Professor of Medicine (Physiology), Emerita
Nitric oxide, myocardial oxygen consumption, and ATP synthesis. Circ Res. 1998 Nov 16; 83(10):1067-8.
Nitric oxide, myocardial oxygen consumption, and ATP synthesis.
Shen W, Tian R, Saupe KW, Spindler M, Ingwall JS
American journal of physiology. Heart and circulatory physiology
Endogenous nitric oxide enhances coupling between O2 consumption and ATP synthesis in guinea pig hearts. Am J Physiol Heart Circ Physiol. 2001 Aug; 281(2):H838-46.
Endogenous nitric oxide enhances coupling between O2 consumption and ATP synthesis in guinea pig hearts.
Luptak I, Sverdlov AL, Panagia M, Qin F, Pimentel DR, Croteau D, Siwik DA, Ingwall JS, Bachschmid MM, Balschi JA, Colucci WS
Journal of molecular and cellular cardiology
Decreased ATP production and myocardial contractile reserve in metabolic heart disease. J Mol Cell Cardiol. 2018 03; 116:106-114.
Decreased ATP production and myocardial contractile reserve in metabolic heart disease.
Saupe KW, Spindler M, Hopkins JC, Shen W, Ingwall JS
Kinetic, thermodynamic, and developmental consequences of deleting creatine kinase isoenzymes from the heart. Reaction kinetics of the creatine kinase isoenzymes in the intact heart. J Biol Chem. 2000 Jun 30; 275(26):19742-6.
Kinetic, thermodynamic, and developmental consequences of deleting creatine kinase isoenzymes from the heart. Reaction kinetics of the creatine kinase isoenzymes in the intact heart.
Contribution of Na+/H+ exchange to Na+ overload in the ischemic hypertrophied hyperthyroid rat heart. Cardiovasc Res. 2003 Mar 15; 57(4):1004-14.
Contribution of Na+/H+ exchange to Na+ overload in the ischemic hypertrophied hyperthyroid rat heart.
Regulation of heart creatine kinase. Basic Res Cardiol. 1987; 82 Suppl 2:93-101.
Goldhaber SZ, Newell JB, Alpert NM, Andrews E, Pohost GM, Ingwall JS
Effects of ischemic-like insult on myocardial thallium-201 accumulation. Circulation. 1983 Apr; 67(4):778-86.
Effects of ischemic-like insult on myocardial thallium-201 accumulation.
The fetal mouse heart in organ culture: maintenance of the differentiated state. Methods Cell Biol. 1980; 21A:167-86.
The fetal mouse heart in organ culture: maintenance of the differentiated state.
Kloner RA, DeBoer LW, Darsee JR, Ingwall JS, Braunwald E
Proceedings of the National Academy of Sciences of the United States of America
Recovery from prolonged abnormalities of canine myocardium salvaged from ischemic necrosis by coronary reperfusion. Proc Natl Acad Sci U S A. 1981 Nov; 78(11):7152-6.
Recovery from prolonged abnormalities of canine myocardium salvaged from ischemic necrosis by coronary reperfusion.
Stewart LC, Kelly RA, Atkinson DE, Ingwall JS
pH heterogeneity in aged hypertensive rat hearts distinguishes reperfused from persistently ischemic myocardium. J Mol Cell Cardiol. 1995 Jan; 27(1):321-33.
pH heterogeneity in aged hypertensive rat hearts distinguishes reperfused from persistently ischemic myocardium.
Gnecchi M, He H, Noiseux N, Liang OD, Zhang L, Morello F, Mu H, Melo LG, Pratt RE, Ingwall JS, Dzau VJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J. 2006 Apr; 20(6):661-9.
Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement.
Perry SB, McAuliffe J, Balschi JA, Hickey PR, Ingwall JS
Velocity of the creatine kinase reaction in the neonatal rabbit heart: role of mitochondrial creatine kinase. Biochemistry. 1988 Mar 22; 27(6):2165-72.
Velocity of the creatine kinase reaction in the neonatal rabbit heart: role of mitochondrial creatine kinase.
Reduction of protein degradation and atrophy in cultured fetal mouse hearts by leupeptin. Am J Physiol. 1979 Jul; 237(1):E35-9.
Reduction of protein degradation and atrophy in cultured fetal mouse hearts by leupeptin.
Ouellette AJ, Watson RK, Billmire K, Dygert MK, Ingwall JS
Protein synthesis in the cultured fetal mouse heart: effects of deprivation of oxygen and oxidizable substrate. Biochemistry. 1983 Mar 01; 22(5):1201-7.
Protein synthesis in the cultured fetal mouse heart: effects of deprivation of oxygen and oxidizable substrate.
Spindler M, Saupe KW, Christe ME, Sweeney HL, Seidman CE, Seidman JG, Ingwall JS
Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy. J Clin Invest. 1998 Apr 15; 101(8):1775-83.
Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy.
Saupe KW, Eberli FR, Ingwall JS, Apstein CS
Hypoperfusion-induced contractile failure does not require changes in cardiac energetics. Am J Physiol. 1999 05; 276(5):H1715-23.
Hypoperfusion-induced contractile failure does not require changes in cardiac energetics.
Abel ED, Kaulbach HC, Tian R, Hopkins JC, Duffy J, Doetschman T, Minnemann T, Boers ME, Hadro E, Oberste-Berghaus C, Quist W, Lowell BB, Ingwall JS, Kahn BB
Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. J Clin Invest. 1999 Dec; 104(12):1703-14.
Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart.
Mechanism of action of 2,3-butanedione monoxime on contracture during metabolic inhibition. Am J Physiol. 1994 Jul; 267(1 Pt 2):H100-8.
Mechanism of action of 2,3-butanedione monoxime on contracture during metabolic inhibition.
Ingwall JS, Atkinson DE, Clarke K, Fetters JK
Energetic correlates of cardiac failure: changes in the creatine kinase system in the failing myocardium. Eur Heart J. 1990 Apr; 11 Suppl B:108-15.
Energetic correlates of cardiac failure: changes in the creatine kinase system in the failing myocardium.
Neubauer S, Hamman BL, Perry SB, Bittl JA, Ingwall JS
Velocity of the creatine kinase reaction decreases in postischemic myocardium: a 31P-NMR magnetization transfer study of the isolated ferret heart. Circ Res. 1988 Jul; 63(1):1-15.
Velocity of the creatine kinase reaction decreases in postischemic myocardium: a 31P-NMR magnetization transfer study of the isolated ferret heart.
Goldhaber SZ, Pohost GM, Kloner RA, Andrews E, Newell JB, Ingwall JS
Inosine: a protective agent in an organ culture model of myocardial ischemia. Circ Res. 1982 Aug; 51(2):181-8.
Inosine: a protective agent in an organ culture model of myocardial ischemia.
Recent advances in studies on cardiac structure and metabolism
Autophagy in cardiac myocytes. Recent Adv Stud Cardiac Struct Metab. 1976 May 26-29; 12:453-63.
Halperin JA, Brugnara C, Kopin AS, Ingwall J, Tosteson DC
Properties of the Na+-K+ pump in human red cells with increased number of pump sites. J Clin Invest. 1987 Jul; 80(1):128-37.
Properties of the Na+-K+ pump in human red cells with increased number of pump sites.
Ahmad F, Arad M, Musi N, He H, Wolf C, Branco D, Perez-Atayde AR, Stapleton D, Bali D, Xing Y, Tian R, Goodyear LJ, Berul CI, Ingwall JS, Seidman CE, Seidman JG
Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy. Circulation. 2005 Nov 15; 112(20):3140-8.
Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy.
Archives des maladies du coeur et des vaisseaux
Energetics of the failing heart: new insights using genetic modification in the mouse. Arch Mal Coeur Vaiss. 2006 Sep; 99(9):839-47.
Energetics of the failing heart: new insights using genetic modification in the mouse.
On the hypothesis that the failing heart is energy starved: lessons learned from the metabolism of ATP and creatine. Curr Hypertens Rep. 2006 Dec; 8(6):457-64.
On the hypothesis that the failing heart is energy starved: lessons learned from the metabolism of ATP and creatine.
O'Brien SE, Apkon M, Berul CI, Patel HT, Saupe K, Spindler M, Ingwall JS, Zahler R
Phenotypical features of long Q-T syndrome in transgenic mice expressing human Na-K-ATPase alpha(3)-isoform in hearts. Am J Physiol Heart Circ Physiol. 2000 Nov; 279(5):H2133-42.
Phenotypical features of long Q-T syndrome in transgenic mice expressing human Na-K-ATPase alpha(3)-isoform in hearts.
Hoyer K, Song Y, Wang D, Phan D, Balschi J, Ingwall JS, Belardinelli L, Shryock JC
The Journal of pharmacology and experimental therapeutics
Reducing the late sodium current improves cardiac function during sodium pump inhibition by ouabain. J Pharmacol Exp Ther. 2011 May; 337(2):513-23.
Reducing the late sodium current improves cardiac function during sodium pump inhibition by ouabain.
Glucose-insulin-potassium therapy in patients with STEMI. JAMA. 2008 May 28; 299(20):2385; author reply 2387-8.
Glucose-insulin-potassium therapy in patients with STEMI.
Dzeja PP, Hoyer K, Tian R, Zhang S, Nemutlu E, Spindler M, Ingwall JS
Rearrangement of energetic and substrate utilization networks compensate for chronic myocardial creatine kinase deficiency. J Physiol. 2011 Nov 01; 589(Pt 21):5193-211.
Rearrangement of energetic and substrate utilization networks compensate for chronic myocardial creatine kinase deficiency.
On substrate selection for ATP synthesis in the failing human myocardium. Am J Physiol Heart Circ Physiol. 2007 Dec; 293(6):H3225-6.
On substrate selection for ATP synthesis in the failing human myocardium.
Spencer RG, Balschi JA, Leigh JS, Ingwall JS
ATP synthesis and degradation rates in the perfused rat heart. 31P-nuclear magnetic resonance double saturation transfer measurements. Biophys J. 1988 Nov; 54(5):921-9.
ATP synthesis and degradation rates in the perfused rat heart. 31P-nuclear magnetic resonance double saturation transfer measurements.
Ingwall JS, Weiner CD, Morales MF, Davis E, Stockdale FE
Specificity of creatine in the control of muscle protein synthesis. J Cell Biol. 1974 Jul; 62(1):145-51.
Specificity of creatine in the control of muscle protein synthesis.
Factors influencing enzyme release from cultured fetal mouse hearts deprived of oxygen and glucose. J Mol Cell Cardiol. 1978 Oct; 10(10):907-19.
Factors influencing enzyme release from cultured fetal mouse hearts deprived of oxygen and glucose.
31P nuclear magnetic resonance spectroscopic imaging of regions of remodeled myocardium in the infarcted rat heart. Circulation. 1995 Dec 15; 92(12):3527-38.
31P nuclear magnetic resonance spectroscopic imaging of regions of remodeled myocardium in the infarcted rat heart.
Rate equation for creatine kinase predicts the in vivo reaction velocity: 31P NMR surface coil studies in brain, heart, and skeletal muscle of the living rat. Biochemistry. 1987 Sep 22; 26(19):6083-90.
Rate equation for creatine kinase predicts the in vivo reaction velocity: 31P NMR surface coil studies in brain, heart, and skeletal muscle of the living rat.
Journal of the American College of Cardiology
Stabilization of a derangement in adenosine triphosphate metabolism during sustained, partial ischemia in the dog heart. J Am Coll Cardiol. 1986 Oct; 8(4):894-900.
Stabilization of a derangement in adenosine triphosphate metabolism during sustained, partial ischemia in the dog heart.
Pohost GM, Alpert NM, Ingwall JS, Strauss HW
Thallium redistribution: mechanisms and clinical utility. Semin Nucl Med. 1980 Jan; 10(1):70-93.
Thallium redistribution: mechanisms and clinical utility.
Braunwald E, DeBoer LW, Glogar DH, Darsee JR, Ertl G, Ingwall JS, Kloner RA
Observations on the experimental reduction of infarct size and on the delayed consequences of transient myocardial ischemia. Acta Med Scand Suppl. 1981; 651:123-32.
Observations on the experimental reduction of infarct size and on the delayed consequences of transient myocardial ischemia.
Phosphorus nuclear magnetic resonance spectroscopy of cardiac and skeletal muscles. Am J Physiol. 1982 May; 242(5):H729-44.
Phosphorus nuclear magnetic resonance spectroscopy of cardiac and skeletal muscles.
Shen W, Vatner DE, Vatner SF, Ingwall JS
Progressive loss of creatine maintains a near normal DeltaG approximately (ATP) in transgenic mouse hearts with cardiomyopathy caused by overexpressing Gsalpha. J Mol Cell Cardiol. 2010 Apr; 48(4):591-9.
Progressive loss of creatine maintains a near normal DeltaG approximately (ATP) in transgenic mouse hearts with cardiomyopathy caused by overexpressing Gsalpha.
Rice R, Guinto P, Dowell-Martino C, He H, Hoyer K, Krenz M, Robbins J, Ingwall JS, Tardiff JC
Cardiac myosin heavy chain isoform exchange alters the phenotype of cTnT-related cardiomyopathies in mouse hearts. J Mol Cell Cardiol. 2010 May; 48(5):979-88.
Cardiac myosin heavy chain isoform exchange alters the phenotype of cTnT-related cardiomyopathies in mouse hearts.
DeBoer LW, Ingwall JS, Kloner RA, Braunwald E
Prolonged derangements of canine myocardial purine metabolism after a brief coronary artery occlusion not associated with anatomic evidence of necrosis. Proc Natl Acad Sci U S A. 1980 Sep; 77(9):5471-5.
Prolonged derangements of canine myocardial purine metabolism after a brief coronary artery occlusion not associated with anatomic evidence of necrosis.
Pernot AC, Ingwall JS, Menasche P, Grousset C, Bercot M, Mollet M, Piwnica A, Fossel ET
Limitations of potassium cardioplegia during cardiac ischemic arrest: a phosphorus 31 nuclear magnetic resonance study. Ann Thorac Surg. 1981 Dec; 32(6):536-45.
Limitations of potassium cardioplegia during cardiac ischemic arrest: a phosphorus 31 nuclear magnetic resonance study.
Creatine and the control of muscle-specific protein synthesis in cardiac and skeletal muscle. Circ Res. 1976 May; 38(5 Suppl 1):I115-23.
Creatine and the control of muscle-specific protein synthesis in cardiac and skeletal muscle.
Reaction rates of creatine kinase and ATP synthesis in the isolated rat heart. A 31P NMR magnetization transfer study. J Biol Chem. 1985 Mar 25; 260(6):3512-7.
Reaction rates of creatine kinase and ATP synthesis in the isolated rat heart. A 31P NMR magnetization transfer study.
The hypertrophied myocardium accumulates the MB-creatine kinase isozyme. Eur Heart J. 1984 Dec; 5 Suppl F:129-39.
The hypertrophied myocardium accumulates the MB-creatine kinase isozyme.
DeLayre JL, Ingwall JS, Malloy C, Fossel ET
Gated sodium-23 nuclear magnetic resonance images of an isolated perfused working rat heart. Science. 1981 May 22; 212(4497):935-6.
Gated sodium-23 nuclear magnetic resonance images of an isolated perfused working rat heart.
Laboratory investigation; a journal of technical methods and pathology
Fetal mouse heart in organ structure: ultrastructure. Lab Invest. 1975 Jun; 32(6):713-9.
Fetal mouse heart in organ structure: ultrastructure.
Clarke K, Stewart LC, Neubauer S, Balschi JA, Smith TW, Ingwall JS, Nédélec JF, Humphrey SM, Kléber AG, Springer CS
Extracellular volume and transsarcolemmal proton movement during ischemia and reperfusion: a 31P NMR spectroscopic study of the isovolumic rat heart. NMR Biomed. 1993 Jul-Aug; 6(4):278-86.
Extracellular volume and transsarcolemmal proton movement during ischemia and reperfusion: a 31P NMR spectroscopic study of the isovolumic rat heart.
Measurement of changes in high-energy phosphates in the cardiac cycle using gated 31P nuclear magnetic renonance. Proc Natl Acad Sci U S A. 1980 Jun; 77(6):3654-8.
Measurement of changes in high-energy phosphates in the cardiac cycle using gated 31P nuclear magnetic renonance.
Mann DV, Robinson MK, Rounds JD, DeRosa E, Niles DA, Ingwall JS, Wilmore DW, Jacobs DO
Superiority of blood over saline resuscitation from hemorrhagic shock: a 31P magnetic resonance spectroscopy study. Ann Surg. 1997 Nov; 226(5):653-61.
Superiority of blood over saline resuscitation from hemorrhagic shock: a 31P magnetic resonance spectroscopy study.
Regulation of cardiac AMP-specific 5'-nucleotidase during ischemia mediates ATP resynthesis on reflow. Am J Physiol. 1998 04; 274(4):C992-1001.
Regulation of cardiac AMP-specific 5'-nucleotidase during ischemia mediates ATP resynthesis on reflow.
Menasché P, Piwnica A, Ingwall JS, Fossel ET
[A new method to evaluate myocardial preservation techniques (author's transl)]. Nouv Presse Med. 1981 Feb 07; 10(5):295-8.
[A new method to evaluate myocardial preservation techniques (author's transl)].
Ingwall JS, DeLuca M, Sybers HD, Wildenthal K
Fetal mouse hearts: a model for studying ischemia. Proc Natl Acad Sci U S A. 1975 Jul; 72(7):2809-13.
Fetal mouse hearts: a model for studying ischemia.
Acidosis during ischemia promotes adenosine triphosphate resynthesis in postischemic rat heart. In vivo regulation of 5'-nucleotidase. J Clin Invest. 1994 Jan; 93(1):40-9.
Acidosis during ischemia promotes adenosine triphosphate resynthesis in postischemic rat heart. In vivo regulation of 5'-nucleotidase.
Gross WL, Bak MI, Ingwall JS, Arstall MA, Smith TW, Balligand JL, Kelly RA
Nitric oxide inhibits creatine kinase and regulates rat heart contractile reserve. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5604-9.
Nitric oxide inhibits creatine kinase and regulates rat heart contractile reserve.
Hormonal control of cardiac protein and amino acid balance. Circ Res. 1976 May; 38(5 Suppl 1):I138-44.
Hormonal control of cardiac protein and amino acid balance.
Tian R, Nascimben L, Kaddurah-Daouk R, Ingwall JS
Depletion of energy reserve via the creatine kinase reaction during the evolution of heart failure in cardiomyopathic hamsters. J Mol Cell Cardiol. 1996 Apr; 28(4):755-65.
Depletion of energy reserve via the creatine kinase reaction during the evolution of heart failure in cardiomyopathic hamsters.
Norwood WI, Norwood CR, Ingwall JS, Castaneda AR, Fossel ET
The Journal of thoracic and cardiovascular surgery
Hypothermic circulatory arrest: 31-phosphorus nuclear magnetic resonsance of isolated perfused neonatal rat brain. J Thorac Cardiovasc Surg. 1979 Dec; 78(6):823-30.
Hypothermic circulatory arrest: 31-phosphorus nuclear magnetic resonsance of isolated perfused neonatal rat brain.
Hamman BL, Bittl JA, Jacobus WE, Allen PD, Spencer RS, Tian R, Ingwall JS
Inhibition of the creatine kinase reaction decreases the contractile reserve of isolated rat hearts. Am J Physiol. 1995 Sep; 269(3 Pt 2):H1030-6.
Inhibition of the creatine kinase reaction decreases the contractile reserve of isolated rat hearts.
How high does intracellular sodium rise during acute myocardial ischaemia? A view from NMR spectroscopy. Cardiovasc Res. 1995 Feb; 29(2):279.
How high does intracellular sodium rise during acute myocardial ischaemia? A view from NMR spectroscopy.
Momomura S, Ingwall JS, Parker JA, Sahagian P, Ferguson JJ, Grossman W
The relationships of high energy phosphates, tissue pH, and regional blood flow to diastolic distensibility in the ischemic dog myocardium. Circ Res. 1985 Dec; 57(6):822-35.
The relationships of high energy phosphates, tissue pH, and regional blood flow to diastolic distensibility in the ischemic dog myocardium.
Neubauer S, Horn M, Naumann A, Tian R, Hu K, Laser M, Friedrich J, Gaudron P, Schnackerz K, Ingwall JS
Impairment of energy metabolism in intact residual myocardium of rat hearts with chronic myocardial infarction. J Clin Invest. 1995 Mar; 95(3):1092-100.
Impairment of energy metabolism in intact residual myocardium of rat hearts with chronic myocardial infarction.
NMR-invisible ATP in heart: fact or fiction? Am J Physiol. 1992 Jun; 262(6 Pt 1):E943-7.
NMR-invisible ATP in heart: fact or fiction?
Lange R, Ingwall JS, Hale SL, Alker KJ, Kloner RA
Effects of recurrent ischemia on myocardial high energy phosphate content in canine hearts. Basic Res Cardiol. 1984 Jul-Aug; 79(4):469-78.
Effects of recurrent ischemia on myocardial high energy phosphate content in canine hearts.
Glass MG, Fuleihan F, Liao R, Lincoff AM, Chapados R, Hamlin R, Apstein CS, Allen PD, Ingwall JS, Hajjar RJ
Differences in cardioprotective efficacy of adrenergic receptor antagonists and Ca2+ channel antagonists in an animal model of dilated cardiomyopathy. Effects on gross morphology, global cardiac function, and twitch force. Circ Res. 1993 Dec; 73(6):1077-89.
Differences in cardioprotective efficacy of adrenergic receptor antagonists and Ca2+ channel antagonists in an animal model of dilated cardiomyopathy. Effects on gross morphology, global cardiac function, and twitch force.
Stewart L, Hamilton C, Ingwall J, Naomi S, Graves S, Canessa M, Williams G, Hollenberg N
Vascular smooth muscle response to ouabain. Relation of tissue Na+ to the contractile response. Circ Res. 1993 Dec; 73(6):1113-20.
Vascular smooth muscle response to ouabain. Relation of tissue Na+ to the contractile response.
Purification and properties of bovine prothrombin. Biochemistry. 1969 May; 8(5):1860-9.
Purification and properties of bovine prothrombin.
Lange R, Ingwall J, Hale SL, Alker KJ, Braunwald E, Kloner RA
Preservation of high-energy phosphates by verapamil in reperfused myocardium. Circulation. 1984 Oct; 70(4):734-41.
Preservation of high-energy phosphates by verapamil in reperfused myocardium.
Conrad CH, Brooks WW, Ingwall JS, Bing OH
Inhibition of hypoxic myocardial contracture by Cobalt in the rat. J Mol Cell Cardiol. 1984 Apr; 16(4):345-54.
Inhibition of hypoxic myocardial contracture by Cobalt in the rat.
On the control of metabolic remodeling in mitochondria of the failing heart. Circ Heart Fail. 2009 Jul; 2(4):275-7.
On the control of metabolic remodeling in mitochondria of the failing heart.
Norwood WI, Ingwall JS, Norwood CR, Fossel ET
Developmental changes of creatine kinase metabolism in rat brain. Am J Physiol. 1983 Mar; 244(3):C205-10.
Developmental changes of creatine kinase metabolism in rat brain.
The cell substratum modulates skeletal muscle differentiation. J Supramol Struct. 1980; 14(3):313-28.
The cell substratum modulates skeletal muscle differentiation.
Comparison of twitch force and calcium handling in papillary muscles from right ventricular pressure overload hypertrophy in weanling and juvenile ferrets. Cardiovasc Res. 1995 Apr; 29(4):475-81.
Comparison of twitch force and calcium handling in papillary muscles from right ventricular pressure overload hypertrophy in weanling and juvenile ferrets.
Nascimben L, Friedrich J, Liao R, Pauletto P, Pessina AC, Ingwall JS
Enalapril treatment increases cardiac performance and energy reserve via the creatine kinase reaction in myocardium of Syrian myopathic hamsters with advanced heart failure. Circulation. 1995 Mar 15; 91(6):1824-33.
Enalapril treatment increases cardiac performance and energy reserve via the creatine kinase reaction in myocardium of Syrian myopathic hamsters with advanced heart failure.
Laser A, Ingwall JS, Tian R, Reis I, Hu K, Gaudron P, Ertl G, Neubauer S
Regional biochemical remodeling in non-infarcted tissue of rat heart post-myocardial infarction. J Mol Cell Cardiol. 1996 Jul; 28(7):1531-8.
Regional biochemical remodeling in non-infarcted tissue of rat heart post-myocardial infarction.
Ingwall JS, Morales MF, Stockdale FE, Wildenthal K
Creatine: a possible stimulus skeletal cardiac muscle hypertrophy. Recent Adv Stud Cardiac Struct Metab. 1975; 8:467-81.
Creatine: a possible stimulus skeletal cardiac muscle hypertrophy.
Mangi AA, Noiseux N, Kong D, He H, Rezvani M, Ingwall JS, Dzau VJ
Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med. 2003 Sep; 9(9):1195-201.
Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts.
Smith SH, Kramer MF, Reis I, Bishop SP, Ingwall JS
Regional changes in creatine kinase and myocyte size in hypertensive and nonhypertensive cardiac hypertrophy. Circ Res. 1990 Dec; 67(6):1334-44.
Regional changes in creatine kinase and myocyte size in hypertensive and nonhypertensive cardiac hypertrophy.
Balschi JA, Bittl JA, Springer CS, Ingwall JS
31P and 23Na NMR spectroscopy of normal and ischemic rat skeletal muscle. Use of a shift reagent in vivo. NMR Biomed. 1990 Apr; 3(2):47-58.
31P and 23Na NMR spectroscopy of normal and ischemic rat skeletal muscle. Use of a shift reagent in vivo.
Springer CS, Pike MM, Balschi JA, Chu SC, Frazier JC, Ingwall JS, Smith TW
Use of shift reagents for nuclear magnetic resonance studies of the kinetics of ion transfer in cells and perfused hearts. Circulation. 1985 Nov; 72(5 Pt 2):IV89-93.
Use of shift reagents for nuclear magnetic resonance studies of the kinetics of ion transfer in cells and perfused hearts.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Effects of moderate pressure overload cardiac hypertrophy on the distribution of creatine kinase isozymes. Proc Soc Exp Biol Med. 1984 Jan; 175(1):5-9.
Effects of moderate pressure overload cardiac hypertrophy on the distribution of creatine kinase isozymes.
Role of creatine in the regulation of cardiac protein synthesis. J Cell Biol. 1976 Jan; 68(1):159-63.
Role of creatine in the regulation of cardiac protein synthesis.
Professor of Stem Cell and Regenerative Biology
Corresponding Member of the Faculty of Psychiatry
Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics
The energetic cost of contraction is higher in the myocardium of patients with hypertrophic cardiomyopathy. Cardiovasc Res. 2014 Jul 15; 103(2):192-3.
The energetic cost of contraction is higher in the myocardium of patients with hypertrophic cardiomyopathy.
Exploring the Role of CTnT in Sarcomere Function
SPECIALIZED CENTER OF RESEARCH IN ISCHEMIC HEART DISEASE
SPECIALIZED CENTER OF RESEARCH IN HEART FAILURE
ENERGETICS &CATION MOVEMENTS IN POSTISCHEMIC HEART
INTRACELLULAR PH REGULATION IN ISCHEMIC MYOCARDIUM
Nascimben L, Ingwall JS, Pauletto P, Friedrich J, Gwathmey JK, Saks V, Pessina AC, Allen PD
Creatine kinase system in failing and nonfailing human myocardium. Circulation. 1996 Oct 15; 94(8):1894-901.
Creatine kinase system in failing and nonfailing human myocardium.
Function and bioenergetics in isolated perfused trained rat hearts. Am J Physiol. 1997 Jan; 272(1 Pt 2):H409-17.
Function and bioenergetics in isolated perfused trained rat hearts.
Metabolic consequences and predictability of ventricular fibrillation in hypoxia. A 31P- and 23Na-nuclear magnetic resonance study of the isolated rat heart. Circulation. 1992 Jul; 86(1):302-10.
Metabolic consequences and predictability of ventricular fibrillation in hypoxia. A 31P- and 23Na-nuclear magnetic resonance study of the isolated rat heart.
Kohler SJ, Perry SB, Stewart LC, Atkinson DE, Clarke K, Ingwall JS
Analysis of 23Na NMR spectra from isolated perfused hearts. Magn Reson Med. 1991 Mar; 18(1):15-27.
Analysis of 23Na NMR spectra from isolated perfused hearts.
Creatine kinase knockout mice--what is the phenotype: heart. MAGMA. 1998 Sep; 6(2-3):120-1.
Creatine kinase knockout mice--what is the phenotype: heart.
Pachucki J, Hopkins J, Peeters R, Tu H, Carvalho SD, Kaulbach H, Abel ED, Wondisford FE, Ingwall JS, Larsen PR
Type 2 Iodothyronine Deiodinase Transgene Expression in the Mouse Heart Causes Cardiac-Specific Thyrotoxicosis**This work was supported by grants from the NIH [DK-36256 (to P.R.L.); DK-49126 and DK-53036 (to F.E.W.) and Specialized Center of Research Grant HL-52320 (to J.S.I.)]. Endocrinology. 2001 Jan 01; 142(1):13-20.
Type 2 Iodothyronine Deiodinase Transgene Expression in the Mouse Heart Causes Cardiac-Specific Thyrotoxicosis**This work was supported by grants from the NIH [DK-36256 (to P.R.L.); DK-49126 and DK-53036 (to F.E.W.) and Specialized Center of Research Grant HL-52320 (to J.S.I.)].
Tian R, Miao W, Spindler M, Javadpour MM, McKinney R, Bowman JC, Buttrick PM, Ingwall JS
Long-term expression of protein kinase C in adult mouse hearts improves postischemic recovery. Proc Natl Acad Sci U S A. 1999 Nov 09; 96(23):13536-41.
Long-term expression of protein kinase C in adult mouse hearts improves postischemic recovery.
Cave AC, Ingwall JS, Friedrich J, Liao R, Saupe KW, Apstein CS, Eberli FR
ATP synthesis during low-flow ischemia: influence of increased glycolytic substrate. Circulation. 2000 May 02; 101(17):2090-6.
ATP synthesis during low-flow ischemia: influence of increased glycolytic substrate.
Pinz I, Robbins J, Rajasekaran NS, Benjamin IJ, Ingwall JS
Unmasking different mechanical and energetic roles for the small heat shock proteins CryAB and HSPB2 using genetically modified mouse hearts. FASEB J. 2008 Jan; 22(1):84-92.
Unmasking different mechanical and energetic roles for the small heat shock proteins CryAB and HSPB2 using genetically modified mouse hearts.
Clinical and experimental pharmacology & physiology
Creatine kinase inhibitor iodoacetamide antagonizes calcium-stimulated inotropy in cardiomyocytes. Clin Exp Pharmacol Physiol. 2009 Feb; 36(2):141-5.
Creatine kinase inhibitor iodoacetamide antagonizes calcium-stimulated inotropy in cardiomyocytes.
MR spectroscopy of transgenic mice. MAGMA. 1998 Sep; 6(2-3):109-10.
Yet SF, Tian R, Layne MD, Wang ZY, Maemura K, Solovyeva M, Ith B, Melo LG, Zhang L, Ingwall JS, Dzau VJ, Lee ME, Perrella MA
Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ Res. 2001 Jul 20; 89(2):168-73.
Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice.
Is creatine kinase a target for AMP-activated protein kinase in the heart? J Mol Cell Cardiol. 2002 Sep; 34(9):1111-20.
Is creatine kinase a target for AMP-activated protein kinase in the heart?
The isolated, buffer-perfused ferret heart: a new model for the study of cardiac physiology and metabolism. Lab Anim. 1991 Oct; 25(4):348-53.
The isolated, buffer-perfused ferret heart: a new model for the study of cardiac physiology and metabolism.
Whole-organ enzymology of the creatine kinase system in heart. Biochem Soc Trans. 1991 Nov; 19(4):1006-10.
Whole-organ enzymology of the creatine kinase system in heart.
Neubauer S, Horn M, Cramer M, Harre K, Newell JB, Peters W, Pabst T, Ertl G, Hahn D, Ingwall JS, Kochsiek K
Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy. Circulation. 1997 Oct 07; 96(7):2190-6.
Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy.
Do the FHC-associated R403 mutations in myosin heavy chain lead to a greater energetic cost of contraction? J Mol Cell Cardiol. 2004 Mar; 36(3):327-30.
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