DI4DanielIrimiaDaniel Irimia, M.D., Ph.D.42.37904200000000-71.0514810000000011972Irimia, DanielI am passionate about understanding how neutrophils contribute to health and disease. Neutrophils are the largest white blood cell population in the blood (in humans, 60% of white blood cells are neutrophils). Neutrophils are mentioned daily by physicians and the neutrophil absolute count is one of the most common blood tests prescribed for evaluating patient defenses against microbes. However, new discoveries are changing the paradigm of neutrophil functions. Enabled by novel technologies to study neutrophils ex vivo, new assays are emerging to study the contribution of human neutrophils to the pathology of numerous diseases:
(1) The traffic of neutrophils is traditionally considered to be unidirectional, from the blood to the tissue, guided by chemoattractant gradients (after which neutrophils die and are removed by macrophages). Using inflammation-on-a-chip devices, we showed for the first time that human neutrophils continue migrating persistently after reaching the highest chemoattractant concentration and all (100%) can be directed back to the starting location. Reports in zebrafish and mice confirmed that neutrophils are capable of reversing migration from tissues to circulation. These findings establish the fundamental basis for testing the functionality of neutrophils in blood and designing novel assays to diagnose and monitor inflammations, infections, and sepsis.
(2) Neutrophils often interact with common pathogens that are larger than what one neutrophil could phagocytose (e.g. clusters of bacteria – S.aureus or S.pyogenes, elongated hyphae of filamentous fungi – Candida and Aspergillus). During these interactions, a novel behavior can be observed, where neutrophils cooperate against targets (a process named swarming). We designed the first high-throughput platform for the systematic study of human neutrophil swarming ex vivo (Reategui et al, Nat Bio Eng, 2016). We leveraged this platform to uncover a complex constellation of mediators that coordinate the activity of multiple neutrophils against large targets and mediate their interactions with leukocytes and non-immune cells, effectively placing the neutrophils at the center of immune responses.
(3) Neutrophils can release chromatin to trap microbes (neutrophil extracellular traps - NETs). Originally, NETs were proposed to play antimicrobial functions. This paradigm is shifting, following the discovery of biochemical properties responsible for complications in autoimmune diseases, diabetes, and cancer. Our contribution to this paradigm shift is the design of devices to test the mechanical role for the chromatin fibers encompassing the NETs, during inflammation and sepsis (Boneshaker et al, Int. Bio, 2016). Our findings challenge the traditional view of capillary plexuses providing robust delivery of oxygen to tissues. On the contrary, we determined that capillary plexuses are vulnerable to neutrophils and NETs, which can completely disrupt their normal function, triggering hypoxia and leading to organ failure during infections and sepsis.
od.617/724-6543Associate Professor of Surgerycatalyst:eCommonsLogineCommons Loginplugins:FeaturedVideosFeatured Videosplugins:TwitterTwitterprns:awardConferredByaward conferred byprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:mediaLinksmedia linksprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborProfilesRNS Plugin Instanceprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipvivo:awardOrHonorawards and honorsAward or Honor ReceiptDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkAnchorTextlink anchor textvivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:overviewoverviewvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleURLLinkrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 1050929229526009Wang X, Irimia DMethods in molecular biology (Clifton, N.J.)Neutrophil Chemotaxis in One Droplet of Blood Using Microfluidic Assays. Methods Mol Biol. 2018; 1749:351-360.Methods Mol Biol2018-01-01T00:00:002018Neutrophil Chemotaxis in One Droplet of Blood Using Microfluidic Assays.20023765Irimia D, Toner MIntegrative biology : quantitative biosciences from nano to macroSpontaneous migration of cancer cells under conditions of mechanical confinement. Integr Biol (Camb). 2009 Sep; 1(8-9):506-12.Integr Biol (Camb)2009-07-16T00:00:002009Spontaneous migration of cancer cells under conditions of mechanical confinement.Authorship 1063253129728272Irimia D, Wang XTrends in biotechnologyInflammation-on-a-Chip: Probing the Immune System Ex Vivo. Trends Biotechnol. 2018 09; 36(9):923-937.Trends Biotechnol2018-05-01T00:00:002018Inflammation-on-a-Chip: Probing the Immune System Ex Vivo.29733334DeVos SL, Corjuc BT, Commins C, Dujardin S, Bannon RN, Corjuc D, Moore BD, Bennett RE, Jorfi M, Gonzales JA, Dooley PM, Roe AD, Pitstick R, Irimia D, Frosch MP, Carlson GA, Hyman BTBrain : a journal of neurologyTau reduction in the presence of amyloid-ß prevents tau pathology and neuronal death in vivo. Brain. 2018 07 01; 141(7):2194-2212.Brain2018-07-01T00:00:002018Tau reduction in the presence of amyloid-ß prevents tau pathology and neuronal death in vivo.17180208King KR, Wang S, Irimia D, Jayaraman A, Toner M, Yarmush MLLab on a chipA high-throughput microfluidic real-time gene expression living cell array. Lab Chip. 2007 Jan; 7(1):77-85.Lab Chip2006-09-29T00:00:002006A high-throughput microfluidic real-time gene expression living cell array.17538717Cheng X, Liu YS, Irimia D, Demirci U, Yang L, Zamir L, Rodríguez WR, Toner M, Bashir RLab on a chipCell detection and counting through cell lysate impedance spectroscopy in microfluidic devices. Lab Chip. 2007 Jun; 7(6):746-55.Lab Chip2007-05-11T00:00:002007Cell detection and counting through cell lysate impedance spectroscopy in microfluidic devices.Authorship 10658747Authorship 10642701429770423Kim JJ, Reátegui E, Hopke A, Jalali F, Roushan M, Doyle PS, Irimia DLab on a chipLarge-scale patterning of living colloids for dynamic studies of neutrophil-microbe interactions. Lab Chip. 2018 05 29; 18(11):1514-1520.Lab Chip2018-05-29T00:00:002018Large-scale patterning of living colloids for dynamic studies of neutrophil-microbe interactions.18651066Edd JF, Di Carlo D, Humphry KJ, Köster S, Irimia D, Weitz DA, Toner MLab on a chipControlled encapsulation of single-cells into monodisperse picolitre drops. Lab Chip. 2008 Aug; 8(8):1262-4.Lab Chip2008-06-13T00:00:002008Controlled encapsulation of single-cells into monodisperse picolitre drops.20607869Kane BJ, Younan G, Helm D, Dastouri P, Prentice-Mott H, Irimia D, Chan RK, Toner M, Orgill DPJournal of biomedical materials research. Part AControlled induction of distributed microdeformation in wounded tissue via a microchamber array dressing. J Biomed Mater Res A. 2010 Nov; 95(2):333-40.J Biomed Mater Res A2010-11-01T00:00:002010Controlled induction of distributed microdeformation in wounded tissue via a microchamber array dressing.Authorship 10702581229808244Raymond SL, Hawkins RB, Murphy TJ, Rincon JC, Stortz JA, López MC, Ungaro R, Ellett F, Baker HV, Wynn JL, Moldawer LL, Irimia D, Larson SDJournal of molecular medicine (Berlin, Germany)Impact of toll-like receptor 4 stimulation on human neonatal neutrophil spontaneous migration, transcriptomics, and cytokine production. J Mol Med (Berl). 2018 07; 96(7):673-684.J Mol Med (Berl)2018-05-28T00:00:002018Impact of toll-like receptor 4 stimulation on human neonatal neutrophil spontaneous migration, transcriptomics, and cytokine production.21348958Rosenbach AE, Koria P, Goverman J, Kotz KT, Gupta A, Yu M, Fagan SP, Irimia D, Tompkins RGClinical and translational scienceMicrofluidics for T- lymphocyte cell separation and inflammation monitoring in burn patients. Clin Transl Sci. 2011 Feb; 4(1):63-8.Clin Transl Sci2011-02-01T00:00:002011Microfluidics for T- lymphocyte cell separation and inflammation monitoring in burn patients.23185003Jones CN, Dalli J, Dimisko L, Wong E, Serhan CN, Irimia DProceedings of the National Academy of Sciences of the United States of AmericaMicrofluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):20560-5.Proc Natl Acad Sci U S A2012-11-26T00:00:002012Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions.Authorship 108411318275222Di Carlo D, Edd JF, Irimia D, Tompkins RG, Toner MAnalytical chemistryEquilibrium separation and filtration of particles using differential inertial focusing. Anal Chem. 2008 Mar 15; 80(6):2204-11.Anal Chem2008-02-15T00:00:002008Equilibrium separation and filtration of particles using differential inertial focusing.20930119Stott SL, Hsu CH, Tsukrov DI, Yu M, Miyamoto DT, Waltman BA, Rothenberg SM, Shah AM, Smas ME, Korir GK, Floyd FP, Gilman AJ, Lord JB, Winokur D, Springer S, Irimia D, Nagrath S, Sequist LV, Lee RJ, Isselbacher KJ, Maheswaran S, Haber DA, Toner MProceedings of the National Academy of Sciences of the United States of AmericaIsolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43):18392-7.Proc Natl Acad Sci U S A2010-10-07T00:00:002010Isolation of circulating tumor cells using a microvortex-generating herringbone-chip.23028729Xu C, Poh YK, Roes I, O'Cearbhaill ED, Matthiesen ME, Mu L, Yang SY, Miranda-Nieves D, Irimia D, Karp JMPloS oneA portable chemotaxis platform for short and long term analysis. PLoS One. 2012; 7(9):e44995.PLoS One2012-09-17T00:00:002012A portable chemotaxis platform for short and long term analysis.23430978Kurihara T, Jones CN, Yu YM, Fischman AJ, Watada S, Tompkins RG, Fagan SP, Irimia DFASEB journal : official publication of the Federation of American Societies for Experimental BiologyResolvin D2 restores neutrophil directionality and improves survival after burns. FASEB J. 2013 Jun; 27(6):2270-81.FASEB J2013-02-21T00:00:002013Resolvin D2 restores neutrophil directionality and improves survival after burns.Daniel IrimiaPneumatic Valves in Encyclopedia of Micro- and Nanofluidics
edited by Li, DongqingPneumatic Valves in Encyclopedia of Micro- and Nanofluidics
edited by Li, Dongqing. 2006.2006-12-01T00:00:002006Pneumatic Valves in Encyclopedia of Micro- and Nanofluidics
edited by Li, DongqingAuthorship 108533221Authorship 1085333Lab on a Chip, Corning Incorporated, and the Chemical and Biological Microsystems Society (CBMS)2016Pioneers of Miniaturisation PrizeEllett F, Jorgensen J, Marand AL, Liu YM, Martinez MM, Sein V, Butler KL, Lee J, Irimia DNature Biomedical Engineering Diagnosis of sepsis from a drop of blood by measurement of spontaneous neutrophil motility in a microfluidic assay. Nature Biomedical Engineering. 2018; 2(2):207–214.2018-08-06T00:00:002018Diagnosis of sepsis from a drop of blood by measurement of spontaneous neutrophil motility in a microfluidic assay30076281Krishnamoorthy N, Douda DN, Brüggemann TR, Ricklefs I, Duvall MG, Abdulnour RE, Martinod K, Tavares L, Wang X, Cernadas M, Israel E, Mauger DT, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Wenzel S, Dunican E, Fahy JV, Irimia D, Wagner DD, Levy BDScience immunologyNeutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma. Sci Immunol. 2018 08 03; 3(26).Sci Immunol2018-08-03T00:00:002018Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma.Authorship 1089599730129679Wang X, Jodoin E, Jorgensen J, Lee J, Markmann JJ, Cataltepe S, Irimia DJournal of leukocyte biologyProgressive mechanical confinement of chemotactic neutrophils induces arrest, oscillations, and retrotaxis. J Leukoc Biol. 2018 12; 104(6):1253-1261.J Leukoc Biol2018-08-21T00:00:002018Progressive mechanical confinement of chemotactic neutrophils induces arrest, oscillations, and retrotaxis.19532960Edd JF, Humphry KJ, Irimia D, Weitz DA, Toner MLab on a chipNucleation and solidification in static arrays of monodisperse drops. Lab Chip. 2009 Jul 07; 9(13):1859-65.Lab Chip2009-04-03T00:00:002009Nucleation and solidification in static arrays of monodisperse drops.22314635Scherber C, Aranyosi AJ, Kulemann B, Thayer SP, Toner M, Iliopoulos O, Irimia DIntegrative biology : quantitative biosciences from nano to macroEpithelial cell guidance by self-generated EGF gradients. Integr Biol (Camb). 2012 Mar; 4(3):259-69.Integr Biol (Camb)2012-02-08T00:00:002012Epithelial cell guidance by self-generated EGF gradients.Authorship 1090488430165965Muldur S, Marand AL, Ellett F, Irimia DMethods in cell biologyMeasuring spontaneous neutrophil motility signatures from a drop of blood using microfluidics. Methods Cell Biol. 2018; 147:93-107.Methods Cell Biol2018-08-18T00:00:002018Measuring spontaneous neutrophil motility signatures from a drop of blood using microfluidics.20126692Chen C, Skog J, Hsu CH, Lessard RT, Balaj L, Wurdinger T, Carter BS, Breakefield XO, Toner M, Irimia DLab on a chipMicrofluidic isolation and transcriptome analysis of serum microvesicles. Lab Chip. 2010 Feb 21; 10(4):505-11.Lab Chip2009-12-08T00:00:002009Microfluidic isolation and transcriptome analysis of serum microvesicles.22174129Aldridge BB, Fernandez-Suarez M, Heller D, Ambravaneswaran V, Irimia D, Toner M, Fortune SMScience (New York, N.Y.)Asymmetry and aging of mycobacterial cells lead to variable growth and antibiotic susceptibility. Science. 2012 Jan 06; 335(6064):100-4.Science2011-12-15T00:00:002011Asymmetry and aging of mycobacterial cells lead to variable growth and antibiotic susceptibility.Authorship 1096998930283724Ellett F, Jorgensen J, Marand AL, Liu YM, Martinez MM, Sein V, Butler KL, Lee J, Irimia DNature biomedical engineeringDiagnosis of sepsis from a drop of blood by measurement of spontaneous neutrophil motility in a microfluidic assay. Nat Biomed Eng. 2018 Apr; 2(4):207-214.Nat Biomed Eng2018-03-19T00:00:002018Diagnosis of sepsis from a drop of blood by measurement of spontaneous neutrophil motility in a microfluidic assay.15481964Irimia D, Tompkins RG, Toner MAnalytical chemistrySingle-cell chemical lysis in picoliter-scale closed volumes using a microfabricated device. Anal Chem. 2004 Oct 15; 76(20):6137-43.Anal Chem2004-10-15T00:00:002004Single-cell chemical lysis in picoliter-scale closed volumes using a microfabricated device.18025477Di Carlo D, Irimia D, Tompkins RG, Toner MProceedings of the National Academy of Sciences of the United States of AmericaContinuous inertial focusing, ordering, and separation of particles in microchannels. Proc Natl Acad Sci U S A. 2007 Nov 27; 104(48):18892-7.Proc Natl Acad Sci U S A2007-11-19T00:00:002007Continuous inertial focusing, ordering, and separation of particles in microchannels.18467031Parekkadan B, Berdichevsky Y, Irimia D, Leeder A, Yarmush G, Toner M, Levine JB, Yarmush MLNeuroscience lettersCell-cell interaction modulates neuroectodermal specification of embryonic stem cells. Neurosci Lett. 2008 Jun 20; 438(2):190-5.Neurosci Lett2008-04-11T00:00:002008Cell-cell interaction modulates neuroectodermal specification of embryonic stem cells.Authorship 10998611330300408Raymond SL, Hawkins RB, Stortz JA, Murphy TJ, Ungaro R, Dirain ML, Nacionales DC, Hollen MK, Rincon JC, Larson SD, Brakenridge SC, Moore FA, Irimia D, Efron PA, Moldawer LLPloS oneSepsis is associated with reduced spontaneous neutrophil migration velocity in human adults. PLoS One. 2018; 13(10):e0205327.PLoS One2018-10-09T00:00:002018Sepsis is associated with reduced spontaneous neutrophil migration velocity in human adults.20450351Irimia DAnnual review of biomedical engineeringMicrofluidic technologies for temporal perturbations of chemotaxis. Annu Rev Biomed Eng. 2010 Aug 15; 12:259-84.Annu Rev Biomed Eng2010-08-15T00:00:002010Microfluidic technologies for temporal perturbations of chemotaxis.Authorship 1114227630451882Otawara M, Roushan M, Wang X, Ellett F, Yu YM, Irimia DScientific reportsMicrofluidic Assay Measures Increased Neutrophil Extracellular Traps Circulating in Blood after Burn Injuries. Sci Rep. 2018 11 19; 8(1):16983.Sci Rep2018-11-19T00:00:002018Microfluidic Assay Measures Increased Neutrophil Extracellular Traps Circulating in Blood after Burn Injuries.Daniel IrimiaTechniques of Manipulating Cells in Encyclopedia of Micro- and Nanofluidics
edited by Li, DongqingTechniques of Manipulating Cells in Encyclopedia of Micro- and Nanofluidics
edited by Li, Dongqing. 2006.2006-12-01T00:00:002006Techniques of Manipulating Cells in Encyclopedia of Micro- and Nanofluidics
edited by Li, Dongqing18327641Prabhakarpandian B, Pant K, Scott RC, Pattillo CB, Patillo CB, Irimia D, Kiani MF, Sundaram SBiomedical microdevicesSynthetic microvascular networks for quantitative analysis of particle adhesion. Biomed Microdevices. 2008 Aug; 10(4):585-95.Biomed Microdevices2008-08-01T00:00:002008Synthetic microvascular networks for quantitative analysis of particle adhesion.Authorship 1101002d__irimia The surprising abilities of human neutrophils to squeeze through narrow spaces Human neutrophils racing through a maze Human neutrophil chemotaxis directly from a droplet of blood The surprising abilities of human neutrophils to squeeze through narrow spaces Human neutrophils racing through a maze Human neutrophil chemotaxis directly from a droplet of blood Neutrophils go left, right, left, right at bifurcations The surprising abilities of human neutrophils to squeeze through narrow spaces Human neutrophils racing through a maze Neutrophils go left, right, left, right at bifurcations Human neutrophil chemotaxis directly from a droplet of blood The surprising abilities of human neutrophils to squeeze through narrow spaces Neutrophils go left, right, left, right at bifurcations Human neutrophils racing through a maze Human neutrophil chemotaxis directly from a droplet of blood Neutrophils go left, right, left, right at bifurcations The surprising abilities of human neutrophils to squeeze through narrow spaces Human neutrophils racing through a maze Human neutrophil chemotaxis directly from a droplet of blood Neutrophils go left, right, left, right at bifurcations The surprising abilities of human neutrophils to squeeze through narrow spaces Human neutrophils racing through a maze Human neutrophil chemotaxis directly from a droplet of blood Neutrophil swarming blocks the growth of Candida Neutrophils go left, right, left, right at bifurcations The surprising abilities of human neutrophils to squeeze through narrow spaces Human neutrophils racing through a maze Neutrophil swarming blocks the growth of Candida Human neutrophil chemotaxis directly from a droplet of blood Neutrophils go left, right, left, right at bifurcations The surprising abilities of human neutrophils to squeeze through narrow spaces Neutrophil swarming blocks the growth of Candida Human neutrophils racing through a maze Human neutrophil chemotaxis directly from a droplet of blood12/09/2014http://www.eurekalert.org/pub_releases/2014-12/mgh-amo120514.phpPredicting sepsis in patients with major burns03/10/2014http://www.wsj.com/articles/SB10001424052702304450904579369372368336300Bioengineer Builds Microscopic Racetrack for Cells' Competition05/30/2013http://www.eurekalert.org/pub_releases/2013-05/foas-ndp053013.phpRapid diagnosis and treatment of sepsis05/07/2014http://www.nature.com/news/the-game-is-on-1.15167Amoeba races demonstrate a fun way to promote interest in science23684304Mantel PY, Hoang AN, Goldowitz I, Potashnikova D, Hamza B, Vorobjev I, Ghiran I, Toner M, Irimia D, Ivanov AR, Barteneva N, Marti MCell host & microbeMalaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system. Cell Host Microbe. 2013 May 15; 13(5):521-534.Cell Host Microbe2013-05-15T00:00:002013Malaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system.Authorship 1134883830865740Ellett F, Jalali F, Marand AL, Jorgensen J, Mutlu BR, Lee J, Raff AB, Irimia DLab on a chipMicrofluidic arenas for war games between neutrophils and microbes. Lab Chip. 2019 03 27; 19(7):1205-1216.Lab Chip2019-03-27T00:00:002019Microfluidic arenas for war games between neutrophils and microbes.D002634Physiology2926750.773477Chemotaxis, LeukocyteD002633Physiology3596020.767835ChemotaxisD046210DevicesProcedures3008270.593214Microfluidic Analytical TechniquesD009504Anatomy126836980.398241NeutrophilsD044085Occupations2626600.648226MicrofluidicsAuthorship 114858110Authorship 11490261131014479Tsai TY, Collins SR, Chan CK, Hadjitheodorou A, Lam PY, Lou SS, Yang HW, Jorgensen J, Ellett F, Irimia D, Davidson MW, Fischer RS, Huttenlocher A, Meyer T, Ferrell JE, Theriot JADevelopmental cellEfficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization. Dev Cell. 2019 04 22; 49(2):189-205.e6.Dev Cell2019-04-22T00:00:002019Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization.31024528Jones CN, Ellett F, Robertson AL, Forrest KM, Judice K, Balkovec JM, Springer M, Markmann JF, Vyas JM, Warren HS, Irimia DFrontiers in immunologyBifunctional Small Molecules Enhance Neutrophil Activities Against Aspergillus fumigatus in vivo and in vitro. Front Immunol. 2019; 10:644.Front Immunol2019-04-09T00:00:002019Bifunctional Small Molecules Enhance Neutrophil Activities Against Aspergillus fumigatus in vivo and in vitro.AnaesthesiaMedicineNeurologyPediatricsSurgeryInfectious DiseaseRenalBrigham and Women's HospitalBoston Children's HospitalMassachusetts General HospitalMAS9MichaelSchwarzschildMichael A. Schwarzschild, M.D., Ph.D.42.37904200000000-71.0514810000000019322Schwarzschild, MichaelJulieanne Dorn Professor of NeurologyMKM13MichaelMansourMichael Karim Mansour, M.D., Ph.D.42.36241700000000-71.0689370000000072954Mansour, MichaelAssociate Professor of MedicineLY36LaelYonkerLael Yonker, M.D.42.36126580000000-71.0651591000000046835Yonker, LaelAssistant Professor of PediatricsCNS3CharlesSerhanCharles Nicholas Serhan, Ph.D.42.33510370000000-71.1061649000000017417Serhan, CharlesSimon Gelman Professor of AnaesthesiaDEI1DonIngberDon Ingber, M.D.,Ph.D.42.33773240000000-71.1051962000000029942Ingber, DonJudah Folkman Professor of Vascular Biology in the Department of Surgery11194selected publications10.0380.00446301620research areas9.236820.0178618144coauthor of188.66822.687359similar toUtkanDemirciUtkan Demirci, Ph.D.42.36070000000000-71.100900000000004426Demirci, UtkanVisiting Professor of MedicineOBU1OsmanUstaOsman Berk Usta, Ph.D.42.37904200000000-71.0514810000000056560Usta, OsmanAssociate Professor of SurgeryKBK1KimberlyKegelKimberly B. Kegel, Ph.D.42.37904200000000-71.0514810000000088115Kegel, KimberlyAssistant Professor of NeurologyKPL8KyleLillisKyle Patrick Lillis, Ph.D.42.37904200000000-71.0514810000000015860Lillis, KyleAssistant Professor of NeurologyMT2MehmetTonerMehmet Toner, Ph.D.42.37904200000000-71.051481000000003525Toner, MehmetHelen Andrus Benedict Professor of SurgeryAuthorship 1160267931223642Roushan M, Jorfi M, Mishra A, Wong KHK, Jorgensen J, Ell E, Markmann JF, Lee J, Irimia DAdvanced biosystemsTrapped Chromatin Fibers Damage Flowing Red Blood Cells. Adv Biosyst. 2018 Oct; 2(10).Adv Biosyst2018-08-12T00:00:002018Trapped Chromatin Fibers Damage Flowing Red Blood Cells.Authorship 1376772Authorship 1181070631423506Kim JJ, Ellett F, Thomas CN, Jalali F, Anderson RR, Irimia D, Raff ABLab on a chipA microscale, full-thickness, human skin on a chip assay simulating neutrophil responses to skin infection and antibiotic treatments. Lab Chip. 2019 09 10; 19(18):3094-3103.Lab Chip2019-09-10T00:00:002019A microscale, full-thickness, human skin on a chip assay simulating neutrophil responses to skin infection and antibiotic treatments.Authorship 1198527431611872Park J, Baik SH, Mook-Jung I, Irimia D, Cho HFrontiers in immunologyMimicry of Central-Peripheral Immunity in Alzheimer's Disease and Discovery of Neurodegenerative Roles in Neutrophil. Front Immunol. 2019; 10:2231.Front Immunol2019-09-25T00:00:002019Mimicry of Central-Peripheral Immunity in Alzheimer's Disease and Discovery of Neurodegenerative Roles in Neutrophil.Authorship 1204516231728986Hopke A, Irimia DMethods in molecular biology (Clifton, N.J.)Ex Vivo Human Neutrophil Swarming Against Live Microbial Targets. Methods Mol Biol. 2020; 2087:107-116.Methods Mol Biol2020-01-01T00:00:002020Ex Vivo Human Neutrophil Swarming Against Live Microbial Targets.true1Julieanne Dorn Professor of NeurologyJulieanne Dorn Professor of Neurologytrue1Associate Professor of SurgeryAssociate Professor of Surgerytrue1Simon Gelman Professor of AnaesthesiaSimon Gelman Professor of Anaesthesiatrue1Assistant Professor of PediatricsAssistant Professor of PediatricsAuthorship 1260953Authorship 1209783131811267Irimia DNature biomedical engineeringAssaying leukocyte hallmarks during sepsis. Nat Biomed Eng. 2019 12; 3(12):947-948.Nat Biomed Eng2019-12-01T00:00:002019Assaying leukocyte hallmarks during sepsis.Authorship 12128188Authorship 1210383631832320Wang X, Scarfò I, Schmidts A, Toner M, Maus MV, Irimia DAdvanced science (Weinheim, Baden-Wurttemberg, Germany)Dynamic Profiling of Antitumor Activity of CAR T Cells Using Micropatterned Tumor Arrays. Adv Sci (Weinh). 2019 Dec; 6(23):1901829.Adv Sci (Weinh)2019-09-30T00:00:002019Dynamic Profiling of Antitumor Activity of CAR T Cells Using Micropatterned Tumor Arrays.31856088Park JK, Hank T, Scherber CM, Lillemoe KD, Fernández-Del Castillo C, Warshaw AL, Toner M, Irimia D, Thayer SP, Liss ASPancreasPrimary and Metastatic Pancreatic Cancer Cells Exhibit Differential Migratory Potentials. Pancreas. 2020 01; 49(1):128-134.Pancreas2020-01-01T00:00:002020Primary and Metastatic Pancreatic Cancer Cells Exhibit Differential Migratory Potentials.true1Professor of MedicineProfessor of MedicineAuthorship 1317371Authorship 1231673832165642Frydman GH, Tessier SN, Wong KHK, Vanderburg CR, Fox JG, Toner M, Tompkins RG, Irimia DScientific reportsMegakaryocytes contain extranuclear histones and may be a source of platelet-associated histones during sepsis. Sci Rep. 2020 03 12; 10(1):4621.Sci Rep2020-03-12T00:00:002020Megakaryocytes contain extranuclear histones and may be a source of platelet-associated histones during sepsis.Authorship 1724207Authorship 1243807832341348Hopke A, Scherer A, Kreuzburg S, Abers MS, Zerbe CS, Dinauer MC, Mansour MK, Irimia DNature communicationsNeutrophil swarming delays the growth of clusters of pathogenic fungi. Nat Commun. 2020 04 27; 11(1):2031.Nat Commun2020-04-27T00:00:002020Neutrophil swarming delays the growth of clusters of pathogenic fungi.Authorship 1740242true1Instructor in SurgeryInstructor in SurgeryAuthorship 124789319Authorship 12484658Authorship 1248432532404937Wang X, Hossain M, Bogoslowski A, Kubes P, Irimia DNature communicationsChemotaxing neutrophils enter alternate branches at capillary bifurcations. Nat Commun. 2020 05 13; 11(1):2385.Nat Commun2020-05-13T00:00:002020Chemotaxing neutrophils enter alternate branches at capillary bifurcations.32409681Hopke A, Scherer A, Kreuzburg S, Abers MS, Zerbe CS, Dinauer MC, Mansour MK, Irimia DNature communicationsPublisher Correction: Neutrophil swarming delays the growth of clusters of pathogenic fungi. Nat Commun. 2020 05 14; 11(1):2492.Nat Commun2020-05-14T00:00:002020Publisher Correction: Neutrophil swarming delays the growth of clusters of pathogenic fungi.32398316Negoro PE, Xu S, Dagher Z, Hopke A, Reedy JL, Feldman MB, Khan NS, Viens AL, Alexander NJ, Atallah NJ, Scherer AK, Dutko RA, Jeffery J, Kernien JF, Fites JS, Nett JE, Klein BS, Vyas JM, Irimia D, Sykes DB, Mansour MKmBioSpleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to Candida Species. mBio. 2020 05 12; 11(3).mBio2020-05-12T00:00:002020Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to Candida Species.Authorship 1303002Authorship 6307469Authorship 6307479Authorship 630748423663851Desai SP, Bhatia SN, Toner M, Irimia DBiophysical journalMitochondrial localization and the persistent migration of epithelial cancer cells. Biophys J. 2013 May 07; 104(9):2077-88.Biophys J2013-05-07T00:00:002013Mitochondrial localization and the persistent migration of epithelial cancer cells.23665843Cho H, Hashimoto T, Wong E, Hori Y, Wood LB, Zhao L, Haigis KM, Hyman BT, Irimia DScientific reportsMicrofluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-ß on microglial accumulation. Sci Rep. 2013; 3:1823.Sci Rep2013-01-01T00:00:002013Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-ß on microglial accumulation.32827525Yonker LM, Neilan AM, Bartsch Y, Patel AB, Regan J, Arya P, Gootkind E, Park G, Hardcastle M, St John A, Appleman L, Chiu ML, Fialkowski A, De la Flor D, Lima R, Bordt EA, Yockey LJ, D'Avino P, Fischinger S, Shui JE, Lerou PH, Bonventre JV, Yu XG, Ryan ET, Bassett IV, Irimia D, Edlow AG, Alter G, Li JZ, Fasano AThe Journal of pediatricsPediatric Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Clinical Presentation, Infectivity, and Immune Responses. J Pediatr. 2020 12; 227:45-52.e5.J Pediatr2020-08-20T00:00:002020Pediatric Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Clinical Presentation, Infectivity, and Immune Responses.Authorship 127989726Authorship 12804541532853820Alexander NJ, Bozym DJ, Farmer JR, Parris P, Viens A, Atallah N, Hopke A, Scherer A, Dagher Z, Barros N, Knooihuizen SAI, Saff RR, Pasternack MS, Thompson RW, Irimia D, Mansour MKThe journal of allergy and clinical immunology. In practiceNeutrophil functional profiling and cytokine augmentation for patients with multiple recurrent infections: A case study. J Allergy Clin Immunol Pract. 2021 02; 9(2):986-988.J Allergy Clin Immunol Pract2020-08-24T00:00:002020Neutrophil functional profiling and cytokine augmentation for patients with multiple recurrent infections: A case study.Authorship 129004826Authorship 12904222632956696Yonker LM, Neilan AM, Bartsch Y, Patel AB, Regan J, Arya P, Gootkind E, Park G, Hardcastle M, St John A, Appleman L, Chiu ML, Fialkowski A, De la Flor D, Lima R, Bordt EA, Yockey LJ, D'Avino P, Fischinger S, Shui JE, Lerou PH, Bonventre JV, Yu XG, Ryan ET, Bassett IV, Irimia D, Edlow AG, Alter G, Li JZ, Fasano AThe Journal of pediatricsReply. J Pediatr. 2021 01; 228:320-323.J Pediatr2020-09-18T00:00:002020Reply.32971143Yonker LM, Neilan AM, Bartsch Y, Patel AB, Regan J, Arya P, Gootkind E, Park G, Hardcastle M, St John A, Appleman L, Chiu ML, Fialkowski A, De La Flor D, Lima R, Bordt EA, Yockey LJ, D'Avino P, Fischinger S, Shui JE, Lerou PH, Bonventre JV, Yu XG, Ryan ET, Bassett IV, Irimia D, Edlow AG, Alter G, Li JZ, Fasano AThe Journal of pediatricsReply. J Pediatr. 2021 01; 228:317-319.J Pediatr2020-09-21T00:00:002020Reply.Authorship 195491Authorship 1308805333275097Dieterle PB, Min J, Irimia D, Amir AeLifeDynamics of diffusive cell signaling relays. Elife. 2020 12 04; 9.Elife2020-12-04T00:00:002020Dynamics of diffusive cell signaling relays.Authorship 1478642Authorship 1314283133354109Irimia DMicrobiology insightsNeutrophil Swarms Are More Than the Accumulation of Cells. Microbiol Insights. 2020; 13:1178636120978272.Microbiol Insights2020-12-10T00:00:002020Neutrophil Swarms Are More Than the Accumulation of Cells.Authorship 13168381033417688Barros N, Alexander N, Viens A, Timmer K, Atallah N, Knooihuizen SAI, Hopke A, Scherer A, Dagher Z, Irimia D, Mansour MKThe Journal of infectious diseasesCytokine Augmentation Reverses Transplant Recipient Neutrophil Dysfunction Against the Human Fungal Pathogen Candida albicans. J Infect Dis. 2021 09 01; 224(5):894-902.J Infect Dis2021-09-01T00:00:002021Cytokine Augmentation Reverses Transplant Recipient Neutrophil Dysfunction Against the Human Fungal Pathogen Candida albicans.Authorship 1320887633436661Babatunde KA, Wang X, Hopke A, Lannes N, Mantel PY, Irimia DScientific reportsChemotaxis and swarming in differentiated HL-60 neutrophil-like cells. Sci Rep. 2021 01 12; 11(1):778.Sci Rep2021-01-12T00:00:002021Chemotaxis and swarming in differentiated HL-60 neutrophil-like cells.Authorship 1326037733544453Jalali F, Ellett F, Balani P, Duncan MJ, Dewhirst FE, Borisy GG, Irimia DMicrobiologyOpenNo man's land: Species-specific formation of exclusion zones bordering Actinomyces graevenitzii microcolonies in nanoliter cultures. Microbiologyopen. 2021 01; 10(1):e1137.Microbiologyopen2021-02-05T00:00:002021No man's land: Species-specific formation of exclusion zones bordering Actinomyces graevenitzii microcolonies in nanoliter cultures.Authorship 133161611Authorship 13316241533589825Bartsch YC, Wang C, Zohar T, Fischinger S, Atyeo C, Burke JS, Kang J, Edlow AG, Fasano A, Baden LR, Nilles EJ, Woolley AE, Karlson EW, Hopke AR, Irimia D, Fischer ES, Ryan ET, Charles RC, Julg BD, Lauffenburger DA, Yonker LM, Alter GNature medicineHumoral signatures of protective and pathological SARS-CoV-2 infection in children. Nat Med. 2021 03; 27(3):454-462.Nat Med2021-02-12T00:00:002021Humoral signatures of protective and pathological SARS-CoV-2 infection in children.33589340Yonker LM, Marand A, Muldur S, Hopke A, Leung HM, De La Flor D, Park G, Pinsky H, Guthrie LB, Tearney GJ, Irimia D, Hurley BPJournal of cystic fibrosis : official journal of the European Cystic Fibrosis SocietyNeutrophil dysfunction in cystic fibrosis. J Cyst Fibros. 2021 11; 20(6):1062-1071.J Cyst Fibros2021-02-13T00:00:002021Neutrophil dysfunction in cystic fibrosis.Authorship 1336816933681682Knooihuizen SAI, Alexander NJ, Hopke A, Barros N, Viens A, Scherer A, Atallah NJ, Dagher Z, Irimia D, Chung RT, Mansour MKHepatology communicationsLoss of Coordinated Neutrophil Responses to the Human Fungal Pathogen, Candida albicans, in Patients With Cirrhosis. Hepatol Commun. 2021 03; 5(3):502-515.Hepatol Commun2021-01-05T00:00:002021Loss of Coordinated Neutrophil Responses to the Human Fungal Pathogen, Candida albicans, in Patients With Cirrhosis.Authorship 1338740933735890Muldur S, Ellett F, Marand AL, Marvil C, Branda JA, LeMieux JE, Raff AB, Strle K, Irimia DCells, tissues, organsMicrofluidic Assays for Probing Neutrophil-Borrelia Interactions in Blood During Lyme Disease. Cells Tissues Organs. 2022; 211(3):313-323.Cells Tissues Organs2021-03-18T00:00:002021Microfluidic Assays for Probing Neutrophil-Borrelia Interactions in Blood During Lyme Disease.Authorship 13647421234140358Kienle K, Glaser KM, Eickhoff S, Mihlan M, Knöpper K, Reátegui E, Epple MW, Gunzer M, Baumeister R, Tarrant TK, Germain RN, Irimia D, Kastenmüller W, Lämmermann TScience (New York, N.Y.)Neutrophils self-limit swarming to contain bacterial growth in vivo. Science. 2021 06 18; 372(6548).Science2021-06-18T00:00:002021Neutrophils self-limit swarming to contain bacterial growth in vivo.Authorship 1376921634286713Kim JJ, Jorfi M, Tanzi RE, Kim DY, Doyle PS, Irimia DLab on a chipPatterning of interconnected human brain spheroids. Lab Chip. 2021 09 14; 21(18):3532-3540.Lab Chip2021-09-14T00:00:002021Patterning of interconnected human brain spheroids.Authorship 1379104434324592Scherer AK, Hopke A, Sykes DB, Irimia D, Mansour MKPLoS pathogensHost defense against fungal pathogens: Adaptable neutrophil responses and the promise of therapeutic opportunities? PLoS Pathog. 2021 07; 17(7):e1009691.PLoS Pathog2021-07-29T00:00:002021Host defense against fungal pathogens: Adaptable neutrophil responses and the promise of therapeutic opportunities?Authorship 166773Authorship 14000661934587206Hopke A, Mela A, Ellett F, Carter-House D, Peña JF, Stajich JE, Altamirano S, Lovett B, Egan M, Kale S, Kronholm I, Guerette P, Szewczyk E, McCluskey K, Breslauer D, Shah H, Coad BR, Momany M, Irimia DPloS oneCrowdsourced analysis of fungal growth and branching on microfluidic platforms. PLoS One. 2021; 16(9):e0257823.PLoS One2021-09-29T00:00:002021Crowdsourced analysis of fungal growth and branching on microfluidic platforms.true1Lecturer on Surgery, Part-timeLecturer on Surgery, Part-timeAuthorship 14101795Authorship 1410910534785640Hadjitheodorou A, Bell GRR, Ellett F, Shastry S, Irimia D, Collins SR, Theriot JANature communicationsDirectional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity. Nat Commun. 2021 11 16; 12(1):6619.Nat Commun2021-11-16T00:00:002021Directional reorientation of migrating neutrophils is limited by suppression of receptor input signaling at the cell rear through myosin II activity.34814186Chiang N, Sakuma M, Rodriguez AR, Spur BW, Irimia D, Serhan CNBloodResolvin T-series reduce neutrophil extracellular traps. Blood. 2022 02 24; 139(8):1222-1233.Blood2022-02-24T00:00:002022Resolvin T-series reduce neutrophil extracellular traps.Authorship 1420857734899737Muldur S, Vadysirisack DD, Ragunathan S, Tang Y, Ricardo A, Sayegh CE, Irimia DFrontiers in immunologyHuman Neutrophils Respond to Complement Activation and Inhibition in Microfluidic Devices. Front Immunol. 2021; 12:777932.Front Immunol2021-11-24T00:00:002021Human Neutrophils Respond to Complement Activation and Inhibition in Microfluidic Devices.Authorship 14217101534981052Boribong BP, LaSalle TJ, Bartsch YC, Ellett F, Loiselle ME, Davis JP, Gonye ALK, Hajizadeh S, Kreuzer J, Pillai S, Haas W, Edlow A, Fasano A, Alter G, Irimia D, Sade-Feldman M, Yonker LMbioRxiv : the preprint server for biologyNeutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children. bioRxiv. 2021 Dec 20.bioRxiv2021-12-20T00:00:002021Neutrophil Profiles of Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children.Authorship 1427928835084421Sakuma M, Wang X, Ellett F, Edd JF, Babatunde KA, Viens A, Mansour MK, Irimia DLab on a chipMicrofluidic capture of chromatin fibres measures neutrophil extracellular traps (NETs) released in a drop of human blood. Lab Chip. 2022 03 01; 22(5):936-944.Lab Chip2022-03-01T00:00:002022Microfluidic capture of chromatin fibres measures neutrophil extracellular traps (NETs) released in a drop of human blood.Authorship 2134714Authorship 14303603Authorship 14318851035112383Habibabady ZA, Sendil S, Ellett F, Pollok F, Elias GF, French BM, Sun W, Braileanu G, Burdorf L, Irimia D, Pierson RN, Azimzadeh AMXenotransplantationHuman erythrocyte fragmentation during ex-vivo pig organ perfusion. Xenotransplantation. 2022 03; 29(2):e12729.Xenotransplantation2022-02-02T00:00:002022Human erythrocyte fragmentation during ex-vivo pig organ perfusion.35100458Ellett F, Marand AL, Irimia DJournal of leukocyte biologyMultifactorial assessment of neutrophil chemotaxis efficiency from a drop of blood. J Leukoc Biol. 2022 06; 111(6):1175-1184.J Leukoc Biol2022-01-31T00:00:002022Multifactorial assessment of neutrophil chemotaxis efficiency from a drop of blood.true1Associate Professor of SurgeryAssociate Professor of SurgeryAuthorship 143536716Authorship 14369091035277418Viens AL, Timmer KD, Alexander NJ, Barghout R, Milosevic J, Hopke A, Atallah NJ, Scherer AK, Sykes DB, Irimia D, Mansour MKJournal of immunology (Baltimore, Md. : 1950)TLR Signaling Rescues Fungicidal Activity in Syk-Deficient Neutrophils. J Immunol. 2022 04 01; 208(7):1664-1674.J Immunol2022-03-11T00:00:002022TLR Signaling Rescues Fungicidal Activity in Syk-Deficient Neutrophils.35355310Sykes DB, Martinelli MM, Negoro P, Xu S, Maxcy K, Timmer K, Viens AL, Alexander NJ, Atallah J, Snarr BD, Baistrocchi SR, Atallah NJ, Hopke A, Scherer A, Rosales I, Irimia D, Sheppard DC, Mansour MKJournal of leukocyte biologyTransfusable neutrophil progenitors as cellular therapy for the prevention of invasive fungal infections. J Leukoc Biol. 2022 06; 111(6):1133-1145.J Leukoc Biol2022-03-31T00:00:002022Transfusable neutrophil progenitors as cellular therapy for the prevention of invasive fungal infections.true1Associate Professor of MedicineAssociate Professor of MedicineAuthorship 3626743true1Assistant Professor of NeurologyAssistant Professor of NeurologyAuthorship 3871235Authorship 146864011Authorship 145845218Authorship 14627011835799137Yonker LM, Badaki-Makun O, Arya P, Boribong BP, Moraru G, Fenner B, Rincon J, Hopke A, Rogers B, Hinson J, Fasano A, Lee L, Kehoe SM, Larson SD, Chavez H, Levin S, Moldawer LL, Irimia DBMC infectious diseasesCorrection to: Monocyte anisocytosis increases during multisystem inflammatory syndrome in children with cardiovascular complications. BMC Infect Dis. 2022 Jul 07; 22(1):595.BMC Infect Dis2022-07-07T00:00:002022Correction to: Monocyte anisocytosis increases during multisystem inflammatory syndrome in children with cardiovascular complications.35787254Rosu CA, Martens AM, Sumner J, Farkas EJ, Arya P, Arauz AB, Madhavan VL, Chavez H, Larson SD, Badaki-Makun O, Irimia D, Yonker LMBMC pediatricsHeterogeneity in the evaluation of suspected MIS-C: a cross-sectional vignette-based survey. BMC Pediatr. 2022 07 04; 22(1):392.BMC Pediatr2022-07-04T00:00:002022Heterogeneity in the evaluation of suspected MIS-C: a cross-sectional vignette-based survey.35725405Yonker LM, Badaki-Makun O, Arya P, Boribong BP, Moraru G, Fenner B, Rincon J, Hopke A, Rogers B, Hinson J, Fasano A, Lee L, Kehoe SM, Larson SD, Chavez H, Levin S, Moldawer LL, Irimia DBMC infectious diseasesMonocyte anisocytosis increases during multisystem inflammatory syndrome in children with cardiovascular complications. BMC Infect Dis. 2022 Jun 20; 22(1):563.BMC Infect Dis2022-06-20T00:00:002022Monocyte anisocytosis increases during multisystem inflammatory syndrome in children with cardiovascular complications.Authorship 1608831true1Assistant Professor of NeurologyAssistant Professor of NeurologyAuthorship 14925869Authorship 1503271436267914Hopke A, Lin T, Scherer AK, Shay AE, Timmer KD, Wilson-Mifsud B, Mansour MK, Serhan CN, Irimia D, Hurley BPiScienceTranscellular biosynthesis of leukotriene B4 orchestrates neutrophil swarming to fungi. iScience. 2022 Oct 21; 25(10):105226.iScience2022-09-28T00:00:002022Transcellular biosynthesis of leukotriene B4 orchestrates neutrophil swarming to fungi.36341418Prichard A, Khuu L, Whitmore LC, Irimia D, Allen LHFrontiers in immunologyHelicobacter pylori-infected human neutrophils exhibit impaired chemotaxis and a uropod retraction defect. Front Immunol. 2022; 13:1038349.Front Immunol2022-10-20T00:00:002022Helicobacter pylori-infected human neutrophils exhibit impaired chemotaxis and a uropod retraction defect.Authorship 15094771636476388Boribong BP, LaSalle TJ, Bartsch YC, Ellett F, Loiselle ME, Davis JP, Gonye ALK, Sykes DB, Hajizadeh S, Kreuzer J, Pillai S, Haas W, Edlow AG, Fasano A, Alter G, Irimia D, Sade-Feldman M, Yonker LMCell reports. MedicineNeutrophil profiles of pediatric COVID-19 and multisystem inflammatory syndrome in children. Cell Rep Med. 2022 12 20; 3(12):100848.Cell Rep Med2022-11-21T00:00:002022Neutrophil profiles of pediatric COVID-19 and multisystem inflammatory syndrome in children.Authorship 15234277Authorship 1524902436827986Hadjitheodorou A, Bell GRR, Ellett F, Irimia D, Tibshirani R, Collins SR, Theriot JACell systemsLeading edge competition promotes context-dependent responses to receptor inputs to resolve directional dilemmas in neutrophil migration. Cell Syst. 2023 03 15; 14(3):196-209.e6.Cell Syst2023-02-23T00:00:002023Leading edge competition promotes context-dependent responses to receptor inputs to resolve directional dilemmas in neutrophil migration.36752208Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN, Perretti MJCI insightProresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. JCI Insight. 2023 02 08; 8(3).JCI Insight2023-02-08T00:00:002023Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis.Authorship 1529140236857665Ellett F, Irimia DLab on a chipPassive redirection filters minimize red blood cell contamination during neutrophil chemotaxis assays using whole blood. Lab Chip. 2023 03 28; 23(7):1879-1885.Lab Chip2023-03-28T00:00:002023Passive redirection filters minimize red blood cell contamination during neutrophil chemotaxis assays using whole blood.Authorship 15338221336936945Frydman GH, Ellett F, Jorgensen J, Marand AL, Zukerberg L, Selig MK, Tessier SN, Wong KHK, Olaleye D, Vanderburg CR, Fox JG, Tompkins RG, Irimia DFrontiers in immunologyMegakaryocytes respond during sepsis and display innate immune cell behaviors. Front Immunol. 2023; 14:1083339.Front Immunol2023-03-02T00:00:002023Megakaryocytes respond during sepsis and display innate immune cell behaviors.Authorship 15682059Authorship 156833910Authorship 15698522Authorship 1570034837283724Ellett F, Kacamak NI, Alvarez CR, Oliveira EHS, Hasturk H, Paster BJ, Kantarci A, Irimia DJournal of oral microbiologyFusobacterium nucleatum dissemination by neutrophils. J Oral Microbiol. 2023; 15(1):2217067.J Oral Microbiol2023-06-04T00:00:002023Fusobacterium nucleatum dissemination by neutrophils.37425266Kane AS, Boribong BP, Loiselle M, Chitnis AP, Chavez H, Moldawer LL, Larson SD, Badaki-Makun O, Irimia D, Yonker LMFrontiers in pediatricsMonocyte anisocytosis corresponds with increasing severity of COVID-19 in children. Front Pediatr. 2023; 11:1177048.Front Pediatr2023-06-23T00:00:002023Monocyte anisocytosis corresponds with increasing severity of COVID-19 in children.37425711Strickland E, Pan D, Godfrey C, Kim JS, Hopke A, Degrange M, Villavicencio B, Mansour MK, Zerbe CS, Irimia D, Amir A, Weiner ODbioRxiv : the preprint server for biologySelf-extinguishing relay waves enable homeostatic control of human neutrophil swarming. bioRxiv. 2023 Jun 28.bioRxiv2023-06-28T00:00:002023Self-extinguishing relay waves enable homeostatic control of human neutrophil swarming.37205536Gural N, Irimia DResearch squareMicrofluidic Devices for Precise Measurements of Cell Directionality Reveal a Role for Glutamine during Cell Migration. Res Sq. 2023 May 03.Res Sq2023-05-03T00:00:002023Microfluidic Devices for Precise Measurements of Cell Directionality Reveal a Role for Glutamine during Cell Migration.Authorship 15855241137620442Jorfi M, Park J, Hall CK, Lin CJ, Chen M, von Maydell D, Kruskop JM, Kang B, Choi Y, Prokopenko D, Irimia D, Kim DY, Tanzi RENature neuroscienceInfiltrating CD8+ T cells exacerbate Alzheimer's disease pathology in a 3D human neuroimmune axis model. Nat Neurosci. 2023 09; 26(9):1489-1504.Nat Neurosci2023-08-24T00:00:002023Infiltrating CD8+ T cells exacerbate Alzheimer's disease pathology in a 3D human neuroimmune axis model.true1Helen Andrus Benedict Professor of SurgeryHelen Andrus Benedict Professor of SurgeryAuthorship 1601020737886517Edgerton M, Rojas I, Kumar R, Li R, Salvatori O, Abrams S, Irimia DResearch squareNeutrophil swarms containing myeloid-derived suppressor cells are crucial for limiting oral mucosal infection by C. albicans. Res Sq. 2023 Oct 09.Res Sq2023-10-09T00:00:002023Neutrophil swarms containing myeloid-derived suppressor cells are crucial for limiting oral mucosal infection by C. albicans.Authorship 1616662238155198Gural N, Irimia DScientific reportsMicrofluidic devices for precise measurements of cell directionality reveal a role for glutamine during cell migration. Sci Rep. 2023 12 27; 13(1):23032.Sci Rep2023-12-27T00:00:002023Microfluidic devices for precise measurements of cell directionality reveal a role for glutamine during cell migration.true1Visiting Professor of MedicineVisiting Professor of Medicinetrue1Judah Folkman Professor of Vascular Biology in the Department of SurgeryJudah Folkman Professor of Vascular Biology in the Department of SurgeryAuthorship 892912Authorship 6822923Authorship 682293224155501Aksan A, Irimia D, He X, Toner MJournal of applied physicsDesiccation kinetics of biopreservation solutions in microchannels. J Appl Phys. 2006; 99(6):2181280.J Appl Phys2006-01-01T00:00:002006Desiccation kinetics of biopreservation solutions in microchannels.24073020Koria P, Bhushan A, Irimia D, Yarmush MLNano LIFEMICROFLUIDIC DEVICE FOR EXAMINING DIRECTIONAL SENSING IN DENDRITIC CELL CHEMOTAXIS. Nano Life. 2012 Jun 01; 2(2).Nano Life2012-06-01T00:00:002012MICROFLUIDIC DEVICE FOR EXAMINING DIRECTIONAL SENSING IN DENDRITIC CELL CHEMOTAXIS.Authorship 697849524324148Prentice-Mott HV, Chang CH, Mahadevan L, Mitchison TJ, Irimia D, Shah JVProceedings of the National Academy of Sciences of the United States of AmericaBiased migration of confined neutrophil-like cells in asymmetric hydraulic environments. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):21006-11.Proc Natl Acad Sci U S A2013-12-09T00:00:002013Biased migration of confined neutrophil-like cells in asymmetric hydraulic environments.Authorship 703218624419464Hamza B, Wong E, Patel S, Cho H, Martel J, Irimia DIntegrative biology : quantitative biosciences from nano to macroRetrotaxis of human neutrophils during mechanical confinement inside microfluidic channels. Integr Biol (Camb). 2014 Feb; 6(2):175-83.Integr Biol (Camb)2014-02-01T00:00:002014Retrotaxis of human neutrophils during mechanical confinement inside microfluidic channels.Authorship 70562413Authorship 705625424485508Baik SH, Cha MY, Hyun YM, Cho H, Hamza B, Kim DK, Han SH, Choi H, Kim KH, Moon M, Lee J, Kim M, Irimia D, Mook-Jung INeurobiology of agingMigration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model. Neurobiol Aging. 2014 Jun; 35(6):1286-92.Neurobiol Aging2014-01-08T00:00:002014Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model.24430002Cho H, Hamza B, Wong EA, Irimia DLab on a chipOn-demand, competing gradient arrays for neutrophil chemotaxis. Lab Chip. 2014 Mar 07; 14(5):972-978.Lab Chip2014-03-07T00:00:002014On-demand, competing gradient arrays for neutrophil chemotaxis.Authorship 705778124560508Irimia DMethods in cell biologyCell migration in confined environments. Methods Cell Biol. 2014; 121:141-53.Methods Cell Biol2014-01-01T00:00:002014Cell migration in confined environments.Authorship 31620611Authorship 7070681724574340Robertson AL, Holmes GR, Bojarczuk AN, Burgon J, Loynes CA, Chimen M, Sawtell AK, Hamza B, Willson J, Walmsley SR, Anderson SR, Coles MC, Farrow SN, Solari R, Jones S, Prince LR, Irimia D, Rainger GE, Kadirkamanathan V, Whyte MK, Renshaw SAScience translational medicineA zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism. Sci Transl Med. 2014 Feb 26; 6(225):225ra29.Sci Transl Med2014-02-26T00:00:002014A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism.Authorship 2157459Authorship 26051616Authorship 1937041Authorship 7371318Authorship 737132724880044Nery FC, Atai NA, da Hora CC, Kim EY, Hettich J, Mempel TR, Breakefield XO, Irimia DJournal of neuroscience methodsMicrofluidic platform to evaluate migration of cells from patients with DYT1 dystonia. J Neurosci Methods. 2014 Jul 30; 232:181-188.J Neurosci Methods2014-05-29T00:00:002014Microfluidic platform to evaluate migration of cells from patients with DYT1 dystonia.Authorship 737360624962731Jones CN, Hoang AN, Dimisko L, Hamza B, Martel J, Irimia DJournal of visualized experiments : JoVEMicrofluidic platform for measuring neutrophil chemotaxis from unprocessed whole blood. J Vis Exp. 2014 Jun 03; (88).J Vis Exp2014-06-03T00:00:002014Microfluidic platform for measuring neutrophil chemotaxis from unprocessed whole blood.Authorship 2976553Authorship 3179754GF47GalitFrydmanGalit H. Frydman, Ph.D.130448Frydman, GalitLecturer on Surgery, Part-timeAuthorship 745505725129619Wong IY, Javaid S, Wong EA, Perk S, Haber DA, Toner M, Irimia DNature materialsCollective and individual migration following the epithelial-mesenchymal transition. Nat Mater. 2014 Nov; 13(11):1063-71.Nat Mater2014-08-17T00:00:002014Collective and individual migration following the epithelial-mesenchymal transition.Authorship 754088524809064Hoang AN, Jones CN, Dimisko L, Hamza B, Martel J, Kojic N, Irimia DTechnologyMeasuring neutrophil speed and directionality during chemotaxis, directly from a droplet of whole blood. Technology (Singap World Sci). 2013 Oct 02; 1(1):49.Technology (Singap World Sci)2013-10-02T00:00:002013Measuring neutrophil speed and directionality during chemotaxis, directly from a droplet of whole blood.25183261Boneschansker L, Yan J, Wong E, Briscoe DM, Irimia DNature communicationsMicrofluidic platform for the quantitative analysis of leukocyte migration signatures. Nat Commun. 2014 Sep 03; 5:4787.Nat Commun2014-09-03T00:00:002014Microfluidic platform for the quantitative analysis of leukocyte migration signatures.Authorship 3934016Authorship 7717847Authorship 7717852Authorship 7717865Authorship 7717873Authorship 771788725436220Yan J, Irimia DTechnologyStochastic variations of migration speed between cells in clonal populations. Technology (Singap World Sci). 2014 Sep; 2(3):185-188.Technology (Singap World Sci)2014-09-01T00:00:002014Stochastic variations of migration speed between cells in clonal populations.25291524Nery FC, da Hora CC, Yaqub U, Zhang X, McCarthy DM, Bhide PG, Irimia D, Breakefield XOJournal of neuroscience methodsNew methods for investigation of neuronal migration in embryonic brain explants. J Neurosci Methods. 2015 Jan 15; 239:80-4.J Neurosci Methods2014-10-05T00:00:002014New methods for investigation of neuronal migration in embryonic brain explants.25468905Hori Y, Takeda S, Cho H, Wegmann S, Shoup TM, Takahashi K, Irimia D, Elmaleh DR, Hyman BT, Hudry EThe Journal of biological chemistryA Food and Drug Administration-approved asthma therapeutic agent impacts amyloid ß in the brain in a transgenic model of Alzheimer disease. J Biol Chem. 2015 Jan 23; 290(4):1966-78.J Biol Chem2014-12-02T00:00:002014A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid ß in the brain in a transgenic model of Alzheimer disease.25419536Sung Y, Lue N, Hamza B, Martel J, Irimia D, Dasari RR, Choi W, Yaqoob Z, So PPhysical review appliedThree-Dimensional Holographic Refractive-Index Measurement of Continuously Flowing Cells in a Microfluidic Channel. Phys Rev Appl. 2014 Feb 27; 1.Phys Rev Appl2014-02-27T00:00:002014Three-Dimensional Holographic Refractive-Index Measurement of Continuously Flowing Cells in a Microfluidic Channel.25412288Aranyosi AJ, Wong EA, Irimia DLab on a chipA neutrophil treadmill to decouple spatial and temporal signals during chemotaxis. Lab Chip. 2015 Jan 21; 15(2):549-556.Lab Chip2015-01-21T00:00:002015A neutrophil treadmill to decouple spatial and temporal signals during chemotaxis.Authorship 7719941025489947Jones CN, Moore M, Dimisko L, Alexander A, Ibrahim A, Hassell BA, Warren HS, Tompkins RG, Fagan SP, Irimia DPloS oneSpontaneous neutrophil migration patterns during sepsis after major burns. PLoS One. 2014; 9(12):e114509.PLoS One2014-12-09T00:00:002014Spontaneous neutrophil migration patterns during sepsis after major burns.Authorship 477921Authorship 568688Authorship 652753Authorship 2556667Authorship 2745933Authorship 5690516Authorship 5742315Authorship 3941985Authorship 51378913Authorship 4704241Authorship 5069783FEE1FelixEllettFelix Eiran John Ellett, Ph.D.136820Ellett, FelixInstructor in SurgeryAuthorship 578856Authorship 626466Authorship 655478Authorship 4650434Authorship 3222528Authorship 605776Authorship 311096Authorship 2887451125903640Bruneau S, Wedel J, Fakhouri F, Nakayama H, Boneschansker L, Irimia D, Daly KP, Briscoe DMPediatric nephrology (Berlin, Germany)Translational implications of endothelial cell dysfunction in association with chronic allograft rejection. Pediatr Nephrol. 2016 Jan; 31(1):41-51.Pediatr Nephrol2015-04-24T00:00:002015Translational implications of endothelial cell dysfunction in association with chronic allograft rejection.Authorship 4265095Authorship 2160792Authorship 7837292Authorship 7837305Authorship 783731625914896Heo YS, Nagrath S, Moore AL, Zeinali M, Irimia D, Stott SL, Toth TL, Toner MTechnology"Universal" vitrification of cells by ultra-fast cooling. Technology (Singap World Sci). 2015 Mar; 3(1):64-71.Technology (Singap World Sci)2015-03-01T00:00:002015"Universal" vitrification of cells by ultra-fast cooling.25987163Hamza B, Irimia DLab on a chipWhole blood human neutrophil trafficking in a microfluidic model of infection and inflammation. Lab Chip. 2015 Jun 21; 15(12):2625-33.Lab Chip2015-06-21T00:00:002015Whole blood human neutrophil trafficking in a microfluidic model of infection and inflammation.Authorship 3036744Authorship 3693913Authorship 3354861Authorship 3883403Authorship 3966585Authorship 5003011Authorship 5484161Authorship 4494751Authorship 4731973Authorship 816444326161433Hsu CH, Chen C, Irimia D, Toner MTechnologyFast sorting of CD4+ T cells from whole blood using glass microbubbles. Technology (Singap World Sci). 2015 Mar; 3(1):38-44.Technology (Singap World Sci)2015-03-01T00:00:002015Fast sorting of CD4+ T cells from whole blood using glass microbubbles.Authorship 824745826272935Jones CN, Dimisko L, Forrest K, Judice K, Poznansky MC, Markmann JF, Vyas JM, Irimia DThe Journal of infectious diseasesHuman Neutrophils Are Primed by Chemoattractant Gradients for Blocking the Growth of Aspergillus fumigatus. J Infect Dis. 2016 Feb 01; 213(3):465-75.J Infect Dis2015-08-12T00:00:002015Human Neutrophils Are Primed by Chemoattractant Gradients for Blocking the Growth of Aspergillus fumigatus.Authorship 8404171426458742Takeda S, Wegmann S, Cho H, DeVos SL, Commins C, Roe AD, Nicholls SB, Carlson GA, Pitstick R, Nobuhara CK, Costantino I, Frosch MP, Müller DJ, Irimia D, Hyman BTNature communicationsNeuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain. Nat Commun. 2015 Oct 13; 6:8490.Nat Commun2015-10-13T00:00:002015Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.Authorship 8409626Authorship 840963726488221Orr SK, Butler KL, Hayden D, Tompkins RG, Serhan CN, Irimia DCritical care medicineGene Expression of Proresolving Lipid Mediator Pathways Is Associated With Clinical Outcomes in Trauma Patients. Crit Care Med. 2015 Dec; 43(12):2642-50.Crit Care Med2015-12-01T00:00:002015Gene Expression of Proresolving Lipid Mediator Pathways Is Associated With Clinical Outcomes in Trauma Patients.26325525Jain NG, Wong EA, Aranyosi AJ, Boneschansker L, Markmann JF, Briscoe DM, Irimia DIntegrative biology : quantitative biosciences from nano to macroMicrofluidic mazes to characterize T-cell exploration patterns following activation in vitro. Integr Biol (Camb). 2015 Nov; 7(11):1423-31.Integr Biol (Camb)2015-11-01T00:00:002015Microfluidic mazes to characterize T-cell exploration patterns following activation in vitro.Authorship 84185312Authorship 841854926509319Inoue Y, Yu YM, Kurihara T, Vasilyev A, Ibrahim A, Oklu R, Zhao G, Nair AV, Brown D, Fischman AJ, Tompkins RG, Irimia DCritical care medicineKidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2. Crit Care Med. 2016 May; 44(5):e241-52.Crit Care Med2016-05-01T00:00:002016Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2.26503597Cho H, Seo JH, Wong KH, Terasaki Y, Park J, Bong K, Arai K, Lo EH, Irimia DScientific reportsThree-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology. Sci Rep. 2015 Oct 27; 5:15222.Sci Rep2015-10-27T00:00:002015Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology.Authorship 846183626545155Bong KW, Kim JJ, Cho H, Lim E, Doyle PS, Irimia DLangmuir : the ACS journal of surfaces and colloidsSynthesis of Cell-Adhesive Anisotropic Multifunctional Particles by Stop Flow Lithography and Streptavidin-Biotin Interactions. Langmuir. 2015 Dec 08; 31(48):13165-71.Langmuir2015-11-25T00:00:002015Synthesis of Cell-Adhesive Anisotropic Multifunctional Particles by Stop Flow Lithography and Streptavidin-Biotin Interactions.Authorship 5075365Authorship 856829626764383Prentice-Mott HV, Meroz Y, Carlson A, Levine MA, Davidson MW, Irimia D, Charras GT, Mahadevan L, Shah JVProceedings of the National Academy of Sciences of the United States of AmericaDirectional memory arises from long-lived cytoskeletal asymmetries in polarized chemotactic cells. Proc Natl Acad Sci U S A. 2016 Feb 02; 113(5):1267-72.Proc Natl Acad Sci U S A2016-01-13T00:00:002016Directional memory arises from long-lived cytoskeletal asymmetries in polarized chemotactic cells.Authorship 85711413Authorship 857115426819316Jones CN, Hoang AN, Martel JM, Dimisko L, Mikkola A, Inoue Y, Kuriyama N, Yamada M, Hamza B, Kaneki M, Warren HS, Brown DE, Irimia DJournal of leukocyte biologyMicrofluidic assay for precise measurements of mouse, rat, and human neutrophil chemotaxis in whole-blood droplets. J Leukoc Biol. 2016 07; 100(1):241-7.J Leukoc Biol2016-01-27T00:00:002016Microfluidic assay for precise measurements of mouse, rat, and human neutrophil chemotaxis in whole-blood droplets.26797289Boneschansker L, Inoue Y, Oklu R, Irimia DIntegrative biology : quantitative biosciences from nano to macroCapillary plexuses are vulnerable to neutrophil extracellular traps. Integr Biol (Camb). 2016 Feb; 8(2):149-55.Integr Biol (Camb)2016-01-22T00:00:002016Capillary plexuses are vulnerable to neutrophil extracellular traps.Authorship 867350926876805Wong KH, Sandlin RD, Carey TR, Miller KL, Shank AT, Oklu R, Maheswaran S, Haber DA, Irimia D, Stott SL, Toner MScientific reportsThe Role of Physical Stabilization in Whole Blood Preservation. Sci Rep. 2016 Feb 15; 6:21023.Sci Rep2016-02-15T00:00:002016The Role of Physical Stabilization in Whole Blood Preservation.Authorship 4164404Authorship 8807411Authorship 880742727194799Irimia D, Ellett FJournal of leukocyte biologyBig insights from small volumes: deciphering complex leukocyte behaviors using microfluidics. J Leukoc Biol. 2016 08; 100(2):291-304.J Leukoc Biol2016-05-18T00:00:002016Big insights from small volumes: deciphering complex leukocyte behaviors using microfluidics.27158677Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN, Perretti MJCI insightProresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. JCI Insight. 2016 Apr 21; 1(5):e85922.JCI Insight2016-04-21T00:00:002016Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis.Authorship 5545423Authorship 601252Authorship 8878701227332963Skoge M, Wong E, Hamza B, Bae A, Martel J, Kataria R, Keizer-Gunnink I, Kortholt A, Van Haastert PJ, Charras G, Janetopoulos C, Irimia DPloS oneA Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells. PLoS One. 2016; 11(6):e0154491.PLoS One2016-06-22T00:00:002016A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells.2Assistant Professor1Associate Professor0Full Professor4Instructor3LecturerAuthorship 626781027430720Boneschansker L, Nakayama H, Eisenga M, Wedel J, Klagsbrun M, Irimia D, Briscoe DMJournal of immunology (Baltimore, Md. : 1950)Netrin-1 Augments Chemokinesis in CD4+ T Cells In Vitro and Elicits a Proinflammatory Response In Vivo. J Immunol. 2016 08 15; 197(4):1389-98.J Immunol2016-07-18T00:00:002016Netrin-1 Augments Chemokinesis in CD4+ T Cells In Vitro and Elicits a Proinflammatory Response In Vivo.Authorship 8970776Authorship 9157017Authorship 915702427595351Kim JJ, Bong KW, Reátegui E, Irimia D, Doyle PSNature materialsPorous microwells for geometry-selective, large-scale microparticle arrays. Nat Mater. 2017 01; 16(1):139-146.Nat Mater2016-09-05T00:00:002016Porous microwells for geometry-selective, large-scale microparticle arrays.27630219Frydman GH, Le A, Ellett F, Jorgensen J, Fox JG, Tompkins RG, Irimia DJournal of leukocyte biologyTechnical Advance: Changes in neutrophil migration patterns upon contact with platelets in a microfluidic assay. J Leukoc Biol. 2017 03; 101(3):797-806.J Leukoc Biol2016-09-14T00:00:002016Technical Advance: Changes in neutrophil migration patterns upon contact with platelets in a microfluidic assay.Authorship 6201011Authorship 52308311Authorship 5664263Authorship 623470Authorship 2569936Authorship 3847576Authorship 948392528076396Ellett F, Jorgensen J, Frydman GH, Jones CN, Irimia DPLoS pathogensNeutrophil Interactions Stimulate Evasive Hyphal Branching by Aspergillus fumigatus. PLoS Pathog. 2017 01; 13(1):e1006154.PLoS Pathog2017-01-11T00:00:002017Neutrophil Interactions Stimulate Evasive Hyphal Branching by Aspergillus fumigatus.Authorship 51611Authorship 954426228151697Ellett F, Irimia DZebrafishMicrostructured Surface Arrays for Injection of Zebrafish Larvae. Zebrafish. 2017 04; 14(2):140-145.Zebrafish2017-02-02T00:00:002017Microstructured Surface Arrays for Injection of Zebrafish Larvae.Renal/Engineering in MedicineAuthorship 965824428186323Dang I, Linkner J, Yan J, Irimia D, Faix J, Gautreau ABiology of the cellThe Arp2/3 inhibitory protein Arpin is dispensable for chemotaxis. Biol Cell. 2017 Apr; 109(4):162-166.Biol Cell2017-03-07T00:00:002017The Arp2/3 inhibitory protein Arpin is dispensable for chemotaxis.16365152Tharp WG, Yadav R, Irimia D, Upadhyaya A, Samadani A, Hurtado O, Liu SY, Munisamy S, Brainard DM, Mahon MJ, Nourshargh S, van Oudenaarden A, Toner MG, Poznansky MCJournal of leukocyte biologyNeutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo. J Leukoc Biol. 2006 Mar; 79(3):539-54.J Leukoc Biol2005-12-19T00:00:002005Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo.18094764Vu HN, Li Y, Casali M, Irimia D, Megeed Z, Yarmush MLLab on a chipA microfluidic bioreactor for increased active retrovirus output. Lab Chip. 2008 Jan; 8(1):75-80.Lab Chip2007-10-30T00:00:002007A microfluidic bioreactor for increased active retrovirus output.19023476Hsu CH, Di Carlo D, Chen C, Irimia D, Toner MLab on a chipMicrovortex for focusing, guiding and sorting of particles. Lab Chip. 2008 Dec; 8(12):2128-34.Lab Chip2008-10-30T00:00:002008Microvortex for focusing, guiding and sorting of particles.19686388Stoothoff W, Jones PB, Spires-Jones TL, Joyner D, Chhabra E, Bercury K, Fan Z, Xie H, Bacskai B, Edd J, Irimia D, Hyman BTJournal of neurochemistryDifferential effect of three-repeat and four-repeat tau on mitochondrial axonal transport. J Neurochem. 2009 Oct; 111(2):417-27.J Neurochem2009-08-03T00:00:002009Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport.15475590Irimia D, Karlsson JOBiophysical journalKinetics of intracellular ice formation in one-dimensional arrays of interacting biological cells. Biophys J. 2005 Jan; 88(1):647-60.Biophys J2004-10-08T00:00:002004Kinetics of intracellular ice formation in one-dimensional arrays of interacting biological cells.15059017Stott SL, Irimia D, Karlsson JOTechnology in cancer research & treatmentParametric analysis of intercellular ice propagation during cryosurgery, simulated using monte carlo techniques. Technol Cancer Res Treat. 2004 Apr; 3(2):113-23.Technol Cancer Res Treat2004-04-01T00:00:002004Parametric analysis of intercellular ice propagation during cryosurgery, simulated using monte carlo techniques.20676444Ambravaneswaran V, Wong IY, Aranyosi AJ, Toner M, Irimia DIntegrative biology : quantitative biosciences from nano to macroDirectional decisions during neutrophil chemotaxis inside bifurcating channels. Integr Biol (Camb). 2010 Nov; 2(11-12):639-47.Integr Biol (Camb)2010-08-02T00:00:002010Directional decisions during neutrophil chemotaxis inside bifurcating channels.20689600Butler KL, Ambravaneswaran V, Agrawal N, Bilodeau M, Toner M, Tompkins RG, Fagan S, Irimia DPloS oneBurn injury reduces neutrophil directional migration speed in microfluidic devices. PLoS One. 2010 Jul 30; 5(7):e11921.PLoS One2010-07-30T00:00:002010Burn injury reduces neutrophil directional migration speed in microfluidic devices.114 16th StreetMassachusetts General HospitalSurgery/BioMEMS Resource Center, Rm #1404114 16th StreetCharlestown02129MA18419138Kelly RT, Tang K, Irimia D, Toner M, Smith RDAnalytical chemistryElastomeric microchip electrospray emitter for stable cone-jet mode operation in the nanoflow regime. Anal Chem. 2008 May 15; 80(10):3824-31.Anal Chem2008-04-18T00:00:002008Elastomeric microchip electrospray emitter for stable cone-jet mode operation in the nanoflow regime.18596266Maheswaran S, Sequist LV, Nagrath S, Ulkus L, Brannigan B, Collura CV, Inserra E, Diederichs S, Iafrate AJ, Bell DW, Digumarthy S, Muzikansky A, Irimia D, Settleman J, Tompkins RG, Lynch TJ, Toner M, Haber DAThe New England journal of medicineDetection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med. 2008 Jul 24; 359(4):366-77.N Engl J Med2008-07-02T00:00:002008Detection of mutations in EGFR in circulating lung-cancer cells.17414933Cheng X, Irimia D, Dixon M, Ziperstein JC, Demirci U, Zamir L, Tompkins RG, Toner M, Rodriguez WRJournal of acquired immune deficiency syndromes (1999)A microchip approach for practical label-free CD4+ T-cell counting of HIV-infected subjects in resource-poor settings. J Acquir Immune Defic Syndr. 2007 Jul 01; 45(3):257-61.J Acquir Immune Defic Syndr2007-07-01T00:00:002007A microchip approach for practical label-free CD4+ T-cell counting of HIV-infected subjects in resource-poor settings.19450463Irimia D, Balázsi G, Agrawal N, Toner MBiophysical journalAdaptive-control model for neutrophil orientation in the direction of chemical gradients. Biophys J. 2009 May 20; 96(10):3897-916.Biophys J2009-05-20T00:00:002009Adaptive-control model for neutrophil orientation in the direction of chemical gradients.22450811Oh SF, Dona M, Fredman G, Krishnamoorthy S, Irimia D, Serhan CNJournal of immunology (Baltimore, Md. : 1950)Resolvin E2 formation and impact in inflammation resolution. J Immunol. 2012 May 01; 188(9):4527-34.J Immunol2012-03-26T00:00:002012Resolvin E2 formation and impact in inflammation resolution.Authorship 9982729Authorship 998273428713624Chandrasekaran A, Ellett F, Jorgensen J, Irimia DMicrosystems & nanoengineeringTemporal gradients limit the accumulation of neutrophils towards sources of chemoattractant. Microsyst Nanoeng. 2017; 3.Microsyst Nanoeng2017-01-02T00:00:002017Temporal gradients limit the accumulation of neutrophils towards sources of chemoattractant.28720788Sandlin RD, Wong KHK, Boneschansker L, Carey TR, Miller KL, Rose G, Haber DA, Maheswaran S, Irimia D, Stott SL, Toner MScientific reportsPreservative solution that stabilizes erythrocyte morphology and leukocyte viability under ambient conditions. Sci Rep. 2017 07 18; 7(1):5658.Sci Rep2017-07-18T00:00:002017Preservative solution that stabilizes erythrocyte morphology and leukocyte viability under ambient conditions.18375483Russom A, Sethu P, Irimia D, Mindrinos MN, Calvano SE, Garcia I, Finnerty C, Tannahill C, Abouhamze A, Wilhelmy J, López MC, Baker HV, Herndon DN, Lowry SF, Maier RV, Davis RW, Moldawer LL, Tompkins RG, Toner MClinical chemistryMicrofluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients. Clin Chem. 2008 May; 54(5):891-900.Clin Chem2008-03-28T00:00:002008Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients.23110665Bohr S, Patel SJ, Sarin D, Irimia D, Yarmush ML, Berthiaume FWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyResolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. Wound Repair Regen. 2013 Jan-Feb; 21(1):35-43.Wound Repair Regen2012-10-30T00:00:002012Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model.17268618Cheng X, Irimia D, Dixon M, Sekine K, Demirci U, Zamir L, Tompkins RG, Rodriguez W, Toner MLab on a chipA microfluidic device for practical label-free CD4(+) T cell counting of HIV-infected subjects. Lab Chip. 2007 Feb; 7(2):170-8.Lab Chip2006-11-24T00:00:002006A microfluidic device for practical label-free CD4(+) T cell counting of HIV-infected subjects.Authorship 10068813Authorship 1007372428845922Jorfi M, D'Avanzo C, Kim DY, Irimia DAdvanced healthcare materialsThree-Dimensional Models of the Human Brain Development and Diseases. Adv Healthc Mater. 2018 01; 7(1).Adv Healthc Mater2017-08-28T00:00:002017Three-Dimensional Models of the Human Brain Development and Diseases.28781994Jalali F, Ellett F, Irimia DTechnologyRapid antibiotic sensitivity testing in microwell arrays. Technology (Singap World Sci). 2017 06; 5(2):107-114.Technology (Singap World Sci)2017-05-16T00:00:002017Rapid antibiotic sensitivity testing in microwell arrays.Authorship 10090491228877131Inoue Y, Liu YM, Otawara M, Chico Calero I, Stephanie Nam A, Yu YM, Chang P, Butler KL, Nazarian RM, Goverman J, Vakoc BJ, Irimia DJournal of burn care & research : official publication of the American Burn AssociationResolvin D2 Limits Secondary Tissue Necrosis After Burn Wounds in Rats. J Burn Care Res. 2018 04 20; 39(3):423-432.J Burn Care Res2018-04-20T00:00:002018Resolvin D2 Limits Secondary Tissue Necrosis After Burn Wounds in Rats.16450027Irimia D, Liu SY, Tharp WG, Samadani A, Toner M, Poznansky MCLab on a chipMicrofluidic system for measuring neutrophil migratory responses to fast switches of chemical gradients. Lab Chip. 2006 Feb; 6(2):191-8.Lab Chip2005-12-23T00:00:002005Microfluidic system for measuring neutrophil migratory responses to fast switches of chemical gradients.Authorship 10108731228873345Raymond SL, Mathias BJ, Murphy TJ, Rincon JC, López MC, Ungaro R, Ellett F, Jorgensen J, Wynn JL, Baker HV, Moldawer LL, Irimia D, Larson SDTranslational research : the journal of laboratory and clinical medicineNeutrophil chemotaxis and transcriptomics in term and preterm neonates. Transl Res. 2017 12; 190:4-15.Transl Res2017-09-01T00:00:002017Neutrophil chemotaxis and transcriptomics in term and preterm neonates.19023468Agrawal N, Toner M, Irimia DLab on a chipNeutrophil migration assay from a drop of blood. Lab Chip. 2008 Dec; 8(12):2054-61.Lab Chip2008-10-30T00:00:002008Neutrophil migration assay from a drop of blood.19050288Kasuga K, Yang R, Porter TF, Agrawal N, Petasis NA, Irimia D, Toner M, Serhan CNJournal of immunology (Baltimore, Md. : 1950)Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution. J Immunol. 2008 Dec 15; 181(12):8677-87.J Immunol2008-12-15T00:00:002008Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution.Authorship 1013347Reátegui E, Jalali F, Khankhel AH, Wong E, Cho H, Lee J, Serhan CN, Dalli J, Elliott H, Irimia DNature Biomedical EngineeringMicroscale arrays for the profiling of start and stop signals coordinating human-neutrophil swarming. Nature Biomedical Engineering. 2017; 1(7):0094.2017-12-01T00:00:002017Microscale arrays for the profiling of start and stop signals coordinating human-neutrophil swarming22147065Watkins N, Irimia D, Toner M, Bashir RIEEE pulseOn a chip. IEEE Pulse. 2011 Nov; 2(6):19-27.IEEE Pulse2011-11-01T00:00:002011On a chip.16511616Irimia D, Toner MLab on a chipCell handling using microstructured membranes. Lab Chip. 2006 Mar; 6(3):345-52.Lab Chip2006-02-08T00:00:002006Cell handling using microstructured membranes.18584076Park K, Jang J, Irimia D, Sturgis J, Lee J, Robinson JP, Toner M, Bashir RLab on a chip'Living cantilever arrays' for characterization of mass of single live cells in fluids. Lab Chip. 2008 Jul; 8(7):1034-41.Lab Chip2008-06-11T00:00:002008'Living cantilever arrays' for characterization of mass of single live cells in fluids.20023796Irimia D, Mindrinos M, Russom A, Xiao W, Wilhelmy J, Wang S, Heath JD, Kurn N, Tompkins RG, Davis RW, Toner MIntegrative biology : quantitative biosciences from nano to macroGenome-wide transcriptome analysis of 150 cell samples. Integr Biol (Camb). 2009 Jan; 1(1):99-107.Integr Biol (Camb)2008-11-12T00:00:002008Genome-wide transcriptome analysis of 150 cell samples.Authorship 102184510Authorship 1021362629057147Reátegui E, Jalali F, Khankhel AH, Wong E, Cho H, Lee J, Serhan CN, Dalli J, Elliott H, Irimia DNature biomedical engineeringMicroscale arrays for the profiling of start and stop signals coordinating human-neutrophil swarming. Nat Biomed Eng. 2017; 1.Nat Biomed Eng2017-06-30T00:00:002017Microscale arrays for the profiling of start and stop signals coordinating human-neutrophil swarming.29068447Weng L, Ellett F, Edd J, Wong KHK, Uygun K, Irimia D, Stott SL, Toner MLab on a chipA highly-occupied, single-cell trapping microarray for determination of cell membrane permeability. Lab Chip. 2017 11 21; 17(23):4077-4088.Lab Chip2017-11-21T00:00:002017A highly-occupied, single-cell trapping microarray for determination of cell membrane permeability.21757729Yang R, Fredman G, Krishnamoorthy S, Agrawal N, Irimia D, Piomelli D, Serhan CNThe Journal of biological chemistryDecoding functional metabolomics with docosahexaenoyl ethanolamide (DHEA) identifies novel bioactive signals. J Biol Chem. 2011 Sep 09; 286(36):31532-41.J Biol Chem2011-07-12T00:00:002011Decoding functional metabolomics with docosahexaenoyl ethanolamide (DHEA) identifies novel bioactive signals.Daniel IrimiaCapillary Force Valves in Encyclopedia of Micro- and Nanofluidics
edited by Li, DongqingCapillary Force Valves in Encyclopedia of Micro- and Nanofluidics
edited by Li, Dongqing. 2006.2006-01-01T00:00:002006Capillary Force Valves in Encyclopedia of Micro- and Nanofluidics
edited by Li, Dongqing16004567Toner M, Irimia DAnnual review of biomedical engineeringBlood-on-a-chip. Annu Rev Biomed Eng. 2005; 7:77-103.Annu Rev Biomed Eng2005-01-01T00:00:002005Blood-on-a-chip.16689552Irimia D, Geba DA, Toner MAnalytical chemistryUniversal microfluidic gradient generator. Anal Chem. 2006 May 15; 78(10):3472-7.Anal Chem2006-05-15T00:00:002006Universal microfluidic gradient generator.18097410Nagrath S, Sequist LV, Maheswaran S, Bell DW, Irimia D, Ulkus L, Smith MR, Kwak EL, Digumarthy S, Muzikansky A, Ryan P, Balis UJ, Tompkins RG, Haber DA, Toner MNatureIsolation of rare circulating tumour cells in cancer patients by microchip technology. Nature. 2007 Dec 20; 450(7173):1235-9.Nature2007-12-20T00:00:002007Isolation of rare circulating tumour cells in cancer patients by microchip technology.21294269Konry T, Smolina I, Yarmush JM, Irimia D, Yarmush MLSmall (Weinheim an der Bergstrasse, Germany)Ultrasensitive detection of low-abundance surface-marker protein using isothermal rolling circle amplification in a microfluidic nanoliter platform. Small. 2011 Feb 07; 7(3):395-400.Small2010-12-27T00:00:002010Ultrasensitive detection of low-abundance surface-marker protein using isothermal rolling circle amplification in a microfluidic nanoliter platform.22508027Ritch JJ, Valencia A, Alexander J, Sapp E, Gatune L, Sangrey GR, Sinha S, Scherber CM, Zeitlin S, Sadri-Vakili G, Irimia D, Difiglia M, Kegel KBMolecular and cellular neurosciencesMultiple phenotypes in Huntington disease mouse neural stem cells. Mol Cell Neurosci. 2012 May; 50(1):70-81.Mol Cell Neurosci2012-04-06T00:00:002012Multiple phenotypes in Huntington disease mouse neural stem cells.23033492El-Haibi CP, Bell GW, Zhang J, Collmann AY, Wood D, Scherber CM, Csizmadia E, Mariani O, Zhu C, Campagne A, Toner M, Bhatia SN, Irimia D, Vincent-Salomon A, Karnoub AEProceedings of the National Academy of Sciences of the United States of AmericaCritical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17460-5.Proc Natl Acad Sci U S A2012-10-02T00:00:002012Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy.18827015Nery FC, Zeng J, Niland BP, Hewett J, Farley J, Irimia D, Li Y, Wiche G, Sonnenberg A, Breakefield XOJournal of cell scienceTorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton. J Cell Sci. 2008 Oct 15; 121(Pt 20):3476-86.J Cell Sci2008-09-30T00:00:002008TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.20133671Wolfer A, Wittner BS, Irimia D, Flavin RJ, Lupien M, Gunawardane RN, Meyer CA, Lightcap ES, Tamayo P, Mesirov JP, Liu XS, Shioda T, Toner M, Loda M, Brown M, Brugge JS, Ramaswamy SProceedings of the National Academy of Sciences of the United States of AmericaMYC regulation of a "poor-prognosis" metastatic cancer cell state. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3698-703.Proc Natl Acad Sci U S A2010-02-04T00:00:002010MYC regulation of a "poor-prognosis" metastatic cancer cell state.21062900Smolen GA, Zhang J, Zubrowski MJ, Edelman EJ, Luo B, Yu M, Ng LW, Scherber CM, Schott BJ, Ramaswamy S, Irimia D, Root DE, Haber DAGenes & developmentA genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration. Genes Dev. 2010 Dec 01; 24(23):2654-65.Genes Dev2010-11-09T00:00:002010A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration.21874096Prentice-Mott H, Toner M, Irimia DJournal of micromechanics and microengineering : structures, devices, and systemsMicrofluidic proportional flow controller. J Micromech Microeng. 2010 Oct 15; 20(11):1-8.J Micromech Microeng2010-10-15T00:00:002010Microfluidic proportional flow controller.21887438Heo YS, Lee HJ, Hassell BA, Irimia D, Toth TL, Elmoazzen H, Toner MLab on a chipControlled loading of cryoprotectants (CPAs) to oocyte with linear and complex CPA profiles on a microfluidic platform. Lab Chip. 2011 Oct 21; 11(20):3530-7.Lab Chip2011-09-01T00:00:002011Controlled loading of cryoprotectants (CPAs) to oocyte with linear and complex CPA profiles on a microfluidic platform.Authorship 1035522229286475Ellett F, Irimia DJournal of visualized experiments : JoVEMicrostructured Devices for Optimized Microinjection and Imaging of Zebrafish Larvae. J Vis Exp. 2017 12 08; (130).J Vis Exp2017-12-08T00:00:002017Microstructured Devices for Optimized Microinjection and Imaging of Zebrafish Larvae.19593749Russom A, Irimia D, Toner MElectrophoresisChemical gradient-mediated melting curve analysis for genotyping of SNPs. Electrophoresis. 2009 Jul; 30(14):2536-43.Electrophoresis2009-07-01T00:00:002009Chemical gradient-mediated melting curve analysis for genotyping of SNPs.LPL5LukeLeeLuke Pyung-Se Lee, Ph.D.165825Lee, LukeProfessor of Medicine18030401Irimia D, Charras G, Agrawal N, Mitchison T, Toner MLab on a chipPolar stimulation and constrained cell migration in microfluidic channels. Lab Chip. 2007 Dec; 7(12):1783-90.Lab Chip2007-09-04T00:00:002007Polar stimulation and constrained cell migration in microfluidic channels.Authorship 1041378529382882Boneschansker L, Jorgensen J, Ellett F, Briscoe DM, Irimia DScientific reportsConvergent and Divergent Migratory Patterns of Human Neutrophils inside Microfluidic Mazes. Sci Rep. 2018 01 30; 8(1):1887.Sci Rep2018-01-30T00:00:002018Convergent and Divergent Migratory Patterns of Human Neutrophils inside Microfluidic Mazes.19789737Irimia DLab on a chipCutting edge: electronic counting of white blood cells. Lab Chip. 2009 Oct 21; 9(20):2875-6.Lab Chip2009-08-28T00:00:002009Cutting edge: electronic counting of white blood cells.20802500Kotz KT, Xiao W, Miller-Graziano C, Qian WJ, Russom A, Warner EA, Moldawer LL, De A, Bankey PE, Petritis BO, Camp DG, Rosenbach AE, Goverman J, Fagan SP, Brownstein BH, Irimia D, Xu W, Wilhelmy J, Mindrinos MN, Smith RD, Davis RW, Tompkins RG, Toner MNature medicineClinical microfluidics for neutrophil genomics and proteomics. Nat Med. 2010 Sep; 16(9):1042-7.Nat Med2010-08-29T00:00:002010Clinical microfluidics for neutrophil genomics and proteomics.21538345Hoerning A, Koss K, Datta D, Boneschansker L, Jones CN, Wong IY, Irimia D, Calzadilla K, Benitez F, Hoyer PF, Harmon WE, Briscoe DMEuropean journal of immunologySubsets of human CD4(+) regulatory T cells express the peripheral homing receptor CXCR3. Eur J Immunol. 2011 Aug; 41(8):2291-302.Eur J Immunol2011-06-24T00:00:002011Subsets of human CD4(+) regulatory T cells express the peripheral homing receptor CXCR3.Authorship 1044223529402979Jorfi M, D'Avanzo C, Tanzi RE, Kim DY, Irimia DScientific reportsHuman Neurospheroid Arrays for In Vitro Studies of Alzheimer's Disease. Sci Rep. 2018 02 05; 8(1):2450.Sci Rep2018-02-05T00:00:002018Human Neurospheroid Arrays for In Vitro Studies of Alzheimer's Disease.11916845Irimia D, Karlsson JOBiophysical journalKinetics and mechanism of intercellular ice propagation in a micropatterned tissue construct. Biophys J. 2002 Apr; 82(4):1858-68.Biophys J2002-04-01T00:00:002002Kinetics and mechanism of intercellular ice propagation in a micropatterned tissue construct.Authorship 100312116493048Vianello F, Papeta N, Chen T, Kraft P, White N, Hart WK, Kircher MF, Swart E, Rhee S, Palù G, Irimia D, Toner M, Weissleder R, Poznansky MCJournal of immunology (Baltimore, Md. : 1950)Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control. J Immunol. 2006 Mar 01; 176(5):2902-14.J Immunol2006-03-01T00:00:002006Murine B16 melanomas expressing high levels of the chemokine stromal-derived factor-1/CXCL12 induce tumor-specific T cell chemorepulsion and escape from immune control.Irimia, D., Karlsson, J.O.MJournal of Biomedical MicrodevicesDevelopment of a Cell Patterning Technique Using Poly(Ethylene Glycol) Disilane. Journal of Biomedical Microdevices. 2003; 5(3):185-194.2003-01-01T00:00:002003Development of a Cell Patterning Technique Using Poly(Ethylene Glycol) Disilane