformation by polyomavirus middle T antigen.

Authorship 259957
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength.

Authorship 368269
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Bovine brain contains two types of phosphatidylinositol kinase.

Authorship 397659
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains.

Authorship 39809
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins.

Authorship 262764
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.

Authorship 271710
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: The (Na,K)-ATPase of Friend erythroleukemia cells is phosphorylated near the ATP hydrolysis by an endogenous membrane-bound kinase.

Authorship 301259
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Ion fluxes and differentiation in transformed cell lines.

Authorship 30303
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation.

Authorship 43145
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Peptide libraries: at the crossroads of proteomics and bioinformatics.

Authorship 291583
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Characterization of a Ca2+-stimulated Mg2+-dependent adenosine triphosphatase in Friend murine erythroleukemia cell plasma membranes.

Authorship 330994
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Heregulin stimulates mitogenesis and phosphatidylinositol 3-kinase in mouse fibroblasts transfected with erbB2/neu and erbB3.

Authorship 368992
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: An integrated vector system for cellular studies of phage display-derived peptides.

Authorship 512322
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: The plasma membrane (Mg2+)-dependent adenosine triphosphatase from the human erythrocyte is not an ion pump.

Authorship 258648
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: Oncogenes and phosphatidylinositol turnover.

Authorship 232965
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: A murine genomic DNA fragment amplifies ouabain-induced Na,K-ATPase alpha/beta-subunit mRNA up-regulation and confers ouabain resistance.

Authorship 211090
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.

Authorship 542200
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression.

Authorship 566692
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase.

Authorship 92054
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Increasing the intracellular Na+ concentration induces differentiation in a pre-B lymphocyte cell line.

Authorship 251536
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: A characterization of vanadate interactions with the (Na,K)-ATPase. Mechanistic and regulatory implications.

Authorship 252027
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation.

Authorship 279266
type: Authorship
author rank in publication: 10
linked author: Cantley, Lewis
linked information resource: Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha.

Authorship 314910
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: A wortmannin-cetuximab as a double drug.

Authorship 318387
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals.

Authorship 352221
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C.

Authorship 402146
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Regulation of the Lck SH2 domain by tyrosine phosphorylation.

Authorship 402767
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Extracellular ATP elevates intracellular free calcium in rat parotid acinar cells.

Authorship 239448
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: SH2 domain specificity and activity modified by a single residue.

Authorship 220529
type: Authorship
author rank in publication: 11
linked author: Cantley, Lewis
linked information resource: Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism.

Authorship 274121
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: The PX domains of p47phox and p40phox bind to lipid products of PI(3)K.

Authorship 247332
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Determination of protease cleavage site motifs using mixture-based oriented peptide libraries.

Authorship 297256
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro.

Authorship 369287
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Phosphorylation by LAMMER protein kinases: determination of a consensus site, identification of in vitro substrates, and implications for substrate preferences.

Authorship 286907
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity.

Authorship 377895
type: Authorship
author rank in publication: 10
linked author: Cantley, Lewis
linked information resource: A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast.

Authorship 382883
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Regulation of c-Src tyrosine kinase activity by the Src SH2 domain.

Authorship 434384
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author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs.

Authorship 487926
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.

Authorship 53421
type: Authorship
author rank in publication: 10
linked author: Cantley, Lewis
linked information resource: The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.

Authorship 543393
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author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Apoptosis. A Bad kinase makes good.

Authorship 549388
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author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling.

Authorship 155370
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: Characterization of sulfhydryl groups on chloroplast coupling factor 1 exposed by heat activation.

Authorship 456220
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Effects of extracellular ATP on ion transport systems and [Ca2+]i in rat parotid acinar cells. Comparison with the muscarinic agonist carbachol.

Authorship 249348
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation.

Authorship 290475
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: PI3K: downstream AKTion blocks apoptosis.

Authorship 406663
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen.

Authorship 282585
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Ras, PI(3)K and mTOR signalling controls tumour cell growth.

Authorship 409305
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA-ligand interaction.

Authorship 333311
type: Authorship
author rank in publication: 15
linked author: Cantley, Lewis
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/805239

Authorship 35010
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

Authorship 381135
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals.

Authorship 398041
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate.

Authorship 440834
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Isolation of a potent (Na-K)ATPase inhibitor from striated muscle.

Authorship 470283
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase.

Authorship 4786
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Differential signaling by the epidermal growth factor-like growth factors neuregulin-1 and neuregulin-2.

Authorship 52072
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.

Authorship 555188
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: The C2 domain of PKCdelta is a phosphotyrosine binding domain.

Authorship 71171
type: Authorship
author rank in publication: 10
linked author: Cantley, Lewis
linked information resource: Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.

Authorship 71425
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: 1,25(OH)2D3 increases calcium and phosphatidylinositol metabolism in differentiating cultured human keratinocytes.

Authorship 281342
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Determination of the specific substrate sequence motifs of protein kinase C isozymes.

Authorship 297877
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Subcellular locations of phosphatidylinositol 4-kinase isoforms.

Authorship 321827
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells.

Authorship 172389
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif.

Authorship 347211
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Vanadium stimulates the (Na+,K+) pump in friend erythroleukemia cells and blocks erythropoiesis.

Authorship 259019
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice.

Authorship 302417
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase.

Authorship 304041
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Phosphatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae.

Authorship 322289
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply.

Authorship 334484
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Phosphatidylinositol 4-kinases. Assays and product analysis.

Authorship 337753
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: The active site structure of Na+- and K+-stimulated ATPase. Location of a specific fluorescein isothiocyanate reactive site.

Authorship 343935
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Getting knit-PI3Ky: PIK3CA mutation status to direct multimodality therapy?

Authorship 357985
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors.

Authorship 366651
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis.

Authorship 385999
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Phosphatidylinositol-3 kinase and growth regulation.

Authorship 390979
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.

Authorship 406767
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity.

Authorship 431076
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Delta endotoxin inhibits Rb+ uptake, lowers cytoplasmic pH and inhibits a K+-ATPase in Manduca sexta CHE cells.

Authorship 488984
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.

Authorship 5109
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: The role of lipid-derived second messengers in cell growth and transformation.

Authorship 417126
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha.

Authorship 400192
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: A monoclonal antibody distinguishes two types of phosphatidylinositol 4-kinase.

Authorship 537667
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Extracellular ATP increases free cytosolic calcium in rat parotid acinar cells. Differences from phospholipase C-linked receptor agonists.

Authorship 54408
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors.

Authorship 177160
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Glutathione reduces cytoplasmic vanadate. Mechanism and physiological implications.

Authorship 305022
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Hypothalamic sodium-transport inhibitor is a high-affinity reversible inhibitor of Na+-K+-ATPase.

Authorship 347970
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Slow self-activation enhances the potency of viridin prodrugs.

Authorship 404902
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Catalytic specificity of protein-tyrosine kinases is critical for selective signalling.

Authorship 420690
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase.

Authorship 440417
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase.

Authorship 463722
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase.

Authorship 464784
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Calcium regulates the commitment of murine erythroleukemia cells to terminal erythroid differentiation.

Authorship 531219
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase.

Authorship 85514
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: A motif-based profile scanning approach for genome-wide prediction of signaling pathways.

Authorship 384206
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms.

Authorship 386685
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Using peptide libraries to identify optimal cleavage motifs for proteolytic enzymes.

Authorship 418860
type: Authorship
author rank in publication: 13
linked author: Cantley, Lewis
linked information resource: Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.

Authorship 527234
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Location of the stilbenedisulfonate binding site of the human erythrocyte anion-exchange system by resonance energy transfer.

Authorship 438384
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Mitogens and ion fluxes.

Authorship 497151
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.

Authorship 535021
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Characterization of the ATP-dependent proton pump of clathrin-coated vesicles.

Authorship 536248
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

Authorship 7201
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Synthesis and activity of C11-modified wortmannin probes for PI3 kinase.

Authorship 29835
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Characterization and purification of membrane-associated phosphatidylinositol-4-phosphate kinase from human red blood cells.

Authorship 304136
type: Authorship
author rank in publication: 12
linked author: Cantley, Lewis
linked information resource: Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.

Authorship 371981
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase.

Authorship 433201
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: The phosphoinositide 3-kinase pathway.

Authorship 472616
type: Authorship
author rank in publication: 11
linked author: Cantley, Lewis
linked information resource: Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy.

Authorship 506845
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: A single point mutation switches the specificity of group III Src homology (SH) 2 domains to that of group I SH2 domains.

Authorship 574052
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation.

Authorship 72571
type: Authorship
author rank in publication: 11
linked author: Cantley, Lewis
linked information resource: Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis.

Authorship 563789
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: Investigation of quercetin binding sites on chloroplast coupling factor 1.

Assistant Professor
sort order: 2
type: Faculty Rank

Associate Professor
sort order: 1
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Instructor
sort order: 4
type: Faculty Rank

Authorship 77688
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: Lewis C. Cantley.

Authorship 85248
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Role of mitochondrial membrane potential in the regulation of murine erythroleukemia cell differentiation.

Authorship 90272
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Membrane biochemistry of the ouabain-resistant potassium transport system.

Authorship 56519
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate.

Authorship 524084
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity.

Authorship 554115
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.

Authorship 576147
type: Authorship
author rank in publication: 17
linked author: Cantley, Lewis
linked information resource: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.

Authorship 188304
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: The role of phosphoinositide 3-kinase lipid products in cell function.

Authorship 501673
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Phosphorylation of the (Na,K)-ATPase by a plasma membrane-bound protein kinase in friend erythroleukemia cells.

Authorship 55868
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins.

Authorship 562967
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia.

The Role of PTEN and the PI3K Pathway in Prostate Cancer
end date: 2013-05-31
principal investigator name: CANTLEY, LEWIS C
start date: 2001-05-01
type: Grant
sponsor award id: P01CA089021

SCOR IN MOLECULAR MEDICINE AND ATHEROSCLEROSIS
end date: 2002-03-31
principal investigator name: CANTLEY, LEWIS C
start date: 1997-04-23
type: Grant
sponsor award id: P50HL056993

Authorship 78828
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Phosphatidylinositol 3-kinase.

Authorship 67418
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: The role of phosphoinositide 3-kinase in human disease.

Authorship 99240
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Kinetic analysis of guanosine 5'-O-(3-thiotriphosphate) effects on phosphatidylinositol turnover in NRK cell homogenates.

Authorship 359471
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: The fate of cytoplasmic vanadium. Implications on (NA,K)-ATPase inhibition.

Authorship 363389
type: Authorship
author rank in publication: 6
linked author: Cantley, Lewis
linked information resource: Identification of efficient pentapeptide substrates for the tyrosine kinase pp60c-src.

Authorship 370011
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Biochemistry. PI3K charges ahead.

Authorship 398877
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Phosphoinositide kinases.

Authorship 40310
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: Reaction of (Na-K)ATPase with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole: evidence for an essential tyrosine at the active site.

Authorship 459373
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: Cell regulation.

Authorship 488889
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: ZIP codes for delivering SH2 domains.

Authorship 497883
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: Vanadate inhibits the red cell (Na+, K+) ATPase from the cytoplasmic side.

Authorship 506541
type: Authorship
author rank in publication: 13
linked author: Cantley, Lewis
linked information resource: Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase.

Authorship 517789
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Lipid second messengers.

Authorship 524435
type: Authorship
author rank in publication: 17
linked author: Cantley, Lewis
linked information resource: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.

Authorship 551358
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn.

Authorship 6720
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Protein kinase C of human erythrocytes phosphorylates bands 4.1 and 4.9.

Authorship 68744
type: Authorship
author rank in publication: 3
linked author: Cantley, Lewis
linked information resource: Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx.

Authorship 72170
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Structural aspects of the red cell anion exchange protein.

Authorship 329460
type: Authorship
author rank in publication: 7
linked author: Cantley, Lewis
linked information resource: In-gel stable isotope labeling for relative quantification using mass spectrometry.

Authorship 333087
type: Authorship
author rank in publication: 10
linked author: Cantley, Lewis
linked information resource: Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo.

Authorship 340453
type: Authorship
author rank in publication: 20
linked author: Cantley, Lewis
linked information resource: Overview of the Alliance for Cellular Signaling.

Authorship 391361
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products.

Authorship 399534
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate.

Authorship 41547
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit.

Authorship 427560
type: Authorship
author rank in publication: 4
linked author: Cantley, Lewis
linked information resource: The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase.

Authorship 50670
type: Authorship
author rank in publication: 1
linked author: Cantley, Lewis
linked information resource: Characterization of nucleotide binding sites on chloroplast coupling factor 1.

Authorship 516977
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Stimulation of the T3-T cell receptor-associated Ca2+ influx enhances the activity of the Na+/H+ exchanger in a leukemic human T cell line.

Authorship 54885
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants.

Authorship 554879
type: Authorship
author rank in publication: 10
linked author: Cantley, Lewis
linked information resource: Recognition of unique carboxyl-terminal motifs by distinct PDZ domains.

Authorship 56358
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates.

Authorship 65815
type: Authorship
author rank in publication: 5
linked author: Cantley, Lewis
linked information resource: Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation.

Authorship 76820
type: Authorship
author rank in publication: 8
linked author: Cantley, Lewis
linked information resource: Sequence specificity of C-terminal Src kinase (CSK)--a comparison with Src-related kinases c-Fgr and Lyn.

450 Brookline Ave
type: Address
address line 1: Dana-Farber Cancer Institute
address line 3: 450 Brookline Ave
city: Boston
postal code: 02215
state or province: MA

Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity.
PubMed Identifier: 8816504
author list: Klinghoffer RA, Duckworth B, Valius M, Cantley L, Kazlauskas A
published in: Molecular and cellular biology
information resource reference: Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity. Mol Cell Biol. 1996 Oct; 16(10):5905-14.
journal title abbreviation: Mol Cell Biol
publication date: 1996-10-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphoinositide 3-kinase and the regulation of cell growth.
PubMed Identifier: 8764841
author list: Carpenter CL, Cantley LC
published in: Biochimica et biophysica acta
information resource reference: Phosphoinositide 3-kinase and the regulation of cell growth. Biochim Biophys Acta. 1996 Aug 08; 1288(1):M11-6.
journal title abbreviation: Biochim Biophys Acta
publication date: 1996-08-08T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Regulation of the Lck SH2 domain by tyrosine phosphorylation.
PubMed Identifier: 8798764
author list: Couture C, Songyang Z, Jascur T, Williams S, Tailor P, Cantley LC, Mustelin T
published in: The Journal of biological chemistry
information resource reference: Regulation of the Lck SH2 domain by tyrosine phosphorylation. J Biol Chem. 1996 Oct 04; 271(40):24880-4.
journal title abbreviation: J Biol Chem
publication date: 1996-10-04T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphoinositide kinases.
PubMed Identifier: 8791418
author list: Carpenter CL, Cantley LC
published in: Current opinion in cell biology
information resource reference: Phosphoinositide kinases. Curr Opin Cell Biol. 1996 Apr; 8(2):153-8.
journal title abbreviation: Curr Opin Cell Biol
publication date: 1996-04-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.
PubMed Identifier: 8798481
author list: Milani D, Mazzoni M, Borgatti P, Zauli G, Cantley L, Capitani S
published in: The Journal of biological chemistry
information resource reference: Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells. J Biol Chem. 1996 Sep 20; 271(38):22961-4.
journal title abbreviation: J Biol Chem
publication date: 1996-09-20T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit.
PubMed Identifier: 8962058
author list: Musacchio A, Cantley LC, Harrison SC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14373-8.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1996-12-10T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2.
PubMed Identifier: 8980225
author list: Vikkula M, Boon LM, Carraway KL, Calvert JT, Diamonti AJ, Goumnerov B, Pasyk KA, Marchuk DA, Warman ML, Cantley LC, Mulliken JB, Olsen BR
published in: Cell
information resource reference: Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. Cell. 1996 Dec 27; 87(7):1181-90.
journal title abbreviation: Cell
publication date: 1996-12-27T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate.
PubMed Identifier: 9005852
author list: Franke TF, Kaplan DR, Cantley LC, Toker A
published in: Science (New York, N.Y.)
information resource reference: Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science. 1997 Jan 31; 275(5300):665-8.
journal title abbreviation: Science
publication date: 1997-01-31T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase.
PubMed Identifier: 9020160
author list: Meyers R, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase. J Biol Chem. 1997 Feb 14; 272(7):4384-90.
journal title abbreviation: J Biol Chem
publication date: 1997-02-14T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

PI3K: downstream AKTion blocks apoptosis.
PubMed Identifier: 9038334
author list: Franke TF, Kaplan DR, Cantley LC
published in: Cell
information resource reference: PI3K: downstream AKTion blocks apoptosis. Cell. 1997 Feb 21; 88(4):435-7.
journal title abbreviation: Cell
publication date: 1997-02-21T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.
PubMed Identifier: 9367159
author list: Rameh LE, Tolias KF, Duckworth BC, Cantley LC
published in: Nature
information resource reference: A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate. Nature. 1997 Nov 13; 390(6656):192-6.
journal title abbreviation: Nature
publication date: 1997-11-13T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin.
PubMed Identifier: 1656240
author list: Kapeller R, Chen KS, Yoakim M, Schaffhausen BS, Backer J, White MF, Cantley LC, Ruderman NB
published in: Molecular endocrinology (Baltimore, Md.)
information resource reference: Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin. Mol Endocrinol. 1991 Jun; 5(6):769-77.
journal title abbreviation: Mol Endocrinol
publication date: 1991-06-01T00:00:00
year: 1991
type: Academic Article
type: Article
type: Document
type: Information Resource

A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast.
PubMed Identifier: 15249580
author list: Mitra P, Zhang Y, Rameh LE, Ivshina MP, McCollum D, Nunnari JJ, Hendricks GM, Kerr ML, Field SJ, Cantley LC, Ross AH
published in: The Journal of cell biology
information resource reference: A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. J Cell Biol. 2004 Jul 19; 166(2):205-11.
journal title abbreviation: J Cell Biol
publication date: 2004-07-12T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations.
PubMed Identifier: 16106023
author list: Mukohara T, Engelman JA, Hanna NH, Yeap BY, Kobayashi S, Lindeman N, Halmos B, Pearlberg J, Tsuchihashi Z, Cantley LC, Tenen DG, Johnson BE, Jänne PA
published in: Journal of the National Cancer Institute
information resource reference: Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations. J Natl Cancer Inst. 2005 Aug 17; 97(16):1185-94.
journal title abbreviation: J Natl Cancer Inst
publication date: 2005-08-17T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis.
PubMed Identifier: 16434494
author list: Schulze H, Korpal M, Hurov J, Kim SW, Zhang J, Cantley LC, Graf T, Shivdasani RA
published in: Blood
information resource reference: Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. Blood. 2006 May 15; 107(10):3868-75.
journal title abbreviation: Blood
publication date: 2006-01-24T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors.
PubMed Identifier: 9096338
author list: Klingmüller U, Wu H, Hsiao JG, Toker A, Duckworth BC, Cantley LC, Lodish HF
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc Natl Acad Sci U S A. 1997 Apr 01; 94(7):3016-21.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1997-04-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
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Interleukin 3-dependent survival by the Akt protein kinase.
PubMed Identifier: 9326612
author list: Songyang Z, Baltimore D, Cantley LC, Kaplan DR, Franke TF
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Interleukin 3-dependent survival by the Akt protein kinase. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11345-50.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1997-10-14T00:00:00
year: 1997
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type: Article
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The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.
PubMed Identifier: 9407100
author list: Lupher ML, Songyang Z, Shoelson SE, Cantley LC, Band H
published in: The Journal of biological chemistry
information resource reference: The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70. J Biol Chem. 1997 Dec 26; 272(52):33140-4.
journal title abbreviation: J Biol Chem
publication date: 1997-12-26T00:00:00
year: 1997
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SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells.
PubMed Identifier: 9472028
author list: Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD
published in: The Journal of cell biology
information resource reference: SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. J Cell Biol. 1998 Feb 23; 140(4):737-50.
journal title abbreviation: J Cell Biol
publication date: 1998-02-23T00:00:00
year: 1998
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type: Information Resource

The conserved phosphoinositide 3-kinase pathway determines heart size in mice.
PubMed Identifier: 10835352
author list: Shioi T, Kang PM, Douglas PS, Hampe J, Yballe CM, Lawitts J, Cantley LC, Izumo S
published in: The EMBO journal
information resource reference: The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J. 2000 Jun 01; 19(11):2537-48.
journal title abbreviation: EMBO J
publication date: 2000-06-01T00:00:00
year: 2000
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Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi.
PubMed Identifier: 14512424
author list: Martins LM, Turk BE, Cowling V, Borg A, Jarrell ET, Cantley LC, Downward J
published in: The Journal of biological chemistry
information resource reference: Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi. J Biol Chem. 2003 Dec 05; 278(49):49417-27.
journal title abbreviation: J Biol Chem
publication date: 2003-09-25T00:00:00
year: 2003
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The LKB1 tumor suppressor negatively regulates mTOR signaling.
PubMed Identifier: 15261145
author list: Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC
published in: Cancer cell
information resource reference: The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell. 2004 Jul; 6(1):91-9.
journal title abbreviation: Cancer Cell
publication date: 2004-07-01T00:00:00
year: 2004
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Recognition of unique carboxyl-terminal motifs by distinct PDZ domains.
PubMed Identifier: 8974395
author list: Songyang Z, Fanning AS, Fu C, Xu J, Marfatia SM, Chishti AH, Crompton A, Chan AC, Anderson JM, Cantley LC
published in: Science (New York, N.Y.)
information resource reference: Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science. 1997 Jan 03; 275(5296):73-7.
journal title abbreviation: Science
publication date: 1997-01-03T00:00:00
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The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence.
PubMed Identifier: 9148966
author list: Grabs D, Slepnev VI, Songyang Z, David C, Lynch M, Cantley LC, De Camilli P
published in: The Journal of biological chemistry
information resource reference: The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J Biol Chem. 1997 May 16; 272(20):13419-25.
journal title abbreviation: J Biol Chem
publication date: 1997-05-16T00:00:00
year: 1997
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Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism.
PubMed Identifier: 9395400
author list: Yaffe MB, Schutkowski M, Shen M, Zhou XZ, Stukenberg PT, Rahfeld JU, Xu J, Kuang J, Kirschner MW, Fischer G, Cantley LC, Lu KP
published in: Science (New York, N.Y.)
information resource reference: Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science. 1997 Dec 12; 278(5345):1957-60.
journal title abbreviation: Science
publication date: 1997-12-12T00:00:00
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Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals.
PubMed Identifier: 9524119
author list: Scharenberg AM, El-Hillal O, Fruman DA, Beitz LO, Li Z, Lin S, Gout I, Cantley LC, Rawlings DJ, Kinet JP
published in: The EMBO journal
information resource reference: Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals. EMBO J. 1998 Apr 01; 17(7):1961-72.
journal title abbreviation: EMBO J
publication date: 1998-04-01T00:00:00
year: 1998
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Phosphoinositide kinases.
PubMed Identifier: 9759495
author list: Fruman DA, Meyers RE, Cantley LC
published in: Annual review of biochemistry
information resource reference: Phosphoinositide kinases. Annu Rev Biochem. 1998; 67:481-507.
journal title abbreviation: Annu Rev Biochem
publication date: 1998-01-01T00:00:00
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Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.
PubMed Identifier: 10945990
author list: Obata T, Yaffe MB, Leparc GG, Piro ET, Maegawa H, Kashiwagi A, Kikkawa R, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J Biol Chem. 2000 Nov 17; 275(46):36108-15.
journal title abbreviation: J Biol Chem
publication date: 2000-11-17T00:00:00
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D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate.
PubMed Identifier: 8955143
author list: Hartwig JH, Kung S, Kovacsovics T, Janmey PA, Cantley LC, Stossel TP, Toker A
published in: The Journal of biological chemistry
information resource reference: D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate. J Biol Chem. 1996 Dec 20; 271(51):32986-93.
journal title abbreviation: J Biol Chem
publication date: 1996-12-20T00:00:00
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The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C.
PubMed Identifier: 9045671
author list: Derman MP, Toker A, Hartwig JH, Spokes K, Falck JR, Chen CS, Cantley LC, Cantley LG
published in: The Journal of biological chemistry
information resource reference: The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C. J Biol Chem. 1997 Mar 07; 272(10):6465-70.
journal title abbreviation: J Biol Chem
publication date: 1997-03-07T00:00:00
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Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle.
PubMed Identifier: 144127
author list: Cantley LC, Josephson L, Warner R, Yanagisawa M, Lechene C, Guidotti G
published in: The Journal of biological chemistry
information resource reference: Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle. J Biol Chem. 1977 Nov 10; 252(21):7421-3.
journal title abbreviation: J Biol Chem
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A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase.
PubMed Identifier: 11090635
author list: Nishikawa K, Sawasdikosol S, Fruman DA, Lai J, Songyang Z, Burakoff SJ, Yaffe MB, Cantley LC
published in: Molecular cell
information resource reference: A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase. Mol Cell. 2000 Oct; 6(4):969-74.
journal title abbreviation: Mol Cell
publication date: 2000-10-01T00:00:00
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Bidirectional transport of amino acids regulates mTOR and autophagy.
PubMed Identifier: 19203585
author list: Nicklin P, Bergman P, Zhang B, Triantafellow E, Wang H, Nyfeler B, Yang H, Hild M, Kung C, Wilson C, Myer VE, MacKeigan JP, Porter JA, Wang YK, Cantley LC, Finan PM, Murphy LO
published in: Cell
information resource reference: Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 2009 Feb 06; 136(3):521-34.
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publication date: 2009-02-06T00:00:00
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The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase.
PubMed Identifier: 2556641
author list: Varticovski L, Druker B, Morrison D, Cantley L, Roberts T
published in: Nature
information resource reference: The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase. Nature. 1989 Dec 07; 342(6250):699-702.
journal title abbreviation: Nature
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The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.
PubMed Identifier: 20133837
author list: Clower CV, Chatterjee D, Wang Z, Cantley LC, Vander Heiden MG, Krainer AR
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proc Natl Acad Sci U S A. 2010 Feb 02; 107(5):1894-9.
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Phosphatidylinositol 3-kinase confers resistance to encephalomyocarditis and herpes simplex virus-induced cell death through the activation of distinct downstream effectors.
PubMed Identifier: 11591783
author list: Prejean C, Sarma T, Kurnasov O, Usacheva A, Hemmings B, Cantley L, Fruman DA, Morrison LA, Buller RM, Colamonici OR
published in: Journal of immunology (Baltimore, Md. : 1950)
information resource reference: Phosphatidylinositol 3-kinase confers resistance to encephalomyocarditis and herpes simplex virus-induced cell death through the activation of distinct downstream effectors. J Immunol. 2001 Oct 15; 167(8):4553-9.
journal title abbreviation: J Immunol
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Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.
PubMed Identifier: 11784871
author list: Ueki K, Fruman DA, Brachmann SM, Tseng YH, Cantley LC, Kahn CR
published in: Molecular and cellular biology
information resource reference: Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Mol Cell Biol. 2002 Feb; 22(3):965-77.
journal title abbreviation: Mol Cell Biol
publication date: 2002-02-01T00:00:00
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Differential regulation of the phosphoinositide 3-kinase and MAP kinase pathways by hepatocyte growth factor vs. insulin-like growth factor-I in myogenic cells.
PubMed Identifier: 15194438
author list: Halevy O, Cantley LC
published in: Experimental cell research
information resource reference: Differential regulation of the phosphoinositide 3-kinase and MAP kinase pathways by hepatocyte growth factor vs. insulin-like growth factor-I in myogenic cells. Exp Cell Res. 2004 Jul 01; 297(1):224-34.
journal title abbreviation: Exp Cell Res
publication date: 2004-07-01T00:00:00
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Ouabain-resistant transfectants of the murine ouabain resistance gene contain mutations in the alpha-subunit of the Na,K-ATPase.
PubMed Identifier: 1324928
author list: Cantley LG, Zhou XM, Cunha MJ, Epstein J, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Ouabain-resistant transfectants of the murine ouabain resistance gene contain mutations in the alpha-subunit of the Na,K-ATPase. J Biol Chem. 1992 Aug 25; 267(24):17271-8.
journal title abbreviation: J Biol Chem
publication date: 1992-08-25T00:00:00
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Signalling through the lipid products of phosphoinositide-3-OH kinase.
PubMed Identifier: 9192891
author list: Toker A, Cantley LC
published in: Nature
information resource reference: Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature. 1997 Jun 12; 387(6634):673-6.
journal title abbreviation: Nature
publication date: 1997-06-12T00:00:00
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Sequence specificity of C-terminal Src kinase (CSK)--a comparison with Src-related kinases c-Fgr and Lyn.
PubMed Identifier: 9208935
author list: Ruzzene M, Songyang Z, Marin O, Donella-Deana A, Brunati AM, Guerra B, Agostinis P, Cantley LC, Pinna LA
published in: European journal of biochemistry
information resource reference: Sequence specificity of C-terminal Src kinase (CSK)--a comparison with Src-related kinases c-Fgr and Lyn. Eur J Biochem. 1997 Jun 01; 246(2):433-9.
journal title abbreviation: Eur J Biochem
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Phosphatidylinositol-3 kinase and growth regulation.
PubMed Identifier: 1339706
author list: Soltoff SP, Carpenter CL, Auger KR, Kapeller R, Schaffhausen B, Cantley LC
published in: Cold Spring Harbor symposia on quantitative biology
information resource reference: Phosphatidylinositol-3 kinase and growth regulation. Cold Spring Harb Symp Quant Biol. 1992; 57:75-80.
journal title abbreviation: Cold Spring Harb Symp Quant Biol
publication date: 1992-01-01T00:00:00
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Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade.
PubMed Identifier: 10636929
author list: Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ
published in: The Journal of biological chemistry
information resource reference: Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade. J Biol Chem. 2000 Jan 21; 275(3):2219-30.
journal title abbreviation: J Biol Chem
publication date: 2000-01-21T00:00:00
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The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation.
PubMed Identifier: 12897244
author list: Carricaburu V, Lamia KA, Lo E, Favereaux L, Payrastre B, Cantley LC, Rameh LE
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9867-72.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2003-08-01T00:00:00
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Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes.
PubMed Identifier: 9171339
author list: Rapoport I, Miyazaki M, Boll W, Duckworth B, Cantley LC, Shoelson S, Kirchhausen T
published in: The EMBO journal
information resource reference: Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes. EMBO J. 1997 May 01; 16(9):2240-50.
journal title abbreviation: EMBO J
publication date: 1997-05-01T00:00:00
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Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells.
PubMed Identifier: 9233798
author list: Holland SJ, Gale NW, Gish GD, Roth RA, Songyang Z, Cantley LC, Henkemeyer M, Yancopoulos GD, Pawson T
published in: The EMBO journal
information resource reference: Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells. EMBO J. 1997 Jul 01; 16(13):3877-88.
journal title abbreviation: EMBO J
publication date: 1997-07-01T00:00:00
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Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase.
PubMed Identifier: 1380963
author list: Soltoff SP, Rabin SL, Cantley LC, Kaplan DR
published in: The Journal of biological chemistry
information resource reference: Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase. J Biol Chem. 1992 Aug 25; 267(24):17472-7.
journal title abbreviation: J Biol Chem
publication date: 1992-08-25T00:00:00
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Effects of extracellular ATP on ion transport systems and [Ca2+]i in rat parotid acinar cells. Comparison with the muscarinic agonist carbachol.
PubMed Identifier: 1689766
author list: Soltoff SP, McMillian MK, Cragoe EJ, Cantley LC, Talamo BR
published in: The Journal of general physiology
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journal title abbreviation: J Gen Physiol
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The SH2 domain-containing inositol 5'-phosphatase (SHIP) recruits the p85 subunit of phosphoinositide 3-kinase during FcgammaRIIb1-mediated inhibition of B cell receptor signaling.
PubMed Identifier: 10066815
author list: Gupta N, Scharenberg AM, Fruman DA, Cantley LC, Kinet JP, Long EO
published in: The Journal of biological chemistry
information resource reference: The SH2 domain-containing inositol 5'-phosphatase (SHIP) recruits the p85 subunit of phosphoinositide 3-kinase during FcgammaRIIb1-mediated inhibition of B cell receptor signaling. J Biol Chem. 1999 Mar 12; 274(11):7489-94.
journal title abbreviation: J Biol Chem
publication date: 1999-03-12T00:00:00
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Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.
PubMed Identifier: 10801797
author list: O'Neill T, Dwyer AJ, Ziv Y, Chan DW, Lees-Miller SP, Abraham RH, Lai JH, Hill D, Shiloh Y, Cantley LC, Rathbun GA
published in: The Journal of biological chemistry
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journal title abbreviation: J Biol Chem
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Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation.
PubMed Identifier: 15928075
author list: Park J, Hu Y, Murthy TV, Vannberg F, Shen B, Rolfs A, Hutti JE, Cantley LC, Labaer J, Harlow E, Brizuela L
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation. Proc Natl Acad Sci U S A. 2005 Jun 07; 102(23):8114-9.
journal title abbreviation: Proc Natl Acad Sci U S A
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Akt/protein kinase B promotes organ growth in transgenic mice.
PubMed Identifier: 11909972
author list: Shioi T, McMullen JR, Kang PM, Douglas PS, Obata T, Franke TF, Cantley LC, Izumo S
published in: Molecular and cellular biology
information resource reference: Akt/protein kinase B promotes organ growth in transgenic mice. Mol Cell Biol. 2002 Apr; 22(8):2799-809.
journal title abbreviation: Mol Cell Biol
publication date: 2002-04-01T00:00:00
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Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
PubMed Identifier: 10549287
author list: Poy F, Yaffe MB, Sayos J, Saxena K, Morra M, Sumegi J, Cantley LC, Terhorst C, Eck MJ
published in: Molecular cell
information resource reference: Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. Mol Cell. 1999 Oct; 4(4):555-61.
journal title abbreviation: Mol Cell
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Ligand discrimination in signaling through an ErbB4 receptor homodimer.
PubMed Identifier: 10867024
author list: Sweeney C, Lai C, Riese DJ, Diamonti AJ, Cantley LC, Carraway KL
published in: The Journal of biological chemistry
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Expression of an ouabain-resistant Na,K-ATPase in CV-1 cells after transfection with a cDNA encoding the rat Na,K-ATPase alpha 1 subunit.
PubMed Identifier: 2836394
author list: Emanuel JR, Schulz J, Zhou XM, Kent RB, Housman D, Cantley L, Levenson R
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Elevation of [Ca2+]i and the activation of ion channels and fluxes by extracellular ATP and phospholipase C-linked agonists in rat parotid acinar cells.
PubMed Identifier: 1705402
author list: Soltoff SP, McMillian MK, Lechleiter JD, Cantley LC, Talamo BR
published in: Annals of the New York Academy of Sciences
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Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo.
PubMed Identifier: 17372192
author list: Hurov JB, Huang M, White LS, Lennerz J, Choi CS, Cho YR, Kim HJ, Prior JL, Piwnica-Worms D, Cantley LC, Kim JK, Shulman GI, Piwnica-Worms H
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5680-5.
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Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes.
PubMed Identifier: 8918456
author list: Boll W, Ohno H, Songyang Z, Rapoport I, Cantley LC, Bonifacino JS, Kirchhausen T
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journal title abbreviation: EMBO J
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Determination of the specific substrate sequence motifs of protein kinase C isozymes.
PubMed Identifier: 8995387
author list: Nishikawa K, Toker A, Johannes FJ, Songyang Z, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Determination of the specific substrate sequence motifs of protein kinase C isozymes. J Biol Chem. 1997 Jan 10; 272(2):952-60.
journal title abbreviation: J Biol Chem
publication date: 1997-01-10T00:00:00
year: 1997
type: Academic Article
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Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes.
PubMed Identifier: 1318025
author list: Graziani A, Ling LE, Endemann G, Carpenter CL, Cantley LC
published in: The Biochemical journal
information resource reference: Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes. Biochem J. 1992 May 15; 284 ( Pt 1):39-45.
journal title abbreviation: Biochem J
publication date: 1992-05-15T00:00:00
year: 1992
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Growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors.
PubMed Identifier: 11297548
author list: Sweeney C, Fambrough D, Huard C, Diamonti AJ, Lander ES, Cantley LC, Carraway KL
published in: The Journal of biological chemistry
information resource reference: Growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors. J Biol Chem. 2001 Jun 22; 276(25):22685-98.
journal title abbreviation: J Biol Chem
publication date: 2001-04-10T00:00:00
year: 2001
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type: Information Resource

The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor.
PubMed Identifier: 12859901
author list: Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD, Yuan J
published in: Cell
information resource reference: The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell. 2003 Jul 11; 114(1):99-111.
journal title abbreviation: Cell
publication date: 2003-07-11T00:00:00
year: 2003
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type: Document
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1,25(OH)2D3 increases calcium and phosphatidylinositol metabolism in differentiating cultured human keratinocytes.
PubMed Identifier: 15539189
author list: MacLaughlin JA, Cantley LC, Holick MF
published in: The Journal of nutritional biochemistry
information resource reference: 1,25(OH)2D3 increases calcium and phosphatidylinositol metabolism in differentiating cultured human keratinocytes. J Nutr Biochem. 1990 Feb; 1(2):81-7.
journal title abbreviation: J Nutr Biochem
publication date: 1990-02-01T00:00:00
year: 1990
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PtdIns(4,5)P2 functions at the cleavage furrow during cytokinesis.
PubMed Identifier: 16085494
author list: Field SJ, Madson N, Kerr ML, Galbraith KA, Kennedy CE, Tahiliani M, Wilkins A, Cantley LC
published in: Current biology : CB
information resource reference: PtdIns(4,5)P2 functions at the cleavage furrow during cytokinesis. Curr Biol. 2005 Aug 09; 15(15):1407-12.
journal title abbreviation: Curr Biol
publication date: 2005-08-09T00:00:00
year: 2005
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Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy.
PubMed Identifier: 16227599
author list: Luo J, McMullen JR, Sobkiw CL, Zhang L, Dorfman AL, Sherwood MC, Logsdon MN, Horner JW, DePinho RA, Izumo S, Cantley LC
published in: Molecular and cellular biology
information resource reference: Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy. Mol Cell Biol. 2005 Nov; 25(21):9491-502.
journal title abbreviation: Mol Cell Biol
publication date: 2005-11-01T00:00:00
year: 2005
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type: Information Resource

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.
PubMed Identifier: 16308421
author list: Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC
published in: Science (New York, N.Y.)
information resource reference: The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science. 2005 Dec 09; 310(5754):1642-6.
journal title abbreviation: Science
publication date: 2005-11-24T00:00:00
year: 2005
type: Academic Article
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type: Document
type: Information Resource

https://connects.catalyst.harvard.edu/Profiles/profile/805239
PubMed Identifier: 8887677
author list: Songyang Z, Lu KP, Kwon YT, Tsai LH, Filhol O, Cochet C, Brickey DA, Soderling TR, Bartleson C, Graves DJ, DeMaggio AJ, Hoekstra MF, Blenis J, Hunter T, Cantley LC
published in: Molecular and cellular biology
information resource reference: A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol Cell Biol. 1996 Nov; 16(11):6486-93.
journal title abbreviation: Mol Cell Biol
publication date: 1996-11-01T00:00:00
year: 1996
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type: Information Resource
label: A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1.

Subcellular locations of phosphatidylinositol 4-kinase isoforms.
PubMed Identifier: 9148941
author list: Wong K, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Subcellular locations of phosphatidylinositol 4-kinase isoforms. J Biol Chem. 1997 May 16; 272(20):13236-41.
journal title abbreviation: J Biol Chem
publication date: 1997-05-16T00:00:00
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Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins.
PubMed Identifier: 9484780
author list: Welsh M, Songyang Z, Frantz JD, Trüb T, Reedquist KA, Karlsson T, Miyazaki M, Cantley LC, Band H, Shoelson SE
published in: Oncogene
information resource reference: Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. Oncogene. 1998 Feb 19; 16(7):891-901.
journal title abbreviation: Oncogene
publication date: 1998-02-19T00:00:00
year: 1998
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Association of protein kinase Cmu with type II phosphatidylinositol 4-kinase and type I phosphatidylinositol-4-phosphate 5-kinase.
PubMed Identifier: 9722541
author list: Nishikawa K, Toker A, Wong K, Marignani PA, Johannes FJ, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Association of protein kinase Cmu with type II phosphatidylinositol 4-kinase and type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 1998 Sep 04; 273(36):23126-33.
journal title abbreviation: J Biol Chem
publication date: 1998-09-04T00:00:00
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Expression of c-ret promotes morphogenesis and cell survival in mIMCD-3 cells.
PubMed Identifier: 10198418
author list: O'Rourke DA, Sakurai H, Spokes K, Kjelsberg C, Takahashi M, Nigam S, Cantley L
published in: The American journal of physiology
information resource reference: Expression of c-ret promotes morphogenesis and cell survival in mIMCD-3 cells. Am J Physiol. 1999 04; 276(4):F581-8.
journal title abbreviation: Am J Physiol
publication date: 1999-04-01T00:00:00
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Pathways for phosphoinositide synthesis.
PubMed Identifier: 10358929
author list: Tolias KF, Cantley LC
published in: Chemistry and physics of lipids
information resource reference: Pathways for phosphoinositide synthesis. Chem Phys Lipids. 1999 Apr; 98(1-2):69-77.
journal title abbreviation: Chem Phys Lipids
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Novel polyphosphoinositides in cell growth and activation.
PubMed Identifier: 1654970
author list: Auger KR, Cantley LC
published in: Cancer cells (Cold Spring Harbor, N.Y. : 1989)
information resource reference: Novel polyphosphoinositides in cell growth and activation. Cancer Cells. 1991 Jul; 3(7):263-70.
journal title abbreviation: Cancer Cells
publication date: 1991-07-01T00:00:00
year: 1991
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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.
PubMed Identifier: 12150915
author list: Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC
published in: Molecular cell
information resource reference: Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell. 2002 Jul; 10(1):151-62.
journal title abbreviation: Mol Cell
publication date: 2002-07-01T00:00:00
year: 2002
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An integrated vector system for cellular studies of phage display-derived peptides.
PubMed Identifier: 12419351
author list: Voss SD, DeGrand AM, Romeo GR, Cantley LC, Frangioni JV
published in: Analytical biochemistry
information resource reference: An integrated vector system for cellular studies of phage display-derived peptides. Anal Biochem. 2002 Sep 15; 308(2):364-72.
journal title abbreviation: Anal Biochem
publication date: 2002-09-15T00:00:00
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Activation of phosphatidylinositol 3-kinase by insulin.
PubMed Identifier: 2154747
author list: Ruderman NB, Kapeller R, White MF, Cantley LC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Activation of phosphatidylinositol 3-kinase by insulin. Proc Natl Acad Sci U S A. 1990 Feb; 87(4):1411-5.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1990-02-01T00:00:00
year: 1990
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Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells.
PubMed Identifier: 9394803
author list: Borgatti P, Zauli G, Colamussi ML, Gibellini D, Previati M, Cantley LL, Capitani S
published in: European journal of immunology
information resource reference: Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells. Eur J Immunol. 1997 Nov; 27(11):2805-11.
journal title abbreviation: Eur J Immunol
publication date: 1997-11-01T00:00:00
year: 1997
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The structural basis for 14-3-3:phosphopeptide binding specificity.
PubMed Identifier: 9428519
author list: Yaffe MB, Rittinger K, Volinia S, Caron PR, Aitken A, Leffers H, Gamblin SJ, Smerdon SJ, Cantley LC
published in: Cell
information resource reference: The structural basis for 14-3-3:phosphopeptide binding specificity. Cell. 1997 Dec 26; 91(7):961-71.
journal title abbreviation: Cell
publication date: 1997-12-26T00:00:00
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Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate.
PubMed Identifier: 9442017
author list: Klarlund JK, Rameh LE, Cantley LC, Buxton JM, Holik JJ, Sakelis C, Patki V, Corvera S, Czech MP
published in: The Journal of biological chemistry
information resource reference: Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem. 1998 Jan 23; 273(4):1859-62.
journal title abbreviation: J Biol Chem
publication date: 1998-01-23T00:00:00
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Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation.
PubMed Identifier: 9774973
author list: Parker D, Jhala US, Radhakrishnan I, Yaffe MB, Reyes C, Shulman AI, Cantley LC, Wright PE, Montminy M
published in: Molecular cell
information resource reference: Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. Mol Cell. 1998 Sep; 2(3):353-9.
journal title abbreviation: Mol Cell
publication date: 1998-09-01T00:00:00
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Phosphatidylinositol 4-kinases. Assays and product analysis.
PubMed Identifier: 10427554
author list: Meyers RE, Cantley LC
published in: Methods in molecular biology (Clifton, N.J.)
information resource reference: Phosphatidylinositol 4-kinases. Assays and product analysis. Methods Mol Biol. 1998; 105:99-108.
journal title abbreviation: Methods Mol Biol
publication date: 1998-01-01T00:00:00
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Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply.
PubMed Identifier: 20513425
author list: Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon SO, Cantley LC, Blenis J
published in: Molecular cell
information resource reference: Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Mol Cell. 2010 May 28; 38(4):487-99.
journal title abbreviation: Mol Cell
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Altered metabolism in cancer.
PubMed Identifier: 20598111
author list: Locasale JW, Cantley LC
published in: BMC biology
information resource reference: Altered metabolism in cancer. BMC Biol. 2010 Jun 25; 8:88.
journal title abbreviation: BMC Biol
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year: 2010
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Transcription. Translocating tubby.
PubMed Identifier: 11408644
author list: Cantley LC
published in: Science (New York, N.Y.)
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journal title abbreviation: Science
publication date: 2001-06-15T00:00:00
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In vivo near-infrared fluorescence imaging of osteoblastic activity.
PubMed Identifier: 11731784
author list: Zaheer A, Lenkinski RE, Mahmood A, Jones AG, Cantley LC, Frangioni JV
published in: Nature biotechnology
information resource reference: In vivo near-infrared fluorescence imaging of osteoblastic activity. Nat Biotechnol. 2001 Dec; 19(12):1148-54.
journal title abbreviation: Nat Biotechnol
publication date: 2001-12-01T00:00:00
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Phosphatidylinositol kinases and cell transformation.
PubMed Identifier: 2827283
author list: Cantley L, Whitman M, Kaplan DR, Chahwala SB, Fleischman L, Endemann G, Schaffhausen BS, Roberts TM
published in: Symposium on Fundamental Cancer Research
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publication date: 1986-01-01T00:00:00
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Extracellular ATP increases free cytosolic calcium in rat parotid acinar cells. Differences from phospholipase C-linked receptor agonists.
PubMed Identifier: 2848507
author list: McMillian MK, Soltoff SP, Lechleiter JD, Cantley LC, Talamo BR
published in: The Biochemical journal
information resource reference: Extracellular ATP increases free cytosolic calcium in rat parotid acinar cells. Differences from phospholipase C-linked receptor agonists. Biochem J. 1988 Oct 01; 255(1):291-300.
journal title abbreviation: Biochem J
publication date: 1988-10-01T00:00:00
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Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase.
PubMed Identifier: 9188528
author list: Chang HW, Aoki M, Fruman D, Auger KR, Bellacosa A, Tsichlis PN, Cantley LC, Roberts TM, Vogt PK
published in: Science (New York, N.Y.)
information resource reference: Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. Science. 1997 Jun 20; 276(5320):1848-50.
journal title abbreviation: Science
publication date: 1997-06-20T00:00:00
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The fate of cytoplasmic vanadium. Implications on (NA,K)-ATPase inhibition.
PubMed Identifier: 217870
author list: Cantley LC, Aisen P
published in: The Journal of biological chemistry
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journal title abbreviation: J Biol Chem
publication date: 1979-03-25T00:00:00
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Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms.
PubMed Identifier: 16199078
author list: Gozani O, Field SJ, Ferguson CG, Ewalt M, Mahlke C, Cantley LC, Prestwich GD, Yuan J
published in: Advances in enzyme regulation
information resource reference: Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms. Adv Enzyme Regul. 2005; 45:171-85.
journal title abbreviation: Adv Enzyme Regul
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Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C.
PubMed Identifier: 9446569
author list: Soltoff SP, Avraham H, Avraham S, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C. J Biol Chem. 1998 Jan 30; 273(5):2653-60.
journal title abbreviation: J Biol Chem
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Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling.
PubMed Identifier: 9726983
author list: Rameh LE, Rhee SG, Spokes K, Kazlauskas A, Cantley LC, Cantley LG
published in: The Journal of biological chemistry
information resource reference: Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling. J Biol Chem. 1998 Sep 11; 273(37):23750-7.
journal title abbreviation: J Biol Chem
publication date: 1998-09-11T00:00:00
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Differential signaling by the epidermal growth factor-like growth factors neuregulin-1 and neuregulin-2.
PubMed Identifier: 9756944
author list: Crovello CS, Lai C, Cantley LC, Carraway KL
published in: The Journal of biological chemistry
information resource reference: Differential signaling by the epidermal growth factor-like growth factors neuregulin-1 and neuregulin-2. J Biol Chem. 1998 Oct 09; 273(41):26954-61.
journal title abbreviation: J Biol Chem
publication date: 1998-10-09T00:00:00
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Covalent reactions of wortmannin under physiological conditions.
PubMed Identifier: 17379147
author list: Yuan H, Barnes KR, Weissleder R, Cantley L, Josephson L
published in: Chemistry & biology
information resource reference: Covalent reactions of wortmannin under physiological conditions. Chem Biol. 2007 Mar; 14(3):321-8.
journal title abbreviation: Chem Biol
publication date: 2007-03-01T00:00:00
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ZIP codes for delivering SH2 domains.
PubMed Identifier: 15055580
author list: Songyang Z, Cantley LC
published in: Cell
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journal title abbreviation: Cell
publication date: 2004-01-23T00:00:00
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The role of phosphoinositide 3-kinase in human disease.
PubMed Identifier: 16970176
author list: Cantley LC
published in: Harvey lectures
information resource reference: The role of phosphoinositide 3-kinase in human disease. Harvey Lect. 2004-2005; 100:103-22.
journal title abbreviation: Harvey Lect
publication date: 2004-01-01T00:00:00
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Purification and characterization of phosphoinositide 3-kinase from rat liver.
PubMed Identifier: 2174051
author list: Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS, Cantley LC
published in: The Journal of biological chemistry
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journal title abbreviation: J Biol Chem
publication date: 1990-11-15T00:00:00
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AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo.
PubMed Identifier: 17438183
author list: Perry B, Banyard J, McLaughlin ER, Watnick R, Sohn A, Brindley DN, Obata T, Cantley LC, Cohen C, Arbiser JL
published in: Archives of dermatology
information resource reference: AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo. Arch Dermatol. 2007 Apr; 143(4):504-6.
journal title abbreviation: Arch Dermatol
publication date: 2007-04-01T00:00:00
year: 2007
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Interpreting sequences from mastodon and T. rex.
PubMed Identifier: 17823333
author list: Asara JM, Garavelli JS, Slatter DA, Schweitzer MH, Freimark LM, Phillips M, Cantley LC
published in: Science (New York, N.Y.)
information resource reference: Interpreting sequences from mastodon and T. rex. Science. 2007 Sep 07; 317(5843):1324-5.
journal title abbreviation: Science
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Specificity in protein-tyrosine kinase signaling.
PubMed Identifier: 9344240
author list: Cantley LC, Songyang Z
published in: Advances in second messenger and phosphoprotein research
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journal title abbreviation: Adv Second Messenger Phosphoprotein Res
publication date: 1997-01-01T00:00:00
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Characterization of a Rac1- and RhoGDI-associated lipid kinase signaling complex.
PubMed Identifier: 9447972
author list: Tolias KF, Couvillon AD, Cantley LC, Carpenter CL
published in: Molecular and cellular biology
information resource reference: Characterization of a Rac1- and RhoGDI-associated lipid kinase signaling complex. Mol Cell Biol. 1998 Feb; 18(2):762-70.
journal title abbreviation: Mol Cell Biol
publication date: 1998-02-01T00:00:00
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Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products.
PubMed Identifier: 10681597
author list: Lu-Kuo JM, Fruman DA, Joyal DM, Cantley LC, Katz HR
published in: The Journal of biological chemistry
information resource reference: Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products. J Biol Chem. 2000 Feb 25; 275(8):6022-9.
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Overview of the Alliance for Cellular Signaling.
PubMed Identifier: 12478301
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A wortmannin-cetuximab as a double drug.
PubMed Identifier: 19883074
author list: Smith RA, Yuan H, Weissleder R, Cantley LC, Josephson L
published in: Bioconjugate chemistry
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journal title abbreviation: Bioconjug Chem
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The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase.
PubMed Identifier: 1718989
author list: Graziani A, Gramaglia D, Cantley LC, Comoglio PM
published in: The Journal of biological chemistry
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journal title abbreviation: J Biol Chem
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Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.
PubMed Identifier: 22541435
author list: Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, DePinho RA
published in: Cell
information resource reference: Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell. 2012 Apr 27; 149(3):656-70.
journal title abbreviation: Cell
publication date: 2012-04-27T00:00:00
year: 2012
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Characterization and purification of membrane-associated phosphatidylinositol-4-phosphate kinase from human red blood cells.
PubMed Identifier: 2538472
author list: Ling LE, Schulz JT, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Characterization and purification of membrane-associated phosphatidylinositol-4-phosphate kinase from human red blood cells. J Biol Chem. 1989 Mar 25; 264(9):5080-8.
journal title abbreviation: J Biol Chem
publication date: 1989-03-25T00:00:00
year: 1989
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Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.
PubMed Identifier: 21659605
author list: Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villén J, Kubica N, Hoffman GR, Cantley LC, Gygi SP, Blenis J
published in: Science (New York, N.Y.)
information resource reference: Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science. 2011 Jun 10; 332(6035):1322-6.
journal title abbreviation: Science
publication date: 2011-06-10T00:00:00
year: 2011
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https://connects.catalyst.harvard.edu/Profiles/profile/845974
PubMed Identifier: 21688263
author list: Hanai J, Doro N, Sasaki AT, Kobayashi S, Cantley LC, Seth P, Sukhatme VP
published in: Journal of cellular physiology
information resource reference: Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways. J Cell Physiol. 2012 Apr; 227(4):1709-20.
journal title abbreviation: J Cell Physiol
publication date: 2012-04-01T00:00:00
year: 2012
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label: Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways.

Targeting the PI3K-Akt pathway in human cancer: rationale and promise.
PubMed Identifier: 14585353
author list: Luo J, Manning BD, Cantley LC
published in: Cancer cell
information resource reference: Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell. 2003 Oct; 4(4):257-62.
journal title abbreviation: Cancer Cell
publication date: 2003-10-01T00:00:00
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The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
PubMed Identifier: 14718924
author list: Turk BE, Wong TY, Schwarzenbacher R, Jarrell ET, Leppla SH, Collier RJ, Liddington RC, Cantley LC
published in: Nature structural & molecular biology
information resource reference: The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nat Struct Mol Biol. 2004 Jan; 11(1):60-6.
journal title abbreviation: Nat Struct Mol Biol
publication date: 2003-12-29T00:00:00
year: 2003
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Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement.
PubMed Identifier: 15767666
author list: Brachmann SM, Yballe CM, Innocenti M, Deane JA, Fruman DA, Thomas SM, Cantley LC
published in: Molecular and cellular biology
information resource reference: Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement. Mol Cell Biol. 2005 Apr; 25(7):2593-606.
journal title abbreviation: Mol Cell Biol
publication date: 2005-04-01T00:00:00
year: 2005
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Extracellular ATP induces ion fluxes and inhibits growth of Friend erythroleukemia cells.
PubMed Identifier: 6594338
author list: Chahwala SB, Cantley LC
published in: The Journal of biological chemistry
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journal title abbreviation: J Biol Chem
publication date: 1984-11-25T00:00:00
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A single point mutation switches the specificity of group III Src homology (SH) 2 domains to that of group I SH2 domains.
PubMed Identifier: 7592796
author list: Songyang Z, Gish G, Mbamalu G, Pawson T, Cantley LC
published in: The Journal of biological chemistry
information resource reference: A single point mutation switches the specificity of group III Src homology (SH) 2 domains to that of group I SH2 domains. J Biol Chem. 1995 Nov 03; 270(44):26029-32.
journal title abbreviation: J Biol Chem
publication date: 1995-11-03T00:00:00
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Vanadate inhibits the red cell (Na+, K+) ATPase from the cytoplasmic side.
PubMed Identifier: 211419
author list: Cantley LC, Resh MD, Guidotti G
published in: Nature
information resource reference: Vanadate inhibits the red cell (Na+, K+) ATPase from the cytoplasmic side. Nature. 1978 Apr 06; 272(5653):552-4.
journal title abbreviation: Nature
publication date: 1978-04-06T00:00:00
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Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes.
PubMed Identifier: 15987685
author list: Keilhack H, David FS, McGregor M, Cantley LC, Neel BG
published in: The Journal of biological chemistry
information resource reference: Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes. J Biol Chem. 2005 Sep 02; 280(35):30984-93.
journal title abbreviation: J Biol Chem
publication date: 2005-06-29T00:00:00
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In-Gel Stable-Isotope Labeling (ISIL): a strategy for mass spectrometry-based relative quantification.
PubMed Identifier: 16396506
author list: Asara JM, Zhang X, Zheng B, Christofk HH, Wu N, Cantley LC
published in: Journal of proteome research
information resource reference: In-Gel Stable-Isotope Labeling (ISIL): a strategy for mass spectrometry-based relative quantification. J Proteome Res. 2006 Jan; 5(1):155-63.
journal title abbreviation: J Proteome Res
publication date: 2006-01-01T00:00:00
year: 2006
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MMP-20 is predominately a tooth-specific enzyme with a deep catalytic pocket that hydrolyzes type V collagen.
PubMed Identifier: 16548514
author list: Turk BE, Lee DH, Yamakoshi Y, Klingenhoff A, Reichenberger E, Wright JT, Simmer JP, Komisarof JA, Cantley LC, Bartlett JD
published in: Biochemistry
information resource reference: MMP-20 is predominately a tooth-specific enzyme with a deep catalytic pocket that hydrolyzes type V collagen. Biochemistry. 2006 Mar 28; 45(12):3863-74.
journal title abbreviation: Biochemistry
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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.
PubMed Identifier: 18725988
author list: Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, Egia A, Sasaki AT, Thomas G, Kozma SC, Papa A, Nardella C, Cantley LC, Baselga J, Pandolfi PP
published in: The Journal of clinical investigation
information resource reference: Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest. 2008 Sep; 118(9):3065-74.
journal title abbreviation: J Clin Invest
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year: 2008
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Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C.
PubMed Identifier: 2457390
author list: Varticovski L, Chahwala SB, Whitman M, Cantley L, Schindler D, Chow EP, Sinclair LK, Pepinsky RB
published in: Biochemistry
information resource reference: Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C. Biochemistry. 1988 May 17; 27(10):3682-90.
journal title abbreviation: Biochemistry
publication date: 1988-05-17T00:00:00
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T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38.
PubMed Identifier: 7544353
author list: Fukazawa T, Reedquist KA, Panchamoorthy G, Soltoff S, Trub T, Druker B, Cantley L, Shoelson SE, Band H
published in: The Journal of biological chemistry
information resource reference: T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38. J Biol Chem. 1995 Aug 25; 270(34):20177-82.
journal title abbreviation: J Biol Chem
publication date: 1995-08-25T00:00:00
year: 1995
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type: Information Resource

Phosphatidylinositol 4,5-bisphosphate synthesis is required for activation of phospholipase D in U937 cells.
PubMed Identifier: 7890622
author list: Pertile P, Liscovitch M, Chalifa V, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Phosphatidylinositol 4,5-bisphosphate synthesis is required for activation of phospholipase D in U937 cells. J Biol Chem. 1995 Mar 10; 270(10):5130-5.
journal title abbreviation: J Biol Chem
publication date: 1995-03-10T00:00:00
year: 1995
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type: Information Resource

Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.
PubMed Identifier: 16880400
author list: Taniguchi CM, Tran TT, Kondo T, Luo J, Ueki K, Cantley LC, Kahn CR
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN. Proc Natl Acad Sci U S A. 2006 Aug 08; 103(32):12093-7.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2006-07-31T00:00:00
year: 2006
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type: Document
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Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene.
PubMed Identifier: 8921377
author list: Fruman DA, Cantley LC, Carpenter CL
published in: Genomics
information resource reference: Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene. Genomics. 1996 Oct 01; 37(1):113-21.
journal title abbreviation: Genomics
publication date: 1996-10-01T00:00:00
year: 1996
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A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains.
PubMed Identifier: 9268346
author list: Rameh LE, Arvidsson Ak, Carraway KL, Couvillon AD, Rathbun G, Crompton A, VanRenterghem B, Czech MP, Ravichandran KS, Burakoff SJ, Wang DS, Chen CS, Cantley LC
published in: The Journal of biological chemistry
information resource reference: A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains. J Biol Chem. 1997 Aug 29; 272(35):22059-66.
journal title abbreviation: J Biol Chem
publication date: 1997-08-29T00:00:00
year: 1997
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type: Information Resource

https://connects.catalyst.harvard.edu/Profiles/profile/861755
PubMed Identifier: 1371171
author list: Ling LE, Druker BJ, Cantley LC, Roberts TM
published in: Journal of virology
information resource reference: Transformation-defective mutants of polyomavirus middle T antigen associate with phosphatidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells. J Virol. 1992 Mar; 66(3):1702-8.
journal title abbreviation: J Virol
publication date: 1992-03-01T00:00:00
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label: Transformation-defective mutants of polyomavirus middle T antigen associate with phosphatidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells.

The use of peptide library for the determination of kinase peptide substrates.
PubMed Identifier: 9523263
author list: Songyang Z, Cantley LC
published in: Methods in molecular biology (Clifton, N.J.)
information resource reference: The use of peptide library for the determination of kinase peptide substrates. Methods Mol Biol. 1998; 87:87-98.
journal title abbreviation: Methods Mol Biol
publication date: 1998-01-01T00:00:00
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The role of phosphoinositide 3-kinase lipid products in cell function.
PubMed Identifier: 10085060
author list: Rameh LE, Cantley LC
published in: The Journal of biological chemistry
information resource reference: The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem. 1999 Mar 26; 274(13):8347-50.
journal title abbreviation: J Biol Chem
publication date: 1999-03-26T00:00:00
year: 1999
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A novel pathway for the formation of phosphatidylinositol 3,4-bisphosphate. Phosphorylation of phosphatidylinositol 3-monophosphate by phosphatidylinositol-3-monophosphate 4-kinase.
PubMed Identifier: 2176203
author list: Yamamoto K, Graziani A, Carpenter C, Cantley LC, Lapetina EG
published in: The Journal of biological chemistry
information resource reference: A novel pathway for the formation of phosphatidylinositol 3,4-bisphosphate. Phosphorylation of phosphatidylinositol 3-monophosphate by phosphatidylinositol-3-monophosphate 4-kinase. J Biol Chem. 1990 Dec 25; 265(36):22086-9.
journal title abbreviation: J Biol Chem
publication date: 1990-12-25T00:00:00
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Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity.
PubMed Identifier: 2441878
author list: Kaplan DR, Whitman M, Schaffhausen B, Pallas DC, White M, Cantley L, Roberts TM
published in: Cell
information resource reference: Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity. Cell. 1987 Sep 25; 50(7):1021-9.
journal title abbreviation: Cell
publication date: 1987-09-25T00:00:00
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Phosphatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae.
PubMed Identifier: 2555343
author list: Auger KR, Carpenter CL, Cantley LC, Varticovski L
published in: The Journal of biological chemistry
information resource reference: Phosphatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae. J Biol Chem. 1989 Dec 05; 264(34):20181-4.
journal title abbreviation: J Biol Chem
publication date: 1989-12-05T00:00:00
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Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.
PubMed Identifier: 20017496
author list: Boxer MB, Jiang JK, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ
published in: Journal of medicinal chemistry
information resource reference: Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem. 2010 Feb 11; 53(3):1048-55.
journal title abbreviation: J Med Chem
publication date: 2010-02-11T00:00:00
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Delta endotoxin is a potent inhibitor of the (Na,K)-ATPase.
PubMed Identifier: 3003059
author list: English LH, Cantley LC
published in: The Journal of biological chemistry
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journal title abbreviation: J Biol Chem
publication date: 1986-01-25T00:00:00
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Phosphoinositide kinase activity and transformation.
PubMed Identifier: 3019785
author list: Whitman M, Kaplan D, Cantley L, Roberts TM, Schaffhausen B
published in: Federation proceedings
information resource reference: Phosphoinositide kinase activity and transformation. Fed Proc. 1986 Oct; 45(11):2647-52.
journal title abbreviation: Fed Proc
publication date: 1986-10-01T00:00:00
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AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.
PubMed Identifier: 23453806
author list: Wu N, Zheng B, Shaywitz A, Dagon Y, Tower C, Bellinger G, Shen CH, Wen J, Asara J, McGraw TE, Kahn BB, Cantley LC
published in: Molecular cell
information resource reference: AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. Mol Cell. 2013 Mar 28; 49(6):1167-75.
journal title abbreviation: Mol Cell
publication date: 2013-02-28T00:00:00
year: 2013
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Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.
PubMed Identifier: 20451379
author list: Jiang JK, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ
published in: Bioorganic & medicinal chemistry letters
information resource reference: Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg Med Chem Lett. 2010 Jun 01; 20(11):3387-93.
journal title abbreviation: Bioorg Med Chem Lett
publication date: 2010-04-11T00:00:00
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PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.
PubMed Identifier: 20696900
author list: Poulogiannis G, McIntyre RE, Dimitriadi M, Apps JR, Wilson CH, Ichimura K, Luo F, Cantley LC, Wyllie AH, Adams DJ, Arends MJ
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15145-50.
journal title abbreviation: Proc Natl Acad Sci U S A
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The role of lipid-derived second messengers in cell growth and transformation.
PubMed Identifier: 2835058
author list: Cantley L, Fleischman L, Whitman M
published in: Anti-cancer drug design
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journal title abbreviation: Anticancer Drug Des
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Ionic regulation of MEL cell commitment.
PubMed Identifier: 6575972
author list: Levenson R, Macara I, Cantley L, Housman D
published in: Journal of cellular biochemistry
information resource reference: Ionic regulation of MEL cell commitment. J Cell Biochem. 1983; 21(1):1-8.
journal title abbreviation: J Cell Biochem
publication date: 1983-01-01T00:00:00
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Rho family GTPases bind to phosphoinositide kinases.
PubMed Identifier: 7629060
author list: Tolias KF, Cantley LC, Carpenter CL
published in: The Journal of biological chemistry
information resource reference: Rho family GTPases bind to phosphoinositide kinases. J Biol Chem. 1995 Jul 28; 270(30):17656-9.
journal title abbreviation: J Biol Chem
publication date: 1995-07-28T00:00:00
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Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals.
PubMed Identifier: 7889566
author list: Klingmüller U, Lorenz U, Cantley LC, Neel BG, Lodish HF
published in: Cell
information resource reference: Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell. 1995 Mar 10; 80(5):729-38.
journal title abbreviation: Cell
publication date: 1995-03-10T00:00:00
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A murine genomic DNA fragment amplifies ouabain-induced Na,K-ATPase alpha/beta-subunit mRNA up-regulation and confers ouabain resistance.
PubMed Identifier: 8382694
author list: Zhou XM, Cunha MJ, Epstein J, Levenson R, Cantley LC, Cantley LG
published in: The Journal of biological chemistry
information resource reference: A murine genomic DNA fragment amplifies ouabain-induced Na,K-ATPase alpha/beta-subunit mRNA up-regulation and confers ouabain resistance. J Biol Chem. 1993 Feb 25; 268(6):4126-33.
journal title abbreviation: J Biol Chem
publication date: 1993-02-25T00:00:00
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Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate.
PubMed Identifier: 9660759
author list: Tolias KF, Rameh LE, Ishihara H, Shibasaki Y, Chen J, Prestwich GD, Cantley LC, Carpenter CL
published in: The Journal of biological chemistry
information resource reference: Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate. J Biol Chem. 1998 Jul 17; 273(29):18040-6.
journal title abbreviation: J Biol Chem
publication date: 1998-07-17T00:00:00
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ATM and lymphoid malignancies; use of oriented peptide libraries to identify novel substrates of ATM critical in downstream signaling pathways.
PubMed Identifier: 10396065
author list: Rathbun GA, Ziv Y, Lai JH, Hill D, Abraham RH, Shiloh Y, Cantley LC
published in: Current topics in microbiology and immunology
information resource reference: ATM and lymphoid malignancies; use of oriented peptide libraries to identify novel substrates of ATM critical in downstream signaling pathways. Curr Top Microbiol Immunol. 1999; 246:267-73; discussion 274.
journal title abbreviation: Curr Top Microbiol Immunol
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year: 1999
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Signal transduction. Grabbing phosphoproteins.
PubMed Identifier: 10573413
author list: Yaffe MB, Cantley LC
published in: Nature
information resource reference: Signal transduction. Grabbing phosphoproteins. Nature. 1999 Nov 04; 402(6757):30-1.
journal title abbreviation: Nature
publication date: 1999-11-04T00:00:00
year: 1999
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The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.
PubMed Identifier: 14532005
author list: Elia AE, Rellos P, Haire LF, Chao JW, Ivins FJ, Hoepker K, Mohammad D, Cantley LC, Smerdon SJ, Yaffe MB
published in: Cell
information resource reference: The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain. Cell. 2003 Oct 03; 115(1):83-95.
journal title abbreviation: Cell
publication date: 2003-10-03T00:00:00
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ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines.
PubMed Identifier: 15731348
author list: Engelman JA, Jänne PA, Mermel C, Pearlberg J, Mukohara T, Fleet C, Cichowski K, Johnson BE, Cantley LC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3788-93.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2005-02-24T00:00:00
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Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase.
PubMed Identifier: 17071741
author list: Oak JS, Deane JA, Kharas MG, Luo J, Lane TE, Cantley LC, Fruman DA
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16882-7.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2006-10-27T00:00:00
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T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling.
PubMed Identifier: 17164340
author list: Deane JA, Kharas MG, Oak JS, Stiles LN, Luo J, Moore TI, Ji H, Rommel C, Cantley LC, Lane TE, Fruman DA
published in: Blood
information resource reference: T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling. Blood. 2007 Apr 01; 109(7):2894-902.
journal title abbreviation: Blood
publication date: 2007-04-01T00:00:00
year: 2007
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type: Document
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Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry.
PubMed Identifier: 17431180
author list: Asara JM, Schweitzer MH, Freimark LM, Phillips M, Cantley LC
published in: Science (New York, N.Y.)
information resource reference: Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry. Science. 2007 Apr 13; 316(5822):280-5.
journal title abbreviation: Science
publication date: 2007-04-13T00:00:00
year: 2007
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type: Article
type: Document
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Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.
PubMed Identifier: 19819947
author list: Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ, Elmquist JK
published in: Endocrinology
information resource reference: Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. Endocrinology. 2009 Nov; 150(11):4874-82.
journal title abbreviation: Endocrinology
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Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.
PubMed Identifier: 19920251
author list: Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ, Xie J, Gu TL, Polakiewicz RD, Roesel JL, Boggon TJ, Khuri FR, Gilliland DG, Cantley LC, Kaufman J, Chen J
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Growth factor and oncogene influences on cell growth regulation.
PubMed Identifier: 2854424
author list: Serunian LA, Cantley LC
published in: Annals of the New York Academy of Sciences
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journal title abbreviation: Ann N Y Acad Sci
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Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers.
PubMed Identifier: 21985784
author list: Ebi H, Corcoran RB, Singh A, Chen Z, Song Y, Lifshits E, Ryan DP, Meyerhardt JA, Benes C, Settleman J, Wong KK, Cantley LC, Engelman JA
published in: The Journal of clinical investigation
information resource reference: Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers. J Clin Invest. 2011 Nov; 121(11):4311-21.
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Delta endotoxin inhibits Rb+ uptake, lowers cytoplasmic pH and inhibits a K+-ATPase in Manduca sexta CHE cells.
PubMed Identifier: 2993627
author list: English LH, Cantley LC
published in: The Journal of membrane biology
information resource reference: Delta endotoxin inhibits Rb+ uptake, lowers cytoplasmic pH and inhibits a K+-ATPase in Manduca sexta CHE cells. J Membr Biol. 1985; 85(3):199-204.
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Protein kinase C of human erythrocytes phosphorylates bands 4.1 and 4.9.
PubMed Identifier: 3013320
author list: Faquin WC, Chahwala SB, Cantley LC, Branton D
published in: Biochimica et biophysica acta
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Location of binding sites on the (Na,K)-ATPase for fluorescein-5'-isothiocyanate and ouabain.
PubMed Identifier: 6301338
author list: Cantley L, Carilli CT, Farley RA, Perlman DM
published in: Annals of the New York Academy of Sciences
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Identification of efficient pentapeptide substrates for the tyrosine kinase pp60c-src.
PubMed Identifier: 7473555
author list: Nair SA, Kim MH, Warren SD, Choi S, Songyang Z, Cantley LC, Hangauer DG
published in: Journal of medicinal chemistry
information resource reference: Identification of efficient pentapeptide substrates for the tyrosine kinase pp60c-src. J Med Chem. 1995 Oct 13; 38(21):4276-83.
journal title abbreviation: J Med Chem
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Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins.
PubMed Identifier: 7537362
author list: Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M
published in: Oncogene
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Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.
PubMed Identifier: 7798235
author list: Toker A, Meyer M, Reddy KK, Falck JR, Aneja R, Aneja S, Parra A, Burns DJ, Ballas LM, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. J Biol Chem. 1994 Dec 23; 269(51):32358-67.
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Regulation of CD4-p56lck-associated phosphatidylinositol 3-kinase (PI 3-kinase) and phosphatidylinositol 4-kinase (PI 4-kinase).
PubMed Identifier: 7904344
author list: Prasad KV, Kapeller R, Janssen O, Duke-Cohan JS, Repke H, Cantley LC, Rudd CE
published in: Philosophical transactions of the Royal Society of London. Series B, Biological sciences
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Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity.
PubMed Identifier: 8065326
author list: Yoakim M, Hou W, Songyang Z, Liu Y, Cantley L, Schaffhausen B
published in: Molecular and cellular biology
information resource reference: Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity. Mol Cell Biol. 1994 Sep; 14(9):5929-38.
journal title abbreviation: Mol Cell Biol
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Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.
PubMed Identifier: 8246987
author list: Prasad KV, Kapeller R, Janssen O, Repke H, Duke-Cohan JS, Cantley LC, Rudd CE
published in: Molecular and cellular biology
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Two distinct cytosolic calcium responses to extracellular ATP in rat parotid acinar cells.
PubMed Identifier: 8448596
author list: McMillian MK, Soltoff SP, Cantley LC, Rudel R, Talamo BR
published in: British journal of pharmacology
information resource reference: Two distinct cytosolic calcium responses to extracellular ATP in rat parotid acinar cells. Br J Pharmacol. 1993 Feb; 108(2):453-61.
journal title abbreviation: Br J Pharmacol
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Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis.
PubMed Identifier: 11696584
author list: Singh VP, Saluja AK, Bhagat L, van Acker GJ, Song AM, Soltoff SP, Cantley LC, Steer ML
published in: The Journal of clinical investigation
information resource reference: Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis. J Clin Invest. 2001 Nov; 108(9):1387-95.
journal title abbreviation: J Clin Invest
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A motif-based profile scanning approach for genome-wide prediction of signaling pathways.
PubMed Identifier: 11283593
author list: Yaffe MB, Leparc GG, Lai J, Obata T, Volinia S, Cantley LC
published in: Nature biotechnology
information resource reference: A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nat Biotechnol. 2001 Apr; 19(4):348-53.
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Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation.
PubMed Identifier: 1649958
author list: Serunian LA, Auger KR, Cantley LC
published in: Methods in enzymology
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Using peptide libraries to identify optimal cleavage motifs for proteolytic enzymes.
PubMed Identifier: 15003602
author list: Turk BE, Cantley LC
published in: Methods (San Diego, Calif.)
information resource reference: Using peptide libraries to identify optimal cleavage motifs for proteolytic enzymes. Methods. 2004 Apr; 32(4):398-405.
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Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2.
PubMed Identifier: 16027169
author list: Manning BD, Logsdon MN, Lipovsky AI, Abbott D, Kwiatkowski DJ, Cantley LC
published in: Genes & development
information resource reference: Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Genes Dev. 2005 Aug 01; 19(15):1773-8.
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Rapid release of bound glucose-6-phosphate dehydrogenase by growth factors. Correlation with increased enzymatic activity.
PubMed Identifier: 2061319
author list: Stanton RC, Seifter JL, Boxer DC, Zimmerman E, Cantley LC
published in: The Journal of biological chemistry
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Production of novel polyphosphoinositides in vivo is linked to cell transformation by polyomavirus middle T antigen.
PubMed Identifier: 2168961
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published in: Journal of virology
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Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates.
PubMed Identifier: 17406259
author list: Turk BE, Hutti JE, Cantley LC
published in: Nature protocols
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The phosphoinositide 3-kinase pathway.
PubMed Identifier: 12040186
author list: Cantley LC
published in: Science (New York, N.Y.)
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A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity.
PubMed Identifier: 12080346
author list: Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, Bourne HR
published in: Nature cell biology
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journal title abbreviation: Nat Cell Biol
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Hitting the target: emerging technologies in the search for kinase substrates.
PubMed Identifier: 12475999
author list: Manning BD, Cantley LC
published in: Science's STKE : signal transduction knowledge environment
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United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling.
PubMed Identifier: 12773158
author list: Manning BD, Cantley LC
published in: Biochemical Society transactions
information resource reference: United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling. Biochem Soc Trans. 2003 Jun; 31(Pt 3):573-8.
journal title abbreviation: Biochem Soc Trans
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Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs.
PubMed Identifier: 12824383
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published in: Nucleic acids research
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A monoclonal antibody distinguishes two types of phosphatidylinositol 4-kinase.
PubMed Identifier: 1846531
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published in: The Biochemical journal
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Effects of muscarinic, alpha-adrenergic, and substance P agonists and ionomycin on ion transport mechanisms in the rat parotid acinar cell. The dependence of ion transport on intracellular calcium.
PubMed Identifier: 2467962
author list: Soltoff SP, McMillian MK, Cantley LC, Cragoe EJ, Talamo BR
published in: The Journal of general physiology
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The antiproliferative cytostatic effects of a self-activating viridin prodrug.
PubMed Identifier: 19509266
author list: Smith A, Blois J, Yuan H, Aikawa E, Ellson C, Figueiredo JL, Weissleder R, Kohler R, Yaffe MB, Cantley LC, Josephson L
published in: Molecular cancer therapeutics
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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
PubMed Identifier: 20559394
author list: Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD, Cantley LC, Thompson CB, Vander Heiden MG, Su SM
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AKT/PKB signaling: navigating downstream.
PubMed Identifier: 17604717
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published in: Cell
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Fate of a bioactive fluorescent wortmannin derivative in cells.
PubMed Identifier: 17988080
author list: Barnes KR, Blois J, Smith A, Yuan H, Reynolds F, Weissleder R, Cantley LC, Josephson L
published in: Bioconjugate chemistry
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journal title abbreviation: Bioconjug Chem
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Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.
PubMed Identifier: 23142078
author list: Kim SG, Hoffman GR, Poulogiannis G, Buel GR, Jang YJ, Lee KW, Kim BY, Erikson RL, Cantley LC, Choo AY, Blenis J
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High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif.
PubMed Identifier: 9207069
author list: Li SC, Songyang Z, Vincent SJ, Zwahlen C, Wiley S, Cantley L, Kay LE, Forman-Kay J, Pawson T
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Identification and characterization of a phosphoinositide phosphate kinase homolog.
PubMed Identifier: 14701839
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journal title abbreviation: J Biol Chem
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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
PubMed Identifier: 14985505
author list: Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A. 2004 Mar 09; 101(10):3329-35.
journal title abbreviation: Proc Natl Acad Sci U S A
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The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape.
PubMed Identifier: 15985609
author list: Kang CM, Abbott DW, Park ST, Dascher CC, Cantley LC, Husson RN
published in: Genes & development
information resource reference: The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Genes Dev. 2005 Jul 15; 19(14):1692-704.
journal title abbreviation: Genes Dev
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Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer.
PubMed Identifier: 16906227
author list: Engelman JA, Mukohara T, Zejnullahu K, Lifshits E, Borrás AM, Gale CM, Naumov GN, Yeap BY, Jarrell E, Sun J, Tracy S, Zhao X, Heymach JV, Johnson BE, Cantley LC, Jänne PA
published in: The Journal of clinical investigation
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journal title abbreviation: J Clin Invest
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SYK is upstream of phosphoinositide 3-kinase in B cell receptor signaling.
PubMed Identifier: 10551821
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Isolation of a potent (Na-K)ATPase inhibitor from striated muscle.
PubMed Identifier: 143955
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Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation.
PubMed Identifier: 7744773
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Lipid research picks up speed on the slopes of Taos.
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Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase.
PubMed Identifier: 1713578
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Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants.
PubMed Identifier: 1846663
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Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice.
PubMed Identifier: 15143198
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Breathless cancer cells get fat on glutamine.
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T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.
PubMed Identifier: 8146197
author list: Prasad KV, Cai YC, Raab M, Duckworth B, Cantley L, Shoelson SE, Rudd CE
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. Proc Natl Acad Sci U S A. 1994 Mar 29; 91(7):2834-8.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1994-03-29T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis.
PubMed Identifier: 17349956
author list: Holt LJ, Hutti JE, Cantley LC, Morgan DO
published in: Molecular cell
information resource reference: Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis. Mol Cell. 2007 Mar 09; 25(5):689-702.
journal title abbreviation: Mol Cell
publication date: 2007-03-09T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway.
PubMed Identifier: 17709380
author list: Hutti JE, Turk BE, Asara JM, Ma A, Cantley LC, Abbott DW
published in: Molecular and cellular biology
information resource reference: IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway. Mol Cell Biol. 2007 Nov; 27(21):7451-61.
journal title abbreviation: Mol Cell Biol
publication date: 2007-08-20T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Expression of an ouabain resistance gene in transfected cells. Ouabain treatment induces a K+-transport system.
PubMed Identifier: 2981832
author list: English LH, Epstein J, Cantley L, Housman D, Levenson R
published in: The Journal of biological chemistry
information resource reference: Expression of an ouabain resistance gene in transfected cells. Ouabain treatment induces a K+-transport system. J Biol Chem. 1985 Jan 25; 260(2):1114-9.
journal title abbreviation: J Biol Chem
publication date: 1985-01-25T00:00:00
year: 1985
type: Academic Article
type: Article
type: Document
type: Information Resource

Structural aspects of the red cell anion exchange protein.
PubMed Identifier: 3527050
author list: Jay D, Cantley L
published in: Annual review of biochemistry
information resource reference: Structural aspects of the red cell anion exchange protein. Annu Rev Biochem. 1986; 55:511-38.
journal title abbreviation: Annu Rev Biochem
publication date: 1986-01-01T00:00:00
year: 1986
type: Academic Article
type: Article
type: Document
type: Information Resource

Cloning and characterization of a human phosphatidylinositol 4-kinase.
PubMed Identifier: 7961848
author list: Wong K, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Cloning and characterization of a human phosphatidylinositol 4-kinase. J Biol Chem. 1994 Nov 18; 269(46):28878-84.
journal title abbreviation: J Biol Chem
publication date: 1994-11-18T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Recognition and specificity in protein tyrosine kinase-mediated signalling.
PubMed Identifier: 8578591
author list: Songyang Z, Cantley LC
published in: Trends in biochemical sciences
information resource reference: Recognition and specificity in protein tyrosine kinase-mediated signalling. Trends Biochem Sci. 1995 Nov; 20(11):470-5.
journal title abbreviation: Trends Biochem Sci
publication date: 1995-11-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Class 1A PI3K regulates vessel integrity during development and tumorigenesis.
PubMed Identifier: 18621722
author list: Yuan TL, Choi HS, Matsui A, Benes C, Lifshits E, Luo J, Frangioni JV, Cantley LC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Class 1A PI3K regulates vessel integrity during development and tumorigenesis. Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28):9739-44.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2008-07-10T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphoinositide metabolism and the control of cell proliferation.
PubMed Identifier: 2537660
author list: Whitman M, Cantley L
published in: Biochimica et biophysica acta
information resource reference: Phosphoinositide metabolism and the control of cell proliferation. Biochim Biophys Acta. 1989 Feb; 948(3):327-44.
journal title abbreviation: Biochim Biophys Acta
publication date: 1989-02-01T00:00:00
year: 1989
type: Academic Article
type: Article
type: Document
type: Information Resource

Membrane biochemistry of the ouabain-resistant potassium transport system.
PubMed Identifier: 2824373
author list: English LH, White B, Cantley LC
published in: Hypertension (Dallas, Tex. : 1979)
information resource reference: Membrane biochemistry of the ouabain-resistant potassium transport system. Hypertension. 1987 Nov; 10(5 Pt 2):I93-4.
journal title abbreviation: Hypertension
publication date: 1987-11-01T00:00:00
year: 1987
type: Academic Article
type: Article
type: Document
type: Information Resource

Using tandem mass spectrometry in targeted mode to identify activators of class IA PI3K in cancer.
PubMed Identifier: 21775521
author list: Yang X, Turke AB, Qi J, Song Y, Rexer BN, Miller TW, Jänne PA, Arteaga CL, Cantley LC, Engelman JA, Asara JM
published in: Cancer research
information resource reference: Using tandem mass spectrometry in targeted mode to identify activators of class IA PI3K in cancer. Cancer Res. 2011 Sep 15; 71(18):5965-75.
journal title abbreviation: Cancer Res
publication date: 2011-07-20T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.
PubMed Identifier: 20530665
author list: Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Alemán JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR
published in: Cancer research
information resource reference: The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling. Cancer Res. 2010 Jul 01; 70(13):5305-15.
journal title abbreviation: Cancer Res
publication date: 2010-06-08T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

ras-transformed cells: altered levels of phosphatidylinositol-4,5-bisphosphate and catabolites.
PubMed Identifier: 3001936
author list: Fleischman LF, Chahwala SB, Cantley L
published in: Science (New York, N.Y.)
information resource reference: ras-transformed cells: altered levels of phosphatidylinositol-4,5-bisphosphate and catabolites. Science. 1986 Jan 24; 231(4736):407-10.
journal title abbreviation: Science
publication date: 1986-01-24T00:00:00
year: 1986
type: Academic Article
type: Article
type: Document
type: Information Resource

Interactions between transport inhibitors at the anion binding sites of the band 3 dimer.
PubMed Identifier: 7295667
author list: Macara IG, Cantley LC
published in: Biochemistry
information resource reference: Interactions between transport inhibitors at the anion binding sites of the band 3 dimer. Biochemistry. 1981 Sep 01; 20(18):5095-105.
journal title abbreviation: Biochemistry
publication date: 1981-09-01T00:00:00
year: 1981
type: Academic Article
type: Article
type: Document
type: Information Resource

SH2 domain specificity and activity modified by a single residue.
PubMed Identifier: 7515480
author list: Marengere LE, Songyang Z, Gish GD, Schaller MD, Parsons JT, Stern MJ, Cantley LC, Pawson T
published in: Nature
information resource reference: SH2 domain specificity and activity modified by a single residue. Nature. 1994 Jun 09; 369(6480):502-5.
journal title abbreviation: Nature
publication date: 1994-06-09T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Phosphatidylinositol 3-kinase.
PubMed Identifier: 8086005
author list: Kapeller R, Cantley LC
published in: BioEssays : news and reviews in molecular, cellular and developmental biology
information resource reference: Phosphatidylinositol 3-kinase. Bioessays. 1994 Aug; 16(8):565-76.
journal title abbreviation: Bioessays
publication date: 1994-08-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity.
PubMed Identifier: 8382773
author list: Carpenter CL, Auger KR, Duckworth BC, Hou WM, Schaffhausen B, Cantley LC
published in: Molecular and cellular biology
information resource reference: A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity. Mol Cell Biol. 1993 Mar; 13(3):1657-65.
journal title abbreviation: Mol Cell Biol
publication date: 1993-03-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells.
PubMed Identifier: 8550620
author list: Soltoff SP, Cantley LC
published in: The Journal of biological chemistry
information resource reference: p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells. J Biol Chem. 1996 Jan 05; 271(1):563-7.
journal title abbreviation: J Biol Chem
publication date: 1996-01-05T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.
PubMed Identifier: 19647222
author list: Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC
published in: Cancer cell
information resource reference: Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell. 2009 Aug 04; 16(2):115-25.
journal title abbreviation: Cancer Cell
publication date: 2009-08-04T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.
PubMed Identifier: 19935646
author list: Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD, Cantley LC, Thompson CB, Vander Heiden MG, Su SM
published in: Nature
information resource reference: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009 Dec 10; 462(7274):739-44.
journal title abbreviation: Nature
publication date: 2009-12-10T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size.
PubMed Identifier: 21474067
author list: Saci A, Cantley LC, Carpenter CL
published in: Molecular cell
information resource reference: Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. Mol Cell. 2011 Apr 08; 42(1):50-61.
journal title abbreviation: Mol Cell
publication date: 2011-04-08T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival.
PubMed Identifier: 21854985
author list: Yi CH, Pan H, Seebacher J, Jang IH, Hyberts SG, Heffron GJ, Vander Heiden MG, Yang R, Li F, Locasale JW, Sharfi H, Zhai B, Rodriguez-Mias R, Luithardt H, Cantley LC, Daley GQ, Asara JM, Gygi SP, Wagner G, Liu CF, Yuan J
published in: Cell
information resource reference: Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell. 2011 Aug 19; 146(4):607-20.
journal title abbreviation: Cell
publication date: 2011-08-19T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Ion fluxes and differentiation in transformed cell lines.
PubMed Identifier: 2984780
author list: Rosoff PM, Cantley LC
published in: Society of General Physiologists series
information resource reference: Ion fluxes and differentiation in transformed cell lines. Soc Gen Physiol Ser. 1985; 39:193-204.
journal title abbreviation: Soc Gen Physiol Ser
publication date: 1985-01-01T00:00:00
year: 1985
type: Academic Article
type: Article
type: Document
type: Information Resource

Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains.
PubMed Identifier: 17562858
author list: Abbott DW, Yang Y, Hutti JE, Madhavarapu S, Kelliher MA, Cantley LC
published in: Molecular and cellular biology
information resource reference: Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains. Mol Cell Biol. 2007 Sep; 27(17):6012-25.
journal title abbreviation: Mol Cell Biol
publication date: 2007-06-11T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Slow self-activation enhances the potency of viridin prodrugs.
PubMed Identifier: 18630894
author list: Blois J, Yuan H, Smith A, Pacold ME, Weissleder R, Cantley LC, Josephson L
published in: Journal of medicinal chemistry
information resource reference: Slow self-activation enhances the potency of viridin prodrugs. J Med Chem. 2008 Aug 14; 51(15):4699-707.
journal title abbreviation: J Med Chem
publication date: 2008-07-17T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn.
PubMed Identifier: 7520528
author list: Panchamoorthy G, Fukazawa T, Stolz L, Payne G, Reedquist K, Shoelson S, Songyang Z, Cantley L, Walsh C, Band H
published in: Molecular and cellular biology
information resource reference: Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn. Mol Cell Biol. 1994 Sep; 14(9):6372-85.
journal title abbreviation: Mol Cell Biol
publication date: 1994-09-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Signal transduction by the hepatocyte growth factor receptor, c-met. Activation of the phosphatidylinositol 3-kinase.
PubMed Identifier: 7620084
author list: Cantley LG, Cantley LC
published in: Journal of the American Society of Nephrology : JASN
information resource reference: Signal transduction by the hepatocyte growth factor receptor, c-met. Activation of the phosphatidylinositol 3-kinase. J Am Soc Nephrol. 1995 May; 5(11):1872-81.
journal title abbreviation: J Am Soc Nephrol
publication date: 1995-05-01T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase.
PubMed Identifier: 7642581
author list: Fukazawa T, Reedquist KA, Trub T, Soltoff S, Panchamoorthy G, Druker B, Cantley L, Shoelson SE, Band H
published in: The Journal of biological chemistry
information resource reference: The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase. J Biol Chem. 1995 Aug 11; 270(32):19141-50.
journal title abbreviation: J Biol Chem
publication date: 1995-08-11T00:00:00
year: 1995
type: Academic Article
type: Article
type: Document
type: Information Resource

Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells.
PubMed Identifier: 8392933
author list: Corey S, Eguinoa A, Puyana-Theall K, Bolen JB, Cantley L, Mollinedo F, Jackson TR, Hawkins PT, Stephens LR
published in: The EMBO journal
information resource reference: Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells. EMBO J. 1993 Jul; 12(7):2681-90.
journal title abbreviation: EMBO J
publication date: 1993-07-01T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource

Specificity of LIM domain interactions with receptor tyrosine kinases.
PubMed Identifier: 8663233
author list: Wu R, Durick K, Songyang Z, Cantley LC, Taylor SS, Gill GN
published in: The Journal of biological chemistry
information resource reference: Specificity of LIM domain interactions with receptor tyrosine kinases. J Biol Chem. 1996 Jul 05; 271(27):15934-41.
journal title abbreviation: J Biol Chem
publication date: 1996-07-05T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation.
PubMed Identifier: 19187764
author list: Zheng B, Jeong JH, Asara JM, Yuan YY, Granter SR, Chin L, Cantley LC
published in: Molecular cell
information resource reference: Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. Mol Cell. 2009 Jan 30; 33(2):237-47.
journal title abbreviation: Mol Cell
publication date: 2009-01-30T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation.
PubMed Identifier: 2987699
author list: Whitman M, Kaplan DR, Schaffhausen B, Cantley L, Roberts TM
published in: Nature
information resource reference: Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation. Nature. 1985 May 16-22; 315(6016):239-42.
journal title abbreviation: Nature
publication date: 1985-05-01T00:00:00
year: 1985
type: Academic Article
type: Article
type: Document
type: Information Resource

SIRT6 puts cancer metabolism in the driver's seat.
PubMed Identifier: 23217699
author list: Lyssiotis CA, Cantley LC
published in: Cell
information resource reference: SIRT6 puts cancer metabolism in the driver's seat. Cell. 2012 Dec 07; 151(6):1155-6.
journal title abbreviation: Cell
publication date: 2012-12-07T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts.
PubMed Identifier: 9490725
author list: Ma L, Cantley LC, Janmey PA, Kirschner MW
published in: The Journal of cell biology
information resource reference: Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts. J Cell Biol. 1998 Mar 09; 140(5):1125-36.
journal title abbreviation: J Cell Biol
publication date: 1998-03-09T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Reaction of (Na-K)ATPase with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole: evidence for an essential tyrosine at the active site.
PubMed Identifier: 145873
author list: Cantley LC, Gelles J, Josephson L
published in: Biochemistry
information resource reference: Reaction of (Na-K)ATPase with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole: evidence for an essential tyrosine at the active site. Biochemistry. 1978 Feb 07; 17(3):418-25.
journal title abbreviation: Biochemistry
publication date: 1978-02-07T00:00:00
year: 1978
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 108617
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Rheb fills a GAP between TSC and TOR.

Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation.
PubMed Identifier: 11581283
author list: Vieira OV, Botelho RJ, Rameh L, Brachmann SM, Matsuo T, Davidson HW, Schreiber A, Backer JM, Cantley LC, Grinstein S
published in: The Journal of cell biology
information resource reference: Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. J Cell Biol. 2001 Oct 01; 155(1):19-25.
journal title abbreviation: J Cell Biol
publication date: 2001-10-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Interferon regulatory factor-3 is an in vivo target of DNA-PK.
PubMed Identifier: 11867762
author list: Karpova AY, Trost M, Murray JM, Cantley LC, Howley PM
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Interferon regulatory factor-3 is an in vivo target of DNA-PK. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2818-23.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2002-02-26T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Peptide libraries: at the crossroads of proteomics and bioinformatics.
PubMed Identifier: 12547431
author list: Turk BE, Cantley LC
published in: Current opinion in chemical biology
information resource reference: Peptide libraries: at the crossroads of proteomics and bioinformatics. Curr Opin Chem Biol. 2003 Feb; 7(1):84-90.
journal title abbreviation: Curr Opin Chem Biol
publication date: 2003-02-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions.
PubMed Identifier: 12734182
author list: Katome T, Obata T, Matsushima R, Masuyama N, Cantley LC, Gotoh Y, Kishi K, Shiota H, Ebina Y
published in: The Journal of biological chemistry
information resource reference: Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions. J Biol Chem. 2003 Jul 25; 278(30):28312-23.
journal title abbreviation: J Biol Chem
publication date: 2003-05-06T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling.
PubMed Identifier: 14504291
author list: Ueki K, Fruman DA, Yballe CM, Fasshauer M, Klein J, Asano T, Cantley LC, Kahn CR
published in: The Journal of biological chemistry
information resource reference: Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling. J Biol Chem. 2003 Nov 28; 278(48):48453-66.
journal title abbreviation: J Biol Chem
publication date: 2003-09-22T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO.
PubMed Identifier: 15620648
author list: Abbott DW, Wilkins A, Asara JM, Cantley LC
published in: Current biology : CB
information resource reference: The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO. Curr Biol. 2004 Dec 29; 14(24):2217-27.
journal title abbreviation: Curr Biol
publication date: 2004-12-29T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Apoptosis. A Bad kinase makes good.
PubMed Identifier: 9367147
author list: Franke TF, Cantley LC
published in: Nature
information resource reference: Apoptosis. A Bad kinase makes good. Nature. 1997 Nov 13; 390(6656):116-7.
journal title abbreviation: Nature
publication date: 1997-11-13T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro.
PubMed Identifier: 1372000
author list: Auger KR, Carpenter CL, Shoelson SE, Piwnica-Worms H, Cantley LC
published in: The Journal of biological chemistry
information resource reference: Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro. J Biol Chem. 1992 Mar 15; 267(8):5408-15.
journal title abbreviation: J Biol Chem
publication date: 1992-03-15T00:00:00
year: 1992
type: Academic Article
type: Article
type: Document
type: Information Resource

A flattened face for membranes.
PubMed Identifier: 9783737
author list: Carpenter CL, Cantley LC
published in: Nature structural biology
information resource reference: A flattened face for membranes. Nat Struct Biol. 1998 Oct; 5(10):843-5.
journal title abbreviation: Nat Struct Biol
publication date: 1998-10-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.
PubMed Identifier: 9888855
author list: Fruman DA, Snapper SB, Yballe CM, Davidson L, Yu JY, Alt FW, Cantley LC
published in: Science (New York, N.Y.)
information resource reference: Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science. 1999 Jan 15; 283(5400):393-7.
journal title abbreviation: Science
publication date: 1999-01-15T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Ras, PI(3)K and mTOR signalling controls tumour cell growth.
PubMed Identifier: 16724053
author list: Shaw RJ, Cantley LC
published in: Nature
information resource reference: Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature. 2006 May 25; 441(7092):424-30.
journal title abbreviation: Nature
publication date: 2006-05-25T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

The role of the ErbB family members in non-small cell lung cancers sensitive to epidermal growth factor receptor kinase inhibitors.
PubMed Identifier: 16857813
author list: Engelman JA, Cantley LC
published in: Clinical cancer research : an official journal of the American Association for Cancer Research
information resource reference: The role of the ErbB family members in non-small cell lung cancers sensitive to epidermal growth factor receptor kinase inhibitors. Clin Cancer Res. 2006 Jul 15; 12(14 Pt 2):4372s-4376s.
journal title abbreviation: Clin Cancer Res
publication date: 2006-07-15T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.
PubMed Identifier: 9446795
author list: Borgatti P, Zauli G, Cantley LC, Capitani S
published in: Biochemical and biophysical research communications
information resource reference: Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. Biochem Biophys Res Commun. 1998 Jan 14; 242(2):332-7.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 1998-01-14T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Mouse phosphoinositide 3-kinase p110alpha gene: cloning, structural organization, and localization to chromosome 3 band B.
PubMed Identifier: 10462494
author list: Aksoy IA, Ramsey MJ, Fruman DA, Aksoy S, Cantley LC, Tucker JD, Roberts TM
published in: Biochemical and biophysical research communications
information resource reference: Mouse phosphoinositide 3-kinase p110alpha gene: cloning, structural organization, and localization to chromosome 3 band B. Biochem Biophys Res Commun. 1999 Aug 27; 262(2):438-42.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 1999-08-27T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

The active site structure of Na+- and K+-stimulated ATPase. Location of a specific fluorescein isothiocyanate reactive site.
PubMed Identifier: 6279607
author list: Carilli CT, Farley RA, Perlman DM, Cantley LC
published in: The Journal of biological chemistry
information resource reference: The active site structure of Na+- and K+-stimulated ATPase. Location of a specific fluorescein isothiocyanate reactive site. J Biol Chem. 1982 May 25; 257(10):5601-6.
journal title abbreviation: J Biol Chem
publication date: 1982-05-25T00:00:00
year: 1982
type: Academic Article
type: Article
type: Document
type: Information Resource

Minimal activators that bind to the KIX domain of p300/CBP identified by phage display screening.
PubMed Identifier: 11017047
author list: Frangioni JV, LaRiccia LM, Cantley LC, Montminy MR
published in: Nature biotechnology
information resource reference: Minimal activators that bind to the KIX domain of p300/CBP identified by phage display screening. Nat Biotechnol. 2000 Oct; 18(10):1080-5.
journal title abbreviation: Nat Biotechnol
publication date: 2000-10-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates.
PubMed Identifier: 12595692
author list: Elia AE, Cantley LC, Yaffe MB
published in: Science (New York, N.Y.)
information resource reference: Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Science. 2003 Feb 21; 299(5610):1228-31.
journal title abbreviation: Science
publication date: 2003-02-21T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Rheb fills a GAP between TSC and TOR.
PubMed Identifier: 14607085
author list: Manning BD, Cantley LC
published in: Trends in biochemical sciences
information resource reference: Rheb fills a GAP between TSC and TOR. Trends Biochem Sci. 2003 Nov; 28(11):573-6.
journal title abbreviation: Trends Biochem Sci
publication date: 2003-11-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 100040
type: Authorship
author rank in publication: 2
linked author: Cantley, Lewis
linked information resource: Type 2 phosphatidylinositol 4-kinase is recruited to CD4 in response to CD4 cross-linking.

ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor.
PubMed Identifier: 7515147
author list: Soltoff SP, Carraway KL, Prigent SA, Gullick WG, Cantley LC
published in: Molecular and cellular biology
information resource reference: ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor. Mol Cell Biol. 1994 Jun; 14(6):3550-8.
journal title abbreviation: Mol Cell Biol
publication date: 1994-06-01T00:00:00
year: 1994
type: Academic Article
type: Article
type: Document
type: Information Resource

Blockade of ATP binding site of P2 purinoceptors in rat parotid acinar cells by isothiocyanate compounds.
PubMed Identifier: 7684222
author list: Soltoff SP, McMillian MK, Talamo BR, Cantley LC
published in: Biochemical pharmacology
information resource reference: Blockade of ATP binding site of P2 purinoceptors in rat parotid acinar cells by isothiocyanate compounds. Biochem Pharmacol. 1993 May 05; 45(9):1936-40.
journal title abbreviation: Biochem Pharmacol
publication date: 1993-05-05T00:00:00
year: 1993
type: Academic Article
type: Article
type: Document
type: Information Resource