TS23ToshihiroShiodaToshihiro Shioda, M.D., Ph.D.42.37730000000000-71.0525000000000081538Shioda, Toshihiro617/726-5625Associate Professor of Medicinecatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson10985851Sado T, Fenner MH, Tan SS, Tam P, Shioda T, Li EDevelopmental biologyX inactivation in the mouse embryo deficient for Dnmt1: distinct effect of hypomethylation on imprinted and random X inactivation. Dev Biol. 2000 Sep 15; 225(2):294-303.Dev Biol2000-09-15T00:00:002000X inactivation in the mouse embryo deficient for Dnmt1: distinct effect of hypomethylation on imprinted and random X inactivation.Authorship 10464484Authorship 10453981329453314Aceto N, Bardia A, Wittner BS, Donaldson MC, O'Keefe R, Engstrom A, Bersani F, Zheng Y, Comaills V, Niederhoffer K, Zhu H, Mackenzie O, Shioda T, Sgroi D, Kapur R, Ting DT, Moy B, Ramaswamy S, Toner M, Haber DA, Maheswaran SMolecular cancer research : MCRAR Expression in Breast Cancer CTCs Associates with Bone Metastases. Mol Cancer Res. 2018 04; 16(4):720-727.Mol Cancer Res2018-02-16T00:00:002018AR Expression in Breast Cancer CTCs Associates with Bone Metastases.29420656Owa C, Poulin M, Yan L, Shioda TPloS oneTechnical adequacy of bisulfite sequencing and pyrosequencing for detection of mitochondrial DNA methylation: Sources and avoidance of false-positive detection. PLoS One. 2018; 13(2):e0192722.PLoS One2018-02-08T00:00:002018Technical adequacy of bisulfite sequencing and pyrosequencing for detection of mitochondrial DNA methylation: Sources and avoidance of false-positive detection.9311801Kato A, Kiyotani K, Sakai Y, Yoshida T, Shioda T, Nagai YJournal of virologyImportance of the cysteine-rich carboxyl-terminal half of V protein for Sendai virus pathogenesis. J Virol. 1997 Oct; 71(10):7266-72.J Virol1997-10-01T00:00:001997Importance of the cysteine-rich carboxyl-terminal half of V protein for Sendai virus pathogenesis.10516032Kato A, Kiyotani K, Hasan MK, Shioda T, Sakai Y, Yoshida T, Nagai YJournal of virologySendai virus gene start signals are not equivalent in reinitiation capacity: moderation at the fusion protein gene. J Virol. 1999 Nov; 73(11):9237-46.J Virol1999-11-01T00:00:001999Sendai virus gene start signals are not equivalent in reinitiation capacity: moderation at the fusion protein gene.10636916de Caestecker MP, Yahata T, Wang D, Parks WT, Huang S, Hill CS, Shioda T, Roberts AB, Lechleider RJThe Journal of biological chemistryThe Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain. J Biol Chem. 2000 Jan 21; 275(3):2115-22.J Biol Chem2000-01-21T00:00:002000The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain.10722728Yahata T, de Caestecker MP, Lechleider RJ, Andriole S, Roberts AB, Isselbacher KJ, Shioda TThe Journal of biological chemistryThe MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. J Biol Chem. 2000 Mar 24; 275(12):8825-34.J Biol Chem2000-03-24T00:00:002000The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors.Authorship 106664317975144Wang Z, Dahiya S, Provencher H, Muir B, Carney E, Coser K, Shioda T, Ma XJ, Sgroi DCClinical cancer research : an official journal of the American Association for Cancer ResearchThe prognostic biomarkers HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer. Clin Cancer Res. 2007 Nov 01; 13(21):6327-34.Clin Cancer Res2007-11-01T00:00:002007The prognostic biomarkers HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer.18559533Montagut C, Sharma SV, Shioda T, McDermott U, Ulman M, Ulkus LE, Dias-Santagata D, Stubbs H, Lee DY, Singh A, Drew L, Haber DA, Settleman JCancer researchElevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res. 2008 Jun 15; 68(12):4853-61.Cancer Res2008-06-15T00:00:002008Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma.20418860Stadtfeld M, Apostolou E, Akutsu H, Fukuda A, Follett P, Natesan S, Kono T, Shioda T, Hochedlinger KNatureAberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature. 2010 May 13; 465(7295):175-81.Nature2010-04-25T00:00:002010Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells.17178859Yang C, Trent S, Ionescu-Tiba V, Lan L, Shioda T, Sgroi D, Schmidt EVCancer researchIdentification of cyclin D1- and estrogen-regulated genes contributing to breast carcinogenesis and progression. Cancer Res. 2006 Dec 15; 66(24):11649-58.Cancer Res2006-12-15T00:00:002006Identification of cyclin D1- and estrogen-regulated genes contributing to breast carcinogenesis and progression.17047080Hur J, Bell DW, Dean KL, Coser KR, Hilario PC, Okimoto RA, Tobey EM, Smith SL, Isselbacher KJ, Shioda TCancer researchRegulation of expression of BIK proapoptotic protein in human breast cancer cells: p53-dependent induction of BIK mRNA by fulvestrant and proteasomal degradation of BIK protein. Cancer Res. 2006 Oct 15; 66(20):10153-61.Cancer Res2006-10-15T00:00:002006Regulation of expression of BIK proapoptotic protein in human breast cancer cells: p53-dependent induction of BIK mRNA by fulvestrant and proteasomal degradation of BIK protein.19797399Peluso JJ, Gawkowska A, Liu X, Shioda T, Pru JKEndocrinologyProgesterone receptor membrane component-1 regulates the development and Cisplatin sensitivity of human ovarian tumors in athymic nude mice. Endocrinology. 2009 Nov; 150(11):4846-54.Endocrinology2009-10-01T00:00:002009Progesterone receptor membrane component-1 regulates the development and Cisplatin sensitivity of human ovarian tumors in athymic nude mice.Authorship 1067680229782583Mitsunaga S, Shioda TStem cell investigationEvolutionarily diverse mechanisms of germline specification among mammals: what about us? Stem Cell Investig. 2018; 5:12.Stem Cell Investig2018-04-24T00:00:002018Evolutionarily diverse mechanisms of germline specification among mammals: what about us?2829426Shioda T, Wakao S, Suzu S, Shibuta HVirologyDifferences in bovine parainfluenza 3 virus variants studied by sequencing of the genes of viral envelope proteins. Virology. 1988 Feb; 162(2):388-96.Virology1988-02-01T00:00:001988Differences in bovine parainfluenza 3 virus variants studied by sequencing of the genes of viral envelope proteins.Authorship 1071755429860300Shoucri BM, Hung VT, Chamorro-García R, Shioda T, Blumberg BEndocrinologyRetinoid X Receptor Activation During Adipogenesis of Female Mesenchymal Stem Cells Programs a Dysfunctional Adipocyte. Endocrinology. 2018 08 01; 159(8):2863-2883.Endocrinology2018-08-01T00:00:002018Retinoid X Receptor Activation During Adipogenesis of Female Mesenchymal Stem Cells Programs a Dysfunctional Adipocyte.Authorship 117155222035958Walker AK, Jacobs RL, Watts JL, Rottiers V, Jiang K, Finnegan DM, Shioda T, Hansen M, Yang F, Niebergall LJ, Vance DE, Tzoneva M, Hart AC, Näär AMCellA conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell. 2011 Nov 11; 147(4):840-52.Cell2011-10-27T00:00:002011A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans.17287200Yi X, Bouley R, Lin HY, Bechoua S, Sun TX, Del Re E, Shioda T, Raychowdhury MK, Lu HA, Abou-Samra AB, Brown D, Ausiello DAAmerican journal of physiology. Renal physiologyAlix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R. Am J Physiol Renal Physiol. 2007 May; 292(5):F1303-13.Am J Physiol Renal Physiol2007-02-06T00:00:002007Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R.18187554Yang D, Guo J, Divieti P, Shioda T, Bringhurst FREndocrinologyCBP/p300-interacting protein CITED1 modulates parathyroid hormone regulation of osteoblastic differentiation. Endocrinology. 2008 Apr; 149(4):1728-35.Endocrinology2008-01-10T00:00:002008CBP/p300-interacting protein CITED1 modulates parathyroid hormone regulation of osteoblastic differentiation.21292820Ishii Y, Papa L, Bahadur U, Yue Z, Aguirre-Ghiso J, Shioda T, Waxman S, Germain DClinical cancer research : an official journal of the American Association for Cancer ResearchBortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of the estrogen receptor, which leads to a proapoptotic unfolded protein response. Clin Cancer Res. 2011 Apr 15; 17(8):2292-300.Clin Cancer Res2011-02-03T00:00:002011Bortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of the estrogen receptor, which leads to a proapoptotic unfolded protein response.Authorship 114041419118578Smith SL, Shioda TJournal of virological methodsAdvantages of COS-1 monkey kidney epithelial cells as packaging host for small-volume production of high-quality recombinant lentiviruses. J Virol Methods. 2009 Apr; 157(1):47-54.J Virol Methods2009-01-14T00:00:002009Advantages of COS-1 monkey kidney epithelial cells as packaging host for small-volume production of high-quality recombinant lentiviruses.Authorship 10877992Authorship 10880172Authorship 10878006Authorship 10879312Authorship 10879293Authorship 10879303Authorship 108807320Authorship 108819738892864Hu H, Shioda T, Moriya C, Xin X, Hasan MK, Miyake K, Shimada T, Nagai YJournal of virologyInfectivities of human and other primate lentiviruses are activated by desialylation of the virion surface. J Virol. 1996 Nov; 70(11):7462-70.J Virol1996-11-01T00:00:001996Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface.9367367Hasan MK, Kato A, Shioda T, Sakai Y, Yu D, Nagai YThe Journal of general virologyCreation of an infectious recombinant Sendai virus expressing the firefly luciferase gene from the 3' proximal first locus. J Gen Virol. 1997 Nov; 78 ( Pt 11):2813-20.J Gen Virol1997-11-01T00:00:001997Creation of an infectious recombinant Sendai virus expressing the firefly luciferase gene from the 3' proximal first locus.9505968Xin X, Shioda T, Fukushima M, Hu H, Oka S, Iwamoto A, Nagai YArchives of virologyFacilitation of HIV-1 isolation from patients by neuraminidase. Arch Virol. 1998; 143(1):85-95.Arch Virol1998-01-01T00:00:001998Facilitation of HIV-1 isolation from patients by neuraminidase.1909875Aoki N, Shioda T, Satoh H, Shibuta HAIDS (London, England)Syncytium formation of human and non-human cells by recombinant vaccinia viruses carrying the HIV env gene and human CD4 gene. AIDS. 1991 Jul; 5(7):871-5.AIDS1991-07-01T00:00:001991Syncytium formation of human and non-human cells by recombinant vaccinia viruses carrying the HIV env gene and human CD4 gene.8018387Oka S, Ida S, Shioda T, Takebe Y, Kobayashi N, Shibuya Y, Ohyama K, Momota K, Kimura S, Shimada KAIDS research and human retrovirusesGenetic analysis of HIV-1 during rapid progression to AIDS in an apparently healthy man. AIDS Res Hum Retroviruses. 1994 Mar; 10(3):271-7.AIDS Res Hum Retroviruses1994-03-01T00:00:001994Genetic analysis of HIV-1 during rapid progression to AIDS in an apparently healthy man.17373935Song H, Nakayama EE, Likanonsakul S, Wasi C, Iwamoto A, Shioda TInternational journal of immunogeneticsA three-base-deletion polymorphism in the upstream non-coding region of human interleukin 7 (IL-7) gene could enhance levels of IL-7 expression. Int J Immunogenet. 2007 Apr; 34(2):107-13.Int J Immunogenet2007-04-01T00:00:002007A three-base-deletion polymorphism in the upstream non-coding region of human interleukin 7 (IL-7) gene could enhance levels of IL-7 expression.30111657Janesick A, Tang W, Shioda T, Blumberg BDevelopment (Cambridge, England)RAR? is required for mesodermal gene expression prior to gastrulation in Xenopus. Development. 2018 09 17; 145(18).Development2018-09-17T00:00:002018RAR? is required for mesodermal gene expression prior to gastrulation in Xenopus.10823849Nakayama EE, Hoshino Y, Xin X, Liu H, Goto M, Watanabe N, Taguchi H, Hitani A, Kawana-Tachikawa A, Fukushima M, Yamada K, Sugiura W, Oka SI, Ajisawa A, Sato H, Takebe Y, Nakamura T, Nagai Y, Iwamoto A, Shioda TJournal of virologyPolymorphism in the interleukin-4 promoter affects acquisition of human immunodeficiency virus type 1 syncytium-inducing phenotype. J Virol. 2000 Jun; 74(12):5452-9.J Virol2000-06-01T00:00:002000Polymorphism in the interleukin-4 promoter affects acquisition of human immunodeficiency virus type 1 syncytium-inducing phenotype.30127506Di Stefano B, Ueda M, Sabri S, Brumbaugh J, Huebner AJ, Sahakyan A, Clement K, Clowers KJ, Erickson AR, Shioda K, Gygi SP, Gu H, Shioda T, Meissner A, Takashima Y, Plath K, Hochedlinger KNature methodsReduced MEK inhibition preserves genomic stability in naive human embryonic stem cells. Nat Methods. 2018 09; 15(9):732-740.Nat Methods2018-08-20T00:00:002018Reduced MEK inhibition preserves genomic stability in naive human embryonic stem cells.Authorship 108901313Authorship 1181633031615Suzu S, Sakai Y, Shioda T, Shibuta HNucleic acids researchNucleotide sequence of the bovine parainfluenza 3 virus genome: the genes of the F and HN glycoproteins. Nucleic Acids Res. 1987 Apr 10; 15(7):2945-58.Nucleic Acids Res1987-04-10T00:00:001987Nucleotide sequence of the bovine parainfluenza 3 virus genome: the genes of the F and HN glycoproteins.Authorship 1091714430178259Poulin M, Zhou JY, Yan L, Shioda TMethods in molecular biology (Clifton, N.J.)Pyrosequencing Methylation Analysis. Methods Mol Biol. 2018; 1856:283-296.Methods Mol Biol2018-01-01T00:00:002018Pyrosequencing Methylation Analysis.21536587Jacobsen JC, Gregory GC, Woda JM, Thompson MN, Coser KR, Murthy V, Kohane IS, Gusella JF, Seong IS, MacDonald ME, Shioda T, Lee JMHuman molecular geneticsHD CAG-correlated gene expression changes support a simple dominant gain of function. Hum Mol Genet. 2011 Jul 15; 20(14):2846-60.Hum Mol Genet2011-05-02T00:00:002011HD CAG-correlated gene expression changes support a simple dominant gain of function.21840924Fossale E, Seong IS, Coser KR, Shioda T, Kohane IS, Wheeler VC, Gusella JF, MacDonald ME, Lee JMHuman molecular geneticsDifferential effects of the Huntington's disease CAG mutation in striatum and cerebellum are quantitative not qualitative. Hum Mol Genet. 2011 Nov 01; 20(21):4258-67.Hum Mol Genet2011-08-12T00:00:002011Differential effects of the Huntington's disease CAG mutation in striatum and cerebellum are quantitative not qualitative.23144751Taylor JA, Richter CA, Suzuki A, Watanabe H, Iguchi T, Coser KR, Shioda T, vom Saal FSPloS oneDose-related estrogen effects on gene expression in fetal mouse prostate mesenchymal cells. PLoS One. 2012; 7(10):e48311.PLoS One2012-10-29T00:00:002012Dose-related estrogen effects on gene expression in fetal mouse prostate mesenchymal cells.23245996Corcoran RB, Cheng KA, Hata AN, Faber AC, Ebi H, Coffee EM, Greninger P, Brown RD, Godfrey JT, Cohoon TJ, Song Y, Lifshits E, Hung KE, Shioda T, Dias-Santagata D, Singh A, Settleman J, Benes CH, Mino-Kenudson M, Wong KK, Engelman JACancer cellSynthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models. Cancer Cell. 2013 Jan 14; 23(1):121-8.Cancer Cell2012-12-13T00:00:002012Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models.7991557Shioda T, Ohta T, Isselbacher KJ, Rhoads DBProceedings of the National Academy of Sciences of the United States of AmericaDifferentiation-dependent expression of the Na+/glucose cotransporter (SGLT1) in LLC-PK1 cells: role of protein kinase C activation and ongoing transcription. Proc Natl Acad Sci U S A. 1994 Dec 06; 91(25):11919-23.Proc Natl Acad Sci U S A1994-12-06T00:00:001994Differentiation-dependent expression of the Na+/glucose cotransporter (SGLT1) in LLC-PK1 cells: role of protein kinase C activation and ongoing transcription.8337822LeGuern M, Shioda T, Levy JA, Cheng-Mayer CVirologySingle amino acid change in Tat determines the different rates of replication of two sequential HIV-1 isolates. Virology. 1993 Aug; 195(2):441-7.Virology1993-08-01T00:00:001993Single amino acid change in Tat determines the different rates of replication of two sequential HIV-1 isolates.Authorship 114424820080567Hayashida T, Takahashi F, Chiba N, Brachtel E, Takahashi M, Godin-Heymann N, Gross KW, Vivanco Md, Wijendran V, Shioda T, Sgroi D, Donahoe PK, Maheswaran SProceedings of the National Academy of Sciences of the United States of AmericaHOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis. Proc Natl Acad Sci U S A. 2010 Jan 19; 107(3):1100-5.Proc Natl Acad Sci U S A2009-12-28T00:00:002009HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis.Authorship 1120992530557361Taylor JA, Sommerfeld-Sager JM, Meng CX, Nagel SC, Shioda T, Vom Saal FSPloS oneReduced body weight at weaning followed by increased post-weaning growth rate interacts with part-per-trillion fetal serum concentrations of bisphenol A (BPA) to impair glucose tolerance in male mice. PLoS One. 2018; 13(12):e0208846.PLoS One2018-12-17T00:00:002018Reduced body weight at weaning followed by increased post-weaning growth rate interacts with part-per-trillion fetal serum concentrations of bisphenol A (BPA) to impair glucose tolerance in male mice.9683535Li H, Ahmed NU, Fenner MH, Ueda M, Isselbacher KJ, Shioda TExperimental cell researchRegulation of expression of MSG1 melanocyte-specific nuclear protein in human melanocytes and melanoma cells. Exp Cell Res. 1998 Aug 01; 242(2):478-86.Exp Cell Res1998-08-01T00:00:001998Regulation of expression of MSG1 melanocyte-specific nuclear protein in human melanocytes and melanoma cells.10906483Andrews JE, O'Neill MJ, Binder M, Shioda T, Sinclair AHMechanisms of developmentIsolation and expression of a novel member of the CITED family. Mech Dev. 2000 Jul; 95(1-2):305-8.Mech Dev2000-07-01T00:00:002000Isolation and expression of a novel member of the CITED family.15843474Plisov S, Tsang M, Shi G, Boyle S, Yoshino K, Dunwoodie SL, Dawid IB, Shioda T, Perantoni AO, de Caestecker MPJournal of the American Society of Nephrology : JASNCited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning. J Am Soc Nephrol. 2005 Jun; 16(6):1632-44.J Am Soc Nephrol2005-04-20T00:00:002005Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning.21172805Dittmer S, Kovacs Z, Yuan SH, Siszler G, Kögl M, Summer H, Geerts A, Golz S, Shioda T, Methner AJournal of cell scienceTOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex. J Cell Sci. 2011 Jan 15; 124(Pt 2):252-60.J Cell Sci2010-12-15T00:00:002010TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex.Authorship 1129371530688291Mitsunaga S, Shioda K, Isselbacher KJ, Hanna JH, Shioda TJournal of visualized experiments : JoVEGeneration of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells. J Vis Exp. 2019 01 11; (143).J Vis Exp2019-01-11T00:00:002019Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells.Authorship 11393141430819896Zheng Y, Comaills V, Burr R, Boulay G, Miyamoto DT, Wittner BS, Emmons E, Sil S, Koulopoulos MW, Broderick KT, Tai E, Rengarajan S, Kulkarni AS, Shioda T, Wu CL, Ramaswamy S, Ting DT, Toner M, Rivera MN, Maheswaran S, Haber DAProceedings of the National Academy of Sciences of the United States of AmericaCOX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis. Proc Natl Acad Sci U S A. 2019 03 19; 116(12):5223-5232.Proc Natl Acad Sci U S A2019-02-28T00:00:002019COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis.Authorship 1133387D005854AnatomyConcepts & Ideas3666270.717746Germ CellsMGH Cancer Center ResearchD057026Anatomy70517020.43642Induced Pluripotent Stem CellsD004967Chemicals & Drugs65515610.578681EstrogensD052244Chemicals & Drugs882370.763146Endocrine DisruptorsD058732Anatomy48670.939822Embryoid BodiesGeneticsMedicinePediatricsPMESurgeryHematology/OncologyBoston Children's HospitalDana-Farber Cancer InstituteHarvard Medical SchoolHarvard T.H. Chan School of Public HealthMassachusetts General HospitalMassachusetts Institute of TechnologySSP1ShivPillaiShiv S. Pillai, M.D., Ph.D.42.37730000000000-71.052500000000007602Pillai, ShivProfessor of MedicineAL118AliceLanAlice Lan, Ph.D.42.37730000000000-71.0525000000000075877Lan, AliceInstructor in MedicineDAH2DanielHaberDaniel Arie Haber, M.D., Ph.D.42.37730000000000-71.0525000000000010825Haber, DanielKurt J. Isselbacher Professor of Oncology11162selected publications2.783730.000907572738research areas0.9808290.019059579coauthor of48.225214.513560similar toKW36KonradHochedlingerKonrad Hochedlinger, Ph.D.42.36125700000000-71.0655270000000079233Hochedlinger, KonradProfessor of GeneticsNJD1NicholasDysonNicholas John Dyson, Ph.D.42.37730000000000-71.052500000000005607Dyson, NicholasProfessor of MedicineCJT1CliffordTabinClifford J. Tabin, Ph.D.42.33837200000000-71.1032690000000073820Tabin, CliffordGeorge Jacob and Jacqueline Hazel Leder Professor of GeneticsAB131AndreaBaccarelliAndrea Baccarelli, M.D., Ph.D.42.34434300000000-71.1036980000000068960Baccarelli, AndreaDean of the FacultyAB15AndreBernardsAndre Bernards, Ph.D.42.37730000000000-71.0525000000000010942Bernards, AndreCorresponding Member of the Faculty of MedicineSHO1StuartOrkinStuart Holland Orkin, M.D.42.33789600000000-71.1072493000000056992Orkin, StuartDavid G. Nathan Distinguished Professor of PediatricsGQD1GeorgeDaleyGeorge Quentin Daley, M.D., Ph.D.42.33812600000000-71.1049210000000062Daley, GeorgeCaroline Shields Walker Professor of MedicineBW17BenWittnerBen Wittner, Ph.D.42.36125700000000-71.0655270000000061379Wittner, BenInstructor in MedicineDCP1DavidPageDavid C. Page, M.D.42.36272860000000-71.0843313000000065134Page, DavidMember of the Harvard-MIT Health Sciences and Technology FacultySM9ShyamalaMaheswaranShyamala Maheswaran, Ph.D.42.37730000000000-71.0525000000000010138Maheswaran, ShyamalaProfessor of SurgeryALF1A.FrazierA. Lindsay Frazier, M.D.42.33789600000000-71.1072493000000014157Frazier, A.Professor of PediatricsAuthorship 11678841431253781Tajima K, Matsuda S, Yae T, Drapkin BJ, Morris R, Boukhali M, Niederhoffer K, Comaills V, Dubash T, Nieman L, Guo H, Magnus NKC, Dyson N, Shioda T, Haas W, Haber DA, Maheswaran SNature communicationsSETD1A protects from senescence through regulation of the mitotic gene expression program. Nat Commun. 2019 06 28; 10(1):2854.Nat Commun2019-06-28T00:00:002019SETD1A protects from senescence through regulation of the mitotic gene expression program.Authorship 1470671Authorship 1189356331506492Diaz-Castillo C, Chamorro-Garcia R, Shioda T, Blumberg BScientific reportsTransgenerational Self-Reconstruction of Disrupted Chromatin Organization After Exposure To An Environmental Stressor in Mice. Sci Rep. 2019 09 10; 9(1):13057.Sci Rep2019-09-10T00:00:002019Transgenerational Self-Reconstruction of Disrupted Chromatin Organization After Exposure To An Environmental Stressor in Mice.Authorship 1147885true1Associate Professor of MedicineAssociate Professor of Medicinetrue1Kurt J. Isselbacher Professor of OncologyKurt J. Isselbacher Professor of Oncologytrue1Professor of MedicineProfessor of Medicinetrue1Instructor in MedicineInstructor in Medicinetrue1Instructor in MedicineInstructor in MedicineAuthorship 1491096Authorship 12794511Authorship 1219183731063509Sakurai K, Shioda K, Eguchi A, Watanabe M, Miyaso H, Mori C, Shioda TPloS oneDNA methylome of human neonatal umbilical cord: Enrichment of differentially methylated regions compared to umbilical cord blood DNA at transcription factor genes involved in body patterning and effects of maternal folate deficiency or children's sex. PLoS One. 2019; 14(5):e0214307.PLoS One2019-05-07T00:00:002019DNA methylome of human neonatal umbilical cord: Enrichment of differentially methylated regions compared to umbilical cord blood DNA at transcription factor genes involved in body patterning and effects of maternal folate deficiency or children's sex.Authorship 1281623Authorship 1373397Authorship 1327372Authorship 1422546Authorship 1495311true1Corresponding Member of the Faculty of MedicineCorresponding Member of the Faculty of Medicinetrue1Professor of SurgeryProfessor of SurgeryAuthorship 1280411532852762Mitsunaga S, Shioda K, Hanna JH, Isselbacher KJ, Shioda TMethods in molecular biology (Clifton, N.J.)Production and Analysis of Human Primordial Germ Cell-Like Cells. Methods Mol Biol. 2021; 2195:125-145.Methods Mol Biol2021-01-01T00:00:002021Production and Analysis of Human Primordial Germ Cell-Like Cells.BCMPAuthorship 1496384Authorship 1303978733170207Shioda K, Odajima J, Kobayashi M, Kobayashi M, Cordazzo B, Isselbacher KJ, Shioda TEndocrinologyTranscriptomic and Epigenetic Preservation of Genetic Sex Identity in Estrogen-feminized Male Chicken Embryonic Gonads. Endocrinology. 2021 01 01; 162(1).Endocrinology2021-01-01T00:00:002021Transcriptomic and Epigenetic Preservation of Genetic Sex Identity in Estrogen-feminized Male Chicken Embryonic Gonads.Authorship 13241447Authorship 1323466733513614Shioda K, Odajima J, Kobayashi M, Kobayashi M, Cordazzo B, Isselbacher KJ, Shioda TEndocrinologyTranscriptomic and Epigenetic Preservation of Genetic Sex Identity in Estrogen-feminized Male Chicken Embryonic Gonads. Endocrinology. 2021 Jan 01; 162(1).Endocrinology2021-01-01T00:00:002021Transcriptomic and Epigenetic Preservation of Genetic Sex Identity in Estrogen-feminized Male Chicken Embryonic Gonads.33513616Shioda K, Odajima J, Kobayashi M, Kobayashi M, Cordazzo B, Isselbacher KJ, Shioda TEndocrinologyTranscriptomic and Epigenetic Preservation of Genetic Sex Identity in Estrogen-feminized Male Chicken Embryonic Gonads. Endocrinology. 2021 Jan 01; 162(1).Endocrinology2021-01-01T00:00:002021Transcriptomic and Epigenetic Preservation of Genetic Sex Identity in Estrogen-feminized Male Chicken Embryonic Gonads.2025-06-30BLUMBERG, BRUCE ;SHIODA, TOSHIHIRO2020-09-16Interactions between prenatal obesogen exposure and Total Western diet lead to a transgenerational thrifty phenotype: functional and epigenomic analysis of effects in fat and liverR01ES031139Co-Principal InvestigatorAuthorship 1986832Authorship 15294221Authorship 1869873Authorship 2155111Authorship 17028512Authorship 1580367Authorship 1382298734360875Hu WY, Hu DP, Xie L, Nonn L, Lu R, Abern M, Shioda T, Prins GSInternational journal of molecular sciencesKeratin Profiling by Single-Cell RNA-Sequencing Identifies Human Prostate Stem Cell Lineage Hierarchy and Cancer Stem-Like Cells. Int J Mol Sci. 2021 Jul 28; 22(15).Int J Mol Sci2021-07-28T00:00:002021Keratin Profiling by Single-Cell RNA-Sequencing Identifies Human Prostate Stem Cell Lineage Hierarchy and Cancer Stem-Like Cells.Authorship 1412380334734245Lim J, Ramesh A, Shioda T, Leon Parada K, Luderer UEndocrinologySex Differences in Embryonic Gonad Transcriptomes and Benzo[a]pyrene Metabolite Levels After Transplacental Exposure. Endocrinology. 2022 01 01; 163(1).Endocrinology2022-01-01T00:00:002022Sex Differences in Embryonic Gonad Transcriptomes and Benzo[a]pyrene Metabolite Levels After Transplacental Exposure.Authorship 1423154434975759Mohajer N, Joloya EM, Seo J, Shioda T, Blumberg BFrontiers in endocrinologyEpigenetic Transgenerational Inheritance of the Effects of Obesogen Exposure. Front Endocrinol (Lausanne). 2021; 12:787580.Front Endocrinol (Lausanne)2021-12-16T00:00:002021Epigenetic Transgenerational Inheritance of the Effects of Obesogen Exposure.Authorship 14296341635148847Kobayashi M, Kobayashi M, Odajima J, Shioda K, Hwang YS, Sasaki K, Chatterjee P, Kramme C, Kohman RE, Church GM, Loehr AR, Weiss RS, Jüppner H, Gell JJ, Lau CC, Shioda TStem cell reportsExpanding homogeneous culture of human primordial germ cell-like cells maintaining germline features without serum or feeder layers. Stem Cell Reports. 2022 03 08; 17(3):507-521.Stem Cell Reports2022-02-10T00:00:002022Expanding homogeneous culture of human primordial germ cell-like cells maintaining germline features without serum or feeder layers.Authorship 14385233Authorship 1436000435208169Shioda K, Odajima J, Blumberg B, Shioda TMetabolitesTransgenerational Transcriptomic and DNA Methylome Profiling of Mouse Fetal Testicular Germline and Somatic Cells after Exposure of Pregnant Mothers to Tributyltin, a Potent Obesogen. Metabolites. 2022 Jan 20; 12(2).Metabolites2022-01-20T00:00:002022Transgenerational Transcriptomic and DNA Methylome Profiling of Mouse Fetal Testicular Germline and Somatic Cells after Exposure of Pregnant Mothers to Tributyltin, a Potent Obesogen.35208177Taylor JA, Coe BL, Shioda T, Vom Saal FSMetabolitesThe Crowded Uterine Horn Mouse Model for Examining Postnatal Metabolic Consequences of Intrauterine Growth Restriction vs. Macrosomia in Siblings. Metabolites. 2022 Jan 22; 12(2).Metabolites2022-01-22T00:00:002022The Crowded Uterine Horn Mouse Model for Examining Postnatal Metabolic Consequences of Intrauterine Growth Restriction vs. Macrosomia in Siblings.Authorship 14978661936055194Zheng Y, Yan RZ, Sun S, Kobayashi M, Xiang L, Yang R, Goedel A, Kang Y, Xue X, Esfahani SN, Liu Y, Resto Irizarry AM, Wu W, Li Y, Ji W, Niu Y, Chien KR, Li T, Shioda T, Fu JCell stem cellSingle-cell analysis of embryoids reveals lineage diversification roadmaps of early human development. Cell Stem Cell. 2022 09 01; 29(9):1402-1419.e8.Cell Stem Cell2022-09-01T00:00:002022Single-cell analysis of embryoids reveals lineage diversification roadmaps of early human development.true1Member of the Harvard-MIT Health Sciences and Technology FacultyMember of the Harvard-MIT Health Sciences and Technology FacultyAuthorship 152435612Authorship 1525496536740725Chang RC, Joloya EM, Li Z, Shoucri BM, Shioda T, Blumberg BEndocrinologymiR-223 Plays a Key Role in Obesogen-Enhanced Adipogenesis in Mesenchymal Stem Cells and in Transgenerational Obesity. Endocrinology. 2023 03 13; 164(5).Endocrinology2023-03-13T00:00:002023miR-223 Plays a Key Role in Obesogen-Enhanced Adipogenesis in Mesenchymal Stem Cells and in Transgenerational Obesity.36803359Pierson Smela MD, Kramme CC, Fortuna PRJ, Adams JL, Su R, Dong E, Kobayashi M, Brixi G, Kavirayuni VS, Tysinger E, Kohman RE, Shioda T, Chatterjee P, Church GMeLifeDirected differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression. Elife. 2023 02 21; 12.Elife2023-02-21T00:00:002023Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression.Authorship 1747903Authorship 15343021236947114Pierson Smela MD, Kramme CC, Fortuna PRJ, Adams JL, Su AR, Dong E, Kobayashi M, Brixi G, Kavirayuni VS, Tysinger E, Kohman RE, Shioda T, Chatterjee P, Church GMeLifeCorrection: Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression. Elife. 2023 Mar 22; 12.Elife2023-03-22T00:00:002023Correction: Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression.37020749Raju Paul S, Valiev I, Korek SE, Zyrin V, Shamsutdinova D, Gancharova O, Zaitsev A, Nuzhdina E, Davies DL, Dagogo-Jack I, Frenkel F, Brown JH, Hess JM, Viet S, Petersen JL, Wright CD, Ott HC, Auchincloss HG, Muniappan A, Shioda T, Lanuti M, Davis CM, Ehli EA, Hung YP, Mino-Kenudson M, Tsiper M, Sluder AE, Reeves PM, Kotlov N, Bagaev A, Ataullakhanov R, Poznansky MCFASEB bioAdvancesB cell-dependent subtypes and treatment-based immune correlates to survival in stage 3 and 4 lung adenocarcinomas. FASEB Bioadv. 2023 Apr; 5(4):156-170.FASEB Bioadv2023-02-16T00:00:002023B cell-dependent subtypes and treatment-based immune correlates to survival in stage 3 and 4 lung adenocarcinomas.Authorship 155923720Authorship 15571552Authorship 1572089237248279Lim J, Shioda T, Malott KF, Shioda K, Odajima J, Leon Parada KN, Nguyen J, Getze S, Lee M, Nguyen J, Reshel Blakeley S, Trinh V, Truong HA, Luderer UScientific reportsPrenatal exposure to benzo[a]pyrene depletes ovarian reserve and masculinizes embryonic ovarian germ cell transcriptome transgenerationally. Sci Rep. 2023 05 29; 13(1):8671.Sci Rep2023-05-29T00:00:002023Prenatal exposure to benzo[a]pyrene depletes ovarian reserve and masculinizes embryonic ovarian germ cell transcriptome transgenerationally.37464247Gell JJ, Shioda TMethods in molecular biology (Clifton, N.J.)Maintenance of Human Primordial Germ Cell-Like Cells in a Long-Term Culture System. Methods Mol Biol. 2023; 2677:259-267.Methods Mol Biol2023-01-01T00:00:002023Maintenance of Human Primordial Germ Cell-Like Cells in a Long-Term Culture System.Authorship 2884381Authorship 3555784Authorship 3752411true1George Jacob and Jacqueline Hazel Leder Professor of GeneticsGeorge Jacob and Jacqueline Hazel Leder Professor of Geneticstrue1Professor of MedicineProfessor of MedicineAuthorship 1609305438052962Lee H, Blumberg B, Lawrence MS, Shioda TNature geneticsRevisiting the use of structural similarity index in Hi-C. Nat Genet. 2023 Dec; 55(12):2049-2052.Nat Genet2023-12-05T00:00:002023Revisiting the use of structural similarity index in Hi-C.Authorship 161505412Authorship 1615838138077066Blumberg B, Cheng-An Chang R, Egusquiza R, Amato A, Li Z, Joloya E, Wheeler H, Nguyen A, Shioda K, Odajima J, Lawrence M, Shioda TResearch squareHeritable changes in chromatin contacts linked to transgenerational obesity. Res Sq. 2023 Nov 28.Res Sq2023-11-28T00:00:002023Heritable changes in chromatin contacts linked to transgenerational obesity.38099920Shioda T, Weiss RS, Bagrodia A, Frazier ALEnvironmental health perspectivesComment on "Comment on 'A Nested Case-Control Study of Serum Per- and Polyfluoroalkyl Substances and Testicular Germ Cell Tumors among U.S. Air Force Servicemen'". Environ Health Perspect. 2023 Dec; 131(12):128001.Environ Health Perspect2023-12-15T00:00:002023Comment on "Comment on 'A Nested Case-Control Study of Serum Per- and Polyfluoroalkyl Substances and Testicular Germ Cell Tumors among U.S. Air Force Servicemen'".Harvard T.H. Chan School of Public Health2025-07-31SHIODA, TOSHIHIRO2023-08-03Roles of the LTR5_Hs human-specific endogenous retroviruses in primordial germ cellsR21HD110839Principal Investigatortrue1Professor of GeneticsProfessor of Geneticstrue1Professor of PediatricsProfessor of Pediatricstrue1Caroline Shields Walker Professor of MedicineCaroline Shields Walker Professor of Medicinetrue1David G. Nathan Distinguished Professor of PediatricsDavid G. Nathan Distinguished Professor of Pediatricstrue1Dean of the FacultyDean of the FacultyAuthorship 3855206Authorship 4323509Authorship 4466323Authorship 4536787Authorship 3018424Authorship 3194415Authorship 33234211Authorship 6534618Authorship 6475519Authorship 6614746Authorship 660892623411111Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR, Lee DH, Myers JP, Shioda T, Soto AM, vom Saal FS, Welshons WV, Zoeller RTReproductive toxicology (Elmsford, N.Y.)Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology. Reprod Toxicol. 2013 Jul; 38:1-15.Reprod Toxicol2013-02-11T00:00:002013Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology.23593342Yeh WL, Shioda K, Coser KR, Rivizzigno D, McSweeney KR, Shioda TPloS oneFulvestrant-induced cell death and proteasomal degradation of estrogen receptor a protein in MCF-7 cells require the CSK c-Src tyrosine kinase. PLoS One. 2013; 8(4):e60889.PLoS One2013-04-04T00:00:002013Fulvestrant-induced cell death and proteasomal degradation of estrogen receptor a protein in MCF-7 cells require the CSK c-Src tyrosine kinase.23704952Wadia PR, Cabaton NJ, Borrero MD, Rubin BS, Sonnenschein C, Shioda T, Soto AMPloS oneLow-dose BPA exposure alters the mesenchymal and epithelial transcriptomes of the mouse fetal mammary gland. PLoS One. 2013; 8(5):e63902.PLoS One2013-05-21T00:00:002013Low-dose BPA exposure alters the mesenchymal and epithelial transcriptomes of the mouse fetal mammary gland.23595883Lee JM, Galkina EI, Levantovsky RM, Fossale E, Anne Anderson M, Gillis T, Srinidhi Mysore J, Coser KR, Shioda T, Zhang B, Furia MD, Derry J, Kohane IS, Seong IS, Wheeler VC, Gusella JF, MacDonald MEHuman molecular geneticsDominant effects of the Huntington's disease HTT CAG repeat length are captured in gene-expression data sets by a continuous analysis mathematical modeling strategy. Hum Mol Genet. 2013 Aug 15; 22(16):3227-38.Hum Mol Genet2013-04-16T00:00:002013Dominant effects of the Huntington's disease HTT CAG repeat length are captured in gene-expression data sets by a continuous analysis mathematical modeling strategy.Authorship 2170955Authorship 680354124062438Shioda T, Rosenthal NF, Coser KR, Suto M, Phatak M, Medvedovic M, Carey VJ, Isselbacher KJProceedings of the National Academy of Sciences of the United States of AmericaExpressomal approach for comprehensive analysis and visualization of ligand sensitivities of xenoestrogen responsive genes. Proc Natl Acad Sci U S A. 2013 Oct 08; 110(41):16508-13.Proc Natl Acad Sci U S A2013-09-23T00:00:002013Expressomal approach for comprehensive analysis and visualization of ligand sensitivities of xenoestrogen responsive genes.Authorship 696035824298054Liu M, Roth A, Yu M, Morris R, Bersani F, Rivera MN, Lu J, Shioda T, Vasudevan S, Ramaswamy S, Maheswaran S, Diederichs S, Haber DAGenes & developmentThe IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. Genes Dev. 2013 Dec 01; 27(23):2543-8.Genes Dev2013-12-01T00:00:002013The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis.Authorship 2629221Authorship 24898911Authorship 4550564Authorship 304971Authorship 4657151Authorship 311633Authorship 708379110665413Shioda T, Wakabayashi MChemosphereEffect of certain chemicals on the reproduction of medaka (Oryzias latipes). Chemosphere. 2000 Feb; 40(3):239-43.Chemosphere2000-02-01T00:00:002000Effect of certain chemicals on the reproduction of medaka (Oryzias latipes).Authorship 2438607Authorship 727004424751919Galkina EI, Shin A, Coser KR, Shioda T, Kohane IS, Seong IS, Wheeler VC, Gusella JF, Macdonald ME, Lee JMPloS oneHD CAGnome: a search tool for huntingtin CAG repeat length-correlated genes. PLoS One. 2014; 9(4):e95556.PLoS One2014-04-21T00:00:002014HD CAGnome: a search tool for huntingtin CAG repeat length-correlated genes.Authorship 739505724988533Dhimolea E, Wadia PR, Murray TJ, Settles ML, Treitman JD, Sonnenschein C, Shioda T, Soto AMPloS onePrenatal exposure to BPA alters the epigenome of the rat mammary gland and increases the propensity to neoplastic development. PLoS One. 2014; 9(7):e99800.PLoS One2014-07-02T00:00:002014Prenatal exposure to BPA alters the epigenome of the rat mammary gland and increases the propensity to neoplastic development.25013076Yu M, Bardia A, Aceto N, Bersani F, Madden MW, Donaldson MC, Desai R, Zhu H, Comaills V, Zheng Z, Wittner BS, Stojanov P, Brachtel E, Sgroi D, Kapur R, Shioda T, Ting DT, Ramaswamy S, Getz G, Iafrate AJ, Benes C, Toner M, Maheswaran S, Haber DAScience (New York, N.Y.)Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility. Science. 2014 Jul 11; 345(6193):216-20.Science2014-07-11T00:00:002014Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility.Authorship 74245116Authorship 7444082Authorship 7417703Authorship 74334816307881Shibuta H, Nozawa A, Shioda T, Kanda TInfection and immunityNeuraminidase activity and syncytial formation in variants of parainfluenza 3 virus. Infect Immun. 1983 Aug; 41(2):780-8.Infect Immun1983-08-01T00:00:001983Neuraminidase activity and syncytial formation in variants of parainfluenza 3 virus.1986308Shioda T, Levy JA, Cheng-Mayer CNatureMacrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 gene. Nature. 1991 Jan 10; 349(6305):167-9.Nature1991-01-10T00:00:001991Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 gene.11222678Sakuragi J, Shioda T, Panganiban ATJournal of virologyDuplication of the primary encapsidation and dimer linkage region of human immunodeficiency virus type 1 RNA results in the appearance of monomeric RNA in virions. J Virol. 2001 Mar; 75(6):2557-65.J Virol2001-03-01T00:00:002001Duplication of the primary encapsidation and dimer linkage region of human immunodeficiency virus type 1 RNA results in the appearance of monomeric RNA in virions.Authorship 3305237Authorship 3339879Authorship 500974Authorship 7544191425171411Aceto N, Bardia A, Miyamoto DT, Donaldson MC, Wittner BS, Spencer JA, Yu M, Pely A, Engstrom A, Zhu H, Brannigan BW, Kapur R, Stott SL, Shioda T, Ramaswamy S, Ting DT, Lin CP, Toner M, Haber DA, Maheswaran SCellCirculating tumor cell clusters are oligoclonal precursors of breast cancer metastasis. Cell. 2014 Aug 28; 158(5):1110-1122.Cell2014-08-28T00:00:002014Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis.25242334Ting DT, Wittner BS, Ligorio M, Vincent Jordan N, Shah AM, Miyamoto DT, Aceto N, Bersani F, Brannigan BW, Xega K, Ciciliano JC, Zhu H, MacKenzie OC, Trautwein J, Arora KS, Shahid M, Ellis HL, Qu N, Bardeesy N, Rivera MN, Deshpande V, Ferrone CR, Kapur R, Ramaswamy S, Shioda T, Toner M, Maheswaran S, Haber DACell reportsSingle-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells. Cell Rep. 2014 Sep 25; 8(6):1905-1918.Cell Rep2014-09-18T00:00:002014Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells.Authorship 75981125Authorship 4866987Authorship 4998969Authorship 772532725304370Friel AM, Zhang L, Pru CA, Clark NC, McCallum ML, Blok LJ, Shioda T, Peluso JJ, Rueda BR, Pru JKCancer lettersProgesterone receptor membrane component 1 deficiency attenuates growth while promoting chemosensitivity of human endometrial xenograft tumors. Cancer Lett. 2015 Jan 28; 356(2 Pt B):434-42.Cancer Lett2014-10-07T00:00:002014Progesterone receptor membrane component 1 deficiency attenuates growth while promoting chemosensitivity of human endometrial xenograft tumors.Authorship 4810465Authorship 77803848543575Takagi T, Muroya K, Iwama M, Shioda T, Tsukamoto T, Mizumoto KJournal of biochemistryIn vitro mRNA synthesis by Sendai virus: isolation and characterization of the transcription initiation complex. J Biochem. 1995 Aug; 118(2):390-6.J Biochem1995-08-01T00:00:001995In vitro mRNA synthesis by Sendai virus: isolation and characterization of the transcription initiation complex.Authorship 727308Authorship 3234061425758528Niederst MJ, Sequist LV, Poirier JT, Mermel CH, Lockerman EL, Garcia AR, Katayama R, Costa C, Ross KN, Moran T, Howe E, Fulton LE, Mulvey HE, Bernardo LA, Mohamoud F, Miyoshi N, VanderLaan PA, Costa DB, Jänne PA, Borger DR, Ramaswamy S, Shioda T, Iafrate AJ, Getz G, Rudin CM, Mino-Kenudson M, Engelman JANature communicationsRB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer. Nat Commun. 2015 Mar 11; 6:6377.Nat Commun2015-03-11T00:00:002015RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer.Authorship 5067005Authorship 465154Authorship 527421Authorship 5691124Authorship 55627310Authorship 2328596Authorship 2568944Authorship 18902114Authorship 312781225984697Sarioglu AF, Aceto N, Kojic N, Donaldson MC, Zeinali M, Hamza B, Engstrom A, Zhu H, Sundaresan TK, Miyamoto DT, Luo X, Bardia A, Wittner BS, Ramaswamy S, Shioda T, Ting DT, Stott SL, Kapur R, Maheswaran S, Haber DA, Toner MNature methodsA microfluidic device for label-free, physical capture of circulating tumor cell clusters. Nat Methods. 2015 Jul; 12(7):685-91.Nat Methods2015-05-18T00:00:002015A microfluidic device for label-free, physical capture of circulating tumor cell clusters.Authorship 5154161Authorship 4176232Authorship 3622216Authorship 3690795Authorship 4383602Authorship 4061817Authorship 3695995Authorship 4002665Authorship 4417928Authorship 7870482Authorship 79762422Authorship 8034371625678598Javaid S, Zhang J, Smolen GA, Yu M, Wittner BS, Singh A, Arora KS, Madden MW, Desai R, Zubrowski MJ, Schott BJ, Ting DT, Stott SL, Toner M, Maheswaran S, Shioda T, Ramaswamy S, Haber DAMolecular cancer research : MCRMAPK7 Regulates EMT Features and Modulates the Generation of CTCs. Mol Cancer Res. 2015 May; 13(5):934-43.Mol Cancer Res2015-02-12T00:00:002015MAPK7 Regulates EMT Features and Modulates the Generation of CTCs.25218215Janesick AS, Shioda T, Blumberg BMolecular and cellular endocrinologyTransgenerational inheritance of prenatal obesogen exposure. Mol Cell Endocrinol. 2014 Dec; 398(1-2):31-5.Mol Cell Endocrinol2014-09-16T00:00:002014Transgenerational inheritance of prenatal obesogen exposure.Authorship 344006Authorship 4150194Authorship 48967911Authorship 3782016Authorship 80951315Authorship 3498981Authorship 3771981Authorship 4320761Authorship 8339611826383955Miyamoto DT, Zheng Y, Wittner BS, Lee RJ, Zhu H, Broderick KT, Desai R, Fox DB, Brannigan BW, Trautwein J, Arora KS, Desai N, Dahl DM, Sequist LV, Smith MR, Kapur R, Wu CL, Shioda T, Ramaswamy S, Ting DT, Toner M, Maheswaran S, Haber DAScience (New York, N.Y.)RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance. Science. 2015 Sep 18; 349(6254):1351-6.Science2015-09-18T00:00:002015RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance.Authorship 8374031326394836Tajima K, Yae T, Javaid S, Tam O, Comaills V, Morris R, Wittner BS, Liu M, Engstrom A, Takahashi F, Black JC, Ramaswamy S, Shioda T, Hammell M, Haber DA, Whetstine JR, Maheswaran SNature communicationsSETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes. Nat Commun. 2015 Sep 23; 6:8257.Nat Commun2015-09-23T00:00:002015SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes.Authorship 37759510Authorship 843136926479444Miyoshi N, Wittner BS, Shioda K, Hitora T, Ito T, Ramaswamy S, Isselbacher KJ, Sgroi DC, Shioda TOncogenesisNodes-and-connections RNAi knockdown screening: identification of a signaling molecule network involved in fulvestrant action and breast cancer prognosis. Oncogenesis. 2015 Oct 19; 4:e172.Oncogenesis2015-10-19T00:00:002015Nodes-and-connections RNAi knockdown screening: identification of a signaling molecule network involved in fulvestrant action and breast cancer prognosis.Authorship 46967510Authorship 4855142Authorship 872768526785864Clark NC, Friel AM, Pru CA, Zhang L, Shioda T, Rueda BR, Peluso JJ, Pru JKCancer biology & therapyProgesterone receptor membrane component 1 promotes survival of human breast cancer cells and the growth of xenograft tumors. Cancer Biol Ther. 2016; 17(3):262-71.Cancer Biol Ther2016-01-19T00:00:002016Progesterone receptor membrane component 1 promotes survival of human breast cancer cells and the growth of xenograft tumors.Authorship 3726221Authorship 8939571Associate Professor0Full Professor4Instructor5Other FacultyAuthorship 968892Authorship 5732612Authorship 99566427524439Silberstein L, Goncalves KA, Kharchenko PV, Turcotte R, Kfoury Y, Mercier F, Baryawno N, Severe N, Bachand J, Spencer JA, Papazian A, Lee D, Chitteti BR, Srour EF, Hoggatt J, Tate T, Lo Celso C, Ono N, Nutt S, Heino J, Sipilä K, Shioda T, Osawa M, Lin CP, Hu GF, Scadden DTCell stem cellProximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators. 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