CNS3CharlesSerhanCharles Nicholas Serhan, Ph.D.42.33510370000000-71.1061649000000017417Serhan, CharlesNicholas617/525-5001Simon Gelman Professor of Anaesthesiacatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson10377187Hachicha M, Pouliot M, Petasis NA, Serhan CNThe Journal of experimental medicineLipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor 1alpha-initiated neutrophil responses and trafficking: regulators of a cytokine-chemokine axis. J Exp Med. 1999 Jun 21; 189(12):1923-30.J Exp Med1999-06-21T00:00:001999Lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor 1alpha-initiated neutrophil responses and trafficking: regulators of a cytokine-chemokine axis.11238602Serhan CN, Fierro IM, Chiang N, Pouliot MJournal of immunology (Baltimore, Md. : 1950)Cutting edge: nociceptin stimulates neutrophil chemotaxis and recruitment: inhibition by aspirin-triggered-15-epi-lipoxin A4. J Immunol. 2001 Mar 15; 166(6):3650-4.J Immunol2001-03-15T00:00:002001Cutting edge: nociceptin stimulates neutrophil chemotaxis and recruitment: inhibition by aspirin-triggered-15-epi-lipoxin A4.Authorship 10487193Authorship 10496706Authorship 1049073629455574Halade GV, Kain V, Serhan CNFASEB journal : official publication of the Federation of American Societies for Experimental BiologyImmune responsive resolvin D1 programs myocardial infarction-induced cardiorenal syndrome in heart failure. FASEB J. 2018 07; 32(7):3717-3729.FASEB J2018-02-13T00:00:002018Immune responsive resolvin D1 programs myocardial infarction-induced cardiorenal syndrome in heart failure.29500456Sima C, Montero E, Nguyen D, Freire M, Norris P, Serhan CN, Van Dyke TEScientific reportsAuthor Correction: ERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance. Sci Rep. 2018 Mar 02; 8(1):4143.Sci Rep2018-03-02T00:00:002018Author Correction: ERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance.10430612Chiang N, Gronert K, Clish CB, O'Brien JA, Freeman MW, Serhan CNThe Journal of clinical investigationLeukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion. J Clin Invest. 1999 Aug; 104(3):309-16.J Clin Invest1999-08-01T00:00:001999Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion.12172542Levy BD, De Sanctis GT, Devchand PR, Kim E, Ackerman K, Schmidt BA, Szczeklik W, Drazen JM, Serhan CNNature medicineMulti-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4). Nat Med. 2002 Sep; 8(9):1018-23.Nat Med2002-08-12T00:00:002002Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4).Authorship 105057410Authorship 10529744Authorship 1050702229524409Norris PC, Serhan CNBiochemical and biophysical research communicationsMetabololipidomic profiling of functional immunoresolvent clusters and eicosanoids in mammalian tissues. Biochem Biophys Res Commun. 2018 10 07; 504(3):553-561.Biochem Biophys Res Commun2018-03-15T00:00:002018Metabololipidomic profiling of functional immunoresolvent clusters and eicosanoids in mammalian tissues.29523657Sham HP, Walker KH, Abdulnour RE, Krishnamoorthy N, Douda DN, Norris PC, Barkas I, Benito-Figueroa S, Colby JK, Serhan CN, Levy BDJournal of immunology (Baltimore, Md. : 1950)15-epi-Lipoxin A4, Resolvin D2, and Resolvin D3 Induce NF-?B Regulators in Bacterial Pneumonia. J Immunol. 2018 04 15; 200(8):2757-2766.J Immunol2018-03-09T00:00:00201815-epi-Lipoxin A4, Resolvin D2, and Resolvin D3 Induce NF-?B Regulators in Bacterial Pneumonia.29511119Halade GV, Norris PC, Kain V, Serhan CN, Ingle KAScience signalingSplenic leukocytes define the resolution of inflammation in heart failure. Sci Signal. 2018 03 06; 11(520).Sci Signal2018-03-06T00:00:002018Splenic leukocytes define the resolution of inflammation in heart failure.6253562Serhan CN, Korchak HM, Weissmann GJournal of immunology (Baltimore, Md. : 1950)PGBX, a prostagandin derivative, mimics the action of the calcium ionophore A23187 on human neutrophils. J Immunol. 1980 Nov; 125(5):2020-4.J Immunol1980-11-01T00:00:001980PGBX, a prostagandin derivative, mimics the action of the calcium ionophore A23187 on human neutrophils.6328909Weissmann G, Serhan C, Korchak HM, Smolen JEAdvances in experimental medicine and biologyMechanisms of mediator release from neutrophils. Adv Exp Med Biol. 1984; 172:527-52.Adv Exp Med Biol1984-01-01T00:00:001984Mechanisms of mediator release from neutrophils.Authorship 10533799Authorship 10542048Authorship 1053292629571326de la Rosa X, Norris PC, Chiang N, Rodriguez AR, Spur BW, Serhan CNThe American journal of pathologyIdentification and Complete Stereochemical Assignments of the New Resolvin Conjugates in Tissue Regeneration in Human Tissues that Stimulate Proresolving Phagocyte Functions and Tissue Regeneration. Am J Pathol. 2018 04; 188(4):950-966.Am J Pathol2018-04-01T00:00:002018Identification and Complete Stereochemical Assignments of the New Resolvin Conjugates in Tissue Regeneration in Human Tissues that Stimulate Proresolving Phagocyte Functions and Tissue Regeneration.29559341Hellmann J, Sansbury BE, Wong B, Li X, Singh M, Nuutila K, Chiang N, Eriksson E, Serhan CN, Spite MThe Journal of investigative dermatologyBiosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair. J Invest Dermatol. 2018 09; 138(9):2051-2060.J Invest Dermatol2018-03-17T00:00:002018Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair.29563331Motwani MP, Colas RA, George MJ, Flint JD, Dalli J, Richard-Loendt A, De Maeyer RP, Serhan CN, Gilroy DWJCI insightPro-resolving mediators promote resolution in a human skin model of UV-killed Escherichia coli-driven acute inflammation. JCI Insight. 2018 03 22; 3(6).JCI Insight2018-03-22T00:00:002018Pro-resolving mediators promote resolution in a human skin model of UV-killed Escherichia coli-driven acute inflammation.3365446Brasseur R, Deleers M, Ruysschaert JM, Samuelsson B, Serhan CNBiochimica et biophysica actaConformational analysis of lipoxin A, lipoxin B and their trans-isomers. Biochim Biophys Acta. 1988 May 22; 960(2):245-52.Biochim Biophys Acta1988-05-22T00:00:001988Conformational analysis of lipoxin A, lipoxin B and their trans-isomers.3782800Ramstedt U, Serhan CN, Nicolaou KC, Webber SE, Wigzell H, Samuelsson BJournal of immunology (Baltimore, Md. : 1950)Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: studies on stereospecificity of inhibition and mode of action. J Immunol. 1987 Jan 01; 138(1):266-70.J Immunol1987-01-01T00:00:001987Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: studies on stereospecificity of inhibition and mode of action.6303077Serhan CN, Smolen JE, Korchak HM, Weissmann GAdvances in prostaglandin, thromboxane, and leukotriene researchLeukotriene B4 is a complete secretagogue in human neutrophils: Ca2+ translocation in liposomes and kinetics of neutrophil activation. Adv Prostaglandin Thromboxane Leukot Res. 1983; 11:53-63.Adv Prostaglandin Thromboxane Leukot Res1983-01-01T00:00:001983Leukotriene B4 is a complete secretagogue in human neutrophils: Ca2+ translocation in liposomes and kinetics of neutrophil activation.9353124Levy BD, Petasis NA, Serhan CNNaturePolyisoprenyl phosphates in intracellular signalling. Nature. 1997 Oct 30; 389(6654):985-90.Nature1997-10-30T00:00:001997Polyisoprenyl phosphates in intracellular signalling.10881166Serhan CNNature immunologyPreventing injury from within, using selective cPLA2 inhibitors. Nat Immunol. 2000 Jul; 1(1):13-5.Nat Immunol2000-07-01T00:00:002000Preventing injury from within, using selective cPLA2 inhibitors.17419455Arita M, Serhan CNTanpakushitsu kakusan koso. Protein, nucleic acid, enzyme[Novel chemical mediators in the resolution of inflammation]. Tanpakushitsu Kakusan Koso. 2007 Apr; 52(4):348-54.Tanpakushitsu Kakusan Koso2007-04-01T00:00:002007[Novel chemical mediators in the resolution of inflammation].17420269Ashton AW, Mukherjee S, Nagajyothi FN, Huang H, Braunstein VL, Desruisseaux MS, Factor SM, Lopez L, Berman JW, Wittner M, Scherer PE, Capra V, Coffman TM, Serhan CN, Gotlinger K, Wu KK, Weiss LM, Tanowitz HBThe Journal of experimental medicineThromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection. J Exp Med. 2007 Apr 16; 204(4):929-40.J Exp Med2007-04-09T00:00:002007Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection.17906612Yacoubian S, Serhan CNNature clinical practice. RheumatologyNew endogenous anti-inflammatory and proresolving lipid mediators: implications for rheumatic diseases. Nat Clin Pract Rheumatol. 2007 Oct; 3(10):570-9; quiz 1 p following 589.Nat Clin Pract Rheumatol2007-10-01T00:00:002007New endogenous anti-inflammatory and proresolving lipid mediators: implications for rheumatic diseases.18559988Merched AJ, Ko K, Gotlinger KH, Serhan CN, Chan LFASEB journal : official publication of the Federation of American Societies for Experimental BiologyAtherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators. FASEB J. 2008 Oct; 22(10):3595-606.FASEB J2008-06-17T00:00:002008Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators.11478391Serhan CNArchivum immunologiae et therapiae experimentalisLipoxins and aspirin-triggered 15-epi-lipoxins are endogenous components of antiinflammation: emergence of the counterregulatory side. Arch Immunol Ther Exp (Warsz). 2001; 49(3):177-88.Arch Immunol Ther Exp (Warsz)2001-01-01T00:00:002001Lipoxins and aspirin-triggered 15-epi-lipoxins are endogenous components of antiinflammation: emergence of the counterregulatory side.Authorship 111685Authorship 1058419229679485Dalli J, Serhan CNBritish journal of pharmacologyIdentification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology. Br J Pharmacol. 2019 04; 176(8):1024-1037.Br J Pharmacol2018-06-03T00:00:002018Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology.15722568Lu Y, Hong S, Tjonahen E, Serhan CNJournal of lipid researchMediator-lipidomics: databases and search algorithms for PUFA-derived mediators. J Lipid Res. 2005 Apr; 46(4):790-802.J Lipid Res2005-02-01T00:00:002005Mediator-lipidomics: databases and search algorithms for PUFA-derived mediators.18568027Haworth O, Cernadas M, Yang R, Serhan CN, Levy BDNature immunologyResolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation. Nat Immunol. 2008 Aug; 9(8):873-9.Nat Immunol2008-06-22T00:00:002008Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation.2494071Brezinski ME, Gimbrone MA, Nicolaou KC, Serhan CNFEBS lettersLipoxins stimulate prostacyclin generation by human endothelial cells. FEBS Lett. 1989 Mar 13; 245(1-2):167-72.FEBS Lett1989-03-13T00:00:001989Lipoxins stimulate prostacyclin generation by human endothelial cells.19498085Ye RD, Boulay F, Wang JM, Dahlgren C, Gerard C, Parmentier M, Serhan CN, Murphy PMPharmacological reviewsInternational Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family. Pharmacol Rev. 2009 Jun; 61(2):119-61.Pharmacol Rev2009-06-04T00:00:002009International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family.Authorship 1060774429702100Lippestad M, Hodges RR, Utheim TP, Serhan CN, Dartt DAExperimental eye researchSignaling pathways activated by resolvin E1 to stimulate mucin secretion and increase intracellular Ca2+ in cultured rat conjunctival goblet cells. Exp Eye Res. 2018 08; 173:64-72.Exp Eye Res2018-04-25T00:00:002018Signaling pathways activated by resolvin E1 to stimulate mucin secretion and increase intracellular Ca2+ in cultured rat conjunctival goblet cells.2555281Serhan CN, Reardon EFree radical research communications15-Hydroxyeicosatetraenoic acid inhibits superoxide anion generation by human neutrophils: relationship to lipoxin production. Free Radic Res Commun. 1989; 7(3-6):341-5.Free Radic Res Commun1989-01-01T00:00:00198915-Hydroxyeicosatetraenoic acid inhibits superoxide anion generation by human neutrophils: relationship to lipoxin production.19906641Ohira T, Arita M, Omori K, Recchiuti A, Van Dyke TE, Serhan CNThe Journal of biological chemistryResolvin E1 receptor activation signals phosphorylation and phagocytosis. J Biol Chem. 2010 Jan 29; 285(5):3451-61.J Biol Chem2009-11-11T00:00:002009Resolvin E1 receptor activation signals phosphorylation and phagocytosis.22171045Park CK, Xu ZZ, Liu T, Lü N, Serhan CN, Ji RRThe Journal of neuroscience : the official journal of the Society for NeuroscienceResolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1. J Neurosci. 2011 Dec 14; 31(50):18433-8.J Neurosci2011-12-14T00:00:002011Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.23438748Dalli J, Winkler JW, Colas RA, Arnardottir H, Cheng CY, Chiang N, Petasis NA, Serhan CNChemistry & biologyResolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents. Chem Biol. 2013 Feb 21; 20(2):188-201.Chem Biol2013-02-21T00:00:002013Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents.8250832Romano M, Chen XS, Takahashi Y, Yamamoto S, Funk CD, Serhan CNThe Biochemical journalLipoxin synthase activity of human platelet 12-lipoxygenase. Biochem J. 1993 Nov 15; 296 ( Pt 1):127-33.Biochem J1993-11-15T00:00:001993Lipoxin synthase activity of human platelet 12-lipoxygenase.17767360Bannenberg G, Arita M, Serhan CNTheScientificWorldJournalEndogenous receptor agonists: resolving inflammation. ScientificWorldJournal. 2007 Sep 01; 7:1440-62.ScientificWorldJournal2007-09-01T00:00:002007Endogenous receptor agonists: resolving inflammation.Authorship 10647387Authorship 10659801Authorship 1064265929765320Zhang L, Terrando N, Xu ZZ, Bang S, Jordt SE, Maixner W, Serhan CN, Ji RRFrontiers in pharmacologyDistinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice. Front Pharmacol. 2018; 9:412.Front Pharmacol2018-05-01T00:00:002018Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice.29757195Serhan CN, Levy BDThe Journal of clinical investigationResolvins in inflammation: emergence of the pro-resolving superfamily of mediators. J Clin Invest. 2018 07 02; 128(7):2657-2669.J Clin Invest2018-05-14T00:00:002018Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators.29730187Sorokin AV, Norris PC, English JT, Dey AK, Chaturvedi A, Baumer Y, Silverman J, Playford MP, Serhan CN, Mehta NNJournal of clinical lipidologyIdentification of proresolving and inflammatory lipid mediators in human psoriasis. J Clin Lipidol. 2018 Jul - Aug; 12(4):1047-1060.J Clin Lipidol2018-04-06T00:00:002018Identification of proresolving and inflammatory lipid mediators in human psoriasis.17114001Tjonahen E, Oh SF, Siegelman J, Elangovan S, Percarpio KB, Hong S, Arita M, Serhan CNChemistry & biologyResolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis. Chem Biol. 2006 Nov; 13(11):1193-202.Chem Biol2006-11-01T00:00:002006Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis.18292578Hong S, Porter TF, Lu Y, Oh SF, Pillai PS, Serhan CNJournal of immunology (Baltimore, Md. : 1950)Resolvin E1 metabolome in local inactivation during inflammation-resolution. J Immunol. 2008 Mar 01; 180(5):3512-9.J Immunol2008-03-01T00:00:002008Resolvin E1 metabolome in local inactivation during inflammation-resolution.18806821Herrera BS, Ohira T, Gao L, Omori K, Yang R, Zhu M, Muscara MN, Serhan CN, Van Dyke TE, Gyurko RBritish journal of pharmacologyAn endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption. Br J Pharmacol. 2008 Dec; 155(8):1214-23.Br J Pharmacol2008-09-22T00:00:002008An endogenous regulator of inflammation, resolvin E1, modulates osteoclast differentiation and bone resorption.19103881Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS, Porter TF, Oh SF, Spite MThe Journal of experimental medicineMaresins: novel macrophage mediators with potent antiinflammatory and proresolving actions. J Exp Med. 2009 Jan 16; 206(1):15-23.J Exp Med2008-12-22T00:00:002008Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions.20142487Hattori H, Subramanian KK, Sakai J, Jia Y, Li Y, Porter TF, Loison F, Sarraj B, Kasorn A, Jo H, Blanchard C, Zirkle D, McDonald D, Pai SY, Serhan CN, Luo HRProceedings of the National Academy of Sciences of the United States of AmericaSmall-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3546-51.Proc Natl Acad Sci U S A2010-02-08T00:00:002010Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis.21286796Pillai PS, Leeson S, Porter TF, Owens CD, Kim JM, Conte MS, Serhan CN, Gelman SInflammationChemical mediators of inflammation and resolution in post-operative abdominal aortic aneurysm patients. Inflammation. 2012 Feb; 35(1):98-113.Inflammation2012-02-01T00:00:002012Chemical mediators of inflammation and resolution in post-operative abdominal aortic aneurysm patients.2959121Serhan CN, Nicolaou KC, Webber SE, Veale CA, Haeggström J, Puustinen TJ, Samuelsson BAdvances in prostaglandin, thromboxane, and leukotriene researchStereochemistry and biosynthesis of lipoxins. Adv Prostaglandin Thromboxane Leukot Res. 1987; 17A:90-3.Adv Prostaglandin Thromboxane Leukot Res1987-01-01T00:00:001987Stereochemistry and biosynthesis of lipoxins.12088274Levy BD, Serhan CNCellular and molecular life sciences : CMLSPolyisoprenyl phosphates: natural antiinflammatory lipid signals. Cell Mol Life Sci. 2002 May; 59(5):729-41.Cell Mol Life Sci2002-05-01T00:00:002002Polyisoprenyl phosphates: natural antiinflammatory lipid signals.12615958Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Nicosia S, Serhan CN, Shimizu T, Yokomizo TPharmacological reviewsInternational Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors. Pharmacol Rev. 2003 Mar; 55(1):195-227.Pharmacol Rev2003-03-01T00:00:002003International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors.12751730Levy BD, De Sanctis GT, Devchand PR, Kim E, Ackerman K, Schmidt B, Szczeklik W, Drazen JM, Serhan CNAdvances in experimental medicine and biologyLipoxins and aspirin-triggered lipoxins in airway responses. Adv Exp Med Biol. 2003; 525:19-23.Adv Exp Med Biol2003-01-01T00:00:002003Lipoxins and aspirin-triggered lipoxins in airway responses.12806051Serhan CN, Chiang NTheScientificWorldJournalLipid-derived mediators in endogenous anti-inflammation and resolution: lipoxins and aspirin-triggered 15-epi-lipoxins. ScientificWorldJournal. 2002 Jan 22; 2:169-204.ScientificWorldJournal2002-01-22T00:00:002002Lipid-derived mediators in endogenous anti-inflammation and resolution: lipoxins and aspirin-triggered 15-epi-lipoxins.21653234Palmer CD, Mancuso CJ, Weiss JP, Serhan CN, Guinan EC, Levy OJournal of leukocyte biology17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli. J Leukoc Biol. 2011 Sep; 90(3):459-70.J Leukoc Biol2011-06-07T00:00:00201117(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli.23185003Jones CN, Dalli J, Dimisko L, Wong E, Serhan CN, Irimia DProceedings of the National Academy of Sciences of the United States of AmericaMicrofluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):20560-5.Proc Natl Acad Sci U S A2012-11-26T00:00:002012Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions.23197111Buckley CD, Gilroy DW, Serhan CN, Stockinger B, Tak PPNature reviews. ImmunologyThe resolution of inflammation. Nat Rev Immunol. 2013 01; 13(1):59-66.Nat Rev Immunol2012-11-30T00:00:002012The resolution of inflammation.15471991Chiang N, Bermudez EA, Ridker PM, Hurwitz S, Serhan CNProceedings of the National Academy of Sciences of the United States of AmericaAspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial. Proc Natl Acad Sci U S A. 2004 Oct 19; 101(42):15178-83.Proc Natl Acad Sci U S A2004-10-07T00:00:002004Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial.16098719Petasis NA, Akritopoulou-Zanze I, Fokin VV, Bernasconi G, Keledjian R, Yang R, Uddin J, Nagulapalli KC, Serhan CNProstaglandins, leukotrienes, and essential fatty acidsDesign, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins. Prostaglandins Leukot Essent Fatty Acids. 2005 Sep-Oct; 73(3-4):301-21.Prostaglandins Leukot Essent Fatty Acids2005-09-01T00:00:002005Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins.16424216Serhan CN, Gotlinger K, Hong S, Lu Y, Siegelman J, Baer T, Yang R, Colgan SP, Petasis NAJournal of immunology (Baltimore, Md. : 1950)Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes. J Immunol. 2006 Feb 01; 176(3):1848-59.J Immunol2006-02-01T00:00:002006Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes.2117277Brezinski ME, Serhan CNProceedings of the National Academy of Sciences of the United States of AmericaSelective incorporation of (15S)-hydroxyeicosatetraenoic acid in phosphatidylinositol of human neutrophils: agonist-induced deacylation and transformation of stored hydroxyeicosanoids. Proc Natl Acad Sci U S A. 1990 Aug; 87(16):6248-52.Proc Natl Acad Sci U S A1990-08-01T00:00:001990Selective incorporation of (15S)-hydroxyeicosatetraenoic acid in phosphatidylinositol of human neutrophils: agonist-induced deacylation and transformation of stored hydroxyeicosanoids.2155925Serhan CN, Sheppard KAThe Journal of clinical investigationLipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro. J Clin Invest. 1990 Mar; 85(3):772-80.J Clin Invest1990-03-01T00:00:001990Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro.2162850Nigam S, Fiore S, Luscinskas FW, Serhan CNJournal of cellular physiologyLipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion. J Cell Physiol. 1990 Jun; 143(3):512-23.J Cell Physiol1990-06-01T00:00:001990Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion.10667343Serhan CN, Takano T, Clish CB, Gronert K, Petasis NAdvances in experimental medicine and biologyAspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogs inhibit neutrophil-mediated changes in vascular permeability. Adv Exp Med Biol. 1999; 469:287-93.Adv Exp Med Biol1999-01-01T00:00:001999Aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogs inhibit neutrophil-mediated changes in vascular permeability.11805195Fierro IM, Kutok JL, Serhan CNThe Journal of pharmacology and experimental therapeuticsNovel lipid mediator regulators of endothelial cell proliferation and migration: aspirin-triggered-15R-lipoxin A(4) and lipoxin A(4). J Pharmacol Exp Ther. 2002 Feb; 300(2):385-92.J Pharmacol Exp Ther2002-02-01T00:00:002002Novel lipid mediator regulators of endothelial cell proliferation and migration: aspirin-triggered-15R-lipoxin A(4) and lipoxin A(4).12432935Serhan CNProstaglandins & other lipid mediatorsLipoxins and aspirin-triggered 15-epi-lipoxin biosynthesis: an update and role in anti-inflammation and pro-resolution. Prostaglandins Other Lipid Mediat. 2002 Aug; 68-69:433-55.Prostaglandins Other Lipid Mediat2002-08-01T00:00:002002Lipoxins and aspirin-triggered 15-epi-lipoxin biosynthesis: an update and role in anti-inflammation and pro-resolution.20383154Xu ZZ, Zhang L, Liu T, Park JY, Berta T, Yang R, Serhan CN, Ji RRNature medicineResolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions. 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J Intern Med. 2010 Jul; 268(1):15-24.J Intern Med2010-04-28T00:00:002010Profiling in resolving inflammatory exudates identifies novel anti-inflammatory and pro-resolving mediators and signals for termination.21206090Oh SF, Pillai PS, Recchiuti A, Yang R, Serhan CNThe Journal of clinical investigationPro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation. J Clin Invest. 2011 Feb; 121(2):569-81.J Clin Invest2011-01-04T00:00:002011Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation.21268007Schif-Zuck S, Gross N, Assi S, Rostoker R, Serhan CN, Ariel AEuropean journal of immunologySaturated-efferocytosis generates pro-resolving CD11b low macrophages: modulation by resolvins and glucocorticoids. Eur J Immunol. 2011 Feb; 41(2):366-79.Eur J Immunol2010-12-29T00:00:002010Saturated-efferocytosis generates pro-resolving CD11b low macrophages: modulation by resolvins and glucocorticoids.17496159Campbell EL, Louis NA, Tomassetti SE, Canny GO, Arita M, Serhan CN, Colgan SPFASEB journal : official publication of the Federation of American Societies for Experimental BiologyResolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution. FASEB J. 2007 Oct; 21(12):3162-70.FASEB J2007-05-11T00:00:002007Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution.22566890Ariel A, Serhan CNFrontiers in immunologyNew Lives Given by Cell Death: Macrophage Differentiation Following Their Encounter with Apoptotic Leukocytes during the Resolution of Inflammation. Front Immunol. 2012; 3:4.Front Immunol2012-01-31T00:00:002012New Lives Given by Cell Death: Macrophage Differentiation Following Their Encounter with Apoptotic Leukocytes during the Resolution of Inflammation.3593345Badr KF, Serhan CN, Nicolaou KC, Samuelsson BBiochemical and biophysical research communicationsThe action of lipoxin-A on glomerular microcirculatory dynamics in the rat. Biochem Biophys Res Commun. 1987 May 29; 145(1):408-14.Biochem Biophys Res Commun1987-05-29T00:00:001987The action of lipoxin-A on glomerular microcirculatory dynamics in the rat.3630737Dahlén SE, Raud J, Serhan CN, Björk J, Samuelsson BActa physiologica ScandinavicaBiological activities of lipoxin A include lung strip contraction and dilation of arterioles in vivo. Acta Physiol Scand. 1987 Aug; 130(4):643-7.Acta Physiol Scand1987-08-01T00:00:001987Biological activities of lipoxin A include lung strip contraction and dilation of arterioles in vivo.8551217Maddox JF, Serhan CNThe Journal of experimental medicineLipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction. J Exp Med. 1996 Jan 01; 183(1):137-46.J Exp Med1996-01-01T00:00:001996Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction.6279647Serhan CN, Fridovich J, Goetzl EJ, Dunham PB, Weissmann GThe Journal of biological chemistryLeukotriene B4 and phosphatidic acid are calcium ionophores. Studies employing arsenazo III in liposomes. J Biol Chem. 1982 May 10; 257(9):4746-52.J Biol Chem1982-05-10T00:00:001982Leukotriene B4 and phosphatidic acid are calcium ionophores. 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J Clin Invest. 1994 Feb; 93(2):499-508.J Clin Invest1994-02-01T00:00:001994Remodeling of neutrophil phospholipids with 15(S)-hydroxyeicosatetraenoic acid inhibits leukotriene B4-induced neutrophil migration across endothelium.8389617Fiore S, Romano M, Reardon EM, Serhan CNBloodInduction of functional lipoxin A4 receptors in HL-60 cells. Blood. 1993 Jun 15; 81(12):3395-403.Blood1993-06-15T00:00:001993Induction of functional lipoxin A4 receptors in HL-60 cells.19890019Gleissman H, Yang R, Martinod K, Lindskog M, Serhan CN, Johnsen JI, Kogner PFASEB journal : official publication of the Federation of American Societies for Experimental BiologyDocosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates. 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J Nutrigenet Nutrigenomics. 2011; 4(1):12-24.J Nutrigenet Nutrigenomics2011-04-07T00:00:002011Nutrigenetic disruption of inflammation-resolution homeostasis and atherogenesis.21711247Fredman G, Serhan CNThe Biochemical journalSpecialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution. Biochem J. 2011 Jul 15; 437(2):185-97.Biochem J2011-07-15T00:00:002011Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution.22711890Ramon S, Gao F, Serhan CN, Phipps RPJournal of immunology (Baltimore, Md. : 1950)Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells. J Immunol. 2012 Jul 15; 189(2):1036-42.J Immunol2012-06-18T00:00:002012Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells.22841830Giera M, Ioan-Facsinay A, Toes R, Gao F, Dalli J, Deelder AM, Serhan CN, Mayboroda OABiochimica et biophysica actaLipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC-MS/MS. Biochim Biophys Acta. 2012 Nov; 1821(11):1415-24.Biochim Biophys Acta2012-07-24T00:00:002012Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC-MS/MS.2992247Samuelsson B, Hammarström S, Hamberg M, Serhan CNAdvances in prostaglandin, thromboxane, and leukotriene researchStructural determination of leukotrienes and lipoxins. Adv Prostaglandin Thromboxane Leukot Res. 1985; 14:45-71.Adv Prostaglandin Thromboxane Leukot Res1985-01-01T00:00:001985Structural determination of leukotrienes and lipoxins.23510485Winkler JW, Uddin J, Serhan CN, Petasis NAOrganic lettersStereocontrolled total synthesis of the potent anti-inflammatory and pro-resolving lipid mediator resolvin D3 and its aspirin-triggered 17R-epimer. Org Lett. 2013 Apr 05; 15(7):1424-7.Org Lett2013-03-19T00:00:002013Stereocontrolled total synthesis of the potent anti-inflammatory and pro-resolving lipid mediator resolvin D3 and its aspirin-triggered 17R-epimer.21232258Brady HR, Papayianni A, Serhan CNTrends in cardiovascular medicinePotential vascular roles for lipoxins in the "stop programs" of host defense and inflammation. Trends Cardiovasc Med. 1995 Sep-Oct; 5(5):186-92.Trends Cardiovasc Med1995-09-01T00:00:001995Potential vascular roles for lipoxins in the "stop programs" of host defense and inflammation.Authorship 102876622538616Chiang N, Fredman G, Bäckhed F, Oh SF, Vickery T, Schmidt BA, Serhan CNNatureInfection regulates pro-resolving mediators that lower antibiotic requirements. Nature. 2012 Apr 25; 484(7395):524-8.Nature2012-04-25T00:00:002012Infection regulates pro-resolving mediators that lower antibiotic requirements.22542947Bazan NG, Eady TN, Khoutorova L, Atkins KD, Hong S, Lu Y, Zhang C, Jun B, Obenaus A, Fredman G, Zhu M, Winkler JW, Petasis NA, Serhan CN, Belayev LExperimental neurologyNovel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke. Exp Neurol. 2012 Jul; 236(1):122-30.Exp Neurol2012-04-19T00:00:002012Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke.2995494Ramstedt U, Ng J, Wigzell H, Serhan CN, Samuelsson BJournal of immunology (Baltimore, Md. : 1950)Action of novel eicosanoids lipoxin A and B on human natural killer cell cytotoxicity: effects on intracellular cAMP and target cell binding. J Immunol. 1985 Nov; 135(5):3434-8.J Immunol1985-11-01T00:00:001985Action of novel eicosanoids lipoxin A and B on human natural killer cell cytotoxicity: effects on intracellular cAMP and target cell binding.18411340Machado FS, Esper L, Dias A, Madan R, Gu Y, Hildeman D, Serhan CN, Karp CL, Aliberti JThe Journal of experimental medicineNative and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6. J Exp Med. 2008 May 12; 205(5):1077-86.J Exp Med2008-04-14T00:00:002008Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6.18480426Dona M, Fredman G, Schwab JM, Chiang N, Arita M, Goodarzi A, Cheng G, von Andrian UH, Serhan CNBloodResolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets. Blood. 2008 Aug 01; 112(3):848-55.Blood2008-05-14T00:00:002008Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets.18997012Malawista SE, de Boisfleury Chevance A, van Damme J, Serhan CNProceedings of the National Academy of Sciences of the United States of AmericaTonic inhibition of chemotaxis in human plasma. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17949-54.Proc Natl Acad Sci U S A2008-11-07T00:00:002008Tonic inhibition of chemotaxis in human plasma.19422383Spite M, Summers L, Porter TF, Srivastava S, Bhatnagar A, Serhan CNBritish journal of pharmacologyResolvin D1 controls inflammation initiated by glutathione-lipid conjugates formed during oxidative stress. Br J Pharmacol. 2009 Oct; 158(4):1062-73.Br J Pharmacol2009-05-05T00:00:002009Resolvin D1 controls inflammation initiated by glutathione-lipid conjugates formed during oxidative stress.20956612Recchiuti A, Krishnamoorthy S, Fredman G, Chiang N, Serhan CNFASEB journal : official publication of the Federation of American Societies for Experimental BiologyMicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits. FASEB J. 2011 Feb; 25(2):544-60.FASEB J2010-10-18T00:00:002010MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits.Authorship 10932664Authorship 1093902530204204Tungen JE, Aursnes M, Ramon S, Colas RA, Serhan CN, Olberg DE, Nuruddin S, Willoch F, Hansen TVOrganic & biomolecular chemistrySynthesis of protectin D1 analogs: novel pro-resolution and radiotracer agents. Org Biomol Chem. 2018 09 19; 16(36):6818-6823.Org Biomol Chem2018-09-19T00:00:002018Synthesis of protectin D1 analogs: novel pro-resolution and radiotracer agents.30242013Diaz LA, Altman NH, Khan WN, Serhan CN, Adkins BInfection and immunityCorrection for Diaz et al., "Specialized Proresolving Mediators Rescue Infant Mice from Lethal Citrobacter rodentium Infection and Promote Immunity against Reinfection". Infect Immun. 2018 10; 86(10).Infect Immun2018-09-21T00:00:002018Correction for Diaz et al., "Specialized Proresolving Mediators Rescue Infant Mice from Lethal Citrobacter rodentium Infection and Promote Immunity against Reinfection".21712098Oh SF, Vickery TW, Serhan CNBiochimica et biophysica actaChiral lipidomics of E-series resolvins: aspirin and the biosynthesis of novel mediators. Biochim Biophys Acta. 2011 Nov; 1811(11):737-47.Biochim Biophys Acta2011-06-16T00:00:002011Chiral lipidomics of E-series resolvins: aspirin and the biosynthesis of novel mediators.2949567Serhan CN, Hamberg M, Ramstedt U, Samuelsson BAdvances in prostaglandin, thromboxane, and leukotriene researchLipoxins: stereochemistry, biosynthesis and biological activities. Adv Prostaglandin Thromboxane Leukot Res. 1986; 16:83-97.Adv Prostaglandin Thromboxane Leukot Res1986-01-01T00:00:001986Lipoxins: stereochemistry, biosynthesis and biological activities.22499990Norling LV, Dalli J, Flower RJ, Serhan CN, Perretti MArteriosclerosis, thrombosis, and vascular biologyResolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler Thromb Vasc Biol. 2012 Aug; 32(8):1970-8.Arterioscler Thromb Vasc Biol2012-04-12T00:00:002012Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions.3048058Serhan CN, Samuelsson BAdvances in experimental medicine and biologyLipoxins: a new series of eicosanoids (biosynthesis, stereochemistry, and biological activities). Adv Exp Med Biol. 1988; 229:1-14.Adv Exp Med Biol1988-01-01T00:00:001988Lipoxins: a new series of eicosanoids (biosynthesis, stereochemistry, and biological activities).Authorship 1096288930279513Saban DR, Hodges RR, Mathew R, Reyes NJ, Yu C, Kaye R, Swift W, Botten N, Serhan CN, Dartt DAMucosal immunologyResolvin D1 treatment on goblet cell mucin and immune responses in the chronic allergic eye disease (AED) model. Mucosal Immunol. 2019 01; 12(1):145-153.Mucosal Immunol2018-10-02T00:00:002018Resolvin D1 treatment on goblet cell mucin and immune responses in the chronic allergic eye disease (AED) model.8158907Brady HR, Papayianni A, Serhan CNKidney international. SupplementLeukocyte adhesion promotes biosynthesis of lipoxygenase products by transcellular routes. Kidney Int Suppl. 1994 Feb; 45:S90-7.Kidney Int Suppl1994-02-01T00:00:001994Leukocyte adhesion promotes biosynthesis of lipoxygenase products by transcellular routes.15626453Serhan CNPharmacology & therapeuticsNovel omega -- 3-derived local mediators in anti-inflammation and resolution. Pharmacol Ther. 2005 Jan; 105(1):7-21.Pharmacol Ther2005-01-01T00:00:002005Novel omega -- 3-derived local mediators in anti-inflammation and resolution.16799203Chiang N, Serhan CNMethods in molecular biology (Clifton, N.J.)Cell-cell interaction in the transcellular biosynthesis of novel omega-3-derived lipid mediators. Methods Mol Biol. 2006; 341:227-50.Methods Mol Biol2006-01-01T00:00:002006Cell-cell interaction in the transcellular biosynthesis of novel omega-3-derived lipid mediators.17435267Chiang N, Serhan CNComprehensive therapyNew mechanism for an old drug: aspirin triggers anti-inflammatory lipid mediators with gender implications. Compr Ther. 2006; 32(3):150-7.Compr Ther2006-01-01T00:00:002006New mechanism for an old drug: aspirin triggers anti-inflammatory lipid mediators with gender implications.17625069Levy BD, Lukacs NW, Berlin AA, Schmidt B, Guilford WJ, Serhan CN, Parkinson JFFASEB journal : official publication of the Federation of American Societies for Experimental BiologyLipoxin A4 stable analogs reduce allergic airway responses via mechanisms distinct from CysLT1 receptor antagonism. FASEB J. 2007 Dec; 21(14):3877-84.FASEB J2007-07-11T00:00:002007Lipoxin A4 stable analogs reduce allergic airway responses via mechanisms distinct from CysLT1 receptor antagonism.7873189Serhan CNAmerican journal of respiratory cell and molecular biologyLeukocyte transmigration, chemotaxis, and oxygenated derivatives of arachidonic acid: when is chirality important? Am J Respir Cell Mol Biol. 1995 Mar; 12(3):251-3.Am J Respir Cell Mol Biol1995-03-01T00:00:001995Leukocyte transmigration, chemotaxis, and oxygenated derivatives of arachidonic acid: when is chirality important?3421155Dahlén SE, Franzén L, Raud J, Serhan CN, Westlund P, Wikström E, Björck T, Matsuda H, Webber SE, Veale CAAdvances in experimental medicine and biologyActions of lipoxin A4 and related compounds in smooth muscle preparations and on the microcirculation in vivo. Adv Exp Med Biol. 1988; 229:107-30.Adv Exp Med Biol1988-01-01T00:00:001988Actions of lipoxin A4 and related compounds in smooth muscle preparations and on the microcirculation in vivo.7586318Datta YH, Romano M, Jacobson BC, Golan DE, Serhan CN, Ewenstein BMCirculationPeptido-leukotrienes are potent agonists of von Willebrand factor secretion and P-selectin surface expression in human umbilical vein endothelial cells. Circulation. 1995 Dec 01; 92(11):3304-11.Circulation1995-12-01T00:00:001995Peptido-leukotrienes are potent agonists of von Willebrand factor secretion and P-selectin surface expression in human umbilical vein endothelial cells.30355784Serhan CN, de la Rosa X, Jouvene CCJournal of immunology (Baltimore, Md. : 1950)Cutting Edge: Human Vagus Produces Specialized Proresolving Mediators of Inflammation with Electrical Stimulation Reducing Proinflammatory Eicosanoids. J Immunol. 2018 12 01; 201(11):3161-3165.J Immunol2018-10-24T00:00:002018Cutting Edge: Human Vagus Produces Specialized Proresolving Mediators of Inflammation with Electrical Stimulation Reducing Proinflammatory Eicosanoids.Authorship 11088821Authorship 126164121357260Dartt DA, Hodges RR, Li D, Shatos MA, Lashkari K, Serhan CNJournal of immunology (Baltimore, Md. : 1950)Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. J Immunol. 2011 Apr 01; 186(7):4455-66.J Immunol2011-02-28T00:00:002011Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation.22802419Rogerio AP, Haworth O, Croze R, Oh SF, Uddin M, Carlo T, Pfeffer MA, Priluck R, Serhan CN, Levy BDJournal of immunology (Baltimore, Md. : 1950)Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses. J Immunol. 2012 Aug 15; 189(4):1983-91.J Immunol2012-07-16T00:00:002012Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses.3593338Palmblad J, Gyllenhammar H, Ringertz B, Serhan CN, Samuelsson B, Nicolaou KCBiochemical and biophysical research communicationsThe effects of lipoxin A and lipoxin B on functional responses of human granulocytes. Biochem Biophys Res Commun. 1987 May 29; 145(1):168-75.Biochem Biophys Res Commun1987-05-29T00:00:001987The effects of lipoxin A and lipoxin B on functional responses of human granulocytes.3922792Lundberg U, Serhan CN, Samuelsson BFEBS lettersAppearance of an arachidonic acid 15-lipoxygenase pathway upon differentiation of the human promyelocytic cell-line HL-60. FEBS Lett. 1985 Jun 03; 185(1):14-8.FEBS Lett1985-06-03T00:00:001985Appearance of an arachidonic acid 15-lipoxygenase pathway upon differentiation of the human promyelocytic cell-line HL-60.6814433Serhan CN, Broekman MJ, Korchak HM, Marcus AJ, Weissmann GBiochemical and biophysical research communicationsEndogenous phospholipid metabolism in stimulated neutrophils differential activation by FMLP and PMA. Biochem Biophys Res Commun. 1982 Aug; 107(3):951-8.Biochem Biophys Res Commun1982-08-01T00:00:001982Endogenous phospholipid metabolism in stimulated neutrophils differential activation by FMLP and PMA.7578068Serhan CN, Maddox JF, Petasis NA, Akritopoulou-Zanze I, Papayianni A, Brady HR, Colgan SP, Madara JLBiochemistryDesign of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils. Biochemistry. 1995 Nov 07; 34(44):14609-15.Biochemistry1995-11-07T00:00:001995Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils.7810593Simchowitz L, Fiore S, Serhan CNThe American journal of physiologyCarrier-mediated transport of lipoxin A4 in human neutrophils. Am J Physiol. 1994 Dec; 267(6 Pt 1):C1525-34.Am J Physiol1994-12-01T00:00:001994Carrier-mediated transport of lipoxin A4 in human neutrophils.Authorship 11106361630404812Matte A, Recchiuti A, Federti E, Koehl B, Mintz T, El Nemer W, Tharaux PL, Brousse V, Andolfo I, Lamolinara A, Weinberg O, Siciliano A, Norris PC, Riley IR, Iolascon A, Serhan CN, Brugnara C, De Franceschi LBloodResolution of sickle cell disease-associated inflammation and tissue damage with 17R-resolvin D1. Blood. 2019 01 17; 133(3):252-265.Blood2018-11-07T00:00:002018Resolution of sickle cell disease-associated inflammation and tissue damage with 17R-resolvin D1.11034610Serhan CN, Clish CB, Brannon J, Colgan SP, Chiang N, Gronert KThe Journal of experimental medicineNovel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. 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Francis Professor of MedicineAuthorship 1215722MRS25MatthewSpiteMatthew R Spite, Ph.D.42.33510370000000-71.1061649000000073539Spite, MatthewAssociate Professor of Anaesthesia11611selected publications28.79610.002327631311research areas19.88590.00842943110coauthor of556.71964.724560similar toDF45DevonFlahertyDevon Flaherty, M.D.42.33510370000000-71.1061649000000065007Flaherty, DevonAssistant Professor of AnaesthesiaAuthorship 1362022CW48CarmelitaWallaceCarmelita Wallace, M.D.42.33510370000000-71.1061649000000049685Wallace, CarmelitaInstructor in AnaesthesiaAuthorship 1328221NC8NanChiangNan Chiang, Ph.D.42.33510370000000-71.1061649000000023659Chiang, NanAssistant Professor of AnaesthesiaAuthorship 11617692131205032Panigrahy D, Gartung A, Yang J, Yang H, Gilligan MM, Sulciner ML, Bhasin SS, Bielenberg DR, Chang J, Schmidt BA, Piwowarski J, Fishbein A, Soler-Ferran D, Sparks MA, Staffa SJ, Sukhatme V, Hammock BD, Kieran MW, Huang S, Bhasin M, Serhan CN, Sukhatme VPThe Journal of clinical investigationPreoperative stimulation of resolution and inflammation blockade eradicates micrometastases. 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Blood. 2019 10 24; 134(17):1458-1468.Blood2019-10-24T00:00:002019Resolvin D4 attenuates the severity of pathological thrombosis in mice.31300512Rao Z, Pace S, Jordan PM, Bilancia R, Troisi F, Börner F, Andreas N, Kamradt T, Menche D, Rossi A, Serhan CN, Gerstmeier J, Werz OJournal of immunology (Baltimore, Md. : 1950)Vacuolar (H+)-ATPase Critically Regulates Specialized Proresolving Mediator Pathways in Human M2-like Monocyte-Derived Macrophages and Has a Crucial Role in Resolution of Inflammation. 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J Clin Invest. 2019 11 01; 129(11):4553-4555.J Clin Invest2019-11-01T00:00:002019A tribute to Gerald Weissmann (1930-2019).31611555Krashia P, Cordella A, Nobili A, La Barbera L, Federici M, Leuti A, Campanelli F, Natale G, Marino G, Calabrese V, Vedele F, Ghiglieri V, Picconi B, Di Lazzaro G, Schirinzi T, Sancesario G, Casadei N, Riess O, Bernardini S, Pisani A, Calabresi P, Viscomi MT, Serhan CN, Chiurchiù V, D'Amelio M, Mercuri NBNature communicationsAuthor Correction: Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson's disease. Nat Commun. 2019 Oct 14; 10(1):4725.Nat Commun2019-10-14T00:00:002019Author Correction: Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson's disease.Authorship 120451Authorship 1201376531657786Chiang N, Libreros S, Norris PC, de la Rosa X, Serhan CNThe Journal of clinical investigationMaresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions. 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Sci Adv. 2019 10; 5(10):eaax4895.Sci Adv2019-10-23T00:00:002019Resolution metabolomes activated by hypoxic environment.true1Instructor in AnaesthesiaInstructor in Anaesthesiatrue1Mallinckrodt Professor of MedicineMallinckrodt Professor of Medicinetrue1Associate Professor of AnaesthesiaAssociate Professor of Anaesthesiatrue1Professor of OphthalmologyProfessor of Ophthalmologytrue1Simon Gelman Professor of AnaesthesiaSimon Gelman Professor of AnaesthesiaAuthorship 12067188Authorship 120700318Authorship 12084171931780628Kooij G, Troletti CD, Leuti A, Norris PC, Riley I, Albanese M, Ruggieri S, Libreros S, van der Pol SMA, van Het Hof B, Schell Y, Guerrera G, Buttari F, Mercuri NB, Centonze D, Gasperini C, Battistini L, de Vries HE, Serhan CN, Chiurchiù VHaematologicaSpecialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction. Haematologica. 2020 08; 105(8):2056-2070.Haematologica2019-11-28T00:00:002019Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction.31763448Zhou Y, Lei J, Xie Q, Wu L, Jin S, Guo B, Wang X, Yan G, Zhang Q, Zhao H, Zhang J, Zhang X, Wang J, Gu J, Liu X, Ye D, Miao H, Serhan CN, Li YScience advancesFibrinogen-like protein 2 controls sepsis catabasis by interacting with resolvin Dp5. Sci Adv. 2019 11; 5(11):eaax0629.Sci Adv2019-11-13T00:00:002019Fibrinogen-like protein 2 controls sepsis catabasis by interacting with resolvin Dp5.31774939Tungen JE, Gerstmann L, Vik A, De Matteis R, Colas RA, Dalli J, Chiang N, Serhan CN, Kalesse M, Hansen TVChemistry (Weinheim an der Bergstrasse, Germany)Addendum: Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1n-3?DPA. Chemistry. 2019 11 27; 25(66):15212.Chemistry2019-11-07T00:00:002019Addendum: Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1n-3?DPA.Authorship 1514134Authorship 1212565731852986Norris PC, Skulas-Ray AC, Riley I, Richter CK, Kris-Etherton PM, Jensen GL, Serhan CN, Maddipati KRScientific reportsAuthor Correction: Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation. Sci Rep. 2019 Dec 19; 9(1):19816.Sci Rep2019-12-19T00:00:002019Author Correction: Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation.Authorship 150703Authorship 1203315Authorship 1217464831918915Tourki B, Kain V, Pullen AB, Norris PC, Patel N, Arora P, Leroy X, Serhan CN, Halade GVMolecular metabolismLack of resolution sensor drives age-related cardiometabolic and cardiorenal defects and impedes inflammation-resolution in heart failure. Mol Metab. 2020 01; 31:138-149.Mol Metab2019-11-16T00:00:002019Lack of resolution sensor drives age-related cardiometabolic and cardiorenal defects and impedes inflammation-resolution in heart failure.Authorship 129737Authorship 1327002Authorship 1734461Authorship 1682986Authorship 1723001Authorship 1764365Authorship 1694729Authorship 181396532295449Pullen AB, Kain V, Serhan CN, Halade GVJournal of the American Heart AssociationMolecular and Cellular Differences in Cardiac Repair of Male and Female Mice. J Am Heart Assoc. 2020 04 21; 9(8):e015672.J Am Heart Assoc2020-04-16T00:00:002020Molecular and Cellular Differences in Cardiac Repair of Male and Female Mice.Authorship 12425483Authorship 12453748Authorship 1245287832361084Yang M, Lippestad M, Hodges RR, Fjærvoll HK, Fjærvoll KA, Bair JA, Utheim TP, Serhan CN, Dartt DAThe ocular surfaceRvE1 uses the LTB4 receptor BLT1 to increase [Ca2+]i and stimulate mucin secretion in cultured rat and human conjunctival goblet cells. Ocul Surf. 2020 07; 18(3):470-482.Ocul Surf2020-04-30T00:00:002020RvE1 uses the LTB4 receptor BLT1 to increase [Ca2+]i and stimulate mucin secretion in cultured rat and human conjunctival goblet cells.32385712Panigrahy D, Gilligan MM, Huang S, Gartung A, Cortés-Puch I, Sime PJ, Phipps RP, Serhan CN, Hammock BDCancer metastasis reviewsInflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19? Cancer Metastasis Rev. 2020 06; 39(2):337-340.Cancer Metastasis Rev2020-06-01T00:00:002020Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?Authorship 191021Authorship 1826603Authorship 2081582Authorship 12554156Authorship 12571504Authorship 1256298532561135Yang M, Bair JA, Hodges RR, Serhan CN, Dartt DAThe American journal of pathologyResolvin E1 Reduces Leukotriene B4-Induced Intracellular Calcium Increase and Mucin Secretion in Rat Conjunctival Goblet Cells. Am J Pathol. 2020 09; 190(9):1823-1832.Am J Pathol2020-06-16T00:00:002020Resolvin E1 Reduces Leukotriene B4-Induced Intracellular Calcium Increase and Mucin Secretion in Rat Conjunctival Goblet Cells.32543720Tourki B, Kain V, Shaikh SR, Leroy X, Serhan CN, Halade GVFASEB journal : official publication of the Federation of American Societies for Experimental BiologyDeficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity. FASEB J. 2020 08; 34(8):10560-10573.FASEB J2020-06-16T00:00:002020Deficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity.32510663Olsen MV, Lyngstadaas AV, Bair JA, Hodges RR, Utheim TP, Serhan CN, Dartt DAJournal of cellular physiologyMaresin 1, a specialized proresolving mediator, stimulates intracellular [Ca2+ ] and secretion in conjunctival goblet cells. J Cell Physiol. 2021 01; 236(1):340-353.J Cell Physiol2020-06-08T00:00:002020Maresin 1, a specialized proresolving mediator, stimulates intracellular [Ca2+ ] and secretion in conjunctival goblet cells.Authorship 1404271Authorship 1321479Authorship 1449862Authorship 1488021Authorship 1767521Authorship 12825292Authorship 1281629132885825Chiang N, Serhan CNEssays in biochemistrySpecialized pro-resolving mediator network: an update on production and actions. Essays Biochem. 2020 09 23; 64(3):443-462.Essays Biochem2020-09-23T00:00:002020Specialized pro-resolving mediator network: an update on production and actions.32873427Serhan CN, Gupta SK, Perretti M, Godson C, Brennan E, Li Y, Soehnlein O, Shimizu T, Werz O, Chiurchiù V, Azzi A, Dubourdeau M, Gupta SS, Schopohl P, Hoch M, Gjorgevikj D, Khan FM, Brauer D, Tripathi A, Cesnulevicius K, Lescheid D, Schultz M, Särndahl E, Repsilber D, Kruse R, Sala A, Haeggström JZ, Levy BD, Filep JG, Wolkenhauer OMolecular aspects of medicineWITHDRAWN: The Atlas of Inflammation Resolution (AIR). Mol Aspects Med. 2020 08 29; 100893.Mol Aspects Med2020-08-29T00:00:002020WITHDRAWN: The Atlas of Inflammation Resolution (AIR).Authorship 2056343Authorship 2238361Authorship 12862381Authorship 1286375332891711Fishbein A, Hammock BD, Serhan CN, Panigrahy DPharmacology & therapeuticsCarcinogenesis: Failure of resolution of inflammation? Pharmacol Ther. 2021 02; 218:107670.Pharmacol Ther2020-09-03T00:00:002020Carcinogenesis: Failure of resolution of inflammation?32893032Serhan CN, Gupta SK, Perretti M, Godson C, Brennan E, Li Y, Soehnlein O, Shimizu T, Werz O, Chiurchiù V, Azzi A, Dubourdeau M, Gupta SS, Schopohl P, Hoch M, Gjorgevikj D, Khan FM, Brauer D, Tripathi A, Cesnulevicius K, Lescheid D, Schultz M, Särndahl E, Repsilber D, Kruse R, Sala A, Haeggström JZ, Levy BD, Filep JG, Wolkenhauer OMolecular aspects of medicineThe Atlas of Inflammation Resolution (AIR). Mol Aspects Med. 2020 08; 74:100894.Mol Aspects Med2020-09-03T00:00:002020The Atlas of Inflammation Resolution (AIR).Authorship 1289329332956495Andreakos E, Papadaki M, Serhan CNAllergyDexamethasone, pro-resolving lipid mediators and resolution of inflammation in COVID-19. Allergy. 2021 03; 76(3):626-628.Allergy2021-03-01T00:00:002021Dexamethasone, pro-resolving lipid mediators and resolution of inflammation in COVID-19.true1Assistant Professor of AnaesthesiaAssistant Professor of AnaesthesiaAuthorship 1921099Authorship 129762315Authorship 12978087Authorship 12973756Authorship 1297377633047359Ganesan R, Henkels KM, Shah K, De La Rosa X, Libreros S, Cheemarla NR, Serhan CN, Gomez-Cambronero JFASEB journal : official publication of the Federation of American Societies for Experimental BiologyD-series Resolvins activate Phospholipase D in phagocytes during inflammation and resolution. FASEB J. 2020 12; 34(12):15888-15906.FASEB J2020-10-12T00:00:002020D-series Resolvins activate Phospholipase D in phagocytes during inflammation and resolution.33038416Zirpoli H, Sosunov SA, Niatsetskaya ZV, Mayurasakorn K, Manual Kollareth DJ, Serhan CN, Ten VS, Deckelbaum RJExperimental neurologyNPD1 rapidly targets mitochondria-mediated apoptosis after acute injection protecting brain against ischemic injury. Exp Neurol. 2021 01; 335:113495.Exp Neurol2020-10-08T00:00:002020NPD1 rapidly targets mitochondria-mediated apoptosis after acute injection protecting brain against ischemic injury.33038830Manual Kollareth DJ, Deckelbaum RJ, Liu Z, Ramakrishnan R, Jouvene C, Serhan CN, Ten VS, Zirpoli HProstaglandins, leukotrienes, and essential fatty acidsAcute injection of a DHA triglyceride emulsion after hypoxic-ischemic brain injury in mice increases both DHA and EPA levels in blood and brain?. Prostaglandins Leukot Essent Fatty Acids. 2020 11; 162:102176.Prostaglandins Leukot Essent Fatty Acids2020-09-25T00:00:002020Acute injection of a DHA triglyceride emulsion after hypoxic-ischemic brain injury in mice increases both DHA and EPA levels in blood and brain?.33053344Jordan PM, Gerstmeier J, Pace S, Bilancia R, Rao Z, Börner F, Miek L, Gutiérrez-Gutiérrez Ó, Arakandy V, Rossi A, Ialenti A, González-Estévez C, Löffler B, Tuchscherr L, Serhan CN, Werz OCell reportsStaphylococcus aureus-Derived a-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution. Cell Rep. 2020 10 13; 33(2):108247.Cell Rep2020-10-13T00:00:002020Staphylococcus aureus-Derived a-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution.Authorship 1464961Authorship 1900351Authorship 1308622533273748Sønderskov J, Tungen JE, Palmas F, Dalli J, Serhan CN, Stenstrøm Y, Hansen TVTetrahedron lettersStereoselective synthesis of MaR2n-3 DPA. Tetrahedron Lett. 2020 Feb 13; 61(7).Tetrahedron Lett2019-12-09T00:00:002019Stereoselective synthesis of MaR2n-3 DPA.23747022Serhan CN, Chiang NCurrent opinion in pharmacologyResolution phase lipid mediators of inflammation: agonists of resolution. Curr Opin Pharmacol. 2013 Aug; 13(4):632-40.Curr Opin Pharmacol2013-06-06T00:00:002013Resolution phase lipid mediators of inflammation: agonists of resolution.Authorship 1554048Authorship 2148179Authorship 1321581633427310Ríos JD, Hughes CK, Lally J, Wienandt N, Esquivel C, Serhan CN, Weitzel EKThe LaryngoscopeNeuroprotectin D1 Attenuates Blast Overpressure Induced Reactive Microglial Cells in the Cochlea. Laryngoscope. 2021 06; 131(6):E2018-E2025.Laryngoscope2021-01-11T00:00:002021Neuroprotectin D1 Attenuates Blast Overpressure Induced Reactive Microglial Cells in the Cochlea.Authorship 1325325433534565Reinertsen AF, Primdahl KG, Shay AE, Serhan CN, Hansen TV, Aursnes MThe Journal of organic chemistryStereoselective Synthesis and Structural Confirmation of the Specialized Pro-Resolving Mediator Resolvin E4. J Org Chem. 2021 02 19; 86(4):3535-3545.J Org Chem2021-02-03T00:00:002021Stereoselective Synthesis and Structural Confirmation of the Specialized Pro-Resolving Mediator Resolvin E4.Authorship 1327823233551236Simopoulos AP, Serhan CN, Bazinet RPMolecular aspects of medicineThe need for precision nutrition, genetic variation and resolution in Covid-19 patients. Mol Aspects Med. 2021 02; 77:100943.Mol Aspects Med2021-01-28T00:00:002021The need for precision nutrition, genetic variation and resolution in Covid-19 patients.Authorship 13351407Authorship 1335417633649212Chiang N, de la Rosa X, Libreros S, Pan H, Dreyfuss JM, Serhan CNProceedings of the National Academy of Sciences of the United States of AmericaCysteinyl-specialized proresolving mediators link resolution of infectious inflammation and tissue regeneration via TRAF3 activation. Proc Natl Acad Sci U S A. 2021 03 09; 118(10).Proc Natl Acad Sci U S A2021-03-09T00:00:002021Cysteinyl-specialized proresolving mediators link resolution of infectious inflammation and tissue regeneration via TRAF3 activation.33643307Libreros S, Shay AE, Nshimiyimana R, Fichtner D, Martin MJ, Wourms N, Serhan CNFrontiers in immunologyA New E-Series Resolvin: RvE4 Stereochemistry and Function in Efferocytosis of Inflammation-Resolution. Front Immunol. 2020; 11:631319.Front Immunol2021-02-10T00:00:002021A New E-Series Resolvin: RvE4 Stereochemistry and Function in Efferocytosis of Inflammation-Resolution.Authorship 13373578Authorship 1338367533687402Nesman JI, Chen O, Luo X, Ji RR, Serhan CN, Hansen TVOrganic & biomolecular chemistryA new synthetic protectin D1 analog 3-oxa-PD1n-3 DPA reduces neuropathic pain and chronic itch in mice. Org Biomol Chem. 2021 03 28; 19(12):2744-2752.Org Biomol Chem2021-03-09T00:00:002021A new synthetic protectin D1 analog 3-oxa-PD1n-3 DPA reduces neuropathic pain and chronic itch in mice.33689792Sansbury BE, Li X, Wong B, Riley CO, Shay AE, Nshimiyimana R, Petasis NA, Serhan CN, Spite MThe American journal of pathologyPCTR1 Enhances Repair and Bacterial Clearance in Skin Wounds. Am J Pathol. 2021 06; 191(6):1049-1063.Am J Pathol2021-03-06T00:00:002021PCTR1 Enhances Repair and Bacterial Clearance in Skin Wounds.Authorship 16298572026-03-31SERHAN, CHARLES NICHOLAS2021-04-01Evaluating Resolution Mechanisms for Infectious InflammationR35GM139430Principal InvestigatorAuthorship 1504426Authorship 1418564Authorship 1349817333915177Panigrahy D, Gilligan MM, Serhan CN, Kashfi KPharmacology & therapeuticsResolution of inflammation: An organizing principle in biology and medicine. Pharmacol Ther. 2021 11; 227:107879.Pharmacol Ther2021-04-27T00:00:002021Resolution of inflammation: An organizing principle in biology and medicine.Authorship 149654Authorship 1354285633968020Lyngstadaas AV, Olsen MV, Bair JA, Hodges RR, Utheim TP, Serhan CN, Dartt DAFrontiers in immunologyPro-Resolving Mediator Annexin A1 Regulates Intracellular Ca2+ and Mucin Secretion in Cultured Goblet Cells Suggesting a New Use in Inflammatory Conjunctival Diseases. Front Immunol. 2021; 12:618653.Front Immunol2021-04-22T00:00:002021Pro-Resolving Mediator Annexin A1 Regulates Intracellular Ca2+ and Mucin Secretion in Cultured Goblet Cells Suggesting a New Use in Inflammatory Conjunctival Diseases.ron314RobertNshimiyimanaRobert Nshimiyimana, Ph.D.198289Nshimiyimana, RobertInstructor in AnaesthesiaAuthorship 13602331134077725Derada Troletti C, Enzmann G, Chiurchiù V, Kamermans A, Tietz SM, Norris PC, Jahromi NH, Leuti A, van der Pol SMA, Schouten M, Serhan CN, de Vries HE, Engelhardt B, Kooij GCell reportsPro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome. Cell Rep. 2021 06 01; 35(9):109201.Cell Rep2021-06-01T00:00:002021Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome.Authorship 2541715Authorship 1802449Authorship 1831445Authorship 187976Authorship 193135Authorship 13926605Authorship 139445313134529832Alexander SP, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Abbracchio MP, Alexander W, Al-Hosaini K, Bäck M, Barnes NM, Bathgate R, Beaulieu JM, Bernstein KE, Bettler B, Birdsall NJM, Blaho V, Boulay F, Bousquet C, Bräuner-Osborne H, Burnstock G, Caló G, Castaño JP, Catt KJ, Ceruti S, Chazot P, Chiang N, Chini B, Chun J, Cianciulli A, Civelli O, Clapp LH, Couture R, Csaba Z, Dahlgren C, Dent G, Singh KD, Douglas SD, Dournaud P, Eguchi S, Escher E, Filardo EJ, Fong T, Fumagalli M, Gainetdinov RR, Gasparo M, Gerard C, Gershengorn M, Gobeil F, Goodfriend TL, Goudet C, Gregory KJ, Gundlach AL, Hamann J, Hanson J, Hauger RL, Hay DL, Heinemann A, Hollenberg MD, Holliday ND, Horiuchi M, Hoyer D, Hunyady L, Husain A, IJzerman AP, Inagami T, Jacobson KA, Jensen RT, Jockers R, Jonnalagadda D, Karnik S, Kaupmann K, Kemp J, Kennedy C, Kihara Y, Kitazawa T, Kozielewicz P, Kreienkamp HJ, Kukkonen JP, Langenhan T, Leach K, Lecca D, Lee JD, Leeman SE, Leprince J, Li XX, Williams TL, Lolait SJ, Lupp A, Macrae R, Maguire J, Mazella J, McArdle CA, Melmed S, Michel MC, Miller LJ, Mitolo V, Mouillac B, Müller CE, Murphy P, Nahon JL, Ngo T, Norel X, Nyimanu D, O'Carroll AM, Offermanns S, Panaro MA, Parmentier M, Pertwee RG, Pin JP, Prossnitz ER, Quinn M, Ramachandran R, Ray M, Reinscheid RK, Rondard P, Rovati GE, Ruzza C, Sanger GJ, Schöneberg T, Schulte G, Schulz S, Segaloff DL, Serhan CN, Stoddart LA, Sugimoto Y, Summers R, Tan VP, Thal D, Thomas WW, Timmermans PBMWM, Tirupula K, Tulipano G, Unal H, Unger T, Valant C, Vanderheyden P, Vaudry D, Vaudry H, Vilardaga JP, Walker CS, Wang JM, Ward DT, Wester HJ, Willars GB, Woodruff TM, Yao C, Ye RDBritish journal of pharmacologyTHE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. Br J Pharmacol. 2021 Oct; 178 Suppl 1:S27-S156.Br J Pharmacol2021-10-01T00:00:002021THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors.34489955Walker KH, Krishnamoorthy N, Brüggemann TR, Shay AE, Serhan CN, Levy BDFrontiers in immunologyProtectins PCTR1 and PD1 Reduce Viral Load and Lung Inflammation During Respiratory Syncytial Virus Infection in Mice. Front Immunol. 2021; 12:704427.Front Immunol2021-08-19T00:00:002021Protectins PCTR1 and PD1 Reduce Viral Load and Lung Inflammation During Respiratory Syncytial Virus Infection in Mice.Authorship 2068255Authorship 1410180634814186Chiang N, Sakuma M, Rodriguez AR, Spur BW, Irimia D, Serhan CNBloodResolvin T-series reduce neutrophil extracellular traps. Blood. 2022 02 24; 139(8):1222-1233.Blood2022-02-24T00:00:002022Resolvin T-series reduce neutrophil extracellular traps.Authorship 1512043Authorship 1421235634911767Shay AE, Nshimiyimana R, Samuelsson B, Petasis NA, Haeggström JZ, Serhan CNProceedings of the National Academy of Sciences of the United States of AmericaHuman leukocytes selectively convert 4S,5S-epoxy-resolvin to resolvin D3, resolvin D4, and a cys-resolvin isomer. Proc Natl Acad Sci U S A. 2021 12 21; 118(51).Proc Natl Acad Sci U S A2021-12-21T00:00:002021Human leukocytes selectively convert 4S,5S-epoxy-resolvin to resolvin D3, resolvin D4, and a cys-resolvin isomer.Authorship 191180335046831Troisi F, Pace S, Jordan PM, Meyer KPL, Bilancia R, Ialenti A, Borrelli F, Rossi A, Sautebin L, Serhan CN, Werz OFrontiers in pharmacologySex Hormone-Dependent Lipid Mediator Formation in Male and Female Mice During Peritonitis. Front Pharmacol. 2021; 12:818544.Front Pharmacol2022-01-03T00:00:002022Sex Hormone-Dependent Lipid Mediator Formation in Male and Female Mice During Peritonitis.35008563Yang M, Botten N, Hodges R, Bair J, Utheim TP, Serhan CN, Dartt DAInternational journal of molecular sciencesResolvin D2 and Resolvin D1 Differentially Activate Protein Kinases to Counter-Regulate Histamine-Induced [Ca2+]i Increase and Mucin Secretion in Conjunctival Goblet Cells. Int J Mol Sci. 2021 Dec 23; 23(1).Int J Mol Sci2021-12-23T00:00:002021Resolvin D2 and Resolvin D1 Differentially Activate Protein Kinases to Counter-Regulate Histamine-Induced [Ca2+]i Increase and Mucin Secretion in Conjunctival Goblet Cells.Authorship 14258356Authorship 142632810Authorship 2026104Authorship 2122584Authorship 14315621035143048Miek L, Jordan PM, Günther K, Pace S, Beyer T, Kowalak D, Hoerr V, Löffler B, Tuchscherr L, Serhan CN, Gerstmeier J, Werz OImmunologyStaphylococcus aureus controls eicosanoid and specialized pro-resolving mediator production via lipoteichoic acid. Immunology. 2022 05; 166(1):47-67.Immunology2022-03-09T00:00:002022Staphylococcus aureus controls eicosanoid and specialized pro-resolving mediator production via lipoteichoic acid.Authorship 2403302Authorship 14359125Authorship 1441344135227568Serhan CN, Libreros S, Nshimiyimana RSeminars in immunologyE-series resolvin metabolome, biosynthesis and critical role of stereochemistry of specialized pro-resolving mediators (SPMs) in inflammation-resolution: Preparing SPMs for long COVID-19, human clinical trials, and targeted precision nutrition. Semin Immunol. 2022 01; 59:101597.Semin Immunol2022-02-16T00:00:002022E-series resolvin metabolome, biosynthesis and critical role of stereochemistry of specialized pro-resolving mediators (SPMs) in inflammation-resolution: Preparing SPMs for long COVID-19, human clinical trials, and targeted precision nutrition.35190921Barksdale C, Kipper FC, Tripathy S, Subbian S, Serhan CN, Panigrahy DCancer metastasis reviewsCOVID-19 and cancer: start the resolution! Cancer Metastasis Rev. 2022 03; 41(1):1-15.Cancer Metastasis Rev2022-03-01T00:00:002022COVID-19 and cancer: start the resolution!Authorship 2798881Authorship 144536811Authorship 14469834Authorship 1448885435508275Dyall SC, Balas L, Bazan NG, Brenna JT, Chiang N, da Costa Souza F, Dalli J, Durand T, Galano JM, Lein PJ, Serhan CN, Taha AYProgress in lipid researchPolyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions. Prog Lipid Res. 2022 04; 86:101165.Prog Lipid Res2022-05-01T00:00:002022Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions.35481084Nshimiyimana R, Lam TF, Aggarwal S, Serhan CN, Petasis NARSC advancesFirst stereoselective total synthesis of 4(S),5(S)-oxido-17(S)-hydroxy-6(E),8(E),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid, the biosynthetic precursor of resolvins D3 and D4. RSC Adv. 2022 Apr 13; 12(19):11613-11618.RSC Adv2022-04-13T00:00:002022First stereoselective total synthesis of 4(S),5(S)-oxido-17(S)-hydroxy-6(E),8(E),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid, the biosynthetic precursor of resolvins D3 and D4.35428422Rakian A, Rakian R, Shay AE, Serhan CN, Van Dyke TEJournal of dental researchPeriodontal Stem Cells Synthesize Maresin Conjugate in Tissue Regeneration 3. J Dent Res. 2022 09; 101(10):1205-1213.J Dent Res2022-04-15T00:00:002022Periodontal Stem Cells Synthesize Maresin Conjugate in Tissue Regeneration 3.Authorship 2964843Authorship 3067491Authorship 312692Authorship 3421301Authorship 346531true1Assistant Professor of AnaesthesiaAssistant Professor of AnaesthesiaAuthorship 3535852Authorship 146088516Authorship 14628628Authorship 14663116Authorship 1460050435682912Olsen MV, Lyngstadaas AV, Bair JA, Hodges RR, Utheim TP, Serhan CN, Dartt DAInternational journal of molecular sciencesSignaling Pathways Used by the Specialized Pro-Resolving Mediator Maresin 2 Regulate Goblet Cell Function: Comparison with Maresin 1. Int J Mol Sci. 2022 Jun 02; 23(11).Int J Mol Sci2022-06-02T00:00:002022Signaling Pathways Used by the Specialized Pro-Resolving Mediator Maresin 2 Regulate Goblet Cell Function: Comparison with Maresin 1.35837790Bhattacharya J, Booy R, Casadevall A, Dela Cruz C, Fedson DS, Garcia JGN, Grohmann G, Hung IFN, Jacobson JR, Jennings LC, Kobzik L, Leligdowicz A, Liao JK, Martin JH, Musher DM, Serhan CN, Tashiro MPharmacology research & perspectivesA practical treatment for COVID-19 and the next pandemic. Pharmacol Res Perspect. 2022 08; 10(4):e00988.Pharmacol Res Perspect2022-08-01T00:00:002022A practical treatment for COVID-19 and the next pandemic.35850309Hamidzadeh K, Westcott J, Wourms N, Shay AE, Panigrahy A, Martin MJ, Nshimiyimana R, Serhan CNBiochemical pharmacologyA newly synthesized 17-epi-NeuroProtectin D1/17-epi-Protectin D1: Authentication and functional regulation of Inflammation-Resolution. Biochem Pharmacol. 2022 09; 203:115181.Biochem Pharmacol2022-07-16T00:00:002022A newly synthesized 17-epi-NeuroProtectin D1/17-epi-Protectin D1: Authentication and functional regulation of Inflammation-Resolution.35894061Choi MY, Cook NR, Kotler G, Serhan CN, Tatituri R, Costenbader KHClinical and experimental rheumatologyFish oil supplementation in patients with and without systemic lupus erythematosus: targeting pro-inflammatory and pro-resolving lipid mediators. Clin Exp Rheumatol. 2022 11; 40(11):2196-2197.Clin Exp Rheumatol2022-07-21T00:00:002022Fish oil supplementation in patients with and without systemic lupus erythematosus: targeting pro-inflammatory and pro-resolving lipid mediators.Authorship 4150713Authorship 14856455Authorship 14925878Authorship 15009926Authorship 15032852Authorship 1500375336267914Hopke A, Lin T, Scherer AK, Shay AE, Timmer KD, Wilson-Mifsud B, Mansour MK, Serhan CN, Irimia D, Hurley BPiScienceTranscellular biosynthesis of leukotriene B4 orchestrates neutrophil swarming to fungi. iScience. 2022 Oct 21; 25(10):105226.iScience2022-09-28T00:00:002022Transcellular biosynthesis of leukotriene B4 orchestrates neutrophil swarming to fungi.36345797Nshimiyimana R, Glynn SJ, Serhan CN, Petasis NAOrganic & biomolecular chemistryStereocontrolled total synthesis of Resolvin D4 and 17(R)-Resolvin D4. Org Biomol Chem. 2023 02 22; 21(8):1667-1673.Org Biomol Chem2023-02-22T00:00:002023Stereocontrolled total synthesis of Resolvin D4 and 17(R)-Resolvin D4.36341938Vidar Hansen T, Serhan CNBiochemical pharmacologyProtectins: Their biosynthesis, metabolism and structure-functions. Biochem Pharmacol. 2022 12; 206:115330.Biochem Pharmacol2022-10-28T00:00:002022Protectins: Their biosynthesis, metabolism and structure-functions.36175572Yang M, Fjærvoll HK, Fjærvoll KA, Wang NH, Utheim TP, Serhan CN, Dartt DAScientific reportsSex-based differences in conjunctival goblet cell responses to pro-inflammatory and pro-resolving mediators. Sci Rep. 2022 09 29; 12(1):16305.Sci Rep2022-09-29T00:00:002022Sex-based differences in conjunctival goblet cell responses to pro-inflammatory and pro-resolving mediators.36066128Botten N, Hodges RR, Bair J, Utheim TP, Serhan CN, Yang M, Dartt DAJournal of cellular physiologyResolvin D2 uses multiple Ca2+ -dependent signaling pathways to stimulate mucin secretion in rat and human conjunctival goblet cells. J Cell Physiol. 2022 10; 237(10):3816-3833.J Cell Physiol2022-09-06T00:00:002022Resolvin D2 uses multiple Ca2+ -dependent signaling pathways to stimulate mucin secretion in rat and human conjunctival goblet cells.Authorship 4427687Authorship 1504862536378290Furutani K, Chen O, McGinnis A, Wang Y, Serhan CN, Hansen TV, Ji RRPainNovel proresolving lipid mediator mimetic 3-oxa-PD1n-3 docosapentaenoic acid reduces acute and chronic itch by modulating excitatory and inhibitory synaptic transmission and astroglial secretion of lipocalin-2 in mice. Pain. 2023 06 01; 164(6):1340-1354.Pain2022-11-14T00:00:002022Novel proresolving lipid mediator mimetic 3-oxa-PD1n-3 docosapentaenoic acid reduces acute and chronic itch by modulating excitatory and inhibitory synaptic transmission and astroglial secretion of lipocalin-2 in mice.Authorship 2223136Authorship 1516059536647836Chiang N, Libreros S, Norris PC, de la Rosa X, Serhan CNThe Journal of clinical investigationMaresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions. J Clin Invest. 2023 01 17; 133(2).J Clin Invest2023-01-17T00:00:002023Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions.Authorship 15238711Authorship 15270461Authorship 1523428836813255Serhan CN, Chiang NProstaglandins & other lipid mediatorsResolvins and cysteinyl-containing pro-resolving mediators activate resolution of infectious inflammation and tissue regeneration. Prostaglandins Other Lipid Mediat. 2023 06; 166:106718.Prostaglandins Other Lipid Mediat2023-02-21T00:00:002023Resolvins and cysteinyl-containing pro-resolving mediators activate resolution of infectious inflammation and tissue regeneration.36752208Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN, Perretti MJCI insightProresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. JCI Insight. 2023 02 08; 8(3).JCI Insight2023-02-08T00:00:002023Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis.36781545Serhan CN, Sulciner MLCancer metastasis reviewsResolution medicine in cancer, infection, pain and inflammation: are we on track to address the next Pandemic? Cancer Metastasis Rev. 2023 03; 42(1):13-17.Cancer Metastasis Rev2023-03-01T00:00:002023Resolution medicine in cancer, infection, pain and inflammation: are we on track to address the next Pandemic?Authorship 1775062Authorship 2113634Authorship 49958310true1Instructor in AnaesthesiaInstructor in Anaesthesiatrue1Assistant Professor of AnaesthesiaAssistant Professor of AnaesthesiaAuthorship 15687954Authorship 15569816Authorship 15701568Authorship 15596934Authorship 15437074Authorship 15581158Authorship 1553384737487095Li W, Shepherd HM, Terada Y, Shay AE, Bery AI, Gelman AE, Lavine KJ, Serhan CN, Kreisel DProceedings of the National Academy of Sciences of the United States of AmericaResolvin D1 prevents injurious neutrophil swarming in transplanted lungs. Proc Natl Acad Sci U S A. 2023 08; 120(31):e2302938120.Proc Natl Acad Sci U S A2023-07-24T00:00:002023Resolvin D1 prevents injurious neutrophil swarming in transplanted lungs.37295018Libreros S, Nshimiyimana R, Lee B, Serhan CNBloodInfectious neutrophil deployment is regulated by resolvin D4. Blood. 2023 08 10; 142(6):589-606.Blood2023-08-10T00:00:002023Infectious neutrophil deployment is regulated by resolvin D4.37117719Harris WS, Calder PC, Mozaffarian D, Serhan CNNature foodBang and Dyerberg's omega-3 discovery turns fifty. Nat Food. 2021 May; 2(5):303-305.Nat Food2021-05-01T00:00:002021Bang and Dyerberg's omega-3 discovery turns fifty.37139907Nshimiyimana R, Libreros S, Simard M, Chiang N, Rodriguez AR, Spur BW, Haeggström JZ, Serhan CNAmerican journal of hematologyStereochemistry and functions of the new cysteinyl-resolvin, 4S,5R-RCTR1, in efferocytosis and erythrophagocytosis of human senescent erythrocytes. Am J Hematol. 2023 07; 98(7):1000-1016.Am J Hematol2023-05-04T00:00:002023Stereochemistry and functions of the new cysteinyl-resolvin, 4S,5R-RCTR1, in efferocytosis and erythrophagocytosis of human senescent erythrocytes.37423551Lyngstadaas AV, Olsen MV, Bair J, Yang M, Hodges RR, Utheim TP, Serhan CN, Dartt DAThe American journal of pathologyAnti-Inflammatory and Pro-Resolving Actions of the N-Terminal Peptides Ac2-26, Ac2-12, and Ac9-25 of Annexin A1 on Conjunctival Goblet Cell Function. Am J Pathol. 2023 11; 193(11):1817-1832.Am J Pathol2023-07-07T00:00:002023Anti-Inflammatory and Pro-Resolving Actions of the N-Terminal Peptides Ac2-26, Ac2-12, and Ac9-25 of Annexin A1 on Conjunctival Goblet Cell Function.37463914Ramirez JL, de Almeida Oliveira G, Calvo E, Dalli J, Colas RA, Serhan CN, Ribeiro JM, Barillas-Mury CNature communicationsAuthor Correction: A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae. Nat Commun. 2023 Jul 18; 14(1):4305.Nat Commun2023-07-18T00:00:002023Author Correction: A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae.37428488Nunes VS, Abrahão O, Rogério AP, Serhan CNThe journal of physical chemistry. BALX/FPR2 Activation by Stereoisomers of D1 Resolvins Elucidating with Molecular Dynamics Simulation. J Phys Chem B. 2023 07 27; 127(29):6479-6486.J Phys Chem B2023-07-10T00:00:002023ALX/FPR2 Activation by Stereoisomers of D1 Resolvins Elucidating with Molecular Dynamics Simulation.Authorship 279934437552821Brüggemann TR, Peh HY, Tavares LP, Nijmeh J, Shay AE, Rezende RM, Lanser TB, Serhan CN, Levy BDAmerican journal of respiratory cell and molecular biologyEosinophil Phenotypes Are Functionally Regulated by Resolvin D2 during Allergic Lung Inflammation. Am J Respir Cell Mol Biol. 2023 12; 69(6):666-677.Am J Respir Cell Mol Biol2023-12-01T00:00:002023Eosinophil Phenotypes Are Functionally Regulated by Resolvin D2 during Allergic Lung Inflammation.Authorship 3295786Authorship 333082Authorship 3532783Authorship 15934168Authorship 158224716Authorship 1586132837603745Rao Z, Brunner E, Giszas B, Iyer-Bierhoff A, Gerstmeier J, Börner F, Jordan PM, Pace S, Meyer KPL, Hofstetter RK, Merk D, Paulenz C, Heinzel T, Grunert PC, Stallmach A, Serhan CN, Werner M, Werz OProceedings of the National Academy of Sciences of the United States of AmericaGlucocorticoids regulate lipid mediator networks by reciprocal modulation of 15-lipoxygenase isoforms affecting inflammation resolution. Proc Natl Acad Sci U S A. 2023 08 29; 120(35):e2302070120.Proc Natl Acad Sci U S A2023-08-21T00:00:002023Glucocorticoids regulate lipid mediator networks by reciprocal modulation of 15-lipoxygenase isoforms affecting inflammation resolution.37770436Werz O, Gerstmeier J, Libreros S, De la Rosa X, Werner M, Norris PC, Chiang N, Serhan CNNature communicationsAuthor Correction: Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity. Nat Commun. 2023 Sep 28; 14(1):6056.Nat Commun2023-09-28T00:00:002023Author Correction: Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity.true1Assistant Professor of AnaesthesiaAssistant Professor of AnaesthesiaAuthorship 3819375true1Professor of Oral Medicine, Infection, and ImmunityProfessor of Oral Medicine, Infection, and Immunitytrue1Assistant Professor of AnaesthesiaAssistant Professor of AnaesthesiaAuthorship 16012248Authorship 16025421137878483Soens MA, Sesso HD, Manson JE, Fields KG, Buring JE, Lee IM, Cook NR, Kim E, Bubes V, Dushkes R, Serhan CN, Rathmell JPPainThe effect of vitamin D and omega-3 fatty acid supplementation on pain prevalence and severity in older adults: a large-scale ancillary study of the VITamin D and OmegA-3 triaL (VITAL). Pain. 2024 Mar 01; 165(3):635-643.Pain2023-10-25T00:00:002023The effect of vitamin D and omega-3 fatty acid supplementation on pain prevalence and severity in older adults: a large-scale ancillary study of the VITamin D and OmegA-3 triaL (VITAL).37888888Peh HY, Brüggemann TR, Duvall MG, Nshimiyimana R, Nijmeh J, Cinelli MA, Israel E, Serhan CN, Levy BDAllergyResolvin D2 regulates type 2 inflammatory responses and promotes resolution of mouse allergic inflammation. Allergy. 2024 Mar; 79(3):739-743.Allergy2023-10-27T00:00:002023Resolvin D2 regulates type 2 inflammatory responses and promotes resolution of mouse allergic inflammation.Authorship 1780406Authorship 1824031true1Parker B. Francis Professor of MedicineParker B. Francis Professor of MedicineAuthorship 5029983Authorship 16155864Authorship 161460713838123151Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA, Abbracchio MP, Abraham G, Agoulnik A, Alexander W, Al-Hosaini K, Bäck M, Baker JG, Barnes NM, Bathgate R, Beaulieu JM, Beck-Sickinger AG, Behrens M, Bernstein KE, Bettler B, Birdsall NJM, Blaho V, Boulay F, Bousquet C, Bräuner-Osborne H, Burnstock G, Caló G, Castaño JP, Catt KJ, Ceruti S, Chazot P, Chiang N, Chini B, Chun J, Cianciulli A, Civelli O, Clapp LH, Couture R, Cox HM, Csaba Z, Dahlgren C, Dent G, Douglas SD, Dournaud P, Eguchi S, Escher E, Filardo EJ, Fong T, Fumagalli M, Gainetdinov RR, Garelja ML, de Gasparo M, Gerard C, Gershengorn M, Gobeil F, Goodfriend TL, Goudet C, Grätz L, Gregory KJ, Gundlach AL, Hamann J, Hanson J, Hauger RL, Hay DL, Heinemann A, Herr D, Hollenberg MD, Holliday ND, Horiuchi M, Hoyer D, Hunyady L, Husain A, IJzerman AP, Inagami T, Jacobson KA, Jensen RT, Jockers R, Jonnalagadda D, Karnik S, Kaupmann K, Kemp J, Kennedy C, Kihara Y, Kitazawa T, Kozielewicz P, Kreienkamp HJ, Kukkonen JP, Langenhan T, Larhammar D, Leach K, Lecca D, Lee JD, Leeman SE, Leprince J, Li XX, Lolait SJ, Lupp A, Macrae R, Maguire J, Malfacini D, Mazella J, McArdle CA, Melmed S, Michel MC, Miller LJ, Mitolo V, Mouillac B, Müller CE, Murphy PM, Nahon JL, Ngo T, Norel X, Nyimanu D, O'Carroll AM, Offermanns S, Panaro MA, Parmentier M, Pertwee RG, Pin JP, Prossnitz ER, Quinn M, Ramachandran R, Ray M, Reinscheid RK, Rondard P, Rovati GE, Ruzza C, Sanger GJ, Schöneberg T, Schulte G, Schulz S, Segaloff DL, Serhan CN, Singh KD, Smith CM, Stoddart LA, Sugimoto Y, Summers R, Tan VP, Thal D, Thomas WW, Timmermans PBMWM, Tirupula K, Toll L, Tulipano G, Unal H, Unger T, Valant C, Vanderheyden P, Vaudry D, Vaudry H, Vilardaga JP, Walker CS, Wang JM, Ward DT, Wester HJ, Willars GB, Williams TL, Woodruff TM, Yao C, Ye RDBritish journal of pharmacologyThe Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. Br J Pharmacol. 2023 10; 180 Suppl 2:S23-S144.Br J Pharmacol2023-10-01T00:00:002023The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.38093843Reinertsen AF, Libreros S, Nshimiyimana R, Serhan CN, Hansen TVACS pharmacology & translational scienceMetabolization of Resolvin E4 by ?-Oxidation in Human Neutrophils: Synthesis and Biological Evaluation of 20-Hydroxy-Resolvin E4 (20-OH-RvE4). ACS Pharmacol Transl Sci. 2023 Dec 08; 6(12):1898-1908.ACS Pharmacol Transl Sci2023-11-20T00:00:002023Metabolization of Resolvin E4 by ?-Oxidation in Human Neutrophils: Synthesis and Biological Evaluation of 20-Hydroxy-Resolvin E4 (20-OH-RvE4).Authorship 5111204Authorship 5431436Authorship 1620831238216693Fredman G, Serhan CNNature reviews. CardiologySpecialized pro-resolving mediators in vascular inflammation and atherosclerotic cardiovascular disease. Nat Rev Cardiol. 2024 Jan 12.Nat Rev Cardiol2024-01-12T00:00:002024Specialized pro-resolving mediators in vascular inflammation and atherosclerotic cardiovascular disease.Authorship 1626275238294489Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR, Schmidt B, Dalli J, Greene ER, Gus-Brautbar Y, Piwowarski J, Mammoto T, Zurakowski D, Perretti M, Sukhatme VP, Kaipainen A, Kieran MW, Huang S, Panigrahy DThe Journal of experimental medicineAddendum: Resolvins suppress tumor growth and enhance cancer therapy. J Exp Med. 2024 Mar 04; 221(3).J Exp Med2024-01-31T00:00:002024Addendum: Resolvins suppress tumor growth and enhance cancer therapy.Authorship 5469215Authorship 5574872Authorship 594471Authorship 2527973Authorship 3069806Authorship 3813174Authorship 4808431Authorship 2520196Authorship 2998977Authorship 6477737Authorship 6462481Authorship 66194910Authorship 6593888Authorship 6469113Authorship 6667895Authorship 6646197Authorship 646750723584892Koltsida O, Karamnov S, Pyrillou K, Vickery T, Chairakaki AD, Tamvakopoulos C, Sideras P, Serhan CN, Andreakos EEMBO molecular medicineToll-like receptor 7 stimulates production of specialized pro-resolving lipid mediators and promotes resolution of airway inflammation. EMBO Mol Med. 2013 May; 5(5):762-75.EMBO Mol Med2013-04-15T00:00:002013Toll-like receptor 7 stimulates production of specialized pro-resolving lipid mediators and promotes resolution of airway inflammation.23736886Dalli J, Colas RA, Serhan CNScientific reportsNovel n-3 immunoresolvents: structures and actions. Sci Rep. 2013; 3:1940.Sci Rep2013-01-01T00:00:002013Novel n-3 immunoresolvents: structures and actions.23504711Dalli J, Zhu M, Vlasenko NA, Deng B, Haeggström JZ, Petasis NA, Serhan CNFASEB journal : official publication of the Federation of American Societies for Experimental BiologyThe novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype. FASEB J. 2013 Jul; 27(7):2573-83.FASEB J2013-03-15T00:00:002013The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype.23349501Neuhofer A, Zeyda M, Mascher D, Itariu BK, Murano I, Leitner L, Hochbrugger EE, Fraisl P, Cinti S, Serhan CN, Stulnig TMDiabetesImpaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation. Diabetes. 2013 Jun; 62(6):1945-56.Diabetes2013-01-24T00:00:002013Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation.23407709Miyahara T, Runge S, Chatterjee A, Chen M, Mottola G, Fitzgerald JM, Serhan CN, Conte MSFASEB journal : official publication of the Federation of American Societies for Experimental BiologyD-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury. FASEB J. 2013 Jun; 27(6):2220-32.FASEB J2013-02-13T00:00:002013D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury.23364264Clària J, Nguyen BT, Madenci AL, Ozaki CK, Serhan CNAmerican journal of physiology. Cell physiologyDiversity of lipid mediators in human adipose tissue depots. Am J Physiol Cell Physiol. 2013 Jun 15; 304(12):C1141-9.Am J Physiol Cell Physiol2013-01-30T00:00:002013Diversity of lipid mediators in human adipose tissue depots.Authorship 5093006Authorship 5639416Authorship 67635511Authorship 676365723956430Divanovic S, Dalli J, Jorge-Nebert LF, Flick LM, Gálvez-Peralta M, Boespflug ND, Stankiewicz TE, Fitzgerald JM, Somarathna M, Karp CL, Serhan CN, Nebert DWJournal of immunology (Baltimore, Md. : 1950)Contributions of the three CYP1 monooxygenases to pro-inflammatory and inflammation-resolution lipid mediator pathways. J Immunol. 2013 Sep 15; 191(6):3347-57.J Immunol2013-08-16T00:00:002013Contributions of the three CYP1 monooxygenases to pro-inflammatory and inflammation-resolution lipid mediator pathways.23864609Mustafa M, Zarrough A, Bolstad AI, Lygre H, Mustafa K, Hasturk H, Serhan C, Kantarci A, Van Dyke TEAmerican journal of physiology. Cell physiologyResolvin D1 protects periodontal ligament. Am J Physiol Cell Physiol. 2013 Sep 15; 305(6):C673-9.Am J Physiol Cell Physiol2013-07-17T00:00:002013Resolvin D1 protects periodontal ligament.Authorship 6790756Authorship 679211723686636Xu ZZ, Liu XJ, Berta T, Park CK, Lü N, Serhan CN, Ji RRAnnals of neurologyNeuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma. Ann Neurol. 2013 Sep; 74(3):490-5.Ann Neurol2013-09-04T00:00:002013Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma.Authorship 153758Authorship 681014823919613Orr SK, Palumbo S, Bosetti F, Mount HT, Kang JX, Greenwood CE, Ma DW, Serhan CN, Bazinet RPJournal of neurochemistryUnesterified docosahexaenoic acid is protective in neuroinflammation. J Neurochem. 2013 Nov; 127(3):378-93.J Neurochem2013-08-28T00:00:002013Unesterified docosahexaenoic acid is protective in neuroinflammation.Authorship 1624464Authorship 2773091Authorship 2784662Authorship 2916024Authorship 311623124238341Li Y, Dalli J, Chiang N, Baron RM, Quintana C, Serhan CNImmunityPlasticity of leukocytic exudates in resolving acute inflammation is regulated by MicroRNA and proresolving mediators. Immunity. 2013 Nov 14; 39(5):885-98.Immunity2013-11-14T00:00:002013Plasticity of leukocytic exudates in resolving acute inflammation is regulated by MicroRNA and proresolving mediators.Authorship 6940576Authorship 225901Authorship 2280991Authorship 3663112Authorship 369671Authorship 1943201Authorship 2063835Authorship 2020861Authorship 2534351Authorship 703507324239568Spite M, Clària J, Serhan CNCell metabolismResolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases. Cell Metab. 2014 Jan 07; 19(1):21-36.Cell Metab2013-11-14T00:00:002013Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases.Authorship 230602122690022Petasis NA, Yang R, Winkler JW, Zhu M, Uddin J, Bazan NG, Serhan CNTetrahedron lettersStereocontrolled total synthesis of neuroprotectin D1 / protectin D1 and its aspirin-triggered stereoisomer. Tetrahedron Lett. 2012 Apr 04; 53(14):1695-1698.Tetrahedron Lett2012-01-14T00:00:002012Stereocontrolled total synthesis of neuroprotectin D1 / protectin D1 and its aspirin-triggered stereoisomer.Authorship 2572479Authorship 2579813Authorship 267035Authorship 2685397Authorship 2733791Authorship 667972Authorship 289446Authorship 2907681Authorship 3239112Authorship 7169492Authorship 720775324166736Ramon S, Bancos S, Serhan CN, Phipps RPEuropean journal of immunologyLipoxin A4 modulates adaptive immunity by decreasing memory B-cell responses via an ALX/FPR2-dependent mechanism. Eur J Immunol. 2014 Feb; 44(2):357-69.Eur J Immunol2014-02-01T00:00:002014Lipoxin A4 modulates adaptive immunity by decreasing memory B-cell responses via an ALX/FPR2-dependent mechanism.24313723Levy BD, Serhan CNAnnual review of physiologyResolution of acute inflammation in the lung. Annu Rev Physiol. 2014; 76:467-92.Annu Rev Physiol2013-12-02T00:00:002013Resolution of acute inflammation in the lung.Authorship 2244686Authorship 2339472Authorship 2364831Authorship 3293392Authorship 2632754Authorship 896151Authorship 1676791Authorship 1683166Authorship 7265803Authorship 726048724656045Buckley CD, Gilroy DW, Serhan CNImmunityProresolving lipid mediators and mechanisms in the resolution of acute inflammation. Immunity. 2014 Mar 20; 40(3):315-27.Immunity2014-03-20T00:00:002014Proresolving lipid mediators and mechanisms in the resolution of acute inflammation.24576195Aursnes M, Tungen JE, Vik A, Colas R, Cheng CY, Dalli J, Serhan CN, Hansen TVJournal of natural productsTotal synthesis of the lipid mediator PD1n-3 DPA: configurational assignments and anti-inflammatory and pro-resolving actions. J Nat Prod. 2014 Apr 25; 77(4):910-6.J Nat Prod2014-02-27T00:00:002014Total synthesis of the lipid mediator PD1n-3 DPA: configurational assignments and anti-inflammatory and pro-resolving actions.Authorship 3088232Authorship 3452666Authorship 1776592Authorship 1817734Authorship 1835267Authorship 7322151Authorship 732084524899309Serhan CNNaturePro-resolving lipid mediators are leads for resolution physiology. Nature. 2014 Jun 05; 510(7503):92-101.Nature2014-06-05T00:00:002014Pro-resolving lipid mediators are leads for resolution physiology.24863066Mirakaj V, Dalli J, Granja T, Rosenberger P, Serhan CNThe Journal of experimental medicineVagus nerve controls resolution and pro-resolving mediators of inflammation. J Exp Med. 2014 Jun 02; 211(6):1037-48.J Exp Med2014-05-26T00:00:002014Vagus nerve controls resolution and pro-resolving mediators of inflammation.Authorship 2830189Authorship 165449224528237Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann MBritish journal of pharmacologyThe Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol. 2013 Dec; 170(8):1449-58.Br J Pharmacol2013-12-01T00:00:002013The Concise Guide to PHARMACOLOGY 2013/14: overview.24890726McCauley LK, Dalli J, Koh AJ, Chiang N, Serhan CNJournal of immunology (Baltimore, Md. : 1950)Cutting edge: Parathyroid hormone facilitates macrophage efferocytosis in bone marrow via proresolving mediators resolvin D1 and resolvin D2. J Immunol. 2014 Jul 01; 193(1):26-9.J Immunol2014-06-02T00:00:002014Cutting edge: Parathyroid hormone facilitates macrophage efferocytosis in bone marrow via proresolving mediators resolvin D1 and resolvin D2.24696140Colas RA, Shinohara M, Dalli J, Chiang N, Serhan CNAmerican journal of physiology. Cell physiologyIdentification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue. Am J Physiol Cell Physiol. 2014 Jul 01; 307(1):C39-54.Am J Physiol Cell Physiol2014-04-02T00:00:002014Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue.Authorship 7373165Authorship 7398525Authorship 2580203Authorship 3572199Authorship 3626946Authorship 3772427Authorship 3138484Authorship 3393951Authorship 342193Authorship 2747235Authorship 3153083Authorship 4490389Authorship 362741Authorship 398760725146982Hua J, Jin Y, Chen Y, Inomata T, Lee H, Chauhan SK, Petasis NA, Serhan CN, Dana RInvestigative ophthalmology & visual scienceThe resolvin D1 analogue controls maturation of dendritic cells and suppresses alloimmunity in corneal transplantation. Invest Ophthalmol Vis Sci. 2014 Aug 21; 55(9):5944-51.Invest Ophthalmol Vis Sci2014-08-21T00:00:002014The resolvin D1 analogue controls maturation of dendritic cells and suppresses alloimmunity in corneal transplantation.Authorship 490907125139562Serhan CN, Dalli J, Colas RA, Winkler JW, Chiang NBiochimica et biophysica actaProtectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. Biochim Biophys Acta. 2015 Apr; 1851(4):397-413.Biochim Biophys Acta2014-08-17T00:00:002014Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome.Authorship 7535186Authorship 752801725036362Deng B, Wang CW, Arnardottir HH, Li Y, Cheng CY, Dalli J, Serhan CNPloS oneMaresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages. PLoS One. 2014; 9(7):e102362.PLoS One2014-07-18T00:00:002014Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages.24588652Bäck M, Powell WS, Dahlén SE, Drazen JM, Evans JF, Serhan CN, Shimizu T, Yokomizo T, Rovati GEBritish journal of pharmacologyUpdate on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7. Br J Pharmacol. 2014 Aug; 171(15):3551-74.Br J Pharmacol2014-07-12T00:00:002014Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7.Authorship 5087234Authorship 5437243Authorship 3633302Authorship 7598435Authorship 761533825172497Tang H, Liu Y, Yan C, Petasis NA, Serhan CN, Gao HJournal of immunology (Baltimore, Md. : 1950)Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl ester, in C5a-dependent IgG immune complex-induced inflammation and lung injury. J Immunol. 2014 Oct 01; 193(7):3769-78.J Immunol2014-08-29T00:00:002014Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl ester, in C5a-dependent IgG immune complex-induced inflammation and lung injury.Authorship 761830525217168Arnardottir HH, Dalli J, Colas RA, Shinohara M, Serhan CNJournal of immunology (Baltimore, Md. : 1950)Aging delays resolution of acute inflammation in mice: reprogramming the host response with novel nano-proresolving medicines. J Immunol. 2014 Oct 15; 193(8):4235-44.J Immunol2014-09-12T00:00:002014Aging delays resolution of acute inflammation in mice: reprogramming the host response with novel nano-proresolving medicines.Authorship 407748Authorship 76581815Authorship 7654137Authorship 7654205Authorship 7653415Authorship 766021325329995Frediani JK, Jones DP, Tukvadze N, Uppal K, Sanikidze E, Kipiani M, Tran VT, Hebbar G, Walker DI, Kempker RR, Kurani SS, Colas RA, Dalli J, Tangpricha V, Serhan CN, Blumberg HM, Ziegler TRPloS onePlasma metabolomics in human pulmonary tuberculosis disease: a pilot study. PLoS One. 2014; 9(10):e108854.PLoS One2014-10-15T00:00:002014Plasma metabolomics in human pulmonary tuberculosis disease: a pilot study.25342442Dalli J, Colas RA, Serhan CNScientific reportsCORRIGENDUM: Novel n-3 Immunoresolvents: Structures and Actions. Sci Rep. 2014; 4:6726.Sci Rep2014-10-24T00:00:002014CORRIGENDUM: Novel n-3 Immunoresolvents: Structures and Actions.25247845Tungen JE, Aursnes M, Vik A, Ramon S, Colas RA, Dalli J, Serhan CN, Hansen TVJournal of natural productsSynthesis and anti-inflammatory and pro-resolving activities of 22-OH-PD1, a monohydroxylated metabolite of protectin D1. J Nat Prod. 2014 Oct 24; 77(10):2241-7.J Nat Prod2014-09-23T00:00:002014Synthesis and anti-inflammatory and pro-resolving activities of 22-OH-PD1, a monohydroxylated metabolite of protectin D1.25250709Tungen JE, Aursnes M, Dalli J, Arnardottir H, Serhan CN, Hansen TVChemistry (Weinheim an der Bergstrasse, Germany)Total Synthesis of the Anti-inflammatory and Pro-resolving Lipid Mediator MaR1n-3 DPA Utilizing an sp(3) -sp(3) Negishi Cross-Coupling Reaction. Chemistry. 2014 Nov 3; 20(45):14537.Chemistry2014-09-24T00:00:002014Total Synthesis of the Anti-inflammatory and Pro-resolving Lipid Mediator MaR1n-3 DPA Utilizing an sp(3) -sp(3) Negishi Cross-Coupling Reaction.25225129Tungen JE, Aursnes M, Dalli J, Arnardottir H, Serhan CN, Hansen TVChemistry (Weinheim an der Bergstrasse, Germany)Total synthesis of the anti-inflammatory and pro-resolving lipid mediator MaR1n-3 DPA utilizing an sp(3) -sp(3) Negishi cross-coupling reaction. Chemistry. 2014 Nov 03; 20(45):14575-8.Chemistry2014-09-15T00:00:002014Total synthesis of the anti-inflammatory and pro-resolving lipid mediator MaR1n-3 DPA utilizing an sp(3) -sp(3) Negishi cross-coupling reaction.25324525Dalli J, Chiang N, Serhan CNProceedings of the National Academy of Sciences of the United States of AmericaIdentification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):E4753-61.Proc Natl Acad Sci U S A2014-10-16T00:00:002014Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection.25359497Serhan CN, Chiang N, Dalli J, Levy BDCold Spring Harbor perspectives in biologyLipid mediators in the resolution of inflammation. Cold Spring Harb Perspect Biol. 2014 Oct 30; 7(2):a016311.Cold Spring Harb Perspect Biol2014-10-30T00:00:002014Lipid mediators in the resolution of inflammation.25217660Shinohara M, Kibi M, Riley IR, Chiang N, Dalli J, Kraft BD, Piantadosi CA, Choi AM, Serhan CNAmerican journal of physiology. Lung cellular and molecular physiologyCell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1. Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15; 307(10):L746-57.Am J Physiol Lung Cell Mol Physiol2014-09-12T00:00:002014Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1.Authorship 7679163Authorship 2239187Authorship 7707029Authorship 771690925369934Abdulnour RE, Dalli J, Colby JK, Krishnamoorthy N, Timmons JY, Tan SH, Colas RA, Petasis NA, Serhan CN, Levy BDProceedings of the National Academy of Sciences of the United States of AmericaMaresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16526-31.Proc Natl Acad Sci U S A2014-11-04T00:00:002014Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective.Authorship 4982281Authorship 4437501Authorship 4484847Authorship 7732786Authorship 773687825392529Ramon S, Baker SF, Sahler JM, Kim N, Feldsott EA, Serhan CN, Martínez-Sobrido L, Topham DJ, Phipps RPJournal of immunology (Baltimore, Md. : 1950)The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant? J Immunol. 2014 Dec 15; 193(12):6031-40.J Immunol2014-11-12T00:00:002014The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant?25273880Hong S, Tian H, Lu Y, Laborde JM, Muhale FA, Wang Q, Alapure BV, Serhan CN, Bazan NGAmerican journal of physiology. Cell physiologyNeuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes. Am J Physiol Cell Physiol. 2014 Dec 01; 307(11):C1058-67.Am J Physiol Cell Physiol2014-10-01T00:00:002014Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes.Authorship 4823621Authorship 775156725389003Van Dyke TE, Hasturk H, Kantarci A, Freire MO, Nguyen D, Dalli J, Serhan CNJournal of dental researchProresolving nanomedicines activate bone regeneration in periodontitis. J Dent Res. 2015 Jan; 94(1):148-56.J Dent Res2014-11-11T00:00:002014Proresolving nanomedicines activate bone regeneration in periodontitis.Authorship 4867984Authorship 513495125568926Dalli J, Kraft BD, Colas RA, Shinohara M, Fredenburgh LE, Hess DR, Chiang N, Welty-Wolf K, Choi AM, Piantadosi CA, Serhan CNAmerican journal of respiratory cell and molecular biologyThe Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide. Am J Respir Cell Mol Biol. 2015 Sep; 53(3):314-25.Am J Respir Cell Mol Biol2015-09-01T00:00:002015The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide.Authorship 557172Authorship 543048625539814Krishnamoorthy N, Burkett PR, Dalli J, Abdulnour RE, Colas R, Ramon S, Phipps RP, Petasis NA, Kuchroo VK, Serhan CN, Levy BDJournal of immunology (Baltimore, Md. : 1950)Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation. J Immunol. 2015 Feb 01; 194(3):863-7.J Immunol2014-12-24T00:00:002014Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation.Authorship 5456612Authorship 5606423Authorship 3097032Authorship 3117747Authorship 3203674Authorship 5133625Authorship 5448013Authorship 566200825713027Dalli J, Ramon S, Norris PC, Colas RA, Serhan CNFASEB journal : official publication of the Federation of American Societies for Experimental BiologyNovel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways. FASEB J. 2015 May; 29(5):2120-36.FASEB J2015-02-20T00:00:002015Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways.Authorship 751705Authorship 939942Authorship 3979127Authorship 4223984Authorship 3984802Authorship 4244621Authorship 4653492Authorship 4290812Authorship 3355695Authorship 4582793Authorship 4795223Authorship 4853764Authorship 4921072Authorship 5205682Authorship 2707477Authorship 5457055Authorship 5681143Authorship 5709583Authorship 5721861Authorship 567106Authorship 5006434Authorship 5038032Authorship 4011609Authorship 2284277Authorship 176257Authorship 2303713Authorship 1710168Authorship 1737777Authorship 923425Authorship 2455653Authorship 9794914Authorship 4813181Authorship 4976612Authorship 5112141Authorship 5325806Authorship 5499892Authorship 5548175Authorship 2408341Authorship 87006Authorship 2328151Authorship 2806111Authorship 2062863Authorship 2314994Authorship 1999482Authorship 3511681Authorship 2318171Authorship 3748919Authorship 4020854Authorship 24195310Authorship 2962056Authorship 33391Authorship 33572711Authorship 349134Authorship 3267091Authorship 307368Authorship 219827Authorship 4377335Authorship 2948002Authorship 3365631Authorship 4175662Authorship 4875831Authorship 5105421Authorship 3392781Authorship 2099553Authorship 2141943Authorship 3899801Authorship 2069267Authorship 5480974Authorship 556928625960577Shelnut EL, Nikas SP, Finnegan DF, Chiang N, Serhan CN, Makriyannis ATetrahedron lettersDesign and synthesis of novel prostaglandin E2 ethanolamide and glycerol ester probes for the putative prostamide receptor(s). Tetrahedron Lett. 2015 Mar 11; 56(11):1411-1415.Tetrahedron Lett2015-03-11T00:00:002015Design and synthesis of novel prostaglandin E2 ethanolamide and glycerol ester probes for the putative prostamide receptor(s).Authorship 776064Authorship 2675144Authorship 2912936Authorship 2930793Authorship 3071747Authorship 3130451Authorship 3251161Authorship 3610614Authorship 4273581Authorship 4490806Authorship 2727601Authorship 4537272Authorship 2316501Authorship 25749315Authorship 2818551Authorship 2994091Authorship 3221774Authorship 3543722Authorship 356841Authorship 2858966Authorship 3956214Authorship 3995701Authorship 4102181Authorship 4226901Authorship 4363252Authorship 4480292Authorship 4810191Authorship 5280044Authorship 276107225857211Serhan CN, Chiang N, Dalli JSeminars in immunologyThe resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution. Semin Immunol. 2015 May; 27(3):200-15.Semin Immunol2015-04-07T00:00:002015The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution.25701254Finnegan DF, Shelnut EL, Nikas SP, Chiang N, Serhan CN, Makriyannis ABioorganic & medicinal chemistry lettersNovel tail and head group prostamide probes. Bioorg Med Chem Lett. 2015 Mar 15; 25(6):1228-31.Bioorg Med Chem Lett2015-02-04T00:00:002015Novel tail and head group prostamide probes.25770181Orr SK, Colas RA, Dalli J, Chiang N, Serhan CNAmerican journal of physiology. Lung cellular and molecular physiologyProresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent. Am J Physiol Lung Cell Mol Physiol. 2015 May 01; 308(9):L904-11.Am J Physiol Lung Cell Mol Physiol2015-03-13T00:00:002015Proresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent.Authorship 4586224Authorship 2493868Authorship 4643748Authorship 2791265Authorship 2367386Authorship 3404497Authorship 3429357Authorship 4297411Authorship 44424316Authorship 4939701Authorship 5131581Authorship 5514631Authorship 7884525Authorship 78725112Authorship 790039153Authorship 7987125Authorship 8001231Authorship 80291110Authorship 802095524530025Wang X, Zhu M, Hjorth E, Cortés-Toro V, Eyjolfsdottir H, Graff C, Nennesmo I, Palmblad J, Eriksdotter M, Sambamurti K, Fitzgerald JM, Serhan CN, Granholm AC, Schultzberg MAlzheimer's & dementia : the journal of the Alzheimer's AssociationResolution of inflammation is altered in Alzheimer's disease. Alzheimers Dement. 2015 Jan; 11(1):40-50.e1-2.Alzheimers Dement2014-02-12T00:00:002014Resolution of inflammation is altered in Alzheimer's disease.Authorship 2586306Authorship 2709351Authorship 2886384Authorship 3075351Authorship 3143735Authorship 326663Authorship 3417858Authorship 2917836Authorship 3786845Authorship 4348801Authorship 4372786Authorship 4383237Authorship 4820484Authorship 4906621Authorship 5184554Authorship 5413652Authorship 3662655Authorship 433052Authorship 4612012Authorship 466821Authorship 8131276Authorship 813015626100162Ramirez JL, de Almeida Oliveira G, Calvo E, Dalli J, Colas RA, Serhan CN, Ribeiro JM, Barillas-Mury CNature communicationsA mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae. Nat Commun. 2015 Jun 23; 6:7403.Nat Commun2015-06-23T00:00:002015A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae.25870158Kain V, Ingle KA, Colas RA, Dalli J, Prabhu SD, Serhan CN, Joshi M, Halade GVJournal of molecular and cellular cardiologyResolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function. J Mol Cell Cardiol. 2015 Jul; 84:24-35.J Mol Cell Cardiol2015-04-11T00:00:002015Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function.Authorship 8148251026052006Börgeson E, Johnson AM, Lee YS, Till A, Syed GH, Ali-Shah ST, Guiry PJ, Dalli J, Colas RA, Serhan CN, Sharma K, Godson CCell metabolismLipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease. Cell Metab. 2015 Jul 07; 22(1):125-37.Cell Metab2015-06-04T00:00:002015Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease.Authorship 2882333Authorship 2883956Authorship 2887332Authorship 31539417Authorship 347742226195725Chiang N, Dalli J, Colas RA, Serhan CNThe Journal of experimental medicineIdentification of resolvin D2 receptor mediating resolution of infections and organ protection. J Exp Med. 2015 Jul 27; 212(8):1203-17.J Exp Med2015-07-20T00:00:002015Identification of resolvin D2 receptor mediating resolution of infections and organ protection.Authorship 8208074Authorship 8212931Authorship 452563Authorship 8247691Authorship 4693426Authorship 4776255Authorship 83190211Authorship 5169124Authorship 534748226236990Dalli J, Chiang N, Serhan CNNature medicineElucidation of novel 13-series resolvins that increase with atorvastatin and clear infections. Nat Med. 2015 Sep; 21(9):1071-5.Nat Med2015-08-03T00:00:002015Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections.Authorship 8359903Authorship 395264526488221Orr SK, Butler KL, Hayden D, Tompkins RG, Serhan CN, Irimia DCritical care medicineGene Expression of Proresolving Lipid Mediator Pathways Is Associated With Clinical Outcomes in Trauma Patients. Crit Care Med. 2015 Dec; 43(12):2642-50.Crit Care Med2015-12-01T00:00:002015Gene Expression of Proresolving Lipid Mediator Pathways Is Associated With Clinical Outcomes in Trauma Patients.Authorship 841256626301452Croasdell A, Thatcher TH, Kottmann RM, Colas RA, Dalli J, Serhan CN, Sime PJ, Phipps RPAmerican journal of physiology. Lung cellular and molecular physiologyResolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages. Am J Physiol Lung Cell Mol Physiol. 2015 Oct 15; 309(8):L888-901.Am J Physiol Lung Cell Mol Physiol2015-08-21T00:00:002015Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages.Authorship 415913Authorship 4209001Authorship 4866384Authorship 5011586Authorship 5072183Authorship 8478765Authorship 848487426468975Hsiao HM, Thatcher TH, Colas RA, Serhan CN, Phipps RP, Sime PJThe American journal of pathologyResolvin D1 Reduces Emphysema and Chronic Inflammation. Am J Pathol. 2015 Dec; 185(12):3189-201.Am J Pathol2015-10-24T00:00:002015Resolvin D1 Reduces Emphysema and Chronic Inflammation.Authorship 5181631Authorship 4329642Authorship 851981626580578Aursnes M, Tungen JE, Colas RA, Vlasakov I, Dalli J, Serhan CN, Hansen TVJournal of natural productsSynthesis of the 16S,17S-Epoxyprotectin Intermediate in the Biosynthesis of Protectins by Human Macrophages. J Nat Prod. 2015 Dec 24; 78(12):2924-31.J Nat Prod2015-11-18T00:00:002015Synthesis of the 16S,17S-Epoxyprotectin Intermediate in the Biosynthesis of Protectins by Human Macrophages.Authorship 447424326667839Wang CW, Colas RA, Dalli J, Arnardottir HH, Nguyen D, Hasturk H, Chiang N, Van Dyke TE, Serhan CNInfection and immunityMaresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes. Infect Immun. 2015 Dec 14; 84(3):658-65.Infect Immun2015-12-14T00:00:002015Maresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes.26743932Winkler JW, Orr SK, Dalli J, Cheng CY, Sanger JM, Chiang N, Petasis NA, Serhan CNScientific reportsResolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance. Sci Rep. 2016 Jan 08; 6:18972.Sci Rep2016-01-08T00:00:002016Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance.Authorship 456395Authorship 8565638Authorship 856517926607175Cianci E, Recchiuti A, Trubiani O, Diomede F, Marchisio M, Miscia S, Colas RA, Dalli J, Serhan CN, Romano MStem cells translational medicineHuman Periodontal Stem Cells Release Specialized Proresolving Mediators and Carry Immunomodulatory and Prohealing Properties Regulated by Lipoxins. Stem Cells Transl Med. 2016 Jan; 5(1):20-32.Stem Cells Transl Med2015-11-25T00:00:002015Human Periodontal Stem Cells Release Specialized Proresolving Mediators and Carry Immunomodulatory and Prohealing Properties Regulated by Lipoxins.Authorship 72582326881986Dalli J, Sanger JM, Rodriguez AR, Chiang N, Spur BW, Serhan CNPloS oneIdentification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3. PLoS One. 2016; 11(2):e0149319.PLoS One2016-02-16T00:00:002016Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3.Authorship 8676716Authorship 8706179Authorship 92958Authorship 750341Authorship 958212Authorship 3051625Authorship 3064891Authorship 31235810Authorship 3376234Authorship 3518384Authorship 8726138Authorship 872791826878209Ramon S, Dalli J, Sanger JM, Winkler JW, Aursnes M, Tungen JE, Hansen TV, Serhan CNThe American journal of pathologyThe Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation. Am J Pathol. 2016 Apr; 186(4):962-73.Am J Pathol2016-02-13T00:00:002016The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation.26588184Berrueta L, Muskaj I, Olenich S, Butler T, Badger GJ, Colas RA, Spite M, Serhan CN, Langevin HMJournal of cellular physiologyStretching Impacts Inflammation Resolution in Connective Tissue. J Cell Physiol. 2016 Jul; 231(7):1621-7.J Cell Physiol2015-12-10T00:00:002015Stretching Impacts Inflammation Resolution in Connective Tissue.Authorship 3534582Authorship 874705726650044Zhu M, Wang X, Hjorth E, Colas RA, Schroeder L, Granholm AC, Serhan CN, Schultzberg MMolecular neurobiologyPro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aß42 Phagocytosis. Mol Neurobiol. 2016 May; 53(4):2733-49.Mol Neurobiol2015-12-09T00:00:002015Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aß42 Phagocytosis.Authorship 878459426462421Arnardottir H, Orr SK, Dalli J, Serhan CNMucosal immunologyHuman milk proresolving mediators stimulate resolution of acute inflammation. Mucosal Immunol. 2016 05; 9(3):757-766.Mucosal Immunol2015-10-14T00:00:002015Human milk proresolving mediators stimulate resolution of acute inflammation.27121596Elajami TK, Colas RA, Dalli J, Chiang N, Serhan CN, Welty FKFASEB journal : official publication of the Federation of American Societies for Experimental BiologySpecialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling. FASEB J. 2016 08; 30(8):2792-801.FASEB J2016-04-27T00:00:002016Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling.27171898Colby JK, Abdulnour RE, Sham HP, Dalli J, Colas RA, Winkler JW, Hellmann J, Wong B, Cui Y, El-Chemaly S, Petasis NA, Spite M, Serhan CN, Levy BDThe American journal of pathologyResolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia. Am J Pathol. 2016 07; 186(7):1801-1813.Am J Pathol2016-05-10T00:00:002016Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia.Authorship 4710121Authorship 4840728Authorship 498723127158677Norling LV, Headland SE, Dalli J, Arnardottir HH, Haworth O, Jones HR, Irimia D, Serhan CN, Perretti MJCI insightProresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. JCI Insight. 2016 Apr 21; 1(5):e85922.JCI Insight2016-04-21T00:00:002016Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis.Authorship 5416606Authorship 884912227052783Shinohara M, Serhan CNJournal of atherosclerosis and thrombosisNovel Endogenous Proresolving Molecules:Essential Fatty Acid-Derived and Gaseous Mediators in the Resolution of Inflammation. J Atheroscler Thromb. 2016 Jun 01; 23(6):655-64.J Atheroscler Thromb2016-04-06T00:00:002016Novel Endogenous Proresolving Molecules:Essential Fatty Acid-Derived and Gaseous Mediators in the Resolution of Inflammation.Authorship 959456Authorship 563617227347562Liu F, Haeger CM, Dieffenbach PB, Sicard D, Chrobak I, Coronata AM, Suárez Velandia MM, Vitali S, Colas RA, Norris PC, Marinkovic A, Liu X, Ma J, Rose CD, Lee SJ, Comhair SA, Erzurum SC, McDonald JD, Serhan CN, Walsh SR, Tschumperlin DJ, Fredenburgh LEJCI insightDistal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension. JCI Insight. 2016 Jun 02; 1(8).JCI Insight2016-06-02T00:00:002016Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension.Authorship 5672379Authorship 8885622Authorship 88943720Authorship 8894381327169401Ferguson LR, De Caterina R, Görman U, Allayee H, Kohlmeier M, Prasad C, Choi MS, Curi R, de Luis DA, Gil Á, Kang JX, Martin RL, Milagro FI, Nicoletti CF, Nonino CB, Ordovas JM, Parslow VR, Portillo MP, Santos JL, Serhan CN, Simopoulos AP, Velázquez-Arellano A, Zulet MA, Martinez JAJournal of nutrigenetics and nutrigenomicsGuide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 - Fields of Precision Nutrition. J Nutrigenet Nutrigenomics. 2016; 9(1):12-27.J Nutrigenet Nutrigenomics2016-05-12T00:00:002016Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 - Fields of Precision Nutrition.27337457Dalli J, Serhan CMicrobiology spectrumMacrophage Proresolving Mediators-the When and Where. Microbiol Spectr. 2016 06; 4(3).Microbiol Spectr2016-06-01T00:00:002016Macrophage Proresolving Mediators-the When and Where.2Assistant Professor1Associate Professor0Full Professor4InstructorAuthorship 866768Authorship 596577Authorship 8962285Authorship 4974516Authorship 556716Authorship 6403714Authorship 9057868Authorship 86687726647716Abdulnour RE, Sham HP, Douda DN, Colas RA, Dalli J, Bai Y, Ai X, Serhan CN, Levy BDMucosal immunologyAspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation. Mucosal Immunol. 2016 09; 9(5):1278-87.Mucosal Immunol2015-12-09T00:00:002015Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation.Authorship 5005775Authorship 908804727559094Chiurchiù V, Leuti A, Dalli J, Jacobsson A, Battistini L, Maccarrone M, Serhan CNScience translational medicineProresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses. Sci Transl Med. 2016 08 24; 8(353):353ra111.Sci Transl Med2016-08-24T00:00:002016Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses.Authorship 56057912022-07-31SERHAN, CHARLES NICHOLAS1987-07-01Blood Cell Lipoxygenase Products -- Formation and ActionR01GM0387652005-03-31SERHAN, CHARLES NICHOLAS2000-04-01MOLECULAR MECHANISMS IN LEUKOCYTE-MEDIATED TISSUE INJURYP01DE0134992011-09-29BAZAN, NICOLAS GUILLERMO2009-09-30Mechanism of action of omega-3 fatty acids in brain injuryRC2AT0059091992-06-30SERHAN, CHARLES NICHOLAS1987-07-01BLOOD CELL LIPOXYGENASE PRODUCTS--FORMATION &ACTIONR29GM0387652015-08-31JI, RU-RONG2009-09-15Resolvins, protectins, and chronic pain resolution.R01NS0676862016-07-31PANIGRAHY, DIPAK2012-09-18Controlling cancer with aspirin-triggered stimulation of resolutionR01CA1705492010-06-30SERHAN, CHARLES NICHOLAS1987-07-01BLOOD CELL LIPOXYGENASE PRODUCTS--FORMATION AND ACTIONR37GM0387652015-07-31SERHAN, CHARLES NICHOLAS2004-09-17Specialized Center for Oral Inflammation and ResolutionP50DE0161912013-05-31SERHAN, CHARLES NICHOLAS2009-07-17Novel Mechanisms in Resolution to Harness Inflammation for ReconstructionR01DE0199382005-04-30ARNAOUT, M. AMIN1989-09-30THE PHAGOCYTE MEMBRANEP01DK0503052015-06-30LUSCINSKAS, FRANCIS W.1984-07-01Pathophysiology of the EndotheliumP01HL0360282017-06-30PERRELLA, MARK A2011-08-15Carbon Monoxide: Novel Opportunities for TherapyP01HL1088012011-01-31SERHAN, CHARLES NICHOLAS2005-09-15PHAGOCYTE RESOLVING METABOLISMR01DK0744482002-08-31ISRAEL, ELLIOT1996-09-01INFLAMMATORY EVENTS INITIATING AND PERPETUATING ASTHMAP50HL0563832021-03-31SERHAN, CHARLES NICHOLAS2011-04-01Resolution Mechanisms in Acute Inflammation: Resolution PharmacologyP01GM0954671991-06-30SERHAN, CHARLES NICHOLAS1988-07-01EVALUATION OF LIPOXYGENASE-DERIVED PRODUCTS AS MEDIATORSR01AI026714Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorPrincipal InvestigatorCo-Principal InvestigatorAuthorship 912482627534559Arnardottir HH, Dalli J, Norling LV, Colas RA, Perretti M, Serhan CNJournal of immunology (Baltimore, Md. : 1950)Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. J Immunol. 2016 09 15; 197(6):2362-8.J Immunol2016-08-17T00:00:002016Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation.Authorship 620379Authorship 78192Authorship 792651Authorship 923862Authorship 3359521Authorship 340682627791009Dalli J, Vlasakov I, Riley IR, Rodriguez AR, Spur BW, Petasis NA, Chiang N, Serhan CNProceedings of the National Academy of Sciences of the United States of AmericaMaresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages. Proc Natl Acad Sci U S A. 2016 10 25; 113(43):12232-12237.Proc Natl Acad Sci U S A2016-10-06T00:00:002016Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages.Authorship 3942583Authorship 3948713Authorship 9250515Authorship 9195917Authorship 92136511Authorship 9249216Authorship 9276565Authorship 9234401127513357Tsoyi K, Hall SR, Dalli J, Colas RA, Ghanta S, Ith B, Coronata A, Fredenburgh LE, Baron RM, Choi AM, Serhan CN, Liu X, Perrella MACritical care medicineCarbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators. Crit Care Med. 2016 Dec; 44(12):e1236-e1245.Crit Care Med2016-12-01T00:00:002016Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators.27072607Hodges RR, Li D, Shatos MA, Bair JA, Lippestad M, Serhan CN, Dartt DAMucosal immunologyLipoxin A4 activates ALX/FPR2 receptor to regulate conjunctival goblet cell secretion. Mucosal Immunol. 2017 01; 10(1):46-57.Mucosal Immunol2016-04-13T00:00:002016Lipoxin A4 activates ALX/FPR2 receptor to regulate conjunctival goblet cell secretion.Authorship 415844527647830Titos E, Rius B, López-Vicario C, Alcaraz-Quiles J, García-Alonso V, Lopategi A, Dalli J, Lozano JJ, Arroyo V, Delgado S, Serhan CN, Clària JJournal of immunology (Baltimore, Md. : 1950)Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue. J Immunol. 2016 10 15; 197(8):3360-3370.J Immunol2016-09-19T00:00:002016Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue.27704804Primdahl KG, Aursnes M, Walker ME, Colas RA, Serhan CN, Dalli J, Hansen TV, Vik AJournal of natural productsSynthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins. J Nat Prod. 2016 10 28; 79(10):2693-2702.J Nat Prod2016-10-05T00:00:002016Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins.Authorship 4297135Authorship 4351547Authorship 453221127799313Colas RA, Dalli J, Chiang N, Vlasakov I, Sanger JM, Riley IR, Serhan CNJournal of immunology (Baltimore, Md. : 1950)Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation. J Immunol. 2016 12 01; 197(11):4444-4452.J Immunol2016-10-31T00:00:002016Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation.Authorship 4848791Authorship 5488584Authorship 93269319Authorship 9300617Authorship 9300844Authorship 9355958Authorship 9346716Authorship 930857826858146Norris PC, Arnardottir H, Sanger JM, Fichtner D, Keyes GS, Serhan CNProstaglandins, leukotrienes, and essential fatty acidsResolvin D3 multi-level proresolving actions are host protective during infection. Prostaglandins Leukot Essent Fatty Acids. 2018 11; 138:81-89.Prostaglandins Leukot Essent Fatty Acids2016-01-22T00:00:002016Resolvin D3 multi-level proresolving actions are host protective during infection.27824117Hodges RR, Li D, Shatos MA, Serhan CN, Dartt DAScientific reportsLipoxin A4 Counter-regulates Histamine-stimulated Glycoconjugate Secretion in Conjunctival Goblet Cells. Sci Rep. 2016 11 08; 6:36124.Sci Rep2016-11-08T00:00:002016Lipoxin A4 Counter-regulates Histamine-stimulated Glycoconjugate Secretion in Conjunctival Goblet Cells.Authorship 601097Authorship 658222Authorship 678711Authorship 858463Authorship 2216645Authorship 2230073Authorship 3092613Authorship 940242827632672Dalli J, Colas RA, Quintana C, Barragan-Bradford D, Hurwitz S, Levy BD, Choi AM, Serhan CN, Baron RMCritical care medicineHuman Sepsis Eicosanoid and Proresolving Lipid Mediator Temporal Profiles: Correlations With Survival and Clinical Outcomes. Crit Care Med. 2017 Jan; 45(1):58-68.Crit Care Med2017-01-01T00:00:002017Human Sepsis Eicosanoid and Proresolving Lipid Mediator Temporal Profiles: Correlations With Survival and Clinical Outcomes.Authorship 3566395Authorship 3617131Authorship 374048Authorship 3897065Authorship 9417003Authorship 941935427994073Freire MO, Dalli J, Serhan CN, Van Dyke TEJournal of immunology (Baltimore, Md. : 1950)Neutrophil Resolvin E1 Receptor Expression and Function in Type 2 Diabetes. J Immunol. 2017 01 15; 198(2):718-728.J Immunol2016-12-19T00:00:002016Neutrophil Resolvin E1 Receptor Expression and Function in Type 2 Diabetes.27994074Chiang N, de la Rosa X, Libreros S, Serhan CNJournal of immunology (Baltimore, Md. : 1950)Novel Resolvin D2 Receptor Axis in Infectious Inflammation. J Immunol. 2017 01 15; 198(2):842-851.J Immunol2016-12-19T00:00:002016Novel Resolvin D2 Receptor Axis in Infectious Inflammation.Authorship 4019302Authorship 4218096Authorship 945806228029929Ramaswami R, Serhan CN, Levy BD, Makrides MThe New England journal of medicineFish Oil Supplementation in Pregnancy. N Engl J Med. 2016 12 29; 375(26):2599-2601.N Engl J Med2016-12-29T00:00:002016Fish Oil Supplementation in Pregnancy.Authorship 44064512Authorship 45167315Authorship 4712729Authorship 4713949Authorship 4788918Authorship 9490331Authorship 949607428065837Dalli J, Colas RA, Arnardottir H, Serhan CNImmunityVagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution. Immunity. 2017 01 17; 46(1):92-105.Immunity2017-01-05T00:00:002017Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution.28087575Serhan CNFASEB journal : official publication of the Federation of American Societies for Experimental BiologyTreating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms. FASEB J. 2017 04; 31(4):1273-1288.FASEB J2017-01-13T00:00:002017Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms.Authorship 5096503Authorship 5243232Authorship 958554328218420Fedirko V, McKeown-Eyssen G, Serhan CN, Barry EL, Sandler RS, Figueiredo JC, Ahnen DJ, Bresalier RS, Robertson DJ, Anderson CW, Baron JAMolecular carcinogenesisPlasma lipoxin A4 and resolvin D1 are not associated with reduced adenoma risk in a randomized trial of aspirin to prevent colon adenomas. Mol Carcinog. 2017 08; 56(8):1977-1983.Mol Carcinog2017-03-06T00:00:002017Plasma lipoxin A4 and resolvin D1 are not associated with reduced adenoma risk in a randomized trial of aspirin to prevent colon adenomas.8834158Brady HR, Serhan CNCurrent opinion in nephrology and hypertensionLipoxins: putative braking signals in host defense, inflammation and hypersensitivity. Curr Opin Nephrol Hypertens. 1996 Jan; 5(1):20-7.Curr Opin Nephrol Hypertens1996-01-01T00:00:001996Lipoxins: putative braking signals in host defense, inflammation and hypersensitivity.8751717Serhan CN, Haeggström JZ, Leslie CCFASEB journal : official publication of the Federation of American Societies for Experimental BiologyLipid mediator networks in cell signaling: update and impact of cytokines. FASEB J. 1996 Aug; 10(10):1147-58.FASEB J1996-08-01T00:00:001996Lipid mediator networks in cell signaling: update and impact of cytokines.8757340Romano M, Maddox JF, Serhan CNJournal of immunology (Baltimore, Md. : 1950)Activation of human monocytes and the acute monocytic leukemia cell line (THP-1) by lipoxins involves unique signaling pathways for lipoxin A4 versus lipoxin B4: evidence for differential Ca2+ mobilization. J Immunol. 1996 Sep 01; 157(5):2149-54.J Immunol1996-09-01T00:00:001996Activation of human monocytes and the acute monocytic leukemia cell line (THP-1) by lipoxins involves unique signaling pathways for lipoxin A4 versus lipoxin B4: evidence for differential Ca2+ mobilization.9462731D'Andrea AD, Serhan CNNature geneticsRelieving the Itch. Nat Genet. 1998 Feb; 18(2):97-9.Nat Genet1998-02-01T00:00:001998Relieving the Itch.9547339Gronert K, Gewirtz A, Madara JL, Serhan CNThe Journal of experimental medicineIdentification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release. J Exp Med. 1998 Apr 20; 187(8):1285-94.J Exp Med1998-04-20T00:00:001998Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release.12368905Perretti M, Chiang N, La M, Fierro IM, Marullo S, Getting SJ, Solito E, Serhan CNNature medicineEndogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nat Med. 2002 Nov; 8(11):1296-302.Nat Med2002-10-07T00:00:002002Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor.15716788Serhan CNCurrent opinion in clinical nutrition and metabolic careNovel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectins. Curr Opin Clin Nutr Metab Care. 2005 Mar; 8(2):115-21.Curr Opin Clin Nutr Metab Care2005-03-01T00:00:002005Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectins.15726828Serhan CN, Arita M, Hong S, Gotlinger KLipidsResolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers. Lipids. 2004 Nov; 39(11):1125-32.Lipids2004-11-01T00:00:002004Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers.16125378Chiang N, Arita M, Serhan CNProstaglandins, leukotrienes, and essential fatty acidsAnti-inflammatory circuitry: lipoxin, aspirin-triggered lipoxins and their receptor ALX. Prostaglandins Leukot Essent Fatty Acids. 2005 Sep-Oct; 73(3-4):163-77.Prostaglandins Leukot Essent Fatty Acids2005-09-01T00:00:002005Anti-inflammatory circuitry: lipoxin, aspirin-triggered lipoxins and their receptor ALX.2010431Serhan CNJournal of bioenergetics and biomembranesLipoxins: eicosanoids carrying intra- and intercellular messages. J Bioenerg Biomembr. 1991 Feb; 23(1):105-22.J Bioenerg Biomembr1991-02-01T00:00:001991Lipoxins: eicosanoids carrying intra- and intercellular messages.16757471Arita M, Oh SF, Chonan T, Hong S, Elangovan S, Sun YP, Uddin J, Petasis NA, Serhan CNThe Journal of biological chemistryMetabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions. J Biol Chem. 2006 Aug 11; 281(32):22847-54.J Biol Chem2006-06-06T00:00:002006Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions.16940150Wada K, Arita M, Nakajima A, Katayama K, Kudo C, Kamisaki Y, Serhan CNFASEB journal : official publication of the Federation of American Societies for Experimental BiologyLeukotriene B4 and lipoxin A4 are regulatory signals for neural stem cell proliferation and differentiation. FASEB J. 2006 Sep; 20(11):1785-92.FASEB J2006-09-01T00:00:002006Leukotriene B4 and lipoxin A4 are regulatory signals for neural stem cell proliferation and differentiation.10224233Levy BD, Fokin VV, Clark JM, Wakelam MJ, Petasis NA, Serhan CNFASEB journal : official publication of the Federation of American Societies for Experimental BiologyPolyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a 'stop' signaling switch for aspirin-triggered lipoxin A4. FASEB J. 1999 May; 13(8):903-11.FASEB J1999-05-01T00:00:001999Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a 'stop' signaling switch for aspirin-triggered lipoxin A4.10636887Wright HM, Clish CB, Mikami T, Hauser S, Yanagi K, Hiramatsu R, Serhan CN, Spiegelman BMThe Journal of biological chemistryA synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation. J Biol Chem. 2000 Jan 21; 275(3):1873-7.J Biol Chem2000-01-21T00:00:002000A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation.12235371József L, Zouki C, Petasis NA, Serhan CN, Filep JGProceedings of the National Academy of Sciences of the United States of AmericaLipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):13266-71.Proc Natl Acad Sci U S A2002-09-16T00:00:002002Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-kappa B and AP-1 activation, and IL-8 gene expression in human leukocytes.12391014Serhan CN, Hong S, Gronert K, Colgan SP, Devchand PR, Mirick G, Moussignac RLThe Journal of experimental medicineResolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med. 2002 Oct 21; 196(8):1025-37.J Exp Med2002-10-21T00:00:002002Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals.15001665Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Rovati GE, Serhan CN, Shimizu T, Yokomizo TPharmacological reviewsInternational Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor. Pharmacol Rev. 2004 Mar; 56(1):149-57.Pharmacol Rev2004-03-01T00:00:002004International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor.15584868Serhan CNExpert opinion on therapeutic targetsClues for new therapeutics in osteoporosis and periodontal disease: new roles for lipoxygenases? Expert Opin Ther Targets. 2004 Dec; 8(6):643-52.Expert Opin Ther Targets2004-12-01T00:00:002004Clues for new therapeutics in osteoporosis and periodontal disease: new roles for lipoxygenases?15778399Bannenberg GL, Chiang N, Ariel A, Arita M, Tjonahen E, Gotlinger KH, Hong S, Serhan CNJournal of immunology (Baltimore, Md. : 1950)Molecular circuits of resolution: formation and actions of resolvins and protectins. J Immunol. 2005 Apr 01; 174(7):4345-55.J Immunol2005-04-01T00:00:002005Molecular circuits of resolution: formation and actions of resolvins and protectins.9547614Brady HR, Papayianni A, Serhan CNAdvances in experimental medicine and biologyTranscellular pathways and cell adhesion as potential contributors to leukotriene and lipoxin biosynthesis in acute glomerulonephritis. Adv Exp Med Biol. 1997; 400B:631-40.Adv Exp Med Biol1997-01-01T00:00:001997Transcellular pathways and cell adhesion as potential contributors to leukotriene and lipoxin biosynthesis in acute glomerulonephritis.9808710Chiang N, Takano T, Clish CB, Petasis NA, Tai HH, Serhan CNThe Journal of pharmacology and experimental therapeuticsAspirin-triggered 15-epi-lipoxin A4 (ATL) generation by human leukocytes and murine peritonitis exudates: development of a specific 15-epi-LXA4 ELISA. J Pharmacol Exp Ther. 1998 Nov; 287(2):779-90.J Pharmacol Exp Ther1998-11-01T00:00:001998Aspirin-triggered 15-epi-lipoxin A4 (ATL) generation by human leukocytes and murine peritonitis exudates: development of a specific 15-epi-LXA4 ELISA.Authorship 964556327525060Hansen TV, Dalli J, Serhan CNRSC advancesSelective identification of specialized pro-resolving lipid mediators from their biosynthetic double di-oxygenation isomers. RSC Adv. 2016; 6(34):28820-28829.RSC Adv2016-03-04T00:00:002016Selective identification of specialized pro-resolving lipid mediators from their biosynthetic double di-oxygenation isomers.11192938Serhan CN, Clish CB, Brannon J, Colgan SP, Gronert K, Chiang NJournal of physiology and pharmacology : an official journal of the Polish Physiological SocietyAnti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actions. J Physiol Pharmacol. 2000 Dec; 51(4 Pt 1):643-54.J Physiol Pharmacol2000-12-01T00:00:002000Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actions.Authorship 96663813Authorship 9688011Authorship 968604528263773Serhan CNMolecular aspects of medicineDiscovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology. Mol Aspects Med. 2017 Dec; 58:1-11.Mol Aspects Med2017-03-03T00:00:002017Discovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology.28245134Lee S, Nakahira K, Dalli J, Siempos II, Norris PC, Colas RA, Moon JS, Shinohara M, Hisata S, Howrylak JA, Suh GY, Ryter SW, Serhan CN, Choi AMKAmerican journal of respiratory and critical care medicineNLRP3 Inflammasome Deficiency Protects against Microbial Sepsis via Increased Lipoxin B4 Synthesis. Am J Respir Crit Care Med. 2017 09 15; 196(6):713-726.Am J Respir Crit Care Med2017-09-15T00:00:002017NLRP3 Inflammasome Deficiency Protects against Microbial Sepsis via Increased Lipoxin B4 Synthesis.28237084English JT, Norris PC, Hodges RR, Dartt DA, Serhan CNProstaglandins, leukotrienes, and essential fatty acidsIdentification and Profiling of Specialized Pro-Resolving Mediators in Human Tears by Lipid Mediator Metabolomics. Prostaglandins Leukot Essent Fatty Acids. 2017 02; 117:17-27.Prostaglandins Leukot Essent Fatty Acids2017-01-19T00:00:002017Identification and Profiling of Specialized Pro-Resolving Mediators in Human Tears by Lipid Mediator Metabolomics.1415572Katoh T, Takahashi K, DeBoer DK, Serhan CN, Badr KFThe American journal of physiologyRenal hemodynamic actions of lipoxins in rats: a comparative physiological study. Am J Physiol. 1992 Sep; 263(3 Pt 2):F436-42.Am J Physiol1992-09-01T00:00:001992Renal hemodynamic actions of lipoxins in rats: a comparative physiological study.10590058Filep JG, Zouki C, Petasis NA, Hachicha M, Serhan CNBloodAnti-inflammatory actions of lipoxin A(4) stable analogs are demonstrable in human whole blood: modulation of leukocyte adhesion molecules and inhibition of neutrophil-endothelial interactions. Blood. 1999 Dec 15; 94(12):4132-42.Blood1999-12-15T00:00:001999Anti-inflammatory actions of lipoxin A(4) stable analogs are demonstrable in human whole blood: modulation of leukocyte adhesion molecules and inhibition of neutrophil-endothelial interactions.10760293Qiu FH, Wada K, Stahl GL, Serhan CNProceedings of the National Academy of Sciences of the United States of AmericaIMP and AMP deaminase in reperfusion injury down-regulates neutrophil recruitment. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4267-72.Proc Natl Acad Sci U S A2000-04-11T00:00:002000IMP and AMP deaminase in reperfusion injury down-regulates neutrophil recruitment.16968948Chiang N, Serhan CN, Dahlén SE, Drazen JM, Hay DW, Rovati GE, Shimizu T, Yokomizo T, Brink CPharmacological reviewsThe lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo. Pharmacol Rev. 2006 Sep; 58(3):463-87.Pharmacol Rev2006-09-01T00:00:002006The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo.10769133Pouliot M, Clish CB, Petasis NA, Van Dyke TE, Serhan CNBiochemistryLipoxin A(4) analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: a role for cyclooxygenase-2 and lipoxins in periodontal disease. Biochemistry. 2000 Apr 25; 39(16):4761-8.Biochemistry2000-04-25T00:00:002000Lipoxin A(4) analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: a role for cyclooxygenase-2 and lipoxins in periodontal disease.11276361Wada K, Qiu FH, Stahl GL, Serhan CNJournal of hematotherapy & stem cell researchInosine monophosphate and aspirin-triggered 15-epi-lipoxin A4 act in concert to regulate neutrophil trafficking: additive actions of two new endogenous anti-inflammatory mediators. J Hematother Stem Cell Res. 2001 Feb; 10(1):75-9.J Hematother Stem Cell Res2001-02-01T00:00:002001Inosine monophosphate and aspirin-triggered 15-epi-lipoxin A4 act in concert to regulate neutrophil trafficking: additive actions of two new endogenous anti-inflammatory mediators.11429545Levy BD, Clish CB, Schmidt B, Gronert K, Serhan CNNature immunologyLipid mediator class switching during acute inflammation: signals in resolution. Nat Immunol. 2001 Jul; 2(7):612-9.Nat Immunol2001-07-01T00:00:002001Lipid mediator class switching during acute inflammation: signals in resolution.17954222Serhan CN, Lu Y, Hong S, Yang RMethods in enzymologyMediator lipidomics: search algorithms for eicosanoids, resolvins, and protectins. Methods Enzymol. 2007; 432:275-317.Methods Enzymol2007-01-01T00:00:002007Mediator lipidomics: search algorithms for eicosanoids, resolvins, and protectins.19008087Serhan CNProstaglandins, leukotrienes, and essential fatty acidsSystems approach with inflammatory exudates uncovers novel anti-inflammatory and pro-resolving mediators. Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov; 79(3-5):157-63.Prostaglandins Leukot Essent Fatty Acids2008-11-12T00:00:002008Systems approach with inflammatory exudates uncovers novel anti-inflammatory and pro-resolving mediators.19931440Marcheselli VL, Mukherjee PK, Arita M, Hong S, Antony R, Sheets K, Winkler JW, Petasis NA, Serhan CN, Bazan NGProstaglandins, leukotrienes, and essential fatty acidsNeuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils. Prostaglandins Leukot Essent Fatty Acids. 2010 Jan; 82(1):27-34.Prostaglandins Leukot Essent Fatty Acids2010-01-01T00:00:002010Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils.Authorship 973324228336292Chiang N, Serhan CNMolecular aspects of medicineStructural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors. Mol Aspects Med. 2017 Dec; 58:114-129.Mol Aspects Med2017-03-31T00:00:002017Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors.12664586Titos E, Chiang N, Serhan CN, Romano M, Gaya J, Pueyo G, Clària JAdvances in experimental medicine and biologyAspirin-triggered 15-epi-lipoxin A4 biosynthesis in rat liver cells. Adv Exp Med Biol. 2002; 507:199-209.Adv Exp Med Biol2002-01-01T00:00:002002Aspirin-triggered 15-epi-lipoxin A4 biosynthesis in rat liver cells.14507911Sharon R, Bar-Joseph I, Mirick GE, Serhan CN, Selkoe DJThe Journal of biological chemistryAltered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies. J Biol Chem. 2003 Dec 12; 278(50):49874-81.J Biol Chem2003-09-23T00:00:002003Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies.Authorship 9740971128356517Gobbetti T, Dalli J, Colas RA, Federici Canova D, Aursnes M, Bonnet D, Alric L, Vergnolle N, Deraison C, Hansen TV, Serhan CN, Perretti MProceedings of the National Academy of Sciences of the United States of AmericaProtectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection. Proc Natl Acad Sci U S A. 2017 04 11; 114(15):3963-3968.Proc Natl Acad Sci U S A2017-03-29T00:00:002017Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection.9054386Maddox JF, Hachicha M, Takano T, Petasis NA, Fokin VV, Serhan CNThe Journal of biological chemistryLipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor. 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Biochemistry. 1992 Sep 08; 31(35):8269-77.Biochemistry1992-09-08T00:00:001992Lipoxin generation by permeabilized human platelets.60 Fenwood RdBrigham and Women3016n60 Fenwood RdBoston02115MA19572372Ishida T, Yoshida M, Arita M, Nishitani Y, Nishiumi S, Masuda A, Mizuno S, Takagawa T, Morita Y, Kutsumi H, Inokuchi H, Serhan CN, Blumberg RS, Azuma TInflammatory bowel diseasesResolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium-induced colitis. Inflamm Bowel Dis. 2010 Jan; 16(1):87-95.Inflamm Bowel Dis2010-01-01T00:00:002010Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium-induced colitis.20869861Levy BD, Zhang QY, Bonnans C, Primo V, Reilly JJ, Perkins DL, Liang Y, Amin Arnaout M, Nikolic B, Serhan CNProstaglandins, leukotrienes, and essential fatty acidsThe endogenous pro-resolving mediators lipoxin A4 and resolvin E1 preserve organ function in allograft rejection. 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Biochem Biophys Res Commun. 1992 Aug 14; 186(3):1307-14.Biochem Biophys Res Commun1992-08-14T00:00:001992Adhesion promotes transcellular leukotriene biosynthesis during neutrophil-glomerular endothelial cell interactions: inhibition by antibodies against CD18 and L-selectin.18233953Serhan CN, Yacoubian S, Yang RAnnual review of pathologyAnti-inflammatory and proresolving lipid mediators. Annu Rev Pathol. 2008; 3:279-312.Annu Rev Pathol2008-01-01T00:00:002008Anti-inflammatory and proresolving lipid mediators.11687510Qiu FH, Devchand PR, Wada K, Serhan CNFASEB journal : official publication of the Federation of American Societies for Experimental BiologyAspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils. FASEB J. 2001 Dec; 15(14):2736-8.FASEB J2001-10-29T00:00:002001Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils.11688989Clish CB, Sun YP, Serhan CNBiochemical and biophysical research communicationsIdentification of dual cyclooxygenase-eicosanoid oxidoreductase inhibitors: NSAIDs that inhibit PG-LX reductase/LTB(4) dehydrogenase. Biochem Biophys Res Commun. 2001 Nov 09; 288(4):868-74.Biochem Biophys Res Commun2001-11-09T00:00:002001Identification of dual cyclooxygenase-eicosanoid oxidoreductase inhibitors: NSAIDs that inhibit PG-LX reductase/LTB(4) dehydrogenase.19124557Zurier RB, Sun YP, George KL, Stebulis JA, Rossetti RG, Skulas A, Judge E, Serhan CNFASEB journal : official publication of the Federation of American Societies for Experimental BiologyAjulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4. FASEB J. 2009 May; 23(5):1503-9.FASEB J2009-01-05T00:00:002009Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4.12746227Chiang N, Takano T, Arita M, Watanabe S, Serhan CNBritish journal of pharmacologyA novel rat lipoxin A4 receptor that is conserved in structure and function. Br J Pharmacol. 2003 May; 139(1):89-98.Br J Pharmacol2003-05-01T00:00:002003A novel rat lipoxin A4 receptor that is conserved in structure and function.12923200Marcheselli VL, Hong S, Lukiw WJ, Tian XH, Gronert K, Musto A, Hardy M, Gimenez JM, Chiang N, Serhan CN, Bazan NGThe Journal of biological chemistryNovel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J Biol Chem. 2003 Oct 31; 278(44):43807-17.J Biol Chem2003-08-15T00:00:002003Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression.22450811Oh SF, Dona M, Fredman G, Krishnamoorthy S, Irimia D, Serhan CNJournal of immunology (Baltimore, Md. : 1950)Resolvin E2 formation and impact in inflammation resolution. J Immunol. 2012 May 01; 188(9):4527-34.J Immunol2012-03-26T00:00:002012Resolvin E2 formation and impact in inflammation resolution.22566962Shinohara M, Mirakaj V, Serhan CNFrontiers in immunologyFunctional Metabolomics Reveals Novel Active Products in the DHA Metabolome. Front Immunol. 2012; 3:81.Front Immunol2012-04-17T00:00:002012Functional Metabolomics Reveals Novel Active Products in the DHA Metabolome.22957142Fredman G, Li Y, Dalli J, Chiang N, Serhan CNScientific reportsSelf-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA. Sci Rep. 2012; 2:639.Sci Rep2012-09-06T00:00:002012Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA.23093949Recchiuti A, Serhan CNFrontiers in immunologyPro-Resolving Lipid Mediators (SPMs) and Their Actions in Regulating miRNA in Novel Resolution Circuits in Inflammation. Front Immunol. 2012; 3:298.Front Immunol2012-10-22T00:00:002012Pro-Resolving Lipid Mediators (SPMs) and Their Actions in Regulating miRNA in Novel Resolution Circuits in Inflammation.21255928Huang L, Wang CF, Serhan CN, Strichartz GPainEnduring prevention and transient reduction of postoperative pain by intrathecal resolvin D1. Pain. 2011 Mar; 152(3):557-565.Pain2011-01-20T00:00:002011Enduring prevention and transient reduction of postoperative pain by intrathecal resolvin D1.1825593Fiore S, Romano M, Serhan CNAdvances in prostaglandin, thromboxane, and leukotriene researchLipoxin and leukotriene production during receptor-activated interactions between human platelets and cytokine-primed neutrophils. Adv Prostaglandin Thromboxane Leukot Res. 1991; 21A:93-6.Adv Prostaglandin Thromboxane Leukot Res1991-01-01T00:00:001991Lipoxin and leukotriene production during receptor-activated interactions between human platelets and cytokine-primed neutrophils.16041402Levy BD, Hickey L, Morris AJ, Larvie M, Keledjian R, Petasis NA, Bannenberg G, Serhan CNBritish journal of pharmacologyNovel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo. Br J Pharmacol. 2005 Oct; 146(3):344-51.Br J Pharmacol2005-10-01T00:00:002005Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo.3421160Brasseur R, Serhan CN, Deleers MAdvances in experimental medicine and biologyComputed conformational analysis of lipoxins and their ionic complexes. Adv Exp Med Biol. 1988; 229:93-106.Adv Exp Med Biol1988-01-01T00:00:001988Computed conformational analysis of lipoxins and their ionic complexes.Authorship 998003428694292Diaz LA, Altman NH, Khan WN, Serhan CN, Adkins BInfection and immunitySpecialized Proresolving Mediators Rescue Infant Mice from Lethal Citrobacter rodentium Infection and Promote Immunity against Reinfection. Infect Immun. 2017 10; 85(10).Infect Immun2017-09-20T00:00:002017Specialized Proresolving Mediators Rescue Infant Mice from Lethal Citrobacter rodentium Infection and Promote Immunity against Reinfection.6088611Marcus AJ, Safier LB, Broekman MJ, Ullman HL, Islam N, Sorrell TC, Serhan CN, Weissmann G, Oglesby TD, Gorman RRThe Journal of allergy and clinical immunologyProduction of metabolic products of arachidonic acid during cell-cell interactions. J Allergy Clin Immunol. 1984 Sep; 74(3 Pt 2):338-42.J Allergy Clin Immunol1984-09-01T00:00:001984Production of metabolic products of arachidonic acid during cell-cell interactions.8376607Levy BD, Romano M, Chapman HA, Reilly JJ, Drazen J, Serhan CNThe Journal of clinical investigationHuman alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins. J Clin Invest. 1993 Sep; 92(3):1572-9.J Clin Invest1993-09-01T00:00:001993Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins.15890784Arita M, Yoshida M, Hong S, Tjonahen E, Glickman JN, Petasis NA, Blumberg RS, Serhan CNProceedings of the National Academy of Sciences of the United States of AmericaResolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc Natl Acad Sci U S A. 2005 May 24; 102(21):7671-6.Proc Natl Acad Sci U S A2005-05-12T00:00:002005Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis.15931391Bafica A, Scanga CA, Serhan C, Machado F, White S, Sher A, Aliberti JThe Journal of clinical investigationHost control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production. J Clin Invest. 2005 Jun; 115(6):1601-6.J Clin Invest2005-06-01T00:00:002005Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production.16151530Lukiw WJ, Cui JG, Marcheselli VL, Bodker M, Botkjaer A, Gotlinger K, Serhan CN, Bazan NGThe Journal of clinical investigationA role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J Clin Invest. 2005 Oct; 115(10):2774-83.J Clin Invest2005-10-01T00:00:002005A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease.16369558Serhan CN, Savill JNature immunologyResolution of inflammation: the beginning programs the end. Nat Immunol. 2005 Dec; 6(12):1191-7.Nat Immunol2005-12-01T00:00:002005Resolution of inflammation: the beginning programs the end.16847262Hudert CA, Weylandt KH, Lu Y, Wang J, Hong S, Dignass A, Serhan CN, Kang JXProceedings of the National Academy of Sciences of the United States of AmericaTransgenic mice rich in endogenous omega-3 fatty acids are protected from colitis. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11276-81.Proc Natl Acad Sci U S A2006-07-17T00:00:002006Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis.17339491Arita M, Ohira T, Sun YP, Elangovan S, Chiang N, Serhan CNJournal of immunology (Baltimore, Md. : 1950)Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. J Immunol. 2007 Mar 15; 178(6):3912-7.J Immunol2007-03-15T00:00:002007Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation.17589522Connor KM, SanGiovanni JP, Lofqvist C, Aderman CM, Chen J, Higuchi A, Hong S, Pravda EA, Majchrzak S, Carper D, Hellstrom A, Kang JX, Chew EY, Salem N, Serhan CN, Smith LEHNature medicineIncreased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med. 2007 Jul; 13(7):868-873.Nat Med2007-06-24T00:00:002007Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis.20702811Fredman G, Van Dyke TE, Serhan CNArteriosclerosis, thrombosis, and vascular biologyResolvin E1 regulates adenosine diphosphate activation of human platelets. Arterioscler Thromb Vasc Biol. 2010 Oct; 30(10):2005-13.Arterioscler Thromb Vasc Biol2010-08-11T00:00:002010Resolvin E1 regulates adenosine diphosphate activation of human platelets.8527441Fiore S, Serhan CNBiochemistryLipoxin A4 receptor activation is distinct from that of the formyl peptide receptor in myeloid cells: inhibition of CD11/18 expression by lipoxin A4-lipoxin A4 receptor interaction. Biochemistry. 1995 Dec 26; 34(51):16678-86.Biochemistry1995-12-26T00:00:001995Lipoxin A4 receptor activation is distinct from that of the formyl peptide receptor in myeloid cells: inhibition of CD11/18 expression by lipoxin A4-lipoxin A4 receptor interaction.16373400Hasturk H, Kantarci A, Ohira T, Arita M, Ebrahimi N, Chiang N, Petasis NA, Levy BD, Serhan CN, Van Dyke TEFASEB journal : official publication of the Federation of American Societies for Experimental BiologyRvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis. FASEB J. 2006 Feb; 20(2):401-3.FASEB J2005-12-22T00:00:002005RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis.17013391Ariel A, Fredman G, Sun YP, Kantarci A, Van Dyke TE, Luster AD, Serhan CNNature immunologyApoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression. Nat Immunol. 2006 Nov; 7(11):1209-16.Nat Immunol2006-10-01T00:00:002006Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression.17073024Serhan CN, Wasserman SIThe Journal of allergy and clinical immunologyThe allergy archives: pioneer and milestones. The discovery and characterization of the leukotrienes. J Allergy Clin Immunol. 2006 Oct; 118(4):972-80.J Allergy Clin Immunol2006-10-01T00:00:002006The allergy archives: pioneer and milestones. The discovery and characterization of the leukotrienes.9023996Bowden LA, Fiore S, Restall CJ, Serhan CN, Rowley AFThe Journal of experimental biologyCharacterisation of the binding of leukotriene B4 to macrophages of the rainbow trout Oncorhynchus mykiss. J Exp Biol. 1997 Jan; 200(Pt 1):155-60.J Exp Biol1997-01-01T00:00:001997Characterisation of the binding of leukotriene B4 to macrophages of the rainbow trout Oncorhynchus mykiss.9275235Scalia R, Gefen J, Petasis NA, Serhan CN, Lefer AMProceedings of the National Academy of Sciences of the United States of AmericaLipoxin A4 stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature: role of P-selectin. Proc Natl Acad Sci U S A. 1997 Sep 02; 94(18):9967-72.Proc Natl Acad Sci U S A1997-09-02T00:00:001997Lipoxin A4 stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature: role of P-selectin.22904297Dalli J, Serhan CNBloodSpecific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators. Blood. 2012 Oct 11; 120(15):e60-72.Blood2012-08-17T00:00:002012Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators.9535221Maddox JF, Colgan SP, Clish CB, Petasis NA, Fokin VV, Serhan CNFASEB journal : official publication of the Federation of American Societies for Experimental BiologyLipoxin B4 regulates human monocyte/neutrophil adherence and motility: design of stable lipoxin B4 analogs with increased biologic activity. FASEB J. 1998 Apr; 12(6):487-94.FASEB J1998-04-01T00:00:001998Lipoxin B4 regulates human monocyte/neutrophil adherence and motility: design of stable lipoxin B4 analogs with increased biologic activity.9547615Serhan CNAdvances in experimental medicine and biologyLipoxin metabolism by human promyelocytic leukemia (HL-60) cells. Adv Exp Med Biol. 1997; 400B:641-6.Adv Exp Med Biol1997-01-01T00:00:001997Lipoxin metabolism by human promyelocytic leukemia (HL-60) cells.10748237Chiang N, Fierro IM, Gronert K, Serhan CNThe Journal of experimental medicineActivation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation. J Exp Med. 2000 Apr 03; 191(7):1197-208.J Exp Med2000-04-03T00:00:002000Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation.10973792Levy BD, Serhan CNBiochemical and biophysical research communicationsPolyisoprenyl phosphate signaling: topography in human neutrophils. Biochem Biophys Res Commun. 2000 Sep 07; 275(3):739-45.Biochem Biophys Res Commun2000-09-07T00:00:002000Polyisoprenyl phosphate signaling: topography in human neutrophils.11141472Gronert K, Martinsson-Niskanen T, Ravasi S, Chiang N, Serhan CNThe American journal of pathologySelectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. Am J Pathol. 2001 Jan; 158(1):3-9.Am J Pathol2001-01-01T00:00:002001Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses.17568749Schwab JM, Chiang N, Arita M, Serhan CNNatureResolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature. 2007 Jun 14; 447(7146):869-74.Nature2007-06-14T00:00:002007Resolvin E1 and protectin D1 activate inflammation-resolution programmes.18382663Chiang N, Schwab JM, Fredman G, Kasuga K, Gelman S, Serhan CNPloS oneAnesthetics impact the resolution of inflammation. PLoS One. 2008 Apr 02; 3(4):e1879.PLoS One2008-04-02T00:00:002008Anesthetics impact the resolution of inflammation.28765512Norris PC, Libreros S, Chiang N, Serhan CNScience signalingA cluster of immunoresolvents links coagulation to innate host defense in human blood. Sci Signal. 2017 Aug 01; 10(490).Sci Signal2017-08-01T00:00:002017A cluster of immunoresolvents links coagulation to innate host defense in human blood.28802833Serhan CN, Chiang N, Dalli JMolecular aspects of medicineNew pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration. Mol Aspects Med. 2018 12; 64:1-17.Mol Aspects Med2017-09-01T00:00:002017New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration.Authorship 9998734Authorship 999884122332103Abumrad NA, Piomelli D, Yurko-Mauro K, Merrill A, Clandinin MT, Serhan CNAdvances in nutrition (Bethesda, Md.)Moving beyond "good fat, bad fat": the complex roles of dietary lipids in cellular function and health: session abstracts. Adv Nutr. 2012 Jan; 3(1):60-8.Adv Nutr2012-01-05T00:00:002012Moving beyond "good fat, bad fat": the complex roles of dietary lipids in cellular function and health: session abstracts.22929102Levy BD, Vachier I, Serhan CNClinics in chest medicineResolution of inflammation in asthma. Clin Chest Med. 2012 Sep; 33(3):559-70.Clin Chest Med2012-07-25T00:00:002012Resolution of inflammation in asthma.21934099Campbell EL, Serhan CN, Colgan SPJournal of immunology (Baltimore, Md. : 1950)Antimicrobial aspects of inflammatory resolution in the mucosa: a role for proresolving mediators. J Immunol. 2011 Oct 01; 187(7):3475-81.J Immunol2011-10-01T00:00:002011Antimicrobial aspects of inflammatory resolution in the mucosa: a role for proresolving mediators.21963090Ji RR, Xu ZZ, Strichartz G, Serhan CNTrends in neurosciencesEmerging roles of resolvins in the resolution of inflammation and pain. Trends Neurosci. 2011 Nov; 34(11):599-609.Trends Neurosci2011-09-30T00:00:002011Emerging roles of resolvins in the resolution of inflammation and pain.3083410Serhan CN, Hamberg M, Samuelsson B, Morris J, Wishka DGProceedings of the National Academy of Sciences of the United States of AmericaOn the stereochemistry and biosynthesis of lipoxin B. Proc Natl Acad Sci U S A. 1986 Apr; 83(7):1983-7.Proc Natl Acad Sci U S A1986-04-01T00:00:001986On the stereochemistry and biosynthesis of lipoxin B.3109942Serhan CN, Hirsch U, Palmblad J, Samuelsson BFEBS lettersFormation of lipoxin A by granulocytes from eosinophilic donors. FEBS Lett. 1987 Jun 15; 217(2):242-6.FEBS Lett1987-06-15T00:00:001987Formation of lipoxin A by granulocytes from eosinophilic donors.10564079Titos E, Chiang N, Serhan CN, Romano M, Gaya J, Pueyo G, Clària JThe American journal of physiologyHepatocytes are a rich source of novel aspirin-triggered 15-epi-lipoxin A(4). Am J Physiol. 1999 11; 277(5):C870-7.Am J Physiol1999-11-01T00:00:001999Hepatocytes are a rich source of novel aspirin-triggered 15-epi-lipoxin A(4).10933083Sanak M, Levy BD, Clish CB, Chiang N, Gronert K, Mastalerz L, Serhan CN, Szczeklik AThe European respiratory journalAspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics. Eur Respir J. 2000 Jul; 16(1):44-9.Eur Respir J2000-07-01T00:00:002000Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics.Authorship 1011346428892824Lippestad M, Hodges RR, Utheim TP, Serhan CN, Dartt DAInvestigative ophthalmology & visual scienceResolvin D1 Increases Mucin Secretion in Cultured Rat Conjunctival Goblet Cells via Multiple Signaling Pathways. Invest Ophthalmol Vis Sci. 2017 09 01; 58(11):4530-4544.Invest Ophthalmol Vis Sci2017-09-01T00:00:002017Resolvin D1 Increases Mucin Secretion in Cultured Rat Conjunctival Goblet Cells via Multiple Signaling Pathways.12594298Fierro IM, Colgan SP, Bernasconi G, Petasis NA, Clish CB, Arita M, Serhan CNJournal of immunology (Baltimore, Md. : 1950)Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration: comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells. J Immunol. 2003 Mar 01; 170(5):2688-94.J Immunol2003-03-01T00:00:002003Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit human neutrophil migration: comparisons between synthetic 15 epimers in chemotaxis and transmigration with microvessel endothelial cells and epithelial cells.1818482Fiore S, Brezinski ME, Sheppard KA, Serhan CNAdvances in experimental medicine and biologyThe lipoxin biosynthetic circuit and their actions with human neutrophils. Adv Exp Med Biol. 1991; 314:109-32.Adv Exp Med Biol1991-01-01T00:00:001991The lipoxin biosynthetic circuit and their actions with human neutrophils.15290791Serhan CN, Gotlinger K, Hong S, Arita MProstaglandins & other lipid mediatorsResolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis. Prostaglandins Other Lipid Mediat. 2004 Apr; 73(3-4):155-72.Prostaglandins Other Lipid Mediat2004-04-01T00:00:002004Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis.2117642Liu LX, Serhan CN, Weller PFThe Journal of experimental medicineIntravascular filarial parasites elaborate cyclooxygenase-derived eicosanoids. J Exp Med. 1990 Sep 01; 172(3):993-6.J Exp Med1990-09-01T00:00:001990Intravascular filarial parasites elaborate cyclooxygenase-derived eicosanoids.2172436Fiore S, Serhan CNThe Journal of experimental medicineFormation of lipoxins and leukotrienes during receptor-mediated interactions of human platelets and recombinant human granulocyte/macrophage colony-stimulating factor-primed neutrophils. J Exp Med. 1990 Nov 01; 172(5):1451-7.J Exp Med1990-11-01T00:00:001990Formation of lipoxins and leukotrienes during receptor-mediated interactions of human platelets and recombinant human granulocyte/macrophage colony-stimulating factor-primed neutrophils.18059001Masoodi M, Mir AA, Petasis NA, Serhan CN, Nicolaou ARapid communications in mass spectrometry : RCMSimultaneous lipidomic analysis of three families of bioactive lipid mediators leukotrienes, resolvins, protectins and related hydroxy-fatty acids by liquid chromatography/electrospray ionisation tandem mass spectrometry. Rapid Commun Mass Spectrom. 2008; 22(2):75-83.Rapid Commun Mass Spectrom2008-01-01T00:00:002008Simultaneous lipidomic analysis of three families of bioactive lipid mediators leukotrienes, resolvins, protectins and related hydroxy-fatty acids by liquid chromatography/electrospray ionisation tandem mass spectrometry.18673006Serhan CNJournal of periodontologyControlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators. J Periodontol. 2008 Aug; 79(8 Suppl):1520-6.J Periodontol2008-08-01T00:00:002008Controlling the resolution of acute inflammation: a new genus of dual anti-inflammatory and proresolving mediators.19050288Kasuga K, Yang R, Porter TF, Agrawal N, Petasis NA, Irimia D, Toner M, Serhan CNJournal of immunology (Baltimore, Md. : 1950)Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution. J Immunol. 2008 Dec 15; 181(12):8677-87.J Immunol2008-12-15T00:00:002008Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution.20130564Planagumà A, Pfeffer MA, Rubin G, Croze R, Uddin M, Serhan CN, Levy BDMucosal immunologyLovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4. Mucosal Immunol. 2010 May; 3(3):270-9.Mucosal Immunol2010-02-03T00:00:002010Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4.20709806Ho KJ, Spite M, Owens CD, Lancero H, Kroemer AH, Pande R, Creager MA, Serhan CN, Conte MSThe American journal of pathologyAspirin-triggered lipoxin and resolvin E1 modulate vascular smooth muscle phenotype and correlate with peripheral atherosclerosis. Am J Pathol. 2010 Oct; 177(4):2116-23.Am J Pathol2010-08-13T00:00:002010Aspirin-triggered lipoxin and resolvin E1 modulate vascular smooth muscle phenotype and correlate with peripheral atherosclerosis.20813960Serhan CNThe American journal of pathologyNovel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not? Am J Pathol. 2010 Oct; 177(4):1576-91.Am J Pathol2010-09-02T00:00:002010Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?23241890Gao L, Faibish D, Fredman G, Herrera BS, Chiang N, Serhan CN, Van Dyke TE, Gyurko RJournal of immunology (Baltimore, Md. : 1950)Resolvin E1 and chemokine-like receptor 1 mediate bone preservation. J Immunol. 2013 Jan 15; 190(2):689-94.J Immunol2012-12-14T00:00:002012Resolvin E1 and chemokine-like receptor 1 mediate bone preservation.3097008Serhan CN, Nicolaou KC, Webber SE, Veale CA, Dahlén SE, Puustinen TJ, Samuelsson BThe Journal of biological chemistryLipoxin A. Stereochemistry and biosynthesis. J Biol Chem. 1986 Dec 15; 261(35):16340-5.J Biol Chem1986-12-15T00:00:001986Lipoxin A. Stereochemistry and biosynthesis.Authorship 10161397428986437Bowden JA, Heckert A, Ulmer CZ, Jones CM, Koelmel JP, Abdullah L, Ahonen L, Alnouti Y, Armando AM, Asara JM, Bamba T, Barr JR, Bergquist J, Borchers CH, Brandsma J, Breitkopf SB, Cajka T, Cazenave-Gassiot A, Checa A, Cinel MA, Colas RA, Cremers S, Dennis EA, Evans JE, Fauland A, Fiehn O, Gardner MS, Garrett TJ, Gotlinger KH, Han J, Huang Y, Neo AH, Hyötyläinen T, Izumi Y, Jiang H, Jiang H, Jiang J, Kachman M, Kiyonami R, Klavins K, Klose C, Köfeler HC, Kolmert J, Koal T, Koster G, Kuklenyik Z, Kurland IJ, Leadley M, Lin K, Maddipati KR, McDougall D, Meikle PJ, Mellett NA, Monnin C, Moseley MA, Nandakumar R, Oresic M, Patterson R, Peake D, Pierce JS, Post M, Postle AD, Pugh R, Qiu Y, Quehenberger O, Ramrup P, Rees J, Rembiesa B, Reynaud D, Roth MR, Sales S, Schuhmann K, Schwartzman ML, Serhan CN, Shevchenko A, Somerville SE, St John-Williams L, Surma MA, Takeda H, Thakare R, Thompson JW, Torta F, Triebl A, Trötzmüller M, Ubhayasekera SJK, Vuckovic D, Weir JM, Welti R, Wenk MR, Wheelock CE, Yao L, Yuan M, Zhao XH, Zhou SJournal of lipid researchHarmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma. J Lipid Res. 2017 12; 58(12):2275-2288.J Lipid Res2017-10-06T00:00:002017Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.6291511Serhan CN, Radin A, Smolen JE, Korchak H, Samuelsson B, Weissmann GBiochemical and biophysical research communicationsLeukotriene B4 is a complete secretagogue in human neutrophils: a kinetic analysis. Biochem Biophys Res Commun. 1982 Aug; 107(3):1006-12.Biochem Biophys Res Commun1982-08-01T00:00:001982Leukotriene B4 is a complete secretagogue in human neutrophils: a kinetic analysis.6303442Serhan CN, Broekman MJ, Korchak HM, Smolen JE, Marcus AJ, Weissmann GBiochimica et biophysica actaChanges in phosphatidylinositol and phosphatidic acid in stimulated human neutrophils. Relationship to calcium mobilization, aggregation and superoxide radical generation. Biochim Biophys Acta. 1983 Jun 02; 762(3):420-8.Biochim Biophys Acta1983-06-02T00:00:001983Changes in phosphatidylinositol and phosphatidic acid in stimulated human neutrophils. Relationship to calcium mobilization, aggregation and superoxide radical generation.28993702Sima C, Montero E, Nguyen D, Freire M, Norris P, Serhan CN, Van Dyke TEScientific reportsERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance. Sci Rep. 2017 10 09; 7(1):12848.Sci Rep2017-10-09T00:00:002017ERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance.10673235Serhan CN, Takano T, Chiang N, Gronert K, Clish CBAmerican journal of respiratory and critical care medicineFormation of endogenous "antiinflammatory" lipid mediators by transcellular biosynthesis. Lipoxins and aspirin-triggered lipoxins inhibit neutrophil recruitment and vascular permeability. Am J Respir Crit Care Med. 2000 Feb; 161(2 Pt 2):S95-S101.Am J Respir Crit Care Med2000-02-01T00:00:002000Formation of endogenous "antiinflammatory" lipid mediators by transcellular biosynthesis. Lipoxins and aspirin-triggered lipoxins inhibit neutrophil recruitment and vascular permeability.10934235Serhan CN, Prescott SMThe Journal of experimental medicineThe scent of a phagocyte: Advances on leukotriene b(4) receptors. J Exp Med. 2000 Aug 07; 192(3):F5-8.J Exp Med2000-08-07T00:00:002000The scent of a phagocyte: Advances on leukotriene b(4) receptors.10943332Serhan CN, Levy BD, Clish CB, Gronert K, Chiang NErnst Schering Research Foundation workshopLipoxins, aspirin-triggered 15-epi-lipoxin stable analogs and their receptors in anti-inflammation: a window for therapeutic opportunity. Ernst Schering Res Found Workshop. 2000; (31):143-85.Ernst Schering Res Found Workshop2000-01-01T00:00:002000Lipoxins, aspirin-triggered 15-epi-lipoxin stable analogs and their receptors in anti-inflammation: a window for therapeutic opportunity.12417634Aliberti J, Serhan C, Sher AThe Journal of experimental medicineParasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection. J Exp Med. 2002 Nov 04; 196(9):1253-62.J Exp Med2002-11-04T00:00:002002Parasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection.14766977Vance RE, Hong S, Gronert K, Serhan CN, Mekalanos JJProceedings of the National Academy of Sciences of the United States of AmericaThe opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):2135-9.Proc Natl Acad Sci U S A2004-02-06T00:00:002004The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase.16099386Serhan CNProstaglandins & other lipid mediatorsMediator lipidomics. Prostaglandins Other Lipid Mediat. 2005 Sep; 77(1-4):4-14.Prostaglandins Other Lipid Mediat2004-11-28T00:00:002004Mediator lipidomics.16750421Schwab JM, Serhan CNCurrent opinion in pharmacologyLipoxins and new lipid mediators in the resolution of inflammation. Curr Opin Pharmacol. 2006 Aug; 6(4):414-20.Curr Opin Pharmacol2006-06-05T00:00:002006Lipoxins and new lipid mediators in the resolution of inflammation.2154229Luscinskas FW, Nicolaou KC, Webber SE, Veale CA, Gimbrone MA, Serhan CNBiochemical pharmacologyCa2+ mobilization with leukotriene A4 and epoxytetraenes in human neutrophils. Biochem Pharmacol. 1990 Jan 15; 39(2):355-65.Biochem Pharmacol1990-01-15T00:00:001990Ca2+ mobilization with leukotriene A4 and epoxytetraenes in human neutrophils.1617790Brezinski DA, Nesto RW, Serhan CNCirculationAngioplasty triggers intracoronary leukotrienes and lipoxin A4. Impact of aspirin therapy. Circulation. 1992 Jul; 86(1):56-63.Circulation1992-07-01T00:00:001992Angioplasty triggers intracoronary leukotrienes and lipoxin A4. Impact of aspirin therapy.1632770Roll FJ, Perez HD, Serhan CNBiochemical and biophysical research communicationsCharacterization of a novel arachidonic acid-derived neutrophil chemoattractant. Biochem Biophys Res Commun. 1992 Jul 15; 186(1):269-76.Biochem Biophys Res Commun1992-07-15T00:00:001992Characterization of a novel arachidonic acid-derived neutrophil chemoattractant.1818493Brady HR, Denton MD, Brenner BM, Serhan CNAdvances in experimental medicine and biologyNeutrophil adhesion to glomerular mesangial cells: regulation by lipoxygenase-derived eicosanoids. Adv Exp Med Biol. 1991; 314:347-59.Adv Exp Med Biol1991-01-01T00:00:001991Neutrophil adhesion to glomerular mesangial cells: regulation by lipoxygenase-derived eicosanoids.15061569Serhan CN, Chiang NRheumatic diseases clinics of North AmericaNovel endogenous small molecules as the checkpoint controllers in inflammation and resolution: entrée for resoleomics. Rheum Dis Clin North Am. 2004 Feb; 30(1):69-95.Rheum Dis Clin North Am2004-02-01T00:00:002004Novel endogenous small molecules as the checkpoint controllers in inflammation and resolution: entrée for resoleomics.Authorship 1019704617056514Duffield JS, Hong S, Vaidya VS, Lu Y, Fredman G, Serhan CN, Bonventre JVJournal of immunology (Baltimore, Md. : 1950)Resolvin D series and protectin D1 mitigate acute kidney injury. J Immunol. 2006 Nov 01; 177(9):5902-11.J Immunol2006-11-01T00:00:002006Resolvin D series and protectin D1 mitigate acute kidney injury.2169183Serhan CN, Sheppard KA, Fiore SAdvances in prostaglandin, thromboxane, and leukotriene researchLipoxin formation: evaluation of the role and actions of leukotriene A4. Adv Prostaglandin Thromboxane Leukot Res. 1990; 20:54-62.Adv Prostaglandin Thromboxane Leukot Res1990-01-01T00:00:001990Lipoxin formation: evaluation of the role and actions of leukotriene A4.17267386Serhan CN, Brain SD, Buckley CD, Gilroy DW, Haslett C, O'Neill LA, Perretti M, Rossi AG, Wallace JLFASEB journal : official publication of the Federation of American Societies for Experimental BiologyResolution of inflammation: state of the art, definitions and terms. FASEB J. 2007 Feb; 21(2):325-32.FASEB J2007-02-01T00:00:002007Resolution of inflammation: state of the art, definitions and terms.19483113El Kebir D, József L, Pan W, Wang L, Petasis NA, Serhan CN, Filep JGAmerican journal of respiratory and critical care medicine15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury. Am J Respir Crit Care Med. 2009 Aug 15; 180(4):311-9.Am J Respir Crit Care Med2009-05-29T00:00:00200915-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury.2539113Fiore S, Serhan CNBiochemical and biophysical research communicationsPhospholipid bilayers enhance the stability of leukotriene A4 and epoxytetraenes: stabilization of eicosanoids by liposomes. Biochem Biophys Res Commun. 1989 Mar 15; 159(2):477-81.Biochem Biophys Res Commun1989-03-15T00:00:001989Phospholipid bilayers enhance the stability of leukotriene A4 and epoxytetraenes: stabilization of eicosanoids by liposomes.Authorship 10208477Authorship 1021846727394692Sorokin AV, Yang ZH, Vaisman BL, Thacker S, Yu ZX, Sampson M, Serhan CN, Remaley ATThe Journal of nutritional biochemistryAddition of aspirin to a fish oil-rich diet decreases inflammation and atherosclerosis in ApoE-null mice. J Nutr Biochem. 2016 09; 35:58-65.J Nutr Biochem2016-06-19T00:00:002016Addition of aspirin to a fish oil-rich diet decreases inflammation and atherosclerosis in ApoE-null mice.29057147Reátegui E, Jalali F, Khankhel AH, Wong E, Cho H, Lee J, Serhan CN, Dalli J, Elliott H, Irimia DNature biomedical engineeringMicroscale arrays for the profiling of start and stop signals coordinating human-neutrophil swarming. Nat Biomed Eng. 2017; 1.Nat Biomed Eng2017-06-30T00:00:002017Microscale arrays for the profiling of start and stop signals coordinating human-neutrophil swarming.17982093Hasturk H, Kantarci A, Goguet-Surmenian E, Blackwood A, Andry C, Serhan CN, Van Dyke TEJournal of immunology (Baltimore, Md. : 1950)Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. J Immunol. 2007 Nov 15; 179(10):7021-9.J Immunol2007-11-15T00:00:002007Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo.21757729Yang R, Fredman G, Krishnamoorthy S, Agrawal N, Irimia D, Piomelli D, Serhan CNThe Journal of biological chemistryDecoding functional metabolomics with docosahexaenoyl ethanolamide (DHEA) identifies novel bioactive signals. J Biol Chem. 2011 Sep 09; 286(36):31532-41.J Biol Chem2011-07-12T00:00:002011Decoding functional metabolomics with docosahexaenoyl ethanolamide (DHEA) identifies novel bioactive signals.22016541Park CK, Lü N, Xu ZZ, Liu T, Serhan CN, Ji RRThe Journal of neuroscience : the official journal of the Society for NeuroscienceResolving TRPV1- and TNF-a-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. J Neurosci. 2011 Oct 19; 31(42):15072-85.J Neurosci2011-10-19T00:00:002011Resolving TRPV1- and TNF-a-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1.14580368Schwab JM, Schluesener HJ, Meyermann R, Serhan CNProstaglandins, leukotrienes, and essential fatty acidsCOX-3 the enzyme and the concept: steps towards highly specialized pathways and precision therapeutics? Prostaglandins Leukot Essent Fatty Acids. 2003 Nov; 69(5):339-43.Prostaglandins Leukot Essent Fatty Acids2003-11-01T00:00:002003COX-3 the enzyme and the concept: steps towards highly specialized pathways and precision therapeutics?1825527Serhan CN, Brezinski MEAdvances in prostaglandin, thromboxane, and leukotriene researchSelective incorporation of 15-HETE in phosphatidylinositol: agonist-induced deacylation and transformation of stored HETEs by human neutrophils. Adv Prostaglandin Thromboxane Leukot Res. 1991; 21A:105-8.Adv Prostaglandin Thromboxane Leukot Res1991-01-01T00:00:001991Selective incorporation of 15-HETE in phosphatidylinositol: agonist-induced deacylation and transformation of stored HETEs by human neutrophils.14762043Pasche B, Serhan CNJAMAIs C-reactive protein an inflammation opsonin that signals colon cancer risk? JAMA. 2004 Feb 04; 291(5):623-4.JAMA2004-02-04T00:00:002004Is C-reactive protein an inflammation opsonin that signals colon cancer risk?14970178Bannenberg GL, Aliberti J, Hong S, Sher A, Serhan CThe Journal of experimental medicineExogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis. J Exp Med. 2004 Feb 16; 199(4):515-23.J Exp Med2004-02-16T00:00:002004Exogenous pathogen and plant 15-lipoxygenase initiate endogenous lipoxin A4 biosynthesis.Authorship 1024384429110146Hamilton JA, Hasturk H, Kantarci A, Serhan CN, Van Dyke TCurrent atherosclerosis reportsAtherosclerosis, Periodontal Disease, and Treatment with Resolvins. Curr Atheroscler Rep. 2017 Nov 06; 19(12):57.Curr Atheroscler Rep2017-11-06T00:00:002017Atherosclerosis, Periodontal Disease, and Treatment with Resolvins.11413151Serhan CN, Oliw EThe Journal of clinical investigationUnorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways. J Clin Invest. 2001 Jun; 107(12):1481-9.J Clin Invest2001-06-01T00:00:002001Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways.18249111Petasis NA, Keledjian R, Sun YP, Nagulapalli KC, Tjonahen E, Yang R, Serhan CNBioorganic & medicinal chemistry lettersDesign and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties. Bioorg Med Chem Lett. 2008 Feb 15; 18(4):1382-7.Bioorg Med Chem Lett2008-01-09T00:00:002008Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties.8777573Serhan CN, Romano MJournal of lipid mediators and cell signallingLipoxin biosynthesis and actions: role of the human platelet LX-synthase. J Lipid Mediat Cell Signal. 1995 Oct; 12(2-3):293-306.J Lipid Mediat Cell Signal1995-10-01T00:00:001995Lipoxin biosynthesis and actions: role of the human platelet LX-synthase.6422933Serhan CN, Hamberg M, Samuelsson BBiochemical and biophysical research communicationsTrihydroxytetraenes: a novel series of compounds formed from arachidonic acid in human leukocytes. Biochem Biophys Res Commun. 1984 Feb 14; 118(3):943-9.Biochem Biophys Res Commun1984-02-14T00:00:001984Trihydroxytetraenes: a novel series of compounds formed from arachidonic acid in human leukocytes.6807175Weissmann G, Serhan C, Korchak HM, Smolen JEAnnals of the New York Academy of SciencesNeutrophils: release of mediators of inflammation with special reference to rheumatoid arthritis. Ann N Y Acad Sci. 1982; 389:11-24.Ann N Y Acad Sci1982-01-01T00:00:001982Neutrophils: release of mediators of inflammation with special reference to rheumatoid arthritis.7519397McManus M, Serhan C, Jackson P, Strange KThe American journal of physiologyKetoconazole blocks organic osmolyte efflux independently of its effect on arachidonic acid conversion. Am J Physiol. 1994 Jul; 267(1 Pt 1):C266-71.Am J Physiol1994-07-01T00:00:001994Ketoconazole blocks organic osmolyte efflux independently of its effect on arachidonic acid conversion.12562878Van Dyke TE, Serhan CNJournal of dental researchResolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases. J Dent Res. 2003 Feb; 82(2):82-90.J Dent Res2003-02-01T00:00:002003Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases.1883860Brezinski DA, Serhan CNBiological mass spectrometryCharacterization of lipoxins by combined gas chromatography and electron-capture negative ion chemical ionization mass spectrometry: formation of lipoxin A4 by stimulated human whole blood. Biol Mass Spectrom. 1991 Feb; 20(2):45-52.Biol Mass Spectrom1991-02-01T00:00:001991Characterization of lipoxins by combined gas chromatography and electron-capture negative ion chemical ionization mass spectrometry: formation of lipoxin A4 by stimulated human whole blood.15302682Bannenberg G, Moussignac RL, Gronert K, Devchand PR, Schmidt BA, Guilford WJ, Bauman JG, Subramanyam B, Perez HD, Parkinson JF, Serhan CNBritish journal of pharmacologyLipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration. Br J Pharmacol. 2004 Sep; 143(1):43-52.Br J Pharmacol2004-08-09T00:00:002004Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration.15322859Serhan CNHistochemistry and cell biologyA search for endogenous mechanisms of anti-inflammation uncovers novel chemical mediators: missing links to resolution. Histochem Cell Biol. 2004 Oct; 122(4):305-21.Histochem Cell Biol2004-08-21T00:00:002004A search for endogenous mechanisms of anti-inflammation uncovers novel chemical mediators: missing links to resolution.Authorship 10283092Authorship 1027873229163481Dalli J, Serhan CNFrontiers in immunologyPro-Resolving Mediators in Regulating and Conferring Macrophage Function. Front Immunol. 2017; 8:1400.Front Immunol2017-11-01T00:00:002017Pro-Resolving Mediators in Regulating and Conferring Macrophage Function.29154174Dalli J, Serhan CNCurrent opinion in immunologyImmunoresolvents signaling molecules at intersection between the brain and immune system. Curr Opin Immunol. 2018 02; 50:48-54.Curr Opin Immunol2017-11-16T00:00:002017Immunoresolvents signaling molecules at intersection between the brain and immune system.21867913Serhan CN, Fredman G, Yang R, Karamnov S, Belayev LS, Bazan NG, Zhu M, Winkler JW, Petasis NAChemistry & biologyNovel proresolving aspirin-triggered DHA pathway. Chem Biol. 2011 Aug 26; 18(8):976-87.Chem Biol2011-08-26T00:00:002011Novel proresolving aspirin-triggered DHA pathway.8518275Serhan CN, Fiore S, Brezinski DA, Lynch SBiochemistryLipoxin A4 metabolism by differentiated HL-60 cells and human monocytes: conversion to novel 15-oxo and dihydro products. Biochemistry. 1993 Jun 29; 32(25):6313-9.Biochemistry1993-06-29T00:00:001993Lipoxin A4 metabolism by differentiated HL-60 cells and human monocytes: conversion to novel 15-oxo and dihydro products.Authorship 1029474229191914Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR, Schmidt B, Dalli J, Greene ER, Gus-Brautbar Y, Piwowarski J, Mammoto T, Zurakowski D, Perretti M, Sukhatme VP, Kaipainen A, Kieran MW, Huang S, Panigrahy DThe Journal of experimental medicineResolvins suppress tumor growth and enhance cancer therapy. J Exp Med. 2018 01 02; 215(1):115-140.J Exp Med2017-11-30T00:00:002017Resolvins suppress tumor growth and enhance cancer therapy.22253477Serhan CN, Dalli J, Karamnov S, Choi A, Park CK, Xu ZZ, Ji RR, Zhu M, Petasis NAFASEB journal : official publication of the Federation of American Societies for Experimental BiologyMacrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. FASEB J. 2012 Apr; 26(4):1755-65.FASEB J2012-01-17T00:00:002012Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain.22308341Kanter JE, Kramer F, Barnhart S, Averill MM, Vivekanandan-Giri A, Vickery T, Li LO, Becker L, Yuan W, Chait A, Braun KR, Potter-Perigo S, Sanda S, Wight TN, Pennathur S, Serhan CN, Heinecke JW, Coleman RA, Bornfeldt KEProceedings of the National Academy of Sciences of the United States of AmericaDiabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):E715-24.Proc Natl Acad Sci U S A2012-01-17T00:00:002012Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1.16796379Serhan CN, Hong S, Lu YThe AAPS journalLipid mediator informatics-lipidomics: novel pathways in mapping resolution. AAPS J. 2006 Apr 28; 8(2):E284-97.AAPS J2006-04-28T00:00:002006Lipid mediator informatics-lipidomics: novel pathways in mapping resolution.2155608Fiore S, Nicolaou KC, Caulfield T, Kataoka H, Serhan CNThe Biochemical journalEvaluation of synthetic sphingosine, lysosphingolipids and glycosphingolipids as inhibitors of functional responses of human neutrophils. Biochem J. 1990 Feb 15; 266(1):25-31.Biochem J1990-02-15T00:00:001990Evaluation of synthetic sphingosine, lysosphingolipids and glycosphingolipids as inhibitors of functional responses of human neutrophils.2173421Brady HR, Persson U, Ballermann BJ, Brenner BM, Serhan CNThe American journal of physiologyLeukotrienes stimulate neutrophil adhesion to mesangial cells: modulation with lipoxins. Am J Physiol. 1990 Nov; 259(5 Pt 2):F809-15.Am J Physiol1990-11-01T00:00:001990Leukotrienes stimulate neutrophil adhesion to mesangial cells: modulation with lipoxins.17337246Ariel A, Serhan CNTrends in immunologyResolvins and protectins in the termination program of acute inflammation. Trends Immunol. 2007 Apr; 28(4):176-83.Trends Immunol2007-03-06T00:00:002007Resolvins and protectins in the termination program of acute inflammation.17579083El Kebir D, József L, Khreiss T, Pan W, Petasis NA, Serhan CN, Filep JGJournal of immunology (Baltimore, Md. : 1950)Aspirin-triggered lipoxins override the apoptosis-delaying action of serum amyloid A in human neutrophils: a novel mechanism for resolution of inflammation. J Immunol. 2007 Jul 01; 179(1):616-22.J Immunol2007-07-01T00:00:002007Aspirin-triggered lipoxins override the apoptosis-delaying action of serum amyloid A in human neutrophils: a novel mechanism for resolution of inflammation.23484005Hsiao HM, Sapinoro RE, Thatcher TH, Croasdell A, Levy EP, Fulton RA, Olsen KC, Pollock SJ, Serhan CN, Phipps RP, Sime PJPloS oneA novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation. PLoS One. 2013; 8(3):e58258.PLoS One2013-03-06T00:00:002013A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation.6092359Radmark O, Serhan C, Hamberg M, Lundberg U, Ennis MD, Bundy GL, Oglesby TD, Aristoff PA, Harrison AW, Slomp GThe Journal of biological chemistryStereochemistry, total synthesis, and biological activity of 14,15-dihydroxy-5,8,10,12-eicosatetraenoic acid. J Biol Chem. 1984 Nov 10; 259(21):13011-6.J Biol Chem1984-11-10T00:00:001984Stereochemistry, total synthesis, and biological activity of 14,15-dihydroxy-5,8,10,12-eicosatetraenoic acid.6769114Weissmann G, Anderson P, Serhan C, Samuelsson E, Goodman EProceedings of the National Academy of Sciences of the United States of AmericaA general method, employing arsenazo III in liposomes, for study of calcium ionophores: results with A23187 and prostaglandins. Proc Natl Acad Sci U S A. 1980 Mar; 77(3):1506-10.Proc Natl Acad Sci U S A1980-03-01T00:00:001980A general method, employing arsenazo III in liposomes, for study of calcium ionophores: results with A23187 and prostaglandins.7568157Clària J, Serhan CNProceedings of the National Academy of Sciences of the United States of AmericaAspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9475-9.Proc Natl Acad Sci U S A1995-10-10T00:00:001995Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions.8121246Levy BD, Bertram S, Tai HH, Israel E, Fischer A, Drazen JM, Serhan CNLipidsAgonist-induced lipoxin A4 generation: detection by a novel lipoxin A4-ELISA. Lipids. 1993 Dec; 28(12):1047-53.Lipids1993-12-01T00:00:001993Agonist-induced lipoxin A4 generation: detection by a novel lipoxin A4-ELISA.8305432Rowley AF, Lloyd-Evans P, Barrow SE, Serhan CNBiochemistryLipoxin biosynthesis by trout macrophages involves the formation of epoxide intermediates. Biochemistry. 1994 Feb 01; 33(4):856-63.Biochemistry1994-02-01T00:00:001994Lipoxin biosynthesis by trout macrophages involves the formation of epoxide intermediates.8445282Serhan CNThe Journal of laboratory and clinical medicineCell-cell interactions in the generation of eicosanoids: charting the routes and products of transcellular biosynthesis. J Lab Clin Med. 1993 Mar; 121(3):372-4.J Lab Clin Med1993-03-01T00:00:001993Cell-cell interactions in the generation of eicosanoids: charting the routes and products of transcellular biosynthesis.22844113Clària J, Dalli J, Yacoubian S, Gao F, Serhan CNJournal of immunology (Baltimore, Md. : 1950)Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat. J Immunol. 2012 Sep 01; 189(5):2597-605.J Immunol2012-07-27T00:00:002012Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat.22974760Gil-Villa AM, Norling LV, Serhan CN, Cordero D, Rojas M, Cadavid AProstaglandins, leukotrienes, and essential fatty acidsAspirin triggered-lipoxin A4 reduces the adhesion of human polymorphonuclear neutrophils to endothelial cells initiated by preeclamptic plasma. Prostaglandins Leukot Essent Fatty Acids. 2012 Oct-Nov; 87(4-5):127-34.Prostaglandins Leukot Essent Fatty Acids2012-09-10T00:00:002012Aspirin triggered-lipoxin A4 reduces the adhesion of human polymorphonuclear neutrophils to endothelial cells initiated by preeclamptic plasma.Authorship 10324821129238967Motwani MP, Bennett F, Norris PC, Maini AA, George MJ, Newson J, Henderson A, Hobbs AJ, Tepper M, White B, Serhan CN, MacAllister R, Gilroy DWClinical pharmacology and therapeuticsPotent Anti-Inflammatory and Pro-Resolving Effects of Anabasum in a Human Model of Self-Resolving Acute Inflammation. Clin Pharmacol Ther. 2018 10; 104(4):675-686.Clin Pharmacol Ther2018-01-30T00:00:002018Potent Anti-Inflammatory and Pro-Resolving Effects of Anabasum in a Human Model of Self-Resolving Acute Inflammation.19853429Sun YP, Tjonahen E, Keledjian R, Zhu M, Yang R, Recchiuti A, Pillai PS, Petasis NA, Serhan CNProstaglandins, leukotrienes, and essential fatty acidsAnti-inflammatory and pro-resolving properties of benzo-lipoxin A(4) analogs. Prostaglandins Leukot Essent Fatty Acids. 2009 Nov-Dec; 81(5-6):357-66.Prostaglandins Leukot Essent Fatty Acids2009-10-22T00:00:002009Anti-inflammatory and pro-resolving properties of benzo-lipoxin A(4) analogs.20382842Bazan NG, Calandria JM, Serhan CNJournal of lipid researchRescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1. J Lipid Res. 2010 Aug; 51(8):2018-31.J Lipid Res2010-04-09T00:00:002010Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1.21766791Serhan CN, Petasis NAChemical reviewsResolvins and protectins in inflammation resolution. Chem Rev. 2011 Oct 12; 111(10):5922-43.Chem Rev2011-07-18T00:00:002011Resolvins and protectins in inflammation resolution.21771892Bäck M, Dahlén SE, Drazen JM, Evans JF, Serhan CN, Shimizu T, Yokomizo T, Rovati GEPharmacological reviewsInternational Union of Basic and Clinical Pharmacology. LXXXIV: leukotriene receptor nomenclature, distribution, and pathophysiological functions. Pharmacol Rev. 2011 Sep; 63(3):539-84.Pharmacol Rev2011-09-01T00:00:002011International Union of Basic and Clinical Pharmacology. LXXXIV: leukotriene receptor nomenclature, distribution, and pathophysiological functions.2418494Patarroyo M, Beatty PG, Serhan CN, Gahmberg CGScandinavian journal of immunologyIdentification of a cell-surface glycoprotein mediating adhesion in human granulocytes. Scand J Immunol. 1985 Dec; 22(6):619-31.Scand J Immunol1985-12-01T00:00:001985Identification of a cell-surface glycoprotein mediating adhesion in human granulocytes.2418836Hansson A, Serhan CN, Haeggström J, Ingelman-Sundberg M, Samuelsson BBiochemical and biophysical research communicationsActivation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid. Biochem Biophys Res Commun. 1986 Feb 13; 134(3):1215-22.Biochem Biophys Res Commun1986-02-13T00:00:001986Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid.2526454Serhan CNAdvances in prostaglandin, thromboxane, and leukotriene researchOn the generation of lipoxins and novel related compounds by human neutrophils: relationship to leukotriene production. Adv Prostaglandin Thromboxane Leukot Res. 1989; 19:116-21.Adv Prostaglandin Thromboxane Leukot Res1989-01-01T00:00:001989On the generation of lipoxins and novel related compounds by human neutrophils: relationship to leukotriene production.19630766Serhan CNJournal of thrombosis and haemostasis : JTHSystems approach to inflammation resolution: identification of novel anti-inflammatory and pro-resolving mediators. J Thromb Haemost. 2009 Jul; 7 Suppl 1:44-8.J Thromb Haemost2009-07-01T00:00:002009Systems approach to inflammation resolution: identification of novel anti-inflammatory and pro-resolving mediators.2555280Stern A, Serhan CNFree radical research communicationsHuman red cells enhance the formation of 5-lipoxygenase-derived products by neutrophils. Free Radic Res Commun. 1989; 7(3-6):335-9.Free Radic Res Commun1989-01-01T00:00:001989Human red cells enhance the formation of 5-lipoxygenase-derived products by neutrophils.2711954Dahlén SE, Veale CA, Webber SE, Marron BE, Nicolaou KC, Serhan CNAgents and actionsPharmacodynamics of lipoxin A4 in airway smooth muscle. Agents Actions. 1989 Jan; 26(1-2):93-5.Agents Actions1989-01-01T00:00:001989Pharmacodynamics of lipoxin A4 in airway smooth muscle.29302056Werz O, Gerstmeier J, Libreros S, De la Rosa X, Werner M, Norris PC, Chiang N, Serhan CNNature communicationsHuman macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity. Nat Commun. 2018 01 04; 9(1):59.Nat Commun2018-01-04T00:00:002018Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity.Authorship 103630383107549Lam BK, Serhan CN, Samuelsson B, Wong PYBiochemical and biophysical research communicationsA phospholipase A2 isoenzyme provokes lipoxin B formation from endogenous sources of arachidonic acid in porcine leukocytes. Biochem Biophys Res Commun. 1987 Apr 14; 144(1):123-31.Biochem Biophys Res Commun1987-04-14T00:00:001987A phospholipase A2 isoenzyme provokes lipoxin B formation from endogenous sources of arachidonic acid in porcine leukocytes.6283845Weissmann G, Serhan C, Smolen JE, Korchak HM, Friedman R, Kaplan HBAdvances in prostaglandin, thromboxane, and leukotriene researchStimulus-secretion coupling in the human neutrophil: the role of phosphatidic acid and oxidized fatty acids in the translocation of calcium. Adv Prostaglandin Thromboxane Leukot Res. 1982; 9:259-72.Adv Prostaglandin Thromboxane Leukot Res1982-01-01T00:00:001982Stimulus-secretion coupling in the human neutrophil: the role of phosphatidic acid and oxidized fatty acids in the translocation of calcium.6698199Serhan CN, Lundberg U, Lindgren JA, Weissmann G, Samuelsson BFEBS lettersFormation of leukotriene C4 by human leukocytes exposed to monosodium urate crystals. FEBS Lett. 1984 Feb 13; 167(1):109-12.FEBS Lett1984-02-13T00:00:001984Formation of leukotriene C4 by human leukocytes exposed to monosodium urate crystals.20080636Krishnamoorthy S, Recchiuti A, Chiang N, Yacoubian S, Lee CH, Yang R, Petasis NA, Serhan CNProceedings of the National Academy of Sciences of the United States of AmericaResolvin D1 binds human phagocytes with evidence for proresolving receptors. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1660-5.Proc Natl Acad Sci U S A2010-01-04T00:00:002010Resolvin D1 binds human phagocytes with evidence for proresolving receptors.20708099Bannenberg G, Serhan CNBiochimica et biophysica actaSpecialized pro-resolving lipid mediators in the inflammatory response: An update. 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Prostaglandins. 1984 Apr; 27(4):563-81.Prostaglandins1984-04-01T00:00:001984Formation of leukotrienes and hydroxy acids by human neutrophils and platelets exposed to monosodium urate.7344228Weissmann G, Serhan C, Korchak HM, Smolen JE, Broekman MJ, Marcus AJTransactions of the Association of American PhysiciansNeutrophils generate phosphatidic acid, an "endogenous calcium ionophore" before releasing mediators of inflammation. Trans Assoc Am Physicians. 1981; 94:357-65.Trans Assoc Am Physicians1981-01-01T00:00:001981Neutrophils generate phosphatidic acid, an "endogenous calcium ionophore" before releasing mediators of inflammation.7972271Sri Kantha S, Matsumura H, Kubo E, Kawase K, Takahata R, Serhan CN, Hayaishi OProstaglandins, leukotrienes, and essential fatty acidsEffects of prostaglandin D2, lipoxins and leukotrienes on sleep and brain temperature of rats. Prostaglandins Leukot Essent Fatty Acids. 1994 Aug; 51(2):87-93.Prostaglandins Leukot Essent Fatty Acids1994-08-01T00:00:001994Effects of prostaglandin D2, lipoxins and leukotrienes on sleep and brain temperature of rats.19865173Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M, Serhan CNNatureResolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature. 2009 Oct 29; 461(7268):1287-91.Nature2009-10-29T00:00:002009Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis.2936084Serhan CN, Fahlstadius P, Dahlén SE, Hamberg M, Samuelsson BAdvances in prostaglandin, thromboxane, and leukotriene researchBiosynthesis and biological activities of lipoxins. Adv Prostaglandin Thromboxane Leukot Res. 1985; 15:163-6.Adv Prostaglandin Thromboxane Leukot Res1985-01-01T00:00:001985Biosynthesis and biological activities of lipoxins.8898374Clària J, Lee MH, Serhan CNMolecular medicine (Cambridge, Mass.)Aspirin-triggered lipoxins (15-epi-LX) are generated by the human lung adenocarcinoma cell line (A549)-neutrophil interactions and are potent inhibitors of cell proliferation. Mol Med. 1996 Sep; 2(5):583-96.Mol Med1996-09-01T00:00:001996Aspirin-triggered lipoxins (15-epi-LX) are generated by the human lung adenocarcinoma cell line (A549)-neutrophil interactions and are potent inhibitors of cell proliferation.9077519Serhan CN, Drazen JMThe Journal of clinical investigationAntiinflammatory potential of lipoxygenase-derived eicosanoids: a molecular switch at 5 and 15 positions? J Clin Invest. 1997 Mar 15; 99(6):1147-8.J Clin Invest1997-03-15T00:00:001997Antiinflammatory potential of lipoxygenase-derived eicosanoids: a molecular switch at 5 and 15 positions?Authorship 104395711Authorship 10592410992546Serhan CN, Clish CBThoraxAspirin triggered lipid mediators: novel inhibitors of leucocyte trafficking. Thorax. 2000 Oct; 55 Suppl 2:S10-2.Thorax2000-10-01T00:00:002000Aspirin triggered lipid mediators: novel inhibitors of leucocyte trafficking.1825377Fiore S, Nigam S, Serhan CNAdvances in prostaglandin, thromboxane, and leukotriene researchLipoxins trigger the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion. Adv Prostaglandin Thromboxane Leukot Res. 1991; 21B:553-6.Adv Prostaglandin Thromboxane Leukot Res1991-01-01T00:00:001991Lipoxins trigger the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion.15265945Ohira T, Bannenberg G, Arita M, Takahashi M, Ge Q, Van Dyke TE, Stahl GL, Serhan CN, Badwey JAJournal of immunology (Baltimore, Md. : 1950)A stable aspirin-triggered lipoxin A4 analog blocks phosphorylation of leukocyte-specific protein 1 in human neutrophils. J Immunol. 2004 Aug 01; 173(3):2091-8.J Immunol2004-08-01T00:00:002004A stable aspirin-triggered lipoxin A4 analog blocks phosphorylation of leukocyte-specific protein 1 in human neutrophils.15320881Andersson P, Serhan CN, Petasis NA, Palmblad JScandinavian journal of immunologyInteractions between lipoxin A4, the stable analogue 16-phenoxy-lipoxin A4 and leukotriene B4 in cytokine generation by human monocytes. 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FASEB J. 2005 Feb; 19(2):203-10.FASEB J2005-02-01T00:00:002005A synthetic eicosanoid LX-mimetic unravels host-donor interactions in allogeneic BMT-induced GvHD to reveal an early protective role for host neutrophils.9466977Takano T, Clish CB, Gronert K, Petasis N, Serhan CNThe Journal of clinical investigationNeutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues. J Clin Invest. 1998 Feb 15; 101(4):819-26.J Clin Invest1998-02-15T00:00:001998Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues.16216871Ariel A, Li PL, Wang W, Tang WX, Fredman G, Hong S, Gotlinger KH, Serhan CNThe Journal of biological chemistryThe docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering. J Biol Chem. 2005 Dec 30; 280(52):43079-86.J Biol Chem2005-10-10T00:00:002005The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering.16415877Machado FS, Johndrow JE, Esper L, Dias A, Bafica A, Serhan CN, Aliberti JNature medicineAnti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent. Nat Med. 2006 Mar; 12(3):330-4.Nat Med2006-01-15T00:00:002006Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent.16927933Serhan CNAnesthesiology clinicsNovel chemical mediators in the resolution of inflammation: resolvins and protectins. 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Proc Natl Acad Sci U S A. 1985 Feb; 82(4):1232-6.Proc Natl Acad Sci U S A1985-02-01T00:00:001985Circulating hydroxy fatty acids in familial Mediterranean fever.29490167Chiang N, Riley IR, Dalli J, Rodriguez AR, Spur BW, Serhan CNFASEB journal : official publication of the Federation of American Societies for Experimental BiologyNew maresin conjugates in tissue regeneration pathway counters leukotriene D4-stimulated vascular responses. FASEB J. 2018 07; 32(7):4043-4052.FASEB J2018-02-28T00:00:002018New maresin conjugates in tissue regeneration pathway counters leukotriene D4-stimulated vascular responses.10818443Levy BD, Serhan CNAnnals of the New York Academy of SciencesA novel polyisoprenyl phosphate signaling cascade in human neutrophils. Ann N Y Acad Sci. 2000 Apr; 905:69-80.Ann N Y Acad Sci2000-04-01T00:00:002000A novel polyisoprenyl phosphate signaling cascade in human neutrophils.10837478Clish CB, Levy BD, Chiang N, Tai HH, Serhan CNThe Journal of biological chemistryOxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation. J Biol Chem. 2000 Aug 18; 275(33):25372-80.J Biol Chem2000-08-18T00:00:002000Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation.11415929Serhan CN, Devchand PRAmerican journal of respiratory cell and molecular biologyNovel antiinflammatory targets for asthma. A role for PPARgamma? Am J Respir Cell Mol Biol. 2001 Jun; 24(6):658-61.Am J Respir Cell Mol Biol2001-06-01T00:00:002001Novel antiinflammatory targets for asthma. 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