Chiu, Isaac
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first name: Isaac
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Authorship 1051127
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author rank in publication: 13
linked author: Chiu, Isaac
linked information resource: Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia.

Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia.
PubMed Identifier: 29505031
author list: Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM
published in: Nature medicine
information resource reference: Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia. Nat Med. 2018 05; 24(4):417-426.
journal title abbreviation: Nat Med
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year: 2018
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linked author: Chiu, Isaac
linked information resource: Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection.

Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection.
PubMed Identifier: 29754819
author list: Pinho-Ribeiro FA, Baddal B, Haarsma R, O'Seaghdha M, Yang NJ, Blake KJ, Portley M, Verri WA, Dale JB, Wessels MR, Chiu IM
published in: Cell
information resource reference: Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection. Cell. 2018 05 17; 173(5):1083-1097.e22.
journal title abbreviation: Cell
publication date: 2018-05-10T00:00:00
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Identification of the target self-antigens in reperfusion injury.
PubMed Identifier: 16390934
author list: Zhang M, Alicot EM, Chiu I, Li J, Verna N, Vorup-Jensen T, Kessler B, Shimaoka M, Chan R, Friend D, Mahmood U, Weissleder R, Moore FD, Carroll MC
published in: The Journal of experimental medicine
information resource reference: Identification of the target self-antigens in reperfusion injury. J Exp Med. 2006 Jan 23; 203(1):141-52.
journal title abbreviation: J Exp Med
publication date: 2006-01-03T00:00:00
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Authorship 1079997
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linked author: Chiu, Isaac
linked information resource: Author Correction: Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia.

Author Correction: Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia.
PubMed Identifier: 30013196
author list: Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM
published in: Nature medicine
information resource reference: Author Correction: Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia. Nat Med. 2018 Oct; 24(10):1625-1626.
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Authorship 1119413
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linked author: Chiu, Isaac
linked information resource: Molecular link between itch and atopic dermatitis.

Molecular link between itch and atopic dermatitis.
PubMed Identifier: 30538205
author list: Voisin T, Chiu IM
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Molecular link between itch and atopic dermatitis. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):12851-12853.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2018-12-11T00:00:00
year: 2018
type: Academic Article
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https://connects.catalyst.harvard.edu/Profiles/profile/117511256
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linked author: Chiu, Isaac
linked information resource: Pain and immunity: implications for host defence.

Pain and immunity: implications for host defence.
PubMed Identifier: 30874629
author list: Baral P, Udit S, Chiu IM
published in: Nature reviews. Immunology
information resource reference: Pain and immunity: implications for host defence. Nat Rev Immunol. 2019 07; 19(7):433-447.
journal title abbreviation: Nat Rev Immunol
publication date: 2019-07-01T00:00:00
year: 2019
type: Academic Article
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Neuropeptides
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Immune System
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Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion.
PubMed Identifier: 31027995
author list: Leyva-Castillo JM, Galand C, Kam C, Burton O, Gurish M, Musser MA, Goldsmith JD, Hait E, Nurko S, Brombacher F, Dong C, Finkelman FD, Lee RT, Ziegler S, Chiu I, Austen KF, Geha RS
published in: Immunity
information resource reference: Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion. Immunity. 2019 05 21; 50(5):1262-1275.e4.
journal title abbreviation: Immunity
publication date: 2019-04-23T00:00:00
year: 2019
type: Academic Article
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Nociceptors
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linked information resource: Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion.

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Xavier, Ramnik
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linked information resource: Mast Cells Get on Your Nerves in Itch.

Mast Cells Get on Your Nerves in Itch.
PubMed Identifier: 31117004
author list: Voisin T, Chiu IM
published in: Immunity
information resource reference: Mast Cells Get on Your Nerves in Itch. Immunity. 2019 05 21; 50(5):1117-1119.
journal title abbreviation: Immunity
publication date: 2019-05-21T00:00:00
year: 2019
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Bourgeois, Blaise
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Wakimoto, Hiroko
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Burstein, Rami
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Michelson, Alan
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Woolf, Clifford
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person in primary position: Professor of Neurology
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Authorship 1162514
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author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: Neuronal Regulation of Immunity in the Skin and Lungs.

Neuronal Regulation of Immunity in the Skin and Lungs.
PubMed Identifier: 31213389
author list: Blake KJ, Jiang XR, Chiu IM
published in: Trends in neurosciences
information resource reference: Neuronal Regulation of Immunity in the Skin and Lungs. Trends Neurosci. 2019 08; 42(8):537-551.
journal title abbreviation: Trends Neurosci
publication date: 2019-06-15T00:00:00
year: 2019
type: Academic Article
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type: Document
type: Information Resource

Sokol, Caroline
eCommons Login: CLS24
first name: Caroline
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McIntosh, Ken
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Kuchroo, Vijay
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person in primary position: Samuel L. Wasserstrom Professor of Neurology
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Mechanistic studies on analgesic effects of terpene enriched extracts from hops
end date: 2021-08-31
principal investigator name: QUAVE, CASSANDRA LEAH
start date: 2019-09-15
type: Grant
sponsor award id: R21AT010774

Co-Principal Investigator
type: Researcher Role
researcher role of: Chiu, Isaac
contributes to: Mechanistic studies on analgesic effects of terpene enriched extracts from hops

Authorship 1198005
type: Authorship
author rank in publication: 14
linked author: Chiu, Isaac
linked information resource: Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses.

Authorship 1196857
type: Authorship
author rank in publication: 2
linked author: Chiu, Isaac
linked information resource: Nociceptor nerves set the stage for skin immunity.

Nociceptor nerves set the stage for skin immunity.
PubMed Identifier: 31619764
author list: Pinho-Ribeiro FA, Chiu IM
published in: Cell research
information resource reference: Nociceptor nerves set the stage for skin immunity. Cell Res. 2019 11; 29(11):877-878.
journal title abbreviation: Cell Res
publication date: 2019-11-01T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses.
PubMed Identifier: 31604686
author list: Wallrapp A, Burkett PR, Riesenfeld SJ, Kim SJ, Christian E, Abdulnour RE, Thakore PI, Schnell A, Lambden C, Herbst RH, Khan P, Tsujikawa K, Xavier RJ, Chiu IM, Levy BD, Regev A, Kuchroo VK
published in: Immunity
information resource reference: Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses. Immunity. 2019 10 15; 51(4):709-723.e6.
journal title abbreviation: Immunity
publication date: 2019-10-08T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Instructor in Genetics
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position in organization: Harvard Medical School

Neel, Dylan
eCommons Login: DVN2
first name: Dylan
last name: Neel
full name: Dylan Neel, M.D., Ph.D.
has faculty rank: Fellow or Post Doc
Person ID: 148556
person in primary position: Clinical Fellow in Medicine
type: Agent
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preferred title: Clinical Fellow in Medicine

Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense.
PubMed Identifier: 31813624
author list: Lai NY, Musser MA, Pinho-Ribeiro FA, Baral P, Jacobson A, Ma P, Potts DE, Chen Z, Paik D, Soualhi S, Yan Y, Misra A, Goldstein K, Lagomarsino VN, Nordstrom A, Sivanathan KN, Wallrapp A, Kuchroo VK, Nowarski R, Starnbach MN, Shi H, Surana NK, An D, Wu C, Huh JR, Rao M, Chiu IM
published in: Cell
information resource reference: Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense. Cell. 2020 01 09; 180(1):33-49.e22.
journal title abbreviation: Cell
publication date: 2019-12-05T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1212824
type: Authorship
author rank in publication: 27
linked author: Chiu, Isaac
linked information resource: Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense.

Authorship 1220672
type: Authorship
author rank in publication: 15
linked author: Chiu, Isaac
linked information resource: Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells.

Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells.
PubMed Identifier: 31969699
author list: Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, Gonçalves WA, Shwartz Y, Fast EM, Su Y, Zon LI, Regev A, Buenrostro JD, Cunha TM, Chiu IM, Fisher DE, Hsu YC
published in: Nature
information resource reference: Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020 01; 577(7792):676-681.
journal title abbreviation: Nature
publication date: 2020-01-22T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1229991
type: Authorship
author rank in publication: 7
linked author: Chiu, Isaac
linked information resource: Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle.

Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle.
PubMed Identifier: 32102913
author list: Wang K, Yaghi OK, Spallanzani RG, Chen X, Zemmour D, Lai N, Chiu IM, Benoist C, Mathis D
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle. Proc Natl Acad Sci U S A. 2020 03 10; 117(10):5402-5408.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2020-02-26T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1234360
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: Neuro-immune Interactions in the Tissues.

Neuro-immune Interactions in the Tissues.
PubMed Identifier: 32187517
author list: Chu C, Artis D, Chiu IM
published in: Immunity
information resource reference: Neuro-immune Interactions in the Tissues. Immunity. 2020 03 17; 52(3):464-474.
journal title abbreviation: Immunity
publication date: 2020-03-17T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1257242
type: Authorship
author rank in publication: 1
linked author: Chiu, Isaac
linked information resource: Editorial overview: Brain, gut and immune system interactions.

Editorial overview: Brain, gut and immune system interactions.
PubMed Identifier: 32507295
author list: Chiu I, Rolls A
published in: Current opinion in neurobiology
information resource reference: Editorial overview: Brain, gut and immune system interactions. Curr Opin Neurobiol. 2020 06; 62:iii-v.
journal title abbreviation: Curr Opin Neurobiol
publication date: 2020-06-01T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1296326
type: Authorship
author rank in publication: 19
linked author: Chiu, Isaac
linked information resource: Transcriptional and proteomic insights into the host response in fatal COVID-19 cases.

Transcriptional and proteomic insights into the host response in fatal COVID-19 cases.
PubMed Identifier: 33082228
author list: Wu M, Chen Y, Xia H, Wang C, Tan CY, Cai X, Liu Y, Ji F, Xiong P, Liu R, Guan Y, Duan Y, Kuang D, Xu S, Cai H, Xia Q, Yang D, Wang MW, Chiu IM, Cheng C, Ahern PP, Liu L, Wang G, Surana NK, Xia T, Kasper DL
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Transcriptional and proteomic insights into the host response in fatal COVID-19 cases. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28336-28343.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2020-10-20T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1298816
type: Authorship
author rank in publication: 9
linked author: Chiu, Isaac
linked information resource: Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens.

Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens.
PubMed Identifier: 33098765
author list: Perner C, Flayer CH, Zhu X, Aderhold PA, Dewan ZNA, Voisin T, Camire RB, Chow OA, Chiu IM, Sokol CL
published in: Immunity
information resource reference: Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens. Immunity. 2020 11 17; 53(5):1063-1077.e7.
journal title abbreviation: Immunity
publication date: 2020-10-23T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1316456
type: Authorship
author rank in publication: 16
linked author: Chiu, Isaac
linked information resource: Gut-licensed IFN?+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes.

Authorship 1315946
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: Mechanisms of microbial-neuronal interactions in pain and nociception.

Mechanisms of microbial-neuronal interactions in pain and nociception.
PubMed Identifier: 33392418
author list: Lagomarsino VN, Kostic AD, Chiu IM
published in: Neurobiology of pain (Cambridge, Mass.)
information resource reference: Mechanisms of microbial-neuronal interactions in pain and nociception. Neurobiol Pain. 2021 Jan-Jul; 9:100056.
journal title abbreviation: Neurobiol Pain
publication date: 2020-12-11T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Gut-licensed IFN?+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes.
PubMed Identifier: 33408417
author list: Sanmarco LM, Wheeler MA, Gutiérrez-Vázquez C, Polonio CM, Linnerbauer M, Pinho-Ribeiro FA, Li Z, Giovannoni F, Batterman KV, Scalisi G, Zandee SEJ, Heck ES, Alsuwailm M, Rosene DL, Becher B, Chiu IM, Prat A, Quintana FJ
published in: Nature
information resource reference: Gut-licensed IFN?+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes. Nature. 2021 02; 590(7846):473-479.
journal title abbreviation: Nature
publication date: 2021-01-06T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Nociceptor neuron regulation of gastrointestinal barrier protection and host defense
end date: 2024-11-30
principal investigator name: CHIU, ISAAC MING-CHENG
start date: 2021-01-01
type: Grant
sponsor award id: R01DK127257

Principal Investigator
type: Researcher Role
researcher role of: Chiu, Isaac
contributes to: Nociceptor neuron regulation of gastrointestinal barrier protection and host defense

Authorship 1325167
type: Authorship
author rank in publication: 4
linked author: Chiu, Isaac
linked information resource: The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes.

The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes.
PubMed Identifier: 33542493
author list: Jacobson A, Yang D, Vella M, Chiu IM
published in: Mucosal immunology
information resource reference: The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes. Mucosal Immunol. 2021 05; 14(3):555-565.
journal title abbreviation: Mucosal Immunol
publication date: 2021-02-04T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1337259
type: Authorship
author rank in publication: 10
linked author: Chiu, Isaac
linked information resource: Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut.

Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut.
PubMed Identifier: 33691135
author list: Yan Y, Ramanan D, Rozenberg M, McGovern K, Rastelli D, Vijaykumar B, Yaghi O, Voisin T, Mosaheb M, Chiu I, Itzkovitz S, Rao M, Mathis D, Benoist C
published in: Immunity
information resource reference: Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut. Immunity. 2021 03 09; 54(3):499-513.e5.
journal title abbreviation: Immunity
publication date: 2021-03-09T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1342462
type: Authorship
author rank in publication: 11
linked author: Chiu, Isaac
linked information resource: The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch.

The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch.
PubMed Identifier: 33753496
author list: Voisin T, Perner C, Messou MA, Shiers S, Ualiyeva S, Kanaoka Y, Price TJ, Sokol CL, Bankova LG, Austen KF, Chiu IM
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch. Proc Natl Acad Sci U S A. 2021 03 30; 118(13).
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2021-03-30T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1343201
type: Authorship
author rank in publication: 2
linked author: Chiu, Isaac
linked information resource: Microbes and pain.

Microbes and pain.
PubMed Identifier: 33793668
author list: Deng L, Chiu IM
published in: PLoS pathogens
information resource reference: Microbes and pain. PLoS Pathog. 2021 04; 17(4):e1009398.
journal title abbreviation: PLoS Pathog
publication date: 2021-04-01T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1353543
type: Authorship
author rank in publication: 10
linked author: Chiu, Isaac
linked information resource: Pseudomonas aeruginosa-induced nociceptor activation increases susceptibility to infection.

Pseudomonas aeruginosa-induced nociceptor activation increases susceptibility to infection.
PubMed Identifier: 33956874
author list: Lin T, Quellier D, Lamb J, Voisin T, Baral P, Bock F, Schönberg A, Mirchev R, Pier G, Chiu I, Gadjeva M
published in: PLoS pathogens
information resource reference: Pseudomonas aeruginosa-induced nociceptor activation increases susceptibility to infection. PLoS Pathog. 2021 05; 17(5):e1009557.
journal title abbreviation: PLoS Pathog
publication date: 2021-05-06T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1385892
type: Authorship
author rank in publication: 8
linked author: Chiu, Isaac
linked information resource: Nociceptive Sensory Neurons Mediate Inflammation Induced by Bacillus Anthracis Edema Toxin.

Nociceptive Sensory Neurons Mediate Inflammation Induced by Bacillus Anthracis Edema Toxin.
PubMed Identifier: 34413846
author list: Yang NJ, Neel DV, Deng L, Heyang M, Kennedy-Curran A, Tong VS, Park JM, Chiu IM
published in: Frontiers in immunology
information resource reference: Nociceptive Sensory Neurons Mediate Inflammation Induced by Bacillus Anthracis Edema Toxin. Front Immunol. 2021; 12:642373.
journal title abbreviation: Front Immunol
publication date: 2021-08-03T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Gunner, Georgia
eCommons Login: geg769
first name: Georgia
last name: Gunner
full name: Georgia Gunner, Ph.D.
has faculty rank: Fellow or Post Doc
Person ID: 200936
person in primary position: Research Fellow in Immunology
type: Agent
type: Person
preferred title: Research Fellow in Immunology

Authorship 1419744
type: Authorship
author rank in publication: 30
linked author: Chiu, Isaac
linked information resource: Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons.

Authorship 1420398
type: Authorship
author rank in publication: 16
linked author: Chiu, Isaac
linked information resource: VLDLR and ApoER2 are receptors for multiple alphaviruses.

VLDLR and ApoER2 are receptors for multiple alphaviruses.
PubMed Identifier: 34929721
author list: Clark LE, Clark SA, Lin C, Liu J, Coscia A, Nabel KG, Yang P, Neel DV, Lee H, Brusic V, Stryapunina I, Plante KS, Ahmed AA, Catteruccia F, Young-Pearse TL, Chiu IM, Llopis PM, Weaver SC, Abraham J
published in: Nature
information resource reference: VLDLR and ApoER2 are receptors for multiple alphaviruses. Nature. 2022 02; 602(7897):475-480.
journal title abbreviation: Nature
publication date: 2021-12-20T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons.
PubMed Identifier: 34931070
author list: Yang NJ, Isensee J, Neel DV, Quadros AU, Zhang HB, Lauzadis J, Liu SM, Shiers S, Belu A, Palan S, Marlin S, Maignel J, Kennedy-Curran A, Tong VS, Moayeri M, Röderer P, Nitzsche A, Lu M, Pentelute BL, Brüstle O, Tripathi V, Foster KA, Price TJ, Collier RJ, Leppla SH, Puopolo M, Bean BP, Cunha TM, Hucho T, Chiu IM
published in: Nature neuroscience
information resource reference: Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons. Nat Neurosci. 2022 02; 25(2):168-179.
journal title abbreviation: Nat Neurosci
publication date: 2021-12-20T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1423317
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: Enteric glial cells mediate gut immunity and repair.

Authorship 1423578
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: Somatosensory and autonomic neuronal regulation of the immune response.

Enteric glial cells mediate gut immunity and repair.
PubMed Identifier: 34973845
author list: Wallrapp A, Yang D, Chiu IM
published in: Trends in neurosciences
information resource reference: Enteric glial cells mediate gut immunity and repair. Trends Neurosci. 2022 04; 45(4):251-253.
journal title abbreviation: Trends Neurosci
publication date: 2021-12-29T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Somatosensory and autonomic neuronal regulation of the immune response.
PubMed Identifier: 34997214
author list: Udit S, Blake K, Chiu IM
published in: Nature reviews. Neuroscience
information resource reference: Somatosensory and autonomic neuronal regulation of the immune response. Nat Rev Neurosci. 2022 03; 23(3):157-171.
journal title abbreviation: Nat Rev Neurosci
publication date: 2022-01-07T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1449111
type: Authorship
author rank in publication: 2
linked author: Chiu, Isaac
linked information resource: A neuropeptide regulates immunity across species.

Authorship 1447374
type: Authorship
author rank in publication: 4
linked author: Chiu, Isaac
linked information resource: Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis.

Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis.
PubMed Identifier: 35524757
author list: Neel DV, Basu H, Gunner G, Chiu IM
published in: Immunological reviews
information resource reference: Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis. Immunol Rev. 2022 10; 311(1):130-150.
journal title abbreviation: Immunol Rev
publication date: 2022-05-07T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

A neuropeptide regulates immunity across species.
PubMed Identifier: 35447095
author list: Deng L, Chiu IM
published in: Neuron
information resource reference: A neuropeptide regulates immunity across species. Neuron. 2022 04 20; 110(8):1275-1277.
journal title abbreviation: Neuron
publication date: 2022-04-20T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1468105
type: Authorship
author rank in publication: 1
linked author: Chiu, Isaac
linked information resource: Editorial overview: Special section neuroimmunology: Neuroimmune interactions in health and disease.

Editorial overview: Special section neuroimmunology: Neuroimmune interactions in health and disease.
PubMed Identifier: 35792467
author list: Chiu IM, Liblau R
published in: Current opinion in immunology
information resource reference: Editorial overview: Special section neuroimmunology: Neuroimmune interactions in health and disease. Curr Opin Immunol. 2022 08; 77:102232.
journal title abbreviation: Curr Opin Immunol
publication date: 2022-07-02T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1485932
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: Neuroimmune Interactions in Peripheral Organs.

Authorship 1499083
type: Authorship
author rank in publication: 25
linked author: Chiu, Isaac
linked information resource: Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection.

Authorship 1476990
type: Authorship
author rank in publication: 17
linked author: Chiu, Isaac
linked information resource: Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systems.

Authorship 1500059
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: Interactions between nociceptor sensory neurons and microbial pathogens in pain.

Neuroimmune Interactions in Peripheral Organs.
PubMed Identifier: 35363534
author list: Klein Wolterink RGJ, Wu GS, Chiu IM, Veiga-Fernandes H
published in: Annual review of neuroscience
information resource reference: Neuroimmune Interactions in Peripheral Organs. Annu Rev Neurosci. 2022 07 08; 45:339-360.
journal title abbreviation: Annu Rev Neurosci
publication date: 2022-04-01T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systems.
PubMed Identifier: 35643078
author list: Chen X, Ravindra Kumar S, Adams CD, Yang D, Wang T, Wolfe DA, Arokiaraj CM, Ngo V, Campos LJ, Griffiths JA, Ichiki T, Mazmanian SK, Osborne PB, Keast JR, Miller CT, Fox AS, Chiu IM, Gradinaru V
published in: Neuron
information resource reference: Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systems. Neuron. 2022 07 20; 110(14):2242-2257.e6.
journal title abbreviation: Neuron
publication date: 2022-05-27T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection.
PubMed Identifier: 36243004
author list: Yang D, Jacobson A, Meerschaert KA, Sifakis JJ, Wu M, Chen X, Yang T, Zhou Y, Anekal PV, Rucker RA, Sharma D, Sontheimer-Phelps A, Wu GS, Deng L, Anderson MD, Choi S, Neel D, Lee N, Kasper DL, Jabri B, Huh JR, Johansson M, Thiagarajah JR, Riesenfeld SJ, Chiu IM
published in: Cell
information resource reference: Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection. Cell. 2022 10 27; 185(22):4190-4205.e25.
journal title abbreviation: Cell
publication date: 2022-10-14T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Interactions between nociceptor sensory neurons and microbial pathogens in pain.
PubMed Identifier: 36252233
author list: Staurengo-Ferrari L, Deng L, Chiu IM
published in: Pain
information resource reference: Interactions between nociceptor sensory neurons and microbial pathogens in pain. Pain. 2022 11 01; 163(Suppl 1):S57-S68.
journal title abbreviation: Pain
publication date: 2022-11-01T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1515709
type: Authorship
author rank in publication: 19
linked author: Chiu, Isaac
linked information resource: Immunity to the microbiota promotes sensory neuron regeneration.

Immunity to the microbiota promotes sensory neuron regeneration.
PubMed Identifier: 36640762
author list: Enamorado M, Kulalert W, Han SJ, Rao I, Delaleu J, Link VM, Yong D, Smelkinson M, Gil L, Nakajima S, Linehan JL, Bouladoux N, Wlaschin J, Kabat J, Kamenyeva O, Deng L, Gribonika I, Chesler AT, Chiu IM, Le Pichon CE, Belkaid Y
published in: Cell
information resource reference: Immunity to the microbiota promotes sensory neuron regeneration. Cell. 2023 02 02; 186(3):607-620.e17.
journal title abbreviation: Cell
publication date: 2023-01-13T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1523658
type: Authorship
author rank in publication: 19
linked author: Chiu, Isaac
linked information resource: Microbiome induced complement synthesized in the gut protects against enteric infections.

Microbiome induced complement synthesized in the gut protects against enteric infections.
PubMed Identifier: 36778396
author list: Wu M, Zheng W, Song X, Bao B, Wang Y, Ramanan D, Yang D, Liu R, Macbeth JC, Do EA, Andrade WA, Yang T, Cho HS, Gazzaniga FS, Ilves M, Coronado D, Thompson C, Hang S, Chiu IM, Moffitt JR, Hsiao A, Mekalanos JJ, Benoist C, Kasper DL
published in: bioRxiv : the preprint server for biology
information resource reference: Microbiome induced complement synthesized in the gut protects against enteric infections. bioRxiv. 2023 Feb 03.
journal title abbreviation: bioRxiv
publication date: 2023-02-03T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1528208
type: Authorship
author rank in publication: 15
linked author: Chiu, Isaac
linked information resource: Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion.

Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion.
PubMed Identifier: 36859544
author list: Pinho-Ribeiro FA, Deng L, Neel DV, Erdogan O, Basu H, Yang D, Choi S, Walker AJ, Carneiro-Nascimento S, He K, Wu G, Stevens B, Doran KS, Levy D, Chiu IM
published in: Nature
information resource reference: Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion. Nature. 2023 03; 615(7952):472-481.
journal title abbreviation: Nature
publication date: 2023-03-01T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1530831
type: Authorship
author rank in publication: 23
linked author: Chiu, Isaac
linked information resource: Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration.

Authorship 1530388
type: Authorship
author rank in publication: 5
linked author: Chiu, Isaac
linked information resource: An airway-to-brain sensory pathway mediates influenza-induced sickness.

An airway-to-brain sensory pathway mediates influenza-induced sickness.
PubMed Identifier: 36890237
author list: Bin NR, Prescott SL, Horio N, Wang Y, Chiu IM, Liberles SD
published in: Nature
information resource reference: An airway-to-brain sensory pathway mediates influenza-induced sickness. Nature. 2023 03; 615(7953):660-667.
journal title abbreviation: Nature
publication date: 2023-03-08T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration.
PubMed Identifier: 36917977
author list: Neel DV, Basu H, Gunner G, Bergstresser MD, Giadone RM, Chung H, Miao R, Chou V, Brody E, Jiang X, Lee E, Watts ME, Marques C, Held A, Wainger B, Lagier-Tourenne C, Zhang YJ, Petrucelli L, Young-Pearse TL, Chen-Plotkin AS, Rubin LL, Lieberman J, Chiu IM
published in: Neuron
information resource reference: Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration. Neuron. 2023 04 19; 111(8):1222-1240.e9.
journal title abbreviation: Neuron
publication date: 2023-03-13T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1561839
type: Authorship
author rank in publication: 8
linked author: Chiu, Isaac
linked information resource: On-person adaptive evolution of Staphylococcus aureus during treatment for atopic dermatitis.

Authorship 1554710
type: Authorship
author rank in publication: 10
linked author: Chiu, Isaac
linked information resource: A DRG genetic toolkit reveals molecular, morphological, and functional diversity of somatosensory neuron subtypes.

Authorship 1572077
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: The role of cellular and molecular neuroimmune crosstalk in gut immunity.

On-person adaptive evolution of Staphylococcus aureus during treatment for atopic dermatitis.
PubMed Identifier: 37054679
author list: Key FM, Khadka VD, Romo-González C, Blake KJ, Deng L, Lynn TC, Lee JC, Chiu IM, García-Romero MT, Lieberman TD
published in: Cell host & microbe
information resource reference: On-person adaptive evolution of Staphylococcus aureus during treatment for atopic dermatitis. Cell Host Microbe. 2023 04 12; 31(4):593-603.e7.
journal title abbreviation: Cell Host Microbe
publication date: 2023-04-12T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

The role of cellular and molecular neuroimmune crosstalk in gut immunity.
PubMed Identifier: 37336989
author list: Yang D, Almanzar N, Chiu IM
published in: Cellular & molecular immunology
information resource reference: The role of cellular and molecular neuroimmune crosstalk in gut immunity. Cell Mol Immunol. 2023 11; 20(11):1259-1269.
journal title abbreviation: Cell Mol Immunol
publication date: 2023-06-19T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

A DRG genetic toolkit reveals molecular, morphological, and functional diversity of somatosensory neuron subtypes.
PubMed Identifier: 37131664
author list: Qi L, Iskols M, Shi D, Reddy P, Walker C, Lezgiyeva K, Voisin T, Pawlak M, Kuchroo VK, Chiu I, Ginty DD, Sharma N
published in: bioRxiv : the preprint server for biology
information resource reference: A DRG genetic toolkit reveals molecular, morphological, and functional diversity of somatosensory neuron subtypes. bioRxiv. 2023 Apr 23.
journal title abbreviation: bioRxiv
publication date: 2023-04-23T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1585137
type: Authorship
author rank in publication: 14
linked author: Chiu, Isaac
linked information resource: A collaboration between immune cells and the choroid plexus epithelium in brain inflammation.

Authorship 1590351
type: Authorship
author rank in publication: 6
linked author: Chiu, Isaac
linked information resource: Lipopolysaccharide-Induced TRPA1 Upregulation in Trigeminal Neurons is Dependent on TLR4 and Vesicular Exocytosis.

Authorship 1592004
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: Dynamics of Innate Immune Response in Bacteria-Induced Mouse Model of Pulpitis.

A collaboration between immune cells and the choroid plexus epithelium in brain inflammation.
PubMed Identifier: 37609192
author list: Xu H, Lotfy P, Gelb S, Pragana A, Hehnly C, Shipley FB, Zawadzki ME, Cui J, Deng L, Taylor M, Webb M, Lidov HGW, Andermann ML, Chiu IM, Ordovas-Montanes J, Lehtinen MK
published in: bioRxiv : the preprint server for biology
information resource reference: A collaboration between immune cells and the choroid plexus epithelium in brain inflammation. bioRxiv. 2023 Aug 08.
journal title abbreviation: bioRxiv
publication date: 2023-08-08T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Lipopolysaccharide-Induced TRPA1 Upregulation in Trigeminal Neurons is Dependent on TLR4 and Vesicular Exocytosis.
PubMed Identifier: 37643860
author list: Michot B, Casey SM, Lee CS, Erdogan O, Basu H, Chiu I, Gibbs JL
published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
information resource reference: Lipopolysaccharide-Induced TRPA1 Upregulation in Trigeminal Neurons is Dependent on TLR4 and Vesicular Exocytosis. J Neurosci. 2023 10 04; 43(40):6731-6744.
journal title abbreviation: J Neurosci
publication date: 2023-08-29T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Dynamics of Innate Immune Response in Bacteria-Induced Mouse Model of Pulpitis.
PubMed Identifier: 37678750
author list: Erdogan O, Xia J, Chiu IM, Gibbs JL
published in: Journal of endodontics
information resource reference: Dynamics of Innate Immune Response in Bacteria-Induced Mouse Model of Pulpitis. J Endod. 2023 11; 49(11):1529-1536.
journal title abbreviation: J Endod
publication date: 2023-09-09T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Research Fellow in Immunology
is primary position: true
position in department: Immunology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Research Fellow in Immunology
position in organization: Harvard Medical School

Authorship 1598756
type: Authorship
author rank in publication: 7
linked author: Chiu, Isaac
linked information resource: Neuronal-immune axis alters pain and sensory afferent damage during dental pulp injury.

Neuronal-immune axis alters pain and sensory afferent damage during dental pulp injury.
PubMed Identifier: 37903298
author list: Erdogan O, Michot B, Xia J, Alabdulaaly L, Yesares Rubi P, Ha V, Chiu IM, Gibbs JL
published in: Pain
information resource reference: Neuronal-immune axis alters pain and sensory afferent damage during dental pulp injury. Pain. 2024 Feb 01; 165(2):392-403.
journal title abbreviation: Pain
publication date: 2023-10-30T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis.
PubMed Identifier: 37995657
author list: Deng L, Costa F, Blake KJ, Choi S, Chandrabalan A, Yousuf MS, Shiers S, Dubreuil D, Vega-Mendoza D, Rolland C, Deraison C, Voisin T, Bagood MD, Wesemann L, Frey AM, Palumbo JS, Wainger BJ, Gallo RL, Leyva-Castillo JM, Vergnolle N, Price TJ, Ramachandran R, Horswill AR, Chiu IM
published in: Cell
information resource reference: S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis. Cell. 2023 11 22; 186(24):5375-5393.e25.
journal title abbreviation: Cell
publication date: 2023-11-22T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1610783
type: Authorship
author rank in publication: 24
linked author: Chiu, Isaac
linked information resource: S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis.

Authorship 1621667
type: Authorship
author rank in publication: 11
linked author: Chiu, Isaac
linked information resource: The neuroimmune CGRP-RAMP1 axis tunes cutaneous adaptive immunity to the microbiota.

The neuroimmune CGRP-RAMP1 axis tunes cutaneous adaptive immunity to the microbiota.
PubMed Identifier: 38234748
author list: Kulalert W, Wells AC, Link VM, Lim AI, Bouladoux N, Nagai M, Harrison OJ, Kamenyeva O, Kabat J, Enamorado M, Chiu IM, Belkaid Y
published in: bioRxiv : the preprint server for biology
information resource reference: The neuroimmune CGRP-RAMP1 axis tunes cutaneous adaptive immunity to the microbiota. bioRxiv. 2023 Dec 26.
journal title abbreviation: bioRxiv
publication date: 2023-12-26T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Gut complement induced by the microbiota combats pathogens and spares commensals.
PubMed Identifier: 38280374
author list: Wu M, Zheng W, Song X, Bao B, Wang Y, Ramanan D, Yang D, Liu R, Macbeth JC, Do EA, Andrade WA, Yang T, Cho HS, Gazzaniga FS, Ilves M, Coronado D, Thompson C, Hang S, Chiu IM, Moffitt JR, Hsiao A, Mekalanos JJ, Benoist C, Kasper DL
published in: Cell
information resource reference: Gut complement induced by the microbiota combats pathogens and spares commensals. Cell. 2024 Feb 15; 187(4):897-913.e18.
journal title abbreviation: Cell
publication date: 2024-01-26T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1625729
type: Authorship
author rank in publication: 19
linked author: Chiu, Isaac
linked information resource: Gut complement induced by the microbiota combats pathogens and spares commensals.

Authorship 1628360
type: Authorship
author rank in publication: 8
linked author: Chiu, Isaac
linked information resource: Basophils are important for development of allergic skin inflammation.

Basophils are important for development of allergic skin inflammation.
PubMed Identifier: 38336257
author list: Leyva-Castillo JM, Vega-Mendoza D, Strakosha M, Deng L, Choi S, Miyake K, Karasuyama H, Chiu IM, Phipatanakul W, Geha RS
published in: The Journal of allergy and clinical immunology
information resource reference: Basophils are important for development of allergic skin inflammation. J Allergy Clin Immunol. 2024 May; 153(5):1344-1354.e5.
journal title abbreviation: J Allergy Clin Immunol
publication date: 2024-02-07T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1634829
type: Authorship
author rank in publication: 11
linked author: Chiu, Isaac
linked information resource: The neuroimmune CGRP-RAMP1 axis tunes cutaneous adaptive immunity to the microbiota.

Authorship 1634496
type: Authorship
author rank in publication: 10
linked author: Chiu, Isaac
linked information resource: A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes.

A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes.
PubMed Identifier: 38442711
author list: Qi L, Iskols M, Shi D, Reddy P, Walker C, Lezgiyeva K, Voisin T, Pawlak M, Kuchroo VK, Chiu IM, Ginty DD, Sharma N
published in: Cell
information resource reference: A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes. Cell. 2024 Mar 14; 187(6):1508-1526.e16.
journal title abbreviation: Cell
publication date: 2024-03-04T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

The neuroimmune CGRP-RAMP1 axis tunes cutaneous adaptive immunity to the microbiota.
PubMed Identifier: 38451947
author list: Kulalert W, Wells AC, Link VM, Lim AI, Bouladoux N, Nagai M, Harrison OJ, Kamenyeva O, Kabat J, Enamorado M, Chiu IM, Belkaid Y
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: The neuroimmune CGRP-RAMP1 axis tunes cutaneous adaptive immunity to the microbiota. Proc Natl Acad Sci U S A. 2024 Mar 12; 121(11):e2322574121.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2024-03-07T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1636209
type: Authorship
author rank in publication: 7
linked author: Chiu, Isaac
linked information resource: 2023 Workshop: Neuroimmune Crosstalk in the Gut - Impact on Local, Autonomic and Gut-Brain Function.

2023 Workshop: Neuroimmune Crosstalk in the Gut - Impact on Local, Autonomic and Gut-Brain Function.
PubMed Identifier: 38518873
author list: Margolis KG, Shea-Donohue T, Cummings DM, Greenwel P, Lunsford RD, Gulbransen BD, Chiu IM
published in: Gastroenterology
information resource reference: 2023 Workshop: Neuroimmune Crosstalk in the Gut - Impact on Local, Autonomic and Gut-Brain Function. Gastroenterology. 2024 Jul; 167(2):223-230.
journal title abbreviation: Gastroenterology
publication date: 2024-03-21T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1641339
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: Sensory neurons: An integrated component of innate immunity.

Sensory neurons: An integrated component of innate immunity.
PubMed Identifier: 38599172
author list: Deng L, Gillis JE, Chiu IM, Kaplan DH
published in: Immunity
information resource reference: Sensory neurons: An integrated component of innate immunity. Immunity. 2024 04 09; 57(4):815-831.
journal title abbreviation: Immunity
publication date: 2024-04-09T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Staphylococcus aureus induced itch and neuro-immune signaling in skin infections
end date: 2027-07-31
principal investigator name: CHIU, ISAAC MING-CHENG
start date: 2022-09-19
type: Grant
sponsor award id: R01AI168005

Principal Investigator
type: Researcher Role
researcher role of: Chiu, Isaac
contributes to: Staphylococcus aureus induced itch and neuro-immune signaling in skin infections

Authorship 1648889
type: Authorship
author rank in publication: 19
linked author: Chiu, Isaac
linked information resource: Induction of antiviral interferon-stimulated genes by neuronal STING promotes the resolution of pain in mice.

Induction of antiviral interferon-stimulated genes by neuronal STING promotes the resolution of pain in mice.
PubMed Identifier: 38690737
author list: Defaye M, Bradaia A, Abdullah NS, Agosti F, Iftinca M, Delanne-Cuménal M, Soubeyre V, Svendsen K, Gill G, Ozmaeian A, Gheziel N, Martin J, Poulen G, Lonjon N, Vachiery-Lahaye F, Bauchet L, Basso L, Bourinet E, Chiu IM, Altier C
published in: The Journal of clinical investigation
information resource reference: Induction of antiviral interferon-stimulated genes by neuronal STING promotes the resolution of pain in mice. J Clin Invest. 2024 Mar 19; 134(9).
journal title abbreviation: J Clin Invest
publication date: 2024-03-19T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1658721
type: Authorship
author rank in publication: 2
linked author: Chiu, Isaac
linked information resource: Neuroimmune Interactions in the Intestine.

Neuroimmune Interactions in the Intestine.
PubMed Identifier: 38941607
author list: Wallrapp A, Chiu IM
published in: Annual review of immunology
information resource reference: Neuroimmune Interactions in the Intestine. Annu Rev Immunol. 2024 06; 42(1):489-519.
journal title abbreviation: Annu Rev Immunol
publication date: 2024-06-01T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1663678
type: Authorship
author rank in publication: 8
linked author: Chiu, Isaac
linked information resource: The meninges host a unique compartment of regulatory T cells that bulwarks adult hippocampal neurogenesis.

The meninges host a unique compartment of regulatory T cells that bulwarks adult hippocampal neurogenesis.
PubMed Identifier: 38948783
author list: Marin-Rodero M, Reyes EC, Walker AJ, Jayewickreme T, Pinho-Ribeiro FA, Richardson Q, Jackson R, Chiu IM, Benoist C, Stevens B, Trejo JL, Mathis D
published in: bioRxiv : the preprint server for biology
information resource reference: The meninges host a unique compartment of regulatory T cells that bulwarks adult hippocampal neurogenesis. bioRxiv. 2024 Jun 17.
journal title abbreviation: bioRxiv
publication date: 2024-06-17T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1669293
type: Authorship
author rank in publication: 15
linked author: Chiu, Isaac
linked information resource: The choroid plexus synergizes with immune cells during neuroinflammation.

Authorship 1669256
type: Authorship
author rank in publication: 12
linked author: Chiu, Isaac
linked information resource: A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut.

Authorship 1669852
type: Authorship
author rank in publication: 26
linked author: Chiu, Isaac
linked information resource: Shifts in receptors during submergence of an encephalitic arbovirus.

A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut.
PubMed Identifier: 39088603
author list: Zhu Y, Meerschaert KA, Galvan-Pena S, Bin NR, Yang D, Basu H, Kawamoto R, Shalaby A, Liberles SD, Mathis D, Benoist C, Chiu IM
published in: Science (New York, N.Y.)
information resource reference: A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut. Science. 2024 08 02; 385(6708):eadk1679.
journal title abbreviation: Science
publication date: 2024-08-02T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

The choroid plexus synergizes with immune cells during neuroinflammation.
PubMed Identifier: 39089253
author list: Xu H, Lotfy P, Gelb S, Pragana A, Hehnly C, Byer LIJ, Shipley FB, Zawadzki ME, Cui J, Deng L, Taylor M, Webb M, Lidov HGW, Andermann ML, Chiu IM, Ordovas-Montanes J, Lehtinen MK
published in: Cell
information resource reference: The choroid plexus synergizes with immune cells during neuroinflammation. Cell. 2024 Sep 05; 187(18):4946-4963.e17.
journal title abbreviation: Cell
publication date: 2024-07-31T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Shifts in receptors during submergence of an encephalitic arbovirus.
PubMed Identifier: 39048821
author list: Li W, Plante JA, Lin C, Basu H, Plung JS, Fan X, Boeckers JM, Oros J, Buck TK, Anekal PV, Hanson WA, Varnum H, Wells A, Mann CJ, Tjang LV, Yang P, Reyna RA, Mitchell BM, Shinde DP, Walker JL, Choi SY, Brusic V, Llopis PM, Weaver SC, Umemori H, Chiu IM, Plante KS, Abraham J
published in: Nature
information resource reference: Shifts in receptors during submergence of an encephalitic arbovirus. Nature. 2024 08; 632(8025):614-621.
journal title abbreviation: Nature
publication date: 2024-07-24T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Research Fellow in Immunology
is primary position: true
position in department: Immunology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Research Fellow in Immunology
position in organization: Harvard Medical School

Assistant Professor of Medicine
is primary position: true
position in department: Medicine
position in division: Allergy/Immunology
sort order: 1
type: Position
HR job title: Assistant Professor of Medicine
position in organization: Massachusetts General Hospital

Kurt J. Isselbacher Professor of Medicine in the Field of Gastroenterology
is primary position: true
position in department: Medicine
position in division: Gastroenterology
sort order: 1
type: Position
HR job title: Kurt J. Isselbacher Professor of Medicine in the Field of Gastroenterology
position in organization: Massachusetts General Hospital

Authorship 1685554
type: Authorship
author rank in publication: 1
linked author: Chiu, Isaac
linked information resource: Neuroimmune recognition of allergens.

Authorship 1688837
type: Authorship
author rank in publication: 21
linked author: Chiu, Isaac
linked information resource: Vagal TRPV1 + sensory neurons regulate myeloid cell dynamics and protect against influenza virus infection.

Neuroimmune recognition of allergens.
PubMed Identifier: 39213825
author list: Chiu IM, Sokol CL
published in: Current opinion in immunology
information resource reference: Neuroimmune recognition of allergens. Curr Opin Immunol. 2024 Oct; 90:102458.
journal title abbreviation: Curr Opin Immunol
publication date: 2024-08-29T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Vagal TRPV1 + sensory neurons regulate myeloid cell dynamics and protect against influenza virus infection.
PubMed Identifier: 39229208
author list: Yang D, Almanzar N, Xia J, Udit S, Yeung ST, Khairallah C, Hoagland DA, Umans BD, Sarden N, Erdogan O, Baalbaki N, Beekmayer-Dhillon A, Lee J, Meerschaert KA, Liberles SD, Yipp BG, Franklin RA, Khanna KM, Baral P, Haber AL, Chiu IM
published in: bioRxiv : the preprint server for biology
information resource reference: Vagal TRPV1 + sensory neurons regulate myeloid cell dynamics and protect against influenza virus infection. bioRxiv. 2024 Aug 22.
journal title abbreviation: bioRxiv
publication date: 2024-08-22T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 650592
type: Authorship
author rank in publication: 1
linked author: Chiu, Isaac
linked information resource: A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model.

A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model.
PubMed Identifier: 23850290
author list: Chiu IM, Morimoto ET, Goodarzi H, Liao JT, O'Keeffe S, Phatnani HP, Muratet M, Carroll MC, Levy S, Tavazoie S, Myers RM, Maniatis T
published in: Cell reports
information resource reference: A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. Cell Rep. 2013 Jul 25; 4(2):385-401.
journal title abbreviation: Cell Rep
publication date: 2013-07-11T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1701776
type: Authorship
author rank in publication: 22
linked author: Chiu, Isaac
linked information resource: Neuropeptide signalling orchestrates T cell differentiation.

Authorship 1702155
type: Authorship
author rank in publication: 7
linked author: Chiu, Isaac
linked information resource: Gasdermin D is activated but does not drive neurodegeneration in SOD1 G93A model of ALS: Implications for targeting pyroptosis.

Neuropeptide signalling orchestrates T cell differentiation.
PubMed Identifier: 39415015
author list: Hou Y, Sun L, LaFleur MW, Huang L, Lambden C, Thakore PI, Geiger-Schuller K, Kimura K, Yan L, Zang Y, Tang R, Shi J, Barilla R, Deng L, Subramanian A, Wallrapp A, Choi HS, Kye YC, Ashenberg O, Schiebinger G, Doench JG, Chiu IM, Regev A, Sharpe AH, Kuchroo VK
published in: Nature
information resource reference: Neuropeptide signalling orchestrates T cell differentiation. Nature. 2024 11; 635(8038):444-452.
journal title abbreviation: Nature
publication date: 2024-10-16T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Gasdermin D is activated but does not drive neurodegeneration in SOD1 G93A model of ALS: Implications for targeting pyroptosis.
PubMed Identifier: 39416104
author list: Gunner G, Basu H, Lu Y, Bergstresser M, Neel D, Choi SY, Chiu IM
published in: bioRxiv : the preprint server for biology
information resource reference: Gasdermin D is activated but does not drive neurodegeneration in SOD1 G93A model of ALS: Implications for targeting pyroptosis. bioRxiv. 2024 Oct 12.
journal title abbreviation: bioRxiv
publication date: 2024-10-12T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Professor of Immunology
is primary position: true
position in department: Immunology
position in division: Immunology
sort order: 1
type: Position
HR job title: Professor of Immunology
position in organization: Harvard Medical School

Authorship 1708079
type: Authorship
author rank in publication: 2
linked author: Chiu, Isaac
linked information resource: The gut-brain axis and pain signalling mechanisms in the gastrointestinal tract.

The gut-brain axis and pain signalling mechanisms in the gastrointestinal tract.
PubMed Identifier: 39578592
author list: Meerschaert KA, Chiu IM
published in: Nature reviews. Gastroenterology & hepatology
information resource reference: The gut-brain axis and pain signalling mechanisms in the gastrointestinal tract. Nat Rev Gastroenterol Hepatol. 2025 Mar; 22(3):206-221.
journal title abbreviation: Nat Rev Gastroenterol Hepatol
publication date: 2024-11-22T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Immunology
type: Department
type: Organization

Authorship 671132
type: Authorship
author rank in publication: 2
linked author: Chiu, Isaac
linked information resource: The human natural killer cell immune synapse.

Authorship 671133
type: Authorship
author rank in publication: 1
linked author: Chiu, Isaac
linked information resource: Trafficking of spontaneously endocytosed MHC proteins.

Authorship 671134
type: Authorship
author rank in publication: 4
linked author: Chiu, Isaac
linked information resource: Impaired spontaneous endocytosis of HLA-G.

Authorship 671135
type: Authorship
author rank in publication: 1
linked author: Chiu, Isaac
linked information resource: Bacteria activate sensory neurons that modulate pain and inflammation.

Bacteria activate sensory neurons that modulate pain and inflammation.
PubMed Identifier: 23965627
author list: Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ
published in: Nature
information resource reference: Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 2013 Sep 05; 501(7465):52-7.
journal title abbreviation: Nature
publication date: 2013-08-21T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular basis for shifted receptor recognition by an encephalitic arbovirus.
PubMed Identifier: 39803583
author list: Fan X, Li W, Oros J, Plung JS, Plante JA, Basu H, Nagappan-Chettiar S, Boeckers JM, Tjang LV, Mann CJ, Brusic V, Buck TK, Varnum H, Yang P, Malcolm LM, Choi SY, de Souza WM, Chiu IM, Umemori H, Weaver SC, Plante KS, Abraham J
published in: bioRxiv : the preprint server for biology
information resource reference: Molecular basis for shifted receptor recognition by an encephalitic arbovirus. bioRxiv. 2025 Jan 02.
journal title abbreviation: bioRxiv
publication date: 2025-01-02T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1718483
type: Authorship
author rank in publication: 18
linked author: Chiu, Isaac
linked information resource: Molecular basis for shifted receptor recognition by an encephalitic arbovirus.

Authorship 1725106
type: Authorship
author rank in publication: 8
linked author: Chiu, Isaac
linked information resource: The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis.

The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis.
PubMed Identifier: 39873623
author list: Marin-Rodero M, Cintado E, Walker AJ, Jayewickreme T, Pinho-Ribeiro FA, Richardson Q, Jackson R, Chiu IM, Benoist C, Stevens B, Trejo JL, Mathis D
published in: Science immunology
information resource reference: The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis. Sci Immunol. 2025 02 28; 10(104):eadu2910.
journal title abbreviation: Sci Immunol
publication date: 2025-02-28T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1736710
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: Sensory neurons on guard: roles in pathogen defense and host immunity.

Sensory neurons on guard: roles in pathogen defense and host immunity.
PubMed Identifier: 40015178
author list: Erdogan O, Hu XQ, Chiu IM
published in: Current opinion in immunology
information resource reference: Sensory neurons on guard: roles in pathogen defense and host immunity. Curr Opin Immunol. 2025 Apr; 93:102541.
journal title abbreviation: Curr Opin Immunol
publication date: 2025-02-26T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 222067
type: Authorship
author rank in publication: 5
linked author: Chiu, Isaac
linked information resource: Suppression of complement regulatory protein C1 inhibitor in vascular endothelial activation by inhibiting vascular cell adhesion molecule-1 action.

Professor of Pediatrics, Emeritus
is primary position: true
position in department: Emeritus
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Pediatrics, Emeritus
position in organization: Harvard Medical School

Professor of Pediatrics and Medicine, Emeritus
is primary position: true
position in department: Emeritus
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Pediatrics and Medicine, Emeritus
position in organization: Harvard Medical School

Professor of Neurology, Emeritus
is primary position: true
position in department: Emeritus
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Neurology, Emeritus
position in organization: Harvard Medical School

Authorship 1739303
type: Authorship
author rank in publication: 19
linked author: Chiu, Isaac
linked information resource: Molecular basis for shifted receptor recognition by an encephalitic arbovirus.

Authorship 1742583
type: Authorship
author rank in publication: 22
linked author: Chiu, Isaac
linked information resource: Psychedelic control of neuroimmune interactions governing fear.

Authorship 1744107
type: Authorship
author rank in publication: 2
linked author: Chiu, Isaac
linked information resource: Neurotransmitter and neuropeptide regulation of gut immunity.

Authorship 1747826
type: Authorship
author rank in publication: 20
linked author: Chiu, Isaac
linked information resource: CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model.

Authorship 1747922
type: Authorship
author rank in publication: 17
linked author: Chiu, Isaac
linked information resource: Psychological stress increases skin infection through the action of TGFß to suppress immune-acting fibroblasts.

Neurotransmitter and neuropeptide regulation of gut immunity.
PubMed Identifier: 40311282
author list: Wong C, Chiu IM
published in: Current opinion in neurobiology
information resource reference: Neurotransmitter and neuropeptide regulation of gut immunity. Curr Opin Neurobiol. 2025 Jun; 92:103036.
journal title abbreviation: Curr Opin Neurobiol
publication date: 2025-04-30T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model.
PubMed Identifier: 40033124
author list: Kadowaki A, Wheeler MA, Li Z, Andersen BM, Lee HG, Illouz T, Lee JH, Ndayisaba A, Zandee SEJ, Basu H, Chao CC, Mahler JV, Klement W, Neel D, Bergstresser M, Rothhammer V, Lipof G, Srun L, Soleimanpour SA, Chiu I, Prat A, Khurana V, Quintana FJ
published in: Nature neuroscience
information resource reference: CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model. Nat Neurosci. 2025 Mar; 28(3):470-486.
journal title abbreviation: Nat Neurosci
publication date: 2025-03-03T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular basis for shifted receptor recognition by an encephalitic arbovirus.
PubMed Identifier: 40187345
author list: Fan X, Li W, Oros J, Plante JA, Mitchell BM, Plung JS, Basu H, Nagappan-Chettiar S, Boeckers JM, Tjang LV, Mann CJ, Brusic V, Buck TK, Varnum H, Yang P, Malcolm LM, Choi SY, de Souza WM, Chiu IM, Umemori H, Weaver SC, Plante KS, Abraham J
published in: Cell
information resource reference: Molecular basis for shifted receptor recognition by an encephalitic arbovirus. Cell. 2025 May 29; 188(11):2957-2973.e28.
journal title abbreviation: Cell
publication date: 2025-04-04T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Psychedelic control of neuroimmune interactions governing fear.
PubMed Identifier: 40269152
author list: Chung EN, Lee J, Polonio CM, Choi J, Akl CF, Kilian M, Weiß WM, Gunner G, Ye M, Heo TH, Drake SS, Yang L, d'Eca CRGL, Lee JH, Deng L, Farrenkopf D, Schüle AM, Lee HG, Afolabi O, Ghaznavi S, Smirnakis SM, Chiu IM, Kuchroo VK, Quintana FJ, Wheeler MA
published in: Nature
information resource reference: Psychedelic control of neuroimmune interactions governing fear. Nature. 2025 05; 641(8065):1276-1286.
journal title abbreviation: Nature
publication date: 2025-04-23T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Psychological stress increases skin infection through the action of TGFß to suppress immune-acting fibroblasts.
PubMed Identifier: 40215323
author list: Chan H, Li F, Dokoshi T, Cavagnero KJ, Li Q, Chen Y, Aguilera C, Nakatsuji T, Liu E, Indra A, Yang D, Valentina O, Numata T, Crown B, Li H, Williams KJ, Chiu IM, Bensinger SJ, Chen W, Gallo RL
published in: Science immunology
information resource reference: Psychological stress increases skin infection through the action of TGFß to suppress immune-acting fibroblasts. Sci Immunol. 2025 04 11; 10(106):eads0519.
journal title abbreviation: Sci Immunol
publication date: 2025-04-11T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Clinical Fellow in Medicine
is primary position: true
position in department: Medicine
position in division: Internal Medicine
sort order: 1
type: Position
HR job title: Clinical Fellow in Medicine
position in organization: Brigham and Women's Hospital

Gasdermin D is activated but does not drive neurodegeneration in SOD1G93A model of ALS: Implications for targeting pyroptosis.
PubMed Identifier: 40759286
author list: Gunner G, Basu H, Lu Y, Bergstresser M, Sun L, Neel D, Choi SY, Chiu IM
published in: Neurobiology of disease
information resource reference: Gasdermin D is activated but does not drive neurodegeneration in SOD1G93A model of ALS: Implications for targeting pyroptosis. Neurobiol Dis. 2025 10 01; 214:107048.
journal title abbreviation: Neurobiol Dis
publication date: 2025-08-06T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Marion V. Nelson Professor of Biomedical Informatics
is primary position: true
position in department: Biomedical Informatics
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Marion V. Nelson Professor of Biomedical Informatics
position in organization: Harvard Medical School

Authorship 1778245
type: Authorship
author rank in publication: 8
linked author: Chiu, Isaac
linked information resource: Gasdermin D is activated but does not drive neurodegeneration in SOD1G93A model of ALS: Implications for targeting pyroptosis.

Authorship 1791703
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: Neuronal VPS13D loss drives microglial activation.

Authorship 1800834
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: Microbiota-neuroimmune cross talk in stress-induced visceral hypersensitivity of the bowel.

Authorship 1827930
type: Authorship
author rank in publication: 36
linked author: Chiu, Isaac
linked information resource: Adrenergic signaling coordinates distant and local responses to amputation in axolotl.

Authorship 1849125
type: Authorship
author rank in publication: 13
linked author: Chiu, Isaac
linked information resource: Sensory neuropeptide CGRP and its co-receptor RAMP1 drive tumour cell growth in gastrointestinal cancers.

Authorship 1849507
type: Authorship
author rank in publication: 10
linked author: Chiu, Isaac
linked information resource: A myeloid Tet2-IL-1ß axis modulates intestinal inflammation by restricting catecholaminergic stimulation of enterochromaffin cell differentiation.

Microbiota-neuroimmune cross talk in stress-induced visceral hypersensitivity of the bowel.
PubMed Identifier: 32308040
author list: van Thiel IAM, de Jonge WJ, Chiu IM, van den Wijngaard RM
published in: American journal of physiology. Gastrointestinal and liver physiology
information resource reference: Microbiota-neuroimmune cross talk in stress-induced visceral hypersensitivity of the bowel. Am J Physiol Gastrointest Liver Physiol. 2020 06 01; 318(6):G1034-G1041.
journal title abbreviation: Am J Physiol Gastrointest Liver Physiol
publication date: 2020-04-20T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Adrenergic signaling coordinates distant and local responses to amputation in axolotl.
PubMed Identifier: 40777403
author list: Payzin-Dogru D, Froitzheim T, Blair SJ, Jena SG, Singer H, Paoli JC, Kim RT, Kriukov E, Wilson SE, Hou R, Savage AM, Cat V, Cammarata LV, Wu SYC, Bothe V, Erdogan B, Hossain S, Lopez N, Losner J, Matos JV, Min S, Böhm S, Striker AE, Dooling KE, Freedman AH, Groves B, Tajer B, Kalu G, Wynn E, Wong AYL, Fröbisch N, Baranov P, Plikus MV, Buenrostro JD, Haas BJ, Chiu IM, Sackton TB, Whited JL
published in: bioRxiv : the preprint server for biology
information resource reference: Adrenergic signaling coordinates distant and local responses to amputation in axolotl. bioRxiv. 2025 Jul 24.
journal title abbreviation: bioRxiv
publication date: 2025-07-24T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

A myeloid Tet2-IL-1ß axis modulates intestinal inflammation by restricting catecholaminergic stimulation of enterochromaffin cell differentiation.
PubMed Identifier: 41187762
author list: Sharma D, Malik A, Locher V, McGrath S, Zabala S, Grover H, Ciszewski C, Chen L, Yang D, Chiu IM, Jabri B
published in: Immunity
information resource reference: A myeloid Tet2-IL-1ß axis modulates intestinal inflammation by restricting catecholaminergic stimulation of enterochromaffin cell differentiation. Immunity. 2025 Nov 11; 58(11):2785-2798.e4.
journal title abbreviation: Immunity
publication date: 2025-11-03T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Neuronal VPS13D loss drives microglial activation.
PubMed Identifier: 40646308
author list: Basu H, Holliday C, Chiu IM
published in: Nature structural & molecular biology
information resource reference: Neuronal VPS13D loss drives microglial activation. Nat Struct Mol Biol. 2025 Oct; 32(10):1859-1861.
journal title abbreviation: Nat Struct Mol Biol
publication date: 2025-10-01T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

Sensory neuropeptide CGRP and its co-receptor RAMP1 drive tumour cell growth in gastrointestinal cancers.
PubMed Identifier: 41158750
author list: Parathan P, Tran K, Neil L, Tan T, Carli ALE, Liao Y, Mouradov D, Da Gama Duarte J, Huber A, Pal B, Gibbs P, Sieber OM, Chiu IM, Kearney CJ, Shi W, Mariadason JM, Williams DS, Buchert M, Mielke LA
published in: BMJ oncology
information resource reference: Sensory neuropeptide CGRP and its co-receptor RAMP1 drive tumour cell growth in gastrointestinal cancers. BMJ Oncol. 2025; 4(1):e000842.
journal title abbreviation: BMJ Oncol
publication date: 2025-10-24T00:00:00
year: 2025
type: Academic Article
type: Article
type: Document
type: Information Resource

John Hedley-Whyte Professor of Anaesthesia
is primary position: true
position in department: Anaesthesia
position in division: Translational Research
sort order: 1
type: Position
HR job title: John Hedley-Whyte Professor of Anaesthesia
position in organization: Beth Israel Deaconess Medical Center

Neuroimmunology
type: Division
type: Organization

Samuel L. Wasserstrom Professor of Neurology
is primary position: true
position in department: Neurology
position in division: Neuroimmunology
sort order: 1
type: Position
HR job title: Samuel L. Wasserstrom Professor of Neurology
position in organization: Brigham and Women's Hospital

Basu, Himanish
eCommons Login: HB76
first name: Himanish
last name: Basu
full name: Himanish Basu, Ph.D.
has faculty rank: Fellow or Post Doc
Person ID: 108942
person in primary position: Research Fellow in Immunology
type: Agent
type: Person
preferred title: Research Fellow in Immunology

Professor of Neurology
is primary position: true
position in department: Neurology
position in division: https://connects.catalyst.harvard.edu/Profiles/profile/1229413
sort order: 1
type: Position
HR job title: Professor of Neurology
position in organization: Boston Children's Hospital

Authorship 750112
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: L-Rhamnose-containing supramolecular nanofibrils as potential immunosuppressive materials.

L-Rhamnose-containing supramolecular nanofibrils as potential immunosuppressive materials.
PubMed Identifier: 25078446
author list: Zhao F, Heesters BA, Chiu I, Gao Y, Shi J, Zhou N, Carroll MC, Xu B
published in: Organic & biomolecular chemistry
information resource reference: L-Rhamnose-containing supramolecular nanofibrils as potential immunosuppressive materials. Org Biomol Chem. 2014 Sep 21; 12(35):6816-9.
journal title abbreviation: Org Biomol Chem
publication date: 2014-09-21T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 436041
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis.

Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.
PubMed Identifier: 25420066
author list: Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ
published in: Nature neuroscience
information resource reference: Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci. 2015 Jan; 18(1):17-24.
journal title abbreviation: Nat Neurosci
publication date: 2014-11-24T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 777073
type: Authorship
author rank in publication: 9
linked author: Chiu, Isaac
linked information resource: Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.

Authorship 777074
type: Authorship
author rank in publication: 1
linked author: Chiu, Isaac
linked information resource: Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity.

Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity.
PubMed Identifier: 25525749
author list: Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman GS, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf CJ
published in: eLife
information resource reference: Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity. Elife. 2014 Dec 19; 3.
journal title abbreviation: Elife
publication date: 2014-12-19T00:00:00
year: 2014
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 61409
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury.

Authorship 121737
type: Authorship
author rank in publication: 1
linked author: Chiu, Isaac
linked information resource: Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology.

Authorship 342247
type: Authorship
author rank in publication: 1
linked author: Chiu, Isaac
linked information resource: T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS.

Authorship 785491
type: Authorship
author rank in publication: 4
linked author: Chiu, Isaac
linked information resource: Targeted delivery of siRNA to macrophages for anti-inflammatory treatment.

Authorship 799665
type: Authorship
author rank in publication: 1
linked author: Chiu, Isaac
linked information resource: Correction: Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity.

Targeted delivery of siRNA to macrophages for anti-inflammatory treatment.
PubMed Identifier: 20216529
author list: Kim SS, Ye C, Kumar P, Chiu I, Subramanya S, Wu H, Shankar P, Manjunath N
published in: Molecular therapy : the journal of the American Society of Gene Therapy
information resource reference: Targeted delivery of siRNA to macrophages for anti-inflammatory treatment. Mol Ther. 2010 May; 18(5):993-1001.
journal title abbreviation: Mol Ther
publication date: 2010-03-09T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Correction: Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity.
PubMed Identifier: 25658835
author list: Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman G, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf C
published in: eLife
information resource reference: Correction: Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity. Elife. 2015 Feb 06; 4:e06720.
journal title abbreviation: Elife
publication date: 2015-02-06T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 313240
type: Authorship
author rank in publication: 4
linked author: Chiu, Isaac
linked information resource: Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction.

Authorship 413719
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: Identification of the target self-antigens in reperfusion injury.

Biomedical Informatics
type: Department
type: Organization

Authorship 296439
type: Authorship
author rank in publication: 2
linked author: Chiu, Isaac
linked information resource: MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression.

Authorship 817924
type: Authorship
author rank in publication: 11
linked author: Chiu, Isaac
linked information resource: Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.

Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.
PubMed Identifier: 26119026
author list: Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ
published in: Neuron
information resource reference: Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. 2015 Jul 15; 87(2):341-54.
journal title abbreviation: Neuron
publication date: 2015-06-25T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 850630
type: Authorship
author rank in publication: 2
linked author: Chiu, Isaac
linked information resource: CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity.

CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity.
PubMed Identifier: 26598697
author list: Ghasemlou N, Chiu IM, Julien JP, Woolf CJ
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):E6808-17.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2015-11-23T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 882225
type: Authorship
author rank in publication: 1
linked author: Chiu, Isaac
linked information resource: Pain and infection: pathogen detection by nociceptors.

Pain and infection: pathogen detection by nociceptors.
PubMed Identifier: 27183444
author list: Chiu IM, Pinho-Ribeiro FA, Woolf CJ
published in: Pain
information resource reference: Pain and infection: pathogen detection by nociceptors. Pain. 2016 06; 157(6):1192-1193.
journal title abbreviation: Pain
publication date: 2016-06-01T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 885581
type: Authorship
author rank in publication: 4
linked author: Chiu, Isaac
linked information resource: Pain and Itch: Beneficial or Harmful to Antimicrobial Defense?

Pain and Itch: Beneficial or Harmful to Antimicrobial Defense?
PubMed Identifier: 27281567
author list: Baral P, Mills K, Pinho-Ribeiro FA, Chiu IM
published in: Cell host & microbe
information resource reference: Pain and Itch: Beneficial or Harmful to Antimicrobial Defense? Cell Host Microbe. 2016 Jun 08; 19(6):755-9.
journal title abbreviation: Cell Host Microbe
publication date: 2016-06-08T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Assistant Professor
sort order: 2
type: Faculty Rank

Fellow or Post Doc
sort order: 6
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Instructor
sort order: 4
type: Faculty Rank

Authorship 61773
type: Authorship
author rank in publication: 1
linked author: Chiu, Isaac
linked information resource: Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

The Role of Direct Pathogen Detection by Sensory Neurons in Combating Bacterial I
end date: 2013-07-31
principal investigator name: CHIU, ISAAC MING-CHENG
start date: 2011-08-01
type: Grant
sponsor award id: F32NS076297

The role of nociceptor neurons in bacterial host defense and inflammation
end date: 2017-03-31
principal investigator name: CHIU, ISAAC MING-CHENG
start date: 2015-04-15
type: Grant
sponsor award id: K22AI114810

Principal Investigator
type: Researcher Role
researcher role of: Chiu, Isaac
contributes to: The Role of Direct Pathogen Detection by Sensory Neurons in Combating Bacterial I

Principal Investigator
type: Researcher Role
researcher role of: Chiu, Isaac
contributes to: The role of nociceptor neurons in bacterial host defense and inflammation

Sensory Neuron-Bacteria Interactions in Modulating Pain and the Host Microbiota
end date: 2021-06-30
principal investigator name: CHIU, ISAAC MING-CHENG
start date: 2016-09-30
type: Grant
sponsor award id: DP2AT009499

Principal Investigator
type: Researcher Role
researcher role of: Chiu, Isaac
contributes to: Sensory Neuron-Bacteria Interactions in Modulating Pain and the Host Microbiota

77 Avenue Louis Pasteur
type: Address
address line 1: Harvard Medical School
address line 2: 4 Blackfan Circle Building, Room 812A
address line 3: 77 Avenue Louis Pasteur
city: Boston
postal code: 02115
state or province: MA

Authorship 929857
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation.

Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation.
PubMed Identifier: 27793571
author list: Pinho-Ribeiro FA, Verri WA, Chiu IM
published in: Trends in immunology
information resource reference: Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation. Trends Immunol. 2017 Jan; 38(1):5-19.
journal title abbreviation: Trends Immunol
publication date: 2016-10-25T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 271675
type: Authorship
author rank in publication: 9
linked author: Chiu, Isaac
linked information resource: Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injury.

Authorship 948509
type: Authorship
author rank in publication: 2
linked author: Chiu, Isaac
linked information resource: Bacterial Signaling to the Nervous System through Toxins and Metabolites.

Bacterial Signaling to the Nervous System through Toxins and Metabolites.
PubMed Identifier: 28065740
author list: Yang NJ, Chiu IM
published in: Journal of molecular biology
information resource reference: Bacterial Signaling to the Nervous System through Toxins and Metabolites. J Mol Biol. 2017 03 10; 429(5):587-605.
journal title abbreviation: J Mol Biol
publication date: 2017-01-06T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 955055
type: Authorship
author rank in publication: 1
linked author: Chiu, Isaac
linked information resource: Infection, Pain, and Itch.

Authorship 955399
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence.

Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence.
PubMed Identifier: 28155242
author list: Lai NY, Mills K, Chiu IM
published in: Journal of internal medicine
information resource reference: Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence. J Intern Med. 2017 07; 282(1):5-23.
journal title abbreviation: J Intern Med
publication date: 2017-02-02T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Infection, Pain, and Itch.
PubMed Identifier: 28144843
author list: Chiu IM
published in: Neuroscience bulletin
information resource reference: Infection, Pain, and Itch. Neurosci Bull. 2018 Feb; 34(1):109-119.
journal title abbreviation: Neurosci Bull
publication date: 2017-01-31T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 966917
type: Authorship
author rank in publication: 9
linked author: Chiu, Isaac
linked information resource: An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk.

An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk.
PubMed Identifier: 28262351
author list: Yissachar N, Zhou Y, Ung L, Lai NY, Mohan JF, Ehrlicher A, Weitz DA, Kasper DL, Chiu IM, Mathis D, Benoist C
published in: Cell
information resource reference: An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk. Cell. 2017 03 09; 168(6):1135-1148.e12.
journal title abbreviation: Cell
publication date: 2017-03-02T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction.
PubMed Identifier: 20462867
author list: Haas MS, Alicot EM, Schuerpf F, Chiu I, Li J, Moore FD, Carroll MC
published in: Cardiovascular research
information resource reference: Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction. Cardiovasc Res. 2010 Sep 01; 87(4):618-27.
journal title abbreviation: Cardiovasc Res
publication date: 2010-05-11T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injury.
PubMed Identifier: 16942749
author list: Fu J, Lin G, Wu Z, Ceng B, Wu Y, Liang G, Qin G, Li J, Chiu I, Liu D
published in: Biochemical and biophysical research communications
information resource reference: Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injury. Biochem Biophys Res Commun. 2006 Oct 20; 349(2):504-12.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 2006-08-22T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Trafficking of spontaneously endocytosed MHC proteins.
PubMed Identifier: 10570178
author list: Chiu I, Davis DM, Strominger JL
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Trafficking of spontaneously endocytosed MHC proteins. Proc Natl Acad Sci U S A. 1999 Nov 23; 96(24):13944-9.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1999-11-23T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression.
PubMed Identifier: 14718661
author list: Deng LW, Chiu I, Strominger JL
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression. Proc Natl Acad Sci U S A. 2004 Jan 20; 101(3):757-62.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2004-01-12T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Suppression of complement regulatory protein C1 inhibitor in vascular endothelial activation by inhibiting vascular cell adhesion molecule-1 action.
PubMed Identifier: 17521609
author list: Zhang H, Qin G, Liang G, Li J, Chiu I, Barrington RA, Liu D
published in: Biochemical and biophysical research communications
information resource reference: Suppression of complement regulatory protein C1 inhibitor in vascular endothelial activation by inhibiting vascular cell adhesion molecule-1 action. Biochem Biophys Res Commun. 2007 Jul 13; 358(4):1120-7.
journal title abbreviation: Biochem Biophys Res Commun
publication date: 2007-05-22T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury.
PubMed Identifier: 14999103
author list: Zhang M, Austen WG, Chiu I, Alicot EM, Hung R, Ma M, Verna N, Xu M, Hechtman HB, Moore FD, Carroll MC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3886-91.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2004-03-03T00:00:00
year: 2004
type: Academic Article
type: Article
type: Document
type: Information Resource

Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis.
PubMed Identifier: 17060494
author list: Ma Y, Li J, Chiu I, Wang Y, Sloane JA, Lü J, Kosaras B, Sidman RL, Volpe JJ, Vartanian T
published in: The Journal of cell biology
information resource reference: Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. J Cell Biol. 2006 Oct 23; 175(2):209-15.
journal title abbreviation: J Cell Biol
publication date: 2006-10-23T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Impaired spontaneous endocytosis of HLA-G.
PubMed Identifier: 9368631
author list: Davis DM, Reyburn HT, Pazmany L, Chiu I, Mandelboim O, Strominger JL
published in: European journal of immunology
information resource reference: Impaired spontaneous endocytosis of HLA-G. Eur J Immunol. 1997 Oct; 27(10):2714-9.
journal title abbreviation: Eur J Immunol
publication date: 1997-10-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1004240
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: Neuro-immune interactions in allergic diseases: novel targets for therapeutics.

Neuro-immune interactions in allergic diseases: novel targets for therapeutics.
PubMed Identifier: 28814067
author list: Voisin T, Bouvier A, Chiu IM
published in: International immunology
information resource reference: Neuro-immune interactions in allergic diseases: novel targets for therapeutics. Int Immunol. 2017 06 01; 29(6):247-261.
journal title abbreviation: Int Immunol
publication date: 2017-06-01T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1011173
type: Authorship
author rank in publication: 19
linked author: Chiu, Isaac
linked information resource: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.
PubMed Identifier: 28902842
author list: Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK
published in: Nature
information resource reference: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Nature. 2017 09 21; 549(7672):351-356.
journal title abbreviation: Nature
publication date: 2017-09-13T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.
PubMed Identifier: 19933335
author list: Chiu IM, Phatnani H, Kuligowski M, Tapia JC, Carrasco MA, Zhang M, Maniatis T, Carroll MC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice. Proc Natl Acad Sci U S A. 2009 Dec 08; 106(49):20960-5.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2009-11-20T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1014357
type: Authorship
author rank in publication: 3
linked author: Chiu, Isaac
linked information resource: Neuro-immune interactions in inflammation and host defense: Implications for transplantation.

Neuro-immune interactions in inflammation and host defense: Implications for transplantation.
PubMed Identifier: 28941325
author list: Chavan SS, Ma P, Chiu IM
published in: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
information resource reference: Neuro-immune interactions in inflammation and host defense: Implications for transplantation. Am J Transplant. 2018 03; 18(3):556-563.
journal title abbreviation: Am J Transplant
publication date: 2017-10-27T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Pain and Neuro-immune Signaling in S. pyogenes pathogenesis
end date: 2022-08-31
principal investigator name: CHIU, ISAAC MING-CHENG
start date: 2017-09-25
type: Grant
sponsor award id: R01AI130019

Principal Investigator
type: Researcher Role
researcher role of: Chiu, Isaac
contributes to: Pain and Neuro-immune Signaling in S. pyogenes pathogenesis

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS.
PubMed Identifier: 18997009
author list: Chiu IM, Chen A, Zheng Y, Kosaras B, Tsiftsoglou SA, Vartanian TK, Brown RH, Carroll MC
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17913-8.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2008-11-07T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology.
PubMed Identifier: 22837035
author list: Chiu IM, von Hehn CA, Woolf CJ
published in: Nature neuroscience
information resource reference: Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology. Nat Neurosci. 2012 Jul 26; 15(8):1063-7.
journal title abbreviation: Nat Neurosci
publication date: 2012-07-26T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1027214
type: Authorship
author rank in publication: 19
linked author: Chiu, Isaac
linked information resource: Erratum: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.

Erratum: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.
PubMed Identifier: 29143821
author list: Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK
published in: Nature
information resource reference: Erratum: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Nature. 2017 11 30; 551(7682):658.
journal title abbreviation: Nature
publication date: 2017-11-15T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1036022
type: Authorship
author rank in publication: 12
linked author: Chiu, Isaac
linked information resource: Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314.

Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314.
PubMed Identifier: 29295977
author list: Blake KJ, Baral P, Voisin T, Lubkin A, Pinho-Ribeiro FA, Adams KL, Roberson DP, Ma YC, Otto M, Woolf CJ, Torres VJ, Chiu IM
published in: Nature communications
information resource reference: Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314. Nat Commun. 2018 01 02; 9(1):37.
journal title abbreviation: Nat Commun
publication date: 2018-01-02T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

The human natural killer cell immune synapse.
PubMed Identifier: 10611338
author list: Davis DM, Chiu I, Fassett M, Cohen GB, Mandelboim O, Strominger JL
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: The human natural killer cell immune synapse. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):15062-7.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 1999-12-21T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource