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James Stillman Professor of Developmental Biology
Professor of Biological Chemistry and Molecular Pharmacology
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SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling. Cell Stem Cell. 2022 01 06; 29(1):101-115.e10.
SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling.
Bhattacharya S, Wolfenson H, Shivdasani R, Shalom-Feuerstein R
Stem cell responses to stretch and strain. Trends Cell Biol. 2022 01; 32(1):4-7.
Stem cell responses to stretch and strain.
The hens guarding epithelial cancer fox-houses. Cell Res. 2022 03; 32(3):225-226.
The hens guarding epithelial cancer fox-houses.
Singh H, Seruggia D, Madha S, Saxena M, Nagaraja AK, Wu Z, Zhou J, Huebner AJ, Maglieri A, Wezenbeek J, Hochedlinger K, Orkin SH, Bass AJ, Hornick JL, Shivdasani RA
Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer. Genes Dev. 2022 01 01; 36(1-2):38-52.
Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer.
Singh PNP, Madha S, Leiter AB, Shivdasani RA
Cell and chromatin transitions in intestinal stem cell regeneration. Genes Dev. 2022 06 01; 36(11-12):684-698.
Cell and chromatin transitions in intestinal stem cell regeneration.
Manieri E, Tie G, Seruggia D, Madha S, Maglieri A, Huang K, Fujiwara Y, Zhang K, Orkin SH, He R, McCarthy N, Shivdasani RA
bioRxiv : the preprint server for biology
Defining the structure, signals, and cellular elements of the gastric mesenchymal niche. bioRxiv. 2023 Feb 24.
Defining the structure, signals, and cellular elements of the gastric mesenchymal niche.
McCarthy N, Tie G, Madha S, He R, Kraiczy J, Maglieri A, Shivdasani RA
Smooth muscle contributes to the development and function of a layered intestinal stem cell niche. Dev Cell. 2023 04 10; 58(7):550-564.e6.
Smooth muscle contributes to the development and function of a layered intestinal stem cell niche.
Kraiczy J, McCarthy N, Malagola E, Tie G, Madha S, Boffelli D, Wagner DE, Wang TC, Shivdasani RA
Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche. Cell Stem Cell. 2023 04 06; 30(4):433-449.e8.
Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche.
Kalra G, Lenz D, Abdul-Aziz D, Hanna C, Basu M, Herb BR, Colantuoni C, Milon B, Saxena M, Shetty AC, Hertzano R, Shivdasani RA, Ament SA, Edge ASB
Cochlear organoids reveal transcriptional programs of postnatal hair cell differentiation from supporting cells. Cell Rep. 2023 11 28; 42(11):113421.
Cochlear organoids reveal transcriptional programs of postnatal hair cell differentiation from supporting cells.
Manieri E, Tie G, Malagola E, Seruggia D, Madha S, Maglieri A, Huang K, Fujiwara Y, Zhang K, Orkin SH, Wang TC, He R, McCarthy N, Shivdasani RA
Role of PDGFRA+ cells and a CD55+ PDGFRALo fraction in the gastric mesenchymal niche. Nat Commun. 2023 12 02; 14(1):7978.
Role of PDGFRA+ cells and a CD55+ PDGFRALo fraction in the gastric mesenchymal niche.
Singh PNP, Gu W, Madha S, Lynch AW, Cejas P, He R, Bhattacharya S, Gomez MM, Oser MG, Brown M, Long HW, Meyer CA, Zhou Q, Shivdasani RA
Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation. bioRxiv. 2024 Jan 09.
Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation.
Singh PNP, Gu W, Madha S, Lynch AW, Cejas P, He R, Bhattacharya S, Muñoz Gomez M, Oser MG, Brown M, Long HW, Meyer CA, Zhou Q, Shivdasani RA
Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation. Cell Stem Cell. 2024 Jul 05; 31(7):1038-1057.e11.
Gu W, Huang X, Singh PNP, Li S, Lan Y, Deng M, Lacko LA, Gomez-Salinero JM, Rafii S, Verzi MP, Shivdasani RA, Zhou Q
A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin. Nat Commun. 2024 Apr 27; 15(1):3595.
A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin.
Imada S, Khawaled S, Shin H, Meckelmann SW, Whittaker CA, Corrêa RO, Alquati C, Lu Y, Tie G, Pradhan D, Calibasi-Kocal G, Nascentes Melo LM, Allies G, Rösler J, Wittenhofer P, Krystkiewicz J, Schmitz OJ, Roper J, Vinolo MAR, Ricciardiello L, Lien EC, Vander Heiden MG, Shivdasani RA, Cheng CW, Tasdogan A, Yilmaz ÖH
Short-term post-fast refeeding enhances intestinal stemness via polyamines. Nature. 2024 09; 633(8031):895-904.
Short-term post-fast refeeding enhances intestinal stemness via polyamines.
Pignon JC, Grisanzio C, Geng Y, Song J, Shivdasani RA, Signoretti S
p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8105-10.
p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia.
Gaynor L, Singh H, Tie G, Badarinath K, Madha S, Mancini A, Bhattacharya S, Hoshino M, de Sauvage FJ, Murata K, Jadhav U, Shivdasani RA
Crypt density and recruited enhancers underlie intestinal tumour initiation. Nature. 2025 04; 640(8057):231-239.
Crypt density and recruited enhancers underlie intestinal tumour initiation.
Pellon-Cardenas O, Rout P, Hassan S, Fokas E, Ping H, Patel I, Patel J, Plotsker O, Wu A, Kumar R, Akther M, Logerfo A, Wu S, Wagner DE, Boffelli D, Walton KD, Manieri E, Tong K, Spence JR, Bessman NJ, Shivdasani RA, Verzi MP
Dynamic Reprogramming of Stromal Pdgfra-expressing cells during WNT-Mediated Transformation of the Intestinal Epithelium. bioRxiv. 2025 Jan 25.
Dynamic Reprogramming of Stromal Pdgfra-expressing cells during WNT-Mediated Transformation of the Intestinal Epithelium.
Bhattacharya S, Tei G, Singh PNP, Malagola E, Eskiocak O, He R, Kraiczy J, Gu W, Perlov Y, Beyaz S, Wang TC, Zhou Q, Shivdasani RA
Niche-driven phenotypic plasticity and cis-regulatory dynamics of a revised model for intestinal secretory differentiation. bioRxiv. 2025 Feb 08.
Niche-driven phenotypic plasticity and cis-regulatory dynamics of a revised model for intestinal secretory differentiation.
Francis JM, Kiezun A, Ramos AH, Serra S, Pedamallu CS, Qian ZR, Banck MS, Kanwar R, Kulkarni AA, Karpathakis A, Manzo V, Contractor T, Philips J, Nickerson E, Pho N, Hooshmand SM, Brais LK, Lawrence MS, Pugh T, McKenna A, Sivachenko A, Cibulskis K, Carter SL, Ojesina AI, Freeman S, Jones RT, Voet D, Saksena G, Auclair D, Onofrio R, Shefler E, Sougnez C, Grimsby J, Green L, Lennon N, Meyer T, Caplin M, Chung DC, Beutler AS, Ogino S, Thirlwell C, Shivdasani R, Asa SL, Harris CR, Getz G, Kulke M, Meyerson M
Somatic mutation of CDKN1B in small intestine neuroendocrine tumors. Nat Genet. 2013 Dec; 45(12):1483-6.
Somatic mutation of CDKN1B in small intestine neuroendocrine tumors.
Epigenetic fluidity meets phenotypic malleability in intestinal epithelial cells. Cell Chem Biol. 2025 Mar 20; 32(3):389-391.
Epigenetic fluidity meets phenotypic malleability in intestinal epithelial cells.
Bhattacharya S, Tie G, Singh PNP, Malagola E, Eskiocak O, He R, Kraiczy J, Gu W, Perlov Y, Alici-Garipcan A, Beyaz S, Wang TC, Zhou Q, Shivdasani RA
Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell. Cell Stem Cell. 2025 Jun 05; 32(6):952-969.e8.
Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cell.
Liu T, Li S, Múnera JO, Shivdasani RA, Huang X, Zhou Q
Remodelling the Colon With Ileal Properties to Treat Short Bowel Syndrome. Gastroenterology. 2025 Aug; 169(2):352-355.e3.
Remodelling the Colon With Ileal Properties to Treat Short Bowel Syndrome.
Radiation redux: reserve intestinal stem cells miss the call to duty. Cell Stem Cell. 2014 Feb 06; 14(2):135-6.
Radiation redux: reserve intestinal stem cells miss the call to duty.
Kim TH, Li F, Ferreiro-Neira I, Ho LL, Luyten A, Nalapareddy K, Long H, Verzi M, Shivdasani RA
Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity. Nature. 2014 Feb 27; 506(7489):511-5.
Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity.
San Roman AK, Jayewickreme CD, Murtaugh LC, Shivdasani RA
Wnt secretion from epithelial cells and subepithelial myofibroblasts is not required in the mouse intestinal stem cell niche in vivo. Stem Cell Reports. 2014 Feb 11; 2(2):127-34.
Wnt secretion from epithelial cells and subepithelial myofibroblasts is not required in the mouse intestinal stem cell niche in vivo.
Reply. Gastroenterology. 2026 Jan; 170(1):223-224.
Niche regulation of gastric epithelial cell differentiation
Sulahian R, Casey F, Shen J, Qian ZR, Shin H, Ogino S, Weir BA, Vazquez F, Liu XS, Hahn WC, Bass AJ, Chan V, Shivdasani RA
An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer. Oncogene. 2014 Dec 04; 33(49):5637-48.
An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer.
Morris SA, Cahan P, Li H, Zhao AM, San Roman AK, Shivdasani RA, Collins JJ, Daley GQ
Dissecting engineered cell types and enhancing cell fate conversion via CellNet. Cell. 2014 Aug 14; 158(4):889-902.
Dissecting engineered cell types and enhancing cell fate conversion via CellNet.
Active enhancers are delineated de novo during hematopoiesis, with limited lineage fidelity among specified primary blood cells. Genes Dev. 2014 Aug 15; 28(16):1827-39.
Active enhancers are delineated de novo during hematopoiesis, with limited lineage fidelity among specified primary blood cells.
Feng R, Aihara E, Kenny S, Yang L, Li J, Varro A, Montrose MH, Shroyer NF, Wang TC, Shivdasani RA, Zavros Y
Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice. Gastroenterology. 2014 Sep; 147(3):655-666.e9.
Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice.
Verzi MP, Shin H, San Roman AK, Liu XS, Shivdasani RA
Erratum for Verzi et al., Intestinal Master Transcription Factor CDX2 Controls Chromatin Access for Partner Transcription Factor Binding. Mol Cell Biol. 2015 Jan 15; 35(2):496.
Erratum for Verzi et al., Intestinal Master Transcription Factor CDX2 Controls Chromatin Access for Partner Transcription Factor Binding.
Schumacher MA, Aihara E, Feng R, Engevik A, Shroyer NF, Ottemann KM, Worrell RT, Montrose MH, Shivdasani RA, Zavros Y
The use of murine-derived fundic organoids in studies of gastric physiology. J Physiol. 2015 Apr 15; 593(8):1809-27.
The use of murine-derived fundic organoids in studies of gastric physiology.
San Roman AK, Aronson BE, Krasinski SD, Shivdasani RA, Verzi MP
Transcription factors GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2. J Biol Chem. 2015 Jan 16; 290(3):1850-60.
Transcription factors GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2.
Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1. Dev Biol. 2015 Sep 01; 405(1):21-32.
Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1.
Pomerantz MM, Li F, Takeda DY, Lenci R, Chonkar A, Chabot M, Cejas P, Vazquez F, Cook J, Shivdasani RA, Bowden M, Lis R, Hahn WC, Kantoff PW, Brown M, Loda M, Long HW, Freedman ML
The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis. Nat Genet. 2015 Nov; 47(11):1346-51.
The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis.
San Roman AK, Tovaglieri A, Breault DT, Shivdasani RA
Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells. Stem Cell Reports. 2015 Nov 10; 5(5):673-681.
Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells.
Hanyuda A, Kim SA, Martinez-Fernandez A, Qian ZR, Yamauchi M, Nishihara R, Morikawa T, Liao X, Inamura K, Mima K, Cao Y, Zhang X, Wu K, Chan AT, Giovannucci EL, Meyerhardt JA, Fuchs CS, Shivdasani RA, Ogino S
Survival Benefit of Exercise Differs by Tumor IRS1 Expression Status in Colorectal Cancer. Ann Surg Oncol. 2016 Mar; 23(3):908-17.
Survival Benefit of Exercise Differs by Tumor IRS1 Expression Status in Colorectal Cancer.
Ariyachet C, Tovaglieri A, Xiang G, Lu J, Shah MS, Richmond CA, Verbeke C, Melton DA, Stanger BZ, Mooney D, Shivdasani RA, Mahony S, Xia Q, Breault DT, Zhou Q
Reprogrammed Stomach Tissue as a Renewable Source of Functional ß Cells for Blood Glucose Regulation. Cell Stem Cell. 2016 Mar 03; 18(3):410-21.
Reprogrammed Stomach Tissue as a Renewable Source of Functional ß Cells for Blood Glucose Regulation.
Stomach development, stem cells and disease. Development. 2016 Feb 15; 143(4):554-65.
Stomach development, stem cells and disease.
Bertaux-Skeirik N, Centeno J, Feng R, Schumacher MA, Shivdasani RA, Zavros Y
Methods in molecular biology (Clifton, N.J.)
Co-culture of Gastric Organoids and Immortalized Stomach Mesenchymal Cells. Methods Mol Biol. 2016; 1422:23-31.
Co-culture of Gastric Organoids and Immortalized Stomach Mesenchymal Cells.
Jadhav U, Nalapareddy K, Saxena M, O'Neill NK, Pinello L, Yuan GC, Orkin SH, Shivdasani RA
Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells. Cell. 2016 Jun 02; 165(6):1389-1400.
Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells.
Cejas P, Li L, O'Neill NK, Duarte M, Rao P, Bowden M, Zhou CW, Mendiola M, Burgos E, Feliu J, Moreno-Rubio J, Guadalajara H, Moreno V, García-Olmo D, Bellmunt J, Mullane S, Hirsch M, Sweeney CJ, Richardson A, Liu XS, Brown M, Shivdasani RA, Long HW
Chromatin immunoprecipitation from fixed clinical tissues reveals tumor-specific enhancer profiles. Nat Med. 2016 06; 22(6):685-91.
Chromatin immunoprecipitation from fixed clinical tissues reveals tumor-specific enhancer profiles.
Zang C, Luyten A, Chen J, Liu XS, Shivdasani RA
NF-E2, FLI1 and RUNX1 collaborate at areas of dynamic chromatin to activate transcription in mature mouse megakaryocytes. Sci Rep. 2016 07 26; 6:30255.
NF-E2, FLI1 and RUNX1 collaborate at areas of dynamic chromatin to activate transcription in mature mouse megakaryocytes.
Sarkar A, Huebner AJ, Sulahian R, Anselmo A, Xu X, Flattery K, Desai N, Sebastian C, Yram MA, Arnold K, Rivera M, Mostoslavsky R, Bronson R, Bass AJ, Sadreyev R, Shivdasani RA, Hochedlinger K
Sox2 Suppresses Gastric Tumorigenesis in Mice. Cell Rep. 2016 08 16; 16(7):1929-41.
Sox2 Suppresses Gastric Tumorigenesis in Mice.
Kim TH, Saadatpour A, Guo G, Saxena M, Cavazza A, Desai N, Jadhav U, Jiang L, Rivera MN, Orkin SH, Yuan GC, Shivdasani RA
Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells. Cell Rep. 2016 08 23; 16(8):2053-2060.
Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells.
Cellular and Molecular Regulation of Thrombopoiesis
Dana Farber/ Harvard Cancer Center SPORE in Gastrointestinal Cancer
Comprehensive Phenotypic Comparison of Normal and Cancer Stem Cells
Anatomic and functional characterization of the intestinal crypt-villus niche
Gene expression in the mammalian intestine
NF E2 AND GLOBIN GENE EXPRESSION AND HEMATOPOIESIS
Transcriptional control of gut epithelial homeostasis and regeneration
Transcriptional control and enhancer recruitment in mouse and human intestinal secretory differentiation
Sulahian R, Chen J, Arany Z, Jadhav U, Peng S, Rustgi AK, Bass AJ, Srivastava A, Hornick JL, Shivdasani RA
SOX15 governs transcription in human stratified epithelia and a subset of esophageal adenocarcinomas. Cell Mol Gastroenterol Hepatol. 2015 Nov 01; 1(6):598-609.e6.
SOX15 governs transcription in human stratified epithelia and a subset of esophageal adenocarcinomas.
Cejas P, Cavazza A, Yandava CN, Moreno V, Horst D, Moreno-Rubio J, Burgos E, Mendiola M, Taing L, Goel A, Feliu J, Shivdasani RA
Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype. Cancer Res. 2017 02 01; 77(3):766-779.
Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype.
Mathur R, Alver BH, San Roman AK, Wilson BG, Wang X, Agoston AT, Park PJ, Shivdasani RA, Roberts CW
ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice. Nat Genet. 2017 Feb; 49(2):296-302.
ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice.
Natural Selection, Crypt Fitness, and Pol III Dependency in the Intestine. Cell Mol Gastroenterol Hepatol. 2016 Nov; 2(6):714-715.
Natural Selection, Crypt Fitness, and Pol III Dependency in the Intestine.
Kacena MA, Shivdasani RA, Wilson K, Xi Y, Troiano N, Nazarian A, Gundberg CM, Bouxsein ML, Lorenzo JA, Horowitz MC
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2. J Bone Miner Res. 2004 Apr; 19(4):652-60.
Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2.
Schulze H, Korpal M, Hurov J, Kim SW, Zhang J, Cantley LC, Graf T, Shivdasani RA
Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. Blood. 2006 May 15; 107(10):3868-75.
Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis.
Zhang J, Rosenthal A, de Sauvage FJ, Shivdasani RA
Downregulation of Hedgehog signaling is required for organogenesis of the small intestine in Xenopus. Dev Biol. 2001 Jan 01; 229(1):188-202.
Downregulation of Hedgehog signaling is required for organogenesis of the small intestine in Xenopus.
Malik TH, Shoichet SA, Latham P, Kroll TG, Peters LL, Shivdasani RA
Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1. EMBO J. 2001 Apr 02; 20(7):1715-25.
Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1.
Characterization of a novel mammalian Groucho isoform and its role in transcriptional regulation. J Biol Chem. 2002 Dec 06; 277(49):47732-40.
Characterization of a novel mammalian Groucho isoform and its role in transcriptional regulation.
Hafler BP, Choi MY, Shivdasani RA, Rowitch DH
Expression and function of Nkx6.3 in vertebrate hindbrain. Brain Res. 2008 Jul 30; 1222:42-50.
Expression and function of Nkx6.3 in vertebrate hindbrain.
Peters LL, Shivdasani RA, Liu SC, Hanspal M, John KM, Gonzalez JM, Brugnara C, Gwynn B, Mohandas N, Alper SL, Orkin SH, Lux SE
Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton. Cell. 1996 Sep 20; 86(6):917-27.
Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton.
Schumacher SE, Shim BY, Corso G, Ryu MH, Kang YK, Roviello F, Saksena G, Peng S, Shivdasani RA, Bass AJ, Beroukhim R
Somatic copy number alterations in gastric adenocarcinomas among Asian and Western patients. PLoS One. 2017; 12(4):e0176045.
Somatic copy number alterations in gastric adenocarcinomas among Asian and Western patients.
Malik TH, Von Stechow D, Bronson RT, Shivdasani RA
Deletion of the GATA domain of TRPS1 causes an absence of facial hair and provides new insights into the bone disorder in inherited tricho-rhino-phalangeal syndromes. Mol Cell Biol. 2002 Dec; 22(24):8592-600.
Deletion of the GATA domain of TRPS1 causes an absence of facial hair and provides new insights into the bone disorder in inherited tricho-rhino-phalangeal syndromes.
de Sauvage FJ, Villeval JL, Shivdasani RA
The Journal of laboratory and clinical medicine
Regulation of megakaryocytopoiesis and platelet production: lessons from animal models. J Lab Clin Med. 1998 Jun; 131(6):496-501.
Regulation of megakaryocytopoiesis and platelet production: lessons from animal models.
The role of transcription factor NF-E2 in megakaryocyte maturation and platelet production. Stem Cells. 1996; 14 Suppl 1:112-5.
The role of transcription factor NF-E2 in megakaryocyte maturation and platelet production.
The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha
Science, another culture: an essay after C. P. Snow. Pharos Alpha Omega Alpha Honor Med Soc. 1989; 52(4):21-4.
Science, another culture: an essay after C. P. Snow.
Lecine P, Villeval JL, Vyas P, Swencki B, Xu Y, Shivdasani RA
Mice lacking transcription factor NF-E2 provide in vivo validation of the proplatelet model of thrombocytopoiesis and show a platelet production defect that is intrinsic to megakaryocytes. Blood. 1998 Sep 01; 92(5):1608-16.
Mice lacking transcription factor NF-E2 provide in vivo validation of the proplatelet model of thrombocytopoiesis and show a platelet production defect that is intrinsic to megakaryocytes.
Molecular regulation of vertebrate early endoderm development. Dev Biol. 2002 Sep 15; 249(2):191-203.
Molecular regulation of vertebrate early endoderm development.
Kulke MH, Demetri GD, Sharpless NE, Ryan DP, Shivdasani R, Clark JS, Spiegelman BM, Kim H, Mayer RJ, Fuchs CS
A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer. Cancer J. 2002 Sep-Oct; 8(5):395-9.
A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer.
Yuan GC, Cai L, Elowitz M, Enver T, Fan G, Guo G, Irizarry R, Kharchenko P, Kim J, Orkin S, Quackenbush J, Saadatpour A, Schroeder T, Shivdasani R, Tirosh I
Challenges and emerging directions in single-cell analysis. Genome Biol. 2017 05 08; 18(1):84.
Challenges and emerging directions in single-cell analysis.
McDevitt MA, Shivdasani RA, Fujiwara Y, Yang H, Orkin SH
A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6781-5.
A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1.
Lee YJ, Swencki B, Shoichet S, Shivdasani RA
A possible role for the high mobility group box transcription factor Tcf-4 in vertebrate gut epithelial cell differentiation. J Biol Chem. 1999 Jan 15; 274(3):1566-72.
A possible role for the high mobility group box transcription factor Tcf-4 in vertebrate gut epithelial cell differentiation.
Overlapping gene expression in fetal mouse intestine development and human colorectal cancer. Cancer Res. 2005 Oct 01; 65(19):8715-22.
Overlapping gene expression in fetal mouse intestine development and human colorectal cancer.
Kim TH, Kim BM, Mao J, Rowan S, Shivdasani RA
Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme. Development. 2011 Aug; 138(15):3225-33.
Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme.
Patel SR, Richardson JL, Schulze H, Kahle E, Galjart N, Drabek K, Shivdasani RA, Hartwig JH, Italiano JE
Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Blood. 2005 Dec 15; 106(13):4076-85.
Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes.
McDevitt MA, Fujiwara Y, Shivdasani RA, Orkin SH
An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):7976-81.
An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice.
Van Dyck F, Braem CV, Chen Z, Declercq J, Deckers R, Kim BM, Ito S, Wu MK, Cohen DE, Dewerchin M, Derua R, Waelkens E, Fiette L, Roebroek A, Schuit F, Van de Ven WJ, Shivdasani RA
Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons. Cell Metab. 2007 Nov; 6(5):406-13.
Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons.
Huang G, Zhang P, Hirai H, Elf S, Yan X, Chen Z, Koschmieder S, Okuno Y, Dayaram T, Growney JD, Shivdasani RA, Gilliland DG, Speck NA, Nimer SD, Tenen DG
PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis. Nat Genet. 2008 Jan; 40(1):51-60.
PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.
Spechler SJ, Merchant JL, Wang TC, Chandrasoma P, Fox JG, Genta RM, Goldenring JR, Hayakawa Y, Kuipers EJ, Lund PK, McKeon F, Mills JC, Odze RD, Peek RM, Pham T, Que J, Rustgi AK, Shaheen NJ, Shivdasani RA, Souza RF, Storz P, Todisco A, Wang DH, Wright NA
A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance. Gastroenterology. 2017 Jul; 153(1):e6-e13.
A Summary of the 2016 James W. Freston Conference of the American Gastroenterological Association: Intestinal Metaplasia in the Esophagus and Stomach: Origins, Differences, Similarities and Significance.
Molecular mechanisms of megakaryocyte differentiation. Semin Thromb Hemost. 2004 Aug; 30(4):389-98.
Molecular mechanisms of megakaryocyte differentiation.
Patel-Hett S, Richardson JL, Schulze H, Drabek K, Isaac NA, Hoffmeister K, Shivdasani RA, Bulinski JC, Galjart N, Hartwig JH, Italiano JE
Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules. Blood. 2008 May 01; 111(9):4605-16.
Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules.
Vyas P, Ault K, Jackson CW, Orkin SH, Shivdasani RA
Consequences of GATA-1 deficiency in megakaryocytes and platelets. Blood. 1999 May 01; 93(9):2867-75.
Consequences of GATA-1 deficiency in megakaryocytes and platelets.
Jadhav U, Saxena M, O'Neill NK, Saadatpour A, Yuan GC, Herbert Z, Murata K, Shivdasani RA
Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells. Cell Stem Cell. 2017 07 06; 21(1):65-77.e5.
Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells.
Genetic evidence that intestinal Notch functions vary regionally and operate through a common mechanism of Math1 repression. J Biol Chem. 2011 Apr 01; 286(13):11427-33.
Genetic evidence that intestinal Notch functions vary regionally and operate through a common mechanism of Math1 repression.
Schulze H, Korpal M, Bergmeier W, Italiano JE, Wahl SM, Shivdasani RA
Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions. Blood. 2004 Dec 15; 104(13):3949-57.
Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions.
Drori S, Girnun GD, Tou L, Szwaya JD, Mueller E, Xia K, Kia X, Shivdasani RA, Spiegelman BM
Hic-5 regulates an epithelial program mediated by PPARgamma. Genes Dev. 2005 Feb 01; 19(3):362-75.
Hic-5 regulates an epithelial program mediated by PPARgamma.
Two roles for Ia in antigen-specific T lymphocyte activation. J Immunol. 1986 Dec 01; 137(11):3393-400.
Two roles for Ia in antigen-specific T lymphocyte activation.
Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ, Orkin SH
Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell. 1995 Jun 02; 81(5):695-704.
Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development.
Lepourcelet M, Tou L, Cai L, Sawada J, Lazar AJ, Glickman JN, Williamson JA, Everett AD, Redston M, Fox EA, Nakatani Y, Shivdasani RA
Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF). Development. 2005 Jan; 132(2):415-27.
Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF).
Choi MY, Romer AI, Hu M, Lepourcelet M, Mechoor A, Yesilaltay A, Krieger M, Gray PA, Shivdasani RA
A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Development. 2006 Oct; 133(20):4119-29.
A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.
Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding. Mol Cell Biol. 2013 Jan; 33(2):281-92.
Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding.
Verzi MP, Shin H, He HH, Sulahian R, Meyer CA, Montgomery RK, Fleet JC, Brown M, Liu XS, Shivdasani RA
Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2. Dev Cell. 2010 Nov 16; 19(5):713-26.
Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2.
Molecular and transcriptional regulation of megakaryocyte differentiation. Stem Cells. 2001; 19(5):397-407.
Molecular and transcriptional regulation of megakaryocyte differentiation.
Italiano JE, Bergmeier W, Tiwari S, Falet H, Hartwig JH, Hoffmeister KM, André P, Wagner DD, Shivdasani RA
Mechanisms and implications of platelet discoid shape. Blood. 2003 Jun 15; 101(12):4789-96.
Mechanisms and implications of platelet discoid shape.
Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells. Gastroenterology. 2008 Aug; 135(2):591-600.
Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells.
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CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature. 2008 Sep 25; 455(7212):547-51.
CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity.
Baba Y, Nosho K, Shima K, Freed E, Irahara N, Philips J, Meyerhardt JA, Hornick JL, Shivdasani RA, Fuchs CS, Ogino S
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Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer. Clin Cancer Res. 2009 Jul 15; 15(14):4665-73.
Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer.
Chan FY, Robinson J, Brownlie A, Shivdasani RA, Donovan A, Brugnara C, Kim J, Lau BC, Witkowska HE, Zon LI
Characterization of adult alpha- and beta-globin genes in the zebrafish. Blood. 1997 Jan 15; 89(2):688-700.
Characterization of adult alpha- and beta-globin genes in the zebrafish.
Characterization of the hematopoietic transcription factor NF-E2 in primary murine megakaryocytes. J Biol Chem. 1998 Mar 27; 273(13):7572-8.
Characterization of the hematopoietic transcription factor NF-E2 in primary murine megakaryocytes.
Ryan DP, Kulke MH, Fuchs CS, Grossbard ML, Grossman SR, Morgan JA, Earle CC, Shivdasani R, Kim H, Mayer RJ, Clark JW
A Phase II study of gemcitabine and docetaxel in patients with metastatic pancreatic carcinoma. Cancer. 2002 Jan 01; 94(1):97-103.
A Phase II study of gemcitabine and docetaxel in patients with metastatic pancreatic carcinoma.
Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases. Mol Cell Biol. 2004 Apr; 24(8):3132-9.
Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases.
Lepourcelet M, Chen YN, France DS, Wang H, Crews P, Petersen F, Bruseo C, Wood AW, Shivdasani RA
Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell. 2004 Jan; 5(1):91-102.
Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex.
Phases of canonical Wnt signaling during the development of mouse intestinal epithelium. Gastroenterology. 2007 Aug; 133(2):529-38.
Phases of canonical Wnt signaling during the development of mouse intestinal epithelium.
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Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH
A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 1997 Jul 01; 16(13):3965-73.
A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development.
Italiano JE, Lecine P, Shivdasani RA, Hartwig JH
Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol. 1999 Dec 13; 147(6):1299-312.
Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes.
Orkin SH, Shivdasani RA, Fujiwara Y, McDevitt MA
Transcription factor GATA-1 in megakaryocyte development. Stem Cells. 1998; 16 Suppl 2:79-83.
Transcription factor GATA-1 in megakaryocyte development.
Junt T, Schulze H, Chen Z, Massberg S, Goerge T, Krueger A, Wagner DD, Graf T, Italiano JE, Shivdasani RA, von Andrian UH
Dynamic visualization of thrombopoiesis within bone marrow. Science. 2007 Sep 21; 317(5845):1767-70.
Dynamic visualization of thrombopoiesis within bone marrow.
Derjuga A, Gourley TS, Holm TM, Heng HH, Shivdasani RA, Ahmed R, Andrews NC, Blank V
Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus. Mol Cell Biol. 2004 Apr; 24(8):3286-94.
Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus.
Ho Sui SJ, Begley K, Reilly D, Chapman B, McGovern R, Rocca-Sera P, Maguire E, Altschuler GM, Hansen TA, Sompallae R, Krivtsov A, Shivdasani RA, Armstrong SA, Culhane AC, Correll M, Sansone SA, Hofmann O, Hide W
The Stem Cell Discovery Engine: an integrated repository and analysis system for cancer stem cell comparisons. Nucleic Acids Res. 2012 Jan; 40(Database issue):D984-91.
The Stem Cell Discovery Engine: an integrated repository and analysis system for cancer stem cell comparisons.
Shivdasani RA, Haluska FG, Dock NL, Dover JS, Kineke EJ, Anderson KC
Brief report: graft-versus-host disease associated with transfusion of blood from unrelated HLA-homozygous donors. N Engl J Med. 1993 Mar 18; 328(11):766-70.
Brief report: graft-versus-host disease associated with transfusion of blood from unrelated HLA-homozygous donors.
The transcriptional control of hematopoiesis. Blood. 1996 May 15; 87(10):4025-39.
The transcriptional control of hematopoiesis.
MicroRNAs: regulators of gene expression and cell differentiation. Blood. 2006 Dec 01; 108(12):3646-53.
MicroRNAs: regulators of gene expression and cell differentiation.
Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3932-7.
Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells.
Takada K, Zhu D, Bird GH, Sukhdeo K, Zhao JJ, Mani M, Lemieux M, Carrasco DE, Ryan J, Horst D, Fulciniti M, Munshi NC, Xu W, Kung AL, Shivdasani RA, Walensky LD, Carrasco DR
Targeted disruption of the BCL9/ß-catenin complex inhibits oncogenic Wnt signaling. Sci Transl Med. 2012 Aug 22; 4(148):148ra117.
Targeted disruption of the BCL9/ß-catenin complex inhibits oncogenic Wnt signaling.
Kulke MH, Freed E, Chiang D, Philips J, Zahrieh D, Glickman JN, Shivdasani RA
High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss. Genes Chrom Cancer. 2008; 47:591-603.
High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss
Schulze H, Dose M, Korpal M, Meyer I, Italiano JE, Shivdasani RA
RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. J Biol Chem. 2008 May 16; 283(20):14109-19.
RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules.
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Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. Br J Cancer. 2009 Aug 04; 101(3):465-72.
Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer.
GEFs on the RhoAd to a colossal nucleus. Dev Cell. 2012 Mar 13; 22(3):471-2.
GEFs on the RhoAd to a colossal nucleus.
Transfusion-associated graft-versus-host disease: scratching the surface. Transfusion. 1993 Sep; 33(9):696-7.
Transfusion-associated graft-versus-host disease: scratching the surface.
Saxena M, Roman AKS, O'Neill NK, Sulahian R, Jadhav U, Shivdasani RA
Transcription factor-dependent 'anti-repressive' mammalian enhancers exclude H3K27me3 from extended genomic domains. Genes Dev. 2017 12 01; 31(23-24):2391-2404.
Transcription factor-dependent 'anti-repressive' mammalian enhancers exclude H3K27me3 from extended genomic domains.
Gastric epithelial stem cells. Gastroenterology. 2011 Feb; 140(2):412-24.
Verzi MP, Stanfel MN, Moses KA, Kim BM, Zhang Y, Schwartz RJ, Shivdasani RA, Zimmer WE
Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development. Gastroenterology. 2009 May; 136(5):1701-10.
Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development.
Hematology/oncology clinics of North America
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Deveaux S, Cohen-Kaminsky S, Shivdasani RA, Andrews NC, Filipe A, Kuzniak I, Orkin SH, Roméo PH, Mignotte V
p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes. EMBO J. 1997 Sep 15; 16(18):5654-61.
p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes.
Levin J, Peng JP, Baker GR, Villeval JL, Lecine P, Burstein SA, Shivdasani RA
Pathophysiology of thrombocytopenia and anemia in mice lacking transcription factor NF-E2. Blood. 1999 Nov 01; 94(9):3037-47.
Pathophysiology of thrombocytopenia and anemia in mice lacking transcription factor NF-E2.
Poy F, Lepourcelet M, Shivdasani RA, Eck MJ
Structure of a human Tcf4-beta-catenin complex. Nat Struct Biol. 2001 Dec; 8(12):1053-7.
Structure of a human Tcf4-beta-catenin complex.
Martin F, van Deursen JM, Shivdasani RA, Jackson CW, Troutman AG, Ney PA
Erythroid maturation and globin gene expression in mice with combined deficiency of NF-E2 and nrf-2. Blood. 1998 May 01; 91(9):3459-66.
Erythroid maturation and globin gene expression in mice with combined deficiency of NF-E2 and nrf-2.
Lobo GP, Amengual J, Baus D, Shivdasani RA, Taylor D, von Lintig J
Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX. J Biol Chem. 2013 Mar 29; 288(13):9017-27.
Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX.
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Culture and in vitro differentiation of murine megakaryocytes. In: Coligan JE, Bierer BE, Margulies DH, Shevach EM, Strober W, editors. Current protocols in immunology. 2005; Chapter 22F:6.1-6.13.
Culture and in vitro differentiation of murine megakaryocytes
Lecine P, Italiano JE, Kim SW, Villeval JL, Shivdasani RA
Hematopoietic-specific beta 1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2. Blood. 2000 Aug 15; 96(4):1366-73.
Hematopoietic-specific beta 1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2.
Toward mechanism-based cancer care. JAMA. 2001 Feb 07; 285(5):588-93.
Malhotra N, Leyva-Castillo JM, Jadhav U, Barreiro O, Kam C, O'Neill NK, Meylan F, Chambon P, von Andrian UH, Siegel RM, Wang EC, Shivdasani R, Geha RS
RORa-expressing T regulatory cells restrain allergic skin inflammation. Sci Immunol. 2018 03 02; 3(21).
RORa-expressing T regulatory cells restrain allergic skin inflammation.