Mallinckrodt Professor of Pathology, Emeritus
Pal S, Iruela-Arispe ML, Harvey VS, Zeng H, Nagy JA, Dvorak HF, Mukhopadhyay D
Retinoic acid selectively inhibits the vascular permeabilizing effect of VPF/VEGF, an early step in the angiogenic cascade. Microvasc Res. 2000 Sep; 60(2):112-20.
Retinoic acid selectively inhibits the vascular permeabilizing effect of VPF/VEGF, an early step in the angiogenic cascade.
Dvorak AM, Dickersin GR, Connell A, Carey RW, Dvorak HF
Degranulation mechanisms in human leukemic basophils. Clin Immunol Immunopathol. 1976 Mar; 5(2):235-46.
Degranulation mechanisms in human leukemic basophils.
Colvin RB, Pinn VW, Simpson BA, Dvorak HF
Journal of immunology (Baltimore, Md. : 1950)
Cutaneous basophil hypersensitivity. IV. The "late reaction": sequel to Jones-Mote type hypersensitivity. Comparison with rabbit Arthus reaction. Effect of passive antibody on induction and expression of Jones-Mote hypersensitivity. J Immunol. 1973 May; 110(5):1279-89.
Cutaneous basophil hypersensitivity. IV. The "late reaction": sequel to Jones-Mote type hypersensitivity. Comparison with rabbit Arthus reaction. Effect of passive antibody on induction and expression of Jones-Mote hypersensitivity.
0bituary: Dr. Louis Dienes. J Infect Dis. 1974 Jul; 130(1):89-91.
Proceedings: Morphologic studies in cellular hypersensitivity in guinea pigs and man. Monogr Allergy. 1974; 8(0):54-65.
Proceedings: Morphologic studies in cellular hypersensitivity in guinea pigs and man.
Dvorak AM, Connell AB, Proppe K, Dvorak HF
Immunologic rejection of mammary adenocarcinoma (TA3-St) in C57BL/6 mice: participation of neutrophils and activated macrophages with fibrin formation. J Immunol. 1978 Apr; 120(4):1240-8.
Immunologic rejection of mammary adenocarcinoma (TA3-St) in C57BL/6 mice: participation of neutrophils and activated macrophages with fibrin formation.
deShazo RD, Griffing C, Kwan TH, Banks WA, Dvorak HF
The Journal of allergy and clinical immunology
Dermal hypersensitivity reactions to imported fire ants. J Allergy Clin Immunol. 1984 Dec; 74(6):841-7.
Dermal hypersensitivity reactions to imported fire ants.
Dvorak AM, Galli SJ, Schulman ES, Lichtenstein LM, Dvorak HF
Basophil and mast cell degranulation: ultrastructural analysis of mechanisms of mediator release. Fed Proc. 1983 May 15; 42(8):2510-5.
Basophil and mast cell degranulation: ultrastructural analysis of mechanisms of mediator release.
Why are tumour blood vessels abnormal and why is it important to know? Br J Cancer. 2009 Mar 24; 100(6):865-9.
Why are tumour blood vessels abnormal and why is it important to know?
Heterogeneity of the cellular immune response. I. Kinetics of lymphocyte stimulation during sensitization and recovery from tolerance. J Exp Med. 1971 Feb 01; 133(2):187-201.
Heterogeneity of the cellular immune response. I. Kinetics of lymphocyte stimulation during sensitization and recovery from tolerance.
Dvorak HF, Simpson BA, Flax MH, Leskowitz S
The fate of antigen in delayed hypersensitivity skin reactions. J Immunol. 1970 Mar; 104(3):718-27.
The fate of antigen in delayed hypersensitivity skin reactions.
Cutaneous necrotizing venulitis: a sequential analysis of the morphological alterations occurring after mast cell degranulation in a patient with a unique syndrome. Clin Exp Immunol. 1978 Apr; 32(1):46-58.
Cutaneous necrotizing venulitis: a sequential analysis of the morphological alterations occurring after mast cell degranulation in a patient with a unique syndrome.
Clark RA, Lanigan JM, DellaPelle P, Manseau E, Dvorak HF, Colvin RB
The Journal of investigative dermatology
Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reepithelialization. J Invest Dermatol. 1982 Nov; 79(5):264-9.
Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reepithelialization.
Brown LF, Olbricht SM, Berse B, Jackman RW, Matsueda G, Tognazzi KA, Manseau EJ, Dvorak HF, Van de Water L
Overexpression of vascular permeability factor (VPF/VEGF) and its endothelial cell receptors in delayed hypersensitivity skin reactions. J Immunol. 1995 Mar 15; 154(6):2801-7.
Overexpression of vascular permeability factor (VPF/VEGF) and its endothelial cell receptors in delayed hypersensitivity skin reactions.
Angiogenesis: a dynamic balance of stimulators and inhibitors. Thromb Haemost. 1997 Jul; 78(1):672-7.
Angiogenesis: a dynamic balance of stimulators and inhibitors.
Feng D, Nagy JA, Hipp J, Pyne K, Dvorak HF, Dvorak AM
Reinterpretation of endothelial cell gaps induced by vasoactive mediators in guinea-pig, mouse and rat: many are transcellular pores. J Physiol. 1997 Nov 01; 504 ( Pt 3):747-61.
Reinterpretation of endothelial cell gaps induced by vasoactive mediators in guinea-pig, mouse and rat: many are transcellular pores.
Sioussat TM, Dvorak HF, Brock TA, Senger DR
Inhibition of vascular permeability factor (vascular endothelial growth factor) with antipeptide antibodies. Arch Biochem Biophys. 1993 Feb 15; 301(1):15-20.
Inhibition of vascular permeability factor (vascular endothelial growth factor) with antipeptide antibodies.
Brown LF, Tognazzi K, Dvorak HF, Harrist TJ
Strong expression of kinase insert domain-containing receptor, a vascular permeability factor/vascular endothelial growth factor receptor in AIDS-associated Kaposi's sarcoma and cutaneous angiosarcoma. Am J Pathol. 1996 Apr; 148(4):1065-74.
Strong expression of kinase insert domain-containing receptor, a vascular permeability factor/vascular endothelial growth factor receptor in AIDS-associated Kaposi's sarcoma and cutaneous angiosarcoma.
McCarty JH, Monahan-Earley RA, Brown LF, Keller M, Gerhardt H, Rubin K, Shani M, Dvorak HF, Wolburg H, Bader BL, Dvorak AM, Hynes RO
Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins. Mol Cell Biol. 2002 Nov; 22(21):7667-77.
Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins.
Cao Y, Arbiser J, D'Amato RJ, D'Amore PA, Ingber DE, Kerbel R, Klagsbrun M, Lim S, Moses MA, Zetter B, Dvorak H, Langer R
Forty-year journey of angiogenesis translational research. Sci Transl Med. 2011 Dec 21; 3(114):114rv3.
Forty-year journey of angiogenesis translational research.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Localization of skeletal muscle phosphorylase using a fluorescent antibody technique and its correlation with histochemical observations. J Histochem Cytochem. 1965 Jul-Aug; 13(6):454-60.
Localization of skeletal muscle phosphorylase using a fluorescent antibody technique and its correlation with histochemical observations.
T cell subsets in allograft rejection. In situ characterization of T cell subsets in human skin allografts by the use of monoclonal antibodies. J Immunol. 1982 Oct; 129(4):1578-83.
T cell subsets in allograft rejection. In situ characterization of T cell subsets in human skin allografts by the use of monoclonal antibodies.
Dvorak HF, Quay SC, Orenstein NS, Dvorak AM, Hahn P, Bitzer AM, Carvalho AC
Tumor shedding and coagulation. Science. 1981 May 22; 212(4497):923-4.
The structure of normal skin and the morphology of atopic eczema. J Invest Dermatol. 1976 Sep; 67(3):305-12.
The structure of normal skin and the morphology of atopic eczema.
Wada Y, Li D, Merley A, Zukauskas A, Aird WC, Dvorak HF, Shih SC
A multi-gene transcriptional profiling approach to the discovery of cell signature markers. Cytotechnology. 2011 Jan; 63(1):25-33.
A multi-gene transcriptional profiling approach to the discovery of cell signature markers.
DVORAK HF, BILLOTE JB, MCCARTHY JS, FLAX MH
IMMUNOLOGIC UNRESPONSIVENESS IN THE ADULT GUINEA PIG. I. SUPPRESSION OF DELAYED HYPERSENSITIVITY AND ANTIBODY FORMATION TO PROTEIN ANTIGENS. J Immunol. 1965 Jun; 94:966-75.
IMMUNOLOGIC UNRESPONSIVENESS IN THE ADULT GUINEA PIG. I. SUPPRESSION OF DELAYED HYPERSENSITIVITY AND ANTIBODY FORMATION TO PROTEIN ANTIGENS.
Sung C, Shockley TR, Morrison PF, Dvorak HF, Yarmush ML, Dedrick RL
Predicted and observed effects of antibody affinity and antigen density on monoclonal antibody uptake in solid tumors. Cancer Res. 1992 Jan 15; 52(2):377-84.
Predicted and observed effects of antibody affinity and antigen density on monoclonal antibody uptake in solid tumors.
Histamine and basophils in delayed-type hypersensitivity reactions. J Immunol. 1973 Jun; 110(6):1511-7.
Histamine and basophils in delayed-type hypersensitivity reactions.
Biochemical and cytochemical evidence for the polar concentration of periplasmic enzymes in a "minicell" strain of Escherichia coli. J Bacteriol. 1970 Oct; 104(1):543-8.
Biochemical and cytochemical evidence for the polar concentration of periplasmic enzymes in a "minicell" strain of Escherichia coli.
Advances in experimental medicine and biology
Basophilic leukocytes in delayed-type hypersensitivity reactions in experimental animals and man. Adv Exp Med Biol. 1973; 29(0):573-9.
Basophilic leukocytes in delayed-type hypersensitivity reactions in experimental animals and man.
Basophils, mast cells, and cellular immunity in animals and man. Hum Pathol. 1972 Dec; 3(4):454-6.
Basophils, mast cells, and cellular immunity in animals and man.
Cytochemical localization of peroxidase activity in the developing erythrocyte. Am J Pathol. 1972 May; 67(2):303-26.
Cytochemical localization of peroxidase activity in the developing erythrocyte.
Dvorak AM, Galli SJ, Marcum JA, Nabel G, der Simonian H, Goldin J, Monahan RA, Pyne K, Cantor H, Rosenberg RD, Dvorak HF
Cloned mouse cells with natural killer function and cloned suppressor T cells express ultrastructural and biochemical features not shared by cloned inducer T cells. J Exp Med. 1983 Mar 01; 157(3):843-61.
Cloned mouse cells with natural killer function and cloned suppressor T cells express ultrastructural and biochemical features not shared by cloned inducer T cells.
Clark RA, Horsburgh CR, Hoffman AA, Dvorak HF, Mosesson MW, Colvin RB
Fibronectin deposition in delayed-type hypersensitivity. Reactions of normals and a patient with afibrinogenemia. J Clin Invest. 1984 Sep; 74(3):1011-6.
Fibronectin deposition in delayed-type hypersensitivity. Reactions of normals and a patient with afibrinogenemia.
McMaster PR, Owens JD, Dvorak HF, Weichbrod R, Asofsky R
Hapten-specific delayed hypersensitivity to epsilon-2,4-dinitrophenyl-L-lysine-Ficoll in guinea pigs immunized with 2,4-dinitrophenyl-keyhole limpet hemocyanin. J Exp Med. 1977 May 01; 145(5):1101-14.
Hapten-specific delayed hypersensitivity to epsilon-2,4-dinitrophenyl-L-lysine-Ficoll in guinea pigs immunized with 2,4-dinitrophenyl-keyhole limpet hemocyanin.
Thrombosis and cancer. Hum Pathol. 1987 Mar; 18(3):275-84.
Laboratory investigation; a journal of technical methods and pathology
The "transfer reaction" in the rabbit. II. A radioautographic study. Lab Invest. 1963 Jun; 12:628-37.
The "transfer reaction" in the rabbit. II. A radioautographic study.
Feng D, Nagy JA, Pyne K, Dvorak HF, Dvorak AM
Ultrastructural localization of platelet endothelial cell adhesion molecule (PECAM-1, CD31) in vascular endothelium. J Histochem Cytochem. 2004 Jan; 52(1):87-101.
Ultrastructural localization of platelet endothelial cell adhesion molecule (PECAM-1, CD31) in vascular endothelium.
Shockley TR, Lin K, Nagy JA, Tompkins RG, Dvorak HF, Yarmush ML
Annals of the New York Academy of Sciences
Penetration of tumor tissue by antibodies and other immunoproteins. Ann N Y Acad Sci. 1991; 618:367-82.
Penetration of tumor tissue by antibodies and other immunoproteins.
Vascular permeability to plasma, plasma proteins, and cells: an update. Curr Opin Hematol. 2010 May; 17(3):225-9.
Vascular permeability to plasma, plasma proteins, and cells: an update.
My friend Marty. J Cutan Pathol. 2010 Apr; 37 Suppl 1:6-7.
Dvorak HF, Weaver VM, Tlsty TD, Bergers G
Tumor microenvironment and progression. J Surg Oncol. 2011 May 01; 103(6):468-74.
Immunologic unresponsiveness in the adult guinea pig. IV. Induction of unresponsiveness with aggregated serum proteins. J Immunol. 1969 May; 102(5):1163-71.
Immunologic unresponsiveness in the adult guinea pig. IV. Induction of unresponsiveness with aggregated serum proteins.
Colvin RB, Johnson RA, Mihm MC, Dvorak HF
Role of the clotting system in cell-mediated hypersensitivity. I. Fibrin deposition in delayed skin reactions in man. J Exp Med. 1973 Sep 01; 138(3):686-98.
Role of the clotting system in cell-mediated hypersensitivity. I. Fibrin deposition in delayed skin reactions in man.
Dvorak HF, Hammond ME, Colvin RB, Manseau EJ, Goodwin J
Systemic expression of cutaneous basophil hypersensitivity. J Immunol. 1977 May; 118(5):1549-57.
Systemic expression of cutaneous basophil hypersensitivity.
Biochemical and biophysical research communications
The occurrence of a protein inhibitor for 5'-nucleotidase in extracts of Escherichia coli. Biochem Biophys Res Commun. 1966 Sep 08; 24(5):628-32.
The occurrence of a protein inhibitor for 5'-nucleotidase in extracts of Escherichia coli.
Fibronectin in delayed-type hypersensitivity skin reactions: associations with vessel permeability and endothelial cell activation. J Immunol. 1981 Feb; 126(2):787-93.
Fibronectin in delayed-type hypersensitivity skin reactions: associations with vessel permeability and endothelial cell activation.
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med. 1986 Dec 25; 315(26):1650-9.
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
Senger DR, Perruzzi CA, Feder J, Dvorak HF
A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res. 1986 Nov; 46(11):5629-32.
A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines.
Basophilic leukocytes in a case of poison ivy. N Engl J Med. 1971 Jul 01; 285(1):54-5.
Basophilic leukocytes in a case of poison ivy.
Galli SJ, Colvin RB, Verderber E, Galli AS, Monahan R, Dvorak AM, Dvorak HF
Preparation of a rabbit anti-guinea pig basophil serum: in vitro and in vivo characterization. J Immunol. 1978 Sep; 121(3):1157-66.
Preparation of a rabbit anti-guinea pig basophil serum: in vitro and in vivo characterization.
deShazo RD, Boehm TM, Kumar D, Galloway JA, Dvorak HF
Dermal hypersensitivity reactions to insulin: correlations of three patterns to their histopathology. J Allergy Clin Immunol. 1982 Feb; 69(2):229-37.
Dermal hypersensitivity reactions to insulin: correlations of three patterns to their histopathology.
Kamat BR, Brown LF, Manseau EJ, Senger DR, Dvorak HF
Expression of vascular permeability factor/vascular endothelial growth factor by human granulosa and theca lutein cells. Role in corpus luteum development. Am J Pathol. 1995 Jan; 146(1):157-65.
Expression of vascular permeability factor/vascular endothelial growth factor by human granulosa and theca lutein cells. Role in corpus luteum development.
Dvorak HF, Detmar M, Claffey KP, Nagy JA, van de Water L, Senger DR
International archives of allergy and immunology
Vascular permeability factor/vascular endothelial growth factor: an important mediator of angiogenesis in malignancy and inflammation. Int Arch Allergy Immunol. 1995 May-Jun; 107(1-3):233-5.
Vascular permeability factor/vascular endothelial growth factor: an important mediator of angiogenesis in malignancy and inflammation.
Brown LF, Berse B, Jackman RW, Tognazzi K, Guidi AJ, Dvorak HF, Senger DR, Connolly JL, Schnitt SJ
Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Hum Pathol. 1995 Jan; 26(1):86-91.
Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer.
Dvorak AM, Kohn S, Morgan ES, Fox P, Nagy JA, Dvorak HF
The vesiculo-vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation. J Leukoc Biol. 1996 Jan; 59(1):100-15.
The vesiculo-vacuolar organelle (VVO): a distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation.
The American review of respiratory disease
Leaky vessels, fibrin deposition, and fibrosis: a sequence of events common to solid tumors and to many other types of disease. Am Rev Respir Dis. 1989 Oct; 140(4):1104-7.
Leaky vessels, fibrin deposition, and fibrosis: a sequence of events common to solid tumors and to many other types of disease.
Cold Spring Harbor perspectives in medicine
Vascular hyperpermeability, angiogenesis, and stroma generation. Cold Spring Harb Perspect Med. 2012 Feb; 2(2):a006544.
Vascular hyperpermeability, angiogenesis, and stroma generation.
Delayed-type hypersensitivity skin reactions in congenital afibrinogenemia lack fibrin deposition and induration. J Clin Invest. 1979 Jun; 63(6):1302-6.
Delayed-type hypersensitivity skin reactions in congenital afibrinogenemia lack fibrin deposition and induration.
Antibody enhances lymphocyte proliferation in guinea pigs immunized to express cutaneous basophil hypersensitivity. Cell Immunol. 1986 May; 99(2):354-63.
Antibody enhances lymphocyte proliferation in guinea pigs immunized to express cutaneous basophil hypersensitivity.
Basophils and mast cells: morphologic insights into their biology, secretory patterns, and function. Prog Allergy. 1984; 34:1-141.
Basophils and mast cells: morphologic insights into their biology, secretory patterns, and function.
Galli SJ, Bast RC, Bast BS, Isomura T, Zbar B, Rapp HJ, Dvorak HF
Bystander suppression of tumor growth: evidence that specific targets and bystanders are damaged by injury to a common microvasculature. J Immunol. 1982 Aug; 129(2):890-9.
Bystander suppression of tumor growth: evidence that specific targets and bystanders are damaged by injury to a common microvasculature.
Senger DR, Asch BB, Smith BD, Perruzzi CA, Dvorak HF
A secreted phosphoprotein marker for neoplastic transformation of both epithelial and fibroblastic cells. Nature. 1983 Apr 21; 302(5910):714-5.
A secreted phosphoprotein marker for neoplastic transformation of both epithelial and fibroblastic cells.
Morphology of delayed-type hypersensitivity reactions in man. J Invest Dermatol. 1976 Sep; 67(3):391-401.
Morphology of delayed-type hypersensitivity reactions in man.
Dvorak AM, Weller PF, Harvey VS, Morgan ES, Dvorak HF
Ultrastructural localization of prostaglandin endoperoxide synthase (cyclooxygenase) to isolated, purified fractions of guinea pig peritoneal macrophage and line 10 hepatocarcinoma cell lipid bodies. Int Arch Allergy Immunol. 1993; 101(2):136-42.
Ultrastructural localization of prostaglandin endoperoxide synthase (cyclooxygenase) to isolated, purified fractions of guinea pig peritoneal macrophage and line 10 hepatocarcinoma cell lipid bodies.
Guidi AJ, Abu-Jawdeh G, Tognazzi K, Dvorak HF, Brown LF
Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in endometrial carcinoma. Cancer. 1996 Aug 01; 78(3):454-60.
Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in endometrial carcinoma.
Fibronectin beneath reepithelializing epidermis in vivo: sources and significance. J Invest Dermatol. 1983 Jun; 80(1 Suppl):26s-30s.
Fibronectin beneath reepithelializing epidermis in vivo: sources and significance.
Ffrench-Constant C, Van de Water L, Dvorak HF, Hynes RO
Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat. J Cell Biol. 1989 Aug; 109(2):903-14.
Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat.
Sitohy B, Nagy JA, Jaminet SC, Dvorak HF
Tumor-surrogate blood vessel subtypes exhibit differential susceptibility to anti-VEGF therapy. Cancer Res. 2011 Nov 15; 71(22):7021-8.
Tumor-surrogate blood vessel subtypes exhibit differential susceptibility to anti-VEGF therapy.
Specificity of basophils and lymphocytes in cutaneous basophil hypersensitivity. J Immunol. 1975 Jan; 114(1 Pt 2):507-11.
Specificity of basophils and lymphocytes in cutaneous basophil hypersensitivity.
Nagy JA, Herzberg KT, Masse EM, Zientara GP, Dvorak HF
Exchange of macromolecules between plasma and peritoneal cavity in ascites tumor-bearing, normal, and serotonin-injected mice. Cancer Res. 1989 Oct 01; 49(19):5448-58.
Exchange of macromolecules between plasma and peritoneal cavity in ascites tumor-bearing, normal, and serotonin-injected mice.
Heterogeneity of the tumor vasculature: the need for new tumor blood vessel type-specific targets. Clin Exp Metastasis. 2012 Oct; 29(7):657-62.
Heterogeneity of the tumor vasculature: the need for new tumor blood vessel type-specific targets.
Dvorak AM, Hammond ME, Dvorak HF, Karnovsky MJ
Loss of cell surface material from peritoneal exudate cells associated with lymphocyte-mediated inhibition of macrophage migration from capillary tubes. Lab Invest. 1972 Dec; 27(6):561-74.
Loss of cell surface material from peritoneal exudate cells associated with lymphocyte-mediated inhibition of macrophage migration from capillary tubes.
Basophilic leukocytes in allergic contact dermatitis. J Exp Med. 1972 Feb 01; 135(2):235-54.
Basophilic leukocytes in allergic contact dermatitis.
Dvorak HF, Simpson BA, Bast RC, Leskowitz S
Cutaneous basophil hypersensitivity. 3. Participation of the basophil in hypersensitivity to antigen-antibody complexes, delayed hypersensitivity and contact allergy. Passive transfer. J Immunol. 1971 Jul; 107(1):138-48.
Cutaneous basophil hypersensitivity. 3. Participation of the basophil in hypersensitivity to antigen-antibody complexes, delayed hypersensitivity and contact allergy. Passive transfer.
Dvorak AM, Galli SJ, Morgan E, Galli AS, Hammond ME, Dvorak HF
Anaphylactic degranulation of guinea pig basophilic leukocytes. I. Fusion of granule membranes and cytoplasmic vesicles formation and resolution of degranulation sacs. Lab Invest. 1981 Feb; 44(2):174-91.
Anaphylactic degranulation of guinea pig basophilic leukocytes. I. Fusion of granule membranes and cytoplasmic vesicles formation and resolution of degranulation sacs.
Dvorak AM, Dvorak HF, Peters SP, Shulman ES, MacGlashan DW, Pyne K, Harvey VS, Galli SJ, Lichtenstein LM
Lipid bodies: cytoplasmic organelles important to arachidonate metabolism in macrophages and mast cells. J Immunol. 1983 Dec; 131(6):2965-76.
Lipid bodies: cytoplasmic organelles important to arachidonate metabolism in macrophages and mast cells.
Mouse mast cells and other granulated leukocyte clones. Ultrastructure of cloned mouse leukocytes. Monogr Allergy. 1983; 18:129-37.
Mouse mast cells and other granulated leukocyte clones. Ultrastructure of cloned mouse leukocytes.
Ultrastructural localization of nonspecific esterase activity in guinea pig and human monocytes, macrophages, and lymphocytes. Blood. 1981 Dec; 58(6):1089-99.
Ultrastructural localization of nonspecific esterase activity in guinea pig and human monocytes, macrophages, and lymphocytes.
Ward PA, Dvorak HF, Cohen S, Yoshida T, Data R, Selvaggio SS
Chemotaxis of basophils by lymphocyte-dependent and lymphocyte-independent mechanisms. J Immunol. 1975 May; 114(5):1523-31.
Chemotaxis of basophils by lymphocyte-dependent and lymphocyte-independent mechanisms.
Degranulation of basophilic leukocytes in allergic contact dermatitis reactions in man. J Immunol. 1976 Mar; 116(3):687-95.
Degranulation of basophilic leukocytes in allergic contact dermatitis reactions in man.
Nagy JA, Meyers MS, Masse EM, Herzberg KT, Dvorak HF
Pathogenesis of ascites tumor growth: fibrinogen influx and fibrin accumulation in tissues lining the peritoneal cavity. Cancer Res. 1995 Jan 15; 55(2):369-75.
Pathogenesis of ascites tumor growth: fibrinogen influx and fibrin accumulation in tissues lining the peritoneal cavity.
Introduction--heterogeneity of the cellular immune response. Adv Exp Med Biol. 1979; 114:369-74.
Introduction--heterogeneity of the cellular immune response.
Dvorak AM, Galli SJ, Galli AS, Hammond ME, Churchill WH, Dvorak HF
Tumor-basophil interactions in vitro--a scanning and transmission electron microscopic study. J Immunol. 1979 Jun; 122(6):2447-57.
Tumor-basophil interactions in vitro--a scanning and transmission electron microscopic study.
Dvorak AM, Monahan-Earley RA, Dvorak HF, Galli SJ
Ultrastructural cytochemical and autoradiographic demonstration of nonspecific esterase(s) in guinea pig basophils. J Histochem Cytochem. 1987 Mar; 35(3):351-60.
Ultrastructural cytochemical and autoradiographic demonstration of nonspecific esterase(s) in guinea pig basophils.
Heterogeneity of the cellular immune response. II. The role of adjuvant, lymphocyte stimulation in cutaneous basophil hypersensitivity. J Exp Med. 1971 Feb 01; 133(2):202-15.
Heterogeneity of the cellular immune response. II. The role of adjuvant, lymphocyte stimulation in cutaneous basophil hypersensitivity.
Dvorak HF, Van DeWater L, Bitzer AM, Dvorak AM, Anderson D, Harvey VS, Bach R, Davis GL, DeWolf W, Carvalho AC
Procoagulant activity associated with plasma membrane vesicles shed by cultured tumor cells. Cancer Res. 1983 Sep; 43(9):4434-42.
Procoagulant activity associated with plasma membrane vesicles shed by cultured tumor cells.
Galli SJ, Dvorak AM, Hammond ME, Morgan E, Galli AS, Dvorak HF
Guinea pig basophil morphology in vitro. I. Ultrastructure of uropod-bearing (motile) basophils and modulation of motile structures by serum and substrate effects. J Immunol. 1981 Mar; 126(3):1066-74.
Guinea pig basophil morphology in vitro. I. Ultrastructure of uropod-bearing (motile) basophils and modulation of motile structures by serum and substrate effects.
Fava RA, Olsen NJ, Spencer-Green G, Yeo KT, Yeo TK, Berse B, Jackman RW, Senger DR, Dvorak HF, Brown LF
Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J Exp Med. 1994 Jul 01; 180(1):341-6.
Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue.
Lin K, Nagy JA, Xu H, Shockley TR, Yarmush ML, Dvorak HF
Compartmental distribution of tumor-specific monoclonal antibodies in human melanoma xenografts. Cancer Res. 1994 Apr 15; 54(8):2269-77.
Compartmental distribution of tumor-specific monoclonal antibodies in human melanoma xenografts.
Journal of the National Cancer Institute
Microvascular injury in pathogenesis of interferon-induced necrosis of subcutaneous tumors in mice. J Natl Cancer Inst. 1989 Apr 05; 81(7):497-502.
Microvascular injury in pathogenesis of interferon-induced necrosis of subcutaneous tumors in mice.
Anti-VEGF/VEGFR therapy for cancer: reassessing the target. Cancer Res. 2012 Apr 15; 72(8):1909-14.
Anti-VEGF/VEGFR therapy for cancer: reassessing the target.
Cellular and vascular manifestations of cell-mediated immunity. Hum Pathol. 1986 Feb; 17(2):122-37.
Cellular and vascular manifestations of cell-mediated immunity.
Antigen-induced stimulation of glucosamine incorporation by guinea pig peritoneal macrophages in delayed hypersensitivity. J Exp Med. 1972 Dec 01; 136(6):1518-32.
Antigen-induced stimulation of glucosamine incorporation by guinea pig peritoneal macrophages in delayed hypersensitivity.
Dvorak HF, Mihm MC, Dvorak AM, Barnes BA, Galli SJ
The microvasculature is the critical target of the immune response in vascularized skin allograft rejection. J Invest Dermatol. 1980 May; 74(5):280-4.
The microvasculature is the critical target of the immune response in vascularized skin allograft rejection.
Dvorak HF, Brown LF, Detmar M, Dvorak AM
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol. 1995 May; 146(5):1029-39.
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
Brown LF, Berse B, Jackman RW, Tognazzi K, Manseau EJ, Dvorak HF, Senger DR
Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas. Am J Pathol. 1993 Nov; 143(5):1255-62.
Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas.
Yeo TK, Nagy JA, Yeo KT, Dvorak HF, Toole BP
Increased hyaluronan at sites of attachment to mesentery by CD44-positive mouse ovarian and breast tumor cells. Am J Pathol. 1996 Jun; 148(6):1733-40.
Increased hyaluronan at sites of attachment to mesentery by CD44-positive mouse ovarian and breast tumor cells.
Feng D, Nagy JA, Pyne K, Hammel I, Dvorak HF, Dvorak AM
Microcirculation (New York, N.Y. : 1994)
Pathways of macromolecular extravasation across microvascular endothelium in response to VPF/VEGF and other vasoactive mediators. Microcirculation. 1999 Mar; 6(1):23-44.
Pathways of macromolecular extravasation across microvascular endothelium in response to VPF/VEGF and other vasoactive mediators.
Galli SJ, Dvorak AM, Marcum JA, Nabel G, Goldin JM, Rosenberg RD, Cantor H, Dvorak HF
Mouse mast cell clones: modulation of functional maturity in vitro. Monogr Allergy. 1983; 18:166-70.
Mouse mast cell clones: modulation of functional maturity in vitro.
Clark RA, DellaPelle P, Manseau E, Lanigan JM, Dvorak HF, Colvin RB
Blood vessel fibronectin increases in conjunction with endothelial cell proliferation and capillary ingrowth during wound healing. J Invest Dermatol. 1982 Nov; 79(5):269-76.
Blood vessel fibronectin increases in conjunction with endothelial cell proliferation and capillary ingrowth during wound healing.
Dvorak HF, Orenstein NS, Dvorak AM, Hammond ME, Roblin RO, Feder J, Schott CF, Goodwin J, Morgan E
Isolation of the cytoplasmic granules of guinea pig basophilic leukocytes: identification of esterase and protease activities. J Immunol. 1977 Jul; 119(1):38-46.
Isolation of the cytoplasmic granules of guinea pig basophilic leukocytes: identification of esterase and protease activities.
Miller JW, Adamis AP, Shima DT, D'Amore PA, Moulton RS, O'Reilly MS, Folkman J, Dvorak HF, Brown LF, Berse B
Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am J Pathol. 1994 Sep; 145(3):574-84.
Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model.
Nagy JA, Senger DR, Dvorak HF, Dvorak AM
Ultrastructural localization of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) to the abluminal plasma membrane and vesiculovacuolar organelles of tumor microvascular endothelium. J Histochem Cytochem. 1995 Apr; 43(4):381-9.
Ultrastructural localization of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) to the abluminal plasma membrane and vesiculovacuolar organelles of tumor microvascular endothelium.
Galli SJ, Galli AS, Dvorak AM, Dvorak HF
Metabolic studies of guinea pig basophilic leukocytes in short-term tissue culture. I. Measurement of histaminesynthesizing capacity by using an isotopic-thin layer chromatographic assay. J Immunol. 1976 Oct; 117(4):1085-92.
Metabolic studies of guinea pig basophilic leukocytes in short-term tissue culture. I. Measurement of histaminesynthesizing capacity by using an isotopic-thin layer chromatographic assay.
Senger DR, Van de Water L, Brown LF, Nagy JA, Yeo KT, Yeo TK, Berse B, Jackman RW, Dvorak AM, Dvorak HF
Vascular permeability factor (VPF, VEGF) in tumor biology. Cancer Metastasis Rev. 1993 Sep; 12(3-4):303-24.
Vascular permeability factor (VPF, VEGF) in tumor biology.
Abu-Jawdeh GM, Faix JD, Niloff J, Tognazzi K, Manseau E, Dvorak HF, Brown LF
Strong expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in ovarian borderline and malignant neoplasms. Lab Invest. 1996 Jun; 74(6):1105-15.
Strong expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in ovarian borderline and malignant neoplasms.
Satchi-Fainaro R, Mamluk R, Wang L, Short SM, Nagy JA, Feng D, Dvorak AM, Dvorak HF, Puder M, Mukhopadhyay D, Folkman J
Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin. Cancer Cell. 2005 Mar; 7(3):251-61.
Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin.
Dvorak AM, Hammond ME, Morgan E, Orenstein NS, Galli SJ, Dvorak HF
Evidence for a vesicular transport mechanism in guinea pig basophilic leukocytes. Lab Invest. 1980 Feb; 42(2):263-76.
Evidence for a vesicular transport mechanism in guinea pig basophilic leukocytes.
Nabel G, Galli SJ, Dvorak AM, Dvorak HF, Cantor H
Inducer T lymphocytes synthesize a factor that stimulates proliferation of cloned mast cells. Nature. 1981 May 28; 291(5813):332-4.
Inducer T lymphocytes synthesize a factor that stimulates proliferation of cloned mast cells.
Journal of the Reticuloendothelial Society
Quantitative measurements of neutral red uptake and excretion by mammalian cells. J Reticuloendothel Soc. 1980 Mar; 27(3):337-46.
Quantitative measurements of neutral red uptake and excretion by mammalian cells.
Locke SE, Ransil BJ, Covino NA, Toczydlowski J, Lohse CM, Dvorak HF, Arndt KA, Frankel FH
Failure of hypnotic suggestion to alter immune response to delayed-type hypersensitivity antigens. Ann N Y Acad Sci. 1987; 496:745-9.
Failure of hypnotic suggestion to alter immune response to delayed-type hypersensitivity antigens.
Circulating membrane vesicles in leukemic blood. Cancer Res. 1985 Nov; 45(11 Pt 2):5944-51.
Circulating membrane vesicles in leukemic blood.
Melanoma. An ultrastructural study of the host inflammatory and vascular responses. J Invest Dermatol. 1980 Nov; 75(5):388-93.
Melanoma. An ultrastructural study of the host inflammatory and vascular responses.
Brown LF, Harrist TJ, Yeo KT, Ståhle-Bäckdahl M, Jackman RW, Berse B, Tognazzi K, Dvorak HF, Detmar M
Increased expression of vascular permeability factor (vascular endothelial growth factor) in bullous pemphigoid, dermatitis herpetiformis, and erythema multiforme. J Invest Dermatol. 1995 May; 104(5):744-9.
Increased expression of vascular permeability factor (vascular endothelial growth factor) in bullous pemphigoid, dermatitis herpetiformis, and erythema multiforme.
Yeo KT, Wang HH, Nagy JA, Sioussat TM, Ledbetter SR, Hoogewerf AJ, Zhou Y, Masse EM, Senger DR, Dvorak HF
Vascular permeability factor (vascular endothelial growth factor) in guinea pig and human tumor and inflammatory effusions. Cancer Res. 1993 Jun 15; 53(12):2912-8.
Vascular permeability factor (vascular endothelial growth factor) in guinea pig and human tumor and inflammatory effusions.
VEGF-A and the induction of pathological angiogenesis. Annu Rev Pathol. 2007; 2:251-75.
VEGF-A and the induction of pathological angiogenesis.
Zhao D, Qin L, Bourbon PM, James L, Dvorak HF, Zeng H
Proceedings of the National Academy of Sciences of the United States of America
Orphan nuclear transcription factor TR3/Nur77 regulates microvessel permeability by targeting endothelial nitric oxide synthase and destabilizing endothelial junctions. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):12066-71.
Orphan nuclear transcription factor TR3/Nur77 regulates microvessel permeability by targeting endothelial nitric oxide synthase and destabilizing endothelial junctions.
Dvorak HF, Mihm MC, Dvorak AM, Barnes BA, Manseau EJ, Galli SJ
Rejection of first-set skin allografts in man. the microvasculature is the critical target of the immune response. J Exp Med. 1979 Aug 01; 150(2):322-37.
Rejection of first-set skin allografts in man. the microvasculature is the critical target of the immune response.
Soter NA, Mihm MC, Gigli I, Dvorak HF, Austen KF
Two distinct cellular patterns in cutaneous necrotizing angiitis. J Invest Dermatol. 1976 Jun; 66(6):344-50.
Two distinct cellular patterns in cutaneous necrotizing angiitis.
Basophilic leucocytes: structure, function and role in disease. Clin Haematol. 1975 Oct; 4(3):651-83.
Basophilic leucocytes: structure, function and role in disease.
125I-fibrin deposition in contact sensitivity reactions in the mouse. Sensitivity of the assay for quantitating reactions after active or passive sensitization. J Immunol. 1986 Mar 15; 136(6):2018-25.
125I-fibrin deposition in contact sensitivity reactions in the mouse. Sensitivity of the assay for quantitating reactions after active or passive sensitization.
International archives of allergy and applied immunology
Surface membrane traffic in guinea pig basophils exposed to cationic ferritin. Int Arch Allergy Appl Immunol. 1985; 77(1-2):267-73.
Surface membrane traffic in guinea pig basophils exposed to cationic ferritin.
Letter: Basophils and mast cells in renal allograft rejection. Lancet. 1974 Feb 09; 1(7850):212-4.
Letter: Basophils and mast cells in renal allograft rejection.
Wetzel BK, Spicer SS, Dvorak HF, Heppel LA
Cytochemical localization of certain phosphatases in Escherichia coli. J Bacteriol. 1970 Oct; 104(1):529-42.
Cytochemical localization of certain phosphatases in Escherichia coli.
Cutaneous basophil hypersensitivity. I. A new look at the Jones-Mote reaction, general characteristics. J Exp Med. 1970 Sep 01; 132(3):546-57.
Cutaneous basophil hypersensitivity. I. A new look at the Jones-Mote reaction, general characteristics.
Galli SJ, Colvin RB, Orenstein NS, Dvorak AM, Dvorak HF
Patients without basophils. Lancet. 1977 Aug 20; 2(8034):409.
A role for cytoplasmic vesicles in anaphylactic degranulation of guinea pig basophils. Int Arch Allergy Appl Immunol. 1981; 66 Suppl 1:234-8.
A role for cytoplasmic vesicles in anaphylactic degranulation of guinea pig basophils.
Schnitt SJ, Stillman IE, Owings DV, Kishimoto C, Dvorak HF, Abelmann WH
Myocardial fibrin deposition in experimental viral myocarditis that progresses to dilated cardiomyopathy. Circ Res. 1993 Apr; 72(4):914-20.
Myocardial fibrin deposition in experimental viral myocarditis that progresses to dilated cardiomyopathy.
Antigen-enhanced glucosamine incorporation by peritoneal macrophages in cell-mediated hypersensitivity. I. Studies on biology and mechanism. J Immunol. 1975 Oct; 115(4):914-21.
Antigen-enhanced glucosamine incorporation by peritoneal macrophages in cell-mediated hypersensitivity. I. Studies on biology and mechanism.
Dvorak HF, Nagy JA, Feng D, Brown LF, Dvorak AM
Current topics in microbiology and immunology
Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis. Curr Top Microbiol Immunol. 1999; 237:97-132.
Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis.
Alterations in proteoglycan synthesis common to healing wounds and tumors. Am J Pathol. 1991 Jun; 138(6):1437-50.
Alterations in proteoglycan synthesis common to healing wounds and tumors.
Nagy JA, Vasile E, Feng D, Sundberg C, Brown LF, Manseau EJ, Dvorak AM, Dvorak HF
Cold Spring Harbor symposia on quantitative biology
VEGF-A induces angiogenesis, arteriogenesis, lymphangiogenesis, and vascular malformations. Cold Spring Harb Symp Quant Biol. 2002; 67:227-37.
VEGF-A induces angiogenesis, arteriogenesis, lymphangiogenesis, and vascular malformations.
Enzymatic inactivation of immunologically competent lyph node cells in the "transfer reaction". J Immunol. 1962 Oct; 89:571-81.
Enzymatic inactivation of immunologically competent lyph node cells in the "transfer reaction".
Hammond ME, Dvorak AM, Roblin RO, Morgan ES, Dvorak HF
Effect of E-amino caproic acid on macrohage cell coat and migration inhibtion. J Reticuloendothel Soc. 1978 Jul; 24(1):63-72.
Effect of E-amino caproic acid on macrohage cell coat and migration inhibtion.
Brown LF, Asch B, Harvey VS, Buchinski B, Dvorak HF
Fibrinogen influx and accumulation of cross-linked fibrin in mouse carcinomas. Cancer Res. 1988 Apr 01; 48(7):1920-5.
Fibrinogen influx and accumulation of cross-linked fibrin in mouse carcinomas.
Immunologic rejection of diethylnitrosamine-induced hepatomas in strain 2 guinea pigs: participation of basophilic leukocytes and macrophage aggregates. J Exp Med. 1973 Mar 01; 137(3):751-75.
Immunologic rejection of diethylnitrosamine-induced hepatomas in strain 2 guinea pigs: participation of basophilic leukocytes and macrophage aggregates.
Cutaneous basophilic hypersensitivity: a new interpretation of the Jones-Mote reaction. J Immunol. 1969 Dec; 103(6):1431-4.
Cutaneous basophilic hypersensitivity: a new interpretation of the Jones-Mote reaction.
Galli SJ, Dvorak AM, Marcum JA, Ishizaka T, Nabel G, Der Simonian H, Pyne K, Goldin JM, Rosenberg RD, Cantor H, Dvorak HF
Mast cell clones: a model for the analysis of cellular maturation. J Cell Biol. 1982 Nov; 95(2 Pt 1):435-44.
Mast cell clones: a model for the analysis of cellular maturation.
Anaphylactic degranulation of guinea pig basophilic leukocytes. II. Evidence for regranulation of mature basophils during recovery from degranulation in vitro. Lab Invest. 1982 May; 46(5):461-75.
Anaphylactic degranulation of guinea pig basophilic leukocytes. II. Evidence for regranulation of mature basophils during recovery from degranulation in vitro.
Letter: Cause of induration in skin tests (cont.). N Engl J Med. 1976 Sep 23; 295(13):734-5.
Letter: Cause of induration in skin tests (cont.).
Morphology of delayed-type hypersensitivity reactions in man. II. Ultrastructural alterations affecting the microvasculature and the tissue mast cells. Lab Invest. 1976 Feb; 34(2):179-91.
Morphology of delayed-type hypersensitivity reactions in man. II. Ultrastructural alterations affecting the microvasculature and the tissue mast cells.
William Bosworth Castle Professor of Medicine , Emeritus
Tumors: Wounds That Do Not Heal-A Historical Perspective with a Focus on the Fundamental Roles of Increased Vascular Permeability and Clotting. Semin Thromb Hemost. 2019 Sep; 45(6):576-592.
Tumors: Wounds That Do Not Heal-A Historical Perspective with a Focus on the Fundamental Roles of Increased Vascular Permeability and Clotting.
Charles L. Schepens Professor of Ophthalmology
Miriam H. Stoneman Professor of Radiology, Emeritus
Associate Professor of Radiation Oncology
Benjamin Castleman Distinguished Professor of Pathology
A. Werk Cook Professor of Radiation Oncology (Tumor Biology)
Frontiers in cell and developmental biology
Reconciling VEGF With VPF: The Importance of Increased Vascular Permeability for Stroma Formation in Tumors, Healing Wounds, and Chronic Inflammation. Front Cell Dev Biol. 2021; 9:660609.
Reconciling VEGF With VPF: The Importance of Increased Vascular Permeability for Stroma Formation in Tumors, Healing Wounds, and Chronic Inflammation.
Granulocytes (the red, white, and blue) in hypersensitivity reactions: A review. Inflammation. 1976 Mar; 1(2):127-41.
Granulocytes (the red, white, and blue) in hypersensitivity reactions: A review.
Rowe GC, Raghuram S, Jang C, Nagy JA, Patten IS, Goyal A, Chan MC, Liu LX, Jiang A, Spokes KC, Beeler D, Dvorak H, Aird WC, Arany Z
PGC-1a induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle. Circ Res. 2014 Aug 15; 115(5):504-17.
PGC-1a induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle.
Sadow PM, Priolo C, Nanni S, Karreth FA, Duquette M, Martinelli R, Husain A, Clohessy J, Kutzner H, Mentzel T, Carman CV, Farsetti A, Henske EP, Palescandolo E, Macconaill LE, Chung S, Fadda G, Lombardi CP, De Angelis AM, Durante O, Parker JA, Pontecorvi A, Dvorak HF, Fletcher C, Pandolfi PP, Lawler J, Nucera C
Role of BRAFV600E in the first preclinical model of multifocal infiltrating myopericytoma development and microenvironment. J Natl Cancer Inst. 2014 Aug; 106(8).
Role of BRAFV600E in the first preclinical model of multifocal infiltrating myopericytoma development and microenvironment.
Lin CI, Merley A, Sciuto TE, Li D, Dvorak AM, Melero-Martin JM, Dvorak HF, Jaminet SC
TM4SF1: a new vascular therapeutic target in cancer. Angiogenesis. 2014 Oct; 17(4):897-907.
TM4SF1: a new vascular therapeutic target in cancer.
Tumors: wounds that do not heal-redux. Cancer Immunol Res. 2015 Jan; 3(1):1-11.
Tumor Stroma, Tumor Blood Vessels, and Antiangiogenesis Therapy. Cancer J. 2015 Jul-Aug; 21(4):237-43.
Tumor Stroma, Tumor Blood Vessels, and Antiangiogenesis Therapy.
Visintin A, Knowlton K, Tyminski E, Lin CI, Zheng X, Marquette K, Jain S, Tchistiakova L, Li D, O'Donnell CJ, Maderna A, Cao X, Dunn R, Snyder WB, Abraham AK, Leal M, Shetty S, Barry A, Zawel L, Coyle AJ, Dvorak HF, Jaminet SC
Novel Anti-TM4SF1 Antibody-Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature. Mol Cancer Ther. 2015 Aug; 14(8):1868-76.
Novel Anti-TM4SF1 Antibody-Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature.
Sciuto TE, Merley A, Lin CI, Richardson D, Liu Y, Li D, Dvorak AM, Dvorak HF, Jaminet SC
Intracellular distribution of TM4SF1 and internalization of TM4SF1-antibody complex in vascular endothelial cells. Biochem Biophys Res Commun. 2015 Sep 25; 465(3):338-43.
Intracellular distribution of TM4SF1 and internalization of TM4SF1-antibody complex in vascular endothelial cells.
Connor Y, Tekleab S, Nandakumar S, Walls C, Tekleab Y, Husain A, Gadish O, Sabbisetti V, Kaushik S, Sehrawat S, Kulkarni A, Dvorak H, Zetter B, R Edelman E, Sengupta S
Physical nanoscale conduit-mediated communication between tumour cells and the endothelium modulates endothelial phenotype. Nat Commun. 2015 Dec 16; 6:8671.
Physical nanoscale conduit-mediated communication between tumour cells and the endothelium modulates endothelial phenotype.
Uhlik MT, Liu J, Falcon BL, Iyer S, Stewart J, Celikkaya H, O'Mahony M, Sevinsky C, Lowes C, Douglass L, Jeffries C, Bodenmiller D, Chintharlapalli S, Fischl A, Gerald D, Xue Q, Lee JY, Santamaria-Pang A, Al-Kofahi Y, Sui Y, Desai K, Doman T, Aggarwal A, Carter JH, Pytowski B, Jaminet SC, Ginty F, Nasir A, Nagy JA, Dvorak HF, Benjamin LE
Stromal-Based Signatures for the Classification of Gastric Cancer. Cancer Res. 2016 05 01; 76(9):2573-86.
Stromal-Based Signatures for the Classification of Gastric Cancer.
Adenoviral vectors for delivery of angiogenic cytokines
PATHOGENESIS OF TUMOR STROMA GENERATION &WOUND HEALING
PERMSELECTIVE PROPERTIES OF TUMOR AND WOUND BLOOD VESSEL
Training Program in Angiogenesis and Inflammation
Spatial and Temporal Regulation of Angiogenesis
GORDON RESEARCH--ANGIOGENESIS AND MICROCIRCULATION
Bridgeman VL, Vermeulen PB, Foo S, Bilecz A, Daley F, Kostaras E, Nathan MR, Wan E, Frentzas S, Schweiger T, Hegedus B, Hoetzenecker K, Renyi-Vamos F, Kuczynski EA, Vasudev NS, Larkin J, Gore M, Dvorak HF, Paku S, Kerbel RS, Dome B, Reynolds AR
Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models. J Pathol. 2017 Feb; 241(3):362-374.
Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models.
Pathways of macromolecular tracer transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood vessels. Lab Invest. 1992 Nov; 67(5):596-607.
Pathways of macromolecular tracer transport across venules and small veins. Structural basis for the hyperpermeability of tumor blood vessels.
Carlson I, Tognazzi K, Manseau EJ, Dvorak HF, Brown LF
Osteopontin is strongly expressed by histiocytes in granulomas of diverse etiology. Lab Invest. 1997 Jul; 77(1):103-8.
Osteopontin is strongly expressed by histiocytes in granulomas of diverse etiology.
Brown LF, Berse B, Tognazzi K, Manseau EJ, Van de Water L, Senger DR, Dvorak HF, Rosen S
Vascular permeability factor mRNA and protein expression in human kidney. Kidney Int. 1992 Dec; 42(6):1457-61.
Vascular permeability factor mRNA and protein expression in human kidney.
Sundberg C, Kowanetz M, Brown LF, Detmar M, Dvorak HF
Stable expression of angiopoietin-1 and other markers by cultured pericytes: phenotypic similarities to a subpopulation of cells in maturing vessels during later stages of angiogenesis in vivo. Lab Invest. 2002 Apr; 82(4):387-401.
Stable expression of angiopoietin-1 and other markers by cultured pericytes: phenotypic similarities to a subpopulation of cells in maturing vessels during later stages of angiogenesis in vivo.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
EFFECT OF MACROPHAGES ON PRIMARY IMMUNIZATION OF LYMPH NODE CELLS AGAINST HOMOGRAFTS IN DIFFUSION CHAMBERS. Proc Soc Exp Biol Med. 1964 Oct; 117:110-5.
EFFECT OF MACROPHAGES ON PRIMARY IMMUNIZATION OF LYMPH NODE CELLS AGAINST HOMOGRAFTS IN DIFFUSION CHAMBERS.
Weller PF, Monahan-Earley RA, Dvorak HF, Dvorak AM
Cytoplasmic lipid bodies of human eosinophils. Subcellular isolation and analysis of arachidonate incorporation. Am J Pathol. 1991 Jan; 138(1):141-8.
Cytoplasmic lipid bodies of human eosinophils. Subcellular isolation and analysis of arachidonate incorporation.
Dvorak HF, Sioussat TM, Brown LF, Berse B, Nagy JA, Sotrel A, Manseau EJ, Van de Water L, Senger DR
Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels. J Exp Med. 1991 Nov 01; 174(5):1275-8.
Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels.
Tumor-secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells. Am J Pathol. 1991 Jan; 138(1):213-21.
Tumor-secreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells.
Vascular permeability factor/vascular endothelial growth factor inhibits anchorage-disruption-induced apoptosis in microvessel endothelial cells by inducing scaffold formation. Exp Cell Res. 1997 Jun 15; 233(2):340-9.
Vascular permeability factor/vascular endothelial growth factor inhibits anchorage-disruption-induced apoptosis in microvessel endothelial cells by inducing scaffold formation.
Pettersson A, Nagy JA, Brown LF, Sundberg C, Morgan E, Jungles S, Carter R, Krieger JE, Manseau EJ, Harvey VS, Eckelhoefer IA, Feng D, Dvorak AM, Mulligan RC, Dvorak HF
Heterogeneity of the angiogenic response induced in different normal adult tissues by vascular permeability factor/vascular endothelial growth factor. Lab Invest. 2000 Jan; 80(1):99-115.
Heterogeneity of the angiogenic response induced in different normal adult tissues by vascular permeability factor/vascular endothelial growth factor.
Platelets exit venules by a transcellular pathway at sites of F-met peptide-induced acute inflammation in guinea pigs. Int Arch Allergy Immunol. 1998 Jul; 116(3):188-95.
Platelets exit venules by a transcellular pathway at sites of F-met peptide-induced acute inflammation in guinea pigs.
Nagy JA, Chang SH, Shih SC, Dvorak AM, Dvorak HF
Heterogeneity of the tumor vasculature. Semin Thromb Hemost. 2010 Apr; 36(3):321-31.
Detmar M, Brown LF, Berse B, Jackman RW, Elicker BM, Dvorak HF, Claffey KP
Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptors in human skin. J Invest Dermatol. 1997 Mar; 108(3):263-8.
Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptors in human skin.
Fu Y, Comella N, Tognazzi K, Brown LF, Dvorak HF, Kocher O
Cloning of DLM-1, a novel gene that is up-regulated in activated macrophages, using RNA differential display. Gene. 1999 Nov 15; 240(1):157-63.
Cloning of DLM-1, a novel gene that is up-regulated in activated macrophages, using RNA differential display.
Orenstein NS, Dvorak HF, Blanchard MH, Young M
Nerve growth factor: a protease that can activate plasminogen. Proc Natl Acad Sci U S A. 1978 Nov; 75(11):5497-500.
Nerve growth factor: a protease that can activate plasminogen.
Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) peceptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways. J Biol Chem. 2001 Jul 20; 276(29):26969-79.
Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) peceptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways.
Effect of ribonuclease upon immunologically active cells. Proc Soc Exp Biol Med. 1961 Dec; 108:564-6.
Effect of ribonuclease upon immunologically active cells.
Brown LF, Detmar M, Claffey K, Nagy JA, Feng D, Dvorak AM, Dvorak HF
Vascular permeability factor/vascular endothelial growth factor: a multifunctional angiogenic cytokine. EXS. 1997; 79:233-69.
Vascular permeability factor/vascular endothelial growth factor: a multifunctional angiogenic cytokine.
Ultrastructural studies define soluble macromolecular, particulate, and cellular transendothelial cell pathways in venules, lymphatic vessels, and tumor-associated microvessels in man and animals. Microsc Res Tech. 2002 Jun 01; 57(5):289-326.
Ultrastructural studies define soluble macromolecular, particulate, and cellular transendothelial cell pathways in venules, lymphatic vessels, and tumor-associated microvessels in man and animals.
Shockley TR, Lin K, Nagy JA, Tompkins RG, Yarmush ML, Dvorak HF
Spatial distribution of tumor-specific monoclonal antibodies in human melanoma xenografts. Cancer Res. 1992 Jan 15; 52(2):367-76.
Spatial distribution of tumor-specific monoclonal antibodies in human melanoma xenografts.
Basu S, Nagy JA, Pal S, Vasile E, Eckelhoefer IA, Bliss VS, Manseau EJ, Dasgupta PS, Dvorak HF, Mukhopadhyay D
The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor. Nat Med. 2001 May; 7(5):569-74.
The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor.
Mukhopadhyay D, Nagy JA, Manseau EJ, Dvorak HF
Vascular permeability factor/vascular endothelial growth factor-mediated signaling in mouse mesentery vascular endothelium. Cancer Res. 1998 Mar 15; 58(6):1278-84.
Vascular permeability factor/vascular endothelial growth factor-mediated signaling in mouse mesentery vascular endothelium.
Neulen J, Raczek S, Pogorzelski M, Grunwald K, Yeo TK, Dvorak HF, Weich HA, Breckwoldt M
Secretion of vascular endothelial growth factor/vascular permeability factor from human luteinized granulosa cells is human chorionic gonadotrophin dependent. Mol Hum Reprod. 1998 Mar; 4(3):203-6.
Secretion of vascular endothelial growth factor/vascular permeability factor from human luteinized granulosa cells is human chorionic gonadotrophin dependent.
Cancer cells (Cold Spring Harbor, N.Y. : 1989)
Structure of solid tumors and their vasculature: implications for therapy with monoclonal antibodies. Cancer Cells. 1991 Mar; 3(3):77-85.
Structure of solid tumors and their vasculature: implications for therapy with monoclonal antibodies.
Pal S, Claffey KP, Dvorak HF, Mukhopadhyay D
The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways. J Biol Chem. 1997 Oct 31; 272(44):27509-12.
The von Hippel-Lindau gene product inhibits vascular permeability factor/vascular endothelial growth factor expression in renal cell carcinoma by blocking protein kinase C pathways.
Berse B, Brown LF, Van de Water L, Dvorak HF, Senger DR
Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol Biol Cell. 1992 Feb; 3(2):211-20.
Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors.
Nagy JA, Feng D, Vasile E, Wong WH, Shih SC, Dvorak AM, Dvorak HF
Permeability properties of tumor surrogate blood vessels induced by VEGF-A. Lab Invest. 2006 Aug; 86(8):767-80.
Permeability properties of tumor surrogate blood vessels induced by VEGF-A.
Brown LF, Berse B, Van de Water L, Papadopoulos-Sergiou A, Perruzzi CA, Manseau EJ, Dvorak HF, Senger DR
Expression and distribution of osteopontin in human tissues: widespread association with luminal epithelial surfaces. Mol Biol Cell. 1992 Oct; 3(10):1169-80.
Expression and distribution of osteopontin in human tissues: widespread association with luminal epithelial surfaces.
Sundberg C, Nagy JA, Brown LF, Feng D, Eckelhoefer IA, Manseau EJ, Dvorak AM, Dvorak HF
Glomeruloid microvascular proliferation follows adenoviral vascular permeability factor/vascular endothelial growth factor-164 gene delivery. Am J Pathol. 2001 Mar; 158(3):1145-60.
Glomeruloid microvascular proliferation follows adenoviral vascular permeability factor/vascular endothelial growth factor-164 gene delivery.
Watanabe Y, Lee SW, Detmar M, Ajioka I, Dvorak HF
Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells. Oncogene. 1997 May 01; 14(17):2025-32.
Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells.
Nagy JA, Benjamin L, Zeng H, Dvorak AM, Dvorak HF
Vascular permeability, vascular hyperpermeability and angiogenesis. Angiogenesis. 2008; 11(2):109-19.
Vascular permeability, vascular hyperpermeability and angiogenesis.
Luttun A, Tjwa M, Moons L, Wu Y, Angelillo-Scherrer A, Liao F, Nagy JA, Hooper A, Priller J, De Klerck B, Compernolle V, Daci E, Bohlen P, Dewerchin M, Herbert JM, Fava R, Matthys P, Carmeliet G, Collen D, Dvorak HF, Hicklin DJ, Carmeliet P
Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med. 2002 Aug; 8(8):831-40.
Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1.
Feng D, Nagy JA, Brekken RA, Pettersson A, Manseau EJ, Pyne K, Mulligan R, Thorpe PE, Dvorak HF, Dvorak AM
Ultrastructural localization of the vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) receptor-2 (FLK-1, KDR) in normal mouse kidney and in the hyperpermeable vessels induced by VPF/VEGF-expressing tumors and adenoviral vectors. J Histochem Cytochem. 2000 Apr; 48(4):545-56.
Ultrastructural localization of the vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) receptor-2 (FLK-1, KDR) in normal mouse kidney and in the hyperpermeable vessels induced by VPF/VEGF-expressing tumors and adenoviral vectors.
Rous-Whipple Award Lecture. How tumors make bad blood vessels and stroma. Am J Pathol. 2003 Jun; 162(6):1747-57.
Rous-Whipple Award Lecture. How tumors make bad blood vessels and stroma.
Fu Y, Nagy JA, Brown LF, Shih SC, Johnson PY, Chan CK, Dvorak HF, Wight TN
Proteolytic cleavage of versican and involvement of ADAMTS-1 in VEGF-A/VPF-induced pathological angiogenesis. J Histochem Cytochem. 2011 May; 59(5):463-73.
Proteolytic cleavage of versican and involvement of ADAMTS-1 in VEGF-A/VPF-induced pathological angiogenesis.
Roblin RO, Hammond ME, Bensky ND, Dvorak AM, Dvorak HF, Black PH
Generation of macrophage migration inhibitory activity by plasminogen activators. Proc Natl Acad Sci U S A. 1977 Apr; 74(4):1570-4.
Generation of macrophage migration inhibitory activity by plasminogen activators.
Senger DR, Connolly DT, Van de Water L, Feder J, Dvorak HF
Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor. Cancer Res. 1990 Mar 15; 50(6):1774-8.
Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor.
Carman CV, Sage PT, Sciuto TE, de la Fuente MA, Geha RS, Ochs HD, Dvorak HF, Dvorak AM, Springer TA
Transcellular diapedesis is initiated by invasive podosomes. Immunity. 2007 Jun; 26(6):784-97.
Transcellular diapedesis is initiated by invasive podosomes.
Yeo TK, Senger DR, Dvorak HF, Freter L, Yeo KT
Glycosylation is essential for efficient secretion but not for permeability-enhancing activity of vascular permeability factor (vascular endothelial growth factor). Biochem Biophys Res Commun. 1991 Sep 30; 179(3):1568-75.
Glycosylation is essential for efficient secretion but not for permeability-enhancing activity of vascular permeability factor (vascular endothelial growth factor).
Fossel ET, Dvorak HF, Carr JM, McDonagh J
European journal of cancer (Oxford, England : 1990)
Alteration of aliphatic lipid proton NMR linewidths by malignant tumors in guinea pigs. Eur J Cancer. 1990 Jan; 26(1):29-32.
Alteration of aliphatic lipid proton NMR linewidths by malignant tumors in guinea pigs.
Boesiger J, Tsai M, Maurer M, Yamaguchi M, Brown LF, Claffey KP, Dvorak HF, Galli SJ
Mast cells can secrete vascular permeability factor/ vascular endothelial cell growth factor and exhibit enhanced release after immunoglobulin E-dependent upregulation of fc epsilon receptor I expression. J Exp Med. 1998 Sep 21; 188(6):1135-45.
Mast cells can secrete vascular permeability factor/ vascular endothelial cell growth factor and exhibit enhanced release after immunoglobulin E-dependent upregulation of fc epsilon receptor I expression.
Caveolae and vesiculo-vacuolar organelles in bovine capillary endothelial cells cultured with VPF/VEGF on floating Matrigel-collagen gels. J Histochem Cytochem. 1999 Feb; 47(2):159-67.
Caveolae and vesiculo-vacuolar organelles in bovine capillary endothelial cells cultured with VPF/VEGF on floating Matrigel-collagen gels.
Epstein SE, Kornowski R, Fuchs S, Dvorak HF
Angiogenesis therapy: amidst the hype, the neglected potential for serious side effects. Circulation. 2001 Jul 03; 104(1):115-9.
Angiogenesis therapy: amidst the hype, the neglected potential for serious side effects.
Nagy JA, Brown LF, Senger DR, Lanir N, Van de Water L, Dvorak AM, Dvorak HF
Pathogenesis of tumor stroma generation: a critical role for leaky blood vessels and fibrin deposition. Biochim Biophys Acta. 1989 Feb; 948(3):305-26.
Pathogenesis of tumor stroma generation: a critical role for leaky blood vessels and fibrin deposition.
Chang SH, Kanasaki K, Gocheva V, Blum G, Harper J, Moses MA, Shih SC, Nagy JA, Joyce J, Bogyo M, Kalluri R, Dvorak HF
VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation. Cancer Res. 2009 May 15; 69(10):4537-44.
VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation.
Stiver SI, Tan X, Brown LF, Hedley-Whyte ET, Dvorak HF
Journal of neuropathology and experimental neurology
VEGF-A angiogenesis induces a stable neovasculature in adult murine brain. J Neuropathol Exp Neurol. 2004 Aug; 63(8):841-55.
VEGF-A angiogenesis induces a stable neovasculature in adult murine brain.
Dvorak HF, Orenstein NS, Galli SJ, Dvorak AM
Plasminogen activator of guinea pig basophils. A protease probably localized to the cell surface. Monogr Allergy. 1979; 14:249-52.
Plasminogen activator of guinea pig basophils. A protease probably localized to the cell surface.
Archives of pathology & laboratory medicine
The basophil. Its morphology, biochemistry, motility, release reactions, recovery, and role in the inflammatory responses of IgE-mediated and cell-mediated origin. Arch Pathol Lab Med. 1979 Oct; 103(11):551-7.
The basophil. Its morphology, biochemistry, motility, release reactions, recovery, and role in the inflammatory responses of IgE-mediated and cell-mediated origin.
Nature of the immunogen in crystalline serum albumins. Immunochemistry. 1970 Jan; 7(1):118-24.
Nature of the immunogen in crystalline serum albumins.
Discovery of vascular permeability factor (VPF). Exp Cell Res. 2006 Mar 10; 312(5):522-6.
Discovery of vascular permeability factor (VPF).
Hammel I, Dvorak AM, Peters SP, Schulman ES, Dvorak HF, Lichtenstein LM, Galli SJ
Differences in the volume distributions of human lung mast cell granules and lipid bodies: evidence that the size of these organelles is regulated by distinct mechanisms. J Cell Biol. 1985 May; 100(5):1488-92.
Differences in the volume distributions of human lung mast cell granules and lipid bodies: evidence that the size of these organelles is regulated by distinct mechanisms.
Immunologic unresponsiveness in the adult guinea pig. II. The kinetics of unresponsiveness. J Immunol. 1966 Mar; 96(3):546-53.
Immunologic unresponsiveness in the adult guinea pig. II. The kinetics of unresponsiveness.
Role of basophilic leukocytes in cellular immunity to vaccinia virus infection. J Immunol. 1971 Dec; 107(6):1576-82.
Role of basophilic leukocytes in cellular immunity to vaccinia virus infection.
Dvorak HF, Dvorak AM, Simpson BA, Richerson HB, Leskowitz S, Karnovsky MJ
Cutaneous basophil hypersensitivity. II. A light and electron microscopic description. J Exp Med. 1970 Sep 01; 132(3):558-82.
Cutaneous basophil hypersensitivity. II. A light and electron microscopic description.
Morphologic changes in draining lymph nodes and in lymphocyte cultures after sensitization with complete or incomplete Freund's adjuvant. Correlation with immunologic events in vivo and in culture. J Immunol. 1971 Aug; 107(2):422-35.
Morphologic changes in draining lymph nodes and in lymphocyte cultures after sensitization with complete or incomplete Freund's adjuvant. Correlation with immunologic events in vivo and in culture.
Dvorak AM, Newball HH, Dvorak HF, Lichtenstein LM
Antigen-induced IgE-mediated degranulation of human basophils. Lab Invest. 1980 Aug; 43(2):126-39.
Antigen-induced IgE-mediated degranulation of human basophils.
Dvorak HF, Dvorak AM, Manseau EJ, Wiberg L, Churchill WH
Fibrin gel investment associated with line 1 and line 10 solid tumor growth, angiogenesis, and fibroplasia in guinea pigs. Role of cellular immunity, myofibroblasts, microvascular damage, and infarction in line 1 tumor regression. J Natl Cancer Inst. 1979 Jun; 62(6):1459-72.
Fibrin gel investment associated with line 1 and line 10 solid tumor growth, angiogenesis, and fibroplasia in guinea pigs. Role of cellular immunity, myofibroblasts, microvascular damage, and infarction in line 1 tumor regression.
Ultrastructural criteria for identification of mast cells and basophils in humans, guinea pigs, and mice. Am Rev Respir Dis. 1983 Aug; 128(2 Pt 2):S49-52.
Ultrastructural criteria for identification of mast cells and basophils in humans, guinea pigs, and mice.
Dvorak AM, Hammel I, Schulman ES, Peters SP, MacGlashan DW, Schleimer RP, Newball HH, Pyne K, Dvorak HF, Lichtenstein LM
Differences in the behavior of cytoplasmic granules and lipid bodies during human lung mast cell degranulation. J Cell Biol. 1984 Nov; 99(5):1678-87.
Differences in the behavior of cytoplasmic granules and lipid bodies during human lung mast cell degranulation.
Dvorak AM, Hammond ME, Morgan ES, Dvorak HF
Ultrastructural studies of macrophages: in vitro removal of cell coat with macrophage inhibition factor (MIF)-containing lymphocyte culture supernatants; chloroform extraction, phospholipase digestion, and autoradiographic studies. J Reticuloendothel Soc. 1980 Feb; 27(2):119-42.
Ultrastructural studies of macrophages: in vitro removal of cell coat with macrophage inhibition factor (MIF)-containing lymphocyte culture supernatants; chloroform extraction, phospholipase digestion, and autoradiographic studies.
Nagy JA, Morgan ES, Herzberg KT, Manseau EJ, Dvorak AM, Dvorak HF
Pathogenesis of ascites tumor growth: angiogenesis, vascular remodeling, and stroma formation in the peritoneal lining. Cancer Res. 1995 Jan 15; 55(2):376-85.
Pathogenesis of ascites tumor growth: angiogenesis, vascular remodeling, and stroma formation in the peritoneal lining.
Nagy JA, Masse EM, Herzberg KT, Meyers MS, Yeo KT, Yeo TK, Sioussat TM, Dvorak HF
Pathogenesis of ascites tumor growth: vascular permeability factor, vascular hyperpermeability, and ascites fluid accumulation. Cancer Res. 1995 Jan 15; 55(2):360-8.
Pathogenesis of ascites tumor growth: vascular permeability factor, vascular hyperpermeability, and ascites fluid accumulation.
Brown LF, Papadopoulos-Sergiou A, Berse B, Manseau EJ, Tognazzi K, Perruzzi CA, Dvorak HF, Senger DR
Osteopontin expression and distribution in human carcinomas. Am J Pathol. 1994 Sep; 145(3):610-23.
Osteopontin expression and distribution in human carcinomas.
Feng D, Nagy JA, Hipp J, Dvorak HF, Dvorak AM
Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin. J Exp Med. 1996 May 01; 183(5):1981-6.
Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin.
Qin L, Zhao D, Liu X, Nagy JA, Hoang MV, Brown LF, Dvorak HF, Zeng H
Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway. Mol Cancer Res. 2006 Nov; 4(11):811-20.
Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway.
Brown LF, Guidi AJ, Tognazzi K, Dvorak HF
Vascular permeability factor/vascular endothelial growth factor and vascular stroma formation in neoplasia. Insights from in situ hybridization studies. J Histochem Cytochem. 1998 May; 46(5):569-75.
Vascular permeability factor/vascular endothelial growth factor and vascular stroma formation in neoplasia. Insights from in situ hybridization studies.
Brown LF, Yeo KT, Berse B, Yeo TK, Senger DR, Dvorak HF, van de Water L
Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med. 1992 Nov 01; 176(5):1375-9.
Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing.
Progress in clinical and biological research
Leaky tumor vessels: consequences for tumor stroma generation and for solid tumor therapy. Prog Clin Biol Res. 1990; 354A:317-30.
Leaky tumor vessels: consequences for tumor stroma generation and for solid tumor therapy.
Nagy JA, Shih SC, Wong WH, Dvorak AM, Dvorak HF
Chapter 3. The adenoviral vector angiogenesis/lymphangiogenesis assay. Methods Enzymol. 2008; 444:43-64.
Chapter 3. The adenoviral vector angiogenesis/lymphangiogenesis assay.
Dvorak HF, Harvey VS, Estrella P, Brown LF, McDonagh J, Dvorak AM
Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing. Lab Invest. 1987 Dec; 57(6):673-86.
Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing.
Feder J, Kimes RC, Tolbert WR, Cleveland C, Hammond ME, Orenstein NS, Goodwin J, Dvorak HF
Plasminogen activator and MIF-like activities in Kirsten virus transformed mouse NIH culture fluids. Biochem Biophys Res Commun. 1978 Aug 14; 83(3):1164-70.
Plasminogen activator and MIF-like activities in Kirsten virus transformed mouse NIH culture fluids.
deShazo RD, Levinson AI, Dvorak HF, Davis RW
The late phase skin reaction: evidence for activation of the coagulation system in an IgE-dependent reaction in man. J Immunol. 1979 Feb; 122(2):692-8.
The late phase skin reaction: evidence for activation of the coagulation system in an IgE-dependent reaction in man.
Sitohy B, Chang S, Sciuto TE, Masse E, Shen M, Kang PM, Jaminet SC, Benjamin LE, Bhatt RS, Dvorak AM, Nagy JA, Dvorak HF
Early Actions of Anti-Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor Drugs on Angiogenic Blood Vessels. Am J Pathol. 2017 Oct; 187(10):2337-2347.
Early Actions of Anti-Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor Drugs on Angiogenic Blood Vessels.
Dvorak HF, Senger DR, Dvorak AM, Harvey VS, McDonagh J
Regulation of extravascular coagulation by microvascular permeability. Science. 1985 Mar 01; 227(4690):1059-61.
Regulation of extravascular coagulation by microvascular permeability.
VanDeWater L, Tracy PB, Aronson D, Mann KG, Dvorak HF
Tumor cell generation of thrombin via functional prothrombinase assembly. Cancer Res. 1985 Nov; 45(11 Pt 1):5521-5.
Tumor cell generation of thrombin via functional prothrombinase assembly.
Purification and properties of two acid phosphatase fractions isolated from osmotic shock fluid of Escherichia coli. Biochemistry. 1967 Jun; 6(6):1743-51.
Purification and properties of two acid phosphatase fractions isolated from osmotic shock fluid of Escherichia coli.
Dvorak HF, Mihm MC, Dvorak AM, Johnson RA, Manseau EJ, Morgan E, Colvin RB
Morphology of delayed type hypersensitivity reactions in man. I. Quantitative description of the inflammatory response. Lab Invest. 1974 Aug; 31(2):111-30.
Morphology of delayed type hypersensitivity reactions in man. I. Quantitative description of the inflammatory response.
Dvorak AM, Roblin RO, Morgan ES, Dvorak HF
Ultrastructure of the cell coat of untransformed and simian virus 40-transformed fibroblasts. J Reticuloendothel Soc. 1979 Feb; 25(2):163-77.
Ultrastructure of the cell coat of untransformed and simian virus 40-transformed fibroblasts.
American journal of respiratory and critical care medicine
The negative tuberculin test: tuberculin, HIV, and anergy panels. Am J Respir Crit Care Med. 1995 Feb; 151(2 Pt 1):580.
The negative tuberculin test: tuberculin, HIV, and anergy panels.
Fibrinogen/fibrin on the surface of macrophages: detection, distribution, binding requirements, and possible role in macrophage adherence phenomena. J Exp Med. 1975 Dec 01; 142(6):1377-90.
Fibrinogen/fibrin on the surface of macrophages: detection, distribution, binding requirements, and possible role in macrophage adherence phenomena.
Different pathways of macromolecule extravasation from hyperpermeable tumor vessels. Microvasc Res. 2000 Jan; 59(1):24-37.
Different pathways of macromolecule extravasation from hyperpermeable tumor vessels.
Shockley TR, Lin K, Sung C, Nagy JA, Tompkins RG, Dedrick RL, Dvorak HF, Yarmush ML
A quantitative analysis of tumor specific monoclonal antibody uptake by human melanoma xenografts: effects of antibody immunological properties and tumor antigen expression levels. Cancer Res. 1992 Jan 15; 52(2):357-66.
A quantitative analysis of tumor specific monoclonal antibody uptake by human melanoma xenografts: effects of antibody immunological properties and tumor antigen expression levels.
Journal of thrombosis and haemostasis : JTH
Angiogenesis: update 2005. J Thromb Haemost. 2005 Aug; 3(8):1835-42.
Guidi AJ, Schnitt SJ, Fischer L, Tognazzi K, Harris JR, Dvorak HF, Brown LF
Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in patients with ductal carcinoma in situ of the breast. Cancer. 1997 Nov 15; 80(10):1945-53.
Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in patients with ductal carcinoma in situ of the breast.
Monahan-Earley RA, Isomura T, Garcia RI, Galli SJ, Dvorak HF, Dvorak AM
Nonspecific esterase activity expressed in Weibel-Palade bodies of cloned guinea pig aortic endothelial cells. J Histochem Cytochem. 1987 May; 35(5):531-9.
Nonspecific esterase activity expressed in Weibel-Palade bodies of cloned guinea pig aortic endothelial cells.
Structure of Freund's complete and incomplete adjuvants. Relation of adjuvanticity to structure. Immunology. 1974 Jul; 27(1):99-114.
Structure of Freund's complete and incomplete adjuvants. Relation of adjuvanticity to structure.
Fibronectin beneath reepithelializing epidermis in vivo: sources and significance. J Invest Dermatol. 1983 Jun; 80 Suppl:26s-30s.
Tissue factor activity of normal and neoplastic cells: quantitation and species specificity. J Natl Cancer Inst. 1983 Mar; 70(3):551-7.
Tissue factor activity of normal and neoplastic cells: quantitation and species specificity.
International review of experimental pathology
Expression of cell-mediated hypersensitivity in vivo--recent advances. Int Rev Exp Pathol. 1980; 21:119-94.
Expression of cell-mediated hypersensitivity in vivo--recent advances.
Morphology of delayed-type hypersensitivity reactions in the guinea pig cornea. J Immunol. 1977 May; 118(5):1558-63.
Morphology of delayed-type hypersensitivity reactions in the guinea pig cornea.
Claffey KP, Brown LF, del Aguila LF, Tognazzi K, Yeo KT, Manseau EJ, Dvorak HF
Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis. Cancer Res. 1996 Jan 01; 56(1):172-81.
Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis.
Schacht V, Ramirez MI, Hong YK, Hirakawa S, Feng D, Harvey N, Williams M, Dvorak AM, Dvorak HF, Oliver G, Detmar M
T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J. 2003 Jul 15; 22(14):3546-56.
T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema.
Primary immunization of lymph node cells in millipore chambers by exposure to homograft antigen. J Exp Med. 1962 Jul 01; 116:1-16.
Primary immunization of lymph node cells in millipore chambers by exposure to homograft antigen.
Zukauskas A, Merley A, Li D, Ang LH, Sciuto TE, Salman S, Dvorak AM, Dvorak HF, Jaminet SC
TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration. Angiogenesis. 2011 Sep; 14(3):345-54.
TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration.
Qin L, Zhao D, Xu J, Ren X, Terwilliger EF, Parangi S, Lawler J, Dvorak HF, Zeng H
The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1. Blood. 2013 Mar 14; 121(11):2154-64.
The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1.
Dvorak HF, Nagy JA, Berse B, Brown LF, Yeo KT, Yeo TK, Dvorak AM, van de Water L, Sioussat TM, Senger DR
Vascular permeability factor, fibrin, and the pathogenesis of tumor stroma formation. Ann N Y Acad Sci. 1992 Dec 04; 667:101-11.
Vascular permeability factor, fibrin, and the pathogenesis of tumor stroma formation.
Ultrastructural immunogold localization of osteopontin in human gastric mucosa. J Histochem Cytochem. 1997 Jan; 45(1):21-33.
Ultrastructural immunogold localization of osteopontin in human gastric mucosa.
Nagy JA, Eckelhoefer IA, Masse EM, Dvorak AM, Dvorak HF
Vascular targeting of solid and ascites tumours with antibodies to vascular endothelial growth factor. Eur J Cancer. 1996 Dec; 32A(14):2467-73.
Vascular targeting of solid and ascites tumours with antibodies to vascular endothelial growth factor.
Zeng H, Qin L, Zhao D, Tan X, Manseau EJ, Van Hoang M, Senger DR, Brown LF, Nagy JA, Dvorak HF
Orphan nuclear receptor TR3/Nur77 regulates VEGF-A-induced angiogenesis through its transcriptional activity. J Exp Med. 2006 Mar 20; 203(3):719-29.
Orphan nuclear receptor TR3/Nur77 regulates VEGF-A-induced angiogenesis through its transcriptional activity.
Dorey CK, Aouididi S, Reynaud X, Dvorak HF, Brown LF
Archives of ophthalmology (Chicago, Ill. : 1960)
Correlation of vascular permeability factor/vascular endothelial growth factor with extraretinal neovascularization in the rat. Arch Ophthalmol. 1996 Oct; 114(10):1210-7.
Correlation of vascular permeability factor/vascular endothelial growth factor with extraretinal neovascularization in the rat.
Metallo-enzymes released from Escherichia coli by osmotic shock. I. Selective depression of enzymes in cells grown in the presence of ethylenediaminetetraacetate. J Biol Chem. 1968 May 25; 243(10):2640-6.
Metallo-enzymes released from Escherichia coli by osmotic shock. I. Selective depression of enzymes in cells grown in the presence of ethylenediaminetetraacetate.
Disseminated intravascular coagulation. N Engl J Med. 1969 Aug 07; 281(6):329.
Quantitation of fibrinogen influx and fibrin deposition and turnover in line 1 and line 10 guinea pig carcinomas. Cancer Res. 1984 Aug; 44(8):3348-54.
Quantitation of fibrinogen influx and fibrin deposition and turnover in line 1 and line 10 guinea pig carcinomas.
Cutaneous basophil hypersensitivity. J Allergy Clin Immunol. 1976 Jul; 58(1 PT. 2):229-40.
Harris NL, Dvorak AM, Smith J, Dvorak HF
Fibrin deposits in Hodgkin's disease. Am J Pathol. 1982 Jul; 108(1):119-29.
Dvorak AM, Nabel G, Pyne K, Cantor H, Dvorak HF, Galli SJ
Ultrastructural identification of the mouse basophil. Blood. 1982 Jun; 59(6):1279-85.
Ultrastructural identification of the mouse basophil.
Role of the clotting system in cell-mediated hypersensitivity. II. Kinetics of fibrinogen/fibrin accumulation and vascular permeability changes in tuberculin and cutaneous basophil hypersensitivity reactions. J Immunol. 1975 Jan; 114(1 Pt 2):377-87.
Role of the clotting system in cell-mediated hypersensitivity. II. Kinetics of fibrinogen/fibrin accumulation and vascular permeability changes in tuberculin and cutaneous basophil hypersensitivity reactions.
Nagy JA, Vasile E, Feng D, Sundberg C, Brown LF, Detmar MJ, Lawitts JA, Benjamin L, Tan X, Manseau EJ, Dvorak AM, Dvorak HF
Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis. J Exp Med. 2002 Dec 02; 196(11):1497-506.
Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis.
Nagy JA, Herzberg KT, Dvorak JM, Dvorak HF
Pathogenesis of malignant ascites formation: initiating events that lead to fluid accumulation. Cancer Res. 1993 Jun 01; 53(11):2631-43.
Pathogenesis of malignant ascites formation: initiating events that lead to fluid accumulation.
Wirzenius M, Tammela T, Uutela M, He Y, Odorisio T, Zambruno G, Nagy JA, Dvorak HF, Ylä-Herttuala S, Shibuya M, Alitalo K
Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting. J Exp Med. 2007 Jun 11; 204(6):1431-40.
Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting.
Brown LF, Van de Water L, Harvey VS, Dvorak HF
Fibrinogen influx and accumulation of cross-linked fibrin in healing wounds and in tumor stroma. Am J Pathol. 1988 Mar; 130(3):455-65.
Fibrinogen influx and accumulation of cross-linked fibrin in healing wounds and in tumor stroma.
Lanir N, Ciano PS, Van de Water L, McDonagh J, Dvorak AM, Dvorak HF
Macrophage migration in fibrin gel matrices. II. Effects of clotting factor XIII, fibronectin, and glycosaminoglycan content on cell migration. J Immunol. 1988 Apr 01; 140(7):2340-9.
Macrophage migration in fibrin gel matrices. II. Effects of clotting factor XIII, fibronectin, and glycosaminoglycan content on cell migration.
Brown LF, Chester JF, Malt RA, Dvorak HF
Fibrin deposition in autochthonous Syrian hamster pancreatic adenocarcinomas induced by the chemical carcinogen N-nitroso-bis(2-oxopropyl)amine. J Natl Cancer Inst. 1987 May; 78(5):979-86.
Fibrin deposition in autochthonous Syrian hamster pancreatic adenocarcinomas induced by the chemical carcinogen N-nitroso-bis(2-oxopropyl)amine.
Ciano PS, Colvin RB, Dvorak AM, McDonagh J, Dvorak HF
Macrophage migration in fibrin gel matrices. Lab Invest. 1986 Jan; 54(1):62-70.
Macrophage migration in fibrin gel matrices.
Metallo-enzymes released from Escherichia coli by osmotic shock. II. Evidence that 5'-nucleotidase and cyclic phosphodiesterase are zinc metallo-enzymes. J Biol Chem. 1968 May 25; 243(10):2647-53.
Metallo-enzymes released from Escherichia coli by osmotic shock. II. Evidence that 5'-nucleotidase and cyclic phosphodiesterase are zinc metallo-enzymes.
Hammond ME, Roblin RO, Dvorak AM, Selvaggio SS, Black PH, Dvorak HF
MIF-like activity in simian virus 40-transformed 3T3 fibroblast cultures. Science. 1974 Sep 13; 185(4155):955-7.
MIF-like activity in simian virus 40-transformed 3T3 fibroblast cultures.
Role of the basophilic leukocyte in allograft rejection. J Immunol. 1971 Jan; 106(1):279-81.
Role of the basophilic leukocyte in allograft rejection.
Orenstein NS, Galli SJ, Dvorak AM, Silbert JE, Dvorak HF
Sulfated glycosaminoglycans of guinea pig basophilic leukocytes. J Immunol. 1978 Aug; 121(2):586-92.
Sulfated glycosaminoglycans of guinea pig basophilic leukocytes.
The late phase skin reaction: paradigm or epiphenomena? Ann Allergy. 1983 Aug; 51(2 Pt 1):166-72.
The late phase skin reaction: paradigm or epiphenomena?
Dvorak HF, Form DM, Manseau EJ, Smith BD
Pathogenesis of desmoplasia. I. Immunofluorescence identification and localization of some structural proteins of line 1 and line 10 guinea pig tumors and of healing wounds. J Natl Cancer Inst. 1984 Nov; 73(5):1195-205.
Pathogenesis of desmoplasia. I. Immunofluorescence identification and localization of some structural proteins of line 1 and line 10 guinea pig tumors and of healing wounds.
Dvorak AM, Osage JE, Dvorak HF, Galli SJ
Surface membrane alterations in guinea pig basophils undergoing anaphylactic degranulation. A scanning electron microscopic study. Lab Invest. 1981 Jul; 45(1):58-66.
Surface membrane alterations in guinea pig basophils undergoing anaphylactic degranulation. A scanning electron microscopic study.
Orenstein NS, Hammond ME, Dvorak HF, Feder J
Esterase and protease activity of purified guinea pig basophil granules. Biochem Biophys Res Commun. 1976 Sep 07; 72(1):230-5.
Esterase and protease activity of purified guinea pig basophil granules.
Isomura T, Dvorak AM, Garcia RI, Dvorak HF, Galli SJ
Inbred guinea pig aortic endothelial cell clones. Model for studying the vascular endothelium under totally isologous conditions. Lab Invest. 1986 Dec; 55(6):703-16.
Inbred guinea pig aortic endothelial cell clones. Model for studying the vascular endothelium under totally isologous conditions.
Dvorak HF, Nagy JA, Dvorak JT, Dvorak AM
Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules. Am J Pathol. 1988 Oct; 133(1):95-109.
Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules.
Shih SC, Zukauskas A, Li D, Liu G, Ang LH, Nagy JA, Brown LF, Dvorak HF
The L6 protein TM4SF1 is critical for endothelial cell function and tumor angiogenesis. Cancer Res. 2009 Apr 15; 69(8):3272-7.
The L6 protein TM4SF1 is critical for endothelial cell function and tumor angiogenesis.
Xue Q, Nagy JA, Manseau EJ, Phung TL, Dvorak HF, Benjamin LE
Arteriosclerosis, thrombosis, and vascular biology
Rapamycin inhibition of the Akt/mTOR pathway blocks select stages of VEGF-A164-driven angiogenesis, in part by blocking S6Kinase. Arterioscler Thromb Vasc Biol. 2009 Aug; 29(8):1172-8.
Rapamycin inhibition of the Akt/mTOR pathway blocks select stages of VEGF-A164-driven angiogenesis, in part by blocking S6Kinase.
Zhang X, Kazerounian S, Duquette M, Perruzzi C, Nagy JA, Dvorak HF, Parangi S, Lawler J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level. FASEB J. 2009 Oct; 23(10):3368-76.
Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level.
Dvorak HF, Billote JB, McCarthy JS, Flax MH
Immunologic unresponsiveness in the adult guinea pig. 3. Variation of the antigen and vehicle of suppression. Induction of unresponsiveness in the adult rat. J Immunol. 1966 Jul; 97(1):106-11.
Immunologic unresponsiveness in the adult guinea pig. 3. Variation of the antigen and vehicle of suppression. Induction of unresponsiveness in the adult rat.
Dvorak HF, Selvaggio SS, Dvorak AM, Colvin RB, Lean DB, Rypysc J
Purification of basophilic leukocytes from guinea pig blood and bone marrow. J Immunol. 1974 Dec; 113(6):1694-702.
Purification of basophilic leukocytes from guinea pig blood and bone marrow.
Uptake of horseradish peroxidase by guinea pig basophilic leukocytes. Lab Invest. 1972 Jan; 26(1):27-39.
Uptake of horseradish peroxidase by guinea pig basophilic leukocytes.
Form DM, VanDeWater L, Dvorak HF, Smith BD
Pathogenesis of tumor desmoplasia. II. Collagens synthesized by line 1 and line 10 guinea pig carcinoma cells and by syngeneic fibroblasts in vitro. J Natl Cancer Inst. 1984 Nov; 73(5):1207-14.
Pathogenesis of tumor desmoplasia. II. Collagens synthesized by line 1 and line 10 guinea pig carcinoma cells and by syngeneic fibroblasts in vitro.
Dvorak HF, Dickersin GR, Dvorak AM, Manseau EJ, Pyne K
Human breast carcinoma: fibrin deposits and desmoplasia. Inflammatory cell type and distribution. Microvasculature and infarction. J Natl Cancer Inst. 1981 Aug; 67(2):335-45.
Human breast carcinoma: fibrin deposits and desmoplasia. Inflammatory cell type and distribution. Microvasculature and infarction.
Dvorak HF, Orenstein NS, Carvalho AC, Churchill WH, Dvorak AM, Galli SJ, Feder J, Bitzer AM, Rypysc J, Giovinco P
Induction of a fibrin-gel investment: an early event in line 10 hepatocarcinoma growth mediated by tumor-secreted products. J Immunol. 1979 Jan; 122(1):166-74.
Induction of a fibrin-gel investment: an early event in line 10 hepatocarcinoma growth mediated by tumor-secreted products.
Detmar M, Brown LF, Claffey KP, Yeo KT, Kocher O, Jackman RW, Berse B, Dvorak HF
Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J Exp Med. 1994 Sep 01; 180(3):1141-6.
Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis.
Brown LF, Senger DR, Geng LL, Dvorak HF, Dvorak AM
Ultrastructural immunogold localization of osteopontin in human gallbladder epithelial cells. J Histochem Cytochem. 1994 Mar; 42(3):351-61.
Ultrastructural immunogold localization of osteopontin in human gallbladder epithelial cells.
Brown LF, Berse B, Jackman RW, Tognazzi K, Manseau EJ, Senger DR, Dvorak HF
Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract. Cancer Res. 1993 Oct 01; 53(19):4727-35.
Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract.
Brown LF, Lanir N, McDonagh J, Tognazzi K, Dvorak AM, Dvorak HF
Fibroblast migration in fibrin gel matrices. Am J Pathol. 1993 Jan; 142(1):273-83.
Fibroblast migration in fibrin gel matrices.
Brown LF, Dubin D, Lavigne L, Logan B, Dvorak HF, Van de Water L
Macrophages and fibroblasts express embryonic fibronectins during cutaneous wound healing. Am J Pathol. 1993 Mar; 142(3):793-801.
Macrophages and fibroblasts express embryonic fibronectins during cutaneous wound healing.
Hoeppner LH, Phoenix KN, Clark KJ, Bhattacharya R, Gong X, Sciuto TE, Vohra P, Suresh S, Bhattacharya S, Dvorak AM, Ekker SC, Dvorak HF, Claffey KP, Mukhopadhyay D
Revealing the role of phospholipase Cß3 in the regulation of VEGF-induced vascular permeability. Blood. 2012 Sep 13; 120(11):2167-73.
Revealing the role of phospholipase Cß3 in the regulation of VEGF-induced vascular permeability.
Mast cells in the cortical tubular epithelium and interstitium in human renal disease. Hum Pathol. 1974 May; 5(3):315-26.
Mast cells in the cortical tubular epithelium and interstitium in human renal disease.
Dvorak HF, Orenstein NS, Rypysc J, Colvin RB, Dvorak AM
Plasminogen activator of guinea pig basophilic leukocytes: probable localization to the plasma membrane. J Immunol. 1978 Mar; 120(3):766-73.
Plasminogen activator of guinea pig basophilic leukocytes: probable localization to the plasma membrane.
Fibrin as a component of the tumor stroma: origins and biological significance. Cancer Metastasis Rev. 1983; 2(1):41-73.
Fibrin as a component of the tumor stroma: origins and biological significance.
Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science. 1983 Feb 25; 219(4587):983-5.
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Orenstein NS, Galli SJ, Dvorak AM, Dvorak HF
Glycosaminoglycans and proteases of guinea pig basophilic leukocytes. Kroc Found Ser. 1981; 14:123-43.
Glycosaminoglycans and proteases of guinea pig basophilic leukocytes.
Brown LF, Yeo KT, Berse B, Morgentaler A, Dvorak HF, Rosen S
Vascular permeability factor (vascular endothelial growth factor) is strongly expressed in the normal male genital tract and is present in substantial quantities in semen. J Urol. 1995 Aug; 154(2 Pt 1):576-9.
Vascular permeability factor (vascular endothelial growth factor) is strongly expressed in the normal male genital tract and is present in substantial quantities in semen.
Detmar M, Yeo KT, Nagy JA, Van de Water L, Brown LF, Berse B, Elicker BM, Ledbetter S, Dvorak HF
Keratinocyte-derived vascular permeability factor (vascular endothelial growth factor) is a potent mitogen for dermal microvascular endothelial cells. J Invest Dermatol. 1995 Jul; 105(1):44-50.
Keratinocyte-derived vascular permeability factor (vascular endothelial growth factor) is a potent mitogen for dermal microvascular endothelial cells.
Chang SH, Feng D, Nagy JA, Sciuto TE, Dvorak AM, Dvorak HF
Vascular permeability and pathological angiogenesis in caveolin-1-null mice. Am J Pathol. 2009 Oct; 175(4):1768-76.
Vascular permeability and pathological angiogenesis in caveolin-1-null mice.
Brown LF, Guidi AJ, Schnitt SJ, Van De Water L, Iruela-Arispe ML, Yeo TK, Tognazzi K, Dvorak HF
Clinical cancer research : an official journal of the American Association for Cancer Research
Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast. Clin Cancer Res. 1999 May; 5(5):1041-56.
Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast.
Mentzel T, Brown LF, Dvorak HF, Kuhnen C, Stiller KJ, Katenkamp D, Fletcher CD
Virchows Archiv : an international journal of pathology
The association between tumour progression and vascularity in myxofibrosarcoma and myxoid/round cell liposarcoma. Virchows Arch. 2001 Jan; 438(1):13-22.
The association between tumour progression and vascularity in myxofibrosarcoma and myxoid/round cell liposarcoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol. 2002 Nov 01; 20(21):4368-80.
Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy.
Phung TL, Ziv K, Dabydeen D, Eyiah-Mensah G, Riveros M, Perruzzi C, Sun J, Monahan-Earley RA, Shiojima I, Nagy JA, Lin MI, Walsh K, Dvorak AM, Briscoe DM, Neeman M, Sessa WC, Dvorak HF, Benjamin LE
Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. Cancer Cell. 2006 Aug; 10(2):159-70.
Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.
Neutrophils emigrate from venules by a transendothelial cell pathway in response to FMLP. J Exp Med. 1998 Mar 16; 187(6):903-15.
Neutrophils emigrate from venules by a transendothelial cell pathway in response to FMLP.
Galli SJ, Dvorak AM, Ishizaka T, Nabel G, Der Simonian H, Cantor H, Dvorak HF
A cloned cell with NK function resembles basophils by ultrastructure and expresses IgE receptors. Nature. 1982 Jul 15; 298(5871):288-90.
A cloned cell with NK function resembles basophils by ultrastructure and expresses IgE receptors.
Cryptic and active plasminogen activators secreted by line 10 tumor cells in culture. Cancer Res. 1983 Apr; 43(4):1783-9.
Cryptic and active plasminogen activators secreted by line 10 tumor cells in culture.
VPF/VEGF and the angiogenic response. Semin Perinatol. 2000 Feb; 24(1):75-8.
Brown LF, Dezube BJ, Tognazzi K, Dvorak HF, Yancopoulos GD
Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma. Am J Pathol. 2000 Jun; 156(6):2179-83.
Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma.
Vasile E, Tomita Y, Brown LF, Kocher O, Dvorak HF
Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis. FASEB J. 2001 Feb; 15(2):458-66.
Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis.
VEGF-A(164/165) and PlGF: roles in angiogenesis and arteriogenesis. Trends Cardiovasc Med. 2003 Jul; 13(5):169-75.
VEGF-A(164/165) and PlGF: roles in angiogenesis and arteriogenesis.
Senger DR, Brown LF, Claffey KP, Dvorak HF
Vascular permeability factor, tumor angiogenesis and stroma generation. Invasion Metastasis. 1994-1995; 14(1-6):385-94.
Vascular permeability factor, tumor angiogenesis and stroma generation.
Guidi AJ, Abu-Jawdeh G, Berse B, Jackman RW, Tognazzi K, Dvorak HF, Brown LF
Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia. J Natl Cancer Inst. 1995 Aug 16; 87(16):1237-45.
Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia.
Denhart BC, Guidi AJ, Tognazzi K, Dvorak HF, Brown LF
Vascular permeability factor/vascular endothelial growth factor and its receptors in oral and laryngeal squamous cell carcinoma and dysplasia. Lab Invest. 1997 Dec; 77(6):659-64.
Vascular permeability factor/vascular endothelial growth factor and its receptors in oral and laryngeal squamous cell carcinoma and dysplasia.