SCH1StephenHarrisonStephen Coplan Harrison, Ph.D.42.33738860000000-71.1043729000000074002Harrison, StephenCoplan617/432-5609Giovanni Armenise - Harvard Professor of Basic Biomedical Sciencecatalyst:advisorInMentoringCompletedStudentProjectcompleted student projectscatalyst:eCommonsLogineCommons LoginMentoring - Completed Student Projectprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:overviewoverviewvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson10364331Ferrer M, Harrison SCJournal of virologyPeptide ligands to human immunodeficiency virus type 1 gp120 identified from phage display libraries. J Virol. 1999 Jul; 73(7):5795-802.J Virol1999-07-01T00:00:001999Peptide ligands to human immunodeficiency virus type 1 gp120 identified from phage display libraries.11462006Dormitzer PR, Greenberg HB, Harrison SCJournal of virologyProteolysis of monomeric recombinant rotavirus VP4 yields an oligomeric VP5* core. J Virol. 2001 Aug; 75(16):7339-50.J Virol2001-08-01T00:00:002001Proteolysis of monomeric recombinant rotavirus VP4 yields an oligomeric VP5* core.10504731Ferrer M, Kapoor TM, Strassmaier T, Weissenhorn W, Skehel JJ, Oprian D, Schreiber SL, Wiley DC, Harrison SCNature structural biologySelection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements. Nat Struct Biol. 1999 Oct; 6(10):953-60.Nat Struct Biol1999-10-01T00:00:001999Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements.10655490ter Haar E, Harrison SC, Kirchhausen TProceedings of the National Academy of Sciences of the United States of AmericaPeptide-in-groove interactions link target proteins to the beta-propeller of clathrin. Proc Natl Acad Sci U S A. 2000 Feb 01; 97(3):1096-100.Proc Natl Acad Sci U S A2000-02-01T00:00:002000Peptide-in-groove interactions link target proteins to the beta-propeller of clathrin.10801473Huang H, Harrison SC, Verdine GLChemistry & biologyTrapping of a catalytic HIV reverse transcriptase*template:primer complex through a disulfide bond. Chem Biol. 2000 May; 7(5):355-64.Chem Biol2000-05-01T00:00:002000Trapping of a catalytic HIV reverse transcriptase*template:primer complex through a disulfide bond.11864596Harrison SCMolecular cellDon C. Wiley (1944--2001). Mol Cell. 2002 Feb; 9(2):225-7.Mol Cell2002-02-01T00:00:002002Don C. Wiley (1944--2001).173853Jack A, Harrison SCJournal of molecular biologyOn the interpretation of small-angle x-ray solution scattering from spherical viruses. J Mol Biol. 1975 Nov 25; 99(1):15-25.J Mol Biol1975-11-25T00:00:001975On the interpretation of small-angle x-ray solution scattering from spherical viruses.Authorship 10522801329549260Fera D, Lee MS, Wiehe K, Meyerhoff RR, Piai A, Bonsignori M, Aussedat B, Walkowicz WE, Ton T, Zhou JO, Danishefsky S, Haynes BF, Harrison SCNature communicationsHIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope. Nat Commun. 2018 03 16; 9(1):1111.Nat Commun2018-03-16T00:00:002018HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope.6481803Hopper P, Harrison SC, Sauer RTJournal of molecular biologyStructure of tomato bushy stunt virus. V. Coat protein sequence determination and its structural implications. J Mol Biol. 1984 Aug 25; 177(4):701-13.J Mol Biol1984-08-25T00:00:001984Structure of tomato bushy stunt virus. V. Coat protein sequence determination and its structural implications.15510218Panne D, Maniatis T, Harrison SCThe EMBO journalCrystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer. EMBO J. 2004 Nov 10; 23(22):4384-93.EMBO J2004-10-28T00:00:002004Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer.3372526Turkewitz AP, Amatruda JF, Borhani D, Harrison SC, Schwartz ALThe Journal of biological chemistryA high yield purification of the human transferrin receptor and properties of its major extracellular fragment. J Biol Chem. 1988 Jun 15; 263(17):8318-25.J Biol Chem1988-06-15T00:00:001988A high yield purification of the human transferrin receptor and properties of its major extracellular fragment.7138809Golden JS, Harrison SCBiochemistryProteolytic dissection of turnip crinkle virus subunit in solution. Biochemistry. 1982 Aug 03; 21(16):3862-6.Biochemistry1982-08-03T00:00:001982Proteolytic dissection of turnip crinkle virus subunit in solution.8538787Berger JM, Gamblin SJ, Harrison SC, Wang JCNatureStructure and mechanism of DNA topoisomerase II. Nature. 1996 Jan 18; 379(6562):225-32.Nature1996-01-18T00:00:001996Structure and mechanism of DNA topoisomerase II.8681956Weissenhorn W, Eck MJ, Harrison SC, Wiley DCEuropean journal of biochemistryPhosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitro. Eur J Biochem. 1996 Jun 01; 238(2):440-5.Eur J Biochem1996-06-01T00:00:001996Phosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitro.Authorship 10586251177320Harrison SC, Jack AJournal of molecular biologyStructure of tomato bushy stunt virus. Three-dimensional x-ray diffraction analysis at 16 A resolution. J Mol Biol. 1975 Sep 15; 97(2):173-91.J Mol Biol1975-09-15T00:00:001975Structure of tomato bushy stunt virus. Three-dimensional x-ray diffraction analysis at 16 A resolution.17997968Bellizzi JJ, Sorger PK, Harrison SCStructure (London, England : 1993)Crystal structure of the yeast inner kinetochore subunit Cep3p. Structure. 2007 Nov; 15(11):1422-30.Structure2007-11-01T00:00:002007Crystal structure of the yeast inner kinetochore subunit Cep3p.12357034Jin L, Harrison SCProceedings of the National Academy of Sciences of the United States of AmericaCrystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13522-6.Proc Natl Acad Sci U S A2002-09-30T00:00:002002Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin.20881042Schmidt AG, Yang PL, Harrison SCJournal of virologyPeptide inhibitors of flavivirus entry derived from the E protein stem. J Virol. 2010 Dec; 84(24):12549-54.J Virol2010-09-29T00:00:002010Peptide inhibitors of flavivirus entry derived from the E protein stem.15544799Larsen NA, Harrison SCJournal of molecular biologyCrystal structure of the spindle assembly checkpoint protein Bub3. J Mol Biol. 2004 Dec 03; 344(4):885-92.J Mol Biol2004-12-03T00:00:002004Crystal structure of the spindle assembly checkpoint protein Bub3.20033059Xing Y, Böcking T, Wolf M, Grigorieff N, Kirchhausen T, Harrison SCThe EMBO journalStructure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly. EMBO J. 2010 Feb 03; 29(3):655-65.EMBO J2009-12-24T00:00:002009Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly.20708587Al-Bassam J, Kim H, Brouhard G, van Oijen A, Harrison SC, Chang FDevelopmental cellCLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule. Dev Cell. 2010 Aug 17; 19(2):245-58.Dev Cell2010-08-17T00:00:002010CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule.21606327Cho US, Harrison SCProceedings of the National Academy of Sciences of the United States of AmericaRecognition of the centromere-specific histone Cse4 by the chaperone Scm3. Proc Natl Acad Sci U S A. 2011 Jun 07; 108(23):9367-71.Proc Natl Acad Sci U S A2011-05-23T00:00:002011Recognition of the centromere-specific histone Cse4 by the chaperone Scm3.23175789Schmidt AG, Xu H, Khan AR, O'Donnell T, Khurana S, King LR, Manischewitz J, Golding H, Suphaphiphat P, Carfi A, Settembre EC, Dormitzer PR, Kepler TB, Zhang R, Moody MA, Haynes BF, Liao HX, Shaw DE, Harrison SCProceedings of the National Academy of Sciences of the United States of AmericaPreconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):264-9.Proc Natl Acad Sci U S A2012-11-21T00:00:002012Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.Authorship 1062187229724956Jenni S, Harrison SCScience (New York, N.Y.)Structure of the DASH/Dam1 complex shows its role at the yeast kinetochore-microtubule interface. Science. 2018 05 04; 360(6388):552-558.Science2018-05-04T00:00:002018Structure of the DASH/Dam1 complex shows its role at the yeast kinetochore-microtubule interface.Authorship 10391523359001Harrison SC, Anderson JE, Koudelka GB, Mondragon A, Subbiah S, Wharton RP, Wolberger C, Ptashne MBiophysical chemistryRecognition of DNA sequences by the repressor of bacteriophage 434. Biophys Chem. 1988 Feb; 29(1-2):31-7.Biophys Chem1988-02-01T00:00:001988Recognition of DNA sequences by the repressor of bacteriophage 434.2145515Weiss MA, Ellenberger T, Wobbe CR, Lee JP, Harrison SC, Struhl KNatureFolding transition in the DNA-binding domain of GCN4 on specific binding to DNA. Nature. 1990 Oct 11; 347(6293):575-8.Nature1990-10-11T00:00:001990Folding transition in the DNA-binding domain of GCN4 on specific binding to DNA.722862von Bonsdorff CH, Harrison SCJournal of virologyHexagonal glycoprotein arrays from Sindbis virus membranes. J Virol. 1978 Nov; 28(2):578-83.J Virol1978-11-01T00:00:001978Hexagonal glycoprotein arrays from Sindbis virus membranes.7641872Müller CW, Harrison SCFEBS lettersThe structure of the NF-kappa B p50:DNA-complex: a starting point for analyzing the Rel family. FEBS Lett. 1995 Aug 01; 369(1):113-7.FEBS Lett1995-08-01T00:00:001995The structure of the NF-kappa B p50:DNA-complex: a starting point for analyzing the Rel family.7958913Marmorstein R, Harrison SCGenes & developmentCrystal structure of a PPR1-DNA complex: DNA recognition by proteins containing a Zn2Cys6 binuclear cluster. Genes Dev. 1994 Oct 15; 8(20):2504-12.Genes Dev1994-10-15T00:00:001994Crystal structure of a PPR1-DNA complex: DNA recognition by proteins containing a Zn2Cys6 binuclear cluster.16567500Al-Bassam J, van Breugel M, Harrison SC, Hyman AThe Journal of cell biologyStu2p binds tubulin and undergoes an open-to-closed conformational change. J Cell Biol. 2006 Mar 27; 172(7):1009-22.J Cell Biol2006-03-27T00:00:002006Stu2p binds tubulin and undergoes an open-to-closed conformational change.17005655Zhang L, Chandran K, Nibert ML, Harrison SCJournal of virologyReovirus mu1 structural rearrangements that mediate membrane penetration. J Virol. 2006 Dec; 80(24):12367-76.J Virol2006-09-27T00:00:002006Reovirus mu1 structural rearrangements that mediate membrane penetration.18596815Harrison SCNature structural & molecular biologyViral membrane fusion. Nat Struct Mol Biol. 2008 Jul; 15(7):690-8.Nat Struct Mol Biol2008-07-01T00:00:002008Viral membrane fusion.2685324Subbiah S, Harrison SCJournal of molecular biologyA method for multiple sequence alignment with gaps. J Mol Biol. 1989 Oct 20; 209(4):539-48.J Mol Biol1989-10-20T00:00:001989A method for multiple sequence alignment with gaps.12464184Tao Y, Farsetta DL, Nibert ML, Harrison SCCellRNA synthesis in a cage--structural studies of reovirus polymerase lambda3. Cell. 2002 Nov 27; 111(5):733-45.Cell2002-11-27T00:00:002002RNA synthesis in a cage--structural studies of reovirus polymerase lambda3.12517336Sliz P, Harrison SC, Rosenbaum GStructure (London, England : 1993)How does radiation damage in protein crystals depend on X-ray dose? Structure. 2003 Jan; 11(1):13-9.Structure2003-01-01T00:00:002003How does radiation damage in protein crystals depend on X-ray dose?12654240Harrison SCCellVariation on an Src-like theme. Cell. 2003 Mar 21; 112(6):737-40.Cell2003-03-21T00:00:002003Variation on an Src-like theme.Authorship 1044335Authorship 105565614737159Modis Y, Ogata S, Clements D, Harrison SCNatureStructure of the dengue virus envelope protein after membrane fusion. Nature. 2004 Jan 22; 427(6972):313-9.Nature2004-01-22T00:00:002004Structure of the dengue virus envelope protein after membrane fusion.15010214Kim J, Tao Y, Reinisch KM, Harrison SC, Nibert MLVirus researchOrthoreovirus and Aquareovirus core proteins: conserved enzymatic surfaces, but not protein-protein interfaces. Virus Res. 2004 Apr; 101(1):15-28.Virus Res2004-04-01T00:00:002004Orthoreovirus and Aquareovirus core proteins: conserved enzymatic surfaces, but not protein-protein interfaces.17037534Li F, Li W, Farzan M, Harrison SCAdvances in experimental medicine and biologyInteractions between SARS coronavirus and its receptor. Adv Exp Med Biol. 2006; 581:229-34.Adv Exp Med Biol2006-01-01T00:00:002006Interactions between SARS coronavirus and its receptor.1465431Moebius U, Clayton LK, Abraham S, Diener A, Yunis JJ, Harrison SC, Reinherz ELProceedings of the National Academy of Sciences of the United States of AmericaHuman immunodeficiency virus gp120 binding C'C" ridge of CD4 domain 1 is also involved in interaction with class II major histocompatibility complex molecules. Proc Natl Acad Sci U S A. 1992 Dec 15; 89(24):12008-12.Proc Natl Acad Sci U S A1992-12-15T00:00:001992Human immunodeficiency virus gp120 binding C'C" ridge of CD4 domain 1 is also involved in interaction with class II major histocompatibility complex molecules.NX7NingXiaNing Xia, M.D., Ph.D.170624Xia, NingResearch Fellow in Neurology1716695Heinz FX, Mandl CW, Holzmann H, Kunz C, Harris BA, Rey F, Harrison SCJournal of virologyThe flavivirus envelope protein E: isolation of a soluble form from tick-borne encephalitis virus and its crystallization. J Virol. 1991 Oct; 65(10):5579-83.J Virol1991-10-01T00:00:001991The flavivirus envelope protein E: isolation of a soluble form from tick-borne encephalitis virus and its crystallization.8668194Liang SD, Marmorstein R, Harrison SC, Ptashne MMolecular and cellular biologyDNA sequence preferences of GAL4 and PPR1: how a subset of Zn2 Cys6 binuclear cluster proteins recognizes DNA. Mol Cell Biol. 1996 Jul; 16(7):3773-80.Mol Cell Biol1996-07-01T00:00:001996DNA sequence preferences of GAL4 and PPR1: how a subset of Zn2 Cys6 binuclear cluster proteins recognizes DNA.21333526Grigorieff N, Harrison SCCurrent opinion in structural biologyNear-atomic resolution reconstructions of icosahedral viruses from electron cryo-microscopy. Curr Opin Struct Biol. 2011 Apr; 21(2):265-73.Curr Opin Struct Biol2011-02-18T00:00:002011Near-atomic resolution reconstructions of icosahedral viruses from electron cryo-microscopy.22366277Brilot AF, Chen JZ, Cheng A, Pan J, Harrison SC, Potter CS, Carragher B, Henderson R, Grigorieff NJournal of structural biologyBeam-induced motion of vitrified specimen on holey carbon film. J Struct Biol. 2012 Mar; 177(3):630-7.J Struct Biol2012-02-16T00:00:002012Beam-induced motion of vitrified specimen on holey carbon film.22813733Corbett KD, Harrison SCCell reportsMolecular architecture of the yeast monopolin complex. Cell Rep. 2012 Jun 28; 1(6):583-9.Cell Rep2012-06-21T00:00:002012Molecular architecture of the yeast monopolin complex.13679521Espelin CW, Simons KT, Harrison SC, Sorger PKMolecular biology of the cellBinding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII. Mol Biol Cell. 2003 Nov; 14(11):4557-68.Mol Biol Cell2003-09-17T00:00:002003Binding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII.14718917Harrison SCNature structural & molecular biologyWhither structural biology? Nat Struct Mol Biol. 2004 Jan; 11(1):12-5.Nat Struct Mol Biol2004-01-01T00:00:002004Whither structural biology?16343946Cheng Y, Zak O, Aisen P, Harrison SC, Walz TJournal of structural biologySingle particle reconstruction of the human apo-transferrin-transferrin receptor complex. J Struct Biol. 2005 Dec; 152(3):204-10.J Struct Biol2005-11-28T00:00:002005Single particle reconstruction of the human apo-transferrin-transferrin receptor complex.16809285Li F, Berardi M, Li W, Farzan M, Dormitzer PR, Harrison SCJournal of virologyConformational states of the severe acute respiratory syndrome coronavirus spike protein ectodomain. J Virol. 2006 Jul; 80(14):6794-800.J Virol2006-07-01T00:00:002006Conformational states of the severe acute respiratory syndrome coronavirus spike protein ectodomain.2398494Coombs KM, Fields BN, Harrison SCJournal of molecular biologyCrystallization of the reovirus type 3 Dearing core. Crystal packing is determined by the lambda 2 protein. J Mol Biol. 1990 Sep 05; 215(1):1-5.J Mol Biol1990-09-05T00:00:001990Crystallization of the reovirus type 3 Dearing core. Crystal packing is determined by the lambda 2 protein.19000820Lu X, McDonald SM, Tortorici MA, Tao YJ, Vasquez-Del Carpio R, Nibert ML, Patton JT, Harrison SCStructure (London, England : 1993)Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1. Structure. 2008 Nov 12; 16(11):1678-88.Structure2008-11-12T00:00:002008Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1.Authorship 1082546729999491Chao LH, Jang J, Johnson A, Nguyen A, Gray NS, Yang PL, Harrison SCeLifeHow small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion. Elife. 2018 07 12; 7.Elife2018-07-12T00:00:002018How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion.Authorship 113157417932686Hite RK, Gonen T, Harrison SC, Walz TPflugers Archiv : European journal of physiologyInteractions of lipids with aquaporin-0 and other membrane proteins. Pflugers Arch. 2008 Jul; 456(4):651-61.Pflugers Arch2007-10-12T00:00:002007Interactions of lipids with aquaporin-0 and other membrane proteins.18238898Zhang X, Settembre E, Xu C, Dormitzer PR, Bellamy R, Harrison SC, Grigorieff NProceedings of the National Academy of Sciences of the United States of AmericaNear-atomic resolution using electron cryomicroscopy and single-particle reconstruction. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):1867-72.Proc Natl Acad Sci U S A2008-01-31T00:00:002008Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction.18829437Floyd DL, Ragains JR, Skehel JJ, Harrison SC, van Oijen AMProceedings of the National Academy of Sciences of the United States of AmericaSingle-particle kinetics of influenza virus membrane fusion. Proc Natl Acad Sci U S A. 2008 Oct 07; 105(40):15382-7.Proc Natl Acad Sci U S A2008-09-30T00:00:002008Single-particle kinetics of influenza virus membrane fusion.22565972Haynes BF, Kelsoe G, Harrison SC, Kepler TBNature biotechnologyB-cell-lineage immunogen design in vaccine development with HIV-1 as a case study. Nat Biotechnol. 2012 May 07; 30(5):423-33.Nat Biotechnol2012-05-07T00:00:002012B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study.23236058Klein DE, Choi JL, Harrison SCJournal of virologyStructure of a dengue virus envelope protein late-stage fusion intermediate. J Virol. 2013 Feb; 87(4):2287-93.J Virol2012-12-12T00:00:002012Structure of a dengue virus envelope protein late-stage fusion intermediate.Authorship 1085950830055967Ferdman J, Palladino G, Liao HX, Moody MA, Kepler TB, Del Giudice G, Dormitzer PR, Harrison SC, Settembre EC, Suphaphiphat PVaccineIntra-seasonal antibody repertoire analysis of a subject immunized with an MF59®-adjuvanted pandemic 2009 H1N1 vaccine. Vaccine. 2018 08 23; 36(35):5325-5332.Vaccine2018-07-25T00:00:002018Intra-seasonal antibody repertoire analysis of a subject immunized with an MF59®-adjuvanted pandemic 2009 H1N1 vaccine.3805786Kirchhausen T, Harrison SC, Heuser JJournal of ultrastructure and molecular structure researchConfiguration of clathrin trimers: evidence from electron microscopy. J Ultrastruct Mol Struct Res. 1986 Mar; 94(3):199-208.J Ultrastruct Mol Struct Res1986-03-01T00:00:001986Configuration of clathrin trimers: evidence from electron microscopy.4033757Anderson JE, Ptashne M, Harrison SCNatureA phage repressor-operator complex at 7 A resolution. Nature. 1985 Aug 15-21; 316(6029):596-601.Nature1985-08-01T00:00:001985A phage repressor-operator complex at 7 A resolution.5281012Harrison SC, Caspar DL, Camerini-Otero RD, Franklin RMNature: New biologyLipid and protein arrangement in bacteriophage PM2. Nat New Biol. 1971 Feb 17; 229(7):197-201.Nat New Biol1971-02-17T00:00:001971Lipid and protein arrangement in bacteriophage PM2.834302Winkler FK, Schutt CE, Harrison SC, Bricogne GNatureTomato bushy stunt virus at 5.5-A resolution. Nature. 1977 Feb 10; 265(5594):509-13.Nature1977-02-10T00:00:001977Tomato bushy stunt virus at 5.5-A resolution.19439475Zhang L, Agosto MA, Ivanovic T, King DS, Nibert ML, Harrison SCJournal of virologyRequirements for the formation of membrane pores by the reovirus myristoylated micro1N peptide. J Virol. 2009 Jul; 83(14):7004-14.J Virol2009-05-13T00:00:002009Requirements for the formation of membrane pores by the reovirus myristoylated micro1N peptide.6417343Hogle J, Kirchhausen T, Harrison SCJournal of molecular biologyDivalent cation sites in tomato bushy stunt virus. Difference maps at 2-9 A resolution. J Mol Biol. 1983 Nov 25; 171(1):95-100.J Mol Biol1983-11-25T00:00:001983Divalent cation sites in tomato bushy stunt virus. Difference maps at 2-9 A resolution.7816143Glover JN, Harrison SCNatureCrystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. Nature. 1995 Jan 19; 373(6511):257-61.Nature1995-01-19T00:00:001995Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA.Authorship 11610918936246Harrison SCThe Journal of cell biologyThe pH sensor for flavivirus membrane fusion. J Cell Biol. 2008 Oct 20; 183(2):177-9.J Cell Biol2008-10-20T00:00:002008The pH sensor for flavivirus membrane fusion.2466201Harrison SCNaturePicornaviruses. Finding the receptors. Nature. 1989 Mar 16; 338(6212):205-6.Nature1989-03-16T00:00:001989Picornaviruses. Finding the receptors.20007281Trask SD, Kim IS, Harrison SC, Dormitzer PRJournal of virologyA rotavirus spike protein conformational intermediate binds lipid bilayers. J Virol. 2010 Feb; 84(4):1764-70.J Virol2009-12-09T00:00:002009A rotavirus spike protein conformational intermediate binds lipid bilayers.20122940McClain B, Settembre E, Temple BR, Bellamy AR, Harrison SCJournal of molecular biologyX-ray crystal structure of the rotavirus inner capsid particle at 3.8 A resolution. J Mol Biol. 2010 Mar 26; 397(2):587-99.J Mol Biol2010-02-01T00:00:002010X-ray crystal structure of the rotavirus inner capsid particle at 3.8 A resolution.Authorship 106186420947020Yu A, Xing Y, Harrison SC, Kirchhausen TStructure (London, England : 1993)Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling. Structure. 2010 Oct 13; 18(10):1311-20.Structure2010-10-13T00:00:002010Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling.3185709Wolberger C, Dong YC, Ptashne M, Harrison SCNatureStructure of a phage 434 Cro/DNA complex. Nature. 1988 Oct 27; 335(6193):789-95.Nature1988-10-27T00:00:001988Structure of a phage 434 Cro/DNA complex.3187531Aggarwal AK, Rodgers DW, Drottar M, Ptashne M, Harrison SCScience (New York, N.Y.)Recognition of a DNA operator by the repressor of phage 434: a view at high resolution. Science. 1988 Nov 11; 242(4880):899-907.Science1988-11-11T00:00:001988Recognition of a DNA operator by the repressor of phage 434: a view at high resolution.Authorship 1169334Authorship 1091569930185554Fu Q, Shaik MM, Cai Y, Ghantous F, Piai A, Peng H, Rits-Volloch S, Liu Z, Harrison SC, Seaman MS, Chen B, Chou JJProceedings of the National Academy of Sciences of the United States of AmericaStructure of the membrane proximal external region of HIV-1 envelope glycoprotein. 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Nature. 1995 Feb 09; 373(6514):536-9.Nature1995-02-09T00:00:001995Catalytic specificity of protein-tyrosine kinases is critical for selective signalling.7926781Ellenberger T, Fass D, Arnaud M, Harrison SCGenes & developmentCrystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer. Genes Dev. 1994 Apr 15; 8(8):970-80.Genes Dev1994-04-15T00:00:001994Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer.8266097Yan Y, Winograd E, Viel A, Cronin T, Harrison SC, Branton DScience (New York, N.Y.)Crystal structure of the repetitive segments of spectrin. 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Fingers and DNA half-turns.4508164Harrison SCCold Spring Harbor symposia on quantitative biologyStructure of tomato bushy stunt virus: three-dimensional x-ray diffraction analysis at 30 Angstrom resolution. Cold Spring Harb Symp Quant Biol. 1972; 36:495-501.Cold Spring Harb Symp Quant Biol1972-01-01T00:00:001972Structure of tomato bushy stunt virus: three-dimensional x-ray diffraction analysis at 30 Angstrom resolution.7248446Harrison SCBiophysical journalProtein interfaces and intersubunit bonding. The case of tomato bushy stunt virus. Biophys J. 1980 Oct; 32(1):139-53.Biophys J1980-10-01T00:00:001980Protein interfaces and intersubunit bonding. The case of tomato bushy stunt virus.1177319Jack A, Harrison SC, Crowther RAJournal of molecular biologyStructure of tomato bushy stunt virus. II. Comparison of results obtained by electron microscopy and x-ray diffraction. J Mol Biol. 1975 Sep 15; 97(2):163-72.J Mol Biol1975-09-15T00:00:001975Structure of tomato bushy stunt virus. II. 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Sci Rep. 2019 03 05; 9(1):3492.Sci Rep2019-03-05T00:00:002019Autoreactivity profiles of influenza hemagglutinin broadly neutralizing antibodies.D053586Phenomena2374990.720217Virus InternalizationD029701Chemicals & Drugs52618840.48734Saccharomyces cerevisiae ProteinsD036022Chemicals & Drugs1644790.753978Capsid ProteinsD018386Anatomy541940.856423KinetochoresAuthorship 1251955D012401Living Beings491090.895604RotavirusCell BiologyGeneticsMedicineNeurologyPediatricsMCB Board of TutorMolecular MedicineVaccine ResearchBeth Israel Deaconess Medical CenterBoston Children's HospitalDana-Farber Cancer InstituteFaculty of Arts & SciencesHarvard Medical SchoolImmune Disease InstituteMassachusetts General HospitalLHC4LukeChaoLuke H Chao, Ph.D.102275Chao, LukeAssistant Professor of GeneticsBC9BingChenBing Chen, Ph.D.42.33790000000000-71.1059000000000017396Chen, BingRosalind Franklin, PhD Professor of PediatricsJJL30JosephLoparoJoseph John Loparo, Ph.D.42.33738860000000-71.1043729000000036586Loparo, JosephProfessor of Biological Chemistry and Molecular PharmacologyAuthorship 115264417Authorship 1154988731092727Watanabe A, Su KY, Kuraoka M, Yang G, Reynolds AE, Schmidt AG, Harrison SC, Haynes BF, St Clair EW, Kelsoe GJCI insightSelf-tolerance curtails the B cell repertoire to microbial epitopes. 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Cell. 2019 05 16; 177(5):1124-1135.e16.Cell2019-05-16T00:00:002019Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism.11370selected publications8.143740.00115551814research areas5.79270.0087788161coauthor of293.636.361860similar toKS26KevinStruhlKevin Struhl, Ph.D.42.33588600000000-71.1051460000000013584Struhl, KevinDavid Wesley Gaiser Professor of Biological Chemistry and Molecular PharmacologyDMC2DonaldCoenDonald Mark Coen, Ph.D.42.33738860000000-71.1043729000000022117Coen, DonaldProfessor of Biological Chemistry and Molecular PharmacologySJ22SimonJenniSimon Jenni, Ph.D.42.33738860000000-71.1043729000000059820Jenni, SimonResearch Scientist in Biological Chemistry and Molecular PharmacologyAGS7AaronSchmidtAaron Gregory Schmidt, Ph.D.42.33588600000000-71.1051460000000064825Schmidt, AaronAssociate Professor of MicrobiologyJG128JohannaGutlernerJohanna Gutlerner, Ph.D.42.33738860000000-71.1043729000000034245Gutlerner, JohannaLecturer on Biological Chemistry and Molecular PharmacologyTK16TomasKirchhausenTomas Leopold Kirchhausen, Ph.D.42.33594500000000-71.1029580000000018590Kirchhausen, TomasProfessor of Cell BiologyDHB3DanBarouchDan Hung Barouch, M.D.42.34022770000000-71.1058540000000028268Barouch, DanWilliam Bosworth Castle Professor of MedicineDEG3DavidGolanDavid Eric Golan, M.D., Ph.D.42.33738860000000-71.1043729000000013800Golan, DavidProfessor of Biological Chemistry and Molecular PharmacologyGA25GalitAlterGalit Alter, Ph.D.42.37730000000000-71.0525000000000083846Alter, GalitProfessor of Medicine (on leave)JGS10JosephSodroskiJoseph Gerard Sodroski, M.D.42.33789600000000-71.1072493000000042351Sodroski, JosephProfessor of MicrobiologyAuthorship 1163525331194673Hinshaw SM, Dates AN, Harrison SCeLifeThe structure of the yeast Ctf3 complex. Elife. 2019 06 13; 8.Elife2019-06-13T00:00:002019The structure of the yeast Ctf3 complex.Authorship 1165394931233764Jenni S, Salgado EN, Herrmann T, Li Z, Grant T, Grigorieff N, Trapani S, Estrozi LF, Harrison SCJournal of molecular biologyIn situ Structure of Rotavirus VP1 RNA-Dependent RNA Polymerase. J Mol Biol. 2019 08 09; 431(17):3124-3138.J Mol Biol2019-06-21T00:00:002019In situ Structure of Rotavirus VP1 RNA-Dependent RNA Polymerase.Authorship 1180892431425683Lee PD, Wei H, Tan D, Harrison SCJournal of molecular biologyStructure of the Centromere Binding Factor 3 Complex from Kluyveromyces lactis. J Mol Biol. 2019 11 08; 431(22):4444-4454.J Mol Biol2019-08-17T00:00:002019Structure of the Centromere Binding Factor 3 Complex from Kluyveromyces lactis.Authorship 1167824true1Professor of MicrobiologyProfessor of MicrobiologyAuthorship 1210748531843892McCarthy KR, Raymond DD, Do KT, Schmidt AG, Harrison SCProceedings of the National Academy of Sciences of the United States of AmericaAffinity maturation in a human humoral response to influenza hemagglutinin. Proc Natl Acad Sci U S A. 2019 Dec 26; 116(52):26745-26751.Proc Natl Acad Sci U S A2019-12-16T00:00:002019Affinity maturation in a human humoral response to influenza hemagglutinin.Authorship 1217378731914397Jenni S, Bloyet LM, Diaz-Avalos R, Liang B, Whelan SPJ, Grigorieff N, Harrison SCCell reportsStructure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor. Cell Rep. 2020 01 07; 30(1):53-60.e5.Cell Rep2020-01-07T00:00:002020Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor.Authorship 12181973Authorship 1217875431931014Pan J, Peng H, Chen B, Harrison SCJournal of molecular biologyCryo-EM Structure of Full-length HIV-1 Env Bound With the Fab of Antibody PG16. J Mol Biol. 2020 02 14; 432(4):1158-1168.J Mol Biol2020-01-11T00:00:002020Cryo-EM Structure of Full-length HIV-1 Env Bound With the Fab of Antibody PG16.31953264Horwitz JA, Jenni S, Harrison SC, Whelan SPJProceedings of the National Academy of Sciences of the United States of AmericaStructure of a rabies virus polymerase complex from electron cryo-microscopy. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):2099-2107.Proc Natl Acad Sci U S A2020-01-17T00:00:002020Structure of a rabies virus polymerase complex from electron cryo-microscopy.Authorship 12213815Authorship 1221532231992870Mancia F, Harrison SCNature structural & molecular biologyThe human dimension in contemporary biological research. Nat Struct Mol Biol. 2020 02; 27(2):107-108.Nat Struct Mol Biol2020-02-01T00:00:002020The human dimension in contemporary biological research.32004465Migl D, Kschonsak M, Arthur CP, Khin Y, Harrison SC, Ciferri C, Dimitrova YNStructure (London, England : 1993)Cryoelectron Microscopy Structure of a Yeast Centromeric Nucleosome at 2.7 Å Resolution. Structure. 2020 03 03; 28(3):363-370.e3.Structure2020-01-30T00:00:002020Cryoelectron Microscopy Structure of a Yeast Centromeric Nucleosome at 2.7 Å Resolution.Authorship 1213137Authorship 1228573632108573Fei X, Bell TA, Jenni S, Stinson BM, Baker TA, Harrison SC, Sauer RTeLifeStructures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Elife. 2020 02 28; 9.Elife2020-02-28T00:00:002020Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate.Authorship 1233345232134386Hinshaw SM, Harrison SCeLifeCorrection: The structure of the Ctf19c/CCAN from budding yeast. Elife. 2020 Mar 05; 9.Elife2020-03-05T00:00:002020Correction: The structure of the Ctf19c/CCAN from budding yeast.Authorship 128743Authorship 1725141Authorship 187201Authorship 191516Authorship 2029814Authorship 125230017402335Harrison SCNatureVirus crystallography comes of age. Nature. 1980 Aug 07; 286(5773):558-9.Nature1980-08-07T00:00:001980Virus crystallography comes of age.Authorship 1256998532528179Tomasek D, Rawson S, Lee J, Wzorek JS, Harrison SC, Li Z, Kahne DNatureStructure of a nascent membrane protein as it folds on the BAM complex. Nature. 2020 07; 583(7816):473-478.Nature2020-06-11T00:00:002020Structure of a nascent membrane protein as it folds on the BAM complex.Authorship 1505003Authorship 1547406Authorship 1270336232679099Hinshaw SM, Harrison SCCurrent biology : CBThe Structural Basis for Kinetochore Stabilization by Cnn1/CENP-T. Curr Biol. 2020 09 07; 30(17):3425-3431.e3.Curr Biol2020-07-16T00:00:002020The Structural Basis for Kinetochore Stabilization by Cnn1/CENP-T.Authorship 1611383Authorship 1616783true1Assistant Professor of GeneticsAssistant Professor of Geneticstrue1David Wesley Gaiser Professor of Biological Chemistry and Molecular PharmacologyDavid Wesley Gaiser Professor of Biological Chemistry and Molecular Pharmacologytrue1Professor of Biological Chemistry and Molecular PharmacologyProfessor of Biological Chemistry and Molecular PharmacologyBCMPAuthorship 2065842Authorship 1885081Authorship 2090761Authorship 2294426Authorship 2297124Authorship 1364443Authorship 13031445433214287Roark RS, Li H, Williams WB, Chug H, Mason RD, Gorman J, Wang S, Lee FH, Rando J, Bonsignori M, Hwang KK, Saunders KO, Wiehe K, Moody MA, Hraber PT, Wagh K, Giorgi EE, Russell RM, Bibollet-Ruche F, Liu W, Connell J, Smith AG, DeVoto J, Murphy AI, Smith J, Ding W, Zhao C, Chohan N, Okumura M, Rosario C, Ding Y, Lindemuth E, Bauer AM, Bar KJ, Ambrozak D, Chao CW, Chuang GY, Geng H, Lin BC, Louder MK, Nguyen R, Zhang B, Lewis MG, Raymond DD, Doria-Rose NA, Schramm CA, Douek DC, Roederer M, Kepler TB, Kelsoe G, Mascola JR, Kwong PD, Korber BT, Harrison SC, Haynes BF, Hahn BH, Shaw GMScience (New York, N.Y.)Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth. Science. 2021 01 08; 371(6525).Science2020-11-19T00:00:002020Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.Authorship 1308804233274930Bajic G, Harrison SCACS infectious diseasesAntibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses. ACS Infect Dis. 2021 01 08; 7(1):1-5.ACS Infect Dis2020-12-04T00:00:002020Antibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses.Authorship 2153623Authorship 1546502Authorship 1319868833442061Herrmann T, Torres R, Salgado EN, Berciu C, Stoddard D, Nicastro D, Jenni S, Harrison SCNatureFunctional refolding of the penetration protein on a non-enveloped virus. Nature. 2021 02; 590(7847):666-670.Nature2021-01-13T00:00:002021Functional refolding of the penetration protein on a non-enveloped virus.Authorship 1332278433591274Zahm JA, Stewart MG, Carrier JS, Harrison SC, Miller MPeLifeStructural basis of Stu2 recruitment to yeast kinetochores. Elife. 2021 02 16; 10.Elife2021-02-16T00:00:002021Structural basis of Stu2 recruitment to yeast kinetochores.Authorship 2464461Authorship 13420882833758863Tong P, Gautam A, Windsor I, Travers M, Chen Y, Garcia N, Whiteman NB, McKay LGA, Lelis FJN, Habibi S, Cai Y, Rennick LJ, Duprex WP, McCarthy KR, Lavine CL, Zuo T, Lin J, Zuiani A, Feldman J, MacDonald EA, Hauser BM, Griffths A, Seaman MS, Schmidt AG, Chen B, Neuberg D, Bajic G, Harrison SC, Wesemann DRbioRxiv : the preprint server for biologyMemory B cell repertoire for recognition of evolving SARS-CoV-2 spike. bioRxiv. 2021 Mar 10.bioRxiv2021-03-10T00:00:002021Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike.Authorship 13602996Authorship 13610154Authorship 1361366834060327McCarthy KR, Lee J, Watanabe A, Kuraoka M, Robinson-McCarthy LR, Georgiou G, Kelsoe G, Harrison SCmBioA Prevalent Focused Human Antibody Response to the Influenza Virus Hemagglutinin Head Interface. mBio. 2021 06 29; 12(3):e0114421.mBio2021-06-01T00:00:002021A Prevalent Focused Human Antibody Response to the Influenza Virus Hemagglutinin Head Interface.34074774McCarthy KR, Von Holle TA, Sutherland LL, Oguin TH, Sempowski GD, Harrison SC, Moody MAProceedings of the National Academy of Sciences of the United States of AmericaDifferential immune imprinting by influenza virus vaccination and infection in nonhuman primates. Proc Natl Acad Sci U S A. 2021 06 08; 118(23).Proc Natl Acad Sci U S A2021-06-08T00:00:002021Differential immune imprinting by influenza virus vaccination and infection in nonhuman primates.34081091Quan Y, Hinshaw SM, Wang PC, Harrison SC, Zhou HThe Journal of cell biologyCtf3/CENP-I provides a docking site for the desumoylase Ulp2 at the kinetochore. J Cell Biol. 2021 08 02; 220(8).J Cell Biol2021-06-03T00:00:002021Ctf3/CENP-I provides a docking site for the desumoylase Ulp2 at the kinetochore.Authorship 2552962Authorship 13820473234332650Tong P, Gautam A, Windsor IW, Travers M, Chen Y, Garcia N, Whiteman NB, McKay LGA, Storm N, Malsick LE, Honko AN, Lelis FJN, Habibi S, Jenni S, Cai Y, Rennick LJ, Duprex WP, McCarthy KR, Lavine CL, Zuo T, Lin J, Zuiani A, Feldman J, MacDonald EA, Hauser BM, Griffths A, Seaman MS, Schmidt AG, Chen B, Neuberg D, Bajic G, Harrison SC, Wesemann DRCellMemory B cell repertoire for recognition of evolving SARS-CoV-2 spike. Cell. 2021 09 16; 184(19):4969-4980.e15.Cell2021-07-23T00:00:002021Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike.Authorship 1388726434437808MacDonald EA, Frey G, Namchuk MN, Harrison SC, Hinshaw SM, Windsor IWACS infectious diseasesRecognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease. ACS Infect Dis. 2021 09 10; 7(9):2591-2595.ACS Infect Dis2021-08-26T00:00:002021Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease.Authorship 1969353Authorship 2049946Authorship 2113942Authorship 2325835Authorship 2854253Authorship 1448560735522723Kuraoka M, Yeh CH, Bajic G, Kotaki R, Song S, Windsor I, Harrison SC, Kelsoe GScience immunologyRecall of B cell memory depends on relative locations of prime and boost immunization. Sci Immunol. 2022 05 06; 7(71):eabn5311.Sci Immunol2022-05-06T00:00:002022Recall of B cell memory depends on relative locations of prime and boost immunization.Authorship 3053282Authorship 14511151235536154Windsor IW, Tong P, Lavidor O, Moghaddam AS, McKay LGA, Gautam A, Chen Y, MacDonald EA, Yoo DK, Griffths A, Wesemann DR, Harrison SCScience immunologyAntibodies induced by an ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA.1. Sci Immunol. 2022 08 12; 7(74):eabo3425.Sci Immunol2022-08-12T00:00:002022Antibodies induced by an ancestral SARS-CoV-2 strain that cross-neutralize variants from Alpha to Omicron BA.1.Authorship 3275363Authorship 3413691Authorship 3544233Authorship 3869564Authorship 3894372Authorship 149380816Authorship 14930895Authorship 1480190936314798Kuraoka M, Curtis NC, Watanabe A, Tanno H, Shin S, Ye K, Macdonald E, Lavidor O, Kong S, Von Holle T, Windsor I, Ippolito GC, Georgiou G, Walter EB, Kelsoe G, Harrison SC, Moody MA, Bajic G, Lee JmBioInfant Antibody Repertoires during the First Two Years of Influenza Vaccination. mBio. 2022 12 20; 13(6):e0254622.mBio2022-10-31T00:00:002022Infant Antibody Repertoires during the First Two Years of Influenza Vaccination.35924923Jenni S, Li Z, Wang Y, Bessey T, Salgado EN, Schmidt AG, Greenberg HB, Jiang B, Harrison SCJournal of virologyRotavirus VP4 Epitope of a Broadly Neutralizing Human Antibody Defined by Its Structure Bound with an Attenuated-Strain Virion. J Virol. 2022 08 24; 96(16):e0062722.J Virol2022-08-04T00:00:002022Rotavirus VP4 Epitope of a Broadly Neutralizing Human Antibody Defined by Its Structure Bound with an Attenuated-Strain Virion.35970826Jenni S, Horwitz JA, Bloyet LM, Whelan SPJ, Harrison SCNature communicationsVisualizing molecular interactions that determine assembly of a bullet-shaped vesicular stomatitis virus particle. Nat Commun. 2022 08 15; 13(1):4802.Nat Commun2022-08-15T00:00:002022Visualizing molecular interactions that determine assembly of a bullet-shaped vesicular stomatitis virus particle.Authorship 4488593Authorship 4579791Authorship 4582736Authorship 21836710Authorship 2246194Authorship 2493513Authorship 24945611Authorship 1702052true1Research Scientist in Biological Chemistry and Molecular PharmacologyResearch Scientist in Biological Chemistry and Molecular PharmacologyAuthorship 1532137336883282Zahm JA, Jenni S, Harrison SCOpen biologyStructure of the Ndc80 complex and its interactions at the yeast kinetochore-microtubule interface. Open Biol. 2023 03; 13(3):220378.Open Biol2023-03-08T00:00:002023Structure of the Ndc80 complex and its interactions at the yeast kinetochore-microtubule interface.Authorship 1921063Authorship 1935836Authorship 1896084Authorship 4777994Authorship 4866846Authorship 4951124Authorship 2601916Ragon Institute of MGH, MIT and HarvardAuthorship 2838592Authorship 3048183Authorship 3539671true1Research Fellow in NeurologyResearch Fellow in Neurologytrue1Professor of Biological Chemistry and Molecular PharmacologyProfessor of Biological Chemistry and Molecular Pharmacologytrue1William Bosworth Castle Professor of MedicineWilliam Bosworth Castle Professor of Medicinetrue1Associate Professor of MicrobiologyAssociate Professor of MicrobiologyRagon Institute of MGH, MIT and HarvardAuthorship 4458598Authorship 1598875437905109De Sautu M, Herrmann T, Jenni S, Harrison SCbioRxiv : the preprint server for biologyThe rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2. bioRxiv. 2023 Oct 16.bioRxiv2023-10-16T00:00:002023The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2.Authorship 180273237983946Deng S, Cai J, Harrison SC, Zhou H, Hinshaw SMEMBO reportsRecognition of centromere-specific histone Cse4 by the inner kinetochore Okp1-Ame1 complex. EMBO Rep. 2023 Dec 06; 24(12):e57702.EMBO Rep2023-11-20T00:00:002023Recognition of centromere-specific histone Cse4 by the inner kinetochore Okp1-Ame1 complex.Authorship 4833481Authorship 4841503Authorship 16078913Authorship 16168471638147556Finney J, Moseman AP, Kong S, Watanabe A, Song S, Walsh RM, Kuraoka M, Kotaki R, Moseman EA, McCarthy KR, Liao D, Liang X, Nie X, Lavidor O, Abbott R, Harrison SC, Kelsoe GProceedings of the National Academy of Sciences of the United States of AmericaProtective human antibodies against a conserved epitope in pre- and postfusion influenza hemagglutinin. Proc Natl Acad Sci U S A. 2024 Jan 02; 121(1):e2316964120.Proc Natl Acad Sci U S A2023-12-26T00:00:002023Protective human antibodies against a conserved epitope in pre- and postfusion influenza hemagglutinin.Authorship 5600032true1Professor of Biological Chemistry and Molecular PharmacologyProfessor of Biological Chemistry and Molecular Pharmacologytrue1Lecturer on Biological Chemistry and Molecular PharmacologyLecturer on Biological Chemistry and Molecular Pharmacologytrue1Professor of Cell BiologyProfessor of Cell Biologytrue1Professor of Medicine (on leave)Professor of Medicine (on leave)3Tutor, Academic (Other Faculty)Tutor, Academic (Other Faculty)true1Rosalind Franklin, PhD Professor of PediatricsRosalind Franklin, PhD Professor of Pediatrics2Professor of PediatricsProfessor of Pediatricstrue1Giovanni Armenise - Harvard Professor of Basic Biomedical ScienceGiovanni Armenise - Harvard Professor of Basic Biomedical ScienceAuthorship 5494562Authorship 4537813Authorship 2422768Authorship 2552553Authorship 2573601Authorship 3165954Authorship 63381631056756Cohen C, DeRosier D, Harrison SC, Stephens RE, Thomas JAnnals of the New York Academy of SciencesX-ray patterns from microtubules. Ann N Y Acad Sci. 1975 Jun 30; 253:53-9.Ann N Y Acad Sci1975-06-30T00:00:001975X-ray patterns from microtubules.Authorship 648284Authorship 775952Authorship 979211Authorship 580762Authorship 2135803Authorship 2160702Authorship 6810136Authorship 681638223904294Patel SD, Ahouidi AD, Bei AK, Dieye TN, Mboup S, Harrison SC, Duraisingh MTThe Journal of infectious diseasesPlasmodium falciparum merozoite surface antigen, PfRH5, elicits detectable levels of invasion-inhibiting antibodies in humans. J Infect Dis. 2013 Nov 15; 208(10):1679-87.J Infect Dis2013-07-31T00:00:002013Plasmodium falciparum merozoite surface antigen, PfRH5, elicits detectable levels of invasion-inhibiting antibodies in humans.24075991Hinshaw SM, Harrison SCCell reportsAn Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation. Cell Rep. 2013 Oct 17; 5(1):29-36.Cell Rep2013-09-26T00:00:002013An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation.Authorship 2544961Authorship 2780803Authorship 6891692123580138Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KH, Copenhaver GP, Deluca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LE, Karpen G, Kops GJ, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O'Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K, Cleveland DWChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biologyEsperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res. 2013 Apr; 21(2):101-6.Chromosome Res2013-04-12T00:00:002013Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.Authorship 3289214Authorship 3335302Authorship 691948624017405Baker TS, Zhang X, Tang J, Ji Y, Zhang L, Harrison SC, Marinescu DC, Nibert MLMicroscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of CanadaDissecting the Structure and Function of the Orthoreovirus µ1 ('Penetrini') Protein at 7.0-Å and Higher Resolution. Microsc Microanal. 2005 Aug; 11 Suppl 2:1070-1.Microsc Microanal2005-08-01T00:00:002005Dissecting the Structure and Function of the Orthoreovirus µ1 ('Penetrini') Protein at 7.0-Å and Higher Resolution.Authorship 3691033Authorship 1983923Authorship 2346413Authorship 4055362Authorship 1739452Authorship 2626522Authorship 2706755Authorship 3016631Authorship 42016511Authorship 4507355Authorship 2785714Authorship 2873836Authorship 2641491Authorship 3036272Authorship 727547324789820Kirchhausen T, Owen D, Harrison SCCold Spring Harbor perspectives in biologyMolecular structure, function, and dynamics of clathrin-mediated membrane traffic. Cold Spring Harb Perspect Biol. 2014 May 01; 6(5):a016725.Cold Spring Harb Perspect Biol2014-05-01T00:00:002014Molecular structure, function, and dynamics of clathrin-mediated membrane traffic.Authorship 1830696Authorship 2345889Authorship 2406015Authorship 2612505Authorship 2013734Authorship 3304043Authorship 743420724982157Fera D, Schmidt AG, Haynes BF, Gao F, Liao HX, Kepler TB, Harrison SCProceedings of the National Academy of Sciences of the United States of AmericaAffinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10275-80.Proc Natl Acad Sci U S A2014-06-30T00:00:002014Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains.Authorship 3089243Authorship 4502924Authorship 4506981Authorship 3645712Authorship 5167286Authorship 5313431Authorship 756480725211455Abdelhakim AH, Salgado EN, Fu X, Pasham M, Nicastro D, Kirchhausen T, Harrison SCPLoS pathogensStructural correlates of rotavirus cell entry. PLoS Pathog. 2014 Sep; 10(9):e1004355.PLoS Pathog2014-09-11T00:00:002014Structural correlates of rotavirus cell entry.Authorship 3539205Authorship 3675102Authorship 3777824Authorship 3858284Authorship 4115943Authorship 4849172Authorship 4794964Authorship 778593625512514Kovacs JM, Noeldeke E, Ha HJ, Peng H, Rits-Volloch S, Harrison SC, Chen BProceedings of the National Academy of Sciences of the United States of AmericaStable, uncleaved HIV-1 envelope glycoprotein gp140 forms a tightly folded trimer with a native-like structure. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18542-7.Proc Natl Acad Sci U S A2014-12-15T00:00:002014Stable, uncleaved HIV-1 envelope glycoprotein gp140 forms a tightly folded trimer with a native-like structure.Authorship 5691354Authorship 543945225479384Chao LH, Klein DE, Schmidt AG, Peña JM, Harrison SCeLifeSequential conformational rearrangements in flavivirus membrane fusion. Elife. 2014 Dec 05; 3:e04389.Elife2014-12-05T00:00:002014Sequential conformational rearrangements in flavivirus membrane fusion.25524709Xu H, Schmidt AG, O'Donnell T, Therkelsen MD, Kepler TB, Moody MA, Haynes BF, Liao HX, Harrison SC, Shaw DEProteinsKey mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage. Proteins. 2015 Apr; 83(4):771-80.Proteins2015-02-28T00:00:002015Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage.Authorship 596301Authorship 689355Authorship 969492Authorship 399493Authorship 4079804Authorship 5503904Authorship 967154Authorship 3886012Authorship 3906436Authorship 3907244Authorship 4125403Authorship 4175904Authorship 42871913Authorship 4302313Authorship 202273Authorship 1701383Authorship 2285249Authorship 4505756Authorship 4525744Authorship 304031Authorship 5066792Authorship 5164353Authorship 4700462Authorship 4982855Authorship 5181952Authorship 5190673Authorship 4865367Authorship 2110312Authorship 4906022Authorship 5446515Authorship 610463Authorship 5117934Authorship 2134343Authorship 635857Authorship 4170777Authorship 694614Authorship 4225644Authorship 17055819Authorship 2917982Authorship 4956622Authorship 5154533Authorship 5515741Authorship 5755347Authorship 2561242Authorship 1860626Authorship 2149403Authorship 91375Authorship 852203Authorship 2646745Authorship 3039644Authorship 3593941Authorship 2438941Authorship 4139731Authorship 2104363Authorship 276079Authorship 3077666Authorship 3158244Authorship 3247991Authorship 20348331Authorship 25387222Authorship 2193573Authorship 2555584Authorship 2932231Authorship 318318525959776Schmidt AG, Therkelsen MD, Stewart S, Kepler TB, Liao HX, Moody MA, Haynes BF, Harrison SCCellViral receptor-binding site antibodies with diverse germline origins. Cell. 2015 May 21; 161(5):1026-1034.Cell2015-05-07T00:00:002015Viral receptor-binding site antibodies with diverse germline origins.Authorship 408715101Authorship 5165075Authorship 3820912Authorship 2363663Authorship 2802621Authorship 766451Authorship 3045921Authorship 2226321Authorship 4489455Authorship 2336864Authorship 3667243Authorship 3695923Authorship 4698371Authorship 5016132Authorship 51616010Authorship 5186581Authorship 1589394Authorship 1674602Authorship 4123131Authorship 3517305Authorship 3695704Authorship 3749363Authorship 3948791Authorship 4144042Authorship 4659021Authorship 4692946Authorship 535274Authorship 7931375Authorship 8073419Authorship 7915261Authorship 7999256Authorship 7911318Authorship 797030525494302Harrison SCAnnual review of biochemistryVeritas per structuram. Annu Rev Biochem. 2015; 84:37-60.Annu Rev Biochem2014-12-08T00:00:002014Veritas per structuram.25984968Chao LH, Klein DE, Schmidt AG, Peña JM, Harrison SCeLifeCorrection: Sequential conformational rearrangements in flavivirus membrane fusion. Elife. 2015 May 18; 4.Elife2015-05-18T00:00:002015Correction: Sequential conformational rearrangements in flavivirus membrane fusion.25699547Wang Q, Vogan EM, Nocka LM, Rosen CE, Zorn JA, Harrison SC, Kuriyan JeLifeAutoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Elife. 2015 Feb 20; 4.Elife2015-02-20T00:00:002015Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate.Authorship 2922774Authorship 3394641Authorship 1721285Authorship 2715654Authorship 2762753Authorship 2982192Authorship 3381216Authorship 3716466Authorship 3753111Authorship 3768058Authorship 4554434Authorship 4559179Authorship 4794174Authorship 5346616Authorship 3714148Authorship 3799052Authorship 3860403Authorship 4256593Authorship 4452562Authorship 4475122Authorship 4705565Authorship 8133471Authorship 809591526038942Hinshaw SM, Makrantoni V, Kerr A, Marston AL, Harrison SCeLifeStructural evidence for Scc4-dependent localization of cohesin loading. Elife. 2015 Jun 03; 4:e06057.Elife2015-06-03T00:00:002015Structural evidence for Scc4-dependent localization of cohesin loading.25866377Harrison SCVirologyViral membrane fusion. Virology. 2015 May; 479-480:498-507.Virology2015-04-10T00:00:002015Viral membrane fusion.Authorship 2913503Authorship 3151413Authorship 3295391Authorship 3307033Authorship 816761826144317Liang B, Li Z, Jenni S, Rahmeh AA, Morin BM, Grant T, Grigorieff N, Harrison SC, Whelan SPJCellStructure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy. Cell. 2015 Jul 16; 162(2):314-327.Cell2015-07-02T00:00:002015Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy.Authorship 3428353Authorship 3693023Authorship 374202Authorship 3916775Authorship 5239522Authorship 5729106Authorship 393891526651946Mahmutovic S, Clark L, Levis SC, Briggiler AM, Enria DA, Harrison SC, Abraham JCell host & microbeMolecular Basis for Antibody-Mediated Neutralization of New World Hemorrhagic Fever Mammarenaviruses. Cell Host Microbe. 2015 Dec 09; 18(6):705-13.Cell Host Microbe2015-12-09T00:00:002015Molecular Basis for Antibody-Mediated Neutralization of New World Hemorrhagic Fever Mammarenaviruses.Authorship 4247724Authorship 8529006Authorship 438031726711348Schmidt AG, Do KT, McCarthy KR, Kepler TB, Liao HX, Moody MA, Haynes BF, Harrison SCCell reportsImmunogenic Stimulus for Germline Precursors of Antibodies that Engage the Influenza Hemagglutinin Receptor-Binding Site. Cell Rep. 2015 Dec 29; 13(12):2842-50.Cell Rep2015-12-17T00:00:002015Immunogenic Stimulus for Germline Precursors of Antibodies that Engage the Influenza Hemagglutinin Receptor-Binding Site.Authorship 450255Authorship 8560798Authorship 500715Authorship 50646451999-08-27T00:00:001999-05-21T00:00:00Design of Inhibitors to Prevent gp-41 Mediated HIV-1 Membrane FusionSummerAuthorship 8577512726725118Bradley T, Fera D, Bhiman J, Eslamizar L, Lu X, Anasti K, Zhang R, Sutherland LL, Scearce RM, Bowman CM, Stolarchuk C, Lloyd KE, Parks R, Eaton A, Foulger A, Nie X, Karim SSA, Barnett S, Kelsoe G, Kepler TB, Alam SM, Montefiori DC, Moody MA, Liao HX, Morris L, Santra S, Harrison SC, Haynes BFCell reportsStructural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site. Cell Rep. 2016 Jan 05; 14(1):43-54.Cell Rep2015-12-24T00:00:002015Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.Authorship 86819436Authorship 864066226613408Ivanovic T, Harrison SCeLifeDistinct functional determinants of influenza hemagglutinin-mediated membrane fusion. Elife. 2015 Nov 27; 4:e11009.Elife2015-11-27T00:00:002015Distinct functional determinants of influenza hemagglutinin-mediated membrane fusion.26947396Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz PNature communicationsData publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 07; 7:10882.Nat Commun2016-03-07T00:00:002016Data publication with the structural biology data grid supports live analysis.Authorship 979714Authorship 964332Authorship 872147726948373Kuraoka M, Schmidt AG, Nojima T, Feng F, Watanabe A, Kitamura D, Harrison SC, Kepler TB, Kelsoe GImmunityComplex Antigens Drive Permissive Clonal Selection in Germinal Centers. Immunity. 2016 Mar 15; 44(3):542-552.Immunity2016-03-03T00:00:002016Complex Antigens Drive Permissive Clonal Selection in Germinal Centers.Authorship 3393176Authorship 5205214Authorship 757636Authorship 9104552Assistant Professor1Associate Professor6Fellow or Post Doc0Full Professor3Lecturer5Other FacultyAuthorship 682333Authorship 846333Authorship 5586356Authorship 5660669Authorship 5741061Authorship 651242Authorship 5018852Authorship 908114127540984Harrison SCNature immunologyImmunogenic cross-talk between dengue and Zika viruses. 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Cell Rep. 2016 10 11; 17(3):929.Cell Rep2016-10-11T00:00:002016Molecular Architecture of the Yeast Monopolin Complex.Authorship 4692953Authorship 5586415Authorship 5630871Authorship 574345Authorship 93105721Authorship 931503327820604Raymond DD, Stewart SM, Lee J, Ferdman J, Bajic G, Do KT, Ernandes MJ, Suphaphiphat P, Settembre EC, Dormitzer PR, Del Giudice G, Finco O, Kang TH, Ippolito GC, Georgiou G, Kepler TB, Haynes BF, Moody MA, Liao HX, Schmidt AG, Harrison SCNature medicineInfluenza immunization elicits antibodies specific for an egg-adapted vaccine strain. Nat Med. 2016 12; 22(12):1465-1469.Nat Med2016-11-07T00:00:002016Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain.27851957Valverde R, Ingram J, Harrison SCCell reportsConserved Tetramer Junction in the Kinetochore Ndc80 Complex. Cell Rep. 2016 11 15; 17(8):1915-1922.Cell Rep2016-11-15T00:00:002016Conserved Tetramer Junction in the Kinetochore Ndc80 Complex.Authorship 93812513Authorship 937941527881300Dimitrova YN, Jenni S, Valverde R, Khin Y, Harrison SCCellStructure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly. Cell. 2016 11 03; 167(4):1014-1027.e12.Cell2016-10-27T00:00:002016Structure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly.27881301Petrovic A, Keller J, Liu Y, Overlack K, John J, Dimitrova YN, Jenni S, van Gerwen S, Stege P, Wohlgemuth S, Rombaut P, Herzog F, Harrison SC, Vetter IR, Musacchio ACellStructure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores. Cell. 2016 11 03; 167(4):1028-1040.e15.Cell2016-10-27T00:00:002016Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores.Authorship 2291143Authorship 2327392Authorship 2858255Authorship 3651363Authorship 4180344Authorship 4182644Authorship 947094727974607Kim IS, Jenni S, Stanifer ML, Roth E, Whelan SP, van Oijen AM, Harrison SCProceedings of the National Academy of Sciences of the United States of AmericaMechanism of membrane fusion induced by vesicular stomatitis virus G protein. Proc Natl Acad Sci U S A. 2017 01 03; 114(1):E28-E36.Proc Natl Acad Sci U S A2016-12-14T00:00:002016Mechanism of membrane fusion induced by vesicular stomatitis virus G protein.Authorship 479132Authorship 5447263Authorship 55700348756715Harrison SCCellPeptide-surface association: the case of PDZ and PTB domains. Cell. 1996 Aug 09; 86(3):341-3.Cell1996-08-09T00:00:001996Peptide-surface association: the case of PDZ and PTB domains.8805524Stehle T, Harrison SCStructure (London, England : 1993)Crystal structures of murine polyomavirus in complex with straight-chain and branched-chain sialyloligosaccharide receptor fragments. Structure. 1996 Feb 15; 4(2):183-94.Structure1996-02-15T00:00:001996Crystal structures of murine polyomavirus in complex with straight-chain and branched-chain sialyloligosaccharide receptor fragments.8805522Yan Y, Stehle T, Liddington RC, Zhao H, Harrison SCStructure (London, England : 1993)Structure determination of simian virus 40 and murine polyomavirus by a combination of 30-fold and 5-fold electron-density averaging. Structure. 1996 Feb 15; 4(2):157-64.Structure1996-02-15T00:00:001996Structure determination of simian virus 40 and murine polyomavirus by a combination of 30-fold and 5-fold electron-density averaging.8962058Musacchio A, Cantley LC, Harrison SCProceedings of the National Academy of Sciences of the United States of AmericaCrystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14373-8.Proc Natl Acad Sci U S A1996-12-10T00:00:001996Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit.9668045Huse M, Eck MJ, Harrison SCThe Journal of biological chemistryA Zn2+ ion links the cytoplasmic tail of CD4 and the N-terminal region of Lck. 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Nature. 2004 Dec 02; 432(7017):573-9.Nature2004-10-24T00:00:002004Molecular model for a complete clathrin lattice from electron cryomicroscopy.Authorship 9666135Authorship 9689173128235027Easterhoff D, Moody MA, Fera D, Cheng H, Ackerman M, Wiehe K, Saunders KO, Pollara J, Vandergrift N, Parks R, Kim J, Michael NL, O'Connell RJ, Excler JL, Robb ML, Vasan S, Rerks-Ngarm S, Kaewkungwal J, Pitisuttithum P, Nitayaphan S, Sinangil F, Tartaglia J, Phogat S, Kepler TB, Alam SM, Liao HX, Ferrari G, Seaman MS, Montefiori DC, Tomaras GD, Harrison SC, Haynes BFPLoS pathogensBoosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial. 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Structure. 2007 Mar; 15(3):355-62.Structure2007-03-01T00:00:002007Crystal structure of a TOG domain: conserved features of XMAP215/Dis1-family TOG domains and implications for tubulin binding.28396421Cai Y, Karaca-Griffin S, Chen J, Tian S, Fredette N, Linton CE, Rits-Volloch S, Lu J, Wagh K, Theiler J, Korber B, Seaman MS, Harrison SC, Carfi A, Chen BProceedings of the National Academy of Sciences of the United States of AmericaAntigenicity-defined conformations of an extremely neutralization-resistant HIV-1 envelope spike. Proc Natl Acad Sci U S A. 2017 04 25; 114(17):4477-4482.Proc Natl Acad Sci U S A2017-04-10T00:00:002017Antigenicity-defined conformations of an extremely neutralization-resistant HIV-1 envelope spike.10394364Musacchio A, Smith CJ, Roseman AM, Harrison SC, Kirchhausen T, Pearse BMMolecular cellFunctional organization of clathrin in coats: combining electron cryomicroscopy and X-ray crystallography. 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Nature. 1998 Mar 05; 392(6671):42-8.Nature1998-03-05T00:00:001998Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA.Authorship 983483828506635Liu Y, Pan J, Jenni S, Raymond DD, Caradonna T, Do KT, Schmidt AG, Harrison SC, Grigorieff NJournal of molecular biologyCryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface. J Mol Biol. 2017 06 16; 429(12):1829-1839.J Mol Biol2017-05-12T00:00:002017CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface.10801118Reinisch KM, Nibert ML, Harrison SCNatureStructure of the reovirus core at 3.6 A resolution. Nature. 2000 Apr 27; 404(6781):960-7.Nature2000-04-27T00:00:002000Structure of the reovirus core at 3.6 A resolution.19520960Aoki ST, Settembre EC, Trask SD, Greenberg HB, Harrison SC, Dormitzer PRScience (New York, N.Y.)Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab. 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Nature. 1991 Oct 24; 353(6346):715-9.Nature1991-10-24T00:00:001991A structural taxonomy of DNA-binding domains.15329727Dormitzer PR, Nason EB, Prasad BV, Harrison SCNatureStructural rearrangements in the membrane penetration protein of a non-enveloped virus. Nature. 2004 Aug 26; 430(7003):1053-8.Nature2004-08-26T00:00:002004Structural rearrangements in the membrane penetration protein of a non-enveloped virus.1339691Harrison SC, Wang J, Yan Y, Garrett T, Liu J, Moebius U, Reinherz ECold Spring Harbor symposia on quantitative biologyStructure and interactions of CD4. Cold Spring Harb Symp Quant Biol. 1992; 57:541-8.Cold Spring Harb Symp Quant Biol1992-01-01T00:00:001992Structure and interactions of CD4.15809444Wei RR, Sorger PK, Harrison SCProceedings of the National Academy of Sciences of the United States of AmericaMolecular organization of the Ndc80 complex, an essential kinetochore component. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5363-7.Proc Natl Acad Sci U S A2005-04-04T00:00:002005Molecular organization of the Ndc80 complex, an essential kinetochore component.16765893Wei RR, Schnell JR, Larsen NA, Sorger PK, Chou JJ, Harrison SCStructure (London, England : 1993)Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. Structure. 2006 Jun; 14(6):1003-9.Structure2006-06-01T00:00:002006Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain.Authorship 985330128559165Harrison SCJournal of structural biologyProtein tentacles. J Struct Biol. 2017 12; 200(3):244-247.J Struct Biol2017-05-27T00:00:002017Protein tentacles.9153399Casasnovas JM, Springer TA, Liu JH, Harrison SC, Wang JHNatureCrystal structure of ICAM-2 reveals a distinctive integrin recognition surface. Nature. 1997 May 15; 387(6630):312-5.Nature1997-05-15T00:00:001997Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface.17195848Wei RR, Al-Bassam J, Harrison SCNature structural & molecular biologyThe Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment. Nat Struct Mol Biol. 2007 Jan; 14(1):54-9.Nat Struct Mol Biol2006-12-31T00:00:002006The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment.18059448Harrison SCNature structural & molecular biologyThree-dimensional intricacies in protein-DNA recognition and transcriptional control. Nat Struct Mol Biol. 2007 Dec; 14(12):1118-9.Nat Struct Mol Biol2007-12-01T00:00:002007Three-dimensional intricacies in protein-DNA recognition and transcriptional control.14661030Van den Berg B, Clemons WM, Collinson I, Modis Y, Hartmann E, Harrison SC, Rapoport TANatureX-ray structure of a protein-conducting channel. Nature. 2004 Jan 01; 427(6969):36-44.Nature2003-12-03T00:00:002003X-ray structure of a protein-conducting channel.9094337DeRosier DJ, Harrison SCCurrent opinion in structural biologyMacromolecular assemblages. Sizing things up. Curr Opin Struct Biol. 1997 Apr; 7(2):237-8.Curr Opin Struct Biol1997-04-01T00:00:001997Macromolecular assemblages. Sizing things up.9653108Berger JM, Fass D, Wang JC, Harrison SCProceedings of the National Academy of Sciences of the United States of AmericaStructural similarities between topoisomerases that cleave one or both DNA strands. Proc Natl Acad Sci U S A. 1998 Jul 07; 95(14):7876-81.Proc Natl Acad Sci U S A1998-07-07T00:00:001998Structural similarities between topoisomerases that cleave one or both DNA strands.12759475Modis Y, Ogata S, Clements D, Harrison SCProceedings of the National Academy of Sciences of the United States of AmericaA ligand-binding pocket in the dengue virus envelope glycoprotein. 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Nature. 2010 Aug 26; 466(7310):1048-9.Nature2010-08-26T00:00:002010Structural biology: Conservation in vesicle coats.3387430Koudelka GB, Harbury P, Harrison SC, Ptashne MProceedings of the National Academy of Sciences of the United States of AmericaDNA twisting and the affinity of bacteriophage 434 operator for bacteriophage 434 repressor. Proc Natl Acad Sci U S A. 1988 Jul; 85(13):4633-7.Proc Natl Acad Sci U S A1988-07-01T00:00:001988DNA twisting and the affinity of bacteriophage 434 operator for bacteriophage 434 repressor.3681985Wolberger C, Harrison SCJournal of molecular biologyCrystallization and X-ray diffraction studies of a 434 Cro-DNA complex. J Mol Biol. 1987 Aug 20; 196(4):951-4.J Mol Biol1987-08-20T00:00:001987Crystallization and X-ray diffraction studies of a 434 Cro-DNA complex.3806677Sorger PK, Stockley PG, Harrison SCJournal of molecular biologyStructure and assembly of turnip crinkle virus. II. Mechanism of reassembly in vitro. J Mol Biol. 1986 Oct 20; 191(4):639-58.J Mol Biol1986-10-20T00:00:001986Structure and assembly of turnip crinkle virus. II. Mechanism of reassembly in vitro.3553960Koudelka GB, Harrison SC, Ptashne MNatureEffect of non-contacted bases on the affinity of 434 operator for 434 repressor and Cro. Nature. 1987 Apr 30-May 6; 326(6116):886-8.Nature1987-04-01T00:00:001987Effect of non-contacted bases on the affinity of 434 operator for 434 repressor and Cro.3563513Kirchhausen T, Scarmato P, Harrison SC, Monroe JJ, Chow EP, Mattaliano RJ, Ramachandran KL, Smart JE, Ahn AH, Brosius JScience (New York, N.Y.)Clathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs. Science. 1987 Apr 17; 236(4799):320-4.Science1987-04-17T00:00:001987Clathrin light chains LCA and LCB are similar, polymorphic, and share repeated heptad motifs.3704639Durbin RM, Burns R, Moulai J, Metcalf P, Freymann D, Blum M, Anderson JE, Harrison SC, Wiley DCScience (New York, N.Y.)Protein, DNA, and virus crystallography with a focused imaging proportional counter. Science. 1986 May 30; 232(4754):1127-32.Science1986-05-30T00:00:001986Protein, DNA, and virus crystallography with a focused imaging proportional counter.Authorship 994225328701394Salgado EN, Upadhyayula S, Harrison SCJournal of virologySingle-Particle Detection of Transcription following Rotavirus Entry. J Virol. 2017 Sep 15; 91(18).J Virol2017-08-24T00:00:002017Single-Particle Detection of Transcription following Rotavirus Entry.6140290Schmaljohn CS, Hasty SE, Harrison SA, Dalrymple JMThe Journal of infectious diseasesCharacterization of Hantaan virions, the prototype virus of hemorrhagic fever with renal syndrome. J Infect Dis. 1983 Dec; 148(6):1005-12.J Infect Dis1983-12-01T00:00:001983Characterization of Hantaan virions, the prototype virus of hemorrhagic fever with renal syndrome.4105308Cohen C, Harrison SC, Stephens REJournal of molecular biologyX-ray diffraction from microtubules. J Mol Biol. 1971 Jul 28; 59(2):375-80.J Mol Biol1971-07-28T00:00:001971X-ray diffraction from microtubules.6135512Harrison SC, Kirchhausen TCellClathrin, cages, and coated vesicles. Cell. 1983 Jul; 33(3):650-2.Cell1983-07-01T00:00:001983Clathrin, cages, and coated vesicles.18191222Brouhard GJ, Stear JH, Noetzel TL, Al-Bassam J, Kinoshita K, Harrison SC, Howard J, Hyman AACellXMAP215 is a processive microtubule polymerase. Cell. 2008 Jan 11; 132(1):79-88.Cell2008-01-11T00:00:002008XMAP215 is a processive microtubule polymerase.19711552Harrison SC, Olson AJ, Schutt CE, Winkler FK, Bricogne GNatureTomato bushy stunt virus at 2.9 A resolution. Nature. 1978 Nov 23; 276(5686):368-73.Nature1978-11-23T00:00:001978Tomato bushy stunt virus at 2.9 A resolution.19736545Floyd DL, Harrison SC, van Oijen AMJournal of visualized experiments : JoVEMethod for measurement of viral fusion kinetics at the single particle level. J Vis Exp. 2009 Sep 07; (31).J Vis Exp2009-09-07T00:00:002009Method for measurement of viral fusion kinetics at the single particle level.6362365Harrison SCAdvances in virus researchVirus structure: high-resolution perspectives. Adv Virus Res. 1983; 28:175-240.Adv Virus Res1983-01-01T00:00:001983Virus structure: high-resolution perspectives.7330049Harrison SCProgress in clinical and biological researchMolecular organization of virus particles: implications for assembly. Prog Clin Biol Res. 1981; 64:3-18.Prog Clin Biol Res1981-01-01T00:00:001981Molecular organization of virus particles: implications for assembly.8094247Harrison SCProceedings of the National Academy of Sciences of the United States of AmericaCommon cold virus and its receptor. Proc Natl Acad Sci U S A. 1993 Feb 01; 90(3):783.Proc Natl Acad Sci U S A1993-02-01T00:00:001993Common cold virus and its receptor.8605622Müller CW, Rey FA, Harrison SCNature structural biologyComparison of two different DNA-binding modes of the NF-kappa B p50 homodimer. Nat Struct Biol. 1996 Mar; 3(3):224-7.Nat Struct Biol1996-03-01T00:00:001996Comparison of two different DNA-binding modes of the NF-kappa B p50 homodimer.2023243Borhani DW, Harrison SCJournal of molecular biologyCrystallization and X-ray diffraction studies of a soluble form of the human transferrin receptor. J Mol Biol. 1991 Apr 20; 218(4):685-9.J Mol Biol1991-04-20T00:00:001991Crystallization and X-ray diffraction studies of a soluble form of the human transferrin receptor.2038059Mondragón A, Harrison SCJournal of molecular biologyThe phage 434 Cro/OR1 complex at 2.5 A resolution. J Mol Biol. 1991 May 20; 219(2):321-34.J Mol Biol1991-05-20T00:00:001991The phage 434 Cro/OR1 complex at 2.5 A resolution.21849465Aoki ST, Trask SD, Coulson BS, Greenberg HB, Dormitzer PR, Harrison SCJournal of virologyCross-linking of rotavirus outer capsid protein VP7 by antibodies or disulfides inhibits viral entry. 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J Mol Biol. 1990 Aug 05; 214(3):627-32.J Mol Biol1990-08-05T00:00:001990Calcium binding sites in tomato bushy stunt virus visualized by Laue crystallography.2854217Rapundalo ST, Lathrop DA, Harrison SA, Beavo JA, Schwartz ANaunyn-Schmiedeberg's archives of pharmacologyCyclic AMP-dependent and cyclic AMP-independent actions of a novel cardiotonic agent, OPC-8212. Naunyn Schmiedebergs Arch Pharmacol. 1988 Dec; 338(6):692-8.Naunyn Schmiedebergs Arch Pharmacol1988-12-01T00:00:001988Cyclic AMP-dependent and cyclic AMP-independent actions of a novel cardiotonic agent, OPC-8212.20723757Corbett KD, Yip CK, Ee LS, Walz T, Amon A, Harrison SCCellThe monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments. Cell. 2010 Aug 20; 142(4):556-67.Cell2010-08-20T00:00:002010The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments.23175357Alam SM, Liao HX, Tomaras GD, Bonsignori M, Tsao CY, Hwang KK, Chen H, Lloyd KE, Bowman C, Sutherland L, Jeffries TL, Kozink DM, Stewart S, Anasti K, Jaeger FH, Parks R, Yates NL, Overman RG, Sinangil F, Berman PW, Pitisuttithum P, Kaewkungwal J, Nitayaphan S, Karasavva N, Rerks-Ngarm S, Kim JH, Michael NL, Zolla-Pazner S, Santra S, Letvin NL, Harrison SC, Haynes BFJournal of virologyAntigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletion. J Virol. 2013 Feb; 87(3):1554-68.J Virol2012-11-21T00:00:002012Antigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletion.Authorship 1004694128811372Harrison SCProceedings of the National Academy of Sciences of the United States of AmericaPictures of the prologue to neurotransmitter release. Proc Natl Acad Sci U S A. 2017 08 22; 114(34):8920-8922.Proc Natl Acad Sci U S A2017-08-15T00:00:002017Pictures of the prologue to neurotransmitter release.20208545Abraham J, Corbett KD, Farzan M, Choe H, Harrison SCNature structural & molecular biologyStructural basis for receptor recognition by New World hemorrhagic fever arenaviruses. 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J Virol. 1977 Jul; 23(1):61-73.J Virol1977-07-01T00:00:001977Glycosidase susceptibility: a probe for the distribution of glycoprotein oligosaccharides in Sindbis virus.1701030Wang JH, Yan YW, Garrett TP, Liu JH, Rodgers DW, Garlick RL, Tarr GE, Husain Y, Reinherz EL, Harrison SCNatureAtomic structure of a fragment of human CD4 containing two immunoglobulin-like domains. Nature. 1990 Nov 29; 348(6300):411-8.Nature1990-11-29T00:00:001990Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains.15326297Lacy DB, Wigelsworth DJ, Melnyk RA, Harrison SC, Collier RJProceedings of the National Academy of Sciences of the United States of AmericaStructure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation. Proc Natl Acad Sci U S A. 2004 Sep 07; 101(36):13147-51.Proc Natl Acad Sci U S A2004-08-23T00:00:002004Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation.15698564Chen B, Vogan EM, Gong H, Skehel JJ, Wiley DC, Harrison SCStructure (London, England : 1993)Determining the structure of an unliganded and fully glycosylated SIV gp120 envelope glycoprotein. Structure. 2005 Feb; 13(2):197-211.Structure2005-02-01T00:00:002005Determining the structure of an unliganded and fully glycosylated SIV gp120 envelope glycoprotein.16908193Fotin A, Kirchhausen T, Grigorieff N, Harrison SC, Walz T, Cheng YJournal of structural biologyStructure determination of clathrin coats to subnanometer resolution by single particle cryo-electron microscopy. 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Proc Natl Acad Sci U S A. 1983 May; 80(9):2481-5.Proc Natl Acad Sci U S A1983-05-01T00:00:001983Location and distribution of the light chains in clathrin trimers.10644745Luongo CL, Reinisch KM, Harrison SC, Nibert MLThe Journal of biological chemistryIdentification of the guanylyltransferase region and active site in reovirus mRNA capping protein lambda2. J Biol Chem. 2000 Jan 28; 275(4):2804-10.J Biol Chem2000-01-28T00:00:002000Identification of the guanylyltransferase region and active site in reovirus mRNA capping protein lambda2.11867517Dormitzer PR, Sun ZY, Wagner G, Harrison SCThe EMBO journalThe rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site. 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Nature. 2005 Feb 24; 433(7028):834-41.Nature2005-02-24T00:00:002005Structure of an unliganded simian immunodeficiency virus gp120 core.17227844Larsen NA, Al-Bassam J, Wei RR, Harrison SCProceedings of the National Academy of Sciences of the United States of AmericaStructural analysis of Bub3 interactions in the mitotic spindle checkpoint. Proc Natl Acad Sci U S A. 2007 Jan 23; 104(4):1201-6.Proc Natl Acad Sci U S A2007-01-16T00:00:002007Structural analysis of Bub3 interactions in the mitotic spindle checkpoint.16339146Huang IC, Bosch BJ, Li F, Li W, Lee KH, Ghiran S, Vasilieva N, Dermody TS, Harrison SC, Dormitzer PR, Farzan M, Rottier PJ, Choe HThe Journal of biological chemistrySARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells. 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