KS26KevinStruhlKevin Struhl, Ph.D.42.33588600000000-71.1051460000000013584Struhl, Kevin617/432-2104David Wesley Gaiser Professor of Biological Chemistry and Molecular Pharmacologycatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson11333220Lee M, Struhl KGeneticsMultiple functions of the nonconserved N-terminal domain of yeast TATA-binding protein. Genetics. 2001 May; 158(1):87-93.Genetics2001-05-01T00:00:002001Multiple functions of the nonconserved N-terminal domain of yeast TATA-binding protein.1586947Cormack BP, Struhl KCellThe TATA-binding protein is required for transcription by all three nuclear RNA polymerases in yeast cells. Cell. 1992 May 15; 69(4):685-96.Cell1992-05-15T00:00:001992The TATA-binding protein is required for transcription by all three nuclear RNA polymerases in yeast cells.11937489Ng HH, Robert F, Young RA, Struhl KGenes & developmentGenome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex. Genes Dev. 2002 Apr 01; 16(7):806-19.Genes Dev2002-04-01T00:00:002002Genome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex.6246242Struhl K, Davis RWJournal of molecular biologyA physical, genetic and transcriptional map of the cloned his3 gene region of Saccharomyces cerevisiae. J Mol Biol. 1980 Jan 25; 136(3):309-32.J Mol Biol1980-01-25T00:00:001980A physical, genetic and transcriptional map of the cloned his3 gene region of Saccharomyces cerevisiae.6449602Struhl K, Davis RWJournal of molecular biologyConservation and DNA sequence arrangement of the DNA polymerase I gene region from Klebsiella aerogenes, Klebsiella pneumoniae and Escherichia coli. J Mol Biol. 1980 Aug 25; 141(4):343-68.J Mol Biol1980-08-25T00:00:001980Conservation and DNA sequence arrangement of the DNA polymerase I gene region from Klebsiella aerogenes, Klebsiella pneumoniae and Escherichia coli.7027262Struhl KProceedings of the National Academy of Sciences of the United States of AmericaDeletion mapping a eukaryotic promoter. Proc Natl Acad Sci U S A. 1981 Jul; 78(7):4461-5.Proc Natl Acad Sci U S A1981-07-01T00:00:001981Deletion mapping a eukaryotic promoter.3280970Kanazawa S, Driscoll M, Struhl KMolecular and cellular biologyATR1, a Saccharomyces cerevisiae gene encoding a transmembrane protein required for aminotriazole resistance. Mol Cell Biol. 1988 Feb; 8(2):664-73.Mol Cell Biol1988-02-01T00:00:001988ATR1, a Saccharomyces cerevisiae gene encoding a transmembrane protein required for aminotriazole resistance.Authorship 10338488524273Iyer V, Struhl KMolecular and cellular biologyMechanism of differential utilization of the his3 TR and TC TATA elements. Mol Cell Biol. 1995 Dec; 15(12):7059-66.Mol Cell Biol1995-12-01T00:00:001995Mechanism of differential utilization of the his3 TR and TC TATA elements.20129055Miotto B, Struhl KMolecular cellHBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin. Mol Cell. 2010 Jan 15; 37(1):57-66.Mol Cell2010-01-15T00:00:002010HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin.15149597Geisberg JV, Struhl KMolecular cellCellular stress alters the transcriptional properties of promoter-bound Mot1-TBP complexes. Mol Cell. 2004 May 21; 14(4):479-89.Mol Cell2004-05-21T00:00:002004Cellular stress alters the transcriptional properties of promoter-bound Mot1-TBP complexes.16087739Proft M, Gibbons FD, Copeland M, Roth FP, Struhl KEukaryotic cellGenomewide identification of Sko1 target promoters reveals a regulatory network that operates in response to osmotic stress in Saccharomyces cerevisiae. Eukaryot Cell. 2005 Aug; 4(8):1343-52.Eukaryot Cell2005-08-01T00:00:002005Genomewide identification of Sko1 target promoters reveals a regulatory network that operates in response to osmotic stress in Saccharomyces cerevisiae.18832067Miotto B, Struhl KGenes & developmentHBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1. Genes Dev. 2008 Oct 01; 22(19):2633-8.Genes Dev2008-10-01T00:00:002008HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1.2653813Chen W, Struhl KThe EMBO journalYeast upstream activator protein GCN4 can stimulate transcription when its binding site replaces the TATA element. EMBO J. 1989 Jan; 8(1):261-8.EMBO J1989-01-01T00:00:001989Yeast upstream activator protein GCN4 can stimulate transcription when its binding site replaces the TATA element.19878981Iliopoulos D, Hirsch HA, Struhl KCellAn epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell. 2009 Nov 13; 139(4):693-706.Cell2009-10-29T00:00:002009An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation.2567637Struhl G, Struhl K, Macdonald PMCellThe gradient morphogen bicoid is a concentration-dependent transcriptional activator. Cell. 1989 Jun 30; 57(7):1259-73.Cell1989-06-30T00:00:001989The gradient morphogen bicoid is a concentration-dependent transcriptional activator.3023181Oliphant AR, Nussbaum AL, Struhl KGeneCloning of random-sequence oligodeoxynucleotides. Gene. 1986; 44(2-3):177-83.Gene1986-01-01T00:00:001986Cloning of random-sequence oligodeoxynucleotides.3903516Struhl KNatureNegative control at a distance mediates catabolite repression in yeast. Nature. 1985 Oct 31-Nov 6; 317(6040):822-4.Nature1985-10-01T00:00:001985Negative control at a distance mediates catabolite repression in yeast.3909145Struhl KProceedings of the National Academy of Sciences of the United States of AmericaNaturally occurring poly(dA-dT) sequences are upstream promoter elements for constitutive transcription in yeast. Proc Natl Acad Sci U S A. 1985 Dec; 82(24):8419-23.Proc Natl Acad Sci U S A1985-12-01T00:00:001985Naturally occurring poly(dA-dT) sequences are upstream promoter elements for constitutive transcription in yeast.2145515Weiss MA, Ellenberger T, Wobbe CR, Lee JP, Harrison SC, Struhl KNatureFolding transition in the DNA-binding domain of GCN4 on specific binding to DNA. Nature. 1990 Oct 11; 347(6293):575-8.Nature1990-10-11T00:00:001990Folding transition in the DNA-binding domain of GCN4 on specific binding to DNA.6323262Struhl KGeneDirect selection for gene replacement events in yeast. Gene. 1983 Dec; 26(2-3):231-41.Gene1983-12-01T00:00:001983Direct selection for gene replacement events in yeast.7604282Stargell LA, Struhl KScience (New York, N.Y.)The TBP-TFIIA interaction in the response to acidic activators in vivo. Science. 1995 Jul 07; 269(5220):75-8.Science1995-07-07T00:00:001995The TBP-TFIIA interaction in the response to acidic activators in vivo.7926734Cormack BP, Strubin M, Stargell LA, Struhl KGenes & developmentConserved and nonconserved functions of the yeast and human TATA-binding proteins. Genes Dev. 1994 Jun 01; 8(11):1335-43.Genes Dev1994-06-01T00:00:001994Conserved and nonconserved functions of the yeast and human TATA-binding proteins.8428577Collart MA, Struhl KThe EMBO journalCDC39, an essential nuclear protein that negatively regulates transcription and differentially affects the constitutive and inducible HIS3 promoters. EMBO J. 1993 Jan; 12(1):177-86.EMBO J1993-01-01T00:00:001993CDC39, an essential nuclear protein that negatively regulates transcription and differentially affects the constitutive and inducible HIS3 promoters.18429079Seidman CE, Struhl KCurrent protocols in protein scienceIntroduction of plasmid DNA into cells. Curr Protoc Protein Sci. 2001 May; Appendix 4:4D.Curr Protoc Protein Sci2001-05-01T00:00:002001Introduction of plasmid DNA into cells.Authorship 1066936729802342Ji Z, He L, Rotem A, Janzer A, Cheng CS, Regev A, Struhl KNature communicationsGenome-scale identification of transcription factors that mediate an inflammatory network during breast cellular transformation. Nat Commun. 2018 05 25; 9(1):2068.Nat Commun2018-05-25T00:00:002018Genome-scale identification of transcription factors that mediate an inflammatory network during breast cellular transformation.21220315Iliopoulos D, Hirsch HA, Wang G, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaInducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1397-402.Proc Natl Acad Sci U S A2011-01-10T00:00:002011Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion.12192044Deckert J, Struhl KMolecular and cellular biologyTargeted recruitment of Rpd3 histone deacetylase represses transcription by inhibiting recruitment of Swi/Snf, SAGA, and TATA binding protein. Mol Cell Biol. 2002 Sep; 22(18):6458-70.Mol Cell Biol2002-09-01T00:00:002002Targeted recruitment of Rpd3 histone deacetylase represses transcription by inhibiting recruitment of Swi/Snf, SAGA, and TATA binding protein.12297514Hall DB, Struhl KThe Journal of biological chemistryThe VP16 activation domain interacts with multiple transcriptional components as determined by protein-protein cross-linking in vivo. J Biol Chem. 2002 Nov 29; 277(48):46043-50.J Biol Chem2002-09-23T00:00:002002The VP16 activation domain interacts with multiple transcriptional components as determined by protein-protein cross-linking in vivo.388229Stinchcomb DT, Struhl K, Davis RWNatureIsolation and characterisation of a yeast chromosomal replicator. Nature. 1979 Nov 01; 282(5734):39-43.Nature1979-11-01T00:00:001979Isolation and characterisation of a yeast chromosomal replicator.1873025Struhl KNeuronMechanisms for diversity in gene expression patterns. Neuron. 1991 Aug; 7(2):177-81.Neuron1991-08-01T00:00:001991Mechanisms for diversity in gene expression patterns.15780930Struhl KMolecular cellTranscriptional activation: mediator can act after preinitiation complex formation. Mol Cell. 2005 Mar 18; 17(6):752-4.Mol Cell2005-03-18T00:00:002005Transcriptional activation: mediator can act after preinitiation complex formation.17620451Peckham HE, Thurman RE, Fu Y, Stamatoyannopoulos JA, Noble WS, Struhl K, Weng ZGenome researchNucleosome positioning signals in genomic DNA. Genome Res. 2007 Aug; 17(8):1170-7.Genome Res2007-07-09T00:00:002007Nucleosome positioning signals in genomic DNA.Authorship 117695110581267Chou S, Chatterjee S, Lee M, Struhl KGeneticsTranscriptional activation in yeast cells lacking transcription factor IIA. Genetics. 1999 Dec; 153(4):1573-81.Genetics1999-12-01T00:00:001999Transcriptional activation in yeast cells lacking transcription factor IIA.2649888Brandl CJ, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaYeast GCN4 transcriptional activator protein interacts with RNA polymerase II in vitro. Proc Natl Acad Sci U S A. 1989 Apr; 86(8):2652-6.Proc Natl Acad Sci U S A1989-04-01T00:00:001989Yeast GCN4 transcriptional activator protein interacts with RNA polymerase II in vitro.22720264Yuan CC, Matthews AG, Jin Y, Chen CF, Chapman BA, Ohsumi TK, Glass KC, Kutateladze TG, Borowsky ML, Struhl K, Oettinger MACell reportsHistone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes. Cell Rep. 2012 Feb 23; 1(2):83-90.Cell Rep2012-02-23T00:00:002012Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes.3040261Struhl KCellThe DNA-binding domains of the jun oncoprotein and the yeast GCN4 transcriptional activator protein are functionally homologous. Cell. 1987 Sep 11; 50(6):841-6.Cell1987-09-11T00:00:001987The DNA-binding domains of the jun oncoprotein and the yeast GCN4 transcriptional activator protein are functionally homologous.3282236Chen W, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaSaturation mutagenesis of a yeast his3 "TATA element": genetic evidence for a specific TATA-binding protein. Proc Natl Acad Sci U S A. 1988 Apr; 85(8):2691-5.Proc Natl Acad Sci U S A1988-04-01T00:00:001988Saturation mutagenesis of a yeast his3 "TATA element": genetic evidence for a specific TATA-binding protein.6353245Struhl KNatureThe new yeast genetics. Nature. 1983 Sep 29-Oct 5; 305(5933):391-7.Nature1983-09-01T00:00:001983The new yeast genetics.7823962Ponticelli AS, Pardee TS, Struhl KMolecular and cellular biologyThe glutamine-rich activation domains of human Sp1 do not stimulate transcription in Saccharomyces cerevisiae. Mol Cell Biol. 1995 Feb; 15(2):983-8.Mol Cell Biol1995-02-01T00:00:001995The glutamine-rich activation domains of human Sp1 do not stimulate transcription in Saccharomyces cerevisiae.8211143Cormack BP, Struhl KScience (New York, N.Y.)Regional codon randomization: defining a TATA-binding protein surface required for RNA polymerase III transcription. Science. 1993 Oct 08; 262(5131):244-8.Science1993-10-08T00:00:001993Regional codon randomization: defining a TATA-binding protein surface required for RNA polymerase III transcription.8414991Pu WT, Struhl KNucleic acids researchDimerization of leucine zippers analyzed by random selection. Nucleic Acids Res. 1993 Sep 11; 21(18):4348-55.Nucleic Acids Res1993-09-11T00:00:001993Dimerization of leucine zippers analyzed by random selection.3481016Hill DE, Oliphant AR, Struhl KMethods in enzymologyMutagenesis with degenerate oligonucleotides: an efficient method for saturating a defined DNA region with base pair substitutions. Methods Enzymol. 1987; 155:558-68.Methods Enzymol1987-01-01T00:00:001987Mutagenesis with degenerate oligonucleotides: an efficient method for saturating a defined DNA region with base pair substitutions.20832727Iliopoulos D, Lindahl-Allen M, Polytarchou C, Hirsch HA, Tsichlis PN, Struhl KMolecular cellLoss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol Cell. 2010 Sep 10; 39(5):761-72.Mol Cell2010-09-10T00:00:002010Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells.21670079Iliopoulos D, Rotem A, Struhl KCancer researchInhibition of miR-193a expression by Max and RXRa activates K-Ras and PLAU to mediate distinct aspects of cellular transformation. Cancer Res. 2011 Aug 01; 71(15):5144-53.Cancer Res2011-06-13T00:00:002011Inhibition of miR-193a expression by Max and RXRa activates K-Ras and PLAU to mediate distinct aspects of cellular transformation.18265092Struhl KCurrent protocols in molecular biologyAnalysis of DNA-protein interactions using proteins synthesized in vitro from cloned genes. Curr Protoc Mol Biol. 2001 May; Chapter 12:Unit 12.9.Curr Protoc Mol Biol2001-05-01T00:00:002001Analysis of DNA-protein interactions using proteins synthesized in vitro from cloned genes.18428222Tabor S, Struhl KCurrent protocols in human geneticsEnzymatic labeling of DNA. Curr Protoc Hum Genet. 2001 May; Appendix 3:Appendix 3E.Curr Protoc Hum Genet2001-05-01T00:00:002001Enzymatic labeling of DNA.19825827Iliopoulos D, Polytarchou C, Hatziapostolou M, Kottakis F, Maroulakou IG, Struhl K, Tsichlis PNScience signalingMicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells. Sci Signal. 2009 Oct 13; 2(92):ra62.Sci Signal2009-10-13T00:00:002009MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells.17157257Reppas NB, Wade JT, Church GM, Struhl KMolecular cellThe transition between transcriptional initiation and elongation in E. coli is highly variable and often rate limiting. Mol Cell. 2006 Dec 08; 24(5):747-757.Mol Cell2006-12-08T00:00:002006The transition between transcriptional initiation and elongation in E. coli is highly variable and often rate limiting.Authorship 1106323678204Hope IA, Struhl KThe EMBO journalGCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA. EMBO J. 1987 Sep; 6(9):2781-4.EMBO J1987-09-01T00:00:001987GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA.7939664Klein C, Struhl KScience (New York, N.Y.)Increased recruitment of TATA-binding protein to the promoter by transcriptional activation domains in vivo. Science. 1994 Oct 14; 266(5183):280-2.Science1994-10-14T00:00:001994Increased recruitment of TATA-binding protein to the promoter by transcriptional activation domains in vivo.8643554Iyer V, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaAbsolute mRNA levels and transcriptional initiation rates in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5208-12.Proc Natl Acad Sci U S A1996-05-28T00:00:001996Absolute mRNA levels and transcriptional initiation rates in Saccharomyces cerevisiae.1262316Struhl K, Magasanik BJournal of bacteriologyAmmonia-sensitive mutant of Klebsiella aerogenes. J Bacteriol. 1976 May; 126(2):739-42.J Bacteriol1976-05-01T00:00:001976Ammonia-sensitive mutant of Klebsiella aerogenes.Authorship 1086799230089253Gameiro PA, Struhl KCell reportsNutrient Deprivation Elicits a Transcriptional and Translational Inflammatory Response Coupled to Decreased Protein Synthesis. Cell Rep. 2018 08 07; 24(6):1415-1424.Cell Rep2018-08-07T00:00:002018Nutrient Deprivation Elicits a Transcriptional and Translational Inflammatory Response Coupled to Decreased Protein Synthesis.3287180Hope IA, Mahadevan S, Struhl KNatureStructural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein. Nature. 1988 Jun 16; 333(6174):635-40.Nature1988-06-16T00:00:001988Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein.18228445Aparicio O, Geisberg JV, Struhl KCurrent protocols in cell biologyChromatin immunoprecipitation for determining the association of proteins with specific genomic sequences in vivo. Curr Protoc Cell Biol. 2004 Sep; Chapter 17:Unit 17.7.Curr Protoc Cell Biol2004-09-01T00:00:002004Chromatin immunoprecipitation for determining the association of proteins with specific genomic sequences in vivo.19620965Zhang Y, Moqtaderi Z, Rattner BP, Euskirchen G, Snyder M, Kadonaga JT, Liu XS, Struhl KNature structural & molecular biologyIntrinsic histone-DNA interactions are not the major determinant of nucleosome positions in vivo. Nat Struct Mol Biol. 2009 Aug; 16(8):847-52.Nat Struct Mol Biol2009-07-20T00:00:002009Intrinsic histone-DNA interactions are not the major determinant of nucleosome positions in vivo.8114723Klein C, Struhl KMolecular and cellular biologyProtein kinase A mediates growth-regulated expression of yeast ribosomal protein genes by modulating RAP1 transcriptional activity. Mol Cell Biol. 1994 Mar; 14(3):1920-8.Mol Cell Biol1994-03-01T00:00:001994Protein kinase A mediates growth-regulated expression of yeast ribosomal protein genes by modulating RAP1 transcriptional activity.19343176Fan X, Struhl KPloS oneWhere does mediator bind in vivo? PLoS One. 2009; 4(4):e5029.PLoS One2009-04-03T00:00:002009Where does mediator bind in vivo?22055187Krebs AR, Karmodiya K, Lindahl-Allen M, Struhl K, Tora LMolecular cellSAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers. Mol Cell. 2011 Nov 04; 44(3):410-423.Mol Cell2011-11-04T00:00:002011SAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers.3530496Hope IA, Struhl KCellFunctional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Cell. 1986 Sep 12; 46(6):885-94.Cell1986-09-12T00:00:001986Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast.3532321Hill DE, Hope IA, Macke JP, Struhl KScience (New York, N.Y.)Saturation mutagenesis of the yeast his3 regulatory site: requirements for transcriptional induction and for binding by GCN4 activator protein. Science. 1986 Oct 24; 234(4775):451-7.Science1986-10-24T00:00:001986Saturation mutagenesis of the yeast his3 regulatory site: requirements for transcriptional induction and for binding by GCN4 activator protein.Authorship 127422221930916Tirosh I, Wong KH, Barkai N, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaExtensive divergence of yeast stress responses through transitions between induced and constitutive activation. Proc Natl Acad Sci U S A. 2011 Oct 04; 108(40):16693-8.Proc Natl Acad Sci U S A2011-09-19T00:00:002011Extensive divergence of yeast stress responses through transitions between induced and constitutive activation.Authorship 104362218338317Moqtaderi Z, Struhl KYeast (Chichester, England)Expanding the repertoire of plasmids for PCR-mediated epitope tagging in yeast. Yeast. 2008 Apr; 25(4):287-92.Yeast2008-04-01T00:00:002008Expanding the repertoire of plasmids for PCR-mediated epitope tagging in yeast.Authorship 1093420730224479Li BB, Qian C, Gameiro PA, Liu CC, Jiang T, Roberts TM, Struhl K, Zhao JJProceedings of the National Academy of Sciences of the United States of AmericaTargeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):E9325-E9332.Proc Natl Acad Sci U S A2018-09-17T00:00:002018Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins.375221Struhl K, Stinchcomb DT, Scherer S, Davis RWProceedings of the National Academy of Sciences of the United States of AmericaHigh-frequency transformation of yeast: autonomous replication of hybrid DNA molecules. Proc Natl Acad Sci U S A. 1979 Mar; 76(3):1035-9.Proc Natl Acad Sci U S A1979-03-01T00:00:001979High-frequency transformation of yeast: autonomous replication of hybrid DNA molecules.23463311Struhl K, Segal ENature structural & molecular biologyDeterminants of nucleosome positioning. Nat Struct Mol Biol. 2013 Mar; 20(3):267-73.Nat Struct Mol Biol2013-03-01T00:00:002013Determinants of nucleosome positioning.3304661Chen W, Tabor S, Struhl KCellDistinguishing between mechanisms of eukaryotic transcriptional activation with bacteriophage T7 RNA polymerase. Cell. 1987 Sep 25; 50(7):1047-55.Cell1987-09-25T00:00:001987Distinguishing between mechanisms of eukaryotic transcriptional activation with bacteriophage T7 RNA polymerase.3540601Struhl KMolecular and cellular biologyConstitutive and inducible Saccharomyces cerevisiae promoters: evidence for two distinct molecular mechanisms. Mol Cell Biol. 1986 Nov; 6(11):3847-53.Mol Cell Biol1986-11-01T00:00:001986Constitutive and inducible Saccharomyces cerevisiae promoters: evidence for two distinct molecular mechanisms.7630732Kim J, Struhl KNucleic acids researchDeterminants of half-site spacing preferences that distinguish AP-1 and ATF/CREB bZIP domains. Nucleic Acids Res. 1995 Jul 11; 23(13):2531-7.Nucleic Acids Res1995-07-11T00:00:001995Determinants of half-site spacing preferences that distinguish AP-1 and ATF/CREB bZIP domains.15542822Schwabish MA, Struhl KMolecular and cellular biologyEvidence for eviction and rapid deposition of histones upon transcriptional elongation by RNA polymerase II. Mol Cell Biol. 2004 Dec; 24(23):10111-7.Mol Cell Biol2004-12-01T00:00:002004Evidence for eviction and rapid deposition of histones upon transcriptional elongation by RNA polymerase II.15596728Wade JT, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaAssociation of RNA polymerase with transcribed regions in Escherichia coli. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17777-82.Proc Natl Acad Sci U S A2004-12-13T00:00:002004Association of RNA polymerase with transcribed regions in Escherichia coli.16429153Fan X, Chou DM, Struhl KNature structural & molecular biologyActivator-specific recruitment of Mediator in vivo. Nat Struct Mol Biol. 2006 Feb; 13(2):117-20.Nat Struct Mol Biol2006-01-22T00:00:002006Activator-specific recruitment of Mediator in vivo.8352970Struhl KCurrent opinion in cell biologyYeast transcription factors. Curr Opin Cell Biol. 1993 Jun; 5(3):513-20.Curr Opin Cell Biol1993-06-01T00:00:001993Yeast transcription factors.18228638Struhl KCurrent biology : CBKevin Struhl. Interview. Curr Biol. 2008 Jan 08; 18(1):R7-9.Curr Biol2008-01-08T00:00:002008Kevin Struhl. Interview.Authorship 110336713Authorship 1106267330337373Koutsioumpa M, Hatziapostolou M, Polytarchou C, Tolosa EJ, Almada LL, Mahurkar-Joshi S, Williams J, Tirado-Rodriguez AB, Huerta-Yepez S, Karavias D, Kourea H, Poultsides GA, Struhl K, Dawson DW, Donahue TR, Fernández-Zapico ME, Iliopoulos DGutLysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming. Gut. 2019 07; 68(7):1271-1286.Gut2018-10-18T00:00:002018Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming.30318446Moqtaderi Z, Geisberg JV, Struhl KMolecular cellExtensive Structural Differences of Closely Related 3' mRNA Isoforms: Links to Pab1 Binding and mRNA Stability. Mol Cell. 2018 12 06; 72(5):849-861.e6.Mol Cell2018-10-11T00:00:002018Extensive Structural Differences of Closely Related 3' mRNA Isoforms: Links to Pab1 Binding and mRNA Stability.9512514Kadosh D, Struhl KGenes & developmentHistone deacetylase activity of Rpd3 is important for transcriptional repression in vivo. Genes Dev. 1998 Mar 15; 12(6):797-805.Genes Dev1998-03-15T00:00:001998Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo.7926748Collart MA, Struhl KGenes & developmentNOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization. Genes Dev. 1994 Mar 01; 8(5):525-37.Genes Dev1994-03-01T00:00:001994NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization.8196615Arndt KM, Wobbe CR, Ricupero-Hovasse S, Struhl K, Winston FMolecular and cellular biologyEquivalent mutations in the two repeats of yeast TATA-binding protein confer distinct TATA recognition specificities. Mol Cell Biol. 1994 Jun; 14(6):3719-28.Mol Cell Biol1994-06-01T00:00:001994Equivalent mutations in the two repeats of yeast TATA-binding protein confer distinct TATA recognition specificities.8506292Kim J, Tzamarias D, Ellenberger T, Harrison SC, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaAdaptability at the protein-DNA interface is an important aspect of sequence recognition by bZIP proteins. Proc Natl Acad Sci U S A. 1993 May 15; 90(10):4513-7.Proc Natl Acad Sci U S A1993-05-15T00:00:001993Adaptability at the protein-DNA interface is an important aspect of sequence recognition by bZIP proteins.Authorship 127359120921369Fan X, Moqtaderi Z, Jin Y, Zhang Y, Liu XS, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaNucleosome depletion at yeast terminators is not intrinsic and can occur by a transcriptional mechanism linked to 3'-end formation. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):17945-50.Proc Natl Acad Sci U S A2010-10-04T00:00:002010Nucleosome depletion at yeast terminators is not intrinsic and can occur by a transcriptional mechanism linked to 3'-end formation.8181058Engelberg D, Klein C, Martinetto H, Struhl K, Karin MCellThe UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals. Cell. 1994 May 06; 77(3):381-90.Cell1994-05-06T00:00:001994The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals.1473154Ellenberger TE, Brandl CJ, Struhl K, Harrison SCCellThe GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex. Cell. 1992 Dec 24; 71(7):1223-37.Cell1992-12-24T00:00:001992The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex.14585989Mason PB, Struhl KMolecular and cellular biologyThe FACT complex travels with elongating RNA polymerase II and is important for the fidelity of transcriptional initiation in vivo. Mol Cell Biol. 2003 Nov; 23(22):8323-33.Mol Cell Biol2003-11-01T00:00:002003The FACT complex travels with elongating RNA polymerase II and is important for the fidelity of transcriptional initiation in vivo.16277751Gibbons FD, Proft M, Struhl K, Roth FPGenome biologyChipper: discovering transcription-factor targets from chromatin immunoprecipitation microarrays using variance stabilization. Genome Biol. 2005; 6(11):R96.Genome Biol2005-11-01T00:00:002005Chipper: discovering transcription-factor targets from chromatin immunoprecipitation microarrays using variance stabilization.16857590Proft M, Mas G, de Nadal E, Vendrell A, Noriega N, Struhl K, Posas FMolecular cellThe stress-activated Hog1 kinase is a selective transcriptional elongation factor for genes responding to osmotic stress. Mol Cell. 2006 Jul 21; 23(2):241-50.Mol Cell2006-07-21T00:00:002006The stress-activated Hog1 kinase is a selective transcriptional elongation factor for genes responding to osmotic stress.3543377Struhl KJournal of molecular biologyYeast HIS3 expression in Escherichia coli depends upon fortuitous homology between eukaryotic and prokaryotic promoter elements. J Mol Biol. 1986 Sep 20; 191(2):221-9.J Mol Biol1986-09-20T00:00:001986Yeast HIS3 expression in Escherichia coli depends upon fortuitous homology between eukaryotic and prokaryotic promoter elements.6990004Brennan MB, Struhl KJournal of molecular biologyMechanisms of increasing expression of a yeast gene in Escherichia coli. J Mol Biol. 1980 Jan 25; 136(3):333-8.J Mol Biol1980-01-25T00:00:001980Mechanisms of increasing expression of a yeast gene in Escherichia coli.Authorship 1442583Authorship 111356417571346Birney E, Stamatoyannopoulos JA, Dutta A, Guigó R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, Thurman RE, Kuehn MS, Taylor CM, Neph S, Koch CM, Asthana S, Malhotra A, Adzhubei I, Greenbaum JA, Andrews RM, Flicek P, Boyle PJ, Cao H, Carter NP, Clelland GK, Davis S, Day N, Dhami P, Dillon SC, Dorschner MO, Fiegler H, Giresi PG, Goldy J, Hawrylycz M, Haydock A, Humbert R, James KD, Johnson BE, Johnson EM, Frum TT, Rosenzweig ER, Karnani N, Lee K, Lefebvre GC, Navas PA, Neri F, Parker SC, Sabo PJ, Sandstrom R, Shafer A, Vetrie D, Weaver M, Wilcox S, Yu M, Collins FS, Dekker J, Lieb JD, Tullius TD, Crawford GE, Sunyaev S, Noble WS, Dunham I, Denoeud F, Reymond A, Kapranov P, Rozowsky J, Zheng D, Castelo R, Frankish A, Harrow J, Ghosh S, Sandelin A, Hofacker IL, Baertsch R, Keefe D, Dike S, Cheng J, Hirsch HA, Sekinger EA, Lagarde J, Abril JF, Shahab A, Flamm C, Fried C, Hackermüller J, Hertel J, Lindemeyer M, Missal K, Tanzer A, Washietl S, Korbel J, Emanuelsson O, Pedersen JS, Holroyd N, Taylor R, Swarbreck D, Matthews N, Dickson MC, Thomas DJ, Weirauch MT, Gilbert J, Drenkow J, Bell I, Zhao X, Srinivasan KG, Sung WK, Ooi HS, Chiu KP, Foissac S, Alioto T, Brent M, Pachter L, Tress ML, Valencia A, Choo SW, Choo CY, Ucla C, Manzano C, Wyss C, Cheung E, Clark TG, Brown JB, Ganesh M, Patel S, Tammana H, Chrast J, Henrichsen CN, Kai C, Kawai J, Nagalakshmi U, Wu J, Lian Z, Lian J, Newburger P, Zhang X, Bickel P, Mattick JS, Carninci P, Hayashizaki Y, Weissman S, Hubbard T, Myers RM, Rogers J, Stadler PF, Lowe TM, Wei CL, Ruan Y, Struhl K, Gerstein M, Antonarakis SE, Fu Y, Green ED, Karaöz U, Siepel A, Taylor J, Liefer LA, Wetterstrand KA, Good PJ, Feingold EA, Guyer MS, Cooper GM, Asimenos G, Dewey CN, Hou M, Nikolaev S, Montoya-Burgos JI, Löytynoja A, Whelan S, Pardi F, Massingham T, Huang H, Zhang NR, Holmes I, Mullikin JC, Ureta-Vidal A, Paten B, Seringhaus M, Church D, Rosenbloom K, Kent WJ, Stone EA, Batzoglou S, Goldman N, Hardison RC, Haussler D, Miller W, Sidow A, Trinklein ND, Zhang ZD, Barrera L, Stuart R, King DC, Ameur A, Enroth S, Bieda MC, Kim J, Bhinge AA, Jiang N, Liu J, Yao F, Vega VB, Lee CW, Ng P, Shahab A, Yang A, Moqtaderi Z, Zhu Z, Xu X, Squazzo S, Oberley MJ, Inman D, Singer MA, Richmond TA, Munn KJ, Rada-Iglesias A, Wallerman O, Komorowski J, Fowler JC, Couttet P, Bruce AW, Dovey OM, Ellis PD, Langford CF, Nix DA, Euskirchen G, Hartman S, Urban AE, Kraus P, Van Calcar S, Heintzman N, Kim TH, Wang K, Qu C, Hon G, Luna R, Glass CK, Rosenfeld MG, Aldred SF, Cooper SJ, Halees A, Lin JM, Shulha HP, Zhang X, Xu M, Haidar JN, Yu Y, Ruan Y, Iyer VR, Green RD, Wadelius C, Farnham PJ, Ren B, Harte RA, Hinrichs AS, Trumbower H, Clawson H, Hillman-Jackson J, Zweig AS, Smith K, Thakkapallayil A, Barber G, Kuhn RM, Karolchik D, Armengol L, Bird CP, de Bakker PI, Kern AD, Lopez-Bigas N, Martin JD, Stranger BE, Woodroffe A, Davydov E, Dimas A, Eyras E, Hallgrímsdóttir IB, Huppert J, Zody MC, Abecasis GR, Estivill X, Bouffard GG, Guan X, Hansen NF, Idol JR, Maduro VV, Maskeri B, McDowell JC, Park M, Thomas PJ, Young AC, Blakesley RW, Muzny DM, Sodergren E, Wheeler DA, Worley KC, Jiang H, Weinstock GM, Gibbs RA, Graves T, Fulton R, Mardis ER, Wilson RK, Clamp M, Cuff J, Gnerre S, Jaffe DB, Chang JL, Lindblad-Toh K, Lander ES, Koriabine M, Nefedov M, Osoegawa K, Yoshinaga Y, Zhu B, de Jong PJNatureIdentification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007 Jun 14; 447(7146):799-816.Nature2007-06-14T00:00:002007Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.18265358Aparicio O, Geisberg JV, Sekinger E, Yang A, Moqtaderi Z, Struhl KCurrent protocols in molecular biologyChromatin immunoprecipitation for determining the association of proteins with specific genomic sequences in vivo. Curr Protoc Mol Biol. 2005 Feb; Chapter 21:Unit 21.3.Curr Protoc Mol Biol2005-02-01T00:00:002005Chromatin immunoprecipitation for determining the association of proteins with specific genomic sequences in vivo.18927256Struhl KGeneticsThe hisB463 mutation and expression of a eukaryotic protein in Escherichia coli. Genetics. 2008 Oct; 180(2):709-14.Genetics2008-10-01T00:00:002008The hisB463 mutation and expression of a eukaryotic protein in Escherichia coli.377096Struhl K, Davis RW, Fink GRNatureSuppression of a yeast amber mutation in Escherichia coli. Nature. 1979 May 03; 279(5708):78-9.Nature1979-05-03T00:00:001979Suppression of a yeast amber mutation in Escherichia coli.6096864Struhl KProceedings of the National Academy of Sciences of the United States of AmericaGenetic properties and chromatin structure of the yeast gal regulatory element: an enhancer-like sequence. Proc Natl Acad Sci U S A. 1984 Dec; 81(24):7865-9.Proc Natl Acad Sci U S A1984-12-01T00:00:001984Genetic properties and chromatin structure of the yeast gal regulatory element: an enhancer-like sequence.10958664Mai X, Chou S, Struhl KMolecular and cellular biologyPreferential accessibility of the yeast his3 promoter is determined by a general property of the DNA sequence, not by specific elements. Mol Cell Biol. 2000 Sep; 20(18):6668-76.Mol Cell Biol2000-09-01T00:00:002000Preferential accessibility of the yeast his3 promoter is determined by a general property of the DNA sequence, not by specific elements.1549559Tzamarias D, Pu WT, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaMutations in the bZIP domain of yeast GCN4 that alter DNA-binding specificity. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2007-11.Proc Natl Acad Sci U S A1992-03-15T00:00:001992Mutations in the bZIP domain of yeast GCN4 that alter DNA-binding specificity.Authorship 11057214701747Reid JL, Moqtaderi Z, Struhl KMolecular and cellular biologyEaf3 regulates the global pattern of histone acetylation in Saccharomyces cerevisiae. Mol Cell Biol. 2004 Jan; 24(2):757-64.Mol Cell Biol2004-01-01T00:00:002004Eaf3 regulates the global pattern of histone acetylation in Saccharomyces cerevisiae.17188034Yang A, Zhu Z, Kapranov P, McKeon F, Church GM, Gingeras TR, Struhl KMolecular cellRelationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells. Mol Cell. 2006 Nov 17; 24(4):593-602.Mol Cell2006-11-17T00:00:002006Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells.2204805Sellers JW, Vincent AC, Struhl KMolecular and cellular biologyMutations that define the optimal half-site for binding yeast GCN4 activator protein and identify an ATF/CREB-like repressor that recognizes similar DNA sites. Mol Cell Biol. 1990 Oct; 10(10):5077-86.Mol Cell Biol1990-10-01T00:00:001990Mutations that define the optimal half-site for binding yeast GCN4 activator protein and identify an ATF/CREB-like repressor that recognizes similar DNA sites.18265240Greene JM, Struhl KCurrent protocols in molecular biologyS1 analysis of messenger RNA using single-stranded DNA probes. Curr Protoc Mol Biol. 2001 May; Chapter 4:Unit4.6.Curr Protoc Mol Biol2001-05-01T00:00:002001S1 analysis of messenger RNA using single-stranded DNA probes.18765474Fan X, Lamarre-Vincent N, Wang Q, Struhl KNucleic acids researchExtensive chromatin fragmentation improves enrichment of protein binding sites in chromatin immunoprecipitation experiments. Nucleic Acids Res. 2008 Nov; 36(19):e125.Nucleic Acids Res2008-09-02T00:00:002008Extensive chromatin fragmentation improves enrichment of protein binding sites in chromatin immunoprecipitation experiments.Authorship 1127694530681409Petrenko N, Jin Y, Dong L, Wong KH, Struhl KeLifeRequirements for RNA polymerase II preinitiation complex formation in vivo. Elife. 2019 01 25; 8.Elife2019-01-25T00:00:002019Requirements for RNA polymerase II preinitiation complex formation in vivo.7035683Struhl K, Davis RWJournal of molecular biologyPosition effects in Saccharomyces cerevisiae. J Mol Biol. 1981 Nov 05; 152(3):569-75.J Mol Biol1981-11-05T00:00:001981Position effects in Saccharomyces cerevisiae.Authorship 1188012D014158Physiology221177090.355369Transcription, GeneticD029701Chemicals & Drugs52618840.48734Saccharomyces cerevisiae ProteinsD012319Chemicals & Drugs2385510.712235RNA Polymerase IID012441Living Beings76427480.442027Saccharomyces cerevisiaeAuthorship 1136022Authorship 1143210430910960Ji Z, He L, Regev A, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaInflammatory regulatory network mediated by the joint action of NF-kB, STAT3, and AP-1 factors is involved in many human cancers. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9453-9462.Proc Natl Acad Sci U S A2019-03-25T00:00:002019Inflammatory regulatory network mediated by the joint action of NF-kB, STAT3, and AP-1 factors is involved in many human cancers.D011401Chemicals & Drugs194458630.425115Promoter Regions, GeneticAuthorship 124482Cell BiologyGeneticsMedicinePediatricsSystems BiologyCardiologyOncologyBrigham and Women's HospitalBoston Children's HospitalDana-Farber Cancer InstituteHarvard Medical SchoolABL6AndrewLassarAndrew B. Lassar, Ph.D.42.33588600000000-71.1051460000000019841Lassar, AndrewProfessor of Biological Chemistry and Molecular PharmacologyZL23ZongliLiZongli Li, Ph.D.42.33588600000000-71.1051460000000084770Li, ZongliLecturer on Biological Chemistry and Molecular PharmacologyAR186AsafRotemAsaf Rotem, Ph.D.42.33588600000000-71.1051460000000070007Rotem, AsafResearch Associate in MedicineSB3StephenBuratowskiStephen Buratowski, Ph.D.42.33588600000000-71.1051460000000029782Buratowski, StephenHamilton Kuhn Professor of Biological Chemistry and Molecular PharmacologyWTP2WilliamPuWilliam T. Pu, M.D.42.33743600000000-71.105447000000001355Pu, WilliamAldo R. Castaneda Professor of Pediatrics in the Field of Cardiovascular ResearchJVG1JosephGeisbergJoseph V. Geisberg, Ph.D.42.33588600000000-71.1051460000000060935Geisberg, JosephResearch Associate in Biological Chemistry and Molecular Pharmacology11303selected publications10.58370.00410869670research areas7.066940.0067318435coauthor of360.79842.258760similar toSJE2StephenElledgeStephen J. Elledge, Ph.D.42.33837200000000-71.1032690000000032424Elledge, StephenGregor Mendel Professor of Genetics and of MedicineSPG4StevenGygiSteven P. Gygi, Ph.D.42.33588600000000-71.1051460000000028969Gygi, StevenProfessor of Cell BiologyPAS1PamelaSilverPamela A. Silver, Ph.D.42.33594500000000-71.1029580000000033128Silver, PamelaElliott T. and Onie H. Adams Professor of Biochemistry and Systems BiologyST12StanleyTaborStanley Tabor, Ph.D.42.33588600000000-71.1051460000000055162Tabor, StanleyLecturer on Biological Chemistry and Molecular PharmacologyFMW1FredWinstonFred Winston, Ph.D.42.33837200000000-71.1032690000000032931Winston, FredJohn Emory Andrus Professor of GeneticsZM2ZarmikMoqtaderiZarmik Moqtaderi, D.E.A., Ph.D.42.33588600000000-71.1051460000000073526Moqtaderi, ZarmikInstructor in Biological Chemistry and Molecular Pharmacology2024-06-30STRUHL, KEVIN2019-07-01Mechanism of yeast gene regulationR35GM131801Principal InvestigatorAuthorship 1355942Authorship 1204445231732535Hasegawa Y, Struhl KGenome researchPromoter-specific dynamics of TATA-binding protein association with the human genome. Genome Res. 2019 12; 29(12):1939-1950.Genome Res2019-11-15T00:00:002019Promoter-specific dynamics of TATA-binding protein association with the human genome.true1John Emory Andrus Professor of GeneticsJohn Emory Andrus Professor of Geneticstrue1Research Associate in MedicineResearch Associate in Medicinetrue1Elliott T. and Onie H. Adams Professor of Biochemistry and Systems BiologyElliott T. and Onie H. Adams Professor of Biochemistry and Systems BiologyAuthorship 1272227Authorship 1433311Authorship 1373192Authorship 130621Authorship 1333442Authorship 1240242Authorship 1786072Authorship 1617562Authorship 1317883Authorship 1986911Authorship 1534162Authorship 1573101true1Professor of Cell BiologyProfessor of Cell BiologyAuthorship 1279641332845240Geisberg JV, Moqtaderi Z, Struhl KeLifeThe transcriptional elongation rate regulates alternative polyadenylation in yeast. Elife. 2020 08 26; 9.Elife2020-08-26T00:00:002020The transcriptional elongation rate regulates alternative polyadenylation in yeast.true1Instructor in Biological Chemistry and Molecular PharmacologyInstructor in Biological Chemistry and Molecular Pharmacologytrue1Lecturer on Biological Chemistry and Molecular PharmacologyLecturer on Biological Chemistry and Molecular Pharmacologytrue1David Wesley Gaiser Professor of Biological Chemistry and Molecular PharmacologyDavid Wesley Gaiser Professor of Biological Chemistry and Molecular Pharmacologytrue1Lecturer on Biological Chemistry and Molecular PharmacologyLecturer on Biological Chemistry and Molecular PharmacologyBCMPAuthorship 1452373Authorship 1903794Authorship 1306166233144504Darwiche R, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaPheno-RNA, a method to associate genes with a specific phenotype, identifies genes linked to cellular transformation. Proc Natl Acad Sci U S A. 2020 11 17; 117(46):28925-28929.Proc Natl Acad Sci U S A2020-11-03T00:00:002020Pheno-RNA, a method to associate genes with a specific phenotype, identifies genes linked to cellular transformation.Authorship 2133297Authorship 1444943Authorship 1930251Authorship 1481692Authorship 2416281Authorship 1325911233523865Song R, Struhl KScience advancesS100A8/S100A9 cytokine acts as a transcriptional coactivator during breast cellular transformation. Sci Adv. 2021 01; 7(1).Sci Adv2021-01-01T00:00:002021S100A8/S100A9 cytokine acts as a transcriptional coactivator during breast cellular transformation.Authorship 1597802Authorship 1866402true1Professor of Biological Chemistry and Molecular PharmacologyProfessor of Biological Chemistry and Molecular PharmacologyAuthorship 1650702Authorship 1871511Authorship 1896856Authorship 1390943634463254He L, Pratt H, Gao M, Wei F, Weng Z, Struhl KeLifeYAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation. Elife. 2021 08 31; 10.Elife2021-08-31T00:00:002021YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation.Authorship 1733822Authorship 1394098234515029Petrenko N, Struhl KeLifeComparison of transcriptional initiation by RNA polymerase II across eukaryotic species. Elife. 2021 09 13; 10.Elife2021-09-13T00:00:002021Comparison of transcriptional initiation by RNA polymerase II across eukaryotic species.Authorship 1852511Authorship 1932312Authorship 2001023Authorship 1412647234764224Hasegawa Y, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaDifferent SP1 binding dynamics at individual genomic loci in human cells. Proc Natl Acad Sci U S A. 2021 11 16; 118(46).Proc Natl Acad Sci U S A2021-11-16T00:00:002021Different SP1 binding dynamics at individual genomic loci in human cells.35058367Moqtaderi Z, Geisberg JV, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaA compensatory link between cleavage/polyadenylation and mRNA turnover regulates steady-state mRNA levels in yeast. Proc Natl Acad Sci U S A. 2022 01 25; 119(4).Proc Natl Acad Sci U S A2022-01-25T00:00:002022A compensatory link between cleavage/polyadenylation and mRNA turnover regulates steady-state mRNA levels in yeast.Authorship 14271013Authorship 1448182535482762He L, Gao M, Pratt H, Weng Z, Struhl KPloS oneMafB, WDR77, and ß-catenin interact with each other and have similar genome association profiles. PLoS One. 2022; 17(4):e0264799.PLoS One2022-04-28T00:00:002022MafB, WDR77, and ß-catenin interact with each other and have similar genome association profiles.Authorship 374796Authorship 3870732Authorship 4107391Authorship 1493281435972270Lui KH, Geisberg JV, Moqtaderi Z, Struhl KMolecular and cellular biology3' Untranslated Regions Are Modular Entities That Determine Polyadenylation Profiles. Mol Cell Biol. 2022 09 15; 42(9):e0024422.Mol Cell Biol2022-08-16T00:00:0020223' Untranslated Regions Are Modular Entities That Determine Polyadenylation Profiles.Authorship 1505850636421680Geisberg JV, Moqtaderi Z, Fong N, Erickson B, Bentley DL, Struhl KeLifeNucleotide-level linkage of transcriptional elongation and polyadenylation. Elife. 2022 11 24; 11.Elife2022-11-24T00:00:002022Nucleotide-level linkage of transcriptional elongation and polyadenylation.Authorship 4626482Authorship 2137882Authorship 2201942Authorship 1728344Authorship 486772true1Research Associate in Biological Chemistry and Molecular PharmacologyResearch Associate in Biological Chemistry and Molecular Pharmacologytrue1Hamilton Kuhn Professor of Biological Chemistry and Molecular PharmacologyHamilton Kuhn Professor of Biological Chemistry and Molecular PharmacologyAuthorship 15515183Authorship 1555671337094136Geisberg JV, Moqtaderi Z, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaCondition-specific 3' mRNA isoform half-lives and stability elements in yeast. Proc Natl Acad Sci U S A. 2023 05 02; 120(18):e2301117120.Proc Natl Acad Sci U S A2023-04-24T00:00:002023Condition-specific 3' mRNA isoform half-lives and stability elements in yeast.37137302Gvozdenov Z, Barcutean Z, Struhl KMolecular cellFunctional analysis of a random-sequence chromosome reveals a high level and the molecular nature of transcriptional noise in yeast cells. Mol Cell. 2023 06 01; 83(11):1786-1797.e5.Mol Cell2023-05-02T00:00:002023Functional analysis of a random-sequence chromosome reveals a high level and the molecular nature of transcriptional noise in yeast cells.Authorship 2126892Authorship 2215032Authorship 1582861637748648Khitun A, Brion C, Moqtaderi Z, Geisberg JV, Churchman LS, Struhl KThe Journal of biological chemistryElongation rate of RNA polymerase II affects pausing patterns across 3' UTRs. J Biol Chem. 2023 11; 299(11):105289.J Biol Chem2023-09-24T00:00:002023Elongation rate of RNA polymerase II affects pausing patterns across 3' UTRs.Authorship 3815322Authorship 4079153true1Gregor Mendel Professor of Genetics and of MedicineGregor Mendel Professor of Genetics and of MedicineAuthorship 1608848138041485Struhl KYeast (Chichester, England)How is polyadenylation restricted to 3'-untranslated regions? Yeast. 2023 Dec 02.Yeast2023-12-02T00:00:002023How is polyadenylation restricted to 3'-untranslated regions?Authorship 5706532Authorship 1761526Authorship 1790283Authorship 5237452true1Aldo R. Castaneda Professor of Pediatrics in the Field of Cardiovascular ResearchAldo R. Castaneda Professor of Pediatrics in the Field of Cardiovascular ResearchAuthorship 5536911Authorship 5757951Authorship 60181Authorship 1560671Authorship 2545804Authorship 2812872Authorship 2891263Authorship 3064249Authorship 3165324Authorship 3468912Authorship 3518337Authorship 3830931Authorship 4070402Authorship 4857209Authorship 28331810Authorship 2974881Authorship 3082161Authorship 3334204Authorship 6467156Authorship 668410523776204Moqtaderi Z, Geisberg JV, Jin Y, Fan X, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaSpecies-specific factors mediate extensive heterogeneity of mRNA 3' ends in yeasts. Proc Natl Acad Sci U S A. 2013 Jul 02; 110(27):11073-8.Proc Natl Acad Sci U S A2013-06-17T00:00:002013Species-specific factors mediate extensive heterogeneity of mRNA 3' ends in yeasts.23595228Fleming JD, Pavesi G, Benatti P, Imbriano C, Mantovani R, Struhl KGenome researchNF-Y coassociates with FOS at promoters, enhancers, repetitive elements, and inactive chromatin regions, and is stereo-positioned with growth-controlling transcription factors. Genome Res. 2013 Aug; 23(8):1195-209.Genome Res2013-04-17T00:00:002013NF-Y coassociates with FOS at promoters, enhancers, repetitive elements, and inactive chromatin regions, and is stereo-positioned with growth-controlling transcription factors.Authorship 623712Authorship 640961Authorship 1996731Authorship 2008285Authorship 2104792Authorship 1842016Authorship 8412519Authorship 3043642Authorship 3217005Authorship 2117074Authorship 3709764Authorship 3743781Authorship 2227742Authorship 2344665Authorship 2406722Authorship 2506541Authorship 3926644Authorship 4501224Authorship 3181482Authorship 2614279Authorship 3862142Authorship 1982502Authorship 2919077Authorship 2056105Authorship 7241705Authorship 725230124623307Struhl KeLifeIs DNA methylation of tumour suppressor genes epigenetic? Elife. 2014 Mar 12; 3:e02475.Elife2014-03-12T00:00:002014Is DNA methylation of tumour suppressor genes epigenetic?24529382Geisberg JV, Moqtaderi Z, Fan X, Ozsolak F, Struhl KCellGlobal analysis of mRNA isoform half-lives reveals stabilizing and destabilizing elements in yeast. Cell. 2014 Feb 13; 156(4):812-24.Cell2014-02-13T00:00:002014Global analysis of mRNA isoform half-lives reveals stabilizing and destabilizing elements in yeast.Authorship 3027916Authorship 1845723Authorship 3718816Authorship 732184324746699Wong KH, Jin Y, Struhl KMolecular cellTFIIH phosphorylation of the Pol II CTD stimulates mediator dissociation from the preinitiation complex and promoter escape. Mol Cell. 2014 May 22; 54(4):601-12.Mol Cell2014-04-17T00:00:002014TFIIH phosphorylation of the Pol II CTD stimulates mediator dissociation from the preinitiation complex and promoter escape.Authorship 4259651Authorship 2737166Authorship 273766325002509Janzer A, German NJ, Gonzalez-Herrera KN, Asara JM, Haigis MC, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaMetformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10574-9.Proc Natl Acad Sci U S A2014-07-07T00:00:002014Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells.Authorship 7493716Authorship 5271941Authorship 5722651Authorship 3744943Authorship 3959471Authorship 4431991Authorship 2330192Authorship 4432483Authorship 5377312Authorship 2721076Authorship 2832004Authorship 3235301Authorship 5340382Authorship 5766074Authorship 3821911Authorship 4072292Authorship 4140981Authorship 4162225Authorship 3965972Authorship 3994693Authorship 4064382Authorship 4667722Authorship 4695201Authorship 4775276Authorship 4535162Authorship 458712Authorship 5103171Authorship 5142691Authorship 3840112Authorship 5356182Authorship 5275104Authorship 4956241Authorship 5471237Authorship 5465861Authorship 3122552Authorship 732571Authorship 4954431Authorship 5000223Authorship 5322982Authorship 5394042Authorship 5658462Authorship 5583682Authorship 5728092Authorship 32209145Authorship 2171721Authorship 876403Authorship 878052Authorship 254542Authorship 2635293Authorship 2810956Authorship 2870171Authorship 3365365Authorship 343801Authorship 3514003Authorship 2777252Authorship 3264513Authorship 3382202Authorship 2203651Authorship 3755972Authorship 3769051Authorship 3981201Authorship 4130043Authorship 441144Authorship 4543345Authorship 4875632Authorship 4886673Authorship 5008883Authorship 2240431Authorship 3386121Authorship 2579622Authorship 5269434Authorship 5724453Authorship 703062Authorship 251962Authorship 254711Authorship 3922404Authorship 4007564Authorship 4337183Authorship 4409512Authorship 2658416Authorship 456520148Authorship 2683934Authorship 3138983Authorship 3655193Authorship 3697532Authorship 4456112Authorship 4499023Authorship 5082472Authorship 1537132Authorship 2759201Authorship 4159502Authorship 4526973Authorship 5159133Authorship 8071337Authorship 7984506Authorship 799485725902495Rotem A, Janzer A, Izar B, Ji Z, Doench JG, Garraway LA, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaAlternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation. Proc Natl Acad Sci U S A. 2015 May 05; 112(18):5708-13.Proc Natl Acad Sci U S A2015-04-20T00:00:002015Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation.25827089Jin Y, Geisberg JV, Moqtaderi Z, Ji Z, Hoque M, Tian B, Struhl KCurrent protocols in molecular biologyMapping 3' mRNA isoforms on a genomic scale. Curr Protoc Mol Biol. 2015 Apr 01; 110:4.23.1-4.23.17.Curr Protoc Mol Biol2015-04-01T00:00:002015Mapping 3' mRNA isoforms on a genomic scale.25784959Fleming JD, Giresi PG, Lindahl-Allen M, Krall EB, Lieb JD, Struhl KEpigenetics & chromatinSTAT3 acts through pre-existing nucleosome-depleted regions bound by FOS during an epigenetic switch linking inflammation to cancer. Epigenetics Chromatin. 2015; 8:7.Epigenetics Chromatin2015-02-14T00:00:002015STAT3 acts through pre-existing nucleosome-depleted regions bound by FOS during an epigenetic switch linking inflammation to cancer.Authorship 3330341Authorship 3451972Authorship 2694067Authorship 3040093Authorship 3177654Authorship 3306503Authorship 334001Authorship 370684Authorship 4038961Authorship 53328611Authorship 5393563Authorship 4885635Authorship 4940141Authorship 5210932Authorship 3371642Authorship 3432292Authorship 3473462Authorship 357612Authorship 3849752Authorship 4100532Authorship 471022Authorship 4911121Authorship 5741042Authorship 622081Authorship 4685211Authorship 4865765Authorship 5347778Authorship 424632Authorship 4464981Authorship 4933942Authorship 858589426687005Ji Z, Song R, Regev A, Struhl KeLifeMany lncRNAs, 5'UTRs, and pseudogenes are translated and some are likely to express functional proteins. Elife. 2015 Dec 19; 4:e08890.Elife2015-12-19T00:00:002015Many lncRNAs, 5'UTRs, and pseudogenes are translated and some are likely to express functional proteins.Authorship 5722372Authorship 640163Authorship 866456820683474Zhang Y, Moqtaderi Z, Rattner BP, Euskirchen G, Snyder M, Kadonaga JT, Liu XS, Struhl KNature structural & molecular biologyEvidence against a genomic code for nucleosome positioning. Reply to "Nucleosome sequence preferences influence in vivo nucleosome organization.". Nat Struct Mol Biol. 2010 Aug; 17(8):920-3.Nat Struct Mol Biol2010-08-01T00:00:002010Evidence against a genomic code for nucleosome positioning. Reply to "Nucleosome sequence preferences influence in vivo nucleosome organization.".Authorship 731423Authorship 796062Authorship 311196226900662Ji Z, Song R, Huang H, Regev A, Struhl KNature biotechnologyTranscriptome-scale RNase-footprinting of RNA-protein complexes. Nat Biotechnol. 2016 Apr; 34(4):410-3.Nat Biotechnol2016-02-22T00:00:002016Transcriptome-scale RNase-footprinting of RNA-protein complexes.Authorship 8760215Authorship 3976702Authorship 4096022Authorship 477842Authorship 4899262Authorship 54928880Full Professor4Instructor3Lecturer5Other FacultyAuthorship 5532901Authorship 868464Authorship 535044Authorship 807016Authorship 900154327436900Miotto B, Ji Z, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaSelectivity of ORC binding sites and the relation to replication timing, fragile sites, and deletions in cancers. Proc Natl Acad Sci U S A. 2016 08 16; 113(33):E4810-9.Proc Natl Acad Sci U S A2016-07-19T00:00:002016Selectivity of ORC binding sites and the relation to replication timing, fragile sites, and deletions in cancers.Authorship 4790587Authorship 52739321995-07-31STRUHL, KEVIN1991-08-01DIMERIZATION &DNA BINDING SPECIFICITY OF BZIP PROTEINSR01GM0465552020-08-31STRUHL, KEVIN1982-03-01Mechanisms of yeast transcriptional initiationR01GM0301861999-06-30STRUHL, KEVIN1998-07-01TRANSCRIPTIONAL REG IN CELL GROWTH AND DEVELOPMENTR13CA0783172001-06-30STRUHL, KEVIN1995-09-07CELLULAR TRANSFORMATION BY AP-1 TRANSCRIPTION FACTORSR01CA0659652003-02-28STRUHL, KEVIN1982-03-01MECHANISMS OF YEAST TRANSCRIPTIONAL INITIATIONR37GM0301862009-12-31STRUHL, KEVIN1995-09-30Molecular Mechanisms of Global Represion in YeastR01GM0537202021-04-30STRUHL, KEVIN2004-05-25Genomic targets of oncoproteins and tumor suppressorsR01CA107486Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal Investigator27626181Henry WS, Hendrickson DG, Beca F, Glass B, Lindahl-Allen M, He L, Ji Z, Struhl K, Beck AH, Rinn JL, Toker AOncotargetLINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer. Oncotarget. 2016 Dec 13; 7(50):81981-81994.Oncotarget2016-12-13T00:00:002016LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer.Authorship 896172Authorship 3543911Authorship 3589282Authorship 9212803Authorship 928409425279376Moqtaderi Z, Geisberg JV, Struhl KMicrobial cell (Graz, Austria)Secondary structures involving the poly(A) tail and other 3' sequences are major determinants of mRNA isoform stability in yeast. Microb Cell. 2014 Apr; 1(4):137-139.Microb Cell2014-04-01T00:00:002014Secondary structures involving the poly(A) tail and other 3' sequences are major determinants of mRNA isoform stability in yeast.27773675Petrenko N, Jin Y, Wong KH, Struhl KMolecular cellMediator Undergoes a Compositional Change during Transcriptional Activation. Mol Cell. 2016 11 03; 64(3):443-454.Mol Cell2016-10-20T00:00:002016Mediator Undergoes a Compositional Change during Transcriptional Activation.Authorship 4442604Authorship 47997411Authorship 498152Authorship 1989334Authorship 2188492Authorship 2852081Authorship 2897582Authorship 2927745Authorship 3450933Authorship 36690342Authorship 9484778Authorship 5210302Authorship 5464394Authorship 5607481Authorship 5758714Authorship 609731Authorship 7429728825489Struhl KAnnual review of geneticsYeast transcriptional regulatory mechanisms. Annu Rev Genet. 1995; 29:651-74.Annu Rev Genet1995-01-01T00:00:001995Yeast transcriptional regulatory mechanisms.8754846Stargell LA, Struhl KMolecular and cellular biologyA new class of activation-defective TATA-binding protein mutants: evidence for two steps of transcriptional activation in vivo. Mol Cell Biol. 1996 Aug; 16(8):4456-64.Mol Cell Biol1996-08-01T00:00:001996A new class of activation-defective TATA-binding protein mutants: evidence for two steps of transcriptional activation in vivo.8774887Moqtaderi Z, Bai Y, Poon D, Weil PA, Struhl KNatureTBP-associated factors are not generally required for transcriptional activation in yeast. Nature. 1996 Sep 12; 383(6596):188-91.Nature1996-09-12T00:00:001996TBP-associated factors are not generally required for transcriptional activation in yeast.9011181Struhl KBiochimica et biophysica actaTranscriptional enhancement by acidic activators. Biochim Biophys Acta. 1996 Dec 09; 1288(3):O15-7.Biochim Biophys Acta1996-12-09T00:00:001996Transcriptional enhancement by acidic activators.9032260Lee M, Struhl KMolecular and cellular biologyA severely defective TATA-binding protein-TFIIB interaction does not preclude transcriptional activation in vivo. Mol Cell Biol. 1997 Mar; 17(3):1336-45.Mol Cell Biol1997-03-01T00:00:001997A severely defective TATA-binding protein-TFIIB interaction does not preclude transcriptional activation in vivo.8955276De Rubertis F, Kadosh D, Henchoz S, Pauli D, Reuter G, Struhl K, Spierer PNatureThe histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast. Nature. 1996 Dec 12; 384(6609):589-91.Nature1996-12-12T00:00:001996The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast.9710596Kadosh D, Struhl KMolecular and cellular biologyTargeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo. Mol Cell Biol. 1998 Sep; 18(9):5121-7.Mol Cell Biol1998-09-01T00:00:001998Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo.9822614Benson JD, Benson M, Howley PM, Struhl KThe EMBO journalAssociation of distinct yeast Not2 functional domains with components of Gcn5 histone acetylase and Ccr4 transcriptional regulatory complexes. EMBO J. 1998 Nov 16; 17(22):6714-22.EMBO J1998-11-16T00:00:001998Association of distinct yeast Not2 functional domains with components of Gcn5 histone acetylase and Ccr4 transcriptional regulatory complexes.10336691Keaveney M, Struhl KGenes to cells : devoted to molecular & cellular mechanismsIncorporation of Drosophila TAF110 into the yeast TFIID complex does not permit the Sp1 glutamine-rich activation domain to function in vivo. Genes Cells. 1999 Apr; 4(4):197-203.Genes Cells1999-04-01T00:00:001999Incorporation of Drosophila TAF110 into the yeast TFIID complex does not permit the Sp1 glutamine-rich activation domain to function in vivo.10376605Kuras L, Struhl KNatureBinding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme. Nature. 1999 Jun 10; 399(6736):609-13.Nature1999-06-10T00:00:001999Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme.1739977Strubin M, Struhl KCellYeast and human TFIID with altered DNA-binding specificity for TATA elements. Cell. 1992 Feb 21; 68(4):721-30.Cell1992-02-21T00:00:001992Yeast and human TFIID with altered DNA-binding specificity for TATA elements.15466047Grainger DC, Overton TW, Reppas N, Wade JT, Tamai E, Hobman JL, Constantinidou C, Struhl K, Church G, Busby SJJournal of bacteriologyGenomic studies with Escherichia coli MelR protein: applications of chromatin immunoprecipitation and microarrays. J Bacteriol. 2004 Oct; 186(20):6938-43.J Bacteriol2004-10-01T00:00:002004Genomic studies with Escherichia coli MelR protein: applications of chromatin immunoprecipitation and microarrays.17022824Ghosh S, Hirsch HA, Sekinger E, Struhl K, Gingeras TRBMC bioinformaticsRank-statistics based enrichment-site prediction algorithm developed for chromatin immunoprecipitation on chip experiments. BMC Bioinformatics. 2006 Oct 05; 7:434.BMC Bioinformatics2006-10-05T00:00:002006Rank-statistics based enrichment-site prediction algorithm developed for chromatin immunoprecipitation on chip experiments.9674419Struhl K, Moqtaderi ZCellThe TAFs in the HAT. Cell. 1998 Jul 10; 94(1):1-4.Cell1998-07-10T00:00:001998The TAFs in the HAT.11158301Mencía M, Struhl KMolecular and cellular biologyRegion of yeast TAF 130 required for TFIID to associate with promoters. 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Cell. 2004 Feb 20; 116(4):499-509.Cell2004-02-20T00:00:002004Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs.15335771Struhl KCurrent biology : CBGene expression: chromatin and transcription factors: who's on first? Curr Biol. 1993 Apr 01; 3(4):220-2.Curr Biol1993-04-01T00:00:001993Gene expression: chromatin and transcription factors: who's on first?15920479Katan-Khaykovich Y, Struhl KThe EMBO journalHeterochromatin formation involves changes in histone modifications over multiple cell generations. EMBO J. 2005 Jun 15; 24(12):2138-49.EMBO J2005-05-26T00:00:002005Heterochromatin formation involves changes in histone modifications over multiple cell generations.10924455Lee M, Chatterjee S, Struhl KGeneticsGenetic analysis of the role of Pol II holoenzyme components in repression by the Cyc8-Tup1 corepressor in yeast. 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Mol Cell Biol. 2000 Jun; 20(12):4350-8.Mol Cell Biol2000-06-01T00:00:002000Artificial recruitment of TFIID, but not RNA polymerase II holoenzyme, activates transcription in mammalian cells.16880509Miotto B, Struhl KMolecular and cellular biologyDifferential gene regulation by selective association of transcriptional coactivators and bZIP DNA-binding domains. Mol Cell Biol. 2006 Aug; 26(16):5969-82.Mol Cell Biol2006-08-01T00:00:002006Differential gene regulation by selective association of transcriptional coactivators and bZIP DNA-binding domains.17277804Struhl KNature structural & molecular biologyTranscriptional noise and the fidelity of initiation by RNA polymerase II. Nat Struct Mol Biol. 2007 Feb; 14(2):103-5.Nat Struct Mol Biol2007-02-01T00:00:002007Transcriptional noise and the fidelity of initiation by RNA polymerase II.1542572Pu WT, Struhl KNucleic acids researchUracil interference, a rapid and general method for defining protein-DNA interactions involving the 5-methyl group of thymines: the GCN4-DNA complex. Nucleic Acids Res. 1992 Feb 25; 20(4):771-5.Nucleic Acids Res1992-02-25T00:00:001992Uracil interference, a rapid and general method for defining protein-DNA interactions involving the 5-methyl group of thymines: the GCN4-DNA complex.18265225Struhl KCurrent protocols in molecular biologySubcloning of DNA fragments. Curr Protoc Mol Biol. 2001 May; Chapter 3:Unit3.16.Curr Protoc Mol Biol2001-05-01T00:00:002001Subcloning of DNA fragments.19752085Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl KCancer researchMetformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res. 2009 Oct 01; 69(19):7507-11.Cancer Res2009-09-14T00:00:002009Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission.20418883Moqtaderi Z, Wang J, Raha D, White RJ, Snyder M, Weng Z, Struhl KNature structural & molecular biologyGenomic binding profiles of functionally distinct RNA polymerase III transcription complexes in human cells. Nat Struct Mol Biol. 2010 May; 17(5):635-40.Nat Struct Mol Biol2010-04-25T00:00:002010Genomic binding profiles of functionally distinct RNA polymerase III transcription complexes in human cells.11498564Struhl KScience (New York, N.Y.)Gene regulation. A paradigm for precision. Science. 2001 Aug 10; 293(5532):1054-5.Science2001-08-10T00:00:002001Gene regulation. A paradigm for precision.9150136Kadosh D, Struhl KCellRepression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell. 1997 May 02; 89(3):365-71.Cell1997-05-02T00:00:001997Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters.9185851Mahadevan S, Raghunand TR, Panicker S, Struhl KGeneCharacterisation of 3' end formation of the yeast HIS3 mRNA. Gene. 1997 Apr 29; 190(1):69-76.Gene1997-04-29T00:00:001997Characterisation of 3' end formation of the yeast HIS3 mRNA.9372910Chou S, Struhl KMolecular and cellular biologyTranscriptional activation by TFIIB mutants that are severely impaired in interaction with promoter DNA and acidic activation domains. Mol Cell Biol. 1997 Dec; 17(12):6794-802.Mol Cell Biol1997-12-01T00:00:001997Transcriptional activation by TFIIB mutants that are severely impaired in interaction with promoter DNA and acidic activation domains.10330135Ranallo RT, Struhl K, Stargell LAMolecular and cellular biologyA TATA-binding protein mutant defective for TFIID complex formation in vivo. Mol Cell Biol. 1999 Jun; 19(6):3951-7.Mol Cell Biol1999-06-01T00:00:001999A TATA-binding protein mutant defective for TFIID complex formation in vivo.12086627Proft M, Struhl KMolecular cellHog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress. Mol Cell. 2002 Jun; 9(6):1307-17.Mol Cell2002-06-01T00:00:002002Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress.16364921Joshi AA, Struhl KMolecular cellEaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation. Mol Cell. 2005 Dec 22; 20(6):971-8.Mol Cell2005-12-22T00:00:002005Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation.17581117Wade JT, Struhl K, Busby SJ, Grainger DCMolecular microbiologyGenomic analysis of protein-DNA interactions in bacteria: insights into transcription and chromosome organization. Mol Microbiol. 2007 Jul; 65(1):21-6.Mol Microbiol2007-07-01T00:00:002007Genomic analysis of protein-DNA interactions in bacteria: insights into transcription and chromosome organization.12167634Ng HH, Xu RM, Zhang Y, Struhl KThe Journal of biological chemistryUbiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79. J Biol Chem. 2002 Sep 20; 277(38):34655-7.J Biol Chem2002-08-06T00:00:002002Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.12876293Ng HH, Dole S, Struhl KThe Journal of biological chemistryThe Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B. J Biol Chem. 2003 Sep 05; 278(36):33625-8.J Biol Chem2003-07-21T00:00:002003The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B.15520460Geisberg JV, Struhl KNucleic acids researchQuantitative sequential chromatin immunoprecipitation, a method for analyzing co-occupancy of proteins at genomic regions in vivo. Nucleic Acids Res. 2004 Nov 01; 32(19):e151.Nucleic Acids Res2004-11-01T00:00:002004Quantitative sequential chromatin immunoprecipitation, a method for analyzing co-occupancy of proteins at genomic regions in vivo.10669725Geisberg JV, Struhl KMolecular and cellular biologyTATA-binding protein mutants that increase transcription from enhancerless and repressed promoters in vivo. Mol Cell Biol. 2000 Mar; 20(5):1478-88.Mol Cell Biol2000-03-01T00:00:002000TATA-binding protein mutants that increase transcription from enhancerless and repressed promoters in vivo.12080090Ng HH, Feng Q, Wang H, Erdjument-Bromage H, Tempst P, Zhang Y, Struhl KGenes & developmentLysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association. Genes Dev. 2002 Jun 15; 16(12):1518-27.Genes Dev2002-06-15T00:00:002002Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.21555366Polytarchou C, Iliopoulos D, Hatziapostolou M, Kottakis F, Maroulakou I, Struhl K, Tsichlis PNCancer researchAkt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation. Cancer Res. 2011 Jul 01; 71(13):4720-31.Cancer Res2011-05-09T00:00:002011Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation.2828877Oliphant AR, Struhl KMethods in enzymologyThe use of random-sequence oligonucleotides for determining consensus sequences. Methods Enzymol. 1987; 155:568-82.Methods Enzymol1987-01-01T00:00:001987The use of random-sequence oligonucleotides for determining consensus sequences.21695216Esberg A, Moqtaderi Z, Fan X, Lu J, Struhl K, Byström APloS oneIwr1 protein is important for preinitiation complex formation by all three nuclear RNA polymerases in Saccharomyces cerevisiae. PLoS One. 2011; 6(6):e20829.PLoS One2011-06-10T00:00:002011Iwr1 protein is important for preinitiation complex formation by all three nuclear RNA polymerases in Saccharomyces cerevisiae.2882858Struhl KCellPromoters, activator proteins, and the mechanism of transcriptional initiation in yeast. Cell. 1987 May 08; 49(3):295-7.Cell1987-05-08T00:00:001987Promoters, activator proteins, and the mechanism of transcriptional initiation in yeast.2188101Ponticelli AS, Struhl KMolecular and cellular biologyAnalysis of Saccharomyces cerevisiae his3 transcription in vitro: biochemical support for multiple mechanisms of transcription. Mol Cell Biol. 1990 Jun; 10(6):2832-9.Mol Cell Biol1990-06-01T00:00:001990Analysis of Saccharomyces cerevisiae his3 transcription in vitro: biochemical support for multiple mechanisms of transcription.2015628Cormack BP, Strubin M, Ponticelli AS, Struhl KCellFunctional differences between yeast and human TFIID are localized to the highly conserved region. Cell. 1991 Apr 19; 65(2):341-8.Cell1991-04-19T00:00:001991Functional differences between yeast and human TFIID are localized to the highly conserved region.12417716Geisberg JV, Moqtaderi Z, Kuras L, Struhl KMolecular and cellular biologyMot1 associates with transcriptionally active promoters and inhibits association of NC2 in Saccharomyces cerevisiae. Mol Cell Biol. 2002 Dec; 22(23):8122-34.Mol Cell Biol2002-12-01T00:00:002002Mot1 associates with transcriptionally active promoters and inhibits association of NC2 in Saccharomyces cerevisiae.18265086Baldwin AS, Oettinger M, Struhl KCurrent protocols in molecular biologyMethylation and uracil interference assays for analysis of protein-DNA interactions. Curr Protoc Mol Biol. 2001 May; Chapter 12:Unit 12.3.Curr Protoc Mol Biol2001-05-01T00:00:002001Methylation and uracil interference assays for analysis of protein-DNA interactions.18265231Tabor S, Struhl K, Scharf SJ, Gelfand DHCurrent protocols in molecular biologyDNA-dependent DNA polymerases. Curr Protoc Mol Biol. 2001 May; Chapter 3:Unit3.5.Curr Protoc Mol Biol2001-05-01T00:00:002001DNA-dependent DNA polymerases.18265359Geisberg JV, Struhl KCurrent protocols in molecular biologyAnalysis of protein co-occupancy by quantitative sequential chromatin immunoprecipitation. Curr Protoc Mol Biol. 2005 May; Chapter 21:Unit 21.8.Curr Protoc Mol Biol2005-05-01T00:00:002005Analysis of protein co-occupancy by quantitative sequential chromatin immunoprecipitation.1641337van Heeckeren WJ, Sellers JW, Struhl KNucleic acids researchRole of the conserved leucines in the leucine zipper dimerization motif of yeast GCN4. Nucleic Acids Res. 1992 Jul 25; 20(14):3721-4.Nucleic Acids Res1992-07-25T00:00:001992Role of the conserved leucines in the leucine zipper dimerization motif of yeast GCN4.11979277Strässer K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondón AG, Aguilera A, Struhl K, Reed R, Hurt ENatureTREX is a conserved complex coupling transcription with messenger RNA export. Nature. 2002 May 16; 417(6886):304-8.Nature2002-04-28T00:00:002002TREX is a conserved complex coupling transcription with messenger RNA export.10412974Struhl KCellFundamentally different logic of gene regulation in eukaryotes and prokaryotes. Cell. 1999 Jul 09; 98(1):1-4.Cell1999-07-09T00:00:001999Fundamentally different logic of gene regulation in eukaryotes and prokaryotes.11163204Reid JL, Iyer VR, Brown PO, Struhl KMolecular cellCoordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase. Mol Cell. 2000 Dec; 6(6):1297-307.Mol Cell2000-12-01T00:00:002000Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase.11163205Kuo MH, vom Baur E, Struhl K, Allis CDMolecular cellGcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription. 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Nature. 2004 Dec 23; 432(7020):1054-8.Nature2004-12-23T00:00:002004The transcription factor Ifh1 is a key regulator of yeast ribosomal protein genes.9844639Moqtaderi Z, Keaveney M, Struhl KMolecular cellThe histone H3-like TAF is broadly required for transcription in yeast. Mol Cell. 1998 Nov; 2(5):675-82.Mol Cell1998-11-01T00:00:001998The histone H3-like TAF is broadly required for transcription in yeast.18265057Struhl KCurrent protocols in molecular biologySynthesizing proteins in vitro by transcription and translation of cloned genes. Curr Protoc Mol Biol. 2001 May; Chapter 10:Unit 10.17.Curr Protoc Mol Biol2001-05-01T00:00:002001Synthesizing proteins in vitro by transcription and translation of cloned genes.18832628Madhani HD, Francis NJ, Kingston RE, Kornberg RD, Moazed D, Narlikar GJ, Panning B, Struhl KScience (New York, N.Y.)Epigenomics: a roadmap, but to where? 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Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9094-8.Proc Natl Acad Sci U S A1989-12-01T00:00:001989An efficient method for generating proteins with altered enzymatic properties: application to beta-lactamase.20644729Yang A, Zhu Z, Kettenbach A, Kapranov P, McKeon F, Gingeras TR, Struhl KPloS oneGenome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo. PLoS One. 2010 Jul 14; 5(7):e11572.PLoS One2010-07-14T00:00:002010Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo.21220302Katan-Khaykovich Y, Struhl KProceedings of the National Academy of Sciences of the United States of AmericaSplitting of H3-H4 tetramers at transcriptionally active genes undergoing dynamic histone exchange. 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Mol Cell. 2006 May 05; 22(3):415-22.Mol Cell2006-05-05T00:00:002006Asf1 mediates histone eviction and deposition during elongation by RNA polymerase II.18265221Tabor S, Struhl KCurrent protocols in molecular biologyEndonucleases. Curr Protoc Mol Biol. 2001 May; Chapter 3:Unit3.12.Curr Protoc Mol Biol2001-05-01T00:00:002001Endonucleases.8783941Stargell LA, Struhl KTrends in genetics : TIGMechanisms of transcriptional activation in vivo: two steps forward. Trends Genet. 1996 Aug; 12(8):311-5.Trends Genet1996-08-01T00:00:001996Mechanisms of transcriptional activation in vivo: two steps forward.3913566Struhl K, Chen W, Hill DE, Hope IA, Oettinger MACold Spring Harbor symposia on quantitative biologyConstitutive and coordinately regulated transcription of yeast genes: promoter elements, positive and negative regulatory sites, and DNA binding proteins. 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Proc Natl Acad Sci U S A. 1976 May; 73(5):1471-5.Proc Natl Acad Sci U S A1976-05-01T00:00:001976Functional genetic expression of eukaryotic DNA in Escherichia coli.6760196Struhl KProceedings of the National Academy of Sciences of the United States of AmericaThe yeast his3 promoter contains at least two distinct elements. Proc Natl Acad Sci U S A. 1982 Dec; 79(23):7385-9.Proc Natl Acad Sci U S A1982-12-01T00:00:001982The yeast his3 promoter contains at least two distinct elements.1922025Pu WT, Struhl KMolecular and cellular biologyHighly conserved residues in the bZIP domain of yeast GCN4 are not essential for DNA binding. Mol Cell Biol. 1991 Oct; 11(10):4918-26.Mol Cell Biol1991-10-01T00:00:001991Highly conserved residues in the bZIP domain of yeast GCN4 are not essential for DNA binding.18282700Wade JT, Struhl KCurrent opinion in genetics & developmentThe transition from transcriptional initiation to elongation. 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