JAB3JoshuaBoyceJoshua A. Boyce, M.D.42.33510370000000-71.1061649000000014450Boyce, JoshuaA.The overall goal of my lab is to apply principals of pathophysiology of allergic diseases in humans to questions at the bench, and in turn to bring fundamental findings made at the bench back to the clinic. The dominant themes include how lipid mediators and their receptors function in a network to control the development and activation of mast cells, a central cell type in the effector phases of all allergic diseases. We defined the growth factor requirements for the development of human mast cells from their earliest progenitors, and identified a key role for interleukin (IL)-4 as an accessory mitogen. Human mast cells exposed to IL-4 become competent to generate leukotriene C4 (LTC4) the precursor of the powerful bronchoconstrictor LTD4 and the stable metabolite LTE4. This competence is due to the induced expression of LTC4 synthase, the requisite terminal enzyme involved in LTC4 synthesis. These observations explain why mucosal inflammation elicits a mast cell hyperplasia accompanied by strikingly increased regional concentrations of LTC4 LTD4 and LTE4. We discovered that the growth potentiating effect of IL-4 depended on the induction of LTC4S, and the transactivation of the c-kit tyrosine kinase by the type 1 receptor for cys-LTs (CysLT1R). We also demonstrated that CysLT1R on mast cells exists as a heterodimer with the type 2 receptor for cys-LTs (CysLT2R), and that the latter is a potent negative regulator of the former. Most recently, we discovered that LTE4 only a weak agonist of CysLT1R and CysLT2R, is the most potent member of this mediator class for causing chemokine generation by mast cells and potentiating pulmonary inflammation in mice. These actions are due to the purinergic receptor P2Y12, which we have shown to be the long-elusive third cys-LT receptor. We plan to translate these observations into the clinic, and will test the efficacy of a P2Y12 antagonist on clinical reactions to aspirin challenge in aspirin-intolerant asthmatic individuals as a major goal of a U19 funded by NIAID.
617/525-1261Albert L. Sheffer Professor of Medicine in the Field of Allergic Diseasecatalyst:eCommonsLogineCommons Loginprns:awardConferredByaward conferred byprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor ReceiptDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:overviewoverviewvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 1048752229477727Samuchiwal SK, Boyce JAThe Journal of allergy and clinical immunologyRole of lipid mediators and control of lymphocyte responses in type 2 immunopathology. J Allergy Clin Immunol. 2018 04; 141(4):1182-1190.J Allergy Clin Immunol2018-03-02T00:00:002018Role of lipid mediators and control of lymphocyte responses in type 2 immunopathology.10973484Ochi H, De Jesus NH, Hsieh FH, Austen KF, Boyce JAProceedings of the National Academy of Sciences of the United States of AmericaIL-4 and -5 prime human mast cells for different profiles of IgE-dependent cytokine production. Proc Natl Acad Sci U S A. 2000 Sep 12; 97(19):10509-13.Proc Natl Acad Sci U S A2000-09-12T00:00:002000IL-4 and -5 prime human mast cells for different profiles of IgE-dependent cytokine production.19124756Jiang Y, Borrelli L, Bacskai BJ, Kanaoka Y, Boyce JAJournal of immunology (Baltimore, Md. : 1950)P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells. J Immunol. 2009 Jan 15; 182(2):1129-37.J Immunol2009-01-15T00:00:002009P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells.9820483Yuan Q, Gurish MF, Friend DS, Austen KF, Boyce JAJournal of immunology (Baltimore, Md. : 1950)Generation of a novel stem cell factor-dependent mast cell progenitor. J Immunol. 1998 Nov 15; 161(10):5143-6.J Immunol1998-11-15T00:00:001998Generation of a novel stem cell factor-dependent mast cell progenitor.12023373Gurish MF, Humbles A, Tao H, Finkelstein S, Boyce JA, Gerard C, Friend DS, Austen KFJournal of immunology (Baltimore, Md. : 1950)CCR3 is required for tissue eosinophilia and larval cytotoxicity after infection with Trichinella spiralis. J Immunol. 2002 Jun 01; 168(11):5730-6.J Immunol2002-06-01T00:00:002002CCR3 is required for tissue eosinophilia and larval cytotoxicity after infection with Trichinella spiralis.16682274Lin DA, Boyce JAAdvances in immunologyLysophospholipids as mediators of immunity. Adv Immunol. 2006; 89:141-67.Adv Immunol2006-01-01T00:00:002006Lysophospholipids as mediators of immunity.Authorship 10670613028449793Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JAJournal of the Academy of Nutrition and DieteticsAddendum Guidelines for the Prevention of Peanut Allergy in the United States: Summary of the National Institute of Allergy and Infectious Diseases-Sponsored Expert Panel. J Acad Nutr Diet. 2017 05; 117(5):788-793.J Acad Nutr Diet2017-05-01T00:00:002017Addendum Guidelines for the Prevention of Peanut Allergy in the United States: Summary of the National Institute of Allergy and Infectious Diseases-Sponsored Expert Panel.12532090Boyce JAThe Journal of allergy and clinical immunologyMast cells: beyond IgE. J Allergy Clin Immunol. 2003 Jan; 111(1):24-32; quiz 33.J Allergy Clin Immunol2003-01-01T00:00:002003Mast cells: beyond IgE.12895603Boyce JAProstaglandins, leukotrienes, and essential fatty acidsThe role of mast cells in asthma. Prostaglandins Leukot Essent Fatty Acids. 2003 Aug-Sep; 69(2-3):195-205.Prostaglandins Leukot Essent Fatty Acids2003-08-01T00:00:002003The role of mast cells in asthma.22010907Bunyavanich S, Boyce JA, Raby BA, Weiss STClinical and experimental allergy : journal of the British Society for Allergy and Clinical ImmunologyGene-by-environment effect of house dust mite on purinergic receptor P2Y12 (P2RY12) and lung function in children with asthma. Clin Exp Allergy. 2012 Feb; 42(2):229-37.Clin Exp Allergy2012-02-01T00:00:002012Gene-by-environment effect of house dust mite on purinergic receptor P2Y12 (P2RY12) and lung function in children with asthma.11929779Boyce JA, Mellor EA, Perkins B, Lim YC, Luscinskas FWBloodHuman mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions. Blood. 2002 Apr 15; 99(8):2890-6.Blood2002-04-15T00:00:002002Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions.Authorship 10730521029890239Laidlaw TM, Cahill KN, Cardet JC, Murphy K, Cui J, Dioneda B, Kothari P, Raby BA, Israel E, Boyce JAThe Journal of allergy and clinical immunologyA trial of type 12 purinergic (P2Y12) receptor inhibition with prasugrel identifies a potentially distinct endotype of patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2019 01; 143(1):316-324.e7.J Allergy Clin Immunol2018-06-08T00:00:002018A trial of type 12 purinergic (P2Y12) receptor inhibition with prasugrel identifies a potentially distinct endotype of patients with aspirin-exacerbated respiratory disease.21987705Burks AW, Jones SM, Boyce JA, Sicherer SH, Wood RA, Assa'ad A, Sampson HAPediatricsNIAID-sponsored 2010 guidelines for managing food allergy: applications in the pediatric population. Pediatrics. 2011 Nov; 128(5):955-65.Pediatrics2011-10-10T00:00:002011NIAID-sponsored 2010 guidelines for managing food allergy: applications in the pediatric population.17498059Boyce JAImmunological reviewsMast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulation. Immunol Rev. 2007 Jun; 217:168-85.Immunol Rev2007-06-01T00:00:002007Mast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulation.Authorship 1082746721185960Boyce JA, Assa'ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJJournal of the American Dietetic AssociationGuidelines for the Diagnosis and Management of Food Allergy in the United States: summary of the NIAID-sponsored expert panel report. J Am Diet Assoc. 2011 Jan; 111(1):17-27.J Am Diet Assoc2011-01-01T00:00:002011Guidelines for the Diagnosis and Management of Food Allergy in the United States: summary of the NIAID-sponsored expert panel report.30017554Pan D, Buchheit KM, Samuchiwal SK, Liu T, Cirka H, Raff H, Boyce JAThe Journal of allergy and clinical immunologyCOX-1 mediates IL-33-induced extracellular signal-regulated kinase activation in mast cells: Implications for aspirin sensitivity. J Allergy Clin Immunol. 2019 03; 143(3):1047-1057.e8.J Allergy Clin Immunol2018-07-12T00:00:002018COX-1 mediates IL-33-induced extracellular signal-regulated kinase activation in mast cells: Implications for aspirin sensitivity.16750978Metcalfe DD, Boyce JAThe Journal of allergy and clinical immunologyMast cell biology in evolution. J Allergy Clin Immunol. 2006 Jun; 117(6):1227-9.J Allergy Clin Immunol2006-05-11T00:00:002006Mast cell biology in evolution.Authorship 1111971Authorship 10892301630135581Ordovas-Montanes J, Dwyer DF, Nyquist SK, Buchheit KM, Vukovic M, Deb C, Wadsworth MH, Hughes TK, Kazer SW, Yoshimoto E, Cahill KN, Bhattacharyya N, Katz HR, Berger B, Laidlaw TM, Boyce JA, Barrett NA, Shalek AKNatureAllergic inflammatory memory in human respiratory epithelial progenitor cells. Nature. 2018 08; 560(7720):649-654.Nature2018-08-22T00:00:002018Allergic inflammatory memory in human respiratory epithelial progenitor cells.19822647Paruchuri S, Tashimo H, Feng C, Maekawa A, Xing W, Jiang Y, Kanaoka Y, Conley P, Boyce JAThe Journal of experimental medicineLeukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor. J Exp Med. 2009 Oct 26; 206(11):2543-55.J Exp Med2009-10-12T00:00:002009Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor.21768379Cozzi E, Ackerman KG, Lundequist A, Drazen JM, Boyce JA, Beier DRProceedings of the National Academy of Sciences of the United States of AmericaThe naive airway hyperresponsiveness of the A/J mouse is Kit-mediated. Proc Natl Acad Sci U S A. 2011 Aug 02; 108(31):12787-92.Proc Natl Acad Sci U S A2011-07-18T00:00:002011The naive airway hyperresponsiveness of the A/J mouse is Kit-mediated.Authorship 1090257230165055Bankova LG, Boyce JAThe Journal of allergy and clinical immunologyA new spin on mast cells and cysteinyl leukotrienes: Leukotriene E4 activates mast cells in vivo. J Allergy Clin Immunol. 2018 10; 142(4):1056-1057.J Allergy Clin Immunol2018-08-28T00:00:002018A new spin on mast cells and cysteinyl leukotrienes: Leukotriene E4 activates mast cells in vivo.19281904Boyce JA, Broide D, Matsumoto K, Bochner BSThe Journal of allergy and clinical immunologyAdvances in mechanisms of asthma, allergy, and immunology in 2008. J Allergy Clin Immunol. 2009 Mar; 123(3):569-74.J Allergy Clin Immunol2009-03-01T00:00:002009Advances in mechanisms of asthma, allergy, and immunology in 2008.20159240Finkelman FD, Boyce JA, Vercelli D, Rothenberg METhe Journal of allergy and clinical immunologyKey advances in mechanisms of asthma, allergy, and immunology in 2009. J Allergy Clin Immunol. 2010 Feb; 125(2):312-8.J Allergy Clin Immunol2010-02-01T00:00:002010Key advances in mechanisms of asthma, allergy, and immunology in 2009.22284930Boyce JA, Bochner B, Finkelman FD, Rothenberg METhe Journal of allergy and clinical immunologyAdvances in mechanisms of asthma, allergy, and immunology in 2011. J Allergy Clin Immunol. 2012 Feb; 129(2):335-41.J Allergy Clin Immunol2012-02-01T00:00:002012Advances in mechanisms of asthma, allergy, and immunology in 2011.7540656Boyce JA, Friend D, Matsumoto R, Austen KF, Owen WFThe Journal of experimental medicineDifferentiation in vitro of hybrid eosinophil/basophil granulocytes: autocrine function of an eosinophil developmental intermediate. J Exp Med. 1995 Jul 01; 182(1):49-57.J Exp Med1995-07-01T00:00:001995Differentiation in vitro of hybrid eosinophil/basophil granulocytes: autocrine function of an eosinophil developmental intermediate.15585881Feng C, Mery AG, Beller EM, Favot C, Boyce JAJournal of immunology (Baltimore, Md. : 1950)Adenine nucleotides inhibit cytokine generation by human mast cells through a Gs-coupled receptor. J Immunol. 2004 Dec 15; 173(12):7539-47.J Immunol2004-12-15T00:00:002004Adenine nucleotides inhibit cytokine generation by human mast cells through a Gs-coupled receptor.16357326Feng C, Beller EM, Bagga S, Boyce JABloodHuman mast cells express multiple EP receptors for prostaglandin E2 that differentially modulate activation responses. Blood. 2006 Apr 15; 107(8):3243-50.Blood2005-12-15T00:00:002005Human mast cells express multiple EP receptors for prostaglandin E2 that differentially modulate activation responses.Authorship 1059964Authorship 1099807530339852Cahill KN, Murphy K, Singer J, Israel E, Boyce JA, Laidlaw TMThe Journal of allergy and clinical immunologyPlasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2019 02; 143(2):799-803.e2.J Allergy Clin Immunol2018-10-16T00:00:002018Plasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease.19647860Austen KF, Maekawa A, Kanaoka Y, Boyce JAThe Journal of allergy and clinical immunologyThe leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. J Allergy Clin Immunol. 2009 Sep; 124(3):406-14; quiz 415-6.J Allergy Clin Immunol2009-08-03T00:00:002009The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications.21167411Boyce JA, Assa'ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, Bahna SL, Beck LA, Byrd-Bredbenner C, Camargo CA, Eichenfield L, Furuta GT, Hanifin JM, Jones C, Kraft M, Levy BD, Lieberman P, Luccioli S, McCall KM, Schneider LC, Simon RA, Simons FE, Teach SJ, Yawn BP, Schwaninger JMJournal of the American Academy of DermatologyGuidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-Sponsored Expert Panel report. J Am Acad Dermatol. 2011 Jan; 64(1):175-92.J Am Acad Dermatol2011-01-01T00:00:002011Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-Sponsored Expert Panel report.22511759Adachi R, Krilis SA, Nigrovic PA, Hamilton MJ, Chung K, Thakurdas SM, Boyce JA, Anderson P, Stevens RLThe Journal of biological chemistryRas guanine nucleotide-releasing protein-4 (RasGRP4) involvement in experimental arthritis and colitis. J Biol Chem. 2012 Jun 08; 287(24):20047-55.J Biol Chem2012-04-16T00:00:002012Ras guanine nucleotide-releasing protein-4 (RasGRP4) involvement in experimental arthritis and colitis.8626689Penrose JF, Spector J, Baldasaro M, Xu K, Boyce J, Arm JP, Austen KF, Lam BKThe Journal of biological chemistryMolecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35. J Biol Chem. 1996 May 10; 271(19):11356-61.J Biol Chem1996-05-10T00:00:001996Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35.19587017Moore ML, Newcomb DC, Parekh VV, Van Kaer L, Collins RD, Zhou W, Goleniewska K, Chi MH, Mitchell D, Boyce JA, Durbin JE, Sturkie C, Peebles RSJournal of immunology (Baltimore, Md. : 1950)STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. J Immunol. 2009 Aug 01; 183(3):2016-26.J Immunol2009-07-08T00:00:002009STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection.8943871Boyce JA, Lam BK, Penrose JF, Friend DS, Parsons S, Owen WF, Austen KFBloodExpression of LTC4 synthase during the development of eosinophils in vitro from cord blood progenitors. Blood. 1996 Dec 01; 88(11):4338-47.Blood1996-12-01T00:00:001996Expression of LTC4 synthase during the development of eosinophils in vitro from cord blood progenitors.23650617Ohta S, Imamura M, Xing W, Boyce JA, Balestrieri BJournal of immunology (Baltimore, Md. : 1950)Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation. J Immunol. 2013 Jun 15; 190(12):5927-38.J Immunol2013-05-06T00:00:002013Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation.Authorship 11278651030664709Liu T, Barrett NA, Kanaoka Y, Buchheit K, Laidlaw TM, Garofalo D, Lai J, Katz HR, Feng C, Boyce JAMucosal immunologyCysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism. Mucosal Immunol. 2019 05; 12(3):679-690.Mucosal Immunol2019-01-21T00:00:002019Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism.Authorship 1265681Authorship 1131971Authorship 1146017830978291Cahill KN, Cui J, Kothari P, Murphy K, Raby BA, Singer J, Israel E, Boyce JA, Laidlaw TMAmerican journal of respiratory and critical care medicineUnique Effect of Aspirin Therapy on Biomarkers in Aspirin-exacerbated Respiratory Disease. A Prospective Trial. Am J Respir Crit Care Med. 2019 09 15; 200(6):704-711.Am J Respir Crit Care Med2019-09-15T00:00:002019Unique Effect of Aspirin Therapy on Biomarkers in Aspirin-exacerbated Respiratory Disease. A Prospective Trial.D008407Anatomy37315420.56641Mast CellsD015289Chemicals & Drugs872550.856558LeukotrienesD055963Disorders401820.754164Asthma, Aspirin-InducedD021183Disorders491630.822471Peanut HypersensitivityD018077Chemicals & Drugs341230.899939Receptors, LeukotrieneEmeritusMedicinePediatricsWomen's HealthEmergency MedicineBrigham and Women's HospitalMassachusetts General HospitalNAB4NoraBarrettNora Amanda Barrett, M.D.42.33510370000000-71.1061649000000072240Barrett, NoraAssociate Professor of MedicineKAustenK Frank Austen, M.D.42.33729300000000-71.1076350000000069279Austen, KAstrazeneca Professor of Respiratory and Inflammatory Diseases in the Department of Medicine, EmeritusDRW6DuaneWesemannDuane Wesemann, M.D., Ph.D.42.33510370000000-71.1061649000000021617Wesemann, DuaneAssociate Professor of MedicineCAC9CarlosCamargoCarlos Arturo Camargo, Jr., Dr.P.H., M.D.42.36100000000000-71.0691983000000025636Camargo, CarlosProfessor of Emergency Medicine11163selected publications9.038430.00417002584research areas8.187190.012630876coauthor of292.9924.245660similar toMCC1MariaCastellsMaria Concepcion Castells, M.D., Ph.D.42.33729300000000-71.1076350000000060393Castells, MariaProfessor of MedicineCF27ChunliFengChunli Feng, M.D.42.33729300000000-71.1076350000000045058Feng, ChunliResearch Associate in MedicineAL169AnnieLewis-O'ConnorAnnie Lewis-O'Connor, Ph.D.42.33510370000000-71.1061649000000068264Lewis-O'Connor, AnnieInstructor in MedicineTML9TanyaLaidlawTanya Maria Laidlaw, M.D.42.33510370000000-71.1061649000000021068Laidlaw, TanyaAssociate Professor of MedicineKMB52KathleenBuchheitKathleen Mary Buchheit, M.D.92552Buchheit, KathleenAssistant Professor of MedicineLGB14LoraBankovaLora Georgieva Bankova, M.D.42.33510370000000-71.1061649000000091456Bankova, LoraAssistant Professor of MedicineAuthorship 1192275131560800Boyce JAAllergyLegends of allergy and immunology: K. Frank Austen. Allergy. 2020 04; 75(4):1001-1002.Allergy2019-10-21T00:00:002019Legends of allergy and immunology: K. Frank Austen.Authorship 1630451Authorship 1087305Authorship 1196486131587797Boyce JAThe Journal of allergy and clinical immunologyAspirin sensitivity: Lessons in the regulation (and dysregulation) of mast cell function. J Allergy Clin Immunol. 2019 10; 144(4):875-881.J Allergy Clin Immunol2019-10-01T00:00:002019Aspirin sensitivity: Lessons in the regulation (and dysregulation) of mast cell function.Authorship 11992651131638598Nagai J, Balestrieri B, Fanning LB, Kyin T, Cirka H, Lin J, Idzko M, Zech A, Kim EY, Brennan PJ, Boyce JAThe Journal of clinical investigationP2Y6 signaling in alveolar macrophages prevents leukotriene-dependent type 2 allergic lung inflammation. J Clin Invest. 2019 12 02; 129(12):5169-5186.J Clin Invest2019-12-02T00:00:002019P2Y6 signaling in alveolar macrophages prevents leukotriene-dependent type 2 allergic lung inflammation.Authorship 1204772131738995Boyce JAThe Journal of allergy and clinical immunologyMast cells can be commandeered for staphylococcal pathogenicity in patients with chronic rhinosinusitis with nasal polyposis. J Allergy Clin Immunol. 2020 01; 145(1):103-104.J Allergy Clin Immunol2019-11-15T00:00:002019Mast cells can be commandeered for staphylococcal pathogenicity in patients with chronic rhinosinusitis with nasal polyposis.true1Instructor in MedicineInstructor in MedicineAuthorship 12359171232199912Buchheit KM, Dwyer DF, Ordovas-Montanes J, Katz HR, Lewis E, Vukovic M, Lai J, Bankova LG, Bhattacharyya N, Shalek AK, Barrett NA, Boyce JA, Laidlaw TMThe Journal of allergy and clinical immunologyIL-5Ra marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2020 06; 145(6):1574-1584.J Allergy Clin Immunol2020-03-19T00:00:002020IL-5Ra marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease.Authorship 12493353532413319Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovic M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi LE, Barbry P, Leslie A, Kiem HP, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK, Ordovas-Montanes JCellSARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell. 2020 05 28; 181(5):1016-1035.e19.Cell2020-04-27T00:00:002020SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.Authorship 1626376Authorship 1271337432735807Wang L, Foer D, Bates DW, Boyce JA, Zhou LThe Journal of allergy and clinical immunologyRisk factors for hospitalization, intensive care, and mortality among patients with asthma and COVID-19. J Allergy Clin Immunol. 2020 10; 146(4):808-812.J Allergy Clin Immunol2020-07-29T00:00:002020Risk factors for hospitalization, intensive care, and mortality among patients with asthma and COVID-19.Authorship 1355551Authorship 1286340532946563Derakhshan T, Samuchiwal SK, Hallen N, Bankova LG, Boyce JA, Barrett NA, Austen KF, Dwyer DFThe Journal of experimental medicineLineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation. J Exp Med. 2021 01 04; 218(1).J Exp Med2021-01-04T00:00:002021Lineage-specific regulation of inducible and constitutive mast cells in allergic airway inflammation.33285161Liu T, Barrett NA, Nagai J, Lai J, Feng C, Boyce JAThe Journal of allergy and clinical immunologyLeukotriene D4 paradoxically limits LTC4-driven platelet activation and lung immunopathology. J Allergy Clin Immunol. 2021 07; 148(1):195-208.e5.J Allergy Clin Immunol2020-12-04T00:00:002020Leukotriene D4 paradoxically limits LTC4-driven platelet activation and lung immunopathology.Authorship 13127456Allergy and Clinical ImmunologyAuthorship 218862Authorship 13343092233637594Dwyer DF, Ordovas-Montanes J, Allon SJ, Buchheit KM, Vukovic M, Derakhshan T, Feng C, Lai J, Hughes TK, Nyquist SK, Giannetti MP, Berger B, Bhattacharyya N, Roditi RE, Katz HR, Nawijn MC, Berg M, van den Berge M, Laidlaw TM, Shalek AK, Barrett NA, Boyce JAScience immunologyHuman airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation. Sci Immunol. 2021 02 26; 6(56).Sci Immunol2021-02-26T00:00:002021Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation.33805900Baek SH, Foer D, Cahill KN, Israel E, Maiorino E, Röhl A, Boyce JA, Weiss STJournal of personalized medicineSystems Approaches to Treatment Response to Imatinib in Severe Asthma: A Pilot Study. J Pers Med. 2021 Mar 25; 11(4).J Pers Med2021-03-25T00:00:002021Systems Approaches to Treatment Response to Imatinib in Severe Asthma: A Pilot Study.Authorship 13432417Authorship 1349420233872654Dwyer DF, Boyce JAThe Journal of allergy and clinical immunologyNeonatal mast cells and transplacental IgE transfer: A mechanism of disease inheritance or of passive infant barrier defense? J Allergy Clin Immunol. 2021 07; 148(1):76-77.J Allergy Clin Immunol2021-04-16T00:00:002021Neonatal mast cells and transplacental IgE transfer: A mechanism of disease inheritance or of passive infant barrier defense?Authorship 1370284234183166Dwyer DF, Boyce JAThe Journal of allergy and clinical immunologyReply. J Allergy Clin Immunol. 2021 09; 148(3):904.J Allergy Clin Immunol2021-06-26T00:00:002021Reply.true1Assistant Professor of MedicineAssistant Professor of Medicinetrue1Assistant Professor of MedicineAssistant Professor of Medicinetrue1Associate Professor of MedicineAssociate Professor of Medicinetrue1Associate Professor of MedicineAssociate Professor of Medicinetrue1Assistant Professor of MedicineAssistant Professor of Medicinetrue1Associate Professor of MedicineAssociate Professor of Medicinetrue1Professor of MedicineProfessor of MedicineAuthorship 1389686234464635Mullol J, Boyce J, Dahlén SE, Dahlén B, Picado C, Bobolea IThe Journal of allergy and clinical immunologyEicosanoid dysregulation and type 2 inflammation in AERD. J Allergy Clin Immunol. 2021 11; 148(5):1157-1160.J Allergy Clin Immunol2021-08-28T00:00:002021Eicosanoid dysregulation and type 2 inflammation in AERD.Authorship 14193841034932383Ualiyeva S, Lemire E, Aviles EC, Wong C, Boyd AA, Lai J, Liu T, Matsumoto I, Barrett NA, Boyce JA, Haber AL, Bankova LGScience immunologyTuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation. Sci Immunol. 2021 Dec 24; 6(66):eabj0474.Sci Immunol2021-12-24T00:00:002021Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation.Authorship 1423176134981786Boyce JAThe Journal of clinical investigationThe role of 15 lipoxygenase 1 in asthma comes into focus. J Clin Invest. 2022 01 04; 132(1).J Clin Invest2022-01-04T00:00:002022The role of 15 lipoxygenase 1 in asthma comes into focus.35026207Cahill KN, Wu P, Milne GL, Amin T, Singer J, Murphy K, Lewis E, Gapko D, Boyce JA, Buchheit KM, Laidlaw TMThe Journal of allergy and clinical immunologyMediator production and severity of aspirin-induced respiratory reactions: Impact of sampling site and body mass index. J Allergy Clin Immunol. 2022 07; 150(1):170-177.e6.J Allergy Clin Immunol2022-01-11T00:00:002022Mediator production and severity of aspirin-induced respiratory reactions: Impact of sampling site and body mass index.Authorship 14262339NIAID20222013MERIT AwardAmerican Academy of Allergy, Asthma and Immunology2020Mentoring AwardSkidmore College2021Outstanding Service AwardAuthorship 1671625Authorship 1442308116441795Boyce J, Eccles RClinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial SurgeryDo chronic changes in nasal airflow have any physiological or pathological effect on the nose and paranasal sinuses? A systematic review. Clin Otolaryngol. 2006 Feb; 31(1):15-9.Clin Otolaryngol2006-02-01T00:00:002006Do chronic changes in nasal airflow have any physiological or pathological effect on the nose and paranasal sinuses? A systematic review.Authorship 1447013135427642Boyce JAThe Journal of allergy and clinical immunologyAdvances in mast cell biology. J Allergy Clin Immunol. 2022 06; 149(6):1919-1925.J Allergy Clin Immunol2022-04-12T00:00:002022Advances in mast cell biology.true1Research Associate in MedicineResearch Associate in MedicineAuthorship 4184677Authorship 430773236356925Foer D, Wien M, Karlson EW, Song W, Boyce JA, Brennan PJThe journal of allergy and clinical immunology. In practicePatient Characteristics Associated With Reactions to Mrgprx2-Activating Drugs in an Electronic Health Record-Linked Biobank. J Allergy Clin Immunol Pract. 2023 02; 11(2):492-499.e2.J Allergy Clin Immunol Pract2022-11-07T00:00:002022Patient Characteristics Associated With Reactions to Mrgprx2-Activating Drugs in an Electronic Health Record-Linked Biobank.Authorship 15015895Authorship 14993834Authorship 14925943Authorship 14945452Authorship 14881501Authorship 1486649236307120Nagai J, Lin J, Boyce JAJournal of immunology (Baltimore, Md. : 1950)Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and Suppresses Allergic Lung Inflammation. J Immunol. 2022 12 15; 209(12):2293-2303.J Immunol2022-12-15T00:00:002022Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and Suppresses Allergic Lung Inflammation.36205448Derakhshan T, Boyce JA, Dwyer DFThe Journal of allergy and clinical immunologyDefining mast cell differentiation and heterogeneity through single-cell transcriptomics analysis. J Allergy Clin Immunol. 2022 10; 150(4):739-747.J Allergy Clin Immunol2022-10-01T00:00:002022Defining mast cell differentiation and heterogeneity through single-cell transcriptomics analysis.36184313Laidlaw TM, Boyce JAThe Journal of allergy and clinical immunologyUpdates on immune mechanisms in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2023 02; 151(2):301-309.J Allergy Clin Immunol2022-09-30T00:00:002022Updates on immune mechanisms in aspirin-exacerbated respiratory disease.36116518Säfholm J, Abma W, Bankova LG, Boyce JA, Al-Ameri M, Orre AC, Wheelock CE, Dahlén SE, Adner MEuropean journal of pharmacologyCysteinyl-maresin 3 inhibits IL-13 induced airway hyperresponsiveness through alternative activation of the CysLT1 receptor. Eur J Pharmacol. 2022 Nov 05; 934:175257.Eur J Pharmacol2022-09-16T00:00:002022Cysteinyl-maresin 3 inhibits IL-13 induced airway hyperresponsiveness through alternative activation of the CysLT1 receptor.36196164Boyce JATransactions of the American Clinical and Climatological AssociationINSIGHTS INTO THE REGULATION OF MAST CELL FUNCTION IN TYPE 2 INFLAMMATION. Trans Am Clin Climatol Assoc. 2022; 132:92-103.Trans Am Clin Climatol Assoc2022-01-01T00:00:002022INSIGHTS INTO THE REGULATION OF MAST CELL FUNCTION IN TYPE 2 INFLAMMATION.Authorship 1514480136529561Boyce JAThe Journal of allergy and clinical immunologyReply. J Allergy Clin Immunol. 2023 03; 151(3):806.J Allergy Clin Immunol2022-12-16T00:00:002022Reply.Authorship 20862Authorship 1516074936648098Foer D, Beeler PE, Cui J, Snyder WE, Mashayekhi M, Nian H, Luther JM, Karlson EW, Boyce JA, Cahill KNClinical and experimental allergy : journal of the British Society for Allergy and Clinical ImmunologyGlucagon-like peptide-1 receptor agonist use is associated with lower serum periostin. Clin Exp Allergy. 2023 04; 53(4):469-473.Clin Exp Allergy2023-01-17T00:00:002023Glucagon-like peptide-1 receptor agonist use is associated with lower serum periostin.Authorship 2245381Authorship 15244101636804595Wang X, Hallen NR, Lee M, Samuchiwal S, Ye Q, Buchheit KM, Maxfield AZ, Roditi RE, Bergmark RW, Bhattacharyya N, Ryan T, Gakpo D, Raychaudhuri S, Dwyer D, Laidlaw TM, Boyce JA, Gutierrez-Arcelus M, Barrett NAThe Journal of allergy and clinical immunologyType 2 inflammation drives an airway basal stem cell program through insulin receptor substrate signaling. J Allergy Clin Immunol. 2023 06; 151(6):1536-1549.J Allergy Clin Immunol2023-02-17T00:00:002023Type 2 inflammation drives an airway basal stem cell program through insulin receptor substrate signaling.Authorship 1858681Authorship 15658171137068712Laidlaw TM, Buchheit KM, Cahill KN, Hacker J, Cho L, Cui J, Feng C, Chen CC, Le M, Israel E, Boyce JAThe Journal of allergy and clinical immunologyTrial of thromboxane receptor inhibition with ifetroban: TP receptors regulate eicosanoid homeostasis in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2023 09; 152(3):700-710.e3.J Allergy Clin Immunol2023-04-15T00:00:002023Trial of thromboxane receptor inhibition with ifetroban: TP receptors regulate eicosanoid homeostasis in aspirin-exacerbated respiratory disease.Authorship 30055537647574Foer D, Strasser ZH, Cui J, Cahill KN, Boyce JA, Murphy SN, Karlson EWAmerican journal of respiratory and critical care medicineAssociation of GLP-1 Receptor Agonists with Chronic Obstructive Pulmonary Disease Exacerbations among Patients with Type 2 Diabetes. Am J Respir Crit Care Med. 2023 Nov 15; 208(10):1088-1100.Am J Respir Crit Care Med2023-11-15T00:00:002023Association of GLP-1 Receptor Agonists with Chronic Obstructive Pulmonary Disease Exacerbations among Patients with Type 2 Diabetes.Authorship 159054552Professor of PediatricsProfessor of Pediatricstrue1Albert L. Sheffer Professor of Medicine in the Field of Allergic DiseaseAlbert L. Sheffer Professor of Medicine in the Field of Allergic Diseasetrue1Astrazeneca Professor of Respiratory and Inflammatory Diseases in the Department of Medicine, EmeritusAstrazeneca Professor of Respiratory and Inflammatory Diseases in the Department of Medicine, Emeritus37855723Foer D, Strasser ZH, Cui J, Cahill KN, Boyce JA, Murphy SN, Karlson EWAmerican journal of respiratory and critical care medicineReply to Li et al. Am J Respir Crit Care Med. 2023 Dec 15; 208(12):1346-1347.Am J Respir Crit Care Med2023-12-15T00:00:002023Reply to Li et al.Authorship 4352583Authorship 159882622Authorship 160289015Authorship 1601393537904989Huang GX, Hallen NR, Lee M, Zheng K, Wang X, Mandanas MV, Djeddi S, Fernandez D, Hacker J, Ryan T, Bergmark RW, Bhattacharyya N, Lee S, Maxfield AZ, Roditi RE, Buchheit KM, Laidlaw TM, Gern JE, Hallstrand TS, Ray A, Wenzel SE, Boyce JA, Gutierrez-Arcelus M, Barrett NAbioRxiv : the preprint server for biologyIncreased epithelial mTORC1 activity in chronic rhinosinusitis with nasal polyps. bioRxiv. 2023 Oct 17.bioRxiv2023-10-17T00:00:002023Increased epithelial mTORC1 activity in chronic rhinosinusitis with nasal polyps.37870292Foer D, Amin T, Nagai J, Tani Y, Feng C, Liu T, Newcomb DC, Lai J, Hayashi H, Snyder WE, McGill A, Lin A, Laidlaw TM, Niswender KD, Boyce JA, Cahill KNJournal of immunology (Baltimore, Md. : 1950)Glucagon-like Peptide-1 Receptor Pathway Attenuates Platelet Activation in Aspirin-Exacerbated Respiratory Disease. J Immunol. 2023 12 15; 211(12):1806-1813.J Immunol2023-12-15T00:00:002023Glucagon-like Peptide-1 Receptor Pathway Attenuates Platelet Activation in Aspirin-Exacerbated Respiratory Disease.Authorship 468376Authorship 5271551Authorship 16253421638306414Ualiyeva S, Lemire E, Wong C, Perniss A, Boyd AA, Avilés EC, Minichetti DG, Maxfield A, Roditi R, Matsumoto I, Wang X, Deng W, Barrett NA, Buchheit KM, Laidlaw TM, Boyce JA, Bankova LG, Haber ALScience immunologyA nasal cell atlas reveals heterogeneity of tuft cells and their role in directing olfactory stem cell proliferation. Sci Immunol. 2024 Feb 02; 9(92):eabq4341.Sci Immunol2024-02-02T00:00:002024A nasal cell atlas reveals heterogeneity of tuft cells and their role in directing olfactory stem cell proliferation.Authorship 217961Authorship 1631984838370648Djeddi S, Fernandez-Salinas D, Huang GX, Aguiar VRC, Mohanty C, Kendziorski C, Gazal S, Boyce J, Ober C, Gern J, Barrett N, Gutierrez-Arcelus MmedRxiv : the preprint server for health sciencesRhinovirus infection of airway epithelial cells uncovers the non-ciliated subset as a likely driver of genetic susceptibility to childhood-onset asthma. medRxiv. 2024 Feb 06.medRxiv2024-02-06T00:00:002024Rhinovirus infection of airway epithelial cells uncovers the non-ciliated subset as a likely driver of genetic susceptibility to childhood-onset asthma.Authorship 2336651true1Professor of Emergency MedicineProfessor of Emergency MedicineAuthorship 5516061Authorship 466182Authorship 6337251Authorship 6595872Authorship 6428732Authorship 6560044Authorship 65795413950126Boyce JA, Bernhard JDJournal of the American Academy of DermatologyTotal skin examination: patient reactions. J Am Acad Dermatol. 1986 Feb; 14(2 Pt 1):280.J Am Acad Dermatol1986-02-01T00:00:001986Total skin examination: patient reactions.23810099Barrett NA, Boyce JAThe Journal of allergy and clinical immunologyActivation of group 2 innate lymphoid cells: a new role for cysteinyl leukotrienes. J Allergy Clin Immunol. 2013 Jul; 132(1):214-6.J Allergy Clin Immunol2013-07-01T00:00:002013Activation of group 2 innate lymphoid cells: a new role for cysteinyl leukotrienes.23639708Laidlaw TM, Boyce JAImmunology and allergy clinics of North AmericaPathogenesis of aspirin-exacerbated respiratory disease and reactions. Immunol Allergy Clin North Am. 2013 May; 33(2):195-210.Immunol Allergy Clin North Am2012-12-23T00:00:002012Pathogenesis of aspirin-exacerbated respiratory disease and reactions.23586375Boyce JA, Peebles RSAmerican journal of respiratory and critical care medicineRegulation of Th9-type pulmonary immune responses: a new role for COX-2. Am J Respir Crit Care Med. 2013 Apr 15; 187(8):785-6.Am J Respir Crit Care Med2013-04-15T00:00:002013Regulation of Th9-type pulmonary immune responses: a new role for COX-2.Authorship 6770432Authorship 675197523977066Kondeti V, Duah E, Al-Azzam N, Thodeti CK, Boyce JA, Paruchuri SPloS oneDifferential regulation of cysteinyl leukotriene receptor signaling by protein kinase C in human mast cells. PLoS One. 2013; 8(8):e71536.PLoS One2013-08-15T00:00:002013Differential regulation of cysteinyl leukotriene receptor signaling by protein kinase C in human mast cells.23987187Fanning LB, Boyce JAAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & ImmunologyLipid mediators and allergic diseases. Ann Allergy Asthma Immunol. 2013 Sep; 111(3):155-62.Ann Allergy Asthma Immunol2013-07-21T00:00:002013Lipid mediators and allergic diseases.Authorship 2526028Authorship 679019424085850Liu T, Laidlaw TM, Katz HR, Boyce JAProceedings of the National Academy of Sciences of the United States of AmericaProstaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):16987-92.Proc Natl Acad Sci U S A2013-10-01T00:00:002013Prostaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes.Authorship 6923592Authorship 693199224088297Arm JP, Boyce JA, Wang L, Chhay H, Zahid M, Patil V, Govindarajulu U, Ivester P, Weaver KL, Sergeant S, Israel E, Chilton FHLipids in health and diseaseImpact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. Lipids Health Dis. 2013 Oct 02; 12:141.Lipids Health Dis2013-10-02T00:00:002013Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics.24229832Cardet JC, Boyce JAThe journal of allergy and clinical immunology. In practiceAddition of mycophenolate mofetil to tacrolimus is associated with decreases in food-specific IgE levels in a pediatric patient with liver transplantation-associated food allergy. J Allergy Clin Immunol Pract. 2013 Jan; 1(1):104-6.J Allergy Clin Immunol Pract2012-10-28T00:00:002012Addition of mycophenolate mofetil to tacrolimus is associated with decreases in food-specific IgE levels in a pediatric patient with liver transplantation-associated food allergy.Authorship 6971437Authorship 69714424244016Cummings HE, Liu T, Feng C, Laidlaw TM, Conley PB, Kanaoka Y, Boyce JAJournal of immunology (Baltimore, Md. : 1950)Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor. J Immunol. 2013 Dec 15; 191(12):5807-10.J Immunol2013-11-15T00:00:002013Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor.Laidlaw TM, Cutler A, Kidder M, Chhay H, Cardet JC, Feng C, Liu T, Boyce JAJ. Allergy Clinical ImmunologyProstaglandin E2 Resistance in Granulocytes from Patients with Aspirin Exacerbated Respiratory Disease. J. Allergy Clinical Immunology. 2014.2014-01-01T00:00:002014Prostaglandin E2 Resistance in Granulocytes from Patients with Aspirin Exacerbated Respiratory DiseaseAuthorship 2737741Authorship 804904Authorship 2658211Authorship 2661311Authorship 829143Authorship 3032452Authorship 731499824486071Laidlaw TM, Cutler AJ, Kidder MS, Liu T, Cardet JC, Chhay H, Feng C, Boyce JAThe Journal of allergy and clinical immunologyProstaglandin E2 resistance in granulocytes from patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2014 Jun; 133(6):1692-701.e3.J Allergy Clin Immunol2014-01-31T00:00:002014Prostaglandin E2 resistance in granulocytes from patients with aspirin-exacerbated respiratory disease.Authorship 1975416Authorship 740412224991451Kanaoka Y, Boyce JAAllergy, asthma & immunology researchCysteinyl leukotrienes and their receptors; emerging concepts. Allergy Asthma Immunol Res. 2014 Jul; 6(4):288-95.Allergy Asthma Immunol Res2014-05-27T00:00:002014Cysteinyl leukotrienes and their receptors; emerging concepts.DD70DanielDwyerDaniel Francis Dwyer, Ph.D.78656Dwyer, DanielAssistant Professor of MedicineAuthorship 3674388Authorship 3786169Authorship 381052525218285Cahill KN, Bensko JC, Boyce JA, Laidlaw TMThe Journal of allergy and clinical immunologyProstaglandin D2: a dominant mediator of aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2015 Jan; 135(1):245-52.J Allergy Clin Immunol2014-09-11T00:00:002014Prostaglandin D2: a dominant mediator of aspirin-exacerbated respiratory disease.Authorship 4030837Authorship 4133152Authorship 429393Authorship 4410795Emergency Medicine25485197Kazani S, Arm JP, Boyce J, Chhay H, Dutile S, Wechsler ME, Govindarajulu U, Ivester P, Ainsworth HC, Sergeant S, Chilton FH, Israel ESpringerPlusLTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma. Springerplus. 2014; 3:661.Springerplus2014-11-06T00:00:002014LTC4 synthase polymorphism modifies efficacy of botanical seed oil combination in asthma.Authorship 7775633Authorship 5266922Authorship 5104095Authorship 5616651Authorship 4802342Authorship 477027Authorship 1721494Authorship 5755716Authorship 2783665Authorship 2805346Authorship 635763Authorship 6471Authorship 194012Authorship 4342602Authorship 5674565Authorship 2671191Authorship 39980310Authorship 505803126051534Cahill KN, Raby BA, Zhou X, Guo F, Thibault D, Baccarelli A, Byun HM, Bhattacharyya N, Steinke JW, Boyce JA, Laidlaw TMAmerican journal of respiratory cell and molecular biologyImpaired E Prostanoid2 Expression and Resistance to Prostaglandin E2 in Nasal Polyp Fibroblasts from Subjects with Aspirin-Exacerbated Respiratory Disease. Am J Respir Cell Mol Biol. 2016 Jan; 54(1):34-40.Am J Respir Cell Mol Biol2016-01-01T00:00:002016Impaired E Prostanoid2 Expression and Resistance to Prostaglandin E2 in Nasal Polyp Fibroblasts from Subjects with Aspirin-Exacerbated Respiratory Disease.Authorship 2546262Authorship 37659011Authorship 3914181Authorship 4422422Authorship 4485965Authorship 5009602Authorship 8017481Authorship 803908725904552Liu T, Garofalo D, Feng C, Lai J, Katz H, Laidlaw TM, Boyce JAJournal of immunology (Baltimore, Md. : 1950)Platelet-driven leukotriene C4-mediated airway inflammation in mice is aspirin-sensitive and depends on T prostanoid receptors. J Immunol. 2015 Jun 01; 194(11):5061-8.J Immunol2015-04-22T00:00:002015Platelet-driven leukotriene C4-mediated airway inflammation in mice is aspirin-sensitive and depends on T prostanoid receptors.25723820Boyce JA, Barrett NAAmerican journal of respiratory and critical care medicineCysteinyl leukotrienes: an innate system for epithelial control of airway smooth muscle proliferation? Am J Respir Crit Care Med. 2015 Mar 01; 191(5):496-7.Am J Respir Crit Care Med2015-03-01T00:00:002015Cysteinyl leukotrienes: an innate system for epithelial control of airway smooth muscle proliferation?Authorship 4687655Authorship 4892202Authorship 37150210Authorship 4140762Authorship 3425412Authorship 36138Authorship 8213433Authorship 822230226051947Laidlaw TM, Boyce JAThe Journal of allergy and clinical immunologyPlatelets in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2015 Jun; 135(6):1407-14; quiz 1415.J Allergy Clin Immunol2015-06-01T00:00:002015Platelets in patients with aspirin-exacerbated respiratory disease.Authorship 4375221Authorship 4741729Authorship 8381991126342029Liu T, Kanaoka Y, Barrett NA, Feng C, Garofalo D, Lai J, Buchheit K, Bhattacharya N, Laidlaw TM, Katz HR, Boyce JAJournal of immunology (Baltimore, Md. : 1950)Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway. J Immunol. 2015 Oct 15; 195(8):3537-45.J Immunol2015-09-04T00:00:002015Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway.Authorship 420541Authorship 85550110Authorship 4692525Authorship 860484526255103Kondeti V, Al-Azzam N, Duah E, Thodeti CK, Boyce JA, Paruchuri SThe Journal of allergy and clinical immunologyLeukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3. J Allergy Clin Immunol. 2016 Jan; 137(1):289-298.J Allergy Clin Immunol2015-08-05T00:00:002015Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3.Authorship 865431226840139Laidlaw TM, Boyce JAThe New England journal of medicineAspirin-Exacerbated Respiratory Disease--New Prime Suspects. N Engl J Med. 2016 Feb 04; 374(5):484-8.N Engl J Med2016-02-04T00:00:002016Aspirin-Exacerbated Respiratory Disease--New Prime Suspects.Authorship 3212363Authorship 3999469Authorship 4105036Authorship 8814451026691435Buchheit KM, Cahill KN, Katz HR, Murphy KC, Feng C, Lee-Sarwar K, Lai J, Bhattacharyya N, Israel E, Boyce JA, Laidlaw TMThe Journal of allergy and clinical immunologyThymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2016 05; 137(5):1566-1576.e5.J Allergy Clin Immunol2015-12-12T00:00:002015Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease.Authorship 884289427185938Bankova LG, Lai J, Yoshimoto E, Boyce JA, Austen KF, Kanaoka Y, Barrett NAProceedings of the National Academy of Sciences of the United States of AmericaLeukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6242-7.Proc Natl Acad Sci U S A2016-05-16T00:00:002016Leukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99.Authorship 5601422Authorship 740147Authorship 7638462Assistant Professor1Associate Professor0Full Professor4Instructor5Other FacultyAuthorship 488639102022-12-31BOYCE, JOSHUA A2002-08-01CysLT and P2Y Receptors in Lung InflammationR37AI0523532024-07-31BOYCE, JOSHUA A1985-07-01Immunologic Basis of Resistance and HypersensitivityT32AI0073062011-05-31BOYCE, JOSHUA A1985-09-01Chemical Mediators of Acute Pulmonary DisordersP01HL0361102008-01-14BOYCE, JOSHUA A2002-08-01CysLt and P2Y Receptors and Lung InflammationR56AI0523532008-02-29AUSTEN, KARL FRANK1991-09-01Cellular Basis of Hypersensitivity Diseases in HumansP01AI0315992017-04-30BOYCE, JOSHUA A2013-06-15Eicosanoid Networks in Aspirin Exacerbated Respiratory DiseaseR01HL1179452026-07-31BOYCE, JOSHUA A2008-04-01Control of Pulmonary Inflammation by Leukotriene E4R01AI0789082012-12-31BOYCE, JOSHUA A2002-08-01CysLT and P2Y Receptors in Lung InflammationR01AI0523532011-07-31BOYCE, JOSHUA A2009-08-01Lipidomic and Transcriptome Signatures in Aspirin-Exacerbated Respiratory DiseaseR21AI0823692001-03-31BOYCE, JOSHUA A1996-04-01FUNCTION OF IMMATURE HYPODENSE HUMAN EOSINOPHILSK11AI0013042008-04-30BOYCE, JOSHUA A2002-05-01The Role of Mast Cells in Lung InflammationR01AI0488022015-11-30ISRAEL, ELLIOT2010-06-01Kit Inhibition in Asthma (KIA)U01HL1022252026-04-30BOYCE, JOSHUA A2011-07-15Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory DiseaseU19AI095219Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorAuthorship 3777438Authorship 927619227771324Cahill KN, Boyce JAThe Journal of allergy and clinical immunologyAspirin-exacerbated respiratory disease: Mediators and mechanisms of a clinical disease. J Allergy Clin Immunol. 2017 03; 139(3):764-766.J Allergy Clin Immunol2016-10-19T00:00:002016Aspirin-exacerbated respiratory disease: Mediators and mechanisms of a clinical disease.Authorship 65908Authorship 94738830Authorship 9472973028054723Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JAPediatric dermatologyAddendum Guidelines for the Prevention of Peanut Allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-Sponsored Expert Panel. Pediatr Dermatol. 2017 Jan; 34(1):e1-e21.Pediatr Dermatol2017-01-01T00:00:002017Addendum Guidelines for the Prevention of Peanut Allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-Sponsored Expert Panel.28054718Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JAPediatric dermatologyAddendum guidelines for the prevention of peanut allergy in the United States: Summary of the National Institute of Allergy and Infectious Diseases-sponsored expert panel. Pediatr Dermatol. 2017 Jan; 34(1):5-12.Pediatr Dermatol2017-01-01T00:00:002017Addendum guidelines for the prevention of peanut allergy in the United States: Summary of the National Institute of Allergy and Infectious Diseases-sponsored expert panel.Authorship 94894230Authorship 9489053028065278Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JAThe Journal of allergy and clinical immunologyAddendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel. J Allergy Clin Immunol. 2017 Jan; 139(1):29-44.J Allergy Clin Immunol2017-01-01T00:00:002017Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel.28065802Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JAAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & ImmunologyAddendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel. Ann Allergy Asthma Immunol. 2017 02; 118(2):166-173.e7.Ann Allergy Asthma Immunol2017-01-05T00:00:002017Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel.Authorship 95586130Authorship 9535483028151739Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JAJAAPA : official journal of the American Academy of Physician AssistantsAddendum guidelines for the prevention of peanut allergy in the United States. JAAPA. 2017 Mar; 30(3):1-5.JAAPA2017-03-01T00:00:002017Addendum guidelines for the prevention of peanut allergy in the United States.28137368Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JAJournal of pediatric nursingAddendum Guidelines for the Prevention of Peanut Allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-Sponsored Expert Panel. J Pediatr Nurs. 2017 Jan - Feb; 32:91-98.J Pediatr Nurs2017-01-01T00:00:002017Addendum Guidelines for the Prevention of Peanut Allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-Sponsored Expert Panel.Authorship 902444Skidmore College1981Dowd-Lester AwardUniversity of Massachusetts2012Alpha Omega Alpha (Alumini Member)American Academy of Allergy Asthma and Immunology2012AAAAI Special Recognition AwardNIH/NIAID20001995Physician-Scientist Award (K08)Skidmore College1981Charlotte Fahey Award11231354Hou FF, Miyata T, Boyce J, Yuan Q, Chertow GM, Kay J, Schmidt AM, Owen WFKidney internationalbeta(2)-Microglobulin modified with advanced glycation end products delays monocyte apoptosis. Kidney Int. 2001 Mar; 59(3):990-1002.Kidney Int2001-03-01T00:00:002001beta(2)-Microglobulin modified with advanced glycation end products delays monocyte apoptosis.11975418Gurish MF, Boyce JAClinical reviews in allergy & immunologyMast cell growth, differentiation, and death. Clin Rev Allergy Immunol. 2002 Apr; 22(2):107-18.Clin Rev Allergy Immunol2002-04-01T00:00:002002Mast cell growth, differentiation, and death.11254538Silverman ES, De Sanctis GT, Boyce J, Maclean JA, Jiao A, Green FH, Grasemann H, Faunce D, Fitzmaurice G, Shi GP, Stein-Streilein J, Milbrandt J, Collins T, Drazen JMAmerican journal of respiratory and critical care medicineThe transcription factor early growth-response factor 1 modulates tumor necrosis factor-alpha, immunoglobulin E, and airway responsiveness in mice. Am J Respir Crit Care Med. 2001 Mar; 163(3 Pt 1):778-85.Am J Respir Crit Care Med2001-03-01T00:00:002001The transcription factor early growth-response factor 1 modulates tumor necrosis factor-alpha, immunoglobulin E, and airway responsiveness in mice.9150467Hou FF, Chertow GM, Kay J, Boyce J, Lazarus JM, Braatz JA, Owen WFKidney internationalInteraction between beta 2-microglobulin and advanced glycation end products in the development of dialysis related-amyloidosis. Kidney Int. 1997 May; 51(5):1514-9.Kidney Int1997-05-01T00:00:001997Interaction between beta 2-microglobulin and advanced glycation end products in the development of dialysis related-amyloidosis.18411276Paruchuri S, Jiang Y, Feng C, Francis SA, Plutzky J, Boyce JAThe Journal of biological chemistryLeukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells. J Biol Chem. 2008 Jun 13; 283(24):16477-87.J Biol Chem2008-04-14T00:00:002008Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells.Authorship 973077428341741Samuchiwal SK, Balestrieri B, Raff H, Boyce JAThe Journal of biological chemistryEndogenous prostaglandin E2 amplifies IL-33 production by macrophages through an E prostanoid (EP)2/EP4-cAMP-EPAC-dependent pathway. J Biol Chem. 2017 05 19; 292(20):8195-8206.J Biol Chem2017-03-24T00:00:002017Endogenous prostaglandin E2 amplifies IL-33 production by macrophages through an E prostanoid (EP)2/EP4-cAMP-EPAC-dependent pathway.9221761Yuan Q, Austen KF, Friend DS, Heidtman M, Boyce JAThe Journal of experimental medicineHuman peripheral blood eosinophils express a functional c-kit receptor for stem cell factor that stimulates very late antigen 4 (VLA-4)-mediated cell adhesion to fibronectin and vascular cell adhesion molecule 1 (VCAM-1). J Exp Med. 1997 Jul 21; 186(2):313-23.J Exp Med1997-07-21T00:00:001997Human peripheral blood eosinophils express a functional c-kit receptor for stem cell factor that stimulates very late antigen 4 (VLA-4)-mediated cell adhesion to fibronectin and vascular cell adhesion molecule 1 (VCAM-1).14763243Lin DA, Boyce JAAllergy and asthma proceedingsThe idiopathic hypereosinophilic syndrome. Allergy Asthma Proc. 2003 Nov-Dec; 24(6):417-20.Allergy Asthma Proc2003-11-01T00:00:002003The idiopathic hypereosinophilic syndrome.16920908Jiang Y, Kanaoka Y, Feng C, Nocka K, Rao S, Boyce JAJournal of immunology (Baltimore, Md. : 1950)Cutting edge: Interleukin 4-dependent mast cell proliferation requires autocrine/intracrine cysteinyl leukotriene-induced signaling. J Immunol. 2006 Sep 01; 177(5):2755-9.J Immunol2006-09-01T00:00:002006Cutting edge: Interleukin 4-dependent mast cell proliferation requires autocrine/intracrine cysteinyl leukotriene-induced signaling.11438743Mellor EA, Maekawa A, Austen KF, Boyce JAProceedings of the National Academy of Sciences of the United States of AmericaCysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells. Proc Natl Acad Sci U S A. 2001 Jul 03; 98(14):7964-9.Proc Natl Acad Sci U S A2001-07-03T00:00:002001Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells.11602722Bannert N, Farzan M, Friend DS, Ochi H, Price KS, Sodroski J, Boyce JAJournal of virologyHuman Mast cell progenitors can be infected by macrophagetropic human immunodeficiency virus type 1 and retain virus with maturation in vitro. J Virol. 2001 Nov; 75(22):10808-14.J Virol2001-11-01T00:00:002001Human Mast cell progenitors can be infected by macrophagetropic human immunodeficiency virus type 1 and retain virus with maturation in vitro.Authorship 9816991728514613Cahill KN, Katz HR, Cui J, Lai J, Kazani S, Crosby-Thompson A, Garofalo D, Castro M, Jarjour N, DiMango E, Erzurum S, Trevor JL, Shenoy K, Chinchilli VM, Wechsler ME, Laidlaw TM, Boyce JA, Israel EThe New England journal of medicineKIT Inhibition by Imatinib in Patients with Severe Refractory Asthma. N Engl J Med. 2017 05 18; 376(20):1911-1920.N Engl J Med2017-05-18T00:00:002017KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma.12194977Wong GW, Foster PS, Yasuda S, Qi JC, Mahalingam S, Mellor EA, Katsoulotos G, Li L, Boyce JA, Krilis SA, Stevens RLThe Journal of biological chemistryBiochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal transducer and activator of transcription (STAT) 6-dependent pathway. J Biol Chem. 2002 Nov 01; 277(44):41906-15.J Biol Chem2002-08-22T00:00:002002Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal transducer and activator of transcription (STAT) 6-dependent pathway.11136826Hsieh FH, Lam BK, Penrose JF, Austen KF, Boyce JAThe Journal of experimental medicineT helper cell type 2 cytokines coordinately regulate immunoglobulin E-dependent cysteinyl leukotriene production by human cord blood-derived mast cells: profound induction of leukotriene C(4) synthase expression by interleukin 4. J Exp Med. 2001 Jan 01; 193(1):123-33.J Exp Med2001-01-01T00:00:002001T helper cell type 2 cytokines coordinately regulate immunoglobulin E-dependent cysteinyl leukotriene production by human cord blood-derived mast cells: profound induction of leukotriene C(4) synthase expression by interleukin 4.21215925Boyce JA, Assa'a A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, Bahna SL, Beck LA, Byrd-Bredbenner C, Camargo CA, Eichenfield L, Furuta GT, Hanifin JM, Jones C, Kraft M, Levy BD, Lieberman P, Luccioli S, McCall KM, Schneider LC, Simon RA, Simons FE, Teach SJ, Yawn BP, Schwaninger JMNutrition (Burbank, Los Angeles County, Calif.)Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-Sponsored Expert Panel Report. Nutrition. 2011 Feb; 27(2):253-67.Nutrition2011-02-01T00:00:002011Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-Sponsored Expert Panel Report.21464938Lundequist A, Boyce JAPloS oneLPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1ß release. PLoS One. 2011 Mar 28; 6(3):e18192.PLoS One2011-03-28T00:00:002011LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1ß release.14657870Lora JM, Al-Garawi A, Pickard MD, Price KS, Bagga S, Sicoli J, Hodge MR, Gutiérrez-Ramos JC, Briskin MJ, Boyce JAThe Journal of allergy and clinical immunologyFcepsilonRI-dependent gene expression in human mast cells is differentially controlled by T helper type 2 cytokines. J Allergy Clin Immunol. 2003 Dec; 112(6):1119-26.J Allergy Clin Immunol2003-12-01T00:00:002003FcepsilonRI-dependent gene expression in human mast cells is differentially controlled by T helper type 2 cytokines.15319282Bagga S, Price KS, Lin DA, Friend DS, Austen KF, Boyce JABloodLysophosphatidic acid accelerates the development of human mast cells. Blood. 2004 Dec 15; 104(13):4080-7.Blood2004-08-19T00:00:002004Lysophosphatidic acid accelerates the development of human mast cells.16107763Boyce JAChemical immunology and allergyEicosanoid mediators of mast cells: receptors, regulation of synthesis, and pathobiologic implications. Chem Immunol Allergy. 2005; 87:59-79.Chem Immunol Allergy2005-01-01T00:00:002005Eicosanoid mediators of mast cells: receptors, regulation of synthesis, and pathobiologic implications.17693579Jiang Y, Borrelli LA, Kanaoka Y, Bacskai BJ, Boyce JABloodCysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. Blood. 2007 Nov 01; 110(9):3263-70.Blood2007-08-10T00:00:002007CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells.13679572Mellor EA, Frank N, Soler D, Hodge MR, Lora JM, Austen KF, Boyce JAProceedings of the National Academy of Sciences of the United States of AmericaExpression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11589-93.Proc Natl Acad Sci U S A2003-09-17T00:00:002003Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R.15265876Kanaoka Y, Boyce JAJournal of immunology (Baltimore, Md. : 1950)Cysteinyl leukotrienes and their receptors: cellular distribution and function in immune and inflammatory responses. J Immunol. 2004 Aug 01; 173(3):1503-10.J Immunol2004-08-01T00:00:002004Cysteinyl leukotrienes and their receptors: cellular distribution and function in immune and inflammatory responses.9441233Castells M, Boyce JThe New England journal of medicineTransfer of peanut allergy by a liver allograft. N Engl J Med. 1998 Jan 15; 338(3):202-3.N Engl J Med1998-01-15T00:00:001998Transfer of peanut allergy by a liver allograft.21281958Laidlaw TM, Steinke JW, Tiñana AM, Feng C, Xing W, Lam BK, Paruchuri S, Boyce JA, Borish LThe Journal of allergy and clinical immunologyCharacterization of a novel human mast cell line that responds to stem cell factor and expresses functional FceRI. J Allergy Clin Immunol. 2011 Mar; 127(3):815-22.e1-5.J Allergy Clin Immunol2011-02-01T00:00:002011Characterization of a novel human mast cell line that responds to stem cell factor and expresses functional FceRI.16210650Lin DA, Boyce JAJournal of immunology (Baltimore, Md. : 1950)IL-4 regulates MEK expression required for lysophosphatidic acid-mediated chemokine generation by human mast cells. J Immunol. 2005 Oct 15; 175(8):5430-8.J Immunol2005-10-15T00:00:002005IL-4 regulates MEK expression required for lysophosphatidic acid-mediated chemokine generation by human mast cells.17641040Gonzalo JA, Qiu Y, Lora JM, Al-Garawi A, Villeval JL, Boyce JA, Martinez-A C, Marquez G, Goya I, Hamid Q, Fraser CC, Picarella D, Cote-Sierra J, Hodge MR, Gutierrez-Ramos JC, Kolbeck R, Coyle AJJournal of immunology (Baltimore, Md. : 1950)Coordinated involvement of mast cells and T cells in allergic mucosal inflammation: critical role of the CC chemokine ligand 1:CCR8 axis. J Immunol. 2007 Aug 01; 179(3):1740-50.J Immunol2007-08-01T00:00:002007Coordinated involvement of mast cells and T cells in allergic mucosal inflammation: critical role of the CC chemokine ligand 1:CCR8 axis.Principal Investigator16751006Boyce JAThe Journal of allergy and clinical immunologySuccessful treatment of cold-induced urticaria/anaphylaxis with anti-IgE. J Allergy Clin Immunol. 2006 Jun; 117(6):1415-8.J Allergy Clin Immunol2006-05-11T00:00:002006Successful treatment of cold-induced urticaria/anaphylaxis with anti-IgE.16950274Boyce JAThe Journal of allergy and clinical immunologyAsthma 2005-2006: bench to bedside. J Allergy Clin Immunol. 2006 Sep; 118(3):582-6.J Allergy Clin Immunol2006-09-01T00:00:002006Asthma 2005-2006: bench to bedside.2016-11-30BOYCE, JOSHUA A2014-12-05Characterization of a Novel Growth and Survival Factor for Human Mast CellsR21AI11513722802632Liu T, Laidlaw TM, Feng C, Xing W, Shen S, Milne GL, Boyce JAProceedings of the National Academy of Sciences of the United States of AmericaProstaglandin E2 deficiency uncovers a dominant role for thromboxane A2 in house dust mite-induced allergic pulmonary inflammation. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12692-7.Proc Natl Acad Sci U S A2012-07-16T00:00:002012Prostaglandin E2 deficiency uncovers a dominant role for thromboxane A2 in house dust mite-induced allergic pulmonary inflammation.10849108Hou FF, Boyce J, Zhang Y, Owen WFImmunology and cell biologyPhenotypic and functional characteristics of macrophage-like cells differentiated in pro-inflammatory cytokine-containing cultures. Immunol Cell Biol. 2000 Jun; 78(3):205-13.Immunol Cell Biol2000-06-01T00:00:002000Phenotypic and functional characteristics of macrophage-like cells differentiated in pro-inflammatory cytokine-containing cultures.20817863Giannattasio G, Fujioka D, Xing W, Katz HR, Boyce JA, Balestrieri BJournal of immunology (Baltimore, Md. : 1950)Group V secretory phospholipase A2 reveals its role in house dust mite-induced allergic pulmonary inflammation by regulation of dendritic cell function. J Immunol. 2010 Oct 01; 185(7):4430-8.J Immunol2010-09-03T00:00:002010Group V secretory phospholipase A2 reveals its role in house dust mite-induced allergic pulmonary inflammation by regulation of dendritic cell function.22925317Laidlaw TM, Boyce JAClinical and experimental allergy : journal of the British Society for Allergy and Clinical ImmunologyCysteinyl leukotriene receptors, old and new; implications for asthma. Clin Exp Allergy. 2012 Sep; 42(9):1313-20.Clin Exp Allergy2012-09-01T00:00:002012Cysteinyl leukotriene receptors, old and new; implications for asthma.23352632Bochner BS, Rothenberg ME, Boyce JA, Finkelman FThe Journal of allergy and clinical immunologyAdvances in mechanisms of allergy and clinical immunology in 2012. J Allergy Clin Immunol. 2013 Mar; 131(3):661-7.J Allergy Clin Immunol2013-01-23T00:00:002013Advances in mechanisms of allergy and clinical immunology in 2012.Authorship 1006419228813135Cahill KN, Boyce JA, Israel EThe New England journal of medicineNovel Treatments for Airway Disease. N Engl J Med. 2017 08 10; 377(6):597.N Engl J Med2017-08-10T00:00:002017Novel Treatments for Airway Disease.21134576Boyce JA, Assa'ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, Bahna SL, Beck LA, Byrd-Bredbenner C, Camargo CA, Eichenfield L, Furuta GT, Hanifin JM, Jones C, Kraft M, Levy BD, Lieberman P, Luccioli S, McCall KM, Schneider LC, Simon RA, Simons FE, Teach SJ, Yawn BP, Schwaninger JMThe Journal of allergy and clinical immunologyGuidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol. 2010 Dec; 126(6 Suppl):S1-58.J Allergy Clin Immunol2010-12-01T00:00:002010Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel.2021-01-31PENN, RAYMOND B.2017-02-01Optimizing EP receptor subtype targeting for asthma therapyR01HL136209Co-Principal Investigator21724990Giannattasio G, Ohta S, Boyce JR, Xing W, Balestrieri B, Boyce JAJournal of immunology (Baltimore, Md. : 1950)The purinergic G protein-coupled receptor 6 inhibits effector T cell activation in allergic pulmonary inflammation. J Immunol. 2011 Aug 01; 187(3):1486-95.J Immunol2011-07-01T00:00:002011The purinergic G protein-coupled receptor 6 inhibits effector T cell activation in allergic pulmonary inflammation.12528608Beller TC, Boyce JAAllergy and asthma proceedingsProlonged anticonvulsant hypersensitivity syndrome related to lamotrigine in a patient with human immunodeficiency virus. Allergy Asthma Proc. 2002 Nov-Dec; 23(6):415-9.Allergy Asthma Proc2002-11-01T00:00:002002Prolonged anticonvulsant hypersensitivity syndrome related to lamotrigine in a patient with human immunodeficiency virus.12654630Price KS, Friend DS, Mellor EA, De Jesus N, Watts GF, Boyce JAAmerican journal of respiratory cell and molecular biologyCC chemokine receptor 3 mobilizes to the surface of human mast cells and potentiates immunoglobulin E-dependent generation of interleukin 13. Am J Respir Cell Mol Biol. 2003 Apr; 28(4):420-7.Am J Respir Cell Mol Biol2003-04-01T00:00:002003CC chemokine receptor 3 mobilizes to the surface of human mast cells and potentiates immunoglobulin E-dependent generation of interleukin 13.14699394Garrett JK, Jameson SC, Thomson B, Collins MH, Wagoner LE, Freese DK, Beck LA, Boyce JA, Filipovich AH, Villanueva JM, Sutton SA, Assa'ad AH, Rothenberg METhe Journal of allergy and clinical immunologyAnti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J Allergy Clin Immunol. 2004 Jan; 113(1):115-9.J Allergy Clin Immunol2003-12-12T00:00:002003Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes.15967817Boyce JA, Austen KFThe Journal of experimental medicineNo audible wheezing: nuggets and conundrums from mouse asthma models. J Exp Med. 2005 Jun 20; 201(12):1869-73.J Exp Med2005-06-20T00:00:002005No audible wheezing: nuggets and conundrums from mouse asthma models.20363972Simarro M, Giannattasio G, De la Fuente MA, Benarafa C, Subramanian KK, Ishizawar R, Balestrieri B, Andersson EM, Luo HR, Orduña A, Boyce J, Anderson PJournal of immunology (Baltimore, Md. : 1950)Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation. J Immunol. 2010 May 01; 184(9):5325-32.J Immunol2010-04-02T00:00:002010Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation.21134568Boyce JA, Assa'ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, Bahna SL, Beck LA, Byrd-Bredbenner C, Camargo CA, Eichenfield L, Furuta GT, Hanifin JM, Jones C, Kraft M, Levy BD, Lieberman P, Luccioli S, McCall KM, Schneider LC, Simon RA, Simons FE, Teach SJ, Yawn BP, Schwaninger JMThe Journal of allergy and clinical immunologyGuidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report. J Allergy Clin Immunol. 2010 12; 126(6):1105-18.J Allergy Clin Immunol2010-12-01T00:00:002010Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report.22262771Laidlaw TM, Kidder MS, Bhattacharyya N, Xing W, Shen S, Milne GL, Castells MC, Chhay H, Boyce JABloodCysteinyl leukotriene overproduction in aspirin-exacerbated respiratory disease is driven by platelet-adherent leukocytes. Blood. 2012 Apr 19; 119(16):3790-8.Blood2012-01-18T00:00:002012Cysteinyl leukotriene overproduction in aspirin-exacerbated respiratory disease is driven by platelet-adherent leukocytes.9573554Owen WF, Hou FF, Stuart RO, Kay J, Boyce J, Chertow GM, Schmidt AMKidney internationalBeta 2-microglobulin modified with advanced glycation end products modulates collagen synthesis by human fibroblasts. Kidney Int. 1998 May; 53(5):1365-73.Kidney Int1998-05-01T00:00:001998Beta 2-microglobulin modified with advanced glycation end products modulates collagen synthesis by human fibroblasts.8637892Boyce JA, Friend D, Gurish MF, Austen KF, Owen WFProceedings of the National Academy of Sciences of the United States of AmericaConstitutive production of granulocyte/macrophage colony-stimulating factor by hypodense mononuclear eosinophils developed in vitro from hybrid eosinophil/basophil granulocytes. Proc Natl Acad Sci U S A. 1996 Mar 19; 93(6):2436-41.Proc Natl Acad Sci U S A1996-03-19T00:00:001996Constitutive production of granulocyte/macrophage colony-stimulating factor by hypodense mononuclear eosinophils developed in vitro from hybrid eosinophil/basophil granulocytes.21310308Boyce JA, Assa'ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, Bahna SL, Beck LA, Byrd-Bredbenner C, Camargo CA, Eichenfield L, Furuta GT, Hanifin JM, Jones C, Kraft M, Levy BD, Lieberman P, Luccioli S, McCall KM, Schneider LC, Simon RA, Simons FE, Teach SJ, Yawn BP, Schwaninger JMNutrition research (New York, N.Y.)Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report. Nutr Res. 2011 Jan; 31(1):61-75.Nutr Res2011-01-01T00:00:002011Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report.22525013Simarro M, Giannattasio G, Xing W, Lundequist EM, Stewart S, Stevens RL, Orduña A, Boyce JA, Anderson PJImmunology lettersThe translational repressor T-cell intracellular antigen-1 (TIA-1) is a key modulator of Th2 and Th17 responses driving pulmonary inflammation induced by exposure to house dust mite. Immunol Lett. 2012 Aug 30; 146(1-2):8-14.Immunol Lett2012-04-15T00:00:002012The translational repressor T-cell intracellular antigen-1 (TIA-1) is a key modulator of Th2 and Th17 responses driving pulmonary inflammation induced by exposure to house dust mite.75 Francis StBrigham and Women's HospitalSmith Bldg, Rm 61875 Francis StBoston02115MA11877481Mellor EA, Austen KF, Boyce JAThe Journal of experimental medicineCysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists. J Exp Med. 2002 Mar 04; 195(5):583-92.J Exp Med2002-03-04T00:00:002002Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists.16670268Abonia JP, Hallgren J, Jones T, Shi T, Xu Y, Koni P, Flavell RA, Boyce JA, Austen KF, Gurish MFBloodAlpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung. Blood. 2006 Sep 01; 108(5):1588-94.Blood2006-05-02T00:00:002006Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung.2022-11-30BOYCE, JOSHUA A2017-12-04Eicosanoid Networks in Aspirin HypersensitivityR01AI136041Principal Investigator20028661Lundequist A, Nallamshetty SN, Xing W, Feng C, Laidlaw TM, Uematsu S, Akira S, Boyce JAJournal of immunology (Baltimore, Md. : 1950)Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation. J Immunol. 2010 Jan 01; 184(1):433-41.J Immunol2010-01-01T00:00:002010Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation.Authorship 1035702829282304Liu T, Barrett NA, Kanaoka Y, Yoshimoto E, Garofalo D, Cirka H, Feng C, Boyce JAJournal of immunology (Baltimore, Md. : 1950)Type 2 Cysteinyl Leukotriene Receptors Drive IL-33-Dependent Type 2 Immunopathology and Aspirin Sensitivity. J Immunol. 2018 02 01; 200(3):915-927.J Immunol2017-12-27T00:00:002017Type 2 Cysteinyl Leukotriene Receptors Drive IL-33-Dependent Type 2 Immunopathology and Aspirin Sensitivity.Authorship 1038367429346348Yamaguchi M, Samuchiwal SK, Quehenberger O, Boyce JA, Balestrieri BMucosal immunologyMacrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms. Mucosal Immunol. 2018 05; 11(3):615-626.Mucosal Immunol2017-12-20T00:00:002017Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms.18691060Boyce JACurrent molecular medicineEicosanoids in asthma, allergic inflammation, and host defense. Curr Mol Med. 2008 Aug; 8(5):335-49.Curr Mol Med2008-08-01T00:00:002008Eicosanoids in asthma, allergic inflammation, and host defense.9527404Hou FF, Boyce J, Chertow GM, Kay J, Owen WFJournal of the American Society of Nephrology : JASNAminoguanidine inhibits advanced glycation end products formation on beta2-microglobulin. J Am Soc Nephrol. 1998 Feb; 9(2):277-83.J Am Soc Nephrol1998-02-01T00:00:001998Aminoguanidine inhibits advanced glycation end products formation on beta2-microglobulin.Authorship 105347515055558Boyce JAAllergy and asthma proceedingsThe biology of the mast cell. Allergy Asthma Proc. 2004 Jan-Feb; 25(1):27-30.Allergy Asthma Proc2004-01-01T00:00:002004The biology of the mast cell.16750988Gurish MF, Boyce JAThe Journal of allergy and clinical immunologyMast cells: ontogeny, homing, and recruitment of a unique innate effector cell. J Allergy Clin Immunol. 2006 Jun; 117(6):1285-91.J Allergy Clin Immunol2006-06-01T00:00:002006Mast cells: ontogeny, homing, and recruitment of a unique innate effector cell.16788002Tournilhac O, Santos DD, Xu L, Kutok J, Tai YT, Le Gouill S, Catley L, Hunter Z, Branagan AR, Boyce JA, Munshi N, Anderson KC, Treon SPAnnals of oncology : official journal of the European Society for Medical OncologyMast cells in Waldenstrom's macroglobulinemia support lymphoplasmacytic cell growth through CD154/CD40 signaling. Ann Oncol. 2006 Aug; 17(8):1275-82.Ann Oncol2006-06-20T00:00:002006Mast cells in Waldenstrom's macroglobulinemia support lymphoplasmacytic cell growth through CD154/CD40 signaling.9337423Boyce JAAllergy and asthma proceedingsThe pathobiology of eosinophilic inflammation. Allergy Asthma Proc. 1997 Sep-Oct; 18(5):293-300.Allergy Asthma Proc1997-09-01T00:00:001997The pathobiology of eosinophilic inflammation.10432289Ochi H, Hirani WM, Yuan Q, Friend DS, Austen KF, Boyce JAThe Journal of experimental medicineT helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro. J Exp Med. 1999 Jul 19; 190(2):267-80.J Exp Med1999-07-19T00:00:001999T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro.11377675Austen KF, Boyce JALeukemia researchMast cell lineage development and phenotypic regulation. Leuk Res. 2001 Jul; 25(7):511-8.Leuk Res2001-07-01T00:00:002001Mast cell lineage development and phenotypic regulation.