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Harvard T.H. Chan School of Public Health
Associate Professor of Medicine, Part-time
Daniel K. Podolsky Professor of Medicine
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Biller LH, Horiguchi M, Uno H, Ukaegbu C, Syngal S, Yurgelun MB
Familial Burden and Other Clinical Factors Associated With Various Types of Cancer in Individuals With Lynch Syndrome. Gastroenterology. 2021 07; 161(1):143-150.e4.
Familial Burden and Other Clinical Factors Associated With Various Types of Cancer in Individuals With Lynch Syndrome.
Katona BW, Mahmud N, Dbouk M, Ahmad N, Chhoda A, Dudley B, Hayat U, Kwon RS, Lee LS, Rustgi AK, Ukaegbu C, Vasquez L, Volk S, Brand RE, Canto MI, Chak A, Farrell JJ, Kastrinos F, Stoffel EM, Syngal S, Goggins M
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
COVID-19 related pancreatic cancer surveillance disruptions amongst high-risk individuals. Pancreatology. 2021 Sep; 21(6):1048-1051.
COVID-19 related pancreatic cancer surveillance disruptions amongst high-risk individuals.
Dye-Based Chromoendoscopy in Patients With Lynch Syndrome: An Individual Patient Data Meta-Analysis of Randomized Trials. Am J Gastroenterol. 2021 04; 116(4):825-828.
Hsu FC, Roberts NJ, Childs E, Porter N, Rabe KG, Borgida A, Ukaegbu C, Goggins MG, Hruban RH, Zogopoulos G, Syngal S, Gallinger S, Petersen GM, Klein AP
Risk of Pancreatic Cancer Among Individuals With Pathogenic Variants in the ATM Gene. JAMA Oncol. 2021 Nov 01; 7(11):1664-1668.
Risk of Pancreatic Cancer Among Individuals With Pathogenic Variants in the ATM Gene.
Shaukat A, Marsh TL, Crockett SD, Syngal S, Bresalier RS, Brenner DE
Low Prevalence of Screen-Detected Colorectal Cancer in an Average-Risk Population: The New Normal. Clin Gastroenterol Hepatol. 2022 Nov; 20(11):2650-2652.e1.
Low Prevalence of Screen-Detected Colorectal Cancer in an Average-Risk Population: The New Normal.
Furniss CS, Yurgelun MB, Ukaegbu C, Constantinou PE, Lafferty CC, Talcove-Berko ER, Schwartz AN, Stopfer JE, Underhill-Blazey M, Kenner B, Nelson SH, Okumura S, Law S, Zhou AY, Coffin TB, Rodriguez NJ, Uno H, Ocean AJ, McAllister F, Lowy AM, Lippman SM, Klein AP, Madlensky L, Petersen GM, Garber JE, Goggins MG, Maitra A, Syngal S
Novel Models of Genetic Education and Testing for Pancreatic Cancer Interception: Preliminary Results from the GENERATE Study. Cancer Prev Res (Phila). 2021 11; 14(11):1021-1032.
Novel Models of Genetic Education and Testing for Pancreatic Cancer Interception: Preliminary Results from the GENERATE Study.
Katona BW, Brand RE, Canto MI, Chak A, Farrell JJ, Kastrinos F, Rustgi AK, Stoffel EM, Syngal S, Goggins M
Screening for Pancreatic Ductal Adenocarcinoma: Are We Asking the Impossible?-Letter. Cancer Prev Res (Phila). 2021 10; 14(10):973-974.
Screening for Pancreatic Ductal Adenocarcinoma: Are We Asking the Impossible?-Letter.
Bancroft EK, Page EC, Brook MN, Thomas S, Taylor N, Pope J, McHugh J, Jones AB, Karlsson Q, Merson S, Ong KR, Hoffman J, Huber C, Maehle L, Grindedal EM, Stormorken A, Evans DG, Rothwell J, Lalloo F, Brady AF, Bartlett M, Snape K, Hanson H, James P, McKinley J, Mascarenhas L, Syngal S, Ukaegbu C, Side L, Thomas T, Barwell J, Teixeira MR, Izatt L, Suri M, Macrae FA, Poplawski N, Chen-Shtoyerman R, Ahmed M, Musgrave H, Nicolai N, Greenhalgh L, Brewer C, Pachter N, Spigelman AD, Azzabi A, Helfand BT, Halliday D, Buys S, Ramon Y Cajal T, Donaldson A, Cooney KA, Harris M, McGrath J, Davidson R, Taylor A, Cooke P, Myhill K, Hogben M, Aaronson NK, Ardern-Jones A, Bangma CH, Castro E, Dearnaley D, Dias A, Dudderidge T, Eccles DM, Green K, Eyfjord J, Falconer A, Foster CS, Gronberg H, Hamdy FC, Johannsson O, Khoo V, Lilja H, Lindeman GJ, Lubinski J, Axcrona K, Mikropoulos C, Mitra AV, Moynihan C, Ni Raghallaigh H, Rennert G, Collier R, Offman J, Kote-Jarai Z, Eeles RA
A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (IMPACT): initial results from an international prospective study. Lancet Oncol. 2021 11; 22(11):1618-1631.
A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (IMPACT): initial results from an international prospective study.
Overbeek KA, Goggins MG, Dbouk M, Levink IJM, Koopmann BDM, Chuidian M, Konings ICAW, Paiella S, Earl J, Fockens P, Gress TM, Ausems MGEM, Poley JW, Thosani NC, Half E, Lachter J, Stoffel EM, Kwon RS, Stoita A, Kastrinos F, Lucas AL, Syngal S, Brand RE, Chak A, Carrato A, Vleggaar FP, Bartsch DK, van Hooft JE, Cahen DL, Canto MI, Bruno MJ
Timeline of Development of Pancreatic Cancer and Implications for Successful Early Detection in High-Risk Individuals. Gastroenterology. 2022 03; 162(3):772-785.e4.
Timeline of Development of Pancreatic Cancer and Implications for Successful Early Detection in High-Risk Individuals.
Blackford AL, Childs EJ, Porter N, Petersen GM, Rabe KG, Gallinger S, Borgida A, Syngal S, Cote ML, Schwartz AG, Goggins MG, Hruban RH, Parmigiani G, Klein AP
A risk prediction tool for individuals with a family history of breast, ovarian, or pancreatic cancer: BRCAPANCPRO. Br J Cancer. 2021 12; 125(12):1712-1717.
A risk prediction tool for individuals with a family history of breast, ovarian, or pancreatic cancer: BRCAPANCPRO.
Mittendorf KF, Knerr S, Kauffman TL, Lindberg NM, Anderson KP, Feigelson HS, Gilmore MJ, Hunter JE, Joseph G, Kraft SA, Zepp JM, Syngal S, Wilfond BS, Goddard KAB
Systemic Barriers to Risk-Reducing Interventions for Hereditary Cancer Syndromes: Implications for Health Care Inequities. JCO Precis Oncol. 2021; 5.
Systemic Barriers to Risk-Reducing Interventions for Hereditary Cancer Syndromes: Implications for Health Care Inequities.
Perez K, Kulke MH, Chittenden A, Ukaegbu C, Astone K, Alexander H, Brais L, Zhang J, Garcia J, Esplin ED, Yang S, Da Silva A, Nowak JA, Yurgelun MB, Garber J, Syngal S, Chan J
Clinical Implications of Pathogenic Germline Variants in Small Intestine Neuroendocrine Tumors (SI-NETs). JCO Precis Oncol. 2021 11; 5:808-816.
Clinical Implications of Pathogenic Germline Variants in Small Intestine Neuroendocrine Tumors (SI-NETs).
Amendola LM, Shuster E, Leo MC, Dorschner MO, Rolf BA, Shirts BH, Gilmore MJ, Okuyama S, Zepp JM, Kauffman TL, Mittendorf KF, Bellcross C, Jenkins CL, Joseph G, Riddle L, Syngal S, Ukaegbu C, Goddard KAB, Wilfond BS, Jarvik GP
Laboratory-related outcomes from integrating an accessible delivery model for hereditary cancer risk assessment and genetic testing in populations with barriers to access. Genet Med. 2022 06; 24(6):1196-1205.
Laboratory-related outcomes from integrating an accessible delivery model for hereditary cancer risk assessment and genetic testing in populations with barriers to access.
Giner-Calabuig M, De Leon S, Wang J, Fehlmann TD, Ukaegbu C, Gibson J, Alustiza-Fernandez M, Pico MD, Alenda C, Herraiz M, Carrillo-Palau M, Salces I, Reyes J, Ortega SP, Obrador-Hevia A, Cecchini M, Syngal S, Stoffel E, Ellis NA, Sweasy J, Jover R, Llor X, Xicola RM
Mutational signature profiling classifies subtypes of clinically different mismatch-repair-deficient tumours with a differential immunogenic response potential. Br J Cancer. 2022 06; 126(11):1595-1603.
Mutational signature profiling classifies subtypes of clinically different mismatch-repair-deficient tumours with a differential immunogenic response potential.
Boland CR, Idos GE, Durno C, Giardiello FM, Anderson JC, Burke CA, Dominitz JA, Gross S, Gupta S, Jacobson BC, Patel SG, Shaukat A, Syngal S, Robertson DJ
Diagnosis and Management of Cancer Risk in the Gastrointestinal Hamartomatous Polyposis Syndromes: Recommendations From the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2022 06; 162(7):2063-2085.
Diagnosis and Management of Cancer Risk in the Gastrointestinal Hamartomatous Polyposis Syndromes: Recommendations From the US Multi-Society Task Force on Colorectal Cancer.
Diagnosis and Management of Cancer Risk in the Gastrointestinal Hamartomatous Polyposis Syndromes: Recommendations From the US Multi-Society Task Force on Colorectal Cancer. Am J Gastroenterol. 2022 06 01; 117(6):846-864.
Diagnosis and management of cancer risk in the gastrointestinal hamartomatous polyposis syndromes: recommendations from the U.S. Multi-Society Task Force on Colorectal Cancer. Gastrointest Endosc. 2022 06; 95(6):1025-1047.
Diagnosis and management of cancer risk in the gastrointestinal hamartomatous polyposis syndromes: recommendations from the U.S. Multi-Society Task Force on Colorectal Cancer.
Dbouk M, Katona BW, Brand RE, Chak A, Syngal S, Farrell JJ, Kastrinos F, Stoffel EM, Blackford AL, Rustgi AK, Dudley B, Lee LS, Chhoda A, Kwon R, Ginsberg GG, Klein AP, Kamel I, Hruban RH, He J, Shin EJ, Lennon AM, Canto MI, Goggins M
The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival. J Clin Oncol. 2022 10 01; 40(28):3257-3266.
The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival.
Mittendorf KF, Lewis HS, Duenas DM, Eubanks DJ, Gilmore MJ, Goddard KAB, Joseph G, Kauffman TL, Kraft SA, Lindberg NM, Reyes AA, Shuster E, Syngal S, Ukaegbu C, Zepp JM, Wilfond BS, Porter KM
Literacy-adapted, electronic family history assessment for genetics referral in primary care: patient user insights from qualitative interviews. Hered Cancer Clin Pract. 2022 Jun 10; 20(1):22.
Literacy-adapted, electronic family history assessment for genetics referral in primary care: patient user insights from qualitative interviews.
Yurgelun MB, Uno H, Furniss CS, Ukaegbu C, Horiguchi M, Yussuf A, LaDuca H, Chittenden A, Garber JE, Syngal S
Development and Validation of the PREMMplus Model for Multigene Hereditary Cancer Risk Assessment. J Clin Oncol. 2022 12 10; 40(35):4083-4094.
Development and Validation of the PREMMplus Model for Multigene Hereditary Cancer Risk Assessment.
Dbouk M, Katona BW, Brand RE, Chak A, Syngal S, Farrell JJ, Kastrinos F, Stoffel EM, Canto MI, Goggins M
Shyr C, Blackford AL, Huang T, Ke J, Ouardaoui N, Trippa L, Syngal S, Ukaegbu C, Uno H, Nafa K, Stadler ZK, Offit K, Amos CI, Lynch PM, Chen S, Giardiello FM, Buchanan DD, Hopper JL, Jenkins MA, Southey MC, Win AK, Figueiredo JC, Braun D, Parmigiani G
A validation of models for prediction of pathogenic variants in mismatch repair genes. Genet Med. 2022 10; 24(10):2155-2166.
A validation of models for prediction of pathogenic variants in mismatch repair genes.
Rodriguez NJ, Ricker C, Stoffel EM, Syngal S
Barriers and Facilitators to Genetic Education, Risk Assessment, and Testing: Considerations on Advancing Equitable Genetics Care. Clin Gastroenterol Hepatol. 2023 01; 21(1):3-7.
Barriers and Facilitators to Genetic Education, Risk Assessment, and Testing: Considerations on Advancing Equitable Genetics Care.
Barriers and Facilitators to Genetic Education, Risk Assessment, and Testing: Considerations on Advancing Equitable Genetics Care. Gastroenterology. 2023 01; 164(1):5-8.
Cavestro GM, Mannucci A, Balaguer F, Hampel H, Kupfer SS, Repici A, Sartore-Bianchi A, Seppälä TT, Valentini V, Boland CR, Brand RE, Buffart TE, Burke CA, Caccialanza R, Cannizzaro R, Cascinu S, Cercek A, Crosbie EJ, Danese S, Dekker E, Daca-Alvarez M, Deni F, Dominguez-Valentin M, Eng C, Goel A, Guillem JG, Houwen BBSL, Kahi C, Kalady MF, Kastrinos F, Kühn F, Laghi L, Latchford A, Liska D, Lynch P, Malesci A, Mauri G, Meldolesi E, Møller P, Monahan KJ, Möslein G, Murphy CC, Nass K, Ng K, Oliani C, Papaleo E, Patel SG, Puzzono M, Remo A, Ricciardiello L, Ripamonti CI, Siena S, Singh SK, Stadler ZK, Stanich PP, Syngal S, Turi S, Urso ED, Valle L, Vanni VS, Vilar E, Vitellaro M, You YN, Yurgelun MB, Zuppardo RA, Stoffel EM
Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines. Clin Gastroenterol Hepatol. 2023 03; 21(3):581-603.e33.
Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines.
Knapp ST, Revette A, Underhill-Blazey M, Stopfer JE, Ukaegbu CI, Poulin C, Parenteau M, Syngal S, Bae E, Bickmore T, Hampel H, Idos GE, Parmigiani G, Yurgelun MB, Braun D
MyLynch: A Patient-Facing Clinical Decision Support Tool for Genetically-Guided Personalized Medicine in Lynch Syndrome. Cancers (Basel). 2023 Jan 06; 15(2).
MyLynch: A Patient-Facing Clinical Decision Support Tool for Genetically-Guided Personalized Medicine in Lynch Syndrome.
Zhong CS, Horiguchi M, Uno H, Ukaegbu C, Chittenden A, LeBoeuf NR, Syngal S, Nambudiri VE, Yurgelun MB
Journal of the American Academy of Dermatology
Clinical factors associated with skin neoplasms in individuals with Lynch syndrome in a longitudinal observational cohort. J Am Acad Dermatol. 2023 06; 88(6):1282-1290.
Clinical factors associated with skin neoplasms in individuals with Lynch syndrome in a longitudinal observational cohort.
Spaander MCW, Zauber AG, Syngal S, Blaser MJ, Sung JJ, You YN, Kuipers EJ
Young-onset colorectal cancer. Nat Rev Dis Primers. 2023 04 27; 9(1):21.
Sandoval RL, Horiguchi M, Ukaegbu C, Furniss CS, Uno H, Syngal S, Yurgelun MB
PREMM5 distinguishes sporadic from Lynch syndrome-associated MMR-deficient/MSI-high colorectal cancer. Fam Cancer. 2023 10; 22(4):459-465.
PREMM5 distinguishes sporadic from Lynch syndrome-associated MMR-deficient/MSI-high colorectal cancer.
Rodriguez NJ, Furniss CS, Yurgelun MB, Ukaegbu C, Constantinou PE, Fortes I, Caruso A, Schwartz AN, Stopfer JE, Underhill-Blazey M, Kenner B, Nelson SH, Okumura S, Zhou AY, Coffin TB, Uno H, Horiguchi M, Ocean AJ, McAllister F, Lowy AM, Klein AP, Madlensky L, Petersen GM, Garber JE, Lippman SM, Goggins MG, Maitra A, Syngal S
A Randomized Trial of Two Remote Health Care Delivery Models on the Uptake of Genetic Testing and Impact on Patient-Reported Psychological Outcomes in Families With Pancreatic Cancer: The Genetic Education, Risk Assessment, and Testing (GENERATE) Study. Gastroenterology. 2024 05; 166(5):872-885.e2.
A Randomized Trial of Two Remote Health Care Delivery Models on the Uptake of Genetic Testing and Impact on Patient-Reported Psychological Outcomes in Families With Pancreatic Cancer: The Genetic Education, Risk Assessment, and Testing (GENERATE) Study.
Great Lakes New England Clinical Validation Center
Maoz A, Rodriguez NJ, Yurgelun MB, Syngal S
Hematology/oncology clinics of North America
Gastrointestinal Cancer Precursor Conditions and Their Detection. Hematol Oncol Clin North Am. 2024 08; 38(4):783-811.
Gastrointestinal Cancer Precursor Conditions and Their Detection.
Expanding access to genetic testing for pancreatic cancer. Fam Cancer. 2024 08; 23(3):247-254.
Expanding access to genetic testing for pancreatic cancer.
Blackford AL, Canto MI, Dbouk M, Hruban RH, Katona BW, Chak A, Brand RE, Syngal S, Farrell J, Kastrinos F, Stoffel EM, Rustgi A, Klein AP, Kamel I, Fishman EK, He J, Burkhart R, Shin EJ, Lennon AM, Goggins M
Pancreatic Cancer Surveillance and Survival of High-Risk Individuals. JAMA Oncol. 2024 Aug 01; 10(8):1087-1096.
Pancreatic Cancer Surveillance and Survival of High-Risk Individuals.
May FP, Brodney S, Tuan JJ, Syngal S, Chan AT, Glenn B, Johnson G, Chang Y, Drew DA, Moy B, Rodriguez NJ, Warner ET, Anyane-Yeboa A, Ukaegbu C, Davis AQ, Schoolcraft K, Regan S, Yoguez N, Kuney S, Le Beaux K, Jeffries C, Lee ET, Bhat R, Haas JS
Community Collaboration to Advance Racial/Ethnic Equity in Colorectal Cancer Screening: Protocol for a Multilevel Intervention to Improve Screening and Follow-up in Community Health Centers. Contemp Clin Trials. 2024 Oct; 145:107639.
Community Collaboration to Advance Racial/Ethnic Equity in Colorectal Cancer Screening: Protocol for a Multilevel Intervention to Improve Screening and Follow-up in Community Health Centers.
Design of a Scalable and Sustainable PREMMplus Patient-Facing App and Implementation in Three Healthcare Settings
Kanda M, Sadakari Y, Borges M, Topazian M, Farrell J, Syngal S, Lee J, Kamel I, Lennon AM, Knight S, Fujiwara S, Hruban RH, Canto MI, Goggins M
Mutant TP53 in duodenal samples of pancreatic juice from patients with pancreatic cancer or high-grade dysplasia. Clin Gastroenterol Hepatol. 2013 Jun; 11(6):719-30.e5.
Mutant TP53 in duodenal samples of pancreatic juice from patients with pancreatic cancer or high-grade dysplasia.
Prediction models in Lynch syndrome. Fam Cancer. 2013 Jun; 12(2):217-28.
Kanda M, Knight S, Topazian M, Syngal S, Farrell J, Lee J, Kamel I, Lennon AM, Borges M, Young A, Fujiwara S, Seike J, Eshleman J, Hruban RH, Canto MI, Goggins M
Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts. Gut. 2013 Jul; 62(7):1024-33.
Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts.
Raymond VM, Mukherjee B, Wang F, Huang SC, Stoffel EM, Kastrinos F, Syngal S, Cooney KA, Gruber SB
Elevated risk of prostate cancer among men with Lynch syndrome. J Clin Oncol. 2013 May 10; 31(14):1713-8.
Elevated risk of prostate cancer among men with Lynch syndrome.
Crockett SD, Shaukat A, Delau O, Stoffel EM, Church TR, Syngal S, Bresalier R
Risk Factors for Serrated Polyps: Results From a Large, Multicenter Colonoscopy-Based Study. Am J Gastroenterol. 2024 Dec 01; 119(12):2532-2539.
Risk Factors for Serrated Polyps: Results From a Large, Multicenter Colonoscopy-Based Study.
Biller LH, Mittendorf K, Horiguchi M, Caruso A, Chittenden A, Ukaegbu C, Uno H, Syngal S, Yurgelun MB
Comparison of PREMM5 and PREMMplus Risk Assessment Models to Identify Lynch Syndrome. JCO Precis Oncol. 2025 Jan; 9:e2400691.
Comparison of PREMM5 and PREMMplus Risk Assessment Models to Identify Lynch Syndrome.
Landry KK, DeSarno MJ, Kipnis L, Barquet Ramos F, Breen KM, Patton K, Morrissette A, Buehler RM, Ukaegbu C, Rohanizadegan M, Yurgelun MB, Syngal S, Rana HQ, Garber JE
Prevalence and Distribution of Unexpected Actionable Germline Pathogenic Variants Identified on Broad-Based Multigene Panel Testing Among Patients With Cancer. JCO Precis Oncol. 2024 Dec; 8:e2400553.
Prevalence and Distribution of Unexpected Actionable Germline Pathogenic Variants Identified on Broad-Based Multigene Panel Testing Among Patients With Cancer.
Feigelson HS, Mittendorf KF, Okuyama S, Porter KM, Bulkley J, Shuster E, Anderson KP, Gilmore MJ, Zepp JM, Kauffman TL, Lindberg NM, Muessig KR, Bellcross C, Ukaegbu C, Syngal S, Leo MC, Wilfond BS
Feasibility of an electronic patient-facing cancer family history tool in medically underserved populations. Genet Med Open. 2024; 2:101860.
Feasibility of an electronic patient-facing cancer family history tool in medically underserved populations.
Perencevich M, Ojha RP, Steyerberg EW, Syngal S
Racial and ethnic variations in the effects of family history of colorectal cancer on screening compliance. Gastroenterology. 2013 Oct; 145(4):775-81.e2.
Racial and ethnic variations in the effects of family history of colorectal cancer on screening compliance.
Latham A, Liu YL, Constantino G, Borio M, McCoy S, Dudzik C, Heiman J, Kemel Y, Ukaegbu C, Carlo MI, Ranganathan M, Kane S, Long JM, Syngal S, Markowitz AJ, Stadler ZK, Yurgelun MB, Katona BW
Neoplasia Detection Through Colonic Surveillance Among Young Individuals With MSH6 / PMS2 -Associated Lynch Syndrome. Am J Gastroenterol. 2025 Nov 01; 120(11):2670-2678.
Neoplasia Detection Through Colonic Surveillance Among Young Individuals With MSH6 / PMS2 -Associated Lynch Syndrome.
Erratum: Comparison of PREMM5 and PREMMplus Risk Assessment Models to Identify Lynch Syndrome. JCO Precis Oncol. 2025 Feb; 9:e2500058.
Erratum: Comparison of PREMM5 and PREMMplus Risk Assessment Models to Identify Lynch Syndrome.
Feldman D, Rodgers-Fouche LH, Ukaegbu C, Yurgelun MB, Syngal S, Chung DC
Cancer Incidence and Mortality in Familial Adenomatous Polyposis Syndrome. Dis Colon Rectum. 2025 May 01; 68(5):531-543.
Cancer Incidence and Mortality in Familial Adenomatous Polyposis Syndrome.
Rodriguez NJ, Coffin TB, Ward AJ, Rodriguez JF, Ukaegbu C, Rosenzweig A, Caruso A, Revette A, Kenner B, Nelson SH, Goggins M, Maitra A, Syngal S
A Mixed-Methods Approach to Assessing Barriers and Facilitators to Cancer Genetics Care in Black and Latino/a Individuals Impacted by Pancreatic Cancer: The Racial/ethnic Equity in GENetic Education, Risk Assessment, and TEsting (REGENERATE) Study. Dig Dis Sci. 2025 Aug; 70(8):2635-2654.
A Mixed-Methods Approach to Assessing Barriers and Facilitators to Cancer Genetics Care in Black and Latino/a Individuals Impacted by Pancreatic Cancer: The Racial/ethnic Equity in GENetic Education, Risk Assessment, and TEsting (REGENERATE) Study.
Yurgelun MB, Hornick JL, Curry VK, Ukaegbu CI, Brown EK, Hiller E, Chittenden A, Goldberg JE, Syngal S
Therapy-associated polyposis as a late sequela of cancer treatment. Clin Gastroenterol Hepatol. 2014 Jun; 12(6):1046-50.
Therapy-associated polyposis as a late sequela of cancer treatment.
Ma T, Jang EJ, Zukerberg LR, Odze R, Gala MK, Kelsey PB, Forcione DG, Brugge WR, Casey BW, Syngal S, Chung DC
Recurrences are common after endoscopic ampullectomy for adenoma in the familial adenomatous polyposis (FAP) syndrome. Surg Endosc. 2014 Aug; 28(8):2349-56.
Recurrences are common after endoscopic ampullectomy for adenoma in the familial adenomatous polyposis (FAP) syndrome.
Lu KH, Wood ME, Daniels M, Burke C, Ford J, Kauff ND, Kohlmann W, Lindor NM, Mulvey TM, Robinson L, Rubinstein WS, Stoffel EM, Snyder C, Syngal S, Merrill JK, Wollins DS, Hughes KS
American Society of Clinical Oncology Expert Statement: collection and use of a cancer family history for oncology providers. J Clin Oncol. 2014 Mar 10; 32(8):833-40.
American Society of Clinical Oncology Expert Statement: collection and use of a cancer family history for oncology providers.
Pradhan P, Ghobrial IM, Marinac CR, O'Donnell EK, Syngal S, Weeks LD, Rebbeck TR
Opportunities to Avoid Invasive Cancer by Diagnosis and Interception of Preneoplastic Lesions and Cancer Risk Conditions. Cancer Epidemiol Biomarkers Prev. 2026 Jan 09; 35(1):67-78.
Opportunities to Avoid Invasive Cancer by Diagnosis and Interception of Preneoplastic Lesions and Cancer Risk Conditions.
Maoz A, Biller L, Giannakis M, Rubinson D, Jayakrishnan T, Horiguchi M, Ukaegbu C, Caruso A, Syngal S, Yurgelun MB
Causes of Death Among Individuals With Lynch Syndrome in the Immunotherapy Era. JCO Precis Oncol. 2025 Oct; 9:e2500700.
Causes of Death Among Individuals With Lynch Syndrome in the Immunotherapy Era.
Giardiello FM, Allen JI, Axilbund JE, Boland CR, Burke CA, Burt RW, Church JM, Dominitz JA, Johnson DA, Kaltenbach T, Levin TR, Lieberman DA, Robertson DJ, Syngal S, Rex DK
Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the U.S. Multi-Society Task Force on Colorectal Cancer. Gastrointest Endosc. 2014 Aug; 80(2):197-220.
Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the U.S. Multi-Society Task Force on Colorectal Cancer.
Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on Colorectal Cancer. Dis Colon Rectum. 2014 08; 57(8):1025-48.
Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on Colorectal Cancer.
Associate Professor of Clinical Epidemiology and Nutrition
Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on colorectal cancer. Gastroenterology. 2014 Aug; 147(2):502-26.
Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on colorectal cancer.
Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-society Task Force on colorectal cancer. Am J Gastroenterol. 2014 Aug; 109(8):1159-79.
Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-society Task Force on colorectal cancer.
Greaney ML, Puleo E, Sprunck-Harrild K, Syngal S, Suarez EG, Emmons KM
Changes in colorectal cancer screening intention among people aged 18-49 in the United States. BMC Public Health. 2014 Sep 01; 14:901.
Changes in colorectal cancer screening intention among people aged 18-49 in the United States.
Underhill M, Berry D, Dalton E, Schienda J, Syngal S
Patient experiences living with pancreatic cancer risk. Hered Cancer Clin Pract. 2015; 13(1):13.
Patient experiences living with pancreatic cancer risk.
Colorectal cancer in young adults. Dig Dis Sci. 2015 Mar; 60(3):722-33.
Rastegar N, Matteoni-Athayde LG, Eng J, Takahashi N, Tamm EP, Mortele KJ, Syngal S, Margolis D, Lennon AM, Wolfgang CL, Fishman EK, Hruban RH, Goggins M, Canto MI, Kamel IR
Incremental value of secretin-enhanced magnetic resonance cholangiopancreatography in detecting ductal communication in a population with high prevalence of small pancreatic cysts. Eur J Radiol. 2015 Apr; 84(4):575-80.
Incremental value of secretin-enhanced magnetic resonance cholangiopancreatography in detecting ductal communication in a population with high prevalence of small pancreatic cysts.
Everett JN, Raymond VM, Dandapani M, Marvin M, Kohlmann W, Chittenden A, Koeppe E, Gustafson SL, Else T, Fullen DR, Johnson TM, Syngal S, Gruber SB, Stoffel EM
Screening for germline mismatch repair mutations following diagnosis of sebaceous neoplasm. JAMA Dermatol. 2014 Dec; 150(12):1315-21.
Screening for germline mismatch repair mutations following diagnosis of sebaceous neoplasm.
Eshleman JR, Norris AL, Sadakari Y, Debeljak M, Borges M, Harrington C, Lin E, Brant A, Barkley T, Almario JA, Topazian M, Farrell J, Syngal S, Lee JH, Yu J, Hruban RH, Kanda M, Canto MI, Goggins M
KRAS and guanine nucleotide-binding protein mutations in pancreatic juice collected from the duodenum of patients at high risk for neoplasia undergoing endoscopic ultrasound. Clin Gastroenterol Hepatol. 2015 May; 13(5):963-9.e4.
KRAS and guanine nucleotide-binding protein mutations in pancreatic juice collected from the duodenum of patients at high risk for neoplasia undergoing endoscopic ultrasound.
Syngal S, Brand RE, Church JM, Giardiello FM, Hampel HL, Burt RW
ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes. Am J Gastroenterol. 2015 Feb; 110(2):223-62; quiz 263.
ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes.
Zhen DB, Rabe KG, Gallinger S, Syngal S, Schwartz AG, Goggins MG, Hruban RH, Cote ML, McWilliams RR, Roberts NJ, Cannon-Albright LA, Li D, Moyes K, Wenstrup RJ, Hartman AR, Seminara D, Klein AP, Petersen GM
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Stoffel EM, Turgeon DK, Stockwell DH, Normolle DP, Tuck MK, Marcon NE, Baron JA, Bresalier RS, Arber N, Ruffin MT, Syngal S, Brenner DE
Chromoendoscopy detects more adenomas than colonoscopy using intensive inspection without dye spraying. Cancer Prev Res (Phila). 2008 Dec; 1(7):507-13.
Chromoendoscopy detects more adenomas than colonoscopy using intensive inspection without dye spraying.
Kastrinos F, Mukherjee B, Tayob N, Wang F, Sparr J, Raymond VM, Bandipalliam P, Stoffel EM, Gruber SB, Syngal S
Risk of pancreatic cancer in families with Lynch syndrome. JAMA. 2009 Oct 28; 302(16):1790-5.
Risk of pancreatic cancer in families with Lynch syndrome.
Canto MI, Hruban RH, Fishman EK, Kamel IR, Schulick R, Zhang Z, Topazian M, Takahashi N, Fletcher J, Petersen G, Klein AP, Axilbund J, Griffin C, Syngal S, Saltzman JR, Mortele KJ, Lee J, Tamm E, Vikram R, Bhosale P, Margolis D, Farrell J, Goggins M
Frequent detection of pancreatic lesions in asymptomatic high-risk individuals. Gastroenterology. 2012 Apr; 142(4):796-804; quiz e14-5.
Frequent detection of pancreatic lesions in asymptomatic high-risk individuals.
Screening patients with colorectal cancer for Lynch syndrome: what are we waiting for? J Clin Oncol. 2012 Apr 01; 30(10):1024-7.
Screening patients with colorectal cancer for Lynch syndrome: what are we waiting for?
Early predictors of severity in acute lower intestinal tract bleeding. Arch Intern Med. 2003 Apr 14; 163(7):838-43.
Early predictors of severity in acute lower intestinal tract bleeding.
Stockwell DH, Woo P, Jacobson BC, Remily R, Syngal S, Wolf J, Farraye FA
Determinants of colorectal cancer screening in women undergoing mammography. Am J Gastroenterol. 2003 Aug; 98(8):1875-80.
Determinants of colorectal cancer screening in women undergoing mammography.
Bandipalliam P, Garber J, Kolodner RD, Syngal S
Clinical presentation correlates with the type of mismatch repair gene involved in hereditary nonpolyposis colon cancer. Gastroenterology. 2004 Mar; 126(3):936-7.
Clinical presentation correlates with the type of mismatch repair gene involved in hereditary nonpolyposis colon cancer.
Dewanwala A, Chittenden A, Rosenblatt M, Mercado R, Garber JE, Syngal S, Stoffel EM
Attitudes toward childbearing and prenatal testing in individuals undergoing genetic testing for Lynch syndrome. Fam Cancer. 2011 Sep; 10(3):549-56.
Attitudes toward childbearing and prenatal testing in individuals undergoing genetic testing for Lynch syndrome.
Adenomas in young patients: what is the optimal evaluation? Am J Gastroenterol. 2005 May; 100(5):1150-3.
Adenomas in young patients: what is the optimal evaluation?
Steyerberg EW, Uno H, Ioannidis JPA, van Calster B
Poor performance of clinical prediction models: the harm of commonly applied methods. J Clin Epidemiol. 2018 06; 98:133-143.
Poor performance of clinical prediction models: the harm of commonly applied methods.
Kastrinos F, Steyerberg EW, Mercado R, Balmaña J, Holter S, Gallinger S, Siegmund KD, Church JM, Jenkins MA, Lindor NM, Thibodeau SN, Burbidge LA, Wenstrup RJ, Syngal S
The PREMM(1,2,6) model predicts risk of MLH1, MSH2, and MSH6 germline mutations based on cancer history. Gastroenterology. 2011 Jan; 140(1):73-81.
The PREMM(1,2,6) model predicts risk of MLH1, MSH2, and MSH6 germline mutations based on cancer history.
Kastrinos F, Allen JI, Stockwell DH, Stoffel EM, Cook EF, Mutinga ML, Balmaña J, Syngal S
Development and validation of a colon cancer risk assessment tool for patients undergoing colonoscopy. Am J Gastroenterol. 2009 Jun; 104(6):1508-18.
Development and validation of a colon cancer risk assessment tool for patients undergoing colonoscopy.
Best practice & research. Clinical gastroenterology
Genetic testing in gastroenterology: Lynch syndrome. Best Pract Res Clin Gastroenterol. 2009; 23(2):185-96.
Genetic testing in gastroenterology: Lynch syndrome.
Journal of the National Comprehensive Cancer Network : JNCCN
Risk assessment, genetic testing, and management of Lynch syndrome. J Natl Compr Canc Netw. 2010 Jan; 8(1):98-105.
Risk assessment, genetic testing, and management of Lynch syndrome.
Hereditary pancreatic cancer. Gastroenterology. 2010 Oct; 139(4):1076-80, 1080.e1-2.
Commentary: PREMM5 threshold of 2.5% is recommended to improve identification of PMS2 carriers. Fam Cancer. 2018 10; 17(4):567.
Commentary: PREMM5 threshold of 2.5% is recommended to improve identification of PMS2 carriers.
One less thing to worry about: the shrinking spectrum of tumors in BRCA founder mutation carriers. J Natl Cancer Inst. 2004 Jan 07; 96(1):2-3.
One less thing to worry about: the shrinking spectrum of tumors in BRCA founder mutation carriers.
Cancer risk assessment: quality and impact of the family history interview. Am J Prev Med. 2004 Oct; 27(3):239-45.
Cancer risk assessment: quality and impact of the family history interview.
Strate LL, Saltzman JR, Ookubo R, Mutinga ML, Syngal S
Validation of a clinical prediction rule for severe acute lower intestinal bleeding. Am J Gastroenterol. 2005 Aug; 100(8):1821-7.
Validation of a clinical prediction rule for severe acute lower intestinal bleeding.