Boulton AJ, Vinik AI, Arezzo JC, Bril V, Feldman EL, Freeman R, Malik RA, Maser RE, Sosenko JM, Ziegler D
Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care. 2005 Apr; 28(4):956-62.
Diabetic neuropathies: a statement by the American Diabetes Association.
Zarich S, Waxman S, Freeman RT, Mittleman M, Hegarty P, Nesto RW
Journal of the American College of Cardiology
Effect of autonomic nervous system dysfunction on the circadian pattern of myocardial ischemia in diabetes mellitus. J Am Coll Cardiol. 1994 Oct; 24(4):956-62.
Effect of autonomic nervous system dysfunction on the circadian pattern of myocardial ischemia in diabetes mellitus.
Pure autonomic failure: an immaculate misconception? Neurology. 2004 Sep 28; 63(6):953-4.
Pure autonomic failure: an immaculate misconception?
Wieling W, Colman N, Krediet CT, Freeman R
Clinical autonomic research : official journal of the Clinical Autonomic Research Society
Nonpharmacological treatment of reflex syncope. Clin Auton Res. 2004 Oct; 14 Suppl 1:62-70.
Nonpharmacological treatment of reflex syncope.
Autonomic peripheral neuropathy. Lancet. 2005 Apr 2-8; 365(9466):1259-70.
Clinical practice. Neurogenic orthostatic hypotension. N Engl J Med. 2008 Feb 07; 358(6):615-24.
Clinical practice. Neurogenic orthostatic hypotension.
Autonomic neuroscience : basic & clinical
Highlights in clinical autonomic neuroscience: latest discoveries from the octopus pot. Auton Neurosci. 2012 Jul 02; 169(1):4-6.
Highlights in clinical autonomic neuroscience: latest discoveries from the octopus pot.
Kaufmann H, Saadia D, Voustianiouk A, Goldstein DS, Holmes C, Yahr MD, Nardin R, Freeman R
Norepinephrine precursor therapy in neurogenic orthostatic hypotension. Circulation. 2003 Aug 12; 108(6):724-8.
Norepinephrine precursor therapy in neurogenic orthostatic hypotension.
Journal of neurology, neurosurgery, and psychiatry
Autonomic neuropathy and coeliac disease. J Neurol Neurosurg Psychiatry. 2005 Apr; 76(4):579-81.
Autonomic neuropathy and coeliac disease.
Assessment of cardiovascular autonomic function. Suppl Clin Neurophysiol. 2004; 57:369-75.
Assessment of cardiovascular autonomic function.
Determining heart-rate variability: comparing methodologies using computer simulations. Muscle Nerve. 1993 Mar; 16(3):267-77.
Determining heart-rate variability: comparing methodologies using computer simulations.
Capsaicin induces degeneration of cutaneous autonomic nerve fibers. Ann Neurol. 2010 Dec; 68(6):888-98.
Capsaicin induces degeneration of cutaneous autonomic nerve fibers.
Gibbons CH, Illigens BM, Centi J, Freeman R
QDIRT: quantitative direct and indirect test of sudomotor function. Neurology. 2008 Jun 10; 70(24):2299-304.
QDIRT: quantitative direct and indirect test of sudomotor function.
Gewandter JS, Brell J, Cavaletti G, Dougherty PM, Evans S, Howie L, McDermott MP, O'Mara A, Smith AG, Dastros-Pitei D, Gauthier LR, Haroutounian S, Jarpe M, Katz NP, Loprinzi C, Richardson P, Lavoie-Smith EM, Wen PY, Turk DC, Dworkin RH, Freeman R
Trial designs for chemotherapy-induced peripheral neuropathy prevention: ACTTION recommendations. Neurology. 2018 08 28; 91(9):403-413.
Trial designs for chemotherapy-induced peripheral neuropathy prevention: ACTTION recommendations.
Simpson DM, Schifitto G, Clifford DB, Murphy TK, Durso-De Cruz E, Glue P, Whalen E, Emir B, Scott GN, Freeman R
Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trial. Neurology. 2010 Feb 02; 74(5):413-20.
Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trial.
Treatment-induced diabetic neuropathy: a reversible painful autonomic neuropathy. Ann Neurol. 2010 Apr; 67(4):534-41.
Treatment-induced diabetic neuropathy: a reversible painful autonomic neuropathy.
Freeman R, Abuzinadah AR, Gibbons C, Jones P, Miglis MG, Sinn DI
Orthostatic Hypotension: JACC State-of-the-Art Review. J Am Coll Cardiol. 2018 09 11; 72(11):1294-1309.
Orthostatic Hypotension: JACC State-of-the-Art Review.
Tesfaye S, Boulton AJ, Dyck PJ, Freeman R, Horowitz M, Kempler P, Lauria G, Malik RA, Spallone V, Vinik A, Bernardi L, Valensi P
Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care. 2010 Oct; 33(10):2285-93.
Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments.
Transfer function analysis of respiratory sinus arrhythmia: a measure of autonomic function in diabetic neuropathy. Muscle Nerve. 1995 Jan; 18(1):74-84.
Transfer function analysis of respiratory sinus arrhythmia: a measure of autonomic function in diabetic neuropathy.
Freeman R, Saul JP, Roberts MS, Berger RD, Broadbridge C, Cohen RJ
Spectral analysis of heart rate in diabetic autonomic neuropathy. A comparison with standard tests of autonomic function. Arch Neurol. 1991 Feb; 48(2):185-90.
Spectral analysis of heart rate in diabetic autonomic neuropathy. A comparison with standard tests of autonomic function.
Is time of the essence? The continuing search for a noninvasive measure of sympathetic adrenergic function. Neurology. 2005 Nov 22; 65(10):1517.
Is time of the essence? The continuing search for a noninvasive measure of sympathetic adrenergic function.
Ahn AC, Bennani T, Freeman R, Hamdy O, Kaptchuk TJ
Acupuncture in medicine : journal of the British Medical Acupuncture Society
Two styles of acupuncture for treating painful diabetic neuropathy--a pilot randomised control trial. Acupunct Med. 2007 Jun; 25(1-2):11-7.
Two styles of acupuncture for treating painful diabetic neuropathy--a pilot randomised control trial.
Adler GK, Bonyhay I, Failing H, Waring E, Dotson S, Freeman R
Antecedent hypoglycemia impairs autonomic cardiovascular function: implications for rigorous glycemic control. Diabetes. 2009 Feb; 58(2):360-6.
Antecedent hypoglycemia impairs autonomic cardiovascular function: implications for rigorous glycemic control.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Novel immunohistochemical techniques using discrete signal amplification systems for human cutaneous peripheral nerve fiber imaging. J Histochem Cytochem. 2011 Apr; 59(4):382-90.
Novel immunohistochemical techniques using discrete signal amplification systems for human cutaneous peripheral nerve fiber imaging.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
The treatment of autonomic dysfunction. J Clin Neurophysiol. 1993 Jan; 10(1):61-82.
Freeman R, Weiss ST, Roberts M, Zbikowski SM, Sparrow D
The relationship between heart rate variability and measures of body habitus. Clin Auton Res. 1995 Oct; 5(5):261-6.
The relationship between heart rate variability and measures of body habitus.
Newer agents for the treatment of painful diabetic peripheral neuropathy. Curr Diab Rep. 2005 Dec; 5(6):409-16.
Newer agents for the treatment of painful diabetic peripheral neuropathy.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Assessment of cardiovascular autonomic function. Clin Neurophysiol. 2006 Apr; 117(4):716-30.
Freeman R, Edwards R, Baron R, Bruehl S, Cruccu G, Dworkin RH, Haroutounian S
AAPT Diagnostic Criteria for Peripheral Neuropathic Pain: Focal and Segmental Disorders. J Pain. 2019 04; 20(4):369-393.
AAPT Diagnostic Criteria for Peripheral Neuropathic Pain: Focal and Segmental Disorders.
Lipsitz LA, Ryan SM, Parker JA, Freeman R, Wei JY, Goldberger AL
Hemodynamic and autonomic nervous system responses to mixed meal ingestion in healthy young and old subjects and dysautonomic patients with postprandial hypotension. Circulation. 1993 Feb; 87(2):391-400.
Hemodynamic and autonomic nervous system responses to mixed meal ingestion in healthy young and old subjects and dysautonomic patients with postprandial hypotension.
Human studies of recombinant human nerve growth factor and diabetic peripheral neuropathy. Eur Neurol. 1999; 41 Suppl 1:20-6.
Human studies of recombinant human nerve growth factor and diabetic peripheral neuropathy.
Quantitative sensory testing cannot differentiate simulated sensory loss from sensory neuropathy. Neurology. 2003 Feb 11; 60(3):465-70.
Quantitative sensory testing cannot differentiate simulated sensory loss from sensory neuropathy.
Freeman R, Raskin P, Hewitt DJ, Vorsanger GJ, Jordan DM, Xiang J, Rosenthal NR
Randomized study of tramadol/acetaminophen versus placebo in painful diabetic peripheral neuropathy. Curr Med Res Opin. 2007 Jan; 23(1):147-61.
Randomized study of tramadol/acetaminophen versus placebo in painful diabetic peripheral neuropathy.
Autonomic peripheral neuropathy. Neurol Clin. 2007 Feb; 25(1):277-301.
Thomas S, Ajroud-Driss S, Dimachkie MM, Gibbons C, Freeman R, Simpson DM, Singleton JR, Smith AG, Höke A
Journal of the peripheral nervous system : JPNS
Peripheral Neuropathy Research Registry: A prospective cohort. J Peripher Nerv Syst. 2019 03; 24(1):39-47.
Peripheral Neuropathy Research Registry: A prospective cohort.
Not all neuropathy in diabetes is of diabetic etiology: differential diagnosis of diabetic neuropathy. Curr Diab Rep. 2009 Dec; 9(6):423-31.
Not all neuropathy in diabetes is of diabetic etiology: differential diagnosis of diabetic neuropathy.
Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schatz IJ, Schondorf R, Stewart JM, van Dijk JG
Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Auton Neurosci. 2011 Apr 26; 161(1-2):46-8.
Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome.
Stankovic I, Quinn N, Vignatelli L, Antonini A, Berg D, Coon E, Cortelli P, Fanciulli A, Ferreira JJ, Freeman R, Halliday G, Höglinger GU, Iodice V, Kaufmann H, Klockgether T, Kostic V, Krismer F, Lang A, Levin J, Low P, Mathias C, Meissner WG, Kaufmann LN, Palma JA, Panicker JN, Pellecchia MT, Sakakibara R, Schmahmann J, Scholz SW, Singer W, Stamelou M, Tolosa E, Tsuji S, Seppi K, Poewe W, Wenning GK
Movement disorders : official journal of the Movement Disorder Society
A critique of the second consensus criteria for multiple system atrophy. Mov Disord. 2019 07; 34(7):975-984.
A critique of the second consensus criteria for multiple system atrophy.
Miriam H. Stoneman Professor of Radiology
The Functional Neuroanatomy of the Human Physiological Stress Response
Rongxiang Xu, MD Professor of Surgery in the Field of Regenerative Therapeutics
Assistant Professor of Emergency Medicine
Gewandter JS, Gibbons CH, Campagnolo M, Lee J, Chaudari J, Ward N, Burke L, Cavaletti G, Herrmann DN, McArthur JC, Russell JW, Smith AG, Smith SM, Turk DC, Dworkin RH, Freeman R
Clinician-rated measures for distal symmetrical axonal polyneuropathy: ACTTION systematic review. Neurology. 2019 08 20; 93(8):346-360.
Clinician-rated measures for distal symmetrical axonal polyneuropathy: ACTTION systematic review.
González-Duarte A, Cárdenas-Soto K, Fueyo O, Bañuelos CE, Gibbons C, Freeman R
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
Small fibre neuropathy assessments in early stages of hATTR amyloidosis. Amyloid. 2019; 26(sup1):55-56.
Small fibre neuropathy assessments in early stages of hATTR amyloidosis.
Barboi A, Gibbons CH, Axelrod F, Benarroch EE, Biaggioni I, Chapleau MW, Chelimsky G, Chelimsky T, Cheshire WP, Claydon VE, Freeman R, Goldstein DS, Joyner MJ, Kaufmann H, Low PA, Norcliffe-Kaufmann L, Robertson D, Shibao CA, Singer W, Snapper H, Vernino S, Raj SR
Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society. Clin Auton Res. 2020 02; 30(1):13-18.
Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society.
Isonaka R, Gibbons CH, Wang N, Freeman R, Goldstein DS
Association of innervation-adjusted alpha-synuclein in arrector pili muscles with cardiac noradrenergic deficiency in autonomic synucleinopathies. Clin Auton Res. 2019 12; 29(6):587-593.
Association of innervation-adjusted alpha-synuclein in arrector pili muscles with cardiac noradrenergic deficiency in autonomic synucleinopathies.
Barboi A, Gibbons CH, Bennaroch EE, Biaggioni I, Chapleau MW, Chelimsky G, Chelimsky T, Cheshire WP, Claydon VE, Freeman R, Goldstein DS, Joyner MJ, Kaufmann H, Low PA, Norcliffe-Kaufmann L, Robertson D, Shibao CA, Singer W, Snapper H, Vernino S, Raj SR
Response to: Human papillomavirus (HPV) vaccine safety concerning POTS, CRPS and related conditions. Clin Auton Res. 2020 04; 30(2):183-184.
Response to: Human papillomavirus (HPV) vaccine safety concerning POTS, CRPS and related conditions.
Gewandter JS, Dworkin RH, Turk DC, Devine EG, Hewitt D, Jensen MP, Katz NP, Kirkwood AA, Malamut R, Markman JD, Vrijens B, Burke L, Campbell JN, Carr DB, Conaghan PG, Cowan P, Doyle MK, Edwards RR, Evans SR, Farrar JT, Freeman R, Gilron I, Juge D, Kerns RD, Kopecky EA, McDermott MP, Niebler G, Patel KV, Rauck R, Rice ASC, Rowbotham M, Sessler NE, Simon LS, Singla N, Skljarevski V, Tockarshewsky T, Vanhove GF, Wasan AD, Witter J
Improving Study Conduct and Data Quality in Clinical Trials of Chronic Pain Treatments: IMMPACT Recommendations. J Pain. 2020 Sep - Oct; 21(9-10):931-942.
Improving Study Conduct and Data Quality in Clinical Trials of Chronic Pain Treatments: IMMPACT Recommendations.
Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society. Auton Neurosci. 2020 01; 223:102550.
Gibbons CH, Wang N, Kim JY, Campagnolo M, Freeman R
Skin Biopsy in Evaluation of Autonomic Disorders. Continuum (Minneap Minn). 2020 Feb; 26(1):200-212.
Skin Biopsy in Evaluation of Autonomic Disorders.
Latov N, Gorson KC, Brannagan TH, Freeman RL, Apostolski S, Berger AR, Bradley WG, Briani C, Bril V, Busis NA, Cros DP, Dalakas MC, Donofrio PD, Dyck PJ, England JD, Fisher MA, Herrmann DN, Menkes DL, Sahenk Z, Sander HW, Triggs WJ, Vallat JM
Journal of clinical neuromuscular disease
Diagnosis and Treatment of Chronic Immune-mediated Neuropathies. J Clin Neuromuscul Dis. 2006 Mar; 7(3):141-57.
Diagnosis and Treatment of Chronic Immune-mediated Neuropathies.
Freeman R, Illigens BMW, Lapusca R, Campagnolo M, Abuzinadah AR, Bonyhay I, Sinn DI, Miglis M, White J, Gibbons CH
Symptom Recognition Is Impaired in Patients With Orthostatic Hypotension. Hypertension. 2020 05; 75(5):1325-1332.
Symptom Recognition Is Impaired in Patients With Orthostatic Hypotension.
Sohn E, Suh BC, Wang N, Freeman R, Gibbons CH
A novel method to quantify cutaneous vascular innervation. Muscle Nerve. 2020 10; 62(4):492-501.
A novel method to quantify cutaneous vascular innervation.
Leung JH, Bayomy OF, Bonyhay I, Celli J, White J, Freeman R, Adler GK
The Journal of clinical endocrinology and metabolism
ACTH Infusion Impairs Baroreflex Sensitivity-Implications for Cardiovascular Hypoglycemia-Associated Autonomic Failure. J Clin Endocrinol Metab. 2020 07 01; 105(7).
ACTH Infusion Impairs Baroreflex Sensitivity-Implications for Cardiovascular Hypoglycemia-Associated Autonomic Failure.
Smith SM, Dworkin RH, Turk DC, McDermott MP, Eccleston C, Farrar JT, Rowbotham MC, Bhagwagar Z, Burke LB, Cowan P, Ellenberg SS, Evans SR, Freeman RL, Garrison LP, Iyengar S, Jadad A, Jensen MP, Junor R, Kamp C, Katz NP, Kesslak JP, Kopecky EA, Lissin D, Markman JD, Mease PJ, O'Connor AB, Patel KV, Raja SN, Sampaio C, Schoenfeld D, Singh J, Steigerwald I, Strand V, Tive LA, Tobias J, Wasan AD, Wilson HD
Interpretation of chronic pain clinical trial outcomes: IMMPACT recommended considerations. Pain. 2020 11; 161(11):2446-2461.
Interpretation of chronic pain clinical trial outcomes: IMMPACT recommended considerations.
Koulouris AE, Edwards RR, Dorado K, Schreiber KL, Lazaridou A, Rajan S, White J, Garcia J, Gibbons C, Freeman R
Reliability and Validity of the Boston Bedside Quantitative Sensory Testing Battery for Neuropathic Pain. Pain Med. 2020 10 01; 21(10):2336-2347.
Reliability and Validity of the Boston Bedside Quantitative Sensory Testing Battery for Neuropathic Pain.
Delayed orthostatic hypotension. Auton Neurosci. 2020 12; 229:102724.
Phosphorylated Alpha-Synuclein Within Cutaneous Autonomic Nerves of Patients With Parkinson's Disease: The Implications of Sample Thickness on Results. J Histochem Cytochem. 2020 10; 68(10):669-678.
Phosphorylated Alpha-Synuclein Within Cutaneous Autonomic Nerves of Patients With Parkinson's Disease: The Implications of Sample Thickness on Results.
Freeman R, Gewandter JS, Faber CG, Gibbons C, Haroutounian S, Lauria G, Levine T, Malik RA, Singleton JR, Smith AG, Bell J, Dworkin RH, Feldman E, Herrmann DN, Hoke A, Kolb N, Mansikka H, Oaklander AL, Peltier A, Polydefkis M, Ritt E, Russell JW, Sainati S, Steiner D, Treister R, Üçeyler N
Idiopathic distal sensory polyneuropathy: ACTTION diagnostic criteria. Neurology. 2020 12 01; 95(22):1005-1014.
Idiopathic distal sensory polyneuropathy: ACTTION diagnostic criteria.
Cheshire WP, Freeman R, Gibbons CH, Cortelli P, Wenning GK, Hilz MJ, Spies JM, Lipp A, Sandroni P, Wada N, Mano A, Ah Kim H, Kimpinski K, Iodice V, Idiáquez J, Thaisetthawatkul P, Coon EA, Low PA, Singer W
Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology. Clin Neurophysiol. 2021 02; 132(2):666-682.
Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology.
Cardiovascular exercise as a treatment of postural orthostatic tachycardia syndrome: A pragmatic treatment trial. Heart Rhythm. 2021 08; 18(8):1361-1368.
Cardiovascular exercise as a treatment of postural orthostatic tachycardia syndrome: A pragmatic treatment trial.
Haroutounian S, Todorovic MS, Leinders M, Campagnolo M, Gewandter JS, Dworkin RH, Freeman R
Diagnostic criteria for idiopathic small fiber neuropathy: A systematic review. Muscle Nerve. 2021 02; 63(2):170-177.
Diagnostic criteria for idiopathic small fiber neuropathy: A systematic review.
Terkelsen AJ, Karlsson P, Lauria G, Freeman R, Finnerup NB, Jensen TS
The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes. Lancet Neurol. 2017 11; 16(11):934-944.
The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes.
Enhanced Cholinergic Activity Improves Cerebral Blood Flow during Orthostatic Stress. Front Neurol. 2017; 8:103.
Enhanced Cholinergic Activity Improves Cerebral Blood Flow during Orthostatic Stress.
Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, Malik RA, Sosenko JM, Ziegler D
Diabetic Neuropathy: A Position Statement by the American Diabetes Association. Diabetes Care. 2017 01; 40(1):136-154.
Diabetic Neuropathy: A Position Statement by the American Diabetes Association.
Ziegler D, Low PA, Freeman R, Tritschler H, Vinik AI
Journal of diabetes and its complications
Predictors of improvement and progression of diabetic polyneuropathy following treatment with a-lipoic acid for 4 years in the NATHAN 1 trial. J Diabetes Complications. 2016 Mar; 30(2):350-6.
Predictors of improvement and progression of diabetic polyneuropathy following treatment with a-lipoic acid for 4 years in the NATHAN 1 trial.
Recent advances in familial amyloid polyneuropathy. Curr Opin Neurol. 2015 Oct; 28(5):494-9.
Recent advances in familial amyloid polyneuropathy.
Predictors of placebo response in peripheral neuropathic pain: insights from pregabalin clinical trials. J Pain Res. 2015; 8:257-68.
Predictors of placebo response in peripheral neuropathic pain: insights from pregabalin clinical trials.
Harden RN, Freeman R, Rainka M, Zhang L, Bell C, Berges A, Chen C, Graff O, Harding K, Hunter S, Kavanagh S, Schwartzbach C, Warren S, McClung C
A phase 2a, randomized, crossover trial of gabapentin enacarbil for the treatment of postherpetic neuralgia in gabapentin inadequate responders. Pain Med. 2013 Dec; 14(12):1918-32.
A phase 2a, randomized, crossover trial of gabapentin enacarbil for the treatment of postherpetic neuralgia in gabapentin inadequate responders.
Autonomic Peripheral Neuropathy. Continuum (Minneap Minn). 2020 Feb; 26(1):58-71.
Karlsson P, Hincker AM, Jensen TS, Freeman R, Haroutounian S
Structural, functional, and symptom relations in painful distal symmetric polyneuropathies: a systematic review. Pain. 2019 Feb; 160(2):286-297.
Structural, functional, and symptom relations in painful distal symmetric polyneuropathies: a systematic review.
Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D, Freeman R, Truini A, Attal N, Finnerup NB, Eccleston C, Kalso E, Bennett DL, Dworkin RH, Raja SN
Neuropathic pain. Nat Rev Dis Primers. 2017 Feb 16; 3:17002.
The puzzle of orthostatic tolerance in hereditary sensory and autonomic neuropathy, type IV. Ann Neurol. 2015 May; 77(5):741-2.
The puzzle of orthostatic tolerance in hereditary sensory and autonomic neuropathy, type IV.
Gewandter JS, Dworkin RH, Finnerup NB, Freeman R, Mohile NA
Laurens B, Constantinescu R, Freeman R, Gerhard A, Jellinger K, Jeromin A, Krismer F, Mollenhauer B, Schlossmacher MG, Shaw LM, Verbeek MM, Wenning GK, Winge K, Zhang J, Meissner WG
Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative. Neurobiol Dis. 2015 Aug; 80:29-41.
Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.
Biaggioni I, Freeman R, Mathias CJ, Low P, Hewitt LA, Kaufmann H
Randomized withdrawal study of patients with symptomatic neurogenic orthostatic hypotension responsive to droxidopa. Hypertension. 2015 Jan; 65(1):101-7.
Randomized withdrawal study of patients with symptomatic neurogenic orthostatic hypotension responsive to droxidopa.
Zhang L, Rainka M, Freeman R, Harden RN, Bell CF, Chen C, Graff O, Harding K, Hunter S, Kavanagh S, Laurijssens B, Schwartzbach C, Warren S, McClung C
A randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of gabapentin enacarbil in subjects with neuropathic pain associated with postherpetic neuralgia (PXN110748). J Pain. 2013 Jun; 14(6):590-603.
A randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of gabapentin enacarbil in subjects with neuropathic pain associated with postherpetic neuralgia (PXN110748).
Kaufmann H, Freeman R, Biaggioni I, Low P, Pedder S, Hewitt LA, Mauney J, Feirtag M, Mathias CJ
Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial. Neurology. 2014 Jul 22; 83(4):328-35.
Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial.
Spallone V, Ziegler D, Freeman R, Bernardi L, Frontoni S, Pop-Busui R, Stevens M, Kempler P, Hilsted J, Tesfaye S, Low P, Valensi P
Diabetes/metabolism research and reviews
Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management. Diabetes Metab Res Rev. 2011 Oct; 27(7):639-53.
Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management.
Bernardi L, Spallone V, Stevens M, Hilsted J, Frontoni S, Pop-Busui R, Ziegler D, Kempler P, Freeman R, Low P, Tesfaye S, Valensi P
Methods of investigation for cardiac autonomic dysfunction in human research studies. Diabetes Metab Res Rev. 2011 Oct; 27(7):654-64.
Methods of investigation for cardiac autonomic dysfunction in human research studies.
Wadhawan S, Pant S, Golhar R, Kirov S, Thompson J, Jacobsen L, Qureshi I, Ajroud-Driss S, Freeman R, Simpson DM, Smith AG, Hoke A, Bristow LJ
NaV channel variants in patients with painful and nonpainful peripheral neuropathy. Neurol Genet. 2017 Dec; 3(6):e207.
NaV channel variants in patients with painful and nonpainful peripheral neuropathy.
Gewandter JS, Freeman R, Kitt RA, Cavaletti G, Gauthier LR, McDermott MP, Mohile NA, Mohlie SG, Smith AG, Tejani MA, Turk DC, Dworkin RH
Chemotherapy-induced peripheral neuropathy clinical trials: Review and recommendations. Neurology. 2017 Aug 22; 89(8):859-869.
Chemotherapy-induced peripheral neuropathy clinical trials: Review and recommendations.
Lee JM, Derkinderen P, Kordower JH, Freeman R, Munoz DG, Kremer T, Zago W, Hutten SJ, Adler CH, Serrano GE, Beach TG
Journal of neuropathology and experimental neurology
The Search for a Peripheral Biopsy Indicator of a-Synuclein Pathology for Parkinson Disease. J Neuropathol Exp Neurol. 2017 01 01; 76(1):2-15.
The Search for a Peripheral Biopsy Indicator of a-Synuclein Pathology for Parkinson Disease.
Thakur S, Dworkin RH, Freeman R, Gorson KC, Herrmann DN
Pain in acquired inflammatory demyelinating polyneuropathies. Pain. 2016 09; 157(9):1887-1894.
Pain in acquired inflammatory demyelinating polyneuropathies.
van Hecke O, Kamerman PR, Attal N, Baron R, Bjornsdottir G, Bennett DLH, Bennett MI, Bouhassira D, Diatchenko L, Freeman R, Freynhagen R, Haanpää M, Jensen TS, Raja SN, Rice ASC, Seltzer Z, Thorgeirsson TE, Yarnitsky D, Smith BH
Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations. Pain. 2015 Nov; 156(11):2337-2353.
Neuropathic pain phenotyping by international consensus (NeuroPPIC) for genetic studies: a NeuPSIG systematic review, Delphi survey, and expert panel recommendations.
Fedorowski A, Hamrefors V, Sutton R, van Dijk JG, Freeman R, Lenders JW, Wieling W
Do we need to evaluate diastolic blood pressure in patients with suspected orthostatic hypotension? Clin Auton Res. 2017 Jun; 27(3):167-173.
Do we need to evaluate diastolic blood pressure in patients with suspected orthostatic hypotension?
Finnerup NB, Haroutounian S, Kamerman P, Baron R, Bennett DLH, Bouhassira D, Cruccu G, Freeman R, Hansson P, Nurmikko T, Raja SN, Rice ASC, Serra J, Smith BH, Treede RD, Jensen TS
Neuropathic pain: an updated grading system for research and clinical practice. Pain. 2016 08; 157(8):1599-1606.
Neuropathic pain: an updated grading system for research and clinical practice.
Low PA, Robertson D, Gilman S, Kaufmann H, Singer W, Biaggioni I, Freeman R, Perlman S, Hauser RA, Cheshire W, Lessig S, Vernino S, Mandrekar J, Dupont WD, Chelimsky T, Galpern WR
Efficacy and safety of rifampicin for multiple system atrophy: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2014 Mar; 13(3):268-75.
Efficacy and safety of rifampicin for multiple system atrophy: a randomised, double-blind, placebo-controlled trial.
Objective evidence of autonomic dysfunction and the role of stress in the Gulf War syndrome. JAMA Neurol. 2013 Feb; 70(2):158-9.
Objective evidence of autonomic dysfunction and the role of stress in the Gulf War syndrome.
Doshi TL, Dworkin RH, Polomano RC, Carr DB, Edwards RR, Finnerup NB, Freeman RL, Paice JA, Weisman SJ, Raja SN
AAAPT Diagnostic Criteria for Acute Neuropathic Pain. Pain Med. 2021 03 18; 22(3):616-636.
AAAPT Diagnostic Criteria for Acute Neuropathic Pain.
Cheshire WP, Freeman R, Gibbons CH, Cortelli P, Wenning GK, Hilz MJ, Spies JM, Lipp A, Sandroni P, Wada N, Mano T, Kim HA, Kimpinski K, Iodice V, Idiáquez J, Thaisetthawatkul P, Coon EA, Low PA, Singer W
Corrigendum to "Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology" [Clin. Neurophysiol. 132(2) (2021) 666-682]. Clin Neurophysiol. 2021 May; 132(5):1194.
Corrigendum to "Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology" [Clin. Neurophysiol. 132(2) (2021) 666-682].
Levine TD, Bellaire B, Gibbons C, Freeman R
Annals of clinical and translational neurology
Cutaneous alpha-synuclein deposition in postural tachycardia patients. Ann Clin Transl Neurol. 2021 04; 8(4):908-917.
Cutaneous alpha-synuclein deposition in postural tachycardia patients.
Gewandter JS, Smith SM, Dworkin RH, Turk DC, Gan TJ, Gilron I, Hertz S, Katz NP, Markman JD, Raja SN, Rowbotham MC, Stacey BR, Strain EC, Ward DS, Farrar JT, Kroenke K, Rathmell JP, Rauck R, Brown C, Cowan P, Edwards RR, Eisenach JC, Ferguson M, Freeman R, Gray R, Giblin K, Grol-Prokopczyk H, Haythornthwaite J, Jamison RN, Martel M, McNicol E, L Oshinsky M, Sandbrink F, Scholz J, Scranton R, Simon LS, Steiner D, Verburg K, Wasan AD, Wentworth K
Research approaches for evaluating opioid sparing in clinical trials of acute and chronic pain treatments: Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials recommendations. Pain. 2021 11 01; 162(11):2669-2681.
Research approaches for evaluating opioid sparing in clinical trials of acute and chronic pain treatments: Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials recommendations.
Gibbons C, Donadio V, Sommer C, Liguori R, Lauria Pinter G, Lombardi R, Doppler K, Freeman R
Reader Response: In Vivo Distribution of a-Synuclein in Multiple Tissues and Biofluids in Parkinson Disease. Neurology. 2021 05 18; 96(20):964-965.
Reader Response: In Vivo Distribution of a-Synuclein in Multiple Tissues and Biofluids in Parkinson Disease.
Vernino S, Bourne KM, Stiles LE, Grubb BP, Fedorowski A, Stewart JM, Arnold AC, Pace LA, Axelsson J, Boris JR, Moak JP, Goodman BP, Chémali KR, Chung TH, Goldstein DS, Diedrich A, Miglis MG, Cortez MM, Miller AJ, Freeman R, Biaggioni I, Rowe PC, Sheldon RS, Shibao CA, Systrom DM, Cook GA, Doherty TA, Abdallah HI, Darbari A, Raj SR
Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1. Auton Neurosci. 2021 11; 235:102828.
Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1.
Miglis MG, Zitser J, Schneider L, During E, Jaradeh S, Freeman R, Gibbons CH
Cutaneous a-synuclein is correlated with autonomic impairment in isolated rapid eye movement sleep behavior disorder. Sleep. 2021 12 10; 44(12).
Cutaneous a-synuclein is correlated with autonomic impairment in isolated rapid eye movement sleep behavior disorder.
Sohn EH, Gibbons CH, Freeman R, Lee AY, Jung MS, Kim S
Journal of clinical neurology (Seoul, Korea)
Validation of the Korean version of the Boston Autonomic Symptom Questionnaire. J Clin Neurol. 2021 Jul; 17(3):463-469.
Validation of the Korean version of the Boston Autonomic Symptom Questionnaire.
Thijs RD, Brignole M, Falup-Pecurariu C, Fanciulli A, Freeman R, Guaraldi P, Jordan J, Habek M, Hilz M, Traon AP, Stankovic I, Struhal W, Sutton R, Wenning G, Van Dijk JG
Recommendations for tilt table testing and other provocative cardiovascular autonomic tests in conditions that may cause transient loss of consciousness : Consensus statement of the European Federation of Autonomic Societies (EFAS) endorsed by the American Autonomic Society (AAS) and the European Academy of Neurology (EAN). Clin Auton Res. 2021 06; 31(3):369-384.
Recommendations for tilt table testing and other provocative cardiovascular autonomic tests in conditions that may cause transient loss of consciousness : Consensus statement of the European Federation of Autonomic Societies (EFAS) endorsed by the American Autonomic Society (AAS) and the European Academy of Neurology (EAN).
Thijs RD, Brignole M, Falup-Pecurariu C, Fanciulli A, Freeman R, Guaraldi P, Jordan J, Habek M, Hilz M, Pavy-LeTraon A, Stankovic I, Struhal W, Sutton R, Wenning G, van Dijk JG
Recommendations for tilt table testing and other provocative cardiovascular autonomic tests in conditions that may cause transient loss of consciousness : Consensus statement of the European Federation of Autonomic Societies (EFAS) endorsed by the American Autonomic Society (AAS) and the European Academy of Neurology (EAN). Auton Neurosci. 2021 07; 233:102792.
Rice ASC, Dworkin RH, Finnerup NB, Attal N, Anand P, Freeman R, Piaia A, Callegari F, Doerr C, Mondal S, Narayanan N, Ecochard L, Flossbach Y, Pandhi S
Efficacy and safety of EMA401 in peripheral neuropathic pain: results of 2 randomised, double-blind, phase 2 studies in patients with postherpetic neuralgia and painful diabetic neuropathy. Pain. 2021 10 01; 162(10):2578-2589.
Efficacy and safety of EMA401 in peripheral neuropathic pain: results of 2 randomised, double-blind, phase 2 studies in patients with postherpetic neuralgia and painful diabetic neuropathy.
Raj SR, Bourne KM, Stiles LE, Miglis MG, Cortez MM, Miller AJ, Freeman R, Biaggioni I, Rowe PC, Sheldon RS, Shibao CA, Diedrich A, Systrom DM, Cook GA, Doherty TA, Abdallah HI, Grubb BP, Fedorowski A, Stewart JM, Arnold AC, Pace LA, Axelsson J, Boris JR, Moak JP, Goodman BP, Chémali KR, Chung TH, Goldstein DS, Darbari A, Vernino S
Postural orthostatic tachycardia syndrome (POTS): Priorities for POTS care and research from a 2019 National Institutes of Health Expert Consensus Meeting - Part 2. Auton Neurosci. 2021 11; 235:102836.
Postural orthostatic tachycardia syndrome (POTS): Priorities for POTS care and research from a 2019 National Institutes of Health Expert Consensus Meeting - Part 2.
A treatment for neurally mediated syncope? (Don't) hold your breath. Ann Neurol. 2008 Mar; 63(3):265-7.
A treatment for neurally mediated syncope? (Don't) hold your breath.
Gibbons CH, Freeman R, Tecilazich F, Dinh T, Lyons TE, Gnardellis C, Veves A
The evolving natural history of neurophysiologic function in patients with well-controlled diabetes. J Peripher Nerv Syst. 2013 Jun; 18(2):153-61.
The evolving natural history of neurophysiologic function in patients with well-controlled diabetes.
González-Duarte A, Varma-Doyle A, Freeman R
Pure autonomic failure and the differential diagnosis of autonomic peripheral neuropathies. Curr Opin Neurol. 2021 10 01; 34(5):675-682.
Pure autonomic failure and the differential diagnosis of autonomic peripheral neuropathies.
Jain SM, Balamurugan R, Tandon M, Mozaffarian N, Gudi G, Salhi Y, Holland R, Freeman R, Baron R
Randomized, double-blind, placebo-controlled trial of ISC 17536, an oral inhibitor of transient receptor potential ankyrin 1, in patients with painful diabetic peripheral neuropathy: impact of preserved small nerve fiber function. Pain. 2022 06 01; 163(6):e738-e747.
Randomized, double-blind, placebo-controlled trial of ISC 17536, an oral inhibitor of transient receptor potential ankyrin 1, in patients with painful diabetic peripheral neuropathy: impact of preserved small nerve fiber function.
Ziegler D, Tesfaye S, Spallone V, Gurieva I, Al Kaabi J, Mankovsky B, Martinka E, Radulian G, Nguyen KT, Stirban AO, Tankova T, Varkonyi T, Freeman R, Kempler P, Boulton AJ
Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice: International expert consensus recommendations. Diabetes Res Clin Pract. 2022 Apr; 186:109063.
Screening, diagnosis and management of diabetic sensorimotor polyneuropathy in clinical practice: International expert consensus recommendations.
Evidente VGH, Evidente DH, Ortega SC, Levine TD, Freeman R, Gibbons CH
X-Linked Dystonia-Parkinsonism ("Lubag") May Present with Peripheral Synucleinopathy. Mov Disord. 2022 01; 37(1):130-136.
X-Linked Dystonia-Parkinsonism ("Lubag") May Present with Peripheral Synucleinopathy.
Man JJ, Lu Q, Moss ME, Carvajal B, Baur W, Garza AE, Freeman R, Anastasiou M, Ngwenyama N, Adler GK, Alcaide P, Jaffe IZ
Arteriosclerosis, thrombosis, and vascular biology
Myeloid Mineralocorticoid Receptor Transcriptionally Regulates P-Selectin Glycoprotein Ligand-1 and Promotes Monocyte Trafficking and Atherosclerosis. Arterioscler Thromb Vasc Biol. 2021 11; 41(11):2740-2755.
Myeloid Mineralocorticoid Receptor Transcriptionally Regulates P-Selectin Glycoprotein Ligand-1 and Promotes Monocyte Trafficking and Atherosclerosis.
van Twist DJL, Harms MPM, van Wijnen VK, Claydon VE, Freeman R, Cheshire WP, Wieling W
Diagnostic criteria for initial orthostatic hypotension: a narrative review. Clin Auton Res. 2021 12; 31(6):685-698.
Diagnostic criteria for initial orthostatic hypotension: a narrative review.
Zaheer S, Meyer K, Easly R, Bayomy O, Leung J, Koefoed AW, Heydarpour M, Freeman R, Adler GK
Effect of adrenocorticotropic hormone infusion on circulating sclerostin levels. Endocr Connect. 2021 Dec 14; 10(12):1607-1614.
Effect of adrenocorticotropic hormone infusion on circulating sclerostin levels.
Forstenpointner J, Elman I, Freeman R, Borsook D
The omnipresence of autonomic modulation in health and disease. Prog Neurobiol. 2022 03; 210:102218.
The omnipresence of autonomic modulation in health and disease.
Gibbons CH, Freeman R, Bellaire B, Adler CH, Moore D, Levine T
Synuclein-One study: skin biopsy detection of phosphorylated a-synuclein for diagnosis of synucleinopathies. Biomark Med. 2022 05; 16(7):499-509.
Synuclein-One study: skin biopsy detection of phosphorylated a-synuclein for diagnosis of synucleinopathies.
Stress, hypoglycemia, and the autonomic nervous system. Auton Neurosci. 2022 07; 240:102983.
Stress, hypoglycemia, and the autonomic nervous system.
Wenning GK, Stankovic I, Vignatelli L, Fanciulli A, Calandra-Buonaura G, Seppi K, Palma JA, Meissner WG, Krismer F, Berg D, Cortelli P, Freeman R, Halliday G, Höglinger G, Lang A, Ling H, Litvan I, Low P, Miki Y, Panicker J, Pellecchia MT, Quinn N, Sakakibara R, Stamelou M, Tolosa E, Tsuji S, Warner T, Poewe W, Kaufmann H
The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy. Mov Disord. 2022 06; 37(6):1131-1148.
The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy.
Forstenpointner J, Maallo AMS, Elman I, Holmes S, Freeman R, Baron R, Borsook D
The solitary nucleus connectivity to key autonomic regions in humans. Eur J Neurosci. 2022 07; 56(2):3938-3966.
The solitary nucleus connectivity to key autonomic regions in humans.
Ndayisaba A, Pitaro AT, Willett AS, Jones KA, de Gusmao CM, Olsen AL, Kim J, Rissanen E, Woods JK, Srinivasan SR, Nagy A, Nagy A, Mesidor M, Cicero S, Patel V, Oakley DH, Tuncali I, Taglieri-Noble K, Clark EC, Paulson J, Krolewski RC, Ho GP, Hung AY, Wills AM, Hayes MT, Macmore JP, Warren L, Bower PG, Langer CB, Kellerman LR, Humphreys CW, Glanz BI, Dielubanza EJ, Frosch MP, Freeman RL, Gibbons CH, Stefanova N, Chitnis T, Weiner HL, Scherzer CR, Scholz SW, Vuzman D, Cox LM, Wenning G, Schmahmann JD, Gupta AS, Novak P, Young GS, Feany MB, Singhal T, Khurana V
Clinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping. Cerebellum. 2024 Feb; 23(1):31-51.
Clinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping.
Edwards RR, Schreiber KL, Dworkin RH, Turk DC, Baron R, Freeman R, Jensen TS, Latremoliere A, Markman JD, Rice ASC, Rowbotham M, Staud R, Tate S, Woolf CJ, Andrews NA, Carr DB, Colloca L, Cosma-Roman D, Cowan P, Diatchenko L, Farrar J, Gewandter JS, Gilron I, Kerns RD, Marchand S, Niebler G, Patel KV, Simon LS, Tockarshewsky T, Vanhove GF, Vardeh D, Walco GA, Wasan AD, Wesselmann U
Optimizing and Accelerating the Development of Precision Pain Treatments for Chronic Pain: IMMPACT Review and Recommendations. J Pain. 2023 02; 24(2):204-225.
Optimizing and Accelerating the Development of Precision Pain Treatments for Chronic Pain: IMMPACT Review and Recommendations.
Freeman R, Gonzalez-Duarte A, Barroso F, Campagnolo M, Rajan S, Garcia J, Kim JY, Wang N, Orellana L, Gibbons C
Cutaneous amyloid is a biomarker in early ATTRv neuropathy and progresses across disease stages. Ann Clin Transl Neurol. 2022 09; 9(9):1370-1383.
Cutaneous amyloid is a biomarker in early ATTRv neuropathy and progresses across disease stages.
Kleykamp BA, Dworkin RH, Turk DC, Bhagwagar Z, Cowan P, Eccleston C, Ellenberg SS, Evans SR, Farrar JT, Freeman RL, Garrison LP, Gewandter JS, Goli V, Iyengar S, Jadad AR, Jensen MP, Junor R, Katz NP, Kesslak JP, Kopecky EA, Lissin D, Markman JD, McDermott MP, Mease PJ, O'Connor AB, Patel KV, Raja SN, Rowbotham MC, Sampaio C, Singh JA, Steigerwald I, Strand V, Tive LA, Tobias J, Wasan AD, Wilson HD
Benefit-risk assessment and reporting in clinical trials of chronic pain treatments: IMMPACT recommendations. Pain. 2022 06 01; 163(6):1006-1018.
Benefit-risk assessment and reporting in clinical trials of chronic pain treatments: IMMPACT recommendations.
Correction to: Clinical trial-ready patient cohorts for multiple system atrophy: coupling biospecimen and iPSC banking to longitudinal deep-phenotyping. Cerebellum. 2024 Feb; 23(1):52-53.
Correction to: Clinical trial-ready patient cohorts for multiple system atrophy: coupling biospecimen and iPSC banking to longitudinal deep-phenotyping.
Gibbons C, Wang N, Rajan S, Kern D, Palma JA, Kaufmann H, Freeman R
Cutaneous a-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease. Neurology. 2023 04 11; 100(15):e1529-e1539.
Cutaneous a-Synuclein Signatures in Patients With Multiple System Atrophy and Parkinson Disease.
Siepmann T, Arndt M, Sedghi A, Szatmári S, Horváth T, Takáts A, Bereczki D, Moskopp ML, Buchmann S, Skowronek C, Zago W, Woranush W, Lapusca R, Weidemann ML, Gibbons CH, Freeman R, Reichmann H, Puetz V, Barlinn K, Pintér A, Illigens BM
Two-Year observational study of autonomic skin function in patients with Parkinson's disease compared to healthy individuals. Eur J Neurol. 2023 05; 30(5):1281-1292.
Two-Year observational study of autonomic skin function in patients with Parkinson's disease compared to healthy individuals.
Hohenschurz-Schmidt DJ, Cherkin D, Rice ASC, Dworkin RH, Turk DC, McDermott MP, Bair MJ, DeBar LL, Edwards RR, Farrar JT, Kerns RD, Markman JD, Rowbotham MC, Sherman KJ, Wasan AD, Cowan P, Desjardins P, Ferguson M, Freeman R, Gewandter JS, Gilron I, Grol-Prokopczyk H, Hertz SH, Iyengar S, Kamp C, Karp BI, Kleykamp BA, Loeser JD, Mackey S, Malamut R, McNicol E, Patel KV, Sandbrink F, Schmader K, Simon L, Steiner DJ, Veasley C, Vollert J
Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement. Pain. 2023 07 01; 164(7):1457-1472.
Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement.
Gewandter JS, Edwards RR, Hill KP, Wasan AD, Hooker JE, Lape EC, Besharat S, Cowan P, Le Foll B, Ditre JW, Freeman R
Cannabinoid Therapy: Attitudes and Experiences of People With Chronic Pain. Clin J Pain. 2023 06 01; 39(6):249-258.
Cannabinoid Therapy: Attitudes and Experiences of People With Chronic Pain.
Faber CG, Attal N, Lauria G, Dworkin RH, Freeman R, Dawson KT, Finnigan H, Hajihosseini A, Naik H, Serenko M, Morris CJ, Kotecha M
Efficacy and safety of vixotrigine in idiopathic or diabetes-associated painful small fibre neuropathy (CONVEY): a phase 2 placebo-controlled enriched-enrolment randomised withdrawal study. EClinicalMedicine. 2023 May; 59:101971.
Efficacy and safety of vixotrigine in idiopathic or diabetes-associated painful small fibre neuropathy (CONVEY): a phase 2 placebo-controlled enriched-enrolment randomised withdrawal study.
Haas AV, Koefoed A, Easly RM, Celli J, Heydarpour M, Bonyhay I, Freeman R, Adler GK
Effect of hypoglycemia on baroreflex sensitivity in individuals with type 2 diabetes: implications for autonomic control of cardiovascular function in diabetes. Clin Auton Res. 2023 12; 33(6):727-735.
Effect of hypoglycemia on baroreflex sensitivity in individuals with type 2 diabetes: implications for autonomic control of cardiovascular function in diabetes.
Michelson D, Chin WW, Dworkin RH, Freeman R, Herrmann DN, Mazitschek R, Pop-Busui R, Shaibani A, Vornov J, Jones M, Jarpe M, Hader B, Viera T, Hylan M, Kachmar T, Jones S
A randomized, double-blind, placebo-controlled study of histone deacetylase type 6 inhibition for the treatment of painful diabetic peripheral neuropathy. Pain Rep. 2023 Dec; 8(6):e1114.
A randomized, double-blind, placebo-controlled study of histone deacetylase type 6 inhibition for the treatment of painful diabetic peripheral neuropathy.
From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects
Sensory Phenotyping to Enhance Neuropathic Pain Drug Development
Finucane C, van Wijnen VK, Fan CW, Soraghan C, Byrne L, Westerhof BE, Freeman R, Fedorowski A, Harms MPM, Wieling W, Kenny R
A practical guide to active stand testing and analysis using continuous beat-to-beat non-invasive blood pressure monitoring. Clin Auton Res. 2019 08; 29(4):427-441.
A practical guide to active stand testing and analysis using continuous beat-to-beat non-invasive blood pressure monitoring.
van Doormaal PTC, Thomas S, Ajroud-Driss S, Cole RN, DeVine LR, Dimachkie MM, Geisler S, Freeman R, Simpson DM, Singleton JR, Smith AG, Stino A, Höke A
Plasma proteomic analysis on neuropathic pain in idiopathic peripheral neuropathy patients. J Peripher Nerv Syst. 2024 03; 29(1):88-96.
Plasma proteomic analysis on neuropathic pain in idiopathic peripheral neuropathy patients.
Journal of the Peripheral Nervous System. Supplement: Designing innovative therapies for neuropathic pain: 2014 FPN International Research Symposium. Introduction. J Peripher Nerv Syst. 2014 Oct; 19 Suppl 2:S1.
Journal of the Peripheral Nervous System. Supplement: Designing innovative therapies for neuropathic pain: 2014 FPN International Research Symposium. Introduction.
Designing innovative therapies for neuropathic pain: preclinical and early clinical development challenges. J Peripher Nerv Syst. 2014 Oct; 19 Suppl 2:S28-9.
Designing innovative therapies for neuropathic pain: preclinical and early clinical development challenges.
Kempler P, Amarenco G, Freeman R, Frontoni S, Horowitz M, Stevens M, Low P, Pop-Busui R, Tahrani AA, Tesfaye S, Várkonyi T, Ziegler D, Valensi P
Management strategies for gastrointestinal, erectile, bladder, and sudomotor dysfunction in patients with diabetes. Diabetes Metab Res Rev. 2011 Oct; 27(7):665-77.
Management strategies for gastrointestinal, erectile, bladder, and sudomotor dysfunction in patients with diabetes.
Haroutounian S, Holzer KJ, Kerns RD, Veasley C, Dworkin RH, Turk DC, Carman KL, Chambers CT, Cowan P, Edwards RR, Eisenach JC, Farrar JT, Ferguson M, Forsythe LP, Freeman R, Gewandter JS, Gilron I, Goertz C, Grol-Prokopczyk H, Iyengar S, Jordan I, Kamp C, Kleykamp BA, Knowles RL, Langford DJ, Mackey S, Malamut R, Markman J, Martin KR, McNicol E, Patel KV, Rice ASC, Rowbotham M, Sandbrink F, Simon LS, Steiner DJ, Vollert J
Patient engagement in designing, conducting, and disseminating clinical pain research: IMMPACT recommended considerations. Pain. 2024 May 01; 165(5):1013-1028.
Patient engagement in designing, conducting, and disseminating clinical pain research: IMMPACT recommended considerations.
Hendry E, McCallister B, Elman DJ, Freeman R, Borsook D, Elman I
Validity of mental and physical stress models. Neurosci Biobehav Rev. 2024 Mar; 158:105566.
Validity of mental and physical stress models.
Millar Vernetti P, Norcliffe-Kaufmann L, Palma JA, Biaggioni I, Shibao CA, Peltier A, Freeman R, Gibbons C, Goldstein DS, Low PA, Singer W, Coon EA, Miglis MG, Wenning GK, Fanciulli A, Vernino S, Betensky RA, Kaufmann H
Phenoconversion in pure autonomic failure: a multicentre prospective longitudinal cohort study. Brain. 2024 Jul 05; 147(7):2440-2448.
Phenoconversion in pure autonomic failure: a multicentre prospective longitudinal cohort study.
Gibbons CH, Levine T, Adler C, Bellaire B, Wang N, Stohl J, Agarwal P, Aldridge GM, Barboi A, Evidente VGH, Galasko D, Geschwind MD, Gonzalez-Duarte A, Gil R, Gudesblatt M, Isaacson SH, Kaufmann H, Khemani P, Kumar R, Lamotte G, Liu AJ, McFarland NR, Miglis M, Reynolds A, Sahagian GA, Saint-Hillaire MH, Schwartzbard JB, Singer W, Soileau MJ, Vernino S, Yerstein O, Freeman R
Skin Biopsy Detection of Phosphorylated a-Synuclein in Patients With Synucleinopathies. JAMA. 2024 04 16; 331(15):1298-1306.
Skin Biopsy Detection of Phosphorylated a-Synuclein in Patients With Synucleinopathies.
Knoerl R, Mazzola E, Pazyra-Murphy M, Ryback B, Frazier AL, Freeman RL, Hammer M, LaCasce A, Ligibel J, Luskin MR, Berry DL, Segal RA
Exploring clinical markers of Axon degeneration processes in Chemotherapy-induced peripheral neuropathy among young adults receiving vincristine or paclitaxel. BMC Neurol. 2024 Sep 28; 24(1):366.
Exploring clinical markers of Axon degeneration processes in Chemotherapy-induced peripheral neuropathy among young adults receiving vincristine or paclitaxel.
Testing the autonomic nervous system. Handb Clin Neurol. 2013; 115:115-36.
Schestatsky P, Simis M, Freeman R, Pascual-Leone A, Fregni F
Non-invasive brain stimulation and the autonomic nervous system. Clin Neurophysiol. 2013 Sep; 124(9):1716-28.
Non-invasive brain stimulation and the autonomic nervous system.
Freeman R, McIntosh KA, Vijapurkar U, Thienel U
Topiramate and physiologic measures of nerve function in polyneuropathy. Acta Neurol Scand. 2007 Apr; 115(4):222-31.
Topiramate and physiologic measures of nerve function in polyneuropathy.
New and developing drugs for the treatment of neuropathic pain in diabetes. Curr Diab Rep. 2013 Aug; 13(4):500-8.
New and developing drugs for the treatment of neuropathic pain in diabetes.
Backonja MM, Attal N, Baron R, Bouhassira D, Drangholt M, Dyck PJ, Edwards RR, Freeman R, Gracely R, Haanpaa MH, Hansson P, Hatem SM, Krumova EK, Jensen TS, Maier C, Mick G, Rice AS, Rolke R, Treede RD, Serra J, Toelle T, Tugnoli V, Walk D, Walalce MS, Ware M, Yarnitsky D, Ziegler D
Value of quantitative sensory testing in neurological and pain disorders: NeuPSIG consensus. Pain. 2013 Sep; 154(9):1807-1819.
Value of quantitative sensory testing in neurological and pain disorders: NeuPSIG consensus.
a-Synuclein in cutaneous autonomic nerves. Neurology. 2013 Oct 29; 81(18):1604-10.
a-Synuclein in cutaneous autonomic nerves.
Knoerl R, Mazzola E, Frazier L, Freeman RL, Hammer M, LaCasce A, Ligibel J, Luskin MR, Berry D
Asia-Pacific journal of oncology nursing
Describing the minimally clinically important difference of a chemotherapy-induced peripheral neuropathy patient-reported outcome measure in young adults. Asia Pac J Oncol Nurs. 2025 Dec; 12:100656.
Describing the minimally clinically important difference of a chemotherapy-induced peripheral neuropathy patient-reported outcome measure in young adults.
High-pass filter characteristics of the baroreflex--a comparison of frequency domain and pharmacological methods. PLoS One. 2013; 8(11):e79513.
High-pass filter characteristics of the baroreflex--a comparison of frequency domain and pharmacological methods.
Gibbons CH, Bonyhay I, Benson A, Wang N, Freeman R
Structural and functional small fiber abnormalities in the neuropathic postural tachycardia syndrome. PLoS One. 2013; 8(12):e84716.
Structural and functional small fiber abnormalities in the neuropathic postural tachycardia syndrome.
Freeman R, Baron R, Bouhassira D, Cabrera J, Emir B
Sensory profiles of patients with neuropathic pain based on the neuropathic pain symptoms and signs. Pain. 2014 Feb; 155(2):367-376.
Sensory profiles of patients with neuropathic pain based on the neuropathic pain symptoms and signs.
Gibbons C, Cheshire W, Barboi A, Levine B, Olshansky B, Kinsella L, Claydon VE, Crandall C, Fink G, Joyner M, Macefield V, Norcliffe-Kaufmann L, Freeman R, Raj S, Stewart J, Sandroni P, Kaufmann H, Chelimsky T
Endovascular procedures for the treatment of autonomic dysfunction. Clin Auton Res. 2014 Feb; 24(1):1-2.
Endovascular procedures for the treatment of autonomic dysfunction.
Fillingim RB, Bruehl S, Dworkin RH, Dworkin SF, Loeser JD, Turk DC, Widerstrom-Noga E, Arnold L, Bennett R, Edwards RR, Freeman R, Gewandter J, Hertz S, Hochberg M, Krane E, Mantyh PW, Markman J, Neogi T, Ohrbach R, Paice JA, Porreca F, Rappaport BA, Smith SM, Smith TJ, Sullivan MD, Verne GN, Wasan AD, Wesselmann U
The ACTTION-American Pain Society Pain Taxonomy (AAPT): an evidence-based and multidimensional approach to classifying chronic pain conditions. J Pain. 2014 Mar; 15(3):241-9.
The ACTTION-American Pain Society Pain Taxonomy (AAPT): an evidence-based and multidimensional approach to classifying chronic pain conditions.
Diabetic autonomic neuropathy. Handb Clin Neurol. 2014; 126:63-79.
Treatment-induced neuropathy of diabetes: an acute, iatrogenic complication of diabetes. Brain. 2015 Jan; 138(Pt 1):43-52.
Treatment-induced neuropathy of diabetes: an acute, iatrogenic complication of diabetes.
Rao AD, Bonyhay I, Dankwa J, Baimas-George M, Kneen L, Ballatori S, Freeman R, Adler GK
Baroreflex Sensitivity Impairment During Hypoglycemia: Implications for Cardiovascular Control. Diabetes. 2016 Jan; 65(1):209-15.
Baroreflex Sensitivity Impairment During Hypoglycemia: Implications for Cardiovascular Control.
Clinical implications of delayed orthostatic hypotension: A 10-year follow-up study. Neurology. 2015 Oct 20; 85(16):1362-7.
Clinical implications of delayed orthostatic hypotension: A 10-year follow-up study.
Autonomic Neuropathy. Semin Neurol. 2015 Aug; 35(4):458-68.
Gibbons CH, Garcia J, Wang N, Shih LC, Freeman R
The diagnostic discrimination of cutaneous a-synuclein deposition in Parkinson disease. Neurology. 2016 Aug 02; 87(5):505-12.
The diagnostic discrimination of cutaneous a-synuclein deposition in Parkinson disease.
Taylor AM, Phillips K, Patel KV, Turk DC, Dworkin RH, Beaton D, Clauw DJ, Gignac MAM, Markman JD, Williams DA, Bujanover S, Burke LB, Carr DB, Choy EH, Conaghan PG, Cowan P, Farrar JT, Freeman R, Gewandter J, Gilron I, Goli V, Gover TD, Haddox JD, Kerns RD, Kopecky EA, Lee DA, Malamut R, Mease P, Rappaport BA, Simon LS, Singh JA, Smith SM, Strand V, Tugwell P, Vanhove GF, Veasley C, Walco GA, Wasan AD, Witter J
Assessment of physical function and participation in chronic pain clinical trials: IMMPACT/OMERACT recommendations. Pain. 2016 Sep; 157(9):1836-1850.
Assessment of physical function and participation in chronic pain clinical trials: IMMPACT/OMERACT recommendations.
Edwards RR, Dworkin RH, Turk DC, Angst MS, Dionne R, Freeman R, Hansson P, Haroutounian S, Arendt-Nielsen L, Attal N, Baron R, Brell J, Bujanover S, Burke LB, Carr D, Chappell AS, Cowan P, Etropolski M, Fillingim RB, Gewandter JS, Katz NP, Kopecky EA, Markman JD, Nomikos G, Porter L, Rappaport BA, Rice ASC, Scavone JM, Scholz J, Simon LS, Smith SM, Tobias J, Tockarshewsky T, Veasley C, Versavel M, Wasan AD, Wen W, Yarnitsky D
Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations. Pain. 2016 Sep; 157(9):1851-1871.
Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations.
Autonomic Rare Diseases Clinical Research Consortium
Hypoglycemia, mineralocorticoid receptor and autonomic control
Hypoglycemia, Cardiovascular Autonomic Function and Type 2 Diabetes Mellitus
HYPOGLYCEMIA AND AUTONOMIC NERVOUS SYSTEM FUNCTION
Freeman R, Wallace MS, Sweeney M, Backonja MM
Relationships Among Pain Quality, Pain Impact, and Overall Improvement in Patients with Postherpetic Neuralgia Treated with Gastroretentive Gabapentin. Pain Med. 2015 Oct; 16(10):2000-11.
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Effects of orthostatic hypotension on cognition in Parkinson disease. Neurology. 2017 Jan 03; 88(1):17-24.
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Gibbons CH, Schmidt P, Biaggioni I, Frazier-Mills C, Freeman R, Isaacson S, Karabin B, Kuritzky L, Lew M, Low P, Mehdirad A, Raj SR, Vernino S, Kaufmann H
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The treatment of postprandial hypotension in autonomic failure with 3,4-DL-threo-dihydroxyphenylserine.
Arora S, Smakowski P, Frykberg RG, Simeone LR, Freeman R, LoGerfo FW, Veves A
Differences in foot and forearm skin microcirculation in diabetic patients with and without neuropathy. Diabetes Care. 1998 Aug; 21(8):1339-44.
Differences in foot and forearm skin microcirculation in diabetic patients with and without neuropathy.
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Vasovagal syncope: the contributions of Sir William R. Gowers and Sir Thomas Lewis. Arch Neurol. 2001 Mar; 58(3):509-11.
Vasovagal syncope: the contributions of Sir William R. Gowers and Sir Thomas Lewis.
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The Potential Role of Sensory Testing, Skin Biopsy, and Functional Brain Imaging as Biomarkers in Chronic Pain Clinical Trials: IMMPACT Considerations. J Pain. 2017 07; 18(7):757-777.
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Differential impairment of the sudomotor and nociceptor axon-reflex in diabetic peripheral neuropathy. Muscle Nerve. 2006 Apr; 33(4):494-9.
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Does the chronic fatigue syndrome involve the autonomic nervous system? Am J Med. 1997 Apr; 102(4):357-64.
Does the chronic fatigue syndrome involve the autonomic nervous system?
Berghoff M, Kathpal M, Khan F, Skinner M, Falk R, Freeman R
Endothelial dysfunction precedes C-fiber abnormalities in primary (AL) amyloidosis. Ann Neurol. 2003 Jun; 53(6):725-30.
Endothelial dysfunction precedes C-fiber abnormalities in primary (AL) amyloidosis.
Disorders of sweating. Semin Neurol. 2003 Dec; 23(4):399-406.
Autonomic neurodermatology (Part I): Erythromelalgia, reflex sympathetic dystrophy, and livedo reticularis. Semin Neurol. 1992 Dec; 12(4):385-93.
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Neural and endothelial control of the microcirculation in diabetic peripheral neuropathy. Neurology. 2000 Mar 28; 54(6):1246-52.
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Sympathetic nerve activity in response to hypotensive stress in the postural tachycardia syndrome. Circulation. 2004 Nov 16; 110(20):3193-8.
Sympathetic nerve activity in response to hypotensive stress in the postural tachycardia syndrome.
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System identification of closed-loop cardiovascular control mechanisms: diabetic autonomic neuropathy.
Cornblath DR, Vinik A, Feldman E, Freeman R, Boulton AJ
Surgical decompression for diabetic sensorimotor polyneuropathy. Diabetes Care. 2007 Feb; 30(2):421-2.
Surgical decompression for diabetic sensorimotor polyneuropathy.
Sympathetic neural activity, sex dimorphism, and postural tachycardia syndrome. Ann Neurol. 2007 Apr; 61(4):332-9.
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Veves A, Akbari CM, Primavera J, Donaghue VM, Zacharoulis D, Chrzan JS, DeGirolami U, LoGerfo FW, Freeman R
Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease, and foot ulceration. Diabetes. 1998 Mar; 47(3):457-63.
Endothelial dysfunction and the expression of endothelial nitric oxide synthetase in diabetic neuropathy, vascular disease, and foot ulceration.
Apfel SC, Schwartz S, Adornato BT, Freeman R, Biton V, Rendell M, Vinik A, Giuliani M, Stevens JC, Barbano R, Dyck PJ
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Autonomic and electrocardiographic findings in Parkinson's disease.
Freeman R, Roberts MS, Friedman LS, Broadbridge C
Autonomic function and human immunodeficiency virus infection. Neurology. 1990 Apr; 40(4):575-80.
Autonomic function and human immunodeficiency virus infection.
Low PA, Gilden JL, Freeman R, Sheng KN, McElligott MA
Efficacy of midodrine for neurogenic orthostatic hypotension. Reply. JAMA. 1997 Aug 06; 278(5):388.
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Risk MR, Lirofonis V, Armentano RL, Freeman R
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A biphasic model of limb venous compliance: a comparison with linear and exponential models.
Berghoff M, Kathpal M, Kilo S, Hilz MJ, Freeman R
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Vascular and neural mechanisms of ACh-mediated vasodilation in the forearm cutaneous microcirculation.
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High blood pressure and decreased heart rate variability in the Cuban epidemic neuropathy. J Neurol Neurosurg Psychiatry. 2002 Jul; 73(1):71-2.
High blood pressure and decreased heart rate variability in the Cuban epidemic neuropathy.
Ziegler D, Low PA, Litchy WJ, Boulton AJ, Vinik AI, Freeman R, Samigullin R, Tritschler H, Munzel U, Maus J, Schütte K, Dyck PJ
Efficacy and safety of antioxidant treatment with a-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial. Diabetes Care. 2011 Sep; 34(9):2054-60.
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The treatment of orthostatic hypotension with dihydroxyphenylserine. Clin Neuropharmacol. 1991 Aug; 14(4):296-304.
The treatment of orthostatic hypotension with dihydroxyphenylserine.
Spindle coma secondary to vasovagal syncope. Epilepsy Behav. 2002 Jun; 3(3):289-291.
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Orthostatic dyspnea: a neglected symptom of orthostatic hypotension. Clin Auton Res. 2005 Feb; 15(1):40-4.
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Delayed orthostatic hypotension: a frequent cause of orthostatic intolerance. Neurology. 2006 Jul 11; 67(1):28-32.
Delayed orthostatic hypotension: a frequent cause of orthostatic intolerance.
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Cutaneous Alpha-Synuclein From Paraffin Embedded Autopsy Specimens in Parkinson's Disease. J Parkinsons Dis. 2017; 7(3):503-509.
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Diabetic autonomic neuropathy. Semin Neurol. 2003 Dec; 23(4):365-72.
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Cutaneous Autonomic Pilomotor Testing to Unveil the Role of Neuropathy Progression in Early Parkinson's Disease (CAPTURE PD): Protocol for a Multicenter Study. Front Neurol. 2017; 8:212.
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Efficacy, safety, and tolerability of pregabalin treatment for painful diabetic peripheral neuropathy: findings from seven randomized, controlled trials across a range of doses. Diabetes Care. 2008 Jul; 31(7):1448-54.
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Highlights in clinical autonomic neurosciences: vasovagal syncope - insights on diagnosis, pathophysiology and treatment. Auton Neurosci. 2012 May 21; 168(1-2):1-3.
Highlights in clinical autonomic neurosciences: vasovagal syncope - insights on diagnosis, pathophysiology and treatment.
Brown FM, Brink SJ, Freeman R, Rabinowe SL
Anti-sympathetic nervous system autoantibodies. Diminished catecholamines with orthostasis. Diabetes. 1989 Jul; 38(7):938-41.
Anti-sympathetic nervous system autoantibodies. Diminished catecholamines with orthostasis.
Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I, Cheshire WP, Chelimsky T, Cortelli P, Gibbons CH, Goldstein DS, Hainsworth R, Hilz MJ, Jacob G, Kaufmann H, Jordan J, Lipsitz LA, Levine BD, Low PA, Mathias C, Raj SR, Robertson D, Sandroni P, Schatz I, Schondorff R, Stewart JM, van Dijk JG
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Kaufmann H, Malamut R, Norcliffe-Kaufmann L, Rosa K, Freeman R
The Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale. Clin Auton Res. 2012 Apr; 22(2):79-90.
The Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale.
Siepmann T, Gibbons CH, Illigens BM, Lafo JA, Brown CM, Freeman R
Quantitative pilomotor axon reflex test: a novel test of pilomotor function. Arch Neurol. 2012 Nov; 69(11):1488-92.
Quantitative pilomotor axon reflex test: a novel test of pilomotor function.
The treatment of neuropathic pain. CNS Spectr. 2005 Sep; 10(9):698-706.
Farquhar WB, Hunt BE, Taylor JA, Darling SE, Freeman R
American journal of physiology. Heart and circulatory physiology
Blood volume and its relation to peak O(2) consumption and physical activity in patients with chronic fatigue. Am J Physiol Heart Circ Physiol. 2002 Jan; 282(1):H66-71.
Blood volume and its relation to peak O(2) consumption and physical activity in patients with chronic fatigue.
Syncope and the history of nervous influences on the heart. Arch Neurol. 2003 Feb; 60(2):282-7.
Syncope and the history of nervous influences on the heart.
Sphincter electromyography and multiple system atrophy. Muscle Nerve. 2003 Jul; 28(1):18-26.
Sphincter electromyography and multiple system atrophy.
Treatment of orthostatic hypotension. Semin Neurol. 2003 Dec; 23(4):435-42.
Dotson S, Freeman R, Failing HJ, Adler GK
Hypoglycemia increases serum interleukin-6 levels in healthy men and women. Diabetes Care. 2008 Jun; 31(6):1222-3.
Hypoglycemia increases serum interleukin-6 levels in healthy men and women.
Current pharmacologic treatment for orthostatic hypotension. Clin Auton Res. 2008 Mar; 18 Suppl 1:14-8.
Current pharmacologic treatment for orthostatic hypotension.
Highlights in clinical autonomic neuroscience: latest developments in the early detection of diabetic autonomic neuropathy. Auton Neurosci. 2012 Apr 03; 167(1-2):4-6.
Highlights in clinical autonomic neuroscience: latest developments in the early detection of diabetic autonomic neuropathy.
Goldstein DS, Holmes C, Kaufmann H, Freeman R
Clinical pharmacokinetics of the norepinephrine precursor L-threo-DOPS in primary chronic autonomic failure. Clin Auton Res. 2004 Dec; 14(6):363-8.
Clinical pharmacokinetics of the norepinephrine precursor L-threo-DOPS in primary chronic autonomic failure.
Cardiovascular manifestations of autonomic epilepsy. Clin Auton Res. 2006 Feb; 16(1):12-7.
Cardiovascular manifestations of autonomic epilepsy.
Combined immunomodulatory therapy in autoimmune autonomic ganglionopathy. Arch Neurol. 2008 Feb; 65(2):213-7.
Combined immunomodulatory therapy in autoimmune autonomic ganglionopathy.
Gibbons CH, Illigens BM, Wang N, Freeman R
Quantification of sudomotor innervation: a comparison of three methods. Muscle Nerve. 2010 Jul; 42(1):112-9.
Quantification of sudomotor innervation: a comparison of three methods.
Adler GK, Bonyhay I, Curren V, Waring E, Freeman R
Diabetic medicine : a journal of the British Diabetic Association
Hypoglycaemia increases aldosterone in a dose-dependent fashion. Diabet Med. 2010 Nov; 27(11):1250-5.
Hypoglycaemia increases aldosterone in a dose-dependent fashion.
Gibbons CH, Adler GK, Bonyhay I, Freeman R
Experimental hypoglycemia is a human model of stress-induced hyperalgesia. Pain. 2012 Nov; 153(11):2204-2209.
Experimental hypoglycemia is a human model of stress-induced hyperalgesia.
Author response: Effects of orthostatic hypotension on cognition in Parkinson disease. Neurology. 2017 11 14; 89(20):2122.
Author response: Effects of orthostatic hypotension on cognition in Parkinson disease.
Autonomic epilepsy. Semin Neurol. 1995 Jun; 15(2):158-66.
The chronic fatigue syndrome is a disease of the autonomic nervous system. Sometimes. Clin Auton Res. 2002 Aug; 12(4):231-3.
The chronic fatigue syndrome is a disease of the autonomic nervous system. Sometimes.
Vinik AI, Maser RE, Mitchell BD, Freeman R
Diabetic autonomic neuropathy. Diabetes Care. 2003 May; 26(5):1553-79.
The evaluation of small fiber function-autonomic and quantitative sensory testing. Neurol Clin. 2004 Aug; 22(3):683-702, vii.
The evaluation of small fiber function-autonomic and quantitative sensory testing.
Gibbons CH, Centi J, Vernino S, Freeman R
Autoimmune autonomic ganglionopathy with reversible cognitive impairment. Arch Neurol. 2012 Apr; 69(4):461-6.
Autoimmune autonomic ganglionopathy with reversible cognitive impairment.
Phantom sweating: a novel autonomic paresthesia. Clin Auton Res. 2008 Dec; 18(6):352-4.
Phantom sweating: a novel autonomic paresthesia.
Walsh RR, Krismer F, Galpern WR, Wenning GK, Low PA, Halliday G, Koroshetz WJ, Holton J, Quinn NP, Rascol O, Shaw LM, Eidelberg D, Bower P, Cummings JL, Abler V, Biedenharn J, Bitan G, Brooks DJ, Brundin P, Fernandez H, Fortier P, Freeman R, Gasser T, Hewitt A, Höglinger GU, Huentelman MJ, Jensen PH, Jeromin A, Kang UJ, Kaufmann H, Kellerman L, Khurana V, Klockgether T, Kim WS, Langer C, LeWitt P, Masliah E, Meissner W, Melki R, Ostrowitzki S, Piantadosi S, Poewe W, Robertson D, Roemer C, Schenk D, Schlossmacher M, Schmahmann JD, Seppi K, Shih L, Siderowf A, Stebbins GT, Stefanova N, Tsuji S, Sutton S, Zhang J
Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting. Neurology. 2018 01 09; 90(2):74-82.
Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting.
Diabetic neuropathy: a cross-sectional study of the relationships among tests of neurophysiology. Diabetes Care. 2010 Dec; 33(12):2629-34.
Diabetic neuropathy: a cross-sectional study of the relationships among tests of neurophysiology.
Antibody titers predict clinical features of autoimmune autonomic ganglionopathy. Auton Neurosci. 2009 Mar 12; 146(1-2):8-12.
Antibody titers predict clinical features of autoimmune autonomic ganglionopathy.
Quantification of sweat gland innervation: a clinical-pathologic correlation. Neurology. 2009 Apr 28; 72(17):1479-86.
Quantification of sweat gland innervation: a clinical-pathologic correlation.
Cardiovascular autonomic tests in diabetic patients with gastroparesis. Arq Neuropsiquiatr. 1997 Jun; 55(2):227-30.
Cardiovascular autonomic tests in diabetic patients with gastroparesis.
Norcliffe-Kaufmann L, Kaufmann H, Palma JA, Shibao CA, Biaggioni I, Peltier AC, Singer W, Low PA, Goldstein DS, Gibbons CH, Freeman R, Robertson D
Orthostatic heart rate changes in patients with autonomic failure caused by neurodegenerative synucleinopathies. Ann Neurol. 2018 03; 83(3):522-531.
Orthostatic heart rate changes in patients with autonomic failure caused by neurodegenerative synucleinopathies.
Autonomic neurodermatology (Part II): Disorders of sweating and flushing. Semin Neurol. 1992 Dec; 12(4):394-407.
Autonomic neurodermatology (Part II): Disorders of sweating and flushing.
Maser RE, Mitchell BD, Vinik AI, Freeman R
The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis. Diabetes Care. 2003 Jun; 26(6):1895-901.
The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis.
Berger AR, Bradley WG, Brannagan TH, Busis NA, Cros DP, Dalakas MC, Danon MJ, Donofrio P, Engel WK, England JD, Feldman EL, Freeman RL, Kinsella LJ, Lacomis D, Latov N, Menkes DL, Sander HW, Thomas FP, Triggs WJ, Windebank AJ, Wolfe GI
Guidelines for the diagnosis and treatment of chronic inflammatory demyelinating polyneuropathy. J Peripher Nerv Syst. 2003 Dec; 8(4):282-4.
Guidelines for the diagnosis and treatment of chronic inflammatory demyelinating polyneuropathy.
Highlights in clinical autonomic neurosciences: Orthostatic hypotension: insights into risks and causes. Auton Neurosci. 2012 Sep 25; 170(1-2):3-4.
Highlights in clinical autonomic neurosciences: Orthostatic hypotension: insights into risks and causes.
Challenges in developing novel therapies for peripheral neuropathies: a summary of The Foundation for Peripheral Neuropathy Scientific Symposium 2012. J Peripher Nerv Syst. 2013 Mar; 18(1):1-6.
Challenges in developing novel therapies for peripheral neuropathies: a summary of The Foundation for Peripheral Neuropathy Scientific Symposium 2012.
Blaber AP, Bondar RL, Stein F, Dunphy PT, Moradshahi P, Kassam MS, Freeman R
Complexity of middle cerebral artery blood flow velocity: effects of tilt and autonomic failure. Am J Physiol. 1997 11; 273(5):H2209-16.
Complexity of middle cerebral artery blood flow velocity: effects of tilt and autonomic failure.