Duraisingh, Manoj
completed student projects: Genetic analysis of how Duffy antigen expression level affects erythrocyte susceptibility to vivax malaria infection
eCommons Login: MD47
first name: Manoj
last name: Duraisingh
coauthor of: Paul, Aditya
coauthor of: Cowman, Alan
coauthor of: Tennessen, Jacob
coauthor of: Dass, Sheena
coauthor of: Dvorin, Jeffrey
full name: Manoj T. Duraisingh, Ph.D.
has faculty rank: Full Professor
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photo: https://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 60621
person in primary position: John LaPorte Given Professor of Immunology and Infectious Diseases
similar to: Cowman, Alan
similar to: Wirth, Dyann
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similar to: Neafsey, Daniel
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selected publications: Authorship 1783043
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selected publications: Authorship 1192478

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Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum.
PubMed Identifier: 10844681
author list: Duraisingh MT, Roper C, Walliker D, Warhurst DC
published in: Molecular microbiology
information resource reference: Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum. Mol Microbiol. 2000 May; 36(4):955-61.
journal title abbreviation: Mol Microbiol
publication date: 2000-05-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand.
PubMed Identifier: 10582887
author list: Price RN, Cassar C, Brockman A, Duraisingh M, van Vugt M, White NJ, Nosten F, Krishna S
published in: Antimicrobial agents and chemotherapy
information resource reference: The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand. Antimicrob Agents Chemother. 1999 Dec; 43(12):2943-9.
journal title abbreviation: Antimicrob Agents Chemother
publication date: 1999-12-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Resistance to antiparasitic drugs: the role of molecular diagnosis.
PubMed Identifier: 11943235
author list: Sangster N, Batterham P, Chapman HD, Duraisingh M, Le Jambre L, Shirley M, Upcroft J, Upcroft P
published in: International journal for parasitology
information resource reference: Resistance to antiparasitic drugs: the role of molecular diagnosis. Int J Parasitol. 2002 May; 32(5):637-53.
journal title abbreviation: Int J Parasitol
publication date: 2002-05-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Evidence for selection for the tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum by chloroquine and amodiaquine.
PubMed Identifier: 9075340
author list: Duraisingh MT, Drakeley CJ, Muller O, Bailey R, Snounou G, Targett GA, Greenwood BM, Warhurst DC
published in: Parasitology
information resource reference: Evidence for selection for the tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum by chloroquine and amodiaquine. Parasitology. 1997 Mar; 114 ( Pt 3):205-11.
journal title abbreviation: Parasitology
publication date: 1997-03-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Polymorphisms in the dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) genes of Plasmodium falciparum and in vivo resistance to sulphadoxine/pyrimethamine in isolates from Tanzania.
PubMed Identifier: 9735930
author list: Jelinek T, Rønn AM, Lemnge MM, Curtis J, Mhina J, Duraisingh MT, Bygbjerg IC, Warhurst DC
published in: Tropical medicine & international health : TM & IH
information resource reference: Polymorphisms in the dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) genes of Plasmodium falciparum and in vivo resistance to sulphadoxine/pyrimethamine in isolates from Tanzania. Trop Med Int Health. 1998 Aug; 3(8):605-9.
journal title abbreviation: Trop Med Int Health
publication date: 1998-08-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination.
PubMed Identifier: 11796125
author list: Duraisingh MT, Triglia T, Cowman AF
published in: International journal for parasitology
information resource reference: Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination. Int J Parasitol. 2002 Jan; 32(1):81-9.
journal title abbreviation: Int J Parasitol
publication date: 2002-01-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

The effect of Plasmodium falciparum Sir2a histone deacetylase on clonal and longitudinal variation in expression of the var family of virulence genes.
PubMed Identifier: 19666023
author list: Merrick CJ, Dzikowski R, Imamura H, Chuang J, Deitsch K, Duraisingh MT
published in: International journal for parasitology
information resource reference: The effect of Plasmodium falciparum Sir2a histone deacetylase on clonal and longitudinal variation in expression of the var family of virulence genes. Int J Parasitol. 2010 Jan; 40(1):35-43.
journal title abbreviation: Int J Parasitol
publication date: 2009-08-08T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

A flow cytometry-based assay for measuring invasion of red blood cells by Plasmodium falciparum.
PubMed Identifier: 20196166
author list: Bei AK, Desimone TM, Badiane AS, Ahouidi AD, Dieye T, Ndiaye D, Sarr O, Ndir O, Mboup S, Duraisingh MT
published in: American journal of hematology
information resource reference: A flow cytometry-based assay for measuring invasion of red blood cells by Plasmodium falciparum. Am J Hematol. 2010 Apr; 85(4):234-7.
journal title abbreviation: Am J Hematol
publication date: 2010-04-01T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 102006
type: Authorship
author rank in publication: 15
linked author: Duraisingh, Manoj
linked information resource: Evidence-based annotation of the malaria parasite's genome using comparative expression profiling.

Authorship 1066271
type: Authorship
author rank in publication: 14
linked author: Duraisingh, Manoj
linked information resource: Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection.

Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection.
PubMed Identifier: 29739900
author list: Obaldia N, Meibalan E, Sa JM, Ma S, Clark MA, Mejia P, Moraes Barros RR, Otero W, Ferreira MU, Mitchell JR, Milner DA, Huttenhower C, Wirth DF, Duraisingh MT, Wellems TE, Marti M
published in: mBio
information resource reference: Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection. mBio. 2018 05 08; 9(3).
journal title abbreviation: mBio
publication date: 2018-05-08T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification and disruption of the gene encoding the third member of the low-molecular-mass rhoptry complex in Plasmodium falciparum.
PubMed Identifier: 12183575
author list: Baldi DL, Good R, Duraisingh MT, Crabb BS, Cowman AF
published in: Infection and immunity
information resource reference: Identification and disruption of the gene encoding the third member of the low-molecular-mass rhoptry complex in Plasmodium falciparum. Infect Immun. 2002 Sep; 70(9):5236-45.
journal title abbreviation: Infect Immun
publication date: 2002-09-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1073869
type: Authorship
author rank in publication: 1
linked author: Duraisingh, Manoj
linked information resource: Epigenetic Variation and Regulation in Malaria Parasites.

Epigenetic Variation and Regulation in Malaria Parasites.
PubMed Identifier: 29927705
author list: Duraisingh MT, Skillman KM
published in: Annual review of microbiology
information resource reference: Epigenetic Variation and Regulation in Malaria Parasites. Annu Rev Microbiol. 2018 Sep 08; 72:355-375.
journal title abbreviation: Annu Rev Microbiol
publication date: 2018-06-21T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1076114
type: Authorship
author rank in publication: 6
linked author: Duraisingh, Manoj
linked information resource: Resistance to Plasmodium falciparum in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition.

Resistance to Plasmodium falciparum in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition.
PubMed Identifier: 29946035
author list: Archer NM, Petersen N, Clark MA, Buckee CO, Childs LM, Duraisingh MT
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Resistance to Plasmodium falciparum in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition. Proc Natl Acad Sci U S A. 2018 07 10; 115(28):7350-7355.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2018-06-26T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Evidence-based annotation of the malaria parasite's genome using comparative expression profiling.
PubMed Identifier: 18270564
author list: Zhou Y, Ramachandran V, Kumar KA, Westenberger S, Refour P, Zhou B, Li F, Young JA, Chen K, Plouffe D, Henson K, Nussenzweig V, Carlton J, Vinetz JM, Duraisingh MT, Winzeler EA
published in: PloS one
information resource reference: Evidence-based annotation of the malaria parasite's genome using comparative expression profiling. PLoS One. 2008 Feb 13; 3(2):e1570.
journal title abbreviation: PLoS One
publication date: 2008-02-13T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Forward genetic overexpression screens to identify parasite determinants of antimalarial susceptibility
end date: 2020-05-31
principal investigator name: DURAISINGH, MANOJ T
start date: 2018-06-12
type: Grant
sponsor award id: R21AI139973

Principal Investigator
type: Researcher Role
researcher role of: Duraisingh, Manoj
contributes to: Forward genetic overexpression screens to identify parasite determinants of antimalarial susceptibility

Elucidating ligand-receptor interactions required for Plasmodium vivax blood-stage infection
end date: 2023-12-31
principal investigator name: DURAISINGH, MANOJ T
start date: 2018-07-01
type: Grant
sponsor award id: R01AI140751

Principal Investigator
type: Researcher Role
researcher role of: Duraisingh, Manoj
contributes to: Elucidating ligand-receptor interactions required for Plasmodium vivax blood-stage infection

Heterochromatin-mediated control of virulence gene expression.
PubMed Identifier: 17076663
author list: Merrick CJ, Duraisingh MT
published in: Molecular microbiology
information resource reference: Heterochromatin-mediated control of virulence gene expression. Mol Microbiol. 2006 Nov; 62(3):612-20.
journal title abbreviation: Mol Microbiol
publication date: 2006-11-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Genetic analysis of the cytoplasmic domain of the PfRh2b merozoite invasion protein of Plasmodium falciparum.
PubMed Identifier: 18831976
author list: DeSimone TM, Bei AK, Jennings CV, Duraisingh MT
published in: International journal for parasitology
information resource reference: Genetic analysis of the cytoplasmic domain of the PfRh2b merozoite invasion protein of Plasmodium falciparum. Int J Parasitol. 2009 Mar; 39(4):399-405.
journal title abbreviation: Int J Parasitol
publication date: 2008-09-19T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Unravelling a histone code for malaria virulence.
PubMed Identifier: 18028316
author list: Comeaux CA, Duraisingh MT
published in: Molecular microbiology
information resource reference: Unravelling a histone code for malaria virulence. Mol Microbiol. 2007 Dec; 66(6):1291-5.
journal title abbreviation: Mol Microbiol
publication date: 2007-11-19T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal.
PubMed Identifier: 23103895
author list: Badiane AS, Sarr O, Deme AB, Ahouidi AD, Gueye PE, Ndiaye M, Seck MC, Diallo M, Bei AK, Duraisingh MT, Wirth D, Ndiaye D, Ndir O, Mboup S
published in: Journal of infection in developing countries
information resource reference: Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal. J Infect Dev Ctries. 2012 Oct 19; 6(10):727-33.
journal title abbreviation: J Infect Dev Ctries
publication date: 2012-10-19T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Functional diversification between two related Plasmodium falciparum merozoite invasion ligands is determined by changes in the cytoplasmic domain.
PubMed Identifier: 20487292
author list: Dvorin JD, Bei AK, Coleman BI, Duraisingh MT
published in: Molecular microbiology
information resource reference: Functional diversification between two related Plasmodium falciparum merozoite invasion ligands is determined by changes in the cytoplasmic domain. Mol Microbiol. 2010 Feb; 75(4):990-1006.
journal title abbreviation: Mol Microbiol
publication date: 2010-02-01T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Improving malaria control in West Africa: interruption of transmission as a paradigm shift.
PubMed Identifier: 22142790
author list: Doumbia SO, Ndiaye D, Koita OA, Diakité M, Nwakanma D, Coulibaly M, Traoré SF, Keating J, Milner DA, Ndiaye JL, Sene PD, Ahouidi A, Dieye TN, Gaye O, Okebe J, Ceesay SJ, Ngwa A, Oriero EC, Konaté L, Sy N, Jawara M, Faye O, Kéita M, Cissé M, Sogoba N, Poudiougou B, Diawara S, Sangaré L, Coulibaly T, Seck I, Abubakar I, Gomis J, Mather FJ, Sissako A, Diarra A, Kandeh B, Whalen C, Moyer B, Nnedu O, Thiero O, Bei AK, Daniels R, Miura K, Long CA, Fairhurst RM, Duraisingh M, Muskavitch MA, D'Alessandro U, Conway DJ, Volkman SK, Valim C, Wirth DF, Krogstad DJ
published in: Acta tropica
information resource reference: Improving malaria control in West Africa: interruption of transmission as a paradigm shift. Acta Trop. 2012 Mar; 121(3):175-83.
journal title abbreviation: Acta Trop
publication date: 2011-11-28T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes.
PubMed Identifier: 22119584
author list: Ceesay SJ, Bojang KA, Nwakanma D, Conway DJ, Koita OA, Doumbia SO, Ndiaye D, Coulibaly TF, Diakité M, Traoré SF, Coulibaly M, Ndiaye JL, Sarr O, Gaye O, Konaté L, Sy N, Faye B, Faye O, Sogoba N, Jawara M, Dao A, Poudiougou B, Diawara S, Okebe J, Sangaré L, Abubakar I, Sissako A, Diarra A, Kéita M, Kandeh B, Long CA, Fairhurst RM, Duraisingh M, Perry R, Muskavitch MA, Valim C, Volkman SK, Wirth DF, Krogstad DJ
published in: Acta tropica
information resource reference: Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes. Acta Trop. 2012 Mar; 121(3):166-74.
journal title abbreviation: Acta Trop
publication date: 2011-11-19T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Tennessen, Jacob
eCommons Login: JAJ39
first name: Jacob
last name: Tennessen
full name: Jacob Tennessen, Ph.D.
has faculty rank: Other Faculty
photo: https://connects.catalyst.harvard.edu/Profiles/profile/Modules/CustomViewPersonGeneralInfo/PhotoHandler.ashx
Person ID: 173289
person in primary position: Research Scientist
type: Agent
type: Person
preferred title: Research Scientist

Authorship 1095513
type: Authorship
author rank in publication: 14
linked author: Duraisingh, Manoj
linked information resource: Erythrocytes lacking the Langereis blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparum.

Erythrocytes lacking the Langereis blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparum.
PubMed Identifier: 30271928
author list: Egan ES, Weekes MP, Kanjee U, Manzo J, Srinivasan A, Lomas-Francis C, Westhoff C, Takahashi J, Tanaka M, Watanabe S, Brugnara C, Gygi SP, Tani Y, Duraisingh MT
published in: Communications biology
information resource reference: Erythrocytes lacking the Langereis blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparum. Commun Biol. 2018; 1:45.
journal title abbreviation: Commun Biol
publication date: 2018-05-03T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum.
PubMed Identifier: 16925553
author list: Artavanis-Tsakonas K, Misaghi S, Comeaux CA, Catic A, Spooner E, Duraisingh MT, Ploegh HL
published in: Molecular microbiology
information resource reference: Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum. Mol Microbiol. 2006 Sep; 61(5):1187-95.
journal title abbreviation: Mol Microbiol
publication date: 2006-09-01T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity.
PubMed Identifier: 17827348
author list: Merrick CJ, Duraisingh MT
published in: Eukaryotic cell
information resource reference: Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity. Eukaryot Cell. 2007 Nov; 6(11):2081-91.
journal title abbreviation: Eukaryot Cell
publication date: 2007-09-07T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1109655
type: Authorship
author rank in publication: 4
linked author: Duraisingh, Manoj
linked information resource: Molecular and cellular interactions defining the tropism of Plasmodium vivax for reticulocytes.

Molecular and cellular interactions defining the tropism of Plasmodium vivax for reticulocytes.
PubMed Identifier: 30366310
author list: Kanjee U, Rangel GW, Clark MA, Duraisingh MT
published in: Current opinion in microbiology
information resource reference: Molecular and cellular interactions defining the tropism of Plasmodium vivax for reticulocytes. Curr Opin Microbiol. 2018 12; 46:109-115.
journal title abbreviation: Curr Opin Microbiol
publication date: 2018-10-23T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1111017
type: Authorship
author rank in publication: 3
linked author: Duraisingh, Manoj
linked information resource: To kill a piroplasm: genetic technologies to advance drug discovery and target identification in Babesia.

To kill a piroplasm: genetic technologies to advance drug discovery and target identification in Babesia.
PubMed Identifier: 30391230
author list: Keroack CD, Elsworth B, Duraisingh MT
published in: International journal for parasitology
information resource reference: To kill a piroplasm: genetic technologies to advance drug discovery and target identification in Babesia. Int J Parasitol. 2019 02; 49(2):153-163.
journal title abbreviation: Int J Parasitol
publication date: 2018-11-01T00:00:00
year: 2018
type: Academic Article
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Authorship 131927
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linked information resource: Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity.

Rational use of drugs against Plasmodium falciparum.
PubMed Identifier: 11579870
author list: Warhurst DC, Duraisingh MT
published in: Transactions of the Royal Society of Tropical Medicine and Hygiene
information resource reference: Rational use of drugs against Plasmodium falciparum. Trans R Soc Trop Med Hyg. 2001 Jul-Aug; 95(4):345-6.
journal title abbreviation: Trans R Soc Trop Med Hyg
publication date: 2001-07-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development.
PubMed Identifier: 11839179
author list: Cowman AF, Baldi DL, Duraisingh M, Healer J, Mills KE, O'Donnell RA, Thompson J, Triglia T, Wickham ME, Crabb BS
published in: Philosophical transactions of the Royal Society of London. Series B, Biological sciences
information resource reference: Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development. Philos Trans R Soc Lond B Biol Sci. 2002 Jan 29; 357(1417):25-33.
journal title abbreviation: Philos Trans R Soc Lond B Biol Sci
publication date: 2002-01-29T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens.
PubMed Identifier: 19931645
author list: Ahouidi AD, Bei AK, Neafsey DE, Sarr O, Volkman S, Milner D, Cox-Singh J, Ferreira MU, Ndir O, Premji Z, Mboup S, Duraisingh MT
published in: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
information resource reference: Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens. Infect Genet Evol. 2010 Mar; 10(2):200-6.
journal title abbreviation: Infect Genet Evol
publication date: 2009-11-30T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Epigenetics in Plasmodium: what do we really know?
PubMed Identifier: 20562224
author list: Merrick CJ, Duraisingh MT
published in: Eukaryotic cell
information resource reference: Epigenetics in Plasmodium: what do we really know? Eukaryot Cell. 2010 Aug; 9(8):1150-8.
journal title abbreviation: Eukaryot Cell
publication date: 2010-06-18T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1119077
type: Authorship
author rank in publication: 15
linked author: Duraisingh, Manoj
linked information resource: Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex.

Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex.
PubMed Identifier: 30542156
author list: Wong W, Huang R, Menant S, Hong C, Sandow JJ, Birkinshaw RW, Healer J, Hodder AN, Kanjee U, Tonkin CJ, Heckmann D, Soroka V, Søgaard TMM, Jørgensen T, Duraisingh MT, Czabotar PE, de Jongh WA, Tham WH, Webb AI, Yu Z, Cowman AF
published in: Nature
information resource reference: Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex. Nature. 2019 01; 565(7737):118-121.
journal title abbreviation: Nature
publication date: 2018-12-12T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Inoculum effect leads to overestimation of in vitro resistance for artemisinin derivatives and standard antimalarials: a Gambian field study.
PubMed Identifier: 10599075
author list: Duraisingh MT, Jones P, Sambou I, von Seidlein L, Pinder M, Warhurst DC
published in: Parasitology
information resource reference: Inoculum effect leads to overestimation of in vitro resistance for artemisinin derivatives and standard antimalarials: a Gambian field study. Parasitology. 1999 Nov; 119 ( Pt 5):435-40.
journal title abbreviation: Parasitology
publication date: 1999-11-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3.
PubMed Identifier: 20042598
author list: Artavanis-Tsakonas K, Weihofen WA, Antos JM, Coleman BI, Comeaux CA, Duraisingh MT, Gaudet R, Ploegh HL
published in: The Journal of biological chemistry
information resource reference: Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3. J Biol Chem. 2010 Feb 26; 285(9):6857-66.
journal title abbreviation: J Biol Chem
publication date: 2009-12-30T00:00:00
year: 2009
type: Academic Article
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type: Document
type: Information Resource

Protozoan Proteins
MeSH DescriptorUI: D015800
MeSH semantic group name: Chemicals & Drugs
number of authors: 180
number of publications: 880
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type: Concept

Malaria, Falciparum
MeSH DescriptorUI: D016778
MeSH semantic group name: Disorders
number of authors: 181
number of publications: 1073
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Malaria, Vivax
MeSH DescriptorUI: D016780
MeSH semantic group name: Disorders
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number of publications: 172
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Erythrocytes
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MeSH semantic group name: Anatomy
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number of publications: 2391
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Authorship 1146925
type: Authorship
author rank in publication: 3
linked author: Duraisingh, Manoj
linked information resource: Elucidating Host Cell Uptake by Malaria Parasites.

Elucidating Host Cell Uptake by Malaria Parasites.
PubMed Identifier: 31003757
author list: Elsworth B, Keroack CD, Duraisingh MT
published in: Trends in parasitology
information resource reference: Elucidating Host Cell Uptake by Malaria Parasites. Trends Parasitol. 2019 05; 35(5):333-335.
journal title abbreviation: Trends Parasitol
publication date: 2019-04-16T00:00:00
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type: Academic Article
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type: Information Resource

Plasmodium falciparum
MeSH DescriptorUI: D010963
MeSH semantic group name: Living Beings
number of authors: 223
number of publications: 1728
uniqueness weight: 0.489983
type: Concept

Authorship 119148
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Mechanisms of gene regulation in Plasmodium.

Immunology and Infectious Diseases
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Malaria/Wirth
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Pediatrics
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type: Organization

Infectious Disease
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type: Organization

Boston Children's Hospital
type: Organization

Harvard T.H. Chan School of Public Health
type: Organization

Authorship 120680
type: Authorship
author rank in publication: 6
linked author: Duraisingh, Manoj
linked information resource: Gambian children successfully treated with chloroquine can harbor and transmit Plasmodium falciparum gametocytes carrying resistance genes.

Marti, Matthias
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Wirth, Dyann
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Neafsey, Daniel
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Authorship 1157185
type: Authorship
author rank in publication: 11
linked author: Duraisingh, Manoj
linked information resource: Generation of an immortalized erythroid progenitor cell line from peripheral blood: A model system for the functional analysis of Plasmodium spp. invasion.

Generation of an immortalized erythroid progenitor cell line from peripheral blood: A model system for the functional analysis of Plasmodium spp. invasion.
PubMed Identifier: 31148215
author list: Scully EJ, Shabani E, Rangel GW, Grüring C, Kanjee U, Clark MA, Chaand M, Kurita R, Nakamura Y, Ferreira MU, Duraisingh MT
published in: American journal of hematology
information resource reference: Generation of an immortalized erythroid progenitor cell line from peripheral blood: A model system for the functional analysis of Plasmodium spp. invasion. Am J Hematol. 2019 09; 94(9):963-974.
journal title abbreviation: Am J Hematol
publication date: 2019-06-18T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Ndiaye, Daouda
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first name: Daouda
last name: Ndiaye
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person in primary position: Visiting Scientist
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Cowman, Alan
eCommons Login: AFC3
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has faculty rank: Other Faculty
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person in primary position: Visiting Scientist
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Dvorin, Jeffrey
eCommons Login: JDD14
first name: Jeffrey
last name: Dvorin
full name: Jeffrey D. Dvorin, M.D., Ph.D.
has faculty rank: Associate Professor
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person in primary position: Associate Professor of Pediatrics
type: Agent
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preferred title: Associate Professor of Pediatrics

Authorship 1173100
type: Authorship
author rank in publication: 3
linked author: Duraisingh, Manoj
linked information resource: Fetal hemoglobin does not inhibit Plasmodium falciparum growth.

Fetal hemoglobin does not inhibit Plasmodium falciparum growth.
PubMed Identifier: 31311778
author list: Archer NM, Petersen N, Duraisingh MT
published in: Blood advances
information resource reference: Fetal hemoglobin does not inhibit Plasmodium falciparum growth. Blood Adv. 2019 07 23; 3(14):2149-2152.
journal title abbreviation: Blood Adv
publication date: 2019-07-23T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1192478
type: Authorship
author rank in publication: 9
linked author: Duraisingh, Manoj
linked information resource: Quantitative comparative analysis of human erythrocyte surface proteins between individuals from two genetically distinct populations.

Quantitative comparative analysis of human erythrocyte surface proteins between individuals from two genetically distinct populations.
PubMed Identifier: 31552303
author list: Ravenhill BJ, Kanjee U, Ahouidi A, Nobre L, Williamson J, Goldberg JM, Antrobus R, Dieye T, Duraisingh MT, Weekes MP
published in: Communications biology
information resource reference: Quantitative comparative analysis of human erythrocyte surface proteins between individuals from two genetically distinct populations. Commun Biol. 2019; 2:350.
journal title abbreviation: Commun Biol
publication date: 2019-09-20T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1194396
type: Authorship
author rank in publication: 12
linked author: Duraisingh, Manoj
linked information resource: Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand.

Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand.
PubMed Identifier: 31586047
author list: Proto WR, Siegel SV, Dankwa S, Liu W, Kemp A, Marsden S, Zenonos ZA, Unwin S, Sharp PM, Wright GJ, Hahn BH, Duraisingh MT, Rayner JC
published in: Nature communications
information resource reference: Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand. Nat Commun. 2019 10 04; 10(1):4512.
journal title abbreviation: Nat Commun
publication date: 2019-10-04T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 154100
type: Authorship
author rank in publication: 7
linked author: Duraisingh, Manoj
linked information resource: Optimization of flow cytometric detection and cell sorting of transgenic Plasmodium parasites using interchangeable optical filters.

Authorship 1216079
type: Authorship
author rank in publication: 9
linked author: Duraisingh, Manoj
linked information resource: Quantitative comparative analysis of human erythrocyte surface proteins between individuals from two genetically distinct populations.

Quantitative comparative analysis of human erythrocyte surface proteins between individuals from two genetically distinct populations.
PubMed Identifier: 31925190
author list: Ravenhill BJ, Kanjee U, Ahouidi A, Nobre L, Williamson J, Goldberg JM, Antrobus R, Dieye T, Duraisingh MT, Weekes MP
published in: Communications biology
information resource reference: Quantitative comparative analysis of human erythrocyte surface proteins between individuals from two genetically distinct populations. Commun Biol. 2019 Sep 20; 2(1):350.
journal title abbreviation: Commun Biol
publication date: 2019-09-20T00:00:00
year: 2019
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1232197
type: Authorship
author rank in publication: 8
linked author: Duraisingh, Manoj
linked information resource: Plasmodium vivax transcriptional profiling of low input cryopreserved isolates through the intraerythrocytic development cycle.

Plasmodium vivax transcriptional profiling of low input cryopreserved isolates through the intraerythrocytic development cycle.
PubMed Identifier: 32119669
author list: Rangel GW, Clark MA, Kanjee U, Goldberg JM, MacInnis B, José Menezes M, Ferreira MU, Duraisingh MT
published in: PLoS neglected tropical diseases
information resource reference: Plasmodium vivax transcriptional profiling of low input cryopreserved isolates through the intraerythrocytic development cycle. PLoS Negl Trop Dis. 2020 03; 14(3):e0008104.
journal title abbreviation: PLoS Negl Trop Dis
publication date: 2020-03-02T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Accounting for red blood cell accessibility reveals distinct invasion strategies in Plasmodium falciparum strains.
PubMed Identifier: 32315315
author list: Cai FY, DeSimone TM, Hansen E, Jennings CV, Bei AK, Ahouidi AD, Mboup S, Duraisingh MT, Buckee CO
published in: PLoS computational biology
information resource reference: Accounting for red blood cell accessibility reveals distinct invasion strategies in Plasmodium falciparum strains. PLoS Comput Biol. 2020 04; 16(4):e1007702.
journal title abbreviation: PLoS Comput Biol
publication date: 2020-04-21T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1240208
type: Authorship
author rank in publication: 8
linked author: Duraisingh, Manoj
linked information resource: Accounting for red blood cell accessibility reveals distinct invasion strategies in Plasmodium falciparum strains.

Developing comparative chemical genomics and genetic validation tools for Babesia spp.
end date: 2022-05-31
principal investigator name: DURAISINGH, MANOJ T
start date: 2020-06-12
type: Grant
sponsor award id: R21AI153945

Principal Investigator
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researcher role of: Duraisingh, Manoj
contributes to: Developing comparative chemical genomics and genetic validation tools for Babesia spp.

Authorship 1257941
type: Authorship
author rank in publication: 11
linked author: Duraisingh, Manoj
linked information resource: Fussing About Fission: Defining Variety Among Mainstream and Exotic Apicomplexan Cell Division Modes.

Fussing About Fission: Defining Variety Among Mainstream and Exotic Apicomplexan Cell Division Modes.
PubMed Identifier: 32582569
author list: Gubbels MJ, Keroack CD, Dangoudoubiyam S, Worliczek HL, Paul AS, Bauwens C, Elsworth B, Engelberg K, Howe DK, Coppens I, Duraisingh MT
published in: Frontiers in cellular and infection microbiology
information resource reference: Fussing About Fission: Defining Variety Among Mainstream and Exotic Apicomplexan Cell Division Modes. Front Cell Infect Microbiol. 2020; 10:269.
journal title abbreviation: Front Cell Infect Microbiol
publication date: 2020-06-05T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 136394
type: Authorship
author rank in publication: 9
linked author: Duraisingh, Manoj
linked information resource: Erythrocyte invasion profiles are associated with a common invasion ligand polymorphism in Senegalese isolates of Plasmodium falciparum.

Authorship 14226
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Epigenetics in Plasmodium: what do we really know?

Authorship 15277
type: Authorship
author rank in publication: 6
linked author: Duraisingh, Manoj
linked information resource: Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum.

Authorship 1269865
type: Authorship
author rank in publication: 15
linked author: Duraisingh, Manoj
linked information resource: Co-option of Plasmodium falciparum PP1 for egress from host erythrocytes.

Authorship 1270008
type: Authorship
author rank in publication: 12
linked author: Duraisingh, Manoj
linked information resource: Keras R-CNN: library for cell detection in biological images using deep neural networks.

Keras R-CNN: library for cell detection in biological images using deep neural networks.
PubMed Identifier: 32652926
author list: Hung J, Goodman A, Ravel D, Lopes SCP, Rangel GW, Nery OA, Malleret B, Nosten F, Lacerda MVG, Ferreira MU, Rénia L, Duraisingh MT, Costa FTM, Marti M, Carpenter AE
published in: BMC bioinformatics
information resource reference: Keras R-CNN: library for cell detection in biological images using deep neural networks. BMC Bioinformatics. 2020 Jul 11; 21(1):300.
journal title abbreviation: BMC Bioinformatics
publication date: 2020-07-11T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

Co-option of Plasmodium falciparum PP1 for egress from host erythrocytes.
PubMed Identifier: 32669539
author list: Paul AS, Miliu A, Paulo JA, Goldberg JM, Bonilla AM, Berry L, Seveno M, Braun-Breton C, Kosber AL, Elsworth B, Arriola JSN, Lebrun M, Gygi SP, Lamarque MH, Duraisingh MT
published in: Nature communications
information resource reference: Co-option of Plasmodium falciparum PP1 for egress from host erythrocytes. Nat Commun. 2020 07 15; 11(1):3532.
journal title abbreviation: Nat Commun
publication date: 2020-07-15T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
type: Information Resource

https://connects.catalyst.harvard.edu/Profiles/profile/167201336
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Wadham College, University of Oxford,
end date: 1993
educational organization: Wadham College, University of Oxford
training location: Oxford, United Kingdom
type: EducationalTraining
degree earned: B.A.Hons

London School of Hygiene and Tropical Medicine,
end date: 1994
educational organization: London School of Hygiene and Tropical Medicine
training location: London, United Kingdom
type: EducationalTraining
degree earned: M.Sc.

London School of Hygiene and Tropical Medicine,
end date: 1999
educational organization: London School of Hygiene and Tropical Medicine
training location: London, United Kingdom
type: EducationalTraining
degree earned: PhD

Authorship 1284765
type: Authorship
author rank in publication: 14
linked author: Duraisingh, Manoj
linked information resource: Plasmodium vivax Strains Use Alternative Pathways for Invasion.

Plasmodium vivax Strains Use Alternative Pathways for Invasion.
PubMed Identifier: 32941614
author list: Kanjee U, Grüring C, Babar P, Meyers A, Dash R, Pereira L, Mascarenhas A, Chaand M, Rangel GW, Clark MA, Chery L, Gomes E, Rathod PK, Duraisingh MT
published in: The Journal of infectious diseases
information resource reference: Plasmodium vivax Strains Use Alternative Pathways for Invasion. J Infect Dis. 2021 05 28; 223(10):1817-1821.
journal title abbreviation: J Infect Dis
publication date: 2021-05-28T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1289480
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Transformative tools for parasitic flatworms.

Transformative tools for parasitic flatworms.
PubMed Identifier: 32973017
author list: Anderson TJC, Duraisingh MT
published in: Science (New York, N.Y.)
information resource reference: Transformative tools for parasitic flatworms. Science. 2020 09 25; 369(6511):1562-1564.
journal title abbreviation: Science
publication date: 2020-09-25T00:00:00
year: 2020
type: Academic Article
type: Article
type: Document
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Dass, Sheena
eCommons Login: shd747
first name: Sheena
last name: Dass
full name: Sheena Dass, Ph.D.
has faculty rank: Other Faculty
Person ID: 194811
person in primary position: Research Associate
type: Agent
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Authorship 1303737
type: Authorship
author rank in publication: 3
linked author: Duraisingh, Manoj
linked information resource: Linking nutrient sensing and gene expression in Plasmodium falciparum blood-stage parasites.

Authorship 1306758
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Three Signatures of Adaptive Polymorphism Exemplified by Malaria-Associated Genes.

Linking nutrient sensing and gene expression in Plasmodium falciparum blood-stage parasites.
PubMed Identifier: 33236377
author list: Kumar M, Skillman K, Duraisingh MT
published in: Molecular microbiology
information resource reference: Linking nutrient sensing and gene expression in Plasmodium falciparum blood-stage parasites. Mol Microbiol. 2021 05; 115(5):891-900.
journal title abbreviation: Mol Microbiol
publication date: 2020-12-13T00:00:00
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Three Signatures of Adaptive Polymorphism Exemplified by Malaria-Associated Genes.
PubMed Identifier: 33185667
author list: Tennessen JA, Duraisingh MT
published in: Molecular biology and evolution
information resource reference: Three Signatures of Adaptive Polymorphism Exemplified by Malaria-Associated Genes. Mol Biol Evol. 2021 04 13; 38(4):1356-1371.
journal title abbreviation: Mol Biol Evol
publication date: 2021-04-13T00:00:00
year: 2021
type: Academic Article
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Authorship 1308481
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linked author: Duraisingh, Manoj
linked information resource: A framework for signaling throughout the life cycle of Babesia species.

A framework for signaling throughout the life cycle of Babesia species.
PubMed Identifier: 33274587
author list: Elsworth B, Duraisingh MT
published in: Molecular microbiology
information resource reference: A framework for signaling throughout the life cycle of Babesia species. Mol Microbiol. 2021 05; 115(5):882-890.
journal title abbreviation: Mol Microbiol
publication date: 2020-12-15T00:00:00
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type: Academic Article
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Authorship 1330948
type: Authorship
author rank in publication: 12
linked author: Duraisingh, Manoj
linked information resource: Author Correction: Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand.

Author Correction: Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand.
PubMed Identifier: 33594063
author list: Proto WR, Siegel SV, Dankwa S, Liu W, Kemp A, Marsden S, Zenonos ZA, Unwin S, Sharp PM, Wright GJ, Hahn BH, Duraisingh MT, Rayner JC
published in: Nature communications
information resource reference: Author Correction: Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand. Nat Commun. 2021 Feb 16; 12(1):1188.
journal title abbreviation: Nat Commun
publication date: 2021-02-16T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1337557
type: Authorship
author rank in publication: 10
linked author: Duraisingh, Manoj
linked information resource: Plasmodium vivax infection compromises reticulocyte stability.

Plasmodium vivax infection compromises reticulocyte stability.
PubMed Identifier: 33712609
author list: Clark MA, Kanjee U, Rangel GW, Chery L, Mascarenhas A, Gomes E, Rathod PK, Brugnara C, Ferreira MU, Duraisingh MT
published in: Nature communications
information resource reference: Plasmodium vivax infection compromises reticulocyte stability. Nat Commun. 2021 03 12; 12(1):1629.
journal title abbreviation: Nat Commun
publication date: 2021-03-12T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1347123
type: Authorship
author rank in publication: 4
linked author: Duraisingh, Manoj
linked information resource: The Modular Circuitry of Apicomplexan Cell Division Plasticity.

The Modular Circuitry of Apicomplexan Cell Division Plasticity.
PubMed Identifier: 33912479
author list: Gubbels MJ, Coppens I, Zarringhalam K, Duraisingh MT, Engelberg K
published in: Frontiers in cellular and infection microbiology
information resource reference: The Modular Circuitry of Apicomplexan Cell Division Plasticity. Front Cell Infect Microbiol. 2021; 11:670049.
journal title abbreviation: Front Cell Infect Microbiol
publication date: 2021-04-12T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1353213
type: Authorship
author rank in publication: 3
linked author: Duraisingh, Manoj
linked information resource: The molecular basis of antimalarial drug resistance in Plasmodium vivax.

The molecular basis of antimalarial drug resistance in Plasmodium vivax.
PubMed Identifier: 33957488
author list: Buyon LE, Elsworth B, Duraisingh MT
published in: International journal for parasitology. Drugs and drug resistance
information resource reference: The molecular basis of antimalarial drug resistance in Plasmodium vivax. Int J Parasitol Drugs Drug Resist. 2021 08; 16:23-37.
journal title abbreviation: Int J Parasitol Drugs Drug Resist
publication date: 2021-04-26T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1364890
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Deconstructing the parasite multiplication rate of Plasmodium falciparum.

Deconstructing the parasite multiplication rate of Plasmodium falciparum.
PubMed Identifier: 34119440
author list: Gnangnon B, Duraisingh MT, Buckee CO
published in: Trends in parasitology
information resource reference: Deconstructing the parasite multiplication rate of Plasmodium falciparum. Trends Parasitol. 2021 10; 37(10):922-932.
journal title abbreviation: Trends Parasitol
publication date: 2021-06-10T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 172413
type: Authorship
author rank in publication: 1
linked author: Duraisingh, Manoj
linked information resource: Multiple drug resistance genes in malaria -- from epistasis to epidemiology.

Authorship 1417323
type: Authorship
author rank in publication: 19
linked author: Duraisingh, Manoj
linked information resource: Structural organization of erythrocyte membrane microdomains and their relation with malaria susceptibility.

Structural organization of erythrocyte membrane microdomains and their relation with malaria susceptibility.
PubMed Identifier: 34880413
author list: Olivieri A, Lee RS, Fratini F, Keutcha C, Chaand M, Mangano V, Celani F, Mochi S, Birago C, Paone S, Grasso F, Tirelli V, Falchi M, Shabani E, Bertoncini S, Sirima BS, Pizzi E, Modiano D, Duraisingh MT, Ponzi M
published in: Communications biology
information resource reference: Structural organization of erythrocyte membrane microdomains and their relation with malaria susceptibility. Commun Biol. 2021 12 08; 4(1):1375.
journal title abbreviation: Commun Biol
publication date: 2021-12-08T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1420726
type: Authorship
author rank in publication: 6
linked author: Duraisingh, Manoj
linked information resource: Applying Faster R-CNN for Object Detection on Malaria Images.

Applying Faster R-CNN for Object Detection on Malaria Images.
PubMed Identifier: 34938593
author list: Hung J, Lopes SCP, Nery OA, Nosten F, Ferreira MU, Duraisingh MT, Marti M, Ravel D, Rangel G, Malleret B, Lacerda MVG, Rénia L, Costa FTM, Carpenter AE
published in: Conference on Computer Vision and Pattern Recognition Workshops. IEEE Computer Society Conference on Computer Vision and Pattern Recognition. Workshops
information resource reference: Applying Faster R-CNN for Object Detection on Malaria Images. Conf Comput Vis Pattern Recognit Workshops. 2017 Jul; 2017:808-813.
journal title abbreviation: Conf Comput Vis Pattern Recognit Workshops
publication date: 2021-11-18T00:00:00
year: 2021
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1421987
type: Authorship
author rank in publication: 3
linked author: Duraisingh, Manoj
linked information resource: RBC membrane biomechanics and Plasmodium falciparum invasion: probing beyond ligand-receptor interactions.

RBC membrane biomechanics and Plasmodium falciparum invasion: probing beyond ligand-receptor interactions.
PubMed Identifier: 34991983
author list: Groomes PV, Kanjee U, Duraisingh MT
published in: Trends in parasitology
information resource reference: RBC membrane biomechanics and Plasmodium falciparum invasion: probing beyond ligand-receptor interactions. Trends Parasitol. 2022 04; 38(4):302-315.
journal title abbreviation: Trends Parasitol
publication date: 2022-01-04T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1441164
type: Authorship
author rank in publication: 9
linked author: Duraisingh, Manoj
linked information resource: Purinergic signaling is essential for full Psickle activation by hypoxia and by normoxic acid pH in mature human sickle red cells and in vitro-differentiated cultured human sickle reticulocytes.

Purinergic signaling is essential for full Psickle activation by hypoxia and by normoxic acid pH in mature human sickle red cells and in vitro-differentiated cultured human sickle reticulocytes.
PubMed Identifier: 35169901
author list: Vandorpe DH, Rivera A, Ganter M, Dankwa S, Wohlgemuth JG, Dlott JS, Snyder LM, Brugnara C, Duraisingh M, Alper SL
published in: Pflugers Archiv : European journal of physiology
information resource reference: Purinergic signaling is essential for full Psickle activation by hypoxia and by normoxic acid pH in mature human sickle red cells and in vitro-differentiated cultured human sickle reticulocytes. Pflugers Arch. 2022 05; 474(5):553-565.
journal title abbreviation: Pflugers Arch
publication date: 2022-02-16T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

A Malaria Parasite Cross Reveals Genetic Determinants of Plasmodium falciparum Growth in Different Culture Media.
PubMed Identifier: 35711667
author list: Kumar S, Li X, McDew-White M, Reyes A, Delgado E, Sayeed A, Haile MT, Abatiyow BA, Kennedy SY, Camargo N, Checkley LA, Brenneman KV, Button-Simons KA, Duraisingh MT, Cheeseman IH, Kappe SHI, Nosten F, Ferdig MT, Vaughan AM, Anderson TJC
published in: Frontiers in cellular and infection microbiology
information resource reference: A Malaria Parasite Cross Reveals Genetic Determinants of Plasmodium falciparum Growth in Different Culture Media. Front Cell Infect Microbiol. 2022; 12:878496.
journal title abbreviation: Front Cell Infect Microbiol
publication date: 2022-05-30T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1459056
type: Authorship
author rank in publication: 4
linked author: Duraisingh, Manoj
linked information resource: Does fetal hemoglobin inhibit the malarial parasite Plasmodium falciparum?

Authorship 1465851
type: Authorship
author rank in publication: 14
linked author: Duraisingh, Manoj
linked information resource: A Malaria Parasite Cross Reveals Genetic Determinants of Plasmodium falciparum Growth in Different Culture Media.

Does fetal hemoglobin inhibit the malarial parasite Plasmodium falciparum?
PubMed Identifier: 35834276
author list: Archer NM, Pasvol G, Wilson I, Duraisingh MT
published in: American journal of hematology
information resource reference: Does fetal hemoglobin inhibit the malarial parasite Plasmodium falciparum? Am J Hematol. 2022 09; 97(9):E325-E327.
journal title abbreviation: Am J Hematol
publication date: 2022-07-30T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1499783
type: Authorship
author rank in publication: 23
linked author: Duraisingh, Manoj
linked information resource: The ecology and epidemiology of malaria parasitism in wild chimpanzee reservoirs.

Authorship 1492959
type: Authorship
author rank in publication: 6
linked author: Duraisingh, Manoj
linked information resource: Comparative single-cell transcriptional atlases of Babesia species reveal conserved and species-specific expression profiles.

Authorship 1494560
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Molecular mechanisms of cellular quiescence in apicomplexan parasites.

Authorship 1498071
type: Authorship
author rank in publication: 10
linked author: Duraisingh, Manoj
linked information resource: International Center of Excellence for Malaria Research for South Asia and Broader Malaria Research in India.

Authorship 1498074
type: Authorship
author rank in publication: 15
linked author: Duraisingh, Manoj
linked information resource: Diverse Malaria Presentations across National Institutes of Health South Asia International Center for Excellence in Malaria Research Sites in India.

Molecular mechanisms of cellular quiescence in apicomplexan parasites.
PubMed Identifier: 36274498
author list: Keroack CD, Duraisingh MT
published in: Current opinion in microbiology
information resource reference: Molecular mechanisms of cellular quiescence in apicomplexan parasites. Curr Opin Microbiol. 2022 12; 70:102223.
journal title abbreviation: Curr Opin Microbiol
publication date: 2022-10-21T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

International Center of Excellence for Malaria Research for South Asia and Broader Malaria Research in India.
PubMed Identifier: 36228906
author list: Mascarenhas A, Chakrabarti R, Chery-Karschney L, White J, Skillman KM, Kanjee U, Babar PH, Patrapuvich R, Mohanty AK, Duraisingh MT, Rathod PK
published in: The American journal of tropical medicine and hygiene
information resource reference: International Center of Excellence for Malaria Research for South Asia and Broader Malaria Research in India. Am J Trop Med Hyg. 2022 10 11; 107(4_Suppl):118-123.
journal title abbreviation: Am J Trop Med Hyg
publication date: 2022-10-11T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

The ecology and epidemiology of malaria parasitism in wild chimpanzee reservoirs.
PubMed Identifier: 36167977
author list: Scully EJ, Liu W, Li Y, Ndjango JN, Peeters M, Kamenya S, Pusey AE, Lonsdorf EV, Sanz CM, Morgan DB, Piel AK, Stewart FA, Gonder MK, Simmons N, Asiimwe C, Zuberbühler K, Koops K, Chapman CA, Chancellor R, Rundus A, Huffman MA, Wolfe ND, Duraisingh MT, Hahn BH, Wrangham RW
published in: Communications biology
information resource reference: The ecology and epidemiology of malaria parasitism in wild chimpanzee reservoirs. Commun Biol. 2022 09 27; 5(1):1020.
journal title abbreviation: Commun Biol
publication date: 2022-09-27T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Comparative single-cell transcriptional atlases of Babesia species reveal conserved and species-specific expression profiles.
PubMed Identifier: 36137068
author list: Rezvani Y, Keroack CD, Elsworth B, Arriojas A, Gubbels MJ, Duraisingh MT, Zarringhalam K
published in: PLoS biology
information resource reference: Comparative single-cell transcriptional atlases of Babesia species reveal conserved and species-specific expression profiles. PLoS Biol. 2022 09; 20(9):e3001816.
journal title abbreviation: PLoS Biol
publication date: 2022-09-22T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Diverse Malaria Presentations across National Institutes of Health South Asia International Center for Excellence in Malaria Research Sites in India.
PubMed Identifier: 36228910
author list: Chakrabarti R, Chery-Karschney L, White J, Mascarenhas A, Skillman KM, Kanjee U, Babar PH, Patrapuvich R, Mohapatra PK, Patankar S, Smith JD, Anvikar A, Valecha N, Rahi M, Duraisingh MT, Rathod PK
published in: The American journal of tropical medicine and hygiene
information resource reference: Diverse Malaria Presentations across National Institutes of Health South Asia International Center for Excellence in Malaria Research Sites in India. Am J Trop Med Hyg. 2022 10 11; 107(4_Suppl):107-117.
journal title abbreviation: Am J Trop Med Hyg
publication date: 2022-10-11T00:00:00
year: 2022
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 212163
type: Authorship
author rank in publication: 8
linked author: Duraisingh, Manoj
linked information resource: A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs.

Authorship 1519127
type: Authorship
author rank in publication: 1
linked author: Duraisingh, Manoj
linked information resource: A rising tide of parasite transcriptomics propels pathogen biology.

A rising tide of parasite transcriptomics propels pathogen biology.
PubMed Identifier: 36696650
author list: Duraisingh MT, Gubbels MJ, Zarringhalam K
published in: PLoS biology
information resource reference: A rising tide of parasite transcriptomics propels pathogen biology. PLoS Biol. 2023 01; 21(1):e3001997.
journal title abbreviation: PLoS Biol
publication date: 2023-01-25T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1532583
type: Authorship
author rank in publication: 12
linked author: Duraisingh, Manoj
linked information resource: Babesia divergens egress from host cells is orchestrated by essential and druggable kinases and proteases.

Babesia divergens egress from host cells is orchestrated by essential and druggable kinases and proteases.
PubMed Identifier: 36909484
author list: Elsworth B, Keroack C, Rezvani Y, Paul A, Barazorda K, Tennessen J, Sack S, Moreira C, Gubbels MJ, Meyers M, Zarringhalam K, Duraisingh M
published in: Research square
information resource reference: Babesia divergens egress from host cells is orchestrated by essential and druggable kinases and proteases. Res Sq. 2023 Feb 28.
journal title abbreviation: Res Sq
publication date: 2023-02-28T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 507506
type: Authorship
author rank in publication: 4
linked author: Duraisingh, Manoj
linked information resource: Functional diversification between two related Plasmodium falciparum merozoite invasion ligands is determined by changes in the cytoplasmic domain.

Authorship 1573409
type: Authorship
author rank in publication: 11
linked author: Duraisingh, Manoj
linked information resource: Comparative chemical genomics in Babesia species identifies the alkaline phosphatase phoD as a novel determinant of resistance.

Authorship 1552966
type: Authorship
author rank in publication: 14
linked author: Duraisingh, Manoj
linked information resource: Development of a Plasmodium vivax biobank for functional ex vivo assays.

Comparative chemical genomics in Babesia species identifies the alkaline phosphatase phoD as a novel determinant of resistance.
PubMed Identifier: 37398106
author list: Keroack CD, Elsworth B, Tennessen JA, Paul AS, Hua R, Ramirez-Ramirez L, Ye S, Moreira CM, Meyers MJ, Zarringhalam K, Duraisingh MT
published in: bioRxiv : the preprint server for biology
information resource reference: Comparative chemical genomics in Babesia species identifies the alkaline phosphatase phoD as a novel determinant of resistance. bioRxiv. 2023 Jun 13.
journal title abbreviation: bioRxiv
publication date: 2023-06-13T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Development of a Plasmodium vivax biobank for functional ex vivo assays.
PubMed Identifier: 36993272
author list: Dash R, Skillman KM, Pereira L, Mascarenhas A, Dass S, Walke J, Almeida A, Fernandes M, Gomes E, White J, Chery-Karschney L, Khandeparkar A, Rathod PK, Duraisingh MT, Kanjee U
published in: bioRxiv : the preprint server for biology
information resource reference: Development of a Plasmodium vivax biobank for functional ex vivo assays. bioRxiv. 2023 Mar 18.
journal title abbreviation: bioRxiv
publication date: 2023-03-18T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1590827
type: Authorship
author rank in publication: 14
linked author: Duraisingh, Manoj
linked information resource: Development of a Plasmodium vivax biobank for functional ex vivo assays.

Authorship 1588097
type: Authorship
author rank in publication: 9
linked author: Duraisingh, Manoj
linked information resource: The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family.

Authorship 1581422
type: Authorship
author rank in publication: 7
linked author: Duraisingh, Manoj
linked information resource: F-erythrocytes promote Plasmodium falciparum proliferation in sickle cell disease.

F-erythrocytes promote Plasmodium falciparum proliferation in sickle cell disease.
PubMed Identifier: 37584425
author list: Archer NM, Gnangnon B, Mikdar M, Ciuculescu MF, Petersen N, Staffa SJ, Duraisingh MT
published in: American journal of hematology
information resource reference: F-erythrocytes promote Plasmodium falciparum proliferation in sickle cell disease. Am J Hematol. 2023 10; 98(10):1598-1605.
journal title abbreviation: Am J Hematol
publication date: 2023-08-16T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family.
PubMed Identifier: 37709739
author list: Kundu P, Naskar D, McKie SJ, Dass S, Kanjee U, Introini V, Ferreira MU, Cicuta P, Duraisingh M, Deane JE, Rayner JC
published in: Nature communications
information resource reference: The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family. Nat Commun. 2023 09 14; 14(1):5703.
journal title abbreviation: Nat Commun
publication date: 2023-09-14T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Development of a Plasmodium vivax biobank for functional ex vivo assays.
PubMed Identifier: 37653486
author list: Dash R, Skillman KM, Pereira L, Mascarenhas A, Dass S, Walke J, Almeida A, Fernandes M, Gomes E, White J, Chery-Karschney L, Khandeparkar A, Rathod PK, Duraisingh MT, Kanjee U
published in: Malaria journal
information resource reference: Development of a Plasmodium vivax biobank for functional ex vivo assays. Malar J. 2023 Aug 31; 22(1):250.
journal title abbreviation: Malar J
publication date: 2023-08-31T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 410032
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Geographical distribution of a variant epitope of Pfs48/45, a Plasmodium falciparum transmission-blocking vaccine candidate.

Authorship 432020
type: Authorship
author rank in publication: 4
linked author: Duraisingh, Manoj
linked information resource: Plasmodium falciparum: selection of serine 108 of dihydrofolate reductase during treatment of uncomplicated malaria with co-trimoxazole in Ugandan children.

Authorship 1605406
type: Authorship
author rank in publication: 10
linked author: Duraisingh, Manoj
linked information resource: https://connects.catalyst.harvard.edu/Profiles/profile/225308795

https://connects.catalyst.harvard.edu/Profiles/profile/225308795
PubMed Identifier: 37939134
author list: Sekar P, Rajagopalan S, Shabani E, Kanjee U, Schureck MA, Arora G, Peterson ME, Traore B, Crompton PD, Duraisingh MT, Desai SA, Long EO
published in: PLoS pathogens
information resource reference: NK cell-induced damage to P.falciparum-infected erythrocytes requires ligand-specific recognition and releases parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG. PLoS Pathog. 2023 11; 19(11):e1011585.
journal title abbreviation: PLoS Pathog
publication date: 2023-11-08T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource
label: NK cell-induced damage to P.falciparum-infected erythrocytes requires ligand-specific recognition and releases parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG.

Authorship 1617672
type: Authorship
author rank in publication: 8
linked author: Duraisingh, Manoj
linked information resource: Sterile protection against P. vivax malaria by repeated blood stage infection in the Aotus monkey model.

Sterile protection against P. vivax malaria by repeated blood stage infection in the Aotus monkey model.
PubMed Identifier: 38158220
author list: Obaldía N, Da Silva Filho JL, Núñez M, Glass KA, Oulton T, Achcar F, Wirjanata G, Duraisingh M, Felgner P, Tetteh KK, Bozdech Z, Otto TD, Marti M
published in: Life science alliance
information resource reference: Sterile protection against P. vivax malaria by repeated blood stage infection in the Aotus monkey model. Life Sci Alliance. 2024 03; 7(3).
journal title abbreviation: Life Sci Alliance
publication date: 2023-12-29T00:00:00
year: 2023
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1625357
type: Authorship
author rank in publication: 3
linked author: Duraisingh, Manoj
linked information resource: Hungry for control: metabolite signaling to chromatin in Plasmodium falciparum.

Hungry for control: metabolite signaling to chromatin in Plasmodium falciparum.
PubMed Identifier: 38306915
author list: Lappalainen R, Kumar M, Duraisingh MT
published in: Current opinion in microbiology
information resource reference: Hungry for control: metabolite signaling to chromatin in Plasmodium falciparum. Curr Opin Microbiol. 2024 04; 78:102430.
journal title abbreviation: Curr Opin Microbiol
publication date: 2024-02-02T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1632694
type: Authorship
author rank in publication: 11
linked author: Duraisingh, Manoj
linked information resource: Comparative chemical genomics in Babesia species identifies the alkaline phosphatase PhoD as a determinant of antiparasitic resistance.

Comparative chemical genomics in Babesia species identifies the alkaline phosphatase PhoD as a determinant of antiparasitic resistance.
PubMed Identifier: 38377214
author list: Keroack CD, Elsworth B, Tennessen JA, Paul AS, Hua R, Ramirez-Ramirez L, Ye S, Moreira CK, Meyers MJ, Zarringhalam K, Duraisingh MT
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Comparative chemical genomics in Babesia species identifies the alkaline phosphatase PhoD as a determinant of antiparasitic resistance. Proc Natl Acad Sci U S A. 2024 Feb 27; 121(9):e2312987121.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2024-02-20T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1642842
type: Authorship
author rank in publication: 15
linked author: Duraisingh, Manoj
linked information resource: The essential malaria protein PfCyRPA targets glycans to invade erythrocytes.

Authorship 1642744
type: Authorship
author rank in publication: 3
linked author: Duraisingh, Manoj
linked information resource: Inhibition of malaria and babesiosis parasites by putative red blood cell targeting small molecules.

Inhibition of malaria and babesiosis parasites by putative red blood cell targeting small molecules.
PubMed Identifier: 38572319
author list: Groomes PV, Paul AS, Duraisingh MT
published in: Frontiers in cellular and infection microbiology
information resource reference: Inhibition of malaria and babesiosis parasites by putative red blood cell targeting small molecules. Front Cell Infect Microbiol. 2024; 14:1304839.
journal title abbreviation: Front Cell Infect Microbiol
publication date: 2024-03-20T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

The essential malaria protein PfCyRPA targets glycans to invade erythrocytes.
PubMed Identifier: 38573856
author list: Day CJ, Favuzza P, Bielfeld S, Haselhorst T, Seefeldt L, Hauser J, Shewell LK, Flueck C, Poole J, Jen FE, Schäfer A, Dangy JP, Gilberger TW, França CT, Duraisingh MT, Tamborrini M, Brancucci NMB, Grüring C, Filarsky M, Jennings MP, Pluschke G
published in: Cell reports
information resource reference: The essential malaria protein PfCyRPA targets glycans to invade erythrocytes. Cell Rep. 2024 04 23; 43(4):114012.
journal title abbreviation: Cell Rep
publication date: 2024-04-03T00:00:00
year: 2024
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 264762
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Polymorphism of the Pfmdr1 gene and chloroquine resistance in Plasmodium falciparum in The Gambia.

Molecular basis of antimalarial drug resistance in Plasmodium vivax
end date: 2027-02-28
principal investigator name: DURAISINGH, MANOJ T
start date: 2022-03-18
type: Grant
sponsor award id: R01AI168163

Comparative systems biology of apicomplexan cell division
end date: 2027-06-30
principal investigator name: GUBBELS, MARC-JAN
start date: 2022-07-21
type: Grant
sponsor award id: R01AI167570

Evaluating host-directed therapeutics against blood-stage malaria parasites
end date: 2024-06-30
principal investigator name: DURAISINGH, MANOJ T
start date: 2022-07-14
type: Grant
sponsor award id: R21AI166478

Malaria parasite determinants of host cell tropism
end date: 2027-06-30
principal investigator name: DURAISINGH, MANOJ T
start date: 2022-07-01
type: Grant
sponsor award id: R01AI165755

Developing a barcoded malaria parasite panel to assess broadly neutralizing antibodies
end date: 2024-11-30
principal investigator name: DURAISINGH, MANOJ T
start date: 2022-06-29
type: Grant
sponsor award id: R21AI171658

Linking metabolite sensing and gene expression in malaria parasites
end date: 2024-10-31
principal investigator name: DURAISINGH, MANOJ T
start date: 2022-11-09
type: Grant
sponsor award id: R21AI168806

Principal Investigator
type: Researcher Role
researcher role of: Duraisingh, Manoj
contributes to: Evaluating host-directed therapeutics against blood-stage malaria parasites

Principal Investigator
type: Researcher Role
researcher role of: Duraisingh, Manoj
contributes to: Developing a barcoded malaria parasite panel to assess broadly neutralizing antibodies

Principal Investigator
type: Researcher Role
researcher role of: Duraisingh, Manoj
contributes to: Malaria parasite determinants of host cell tropism

Principal Investigator
type: Researcher Role
researcher role of: Duraisingh, Manoj
contributes to: Linking metabolite sensing and gene expression in malaria parasites

Principal Investigator
type: Researcher Role
researcher role of: Duraisingh, Manoj
contributes to: Molecular basis of antimalarial drug resistance in Plasmodium vivax

Co-Principal Investigator
type: Researcher Role
researcher role of: Duraisingh, Manoj
contributes to: Comparative systems biology of apicomplexan cell division

Authorship 1649635
type: Authorship
author rank in publication: 18
linked author: Duraisingh, Manoj
linked information resource: Descriptive, Hospital-Based, 10-Year Study of Malaria Transmission in Goa, a Southwest Indian State in the Malaria Elimination Phase.

Descriptive, Hospital-Based, 10-Year Study of Malaria Transmission in Goa, a Southwest Indian State in the Malaria Elimination Phase.
PubMed Identifier: 38714193
author list: Chakrabarti R, Gillespie K, Walke JT, Fernandes M, Almeida A, Chery-Karschney L, Kanjee U, Skillman KM, White J, Babar PH, Pereira L, Mascarenhas A, Vaz M, Khandeparkar A, Gomes E, Janes H, Rathod PK, Duraisingh MT
published in: The American journal of tropical medicine and hygiene
information resource reference: Descriptive, Hospital-Based, 10-Year Study of Malaria Transmission in Goa, a Southwest Indian State in the Malaria Elimination Phase. Am J Trop Med Hyg. 2024 Jul 03; 111(1):11-25.
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Authorship 1665685
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linked information resource: Disruption of Plasmodium falciparum kinetochore proteins destabilises the nexus between the centrosome equivalent and the mitotic apparatus.

Disruption of Plasmodium falciparum kinetochore proteins destabilises the nexus between the centrosome equivalent and the mitotic apparatus.
PubMed Identifier: 38987258
author list: Li J, Shami GJ, Liffner B, Cho E, Braet F, Duraisingh MT, Absalon S, Dixon MWA, Tilley L
published in: Nature communications
information resource reference: Disruption of Plasmodium falciparum kinetochore proteins destabilises the nexus between the centrosome equivalent and the mitotic apparatus. Nat Commun. 2024 Jul 10; 15(1):5794.
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Authorship 379381
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linked author: Duraisingh, Manoj
linked information resource: Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes.

Authorship 1684913
type: Authorship
author rank in publication: 8
linked author: Duraisingh, Manoj
linked information resource: Single cell expression and chromatin accessibility of the Toxoplasma gondii lytic cycle identifies AP2XII-8 as an essential ribosome regulon driver.

Single cell expression and chromatin accessibility of the Toxoplasma gondii lytic cycle identifies AP2XII-8 as an essential ribosome regulon driver.
PubMed Identifier: 39198388
author list: Lou J, Rezvani Y, Arriojas A, Wu Y, Shankar N, Degras D, Keroack CD, Duraisingh MT, Zarringhalam K, Gubbels MJ
published in: Nature communications
information resource reference: Single cell expression and chromatin accessibility of the Toxoplasma gondii lytic cycle identifies AP2XII-8 as an essential ribosome regulon driver. Nat Commun. 2024 Aug 28; 15(1):7419.
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Authorship 660817
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linked information resource: Specific phosphorylation of the PfRh2b invasion ligand of Plasmodium falciparum.

Authorship 656982
type: Authorship
author rank in publication: 11
linked author: Duraisingh, Manoj
linked information resource: Inhibitory humoral responses to the Plasmodium falciparum vaccine candidate EBA-175 are independent of the erythrocyte invasion pathway.

Specific phosphorylation of the PfRh2b invasion ligand of Plasmodium falciparum.
PubMed Identifier: 23544851
author list: Engelberg K, Paul AS, Prinz B, Kono M, Ching W, Heincke D, Dobner T, Spielmann T, Duraisingh MT, Gilberger TW
published in: The Biochemical journal
information resource reference: Specific phosphorylation of the PfRh2b invasion ligand of Plasmodium falciparum. Biochem J. 2013 Jun 15; 452(3):457-66.
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Inhibitory humoral responses to the Plasmodium falciparum vaccine candidate EBA-175 are independent of the erythrocyte invasion pathway.
PubMed Identifier: 23761656
author list: Badiane AS, Bei AK, Ahouidi AD, Patel SD, Salinas N, Ndiaye D, Sarr O, Ndir O, Tolia NH, Mboup S, Duraisingh MT
published in: Clinical and vaccine immunology : CVI
information resource reference: Inhibitory humoral responses to the Plasmodium falciparum vaccine candidate EBA-175 are independent of the erythrocyte invasion pathway. Clin Vaccine Immunol. 2013 Aug; 20(8):1238-45.
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Authorship 190716
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linked information resource: Inoculum effect leads to overestimation of in vitro resistance for artemisinin derivatives and standard antimalarials: a Gambian field study.

Authorship 551020
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linked information resource: Erythrocyte-binding antigen 175 mediates invasion in Plasmodium falciparum utilizing sialic acid-dependent and -independent pathways.

Authorship 553396
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author rank in publication: 5
linked author: Duraisingh, Manoj
linked information resource: Functional analysis of epigenetic regulation of tandem RhopH1/clag genes reveals a role in Plasmodium falciparum growth.

Authorship 94451
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author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Transcriptional control and gene silencing in Plasmodium falciparum.

Authorship 225878
type: Authorship
author rank in publication: 4
linked author: Duraisingh, Manoj
linked information resource: High prevalence of mutations in the dihydrofolate reductase gene of Plasmodium falciparum in isolates from Tanzania without evidence of an association to clinical sulfadoxine/pyrimethamine resistance.

Authorship 681012
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linked information resource: Plasmodium falciparum merozoite surface antigen, PfRH5, elicits detectable levels of invasion-inhibiting antibodies in humans.

Plasmodium falciparum merozoite surface antigen, PfRH5, elicits detectable levels of invasion-inhibiting antibodies in humans.
PubMed Identifier: 23904294
author list: Patel SD, Ahouidi AD, Bei AK, Dieye TN, Mboup S, Harrison SC, Duraisingh MT
published in: The Journal of infectious diseases
information resource reference: Plasmodium falciparum merozoite surface antigen, PfRH5, elicits detectable levels of invasion-inhibiting antibodies in humans. J Infect Dis. 2013 Nov 15; 208(10):1679-87.
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Continuous in vitro culture and genetics of Plasmodium vivax in a bespoke blood cell bioreactor
end date: 2028-03-31
principal investigator name: DURAISINGH, MANOJ T
start date: 2025-04-07
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Principal Investigator
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researcher role of: Duraisingh, Manoj
contributes to: Continuous in vitro culture and genetics of Plasmodium vivax in a bespoke blood cell bioreactor

Authorship 1734149
type: Authorship
author rank in publication: 13
linked author: Duraisingh, Manoj
linked information resource: The essential genome of Plasmodium knowlesi reveals determinants of antimalarial susceptibility.

The essential genome of Plasmodium knowlesi reveals determinants of antimalarial susceptibility.
PubMed Identifier: 39913579
author list: Elsworth B, Ye S, Dass S, Tennessen JA, Sultana Q, Thommen BT, Paul AS, Kanjee U, Grüring C, Ferreira MU, Gubbels MJ, Zarringhalam K, Duraisingh MT
published in: Science (New York, N.Y.)
information resource reference: The essential genome of Plasmodium knowlesi reveals determinants of antimalarial susceptibility. Science. 2025 Feb 07; 387(6734):eadq6241.
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Authorship 1746874
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linked author: Duraisingh, Manoj
linked information resource: PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes.

Authorship 1747642
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linked author: Duraisingh, Manoj
linked information resource: PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes.

Authorship 1749517
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author rank in publication: 7
linked author: Duraisingh, Manoj
linked information resource: A Miniaturized Assay to Evaluate Plasmodium cynomolgi and Plasmodium knowlesi as Models for Prioritizing Plasmodium vivax Vaccine Targets.

PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes.
PubMed Identifier: 40343341
author list: Cowman A, Seager B, Lim P, Lai KH, Feufack-Donfack L, Dass S, Xiao X, Jung N, Abraham A, Grigg M, Anstey N, William T, Sattabongkot J, Leis A, Longley R, Duraisingh M, Popovici J, Wilson D, Scally S
published in: Research square
information resource reference: PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes. Res Sq. 2025 Apr 28.
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publication date: 2025-04-28T00:00:00
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A Miniaturized Assay to Evaluate Plasmodium cynomolgi and Plasmodium knowlesi as Models for Prioritizing Plasmodium vivax Vaccine Targets.
PubMed Identifier: 40083318
author list: Dass S, Kundu P, Naskar D, Kanjee U, Ferreira MU, Rayner JC, Duraisingh MT
published in: The Journal of infectious diseases
information resource reference: A Miniaturized Assay to Evaluate Plasmodium cynomolgi and Plasmodium knowlesi as Models for Prioritizing Plasmodium vivax Vaccine Targets. J Infect Dis. 2025 Oct 15; 232(4):912-917.
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publication date: 2025-10-15T00:00:00
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PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes.
PubMed Identifier: 40196582
author list: Seager BA, Lim PS, Lai KH, Feufack-Donfack LB, Dass S, Xiao X, Jung NC, Abraham A, Grigg MJ, Anstey NM, William T, Sattabongkot J, Leis A, Longley RJ, Duraisingh MT, Popovici J, Wilson DW, Scally SW, Cowman AF
published in: bioRxiv : the preprint server for biology
information resource reference: PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes. bioRxiv. 2025 Mar 25.
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Authorship 702054
type: Authorship
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linked author: Duraisingh, Manoj
linked information resource: Antiparasitic chemotherapy: from genomes to mechanisms.

Antiparasitic chemotherapy: from genomes to mechanisms.
PubMed Identifier: 24050701
author list: Horn D, Duraisingh MT
published in: Annual review of pharmacology and toxicology
information resource reference: Antiparasitic chemotherapy: from genomes to mechanisms. Annu Rev Pharmacol Toxicol. 2014; 54:71-94.
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publication date: 2013-09-11T00:00:00
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Authorship 251487
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes by Plasmodium falciparum.

Authorship 172817
type: Authorship
author rank in publication: 46
linked author: Duraisingh, Manoj
linked information resource: Improving malaria control in West Africa: interruption of transmission as a paradigm shift.

Authorship 723168
type: Authorship
author rank in publication: 6
linked author: Duraisingh, Manoj
linked information resource: Human red blood cell-adapted Plasmodium knowlesi parasites: a new model system for malaria research.

Human red blood cell-adapted Plasmodium knowlesi parasites: a new model system for malaria research.
PubMed Identifier: 24506567
author list: Grüring C, Moon RW, Lim C, Holder AA, Blackman MJ, Duraisingh MT
published in: Cellular microbiology
information resource reference: Human red blood cell-adapted Plasmodium knowlesi parasites: a new model system for malaria research. Cell Microbiol. 2014 May; 16(5):612-20.
journal title abbreviation: Cell Microbiol
publication date: 2014-03-12T00:00:00
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type: Academic Article
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Sialyl-T Antigen: A Novel Red Blood Cell Determinant for Plasmodium falciparum Invasion.
PubMed Identifier: 40884048
author list: Mikdar M, Shabani E, Grüring C, Chaand M, Kanjee U, Goldberg JM, Azouzi S, Tennessen JA, Elsworth B, Keutcha C, Barteneva NS, Doench JG, Duraisingh MT
published in: American journal of hematology
information resource reference: Sialyl-T Antigen: A Novel Red Blood Cell Determinant for Plasmodium falciparum Invasion. Am J Hematol. 2025 Nov; 100(11):1952-1962.
journal title abbreviation: Am J Hematol
publication date: 2025-08-29T00:00:00
year: 2025
type: Academic Article
type: Article
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Authorship 250211
type: Authorship
author rank in publication: 12
linked author: Duraisingh, Manoj
linked information resource: A genome-wide map of diversity in Plasmodium falciparum.

Babesia divergens host cell egress is mediated by essential and druggable kinases and proteases.
PubMed Identifier: 41593365
author list: Elsworth B, Keroack CD, Rezvani Y, Paul AS, Barazorda KA, Bauer NC, Tennessen JA, Sack SA, Moreira CK, Gubbels MJ, Meyers MJ, Zarringhalam K, Duraisingh MT
published in: Nature microbiology
information resource reference: Babesia divergens host cell egress is mediated by essential and druggable kinases and proteases. Nat Microbiol. 2026 Feb; 11(2):492-506.
journal title abbreviation: Nat Microbiol
publication date: 2026-01-27T00:00:00
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Authorship 1771176
type: Authorship
author rank in publication: 13
linked author: Duraisingh, Manoj
linked information resource: Sialyl-T Antigen: A Novel Red Blood Cell Determinant for Plasmodium falciparum Invasion.

Authorship 1783043
type: Authorship
author rank in publication: 13
linked author: Duraisingh, Manoj
linked information resource: Babesia divergens host cell egress is mediated by essential and druggable kinases and proteases.

Authorship 1815589
type: Authorship
author rank in publication: 4
linked author: Duraisingh, Manoj
linked information resource: Enhanced detection of malaria infected red blood cells through phase driven classification.

Authorship 1814332
type: Authorship
author rank in publication: 15
linked author: Duraisingh, Manoj
linked information resource: PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes.

Authorship 1816103
type: Authorship
author rank in publication: 17
linked author: Duraisingh, Manoj
linked information resource: A xeno-free red blood cell differentiation formula models sickle cell disease from somatically sourced patient iPSCs.

Authorship 1850074
type: Authorship
author rank in publication: 6
linked author: Duraisingh, Manoj
linked information resource: Ribosomal Architecture and rRNA Modification Landscape in the Tick-Borne Parasite Babesia divergens.

Enhanced detection of malaria infected red blood cells through phase driven classification.
PubMed Identifier: 40841541
author list: Kyeremah C, Paul AS, Haehn D, Duraisingh MT, Yelleswarapu CS
published in: Scientific reports
information resource reference: Enhanced detection of malaria infected red blood cells through phase driven classification. Sci Rep. 2025 Aug 21; 15(1):30733.
journal title abbreviation: Sci Rep
publication date: 2025-08-21T00:00:00
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A xeno-free red blood cell differentiation formula models sickle cell disease from somatically sourced patient iPSCs.
PubMed Identifier: 40957551
author list: Conway AJ, Rosanwo TO, Williamson TE, Landry S, Kinney MA, Clark MA, Vo LT, Rowe RG, Marion W, Zhang Y, Mullin NK, Shi M, Archer NM, Heeney MM, Schlaeger TM, Bauer DE, Duraisingh MT, Brugnara C, North TE, Daley GQ
published in: Experimental hematology
information resource reference: A xeno-free red blood cell differentiation formula models sickle cell disease from somatically sourced patient iPSCs. Exp Hematol. 2025 Dec; 152:105264.
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PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes.
PubMed Identifier: 41587959
author list: Seager BA, Lim PS, Xiao X, Lai KH, Feufack-Donfack LB, Dass S, Jung NC, Abraham A, Grigg MJ, Anstey NM, William T, Sattabongkot J, Leis A, Longley RJ, Duraisingh MT, Popovici J, Wilson DW, Cowman AF, Scally SW
published in: Nature communications
information resource reference: PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytes. Nat Commun. 2026 Jan 26; 17(1):1780.
journal title abbreviation: Nat Commun
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Ribosomal Architecture and rRNA Modification Landscape in the Tick-Borne Parasite Babesia divergens.
PubMed Identifier: 41293005
author list: Gutierrez-Vargas C, Izhaki-Tavor LS, Calvopina-Chavez D, Keroack CD, Copello P, Duraisingh MT, Léger-Abraham M
published in: bioRxiv : the preprint server for biology
information resource reference: Ribosomal Architecture and rRNA Modification Landscape in the Tick-Borne Parasite Babesia divergens. bioRxiv. 2025 Nov 11.
journal title abbreviation: bioRxiv
publication date: 2025-11-11T00:00:00
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type: Academic Article
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Authorship 741489
type: Authorship
author rank in publication: 12
linked author: Duraisingh, Manoj
linked information resource: STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediates merozoite invasion and rosetting.

Authorship 742926
type: Authorship
author rank in publication: 11
linked author: Duraisingh, Manoj
linked information resource: Plasmodium falciparum transmission stages accumulate in the human bone marrow.

Plasmodium falciparum transmission stages accumulate in the human bone marrow.
PubMed Identifier: 25009232
author list: Joice R, Nilsson SK, Montgomery J, Dankwa S, Egan E, Morahan B, Seydel KB, Bertuccini L, Alano P, Williamson KC, Duraisingh MT, Taylor TE, Milner DA, Marti M
published in: Science translational medicine
information resource reference: Plasmodium falciparum transmission stages accumulate in the human bone marrow. Sci Transl Med. 2014 Jul 09; 6(244):244re5.
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publication date: 2014-07-09T00:00:00
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STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediates merozoite invasion and rosetting.
PubMed Identifier: 25011110
author list: Niang M, Bei AK, Madnani KG, Pelly S, Dankwa S, Kanjee U, Gunalan K, Amaladoss A, Yeo KP, Bob NS, Malleret B, Duraisingh MT, Preiser PR
published in: Cell host & microbe
information resource reference: STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediates merozoite invasion and rosetting. Cell Host Microbe. 2014 Jul 09; 16(1):81-93.
journal title abbreviation: Cell Host Microbe
publication date: 2014-07-09T00:00:00
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type: Academic Article
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Authorship 43255
type: Authorship
author rank in publication: 1
linked author: Duraisingh, Manoj
linked information resource: Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum.

Richard Pearson Strong Professor of Infectious Diseases
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Associate Professor of Pediatrics
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Research Scientist
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Visiting Scientist
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Research Scientist
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John LaPorte Given Professor of Immunology and Infectious Diseases
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Research Associate
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Visiting Scientist
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Associate Professor of Immunology and Infectious Diseases
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Department Associate
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Authorship 475470
type: Authorship
author rank in publication: 6
linked author: Duraisingh, Manoj
linked information resource: Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes.

Authorship 747485
type: Authorship
author rank in publication: 13
linked author: Duraisingh, Manoj
linked information resource: A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion.

Authorship 750784
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Editorial overview: Host-microbe interactions: parasites: sensing and responding to the changing environment: the life of protozoan parasites.

Editorial overview: Host-microbe interactions: parasites: sensing and responding to the changing environment: the life of protozoan parasites.
PubMed Identifier: 25081632
author list: Guillén N, Duraisingh M
published in: Current opinion in microbiology
information resource reference: Editorial overview: Host-microbe interactions: parasites: sensing and responding to the changing environment: the life of protozoan parasites. Curr Opin Microbiol. 2014 Aug; 20:vii-ix.
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A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion.
PubMed Identifier: 25121747
author list: Coleman BI, Skillman KM, Jiang RHY, Childs LM, Altenhofen LM, Ganter M, Leung Y, Goldowitz I, Kafsack BFC, Marti M, Llinás M, Buckee CO, Duraisingh MT
published in: Cell host & microbe
information resource reference: A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion. Cell Host Microbe. 2014 Aug 13; 16(2):177-186.
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Authorship 40926
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Unravelling a histone code for malaria virulence.

Authorship 778527
type: Authorship
author rank in publication: 8
linked author: Duraisingh, Manoj
linked information resource: Enrichment of reticulocytes from whole blood using aqueous multiphase systems of polymers.

Enrichment of reticulocytes from whole blood using aqueous multiphase systems of polymers.
PubMed Identifier: 25263455
author list: Kumar AA, Lim C, Moreno Y, Mace CR, Syed A, Van Tyne D, Wirth DF, Duraisingh MT, Whitesides GM
published in: American journal of hematology
information resource reference: Enrichment of reticulocytes from whole blood using aqueous multiphase systems of polymers. Am J Hematol. 2015 Jan; 90(1):31-6.
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publication date: 2014-10-18T00:00:00
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Authorship 554899
type: Authorship
author rank in publication: 1
linked author: Duraisingh, Manoj
linked information resource: Contribution of the pfmdr1 gene to antimalarial drug-resistance.

Authorship 564848
type: Authorship
author rank in publication: 6
linked author: Duraisingh, Manoj
linked information resource: Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3.

Authorship 380631
type: Authorship
author rank in publication: 7
linked author: Duraisingh, Manoj
linked information resource: Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene.

Authorship 381265
type: Authorship
author rank in publication: 5
linked author: Duraisingh, Manoj
linked information resource: Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii.

Authorship 428270
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Analysis of pfcrt, pfmdr1, dhfr, and dhps mutations and drug sensitivities in Plasmodium falciparum isolates from patients in Vietnam before and after treatment with artemisinin.

Authorship 505833
type: Authorship
author rank in publication: 10
linked author: Duraisingh, Manoj
linked information resource: A flow cytometry-based assay for measuring invasion of red blood cells by Plasmodium falciparum.

Authorship 542153
type: Authorship
author rank in publication: 1
linked author: Duraisingh, Manoj
linked information resource: Plasmodium falciparum: detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion.

Authorship 543329
type: Authorship
author rank in publication: 1
linked author: Duraisingh, Manoj
linked information resource: Plasmodium research in the postgenomic era.

Authorship 226409
type: Authorship
author rank in publication: 1
linked author: Duraisingh, Manoj
linked information resource: Sickle cell microRNAs inhibit the malaria parasite.

Authorship 524523
type: Authorship
author rank in publication: 1
linked author: Duraisingh, Manoj
linked information resource: The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin.

Authorship 540321
type: Authorship
author rank in publication: 8
linked author: Duraisingh, Manoj
linked information resource: Epigenetic dysregulation of virulence gene expression in severe Plasmodium falciparum malaria.

Authorship 55068
type: Authorship
author rank in publication: 3
linked author: Duraisingh, Manoj
linked information resource: In vitro genetic analysis of an erythrocyte determinant of malaria infection.

Authorship 556288
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Functional analysis of erythrocyte determinants of Plasmodium infection.

Authorship 66857
type: Authorship
author rank in publication: 13
linked author: Duraisingh, Manoj
linked information resource: A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes.

Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion.
PubMed Identifier: 25954012
author list: Egan ES, Jiang RH, Moechtar MA, Barteneva NS, Weekes MP, Nobre LV, Gygi SP, Paulo JA, Frantzreb C, Tani Y, Takahashi J, Watanabe S, Goldberg J, Paul AS, Brugnara C, Root DE, Wiegand RC, Doench JG, Duraisingh MT
published in: Science (New York, N.Y.)
information resource reference: Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion. Science. 2015 May 08; 348(6235):711-4.
journal title abbreviation: Science
publication date: 2015-05-08T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 243101
type: Authorship
author rank in publication: 5
linked author: Duraisingh, Manoj
linked information resource: A novel erythrocyte binding antigen-175 paralogue from Plasmodium falciparum defines a new trypsin-resistant receptor on human erythrocytes.

Authorship 271191
type: Authorship
author rank in publication: 10
linked author: Duraisingh, Manoj
linked information resource: Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial.

Authorship 255075
type: Authorship
author rank in publication: 16
linked author: Duraisingh, Manoj
linked information resource: Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.

Authorship 276049
type: Authorship
author rank in publication: 3
linked author: Duraisingh, Manoj
linked information resource: Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development.

Authorship 301539
type: Authorship
author rank in publication: 8
linked author: Duraisingh, Manoj
linked information resource: Variant merozoite protein expression is associated with erythrocyte invasion phenotypes in Plasmodium falciparum isolates from Tanzania.

Authorship 423873
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Heterochromatin-mediated control of virulence gene expression.

Authorship 469914
type: Authorship
author rank in publication: 5
linked author: Duraisingh, Manoj
linked information resource: Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors.

Authorship 424456
type: Authorship
author rank in publication: 12
linked author: Duraisingh, Manoj
linked information resource: Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens.

Authorship 437263
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Direct evidence that asparagine at position 108 of the Plasmodium falciparum dihydrofolate reductase is involved in resistance to antifolate drugs in Tanzania.

Authorship 461649
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations.

Authorship 806243
type: Authorship
author rank in publication: 9
linked author: Duraisingh, Manoj
linked information resource: Dietary restriction protects against experimental cerebral malaria via leptin modulation and T-cell mTORC1 suppression.

Authorship 793185
type: Authorship
author rank in publication: 8
linked author: Duraisingh, Manoj
linked information resource: Functional analysis of sirtuin genes in multiple Plasmodium falciparum strains.

Authorship 794281
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: From Protease to Decarboxylase: THE MOLECULAR METAMORPHOSIS OF PHOSPHATIDYLSERINE DECARBOXYLASE.

Authorship 793848
type: Authorship
author rank in publication: 19
linked author: Duraisingh, Manoj
linked information resource: Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion.

Authorship 806174
type: Authorship
author rank in publication: 3
linked author: Duraisingh, Manoj
linked information resource: Host-parasite interactions that guide red blood cell invasion by malaria parasites.

Host-parasite interactions that guide red blood cell invasion by malaria parasites.
PubMed Identifier: 25767956
author list: Paul AS, Egan ES, Duraisingh MT
published in: Current opinion in hematology
information resource reference: Host-parasite interactions that guide red blood cell invasion by malaria parasites. Curr Opin Hematol. 2015 May; 22(3):220-6.
journal title abbreviation: Curr Opin Hematol
publication date: 2015-05-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Dietary restriction protects against experimental cerebral malaria via leptin modulation and T-cell mTORC1 suppression.
PubMed Identifier: 25636003
author list: Mejia P, Treviño-Villarreal JH, Hine C, Harputlugil E, Lang S, Calay E, Rogers R, Wirth D, Duraisingh MT, Mitchell JR
published in: Nature communications
information resource reference: Dietary restriction protects against experimental cerebral malaria via leptin modulation and T-cell mTORC1 suppression. Nat Commun. 2015 Jan 30; 6:6050.
journal title abbreviation: Nat Commun
publication date: 2015-01-30T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

From Protease to Decarboxylase: THE MOLECULAR METAMORPHOSIS OF PHOSPHATIDYLSERINE DECARBOXYLASE.
PubMed Identifier: 25724650
author list: Choi JY, Duraisingh MT, Marti M, Ben Mamoun C, Voelker DR
published in: The Journal of biological chemistry
information resource reference: From Protease to Decarboxylase: THE MOLECULAR METAMORPHOSIS OF PHOSPHATIDYLSERINE DECARBOXYLASE. J Biol Chem. 2015 Apr 24; 290(17):10972-80.
journal title abbreviation: J Biol Chem
publication date: 2015-02-26T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Functional analysis of sirtuin genes in multiple Plasmodium falciparum strains.
PubMed Identifier: 25780929
author list: Merrick CJ, Jiang RH, Skillman KM, Samarakoon U, Moore RM, Dzikowski R, Ferdig MT, Duraisingh MT
published in: PloS one
information resource reference: Functional analysis of sirtuin genes in multiple Plasmodium falciparum strains. PLoS One. 2015; 10(3):e0118865.
journal title abbreviation: PLoS One
publication date: 2015-03-17T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 294786
type: Authorship
author rank in publication: 10
linked author: Duraisingh, Manoj
linked information resource: Molecular analysis of erythrocyte invasion in Plasmodium falciparum isolates from Senegal.

Authorship 384662
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment.

Authorship 541178
type: Authorship
author rank in publication: 8
linked author: Duraisingh, Manoj
linked information resource: A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis.

Authorship 544341
type: Authorship
author rank in publication: 6
linked author: Duraisingh, Manoj
linked information resource: Polymorphisms in the dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) genes of Plasmodium falciparum and in vivo resistance to sulphadoxine/pyrimethamine in isolates from Tanzania.

Authorship 370885
type: Authorship
author rank in publication: 1
linked author: Duraisingh, Manoj
linked information resource: Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum.

Authorship 422090
type: Authorship
author rank in publication: 1
linked author: Duraisingh, Manoj
linked information resource: Evidence for selection for the tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum by chloroquine and amodiaquine.

Authorship 432173
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: An old enemy, a new battle plan. Perspective on combating drug-resistant malaria.

Authorship 813838
type: Authorship
author rank in publication: 12
linked author: Duraisingh, Manoj
linked information resource: Parasite Calcineurin Regulates Host Cell Recognition and Attachment by Apicomplexans.

Parasite Calcineurin Regulates Host Cell Recognition and Attachment by Apicomplexans.
PubMed Identifier: 26118996
author list: Paul AS, Saha S, Engelberg K, Jiang RH, Coleman BI, Kosber AL, Chen CT, Ganter M, Espy N, Gilberger TW, Gubbels MJ, Duraisingh MT
published in: Cell host & microbe
information resource reference: Parasite Calcineurin Regulates Host Cell Recognition and Attachment by Apicomplexans. Cell Host Microbe. 2015 Jul 08; 18(1):49-60.
journal title abbreviation: Cell Host Microbe
publication date: 2015-06-25T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 332518
type: Authorship
author rank in publication: 4
linked author: Duraisingh, Manoj
linked information resource: The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand.

Authorship 361151
type: Authorship
author rank in publication: 6
linked author: Duraisingh, Manoj
linked information resource: The effect of Plasmodium falciparum Sir2a histone deacetylase on clonal and longitudinal variation in expression of the var family of virulence genes.

Authorship 45234
type: Authorship
author rank in publication: 3
linked author: Duraisingh, Manoj
linked information resource: Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum.

Authorship 835998
type: Authorship
author rank in publication: 7
linked author: Duraisingh, Manoj
linked information resource: Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach.

Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach.
PubMed Identifier: 26259939
author list: Wassmer SC, Taylor TE, Rathod PK, Mishra SK, Mohanty S, Arevalo-Herrera M, Duraisingh MT, Smith JD
published in: The American journal of tropical medicine and hygiene
information resource reference: Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach. Am J Trop Med Hyg. 2015 Sep; 93(3 Suppl):42-56.
journal title abbreviation: Am J Trop Med Hyg
publication date: 2015-08-10T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 376759
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Evolution of apicomplexan secretory organelles.

Authorship 839226
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Measuring Plasmodium falciparum Erythrocyte Invasion Phenotypes Using Flow Cytometry.

Measuring Plasmodium falciparum Erythrocyte Invasion Phenotypes Using Flow Cytometry.
PubMed Identifier: 26450388
author list: Bei AK, Duraisingh MT
published in: Methods in molecular biology (Clifton, N.J.)
information resource reference: Measuring Plasmodium falciparum Erythrocyte Invasion Phenotypes Using Flow Cytometry. Methods Mol Biol. 2015; 1325:167-86.
journal title abbreviation: Methods Mol Biol
publication date: 2015-01-01T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 845179
type: Authorship
author rank in publication: 12
linked author: Duraisingh, Manoj
linked information resource: Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi.

Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi.
PubMed Identifier: 26438871
author list: Assefa S, Lim C, Preston MD, Duffy CW, Nair MB, Adroub SA, Kadir KA, Goldberg JM, Neafsey DE, Divis P, Clark TG, Duraisingh MT, Conway DJ, Pain A, Singh B
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi. Proc Natl Acad Sci U S A. 2015 Oct 20; 112(42):13027-32.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2015-10-05T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 513557
type: Authorship
author rank in publication: 22
linked author: Duraisingh, Manoj
linked information resource: Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model.

Authorship 855426
type: Authorship
author rank in publication: 8
linked author: Duraisingh, Manoj
linked information resource: The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity.

The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity.
PubMed Identifier: 26459896
author list: Tubman VN, Mejia P, Shmukler BE, Bei AK, Alper SL, Mitchell JR, Brugnara C, Duraisingh MT
published in: Antimicrobial agents and chemotherapy
information resource reference: The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity. Antimicrob Agents Chemother. 2016 01; 60(1):613-6.
journal title abbreviation: Antimicrob Agents Chemother
publication date: 2015-10-12T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 504549
type: Authorship
author rank in publication: 4
linked author: Duraisingh, Manoj
linked information resource: Resistance to antiparasitic drugs: the role of molecular diagnosis.

Genetic analysis of how Duffy antigen expression level affects erythrocyte susceptibility to vivax malaria infection
end date: 2011-08-12T00:00:00
start date: 2011-06-20T00:00:00
type: Mentoring - Completed Student Project
overview: Summer

Authorship 8316
type: Authorship
author rank in publication: 10
linked author: Duraisingh, Manoj
linked information resource: Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum.

Authorship 88404
type: Authorship
author rank in publication: 1
linked author: Duraisingh, Manoj
linked information resource: Linkage disequilibrium between two chromosomally distinct loci associated with increased resistance to chloroquine in Plasmodium falciparum.

Authorship 866321
type: Authorship
author rank in publication: 12
linked author: Duraisingh, Manoj
linked information resource: Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model.

Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model.
PubMed Identifier: 26880111
author list: Obaldía N, Dow GS, Gerena L, Kyle D, Otero W, Mantel PY, Baro N, Daniels R, Mukherjee A, Childs LM, Buckee C, Duraisingh MT, Volkman SK, Wirth DF, Marti M
published in: Scientific reports
information resource reference: Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model. Sci Rep. 2016 Feb 16; 6:21216.
journal title abbreviation: Sci Rep
publication date: 2016-02-16T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 875757
type: Authorship
author rank in publication: 11
linked author: Duraisingh, Manoj
linked information resource: Ancient human sialic acid variant restricts an emerging zoonotic malaria parasite.

Authorship 874027
type: Authorship
author rank in publication: 7
linked author: Duraisingh, Manoj
linked information resource: Evidence for spleen dysfunction in malaria-HIV co-infection in a subset of pediatric patients.

Authorship 874945
type: Authorship
author rank in publication: 8
linked author: Duraisingh, Manoj
linked information resource: Malaria Vaccine Development: Focusing Field Erythrocyte Invasion Studies on Phenotypic Diversity: The West African Merozoite Invasion Network (WAMIN).

Malaria Vaccine Development: Focusing Field Erythrocyte Invasion Studies on Phenotypic Diversity: The West African Merozoite Invasion Network (WAMIN).
PubMed Identifier: 26725306
author list: Ahouidi AD, Amambua-Ngwa A, Awandare GA, Bei AK, Conway DJ, Diakite M, Duraisingh MT, Rayner JC, Zenonos ZA
published in: Trends in parasitology
information resource reference: Malaria Vaccine Development: Focusing Field Erythrocyte Invasion Studies on Phenotypic Diversity: The West African Merozoite Invasion Network (WAMIN). Trends Parasitol. 2016 Apr; 32(4):274-283.
journal title abbreviation: Trends Parasitol
publication date: 2015-12-23T00:00:00
year: 2015
type: Academic Article
type: Article
type: Document
type: Information Resource

Evidence for spleen dysfunction in malaria-HIV co-infection in a subset of pediatric patients.
PubMed Identifier: 26916076
author list: Joice R, Frantzreb C, Pradham A, Seydel KB, Kamiza S, Wirth DF, Duraisingh MT, Molyneux ME, Taylor TE, Marti M, Milner DA
published in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
information resource reference: Evidence for spleen dysfunction in malaria-HIV co-infection in a subset of pediatric patients. Mod Pathol. 2016 Apr; 29(4):381-90.
journal title abbreviation: Mod Pathol
publication date: 2016-02-26T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Ancient human sialic acid variant restricts an emerging zoonotic malaria parasite.
PubMed Identifier: 27041489
author list: Dankwa S, Lim C, Bei AK, Jiang RH, Abshire JR, Patel SD, Goldberg JM, Moreno Y, Kono M, Niles JC, Duraisingh MT
published in: Nature communications
information resource reference: Ancient human sialic acid variant restricts an emerging zoonotic malaria parasite. Nat Commun. 2016 Apr 04; 7:11187.
journal title abbreviation: Nat Commun
publication date: 2016-04-04T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 43356
type: Authorship
author rank in publication: 4
linked author: Duraisingh, Manoj
linked information resource: Malaria evolution in South Asia: knowledge for control and elimination.

Authorship 879789
type: Authorship
author rank in publication: 10
linked author: Duraisingh, Manoj
linked information resource: Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signaling.

Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signaling.
PubMed Identifier: 26933036
author list: Sidik SM, Hortua Triana MA, Paul AS, El Bakkouri M, Hackett CG, Tran F, Westwood NJ, Hui R, Zuercher WJ, Duraisingh MT, Moreno SN, Lourido S
published in: The Journal of biological chemistry
information resource reference: Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signaling. J Biol Chem. 2016 Apr 29; 291(18):9566-80.
journal title abbreviation: J Biol Chem
publication date: 2016-03-01T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 490502
type: Authorship
author rank in publication: 5
linked author: Duraisingh, Manoj
linked information resource: A genetic screen for improved plasmid segregation reveals a role for Rep20 in the interaction of Plasmodium falciparum chromosomes.

Authorship 882251
type: Authorship
author rank in publication: 1
linked author: Duraisingh, Manoj
linked information resource: Epigenetic Regulation of Virulence Gene Expression in Parasitic Protozoa.

Epigenetic Regulation of Virulence Gene Expression in Parasitic Protozoa.
PubMed Identifier: 27173931
author list: Duraisingh MT, Horn D
published in: Cell host & microbe
information resource reference: Epigenetic Regulation of Virulence Gene Expression in Parasitic Protozoa. Cell Host Microbe. 2016 May 11; 19(5):629-40.
journal title abbreviation: Cell Host Microbe
publication date: 2016-05-11T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Associate Professor
sort order: 1
type: Faculty Rank

Full Professor
sort order: 0
type: Faculty Rank

Other Faculty
sort order: 5
type: Faculty Rank

Authorship 88103
type: Authorship
author rank in publication: 10
linked author: Duraisingh, Manoj
linked information resource: Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal.

Authorship 891243
type: Authorship
author rank in publication: 13
linked author: Duraisingh, Manoj
linked information resource: Improved light microscopy counting method for accurately counting Plasmodium parasitemia and reticulocytemia.

Improved light microscopy counting method for accurately counting Plasmodium parasitemia and reticulocytemia.
PubMed Identifier: 27074559
author list: Lim C, Pereira L, Shardul P, Mascarenhas A, Maki J, Rixon J, Shaw-Saliba K, White J, Silveira M, Gomes E, Chery L, Rathod PK, Duraisingh MT
published in: American journal of hematology
information resource reference: Improved light microscopy counting method for accurately counting Plasmodium parasitemia and reticulocytemia. Am J Hematol. 2016 08; 91(8):852-5.
journal title abbreviation: Am J Hematol
publication date: 2016-05-24T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 894795
type: Authorship
author rank in publication: 9
linked author: Duraisingh, Manoj
linked information resource: Insights into an Optimization of Plasmodium vivax Sal-1 In Vitro Culture: The Aotus Primate Model.

Authorship 894318
type: Authorship
author rank in publication: 5
linked author: Duraisingh, Manoj
linked information resource: Extensive Shared Chemosensitivity between Malaria and Babesiosis Blood-Stage Parasites.

Extensive Shared Chemosensitivity between Malaria and Babesiosis Blood-Stage Parasites.
PubMed Identifier: 27246780
author list: Paul AS, Moreira CK, Elsworth B, Allred DR, Duraisingh MT
published in: Antimicrobial agents and chemotherapy
information resource reference: Extensive Shared Chemosensitivity between Malaria and Babesiosis Blood-Stage Parasites. Antimicrob Agents Chemother. 2016 08; 60(8):5059-63.
journal title abbreviation: Antimicrob Agents Chemother
publication date: 2016-07-22T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Insights into an Optimization of Plasmodium vivax Sal-1 In Vitro Culture: The Aotus Primate Model.
PubMed Identifier: 27463518
author list: Shaw-Saliba K, Thomson-Luque R, Obaldía N, Nuñez M, Dutary S, Lim C, Barnes S, Kocken CH, Duraisingh MT, Adams JH, Pasini EM
published in: PLoS neglected tropical diseases
information resource reference: Insights into an Optimization of Plasmodium vivax Sal-1 In Vitro Culture: The Aotus Primate Model. PLoS Negl Trop Dis. 2016 07; 10(7):e0004870.
journal title abbreviation: PLoS Negl Trop Dis
publication date: 2016-07-27T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 59986
type: Authorship
author rank in publication: 1
linked author: Duraisingh, Manoj
linked information resource: Erythrocyte invasion by Plasmodium falciparum: multiple ligand-receptor interactions and phenotypic switching.

Authorship 90542
type: Authorship
author rank in publication: 1
linked author: Duraisingh, Manoj
linked information resource: Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes.

Authorship 554784
type: Authorship
author rank in publication: 10
linked author: Duraisingh, Manoj
linked information resource: Cooperativity between Plasmodium falciparum adhesive proteins for invasion into erythrocytes.

Molecular analysis of erythrocyte invasion in malaria isolates from Senegal
end date: 2012-12-31
principal investigator name: DURAISINGH, MANOJ T
start date: 2009-02-01
type: Grant
sponsor award id: R03TW008053

Genetic screens for erythrocyte determinants of protein trafficking in malaria parasites
end date: 2018-05-31
principal investigator name: DURAISINGH, MANOJ T
start date: 2016-06-02
type: Grant
sponsor award id: R21AI126889

Functional analysis of Plasmodium vivax drug resistance polymorphisms
end date: 2018-11-30
principal investigator name: DURAISINGH, MANOJ T
start date: 2016-06-01
type: Grant
sponsor award id: R21AI126154

Genetic validation of essential asexual stage genes in Plasmodium falciparum
end date: 2013-04-30
principal investigator name: DURAISINGH, MANOJ T
start date: 2010-05-06
type: Grant
sponsor award id: R21AI088314

Functional analysis of erythrocyte determinants of malaria infection
end date: 2017-04-30
principal investigator name: DURAISINGH, MANOJ T
start date: 2011-05-01
type: Grant
sponsor award id: R01AI091787

Forward genetic screens for identifying antimalarial resistance genes
end date: 2012-06-30
principal investigator name: DURAISINGH, MANOJ T
start date: 2009-07-20
type: Grant
sponsor award id: R21AI082309

Erythrocyte invasion by Plasmodium falciparum merozoites
end date: 2010-04-30
principal investigator name: DURAISINGH, MANOJ T
start date: 2004-05-15
type: Grant
sponsor award id: R01AI057919

Principal Investigator
type: Researcher Role
researcher role of: Duraisingh, Manoj
contributes to: Functional analysis of erythrocyte determinants of malaria infection

Principal Investigator
type: Researcher Role
researcher role of: Duraisingh, Manoj
contributes to: Functional analysis of Plasmodium vivax drug resistance polymorphisms

Principal Investigator
type: Researcher Role
researcher role of: Duraisingh, Manoj
contributes to: Forward genetic screens for identifying antimalarial resistance genes

Principal Investigator
type: Researcher Role
researcher role of: Duraisingh, Manoj
contributes to: Erythrocyte invasion by Plasmodium falciparum merozoites

Principal Investigator
type: Researcher Role
researcher role of: Duraisingh, Manoj
contributes to: Genetic validation of essential asexual stage genes in Plasmodium falciparum

Principal Investigator
type: Researcher Role
researcher role of: Duraisingh, Manoj
contributes to: Molecular analysis of erythrocyte invasion in malaria isolates from Senegal

Principal Investigator
type: Researcher Role
researcher role of: Duraisingh, Manoj
contributes to: Genetic screens for erythrocyte determinants of protein trafficking in malaria parasites

Authorship 915161
type: Authorship
author rank in publication: 9
linked author: Duraisingh, Manoj
linked information resource: Reticulocyte Preference and Stage Development of Plasmodium vivax Isolates.

Reticulocyte Preference and Stage Development of Plasmodium vivax Isolates.
PubMed Identifier: 27432121
author list: Lim C, Pereira L, Saliba KS, Mascarenhas A, Maki JN, Chery L, Gomes E, Rathod PK, Duraisingh MT
published in: The Journal of infectious diseases
information resource reference: Reticulocyte Preference and Stage Development of Plasmodium vivax Isolates. J Infect Dis. 2016 10 01; 214(7):1081-4.
journal title abbreviation: J Infect Dis
publication date: 2016-07-17T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 915936
type: Authorship
author rank in publication: 14
linked author: Duraisingh, Manoj
linked information resource: Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates.

Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates.
PubMed Identifier: 27456552
author list: Shaw-Saliba K, Clarke D, Santos JM, Menezes MJ, Lim C, Mascarenhas A, Chery L, Gomes E, March S, Bhatia SN, Rathod PK, Ferreira MU, Catteruccia F, Duraisingh MT
published in: International journal for parasitology
information resource reference: Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates. Int J Parasitol. 2016 10; 46(11):679-83.
journal title abbreviation: Int J Parasitol
publication date: 2016-07-25T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 95005
type: Authorship
author rank in publication: 8
linked author: Duraisingh, Manoj
linked information resource: Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.

Authorship 320108
type: Authorship
author rank in publication: 3
linked author: Duraisingh, Manoj
linked information resource: Identification and disruption of the gene encoding the third member of the low-molecular-mass rhoptry complex in Plasmodium falciparum.

Authorship 396390
type: Authorship
author rank in publication: 9
linked author: Duraisingh, Manoj
linked information resource: Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans.

665 Huntington Ave
type: Address
address line 1: Harvard School of Public Health
address line 2: FXB Rm 205
address line 3: 665 Huntington Ave
city: Boston
postal code: 02115
state or province: MA

Authorship 920629
type: Authorship
author rank in publication: 15
linked author: Duraisingh, Manoj
linked information resource: Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria.

Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria.
PubMed Identifier: 27721445
author list: Mantel PY, Hjelmqvist D, Walch M, Kharoubi-Hess S, Nilsson S, Ravel D, Ribeiro M, Grüring C, Ma S, Padmanabhan P, Trachtenberg A, Ankarklev J, Brancucci NM, Huttenhower C, Duraisingh MT, Ghiran I, Kuo WP, Filgueira L, Martinelli R, Marti M
published in: Nature communications
information resource reference: Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria. Nat Commun. 2016 10 10; 7:12727.
journal title abbreviation: Nat Commun
publication date: 2016-10-10T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 432253
type: Authorship
author rank in publication: 4
linked author: Duraisingh, Manoj
linked information resource: Genetic analysis of the cytoplasmic domain of the PfRh2b merozoite invasion protein of Plasmodium falciparum.

Authorship 930887
type: Authorship
author rank in publication: 15
linked author: Duraisingh, Manoj
linked information resource: Independent Origin and Global Distribution of Distinct Plasmodium vivax Duffy Binding Protein Gene Duplications.

Authorship 935830
type: Authorship
author rank in publication: 12
linked author: Duraisingh, Manoj
linked information resource: Distinct genomic architecture of Plasmodium falciparum populations from South Asia.

Independent Origin and Global Distribution of Distinct Plasmodium vivax Duffy Binding Protein Gene Duplications.
PubMed Identifier: 27798646
author list: Hostetler JB, Lo E, Kanjee U, Amaratunga C, Suon S, Sreng S, Mao S, Yewhalaw D, Mascarenhas A, Kwiatkowski DP, Ferreira MU, Rathod PK, Yan G, Fairhurst RM, Duraisingh MT, Rayner JC
published in: PLoS neglected tropical diseases
information resource reference: Independent Origin and Global Distribution of Distinct Plasmodium vivax Duffy Binding Protein Gene Duplications. PLoS Negl Trop Dis. 2016 Oct; 10(10):e0005091.
journal title abbreviation: PLoS Negl Trop Dis
publication date: 2016-10-31T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Distinct genomic architecture of Plasmodium falciparum populations from South Asia.
PubMed Identifier: 27457272
author list: Kumar S, Mudeppa DG, Sharma A, Mascarenhas A, Dash R, Pereira L, Shaik RB, Maki JN, White J, Zuo W, Tuljapurkar S, Duraisingh MT, Gomes E, Chery L, Rathod PK
published in: Molecular and biochemical parasitology
information resource reference: Distinct genomic architecture of Plasmodium falciparum populations from South Asia. Mol Biochem Parasitol. 2016 Nov - Dec; 210(1-2):1-4.
journal title abbreviation: Mol Biochem Parasitol
publication date: 2016-07-22T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 80891
type: Authorship
author rank in publication: 1
linked author: Duraisingh, Manoj
linked information resource: Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination.

Authorship 83865
type: Authorship
author rank in publication: 12
linked author: Duraisingh, Manoj
linked information resource: Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.

Authorship 938453
type: Authorship
author rank in publication: 33
linked author: Duraisingh, Manoj
linked information resource: Demographic and clinical profiles of Plasmodium falciparum and Plasmodium vivax patients at a tertiary care centre in southwestern India.

Demographic and clinical profiles of Plasmodium falciparum and Plasmodium vivax patients at a tertiary care centre in southwestern India.
PubMed Identifier: 27884146
author list: Chery L, Maki JN, Mascarenhas A, Walke JT, Gawas P, Almeida A, Fernandes M, Vaz M, Ramanan R, Shirodkar D, Bernabeu M, Manoharan SK, Pereira L, Dash R, Sharma A, Shaik RB, Chakrabarti R, Babar P, White J, Mudeppa DG, Kumar S, Zuo W, Skillman KM, Kanjee U, Lim C, Shaw-Saliba K, Kumar A, Valecha N, Jindal VN, Khandeparkar A, Naik P, Amonkar S, Duraisingh MT, Tuljapurkar S, Smith JD, Dubhashi N, Pinto RG, Silveria M, Gomes E, Rathod PK
published in: Malaria journal
information resource reference: Demographic and clinical profiles of Plasmodium falciparum and Plasmodium vivax patients at a tertiary care centre in southwestern India. Malar J. 2016 11 25; 15(1):569.
journal title abbreviation: Malar J
publication date: 2016-11-25T00:00:00
year: 2016
type: Academic Article
type: Article
type: Document
type: Information Resource

Chemical genetic screening to identify synergistic inhibitors of malaria parasite cell cycle regulators
end date: 2019-05-31
principal investigator name: DURAISINGH, MANOJ T
start date: 2016-12-15
type: Grant
sponsor award id: R21AI128480

Principal Investigator
type: Researcher Role
researcher role of: Duraisingh, Manoj
contributes to: Chemical genetic screening to identify synergistic inhibitors of malaria parasite cell cycle regulators

Authorship 89705
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Rational use of drugs against Plasmodium falciparum.

Authorship 90254
type: Authorship
author rank in publication: 4
linked author: Duraisingh, Manoj
linked information resource: Antisense RNA and RNAi in protozoan parasites: working hard or hardly working?

Authorship 93804
type: Authorship
author rank in publication: 17
linked author: Duraisingh, Manoj
linked information resource: Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.

Authorship 958645
type: Authorship
author rank in publication: 4
linked author: Duraisingh, Manoj
linked information resource: Host Cell Tropism and Adaptation of Blood-Stage Malaria Parasites: Challenges for Malaria Elimination.

Host Cell Tropism and Adaptation of Blood-Stage Malaria Parasites: Challenges for Malaria Elimination.
PubMed Identifier: 28213436
author list: Lim C, Dankwa S, Paul AS, Duraisingh MT
published in: Cold Spring Harbor perspectives in medicine
information resource reference: Host Cell Tropism and Adaptation of Blood-Stage Malaria Parasites: Challenges for Malaria Elimination. Cold Spring Harb Perspect Med. 2017 Nov 01; 7(11).
journal title abbreviation: Cold Spring Harb Perspect Med
publication date: 2017-11-01T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Direct evidence that asparagine at position 108 of the Plasmodium falciparum dihydrofolate reductase is involved in resistance to antifolate drugs in Tanzania.
PubMed Identifier: 9015515
author list: Curtis J, Duraisingh MT, Trigg JK, Mbwana H, Warhurst DC, Curtis CF
published in: Transactions of the Royal Society of Tropical Medicine and Hygiene
information resource reference: Direct evidence that asparagine at position 108 of the Plasmodium falciparum dihydrofolate reductase is involved in resistance to antifolate drugs in Tanzania. Trans R Soc Trop Med Hyg. 1996 Nov-Dec; 90(6):678-80.
journal title abbreviation: Trans R Soc Trop Med Hyg
publication date: 1996-11-01T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial.
PubMed Identifier: 10665554
author list: von Seidlein L, Milligan P, Pinder M, Bojang K, Anyalebechi C, Gosling R, Coleman R, Ude JI, Sadiq A, Duraisingh M, Warhurst D, Alloueche A, Targett G, McAdam K, Greenwood B, Walraven G, Olliaro P, Doherty T
published in: Lancet (London, England)
information resource reference: Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial. Lancet. 2000 Jan 29; 355(9201):352-7.
journal title abbreviation: Lancet
publication date: 2000-01-29T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Linkage disequilibrium between two chromosomally distinct loci associated with increased resistance to chloroquine in Plasmodium falciparum.
PubMed Identifier: 11085219
author list: Duraisingh MT, von Seidlein LV, Jepson A, Jones P, Sambou I, Pinder M, Warhurst DC
published in: Parasitology
information resource reference: Linkage disequilibrium between two chromosomally distinct loci associated with increased resistance to chloroquine in Plasmodium falciparum. Parasitology. 2000 Jul; 121 ( Pt 1):1-7.
journal title abbreviation: Parasitology
publication date: 2000-07-01T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 966751
type: Authorship
author rank in publication: 15
linked author: Duraisingh, Manoj
linked information resource: Erratum: Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony.

Authorship 969407
type: Authorship
author rank in publication: 15
linked author: Duraisingh, Manoj
linked information resource: Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony.

Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony.
PubMed Identifier: 28211852
author list: Ganter M, Goldberg JM, Dvorin JD, Paulo JA, King JG, Tripathi AK, Paul AS, Yang J, Coppens I, Jiang RH, Elsworth B, Baker DA, Dinglasan RR, Gygi SP, Duraisingh MT
published in: Nature microbiology
information resource reference: Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony. Nat Microbiol. 2017 Feb 17; 2:17017.
journal title abbreviation: Nat Microbiol
publication date: 2017-02-17T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Erratum: Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony.
PubMed Identifier: 28263306
author list: Ganter M, Goldberg JM, Dvorin JD, Paulo JA, King JG, Tripathi AK, Paul AS, Yang J, Coppens I, Jiang RH, Elsworth B, Baker DA, Dinglasan RR, Gygi SP, Duraisingh MT
published in: Nature microbiology
information resource reference: Erratum: Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony. Nat Microbiol. 2017 Mar 06; 2:17038.
journal title abbreviation: Nat Microbiol
publication date: 2017-03-06T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

A genetic screen for improved plasmid segregation reveals a role for Rep20 in the interaction of Plasmodium falciparum chromosomes.
PubMed Identifier: 11867551
author list: O'Donnell RA, Freitas-Junior LH, Preiser PR, Williamson DH, Duraisingh M, McElwain TF, Scherf A, Cowman AF, Crabb BS
published in: The EMBO journal
information resource reference: A genetic screen for improved plasmid segregation reveals a role for Rep20 in the interaction of Plasmodium falciparum chromosomes. EMBO J. 2002 Mar 01; 21(5):1231-9.
journal title abbreviation: EMBO J
publication date: 2002-03-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes.
PubMed Identifier: 20466936
author list: Dvorin JD, Martyn DC, Patel SD, Grimley JS, Collins CR, Hopp CS, Bright AT, Westenberger S, Winzeler E, Blackman MJ, Baker DA, Wandless TJ, Duraisingh MT
published in: Science (New York, N.Y.)
information resource reference: A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science. 2010 May 14; 328(5980):910-2.
journal title abbreviation: Science
publication date: 2010-05-14T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes.
PubMed Identifier: 12606570
author list: Duraisingh MT, Triglia T, Ralph SA, Rayner JC, Barnwell JW, McFadden GI, Cowman AF
published in: The EMBO journal
information resource reference: Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes. EMBO J. 2003 Mar 03; 22(5):1047-57.
journal title abbreviation: EMBO J
publication date: 2003-03-03T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Plasmodium falciparum: detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion.
PubMed Identifier: 9603482
author list: Duraisingh MT, Curtis J, Warhurst DC
published in: Experimental parasitology
information resource reference: Plasmodium falciparum: detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion. Exp Parasitol. 1998 May; 89(1):1-8.
journal title abbreviation: Exp Parasitol
publication date: 1998-05-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Multiple drug resistance genes in malaria -- from epistasis to epidemiology.
PubMed Identifier: 16091030
author list: Duraisingh MT, Refour P
published in: Molecular microbiology
information resource reference: Multiple drug resistance genes in malaria -- from epistasis to epidemiology. Mol Microbiol. 2005 Aug; 57(4):874-7.
journal title abbreviation: Mol Microbiol
publication date: 2005-08-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

A genome-wide map of diversity in Plasmodium falciparum.
PubMed Identifier: 17159979
author list: Volkman SK, Sabeti PC, DeCaprio D, Neafsey DE, Schaffner SF, Milner DA, Daily JP, Sarr O, Ndiaye D, Ndir O, Mboup S, Duraisingh MT, Lukens A, Derr A, Stange-Thomann N, Waggoner S, Onofrio R, Ziaugra L, Mauceli E, Gnerre S, Jaffe DB, Zainoun J, Wiegand RC, Birren BW, Hartl DL, Galagan JE, Lander ES, Wirth DF
published in: Nature genetics
information resource reference: A genome-wide map of diversity in Plasmodium falciparum. Nat Genet. 2007 Jan; 39(1):113-9.
journal title abbreviation: Nat Genet
publication date: 2006-12-10T00:00:00
year: 2006
type: Academic Article
type: Article
type: Document
type: Information Resource

Analysis of pfcrt, pfmdr1, dhfr, and dhps mutations and drug sensitivities in Plasmodium falciparum isolates from patients in Vietnam before and after treatment with artemisinin.
PubMed Identifier: 12685644
author list: Ngo T, Duraisingh M, Reed M, Hipgrave D, Biggs B, Cowman AF
published in: The American journal of tropical medicine and hygiene
information resource reference: Analysis of pfcrt, pfmdr1, dhfr, and dhps mutations and drug sensitivities in Plasmodium falciparum isolates from patients in Vietnam before and after treatment with artemisinin. Am J Trop Med Hyg. 2003 Mar; 68(3):350-6.
journal title abbreviation: Am J Trop Med Hyg
publication date: 2003-03-01T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

An old enemy, a new battle plan. Perspective on combating drug-resistant malaria.
PubMed Identifier: 11258713
author list: Cowman AF, Duraisingh MT
published in: EMBO reports
information resource reference: An old enemy, a new battle plan. Perspective on combating drug-resistant malaria. EMBO Rep. 2001 Feb; 2(2):77-9.
journal title abbreviation: EMBO Rep
publication date: 2001-02-01T00:00:00
year: 2001
type: Academic Article
type: Article
type: Document
type: Information Resource

Functional analysis of epigenetic regulation of tandem RhopH1/clag genes reveals a role in Plasmodium falciparum growth.
PubMed Identifier: 21320181
author list: Comeaux CA, Coleman BI, Bei AK, Whitehurst N, Duraisingh MT
published in: Molecular microbiology
information resource reference: Functional analysis of epigenetic regulation of tandem RhopH1/clag genes reveals a role in Plasmodium falciparum growth. Mol Microbiol. 2011 Apr; 80(2):378-90.
journal title abbreviation: Mol Microbiol
publication date: 2011-03-07T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum.
PubMed Identifier: 22080952
author list: Crosnier C, Bustamante LY, Bartholdson SJ, Bei AK, Theron M, Uchikawa M, Mboup S, Ndir O, Kwiatkowski DP, Duraisingh MT, Rayner JC, Wright GJ
published in: Nature
information resource reference: Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum. Nature. 2011 Nov 09; 480(7378):534-7.
journal title abbreviation: Nature
publication date: 2011-11-09T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

A novel erythrocyte binding antigen-175 paralogue from Plasmodium falciparum defines a new trypsin-resistant receptor on human erythrocytes.
PubMed Identifier: 12556470
author list: Gilberger TW, Thompson JK, Triglia T, Good RT, Duraisingh MT, Cowman AF
published in: The Journal of biological chemistry
information resource reference: A novel erythrocyte binding antigen-175 paralogue from Plasmodium falciparum defines a new trypsin-resistant receptor on human erythrocytes. J Biol Chem. 2003 Apr 18; 278(16):14480-6.
journal title abbreviation: J Biol Chem
publication date: 2003-01-29T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Polymorphism of the Pfmdr1 gene and chloroquine resistance in Plasmodium falciparum in The Gambia.
PubMed Identifier: 9373652
author list: von Seidlein L, Duraisingh MT, Drakeley CJ, Bailey R, Greenwood BM, Pinder M
published in: Transactions of the Royal Society of Tropical Medicine and Hygiene
information resource reference: Polymorphism of the Pfmdr1 gene and chloroquine resistance in Plasmodium falciparum in The Gambia. Trans R Soc Trop Med Hyg. 1997 Jul-Aug; 91(4):450-3.
journal title abbreviation: Trans R Soc Trop Med Hyg
publication date: 1997-07-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Gambian children successfully treated with chloroquine can harbor and transmit Plasmodium falciparum gametocytes carrying resistance genes.
PubMed Identifier: 12518847
author list: Sutherland CJ, Alloueche A, Curtis J, Drakeley CJ, Ord R, Duraisingh M, Greenwood BM, Pinder M, Warhurst D, Targett GA
published in: The American journal of tropical medicine and hygiene
information resource reference: Gambian children successfully treated with chloroquine can harbor and transmit Plasmodium falciparum gametocytes carrying resistance genes. Am J Trop Med Hyg. 2002 Dec; 67(6):578-85.
journal title abbreviation: Am J Trop Med Hyg
publication date: 2002-12-01T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Contribution of the pfmdr1 gene to antimalarial drug-resistance.
PubMed Identifier: 15876420
author list: Duraisingh MT, Cowman AF
published in: Acta tropica
information resource reference: Contribution of the pfmdr1 gene to antimalarial drug-resistance. Acta Trop. 2005 Jun; 94(3):181-90.
journal title abbreviation: Acta Trop
publication date: 2005-06-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations.
PubMed Identifier: 12469115
author list: Maier AG, Duraisingh MT, Reeder JC, Patel SS, Kazura JW, Zimmerman PA, Cowman AF
published in: Nature medicine
information resource reference: Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations. Nat Med. 2003 Jan; 9(1):87-92.
journal title abbreviation: Nat Med
publication date: 2002-12-09T00:00:00
year: 2002
type: Academic Article
type: Article
type: Document
type: Information Resource

Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum.
PubMed Identifier: 19402747
author list: Tonkin CJ, Carret CK, Duraisingh MT, Voss TS, Ralph SA, Hommel M, Duffy MF, Silva LM, Scherf A, Ivens A, Speed TP, Beeson JG, Cowman AF
published in: PLoS biology
information resource reference: Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol. 2009 Apr 14; 7(4):e84.
journal title abbreviation: PLoS Biol
publication date: 2009-04-14T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Erythrocyte-binding antigen 175 mediates invasion in Plasmodium falciparum utilizing sialic acid-dependent and -independent pathways.
PubMed Identifier: 12672957
author list: Duraisingh MT, Maier AG, Triglia T, Cowman AF
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: Erythrocyte-binding antigen 175 mediates invasion in Plasmodium falciparum utilizing sialic acid-dependent and -independent pathways. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4796-801.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2003-04-02T00:00:00
year: 2003
type: Academic Article
type: Article
type: Document
type: Information Resource

Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum.
PubMed Identifier: 15820675
author list: Duraisingh MT, Voss TS, Marty AJ, Duffy MF, Good RT, Thompson JK, Freitas-Junior LH, Scherf A, Crabb BS, Cowman AF
published in: Cell
information resource reference: Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum. Cell. 2005 Apr 08; 121(1):13-24.
journal title abbreviation: Cell
publication date: 2005-04-08T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment.
PubMed Identifier: 9593041
author list: Curtis J, Duraisingh MT, Warhurst DC
published in: The Journal of infectious diseases
information resource reference: In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment. J Infect Dis. 1998 May; 177(5):1429-33.
journal title abbreviation: J Infect Dis
publication date: 1998-05-01T00:00:00
year: 1998
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 989228
type: Authorship
author rank in publication: 11
linked author: Duraisingh, Manoj
linked information resource: Functional Analysis Reveals Geographical Variation in Inhibitory Immune Responses Against a Polymorphic Malaria Antigen.

Functional Analysis Reveals Geographical Variation in Inhibitory Immune Responses Against a Polymorphic Malaria Antigen.
PubMed Identifier: 28605544
author list: Bei AK, Ahouidi AD, Dvorin JD, Miura K, Diouf A, Ndiaye D, Premji Z, Diakite M, Mboup S, Long CA, Duraisingh MT
published in: The Journal of infectious diseases
information resource reference: Functional Analysis Reveals Geographical Variation in Inhibitory Immune Responses Against a Polymorphic Malaria Antigen. J Infect Dis. 2017 07 15; 216(2):267-275.
journal title abbreviation: J Infect Dis
publication date: 2017-07-15T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Evolution of apicomplexan secretory organelles.
PubMed Identifier: 23068912
author list: Gubbels MJ, Duraisingh MT
published in: International journal for parasitology
information resource reference: Evolution of apicomplexan secretory organelles. Int J Parasitol. 2012 Nov; 42(12):1071-81.
journal title abbreviation: Int J Parasitol
publication date: 2012-10-13T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.
PubMed Identifier: 19317450
author list: Patel V, Mazitschek R, Coleman B, Nguyen C, Urgaonkar S, Cortese J, Barker RH, Greenberg E, Tang W, Bradner JE, Schreiber SL, Duraisingh MT, Wirth DF, Clardy J
published in: Journal of medicinal chemistry
information resource reference: Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. J Med Chem. 2009 Apr 23; 52(8):2185-7.
journal title abbreviation: J Med Chem
publication date: 2009-04-23T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Paul, Aditya
eCommons Login: ASP21
first name: Aditya
last name: Paul
full name: Aditya Shankar Paul, Ph.D.
has faculty rank: Other Faculty
Person ID: 22085
person in primary position: Research Scientist
type: Agent
type: Person
preferred title: Research Scientist

Authorship 994403
type: Authorship
author rank in publication: 9
linked author: Duraisingh, Manoj
linked information resource: PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum.

PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum.
PubMed Identifier: 28680058
author list: Kumar S, Kumar M, Ekka R, Dvorin JD, Paul AS, Madugundu AK, Gilberger T, Gowda H, Duraisingh MT, Keshava Prasad TS, Sharma P
published in: Nature communications
information resource reference: PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum. Nat Commun. 2017 07 05; 8(1):63.
journal title abbreviation: Nat Commun
publication date: 2017-07-05T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes by Plasmodium falciparum.
PubMed Identifier: 15612925
author list: Triglia T, Duraisingh MT, Good RT, Cowman AF
published in: Molecular microbiology
information resource reference: Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes by Plasmodium falciparum. Mol Microbiol. 2005 Jan; 55(1):162-74.
journal title abbreviation: Mol Microbiol
publication date: 2005-01-01T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Antisense RNA and RNAi in protozoan parasites: working hard or hardly working?
PubMed Identifier: 18053590
author list: Militello KT, Refour P, Comeaux CA, Duraisingh MT
published in: Molecular and biochemical parasitology
information resource reference: Antisense RNA and RNAi in protozoan parasites: working hard or hardly working? Mol Biochem Parasitol. 2008 Feb; 157(2):117-26.
journal title abbreviation: Mol Biochem Parasitol
publication date: 2007-10-18T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Geographical distribution of a variant epitope of Pfs48/45, a Plasmodium falciparum transmission-blocking vaccine candidate.
PubMed Identifier: 8898341
author list: Drakeley CJ, Duraisingh MT, Póvoa M, Conway DJ, Targett GA, Baker DA
published in: Molecular and biochemical parasitology
information resource reference: Geographical distribution of a variant epitope of Pfs48/45, a Plasmodium falciparum transmission-blocking vaccine candidate. Mol Biochem Parasitol. 1996 Oct 30; 81(2):253-7.
journal title abbreviation: Mol Biochem Parasitol
publication date: 1996-10-30T00:00:00
year: 1996
type: Academic Article
type: Article
type: Document
type: Information Resource

A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis.
PubMed Identifier: 22246776
author list: Farrell A, Thirugnanam S, Lorestani A, Dvorin JD, Eidell KP, Ferguson DJ, Anderson-White BR, Duraisingh MT, Marth GT, Gubbels MJ
published in: Science (New York, N.Y.)
information resource reference: A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis. Science. 2012 Jan 13; 335(6065):218-21.
journal title abbreviation: Science
publication date: 2012-01-13T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.
PubMed Identifier: 22195562
author list: Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH, Dvorin JD, Duraisingh MT, Wirth DF, Clardy J, Mazitschek R
published in: Chemistry & biology
information resource reference: Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chem Biol. 2011 Dec 23; 18(12):1602-10.
journal title abbreviation: Chem Biol
publication date: 2011-12-23T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1004681
type: Authorship
author rank in publication: 4
linked author: Duraisingh, Manoj
linked information resource: The Molecular Basis of Erythrocyte Invasion by Malaria Parasites.

The Molecular Basis of Erythrocyte Invasion by Malaria Parasites.
PubMed Identifier: 28799908
author list: Cowman AF, Tonkin CJ, Tham WH, Duraisingh MT
published in: Cell host & microbe
information resource reference: The Molecular Basis of Erythrocyte Invasion by Malaria Parasites. Cell Host Microbe. 2017 Aug 09; 22(2):232-245.
journal title abbreviation: Cell Host Microbe
publication date: 2017-08-09T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model.
PubMed Identifier: 20702404
author list: Booker ML, Bastos CM, Kramer ML, Barker RH, Skerlj R, Sidhu AB, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Crespo Llado KN, Serrano AE, Angulo-Barturen I, Jiménez-Díaz MB, Viera S, Garuti H, Wittlin S, Papastogiannidis P, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman B, Goldsmith EJ, Phillips MA, Munoz B, Wirth DF, Klinger JD, Wiegand R, Sybertz E
published in: The Journal of biological chemistry
information resource reference: Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. J Biol Chem. 2010 Oct 22; 285(43):33054-33064.
journal title abbreviation: J Biol Chem
publication date: 2010-08-11T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Functional analysis of red blood cell determinants of Plasmodium invasion
end date: 2021-01-31
principal investigator name: DURAISINGH, MANOJ T
start date: 2017-04-20
type: Grant
sponsor award id: R01HL139337

Principal Investigator
type: Researcher Role
researcher role of: Duraisingh, Manoj
contributes to: Functional analysis of red blood cell determinants of Plasmodium invasion

Authorship 1008333
type: Authorship
author rank in publication: 15
linked author: Duraisingh, Manoj
linked information resource: Genetic Evidence for Erythrocyte Receptor Glycophorin B Expression Levels Defining a Dominant Plasmodium falciparum Invasion Pathway into Human Erythrocytes.

Genetic Evidence for Erythrocyte Receptor Glycophorin B Expression Levels Defining a Dominant Plasmodium falciparum Invasion Pathway into Human Erythrocytes.
PubMed Identifier: 28760933
author list: Dankwa S, Chaand M, Kanjee U, Jiang RHY, Nobre LV, Goldberg JM, Bei AK, Moechtar MA, Grüring C, Ahouidi AD, Ndiaye D, Dieye TN, Mboup S, Weekes MP, Duraisingh MT
published in: Infection and immunity
information resource reference: Genetic Evidence for Erythrocyte Receptor Glycophorin B Expression Levels Defining a Dominant Plasmodium falciparum Invasion Pathway into Human Erythrocytes. Infect Immun. 2017 10; 85(10).
journal title abbreviation: Infect Immun
publication date: 2017-09-20T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin.
PubMed Identifier: 10802315
author list: Duraisingh MT, Jones P, Sambou I, von Seidlein L, Pinder M, Warhurst DC
published in: Molecular and biochemical parasitology
information resource reference: The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin. Mol Biochem Parasitol. 2000 Apr 30; 108(1):13-23.
journal title abbreviation: Mol Biochem Parasitol
publication date: 2000-04-30T00:00:00
year: 2000
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes.
PubMed Identifier: 16123303
author list: Stubbs J, Simpson KM, Triglia T, Plouffe D, Tonkin CJ, Duraisingh MT, Maier AG, Winzeler EA, Cowman AF
published in: Science (New York, N.Y.)
information resource reference: Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science. 2005 Aug 26; 309(5739):1384-7.
journal title abbreviation: Science
publication date: 2005-08-26T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Plasmodium research in the postgenomic era.
PubMed Identifier: 16311071
author list: Duraisingh M, Ferdig MT, Stoeckert CJ, Volkman SK, McGovern VP
published in: Trends in parasitology
information resource reference: Plasmodium research in the postgenomic era. Trends Parasitol. 2006 Jan; 22(1):1-4.
journal title abbreviation: Trends Parasitol
publication date: 2005-11-28T00:00:00
year: 2005
type: Academic Article
type: Article
type: Document
type: Information Resource

Cooperativity between Plasmodium falciparum adhesive proteins for invasion into erythrocytes.
PubMed Identifier: 19400777
author list: DeSimone TM, Jennings CV, Bei AK, Comeaux C, Coleman BI, Refour P, Triglia T, Stubbs J, Cowman AF, Duraisingh MT
published in: Molecular microbiology
information resource reference: Cooperativity between Plasmodium falciparum adhesive proteins for invasion into erythrocytes. Mol Microbiol. 2009 May; 72(3):578-89.
journal title abbreviation: Mol Microbiol
publication date: 2009-05-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

In vitro genetic analysis of an erythrocyte determinant of malaria infection.
PubMed Identifier: 20958212
author list: Bei AK, Brugnara C, Duraisingh MT
published in: The Journal of infectious diseases
information resource reference: In vitro genetic analysis of an erythrocyte determinant of malaria infection. J Infect Dis. 2010 Dec 01; 202(11):1722-7.
journal title abbreviation: J Infect Dis
publication date: 2010-10-19T00:00:00
year: 2010
type: Academic Article
type: Article
type: Document
type: Information Resource

Optimization of flow cytometric detection and cell sorting of transgenic Plasmodium parasites using interchangeable optical filters.
PubMed Identifier: 22950515
author list: Vorobjev IA, Buchholz K, Prabhat P, Ketman K, Egan ES, Marti M, Duraisingh MT, Barteneva NS
published in: Malaria journal
information resource reference: Optimization of flow cytometric detection and cell sorting of transgenic Plasmodium parasites using interchangeable optical filters. Malar J. 2012 Sep 05; 11:312.
journal title abbreviation: Malar J
publication date: 2012-09-05T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Erythrocyte invasion by Plasmodium falciparum: multiple ligand-receptor interactions and phenotypic switching.
PubMed Identifier: 18512340
author list: Duraisingh MT, DeSimone T, Jennings C, Refour P, Wu C
published in: Sub-cellular biochemistry
information resource reference: Erythrocyte invasion by Plasmodium falciparum: multiple ligand-receptor interactions and phenotypic switching. Subcell Biochem. 2008; 47:46-57.
journal title abbreviation: Subcell Biochem
publication date: 2008-01-01T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1022137
type: Authorship
author rank in publication: 11
linked author: Duraisingh, Manoj
linked information resource: CRISPR/Cas9 knockouts reveal genetic interaction between strain-transcendent erythrocyte determinants of Plasmodium falciparum invasion.

CRISPR/Cas9 knockouts reveal genetic interaction between strain-transcendent erythrocyte determinants of Plasmodium falciparum invasion.
PubMed Identifier: 29078358
author list: Kanjee U, Grüring C, Chaand M, Lin KM, Egan E, Manzo J, Jones PL, Yu T, Barker R, Weekes MP, Duraisingh MT
published in: Proceedings of the National Academy of Sciences of the United States of America
information resource reference: CRISPR/Cas9 knockouts reveal genetic interaction between strain-transcendent erythrocyte determinants of Plasmodium falciparum invasion. Proc Natl Acad Sci U S A. 2017 10 31; 114(44):E9356-E9365.
journal title abbreviation: Proc Natl Acad Sci U S A
publication date: 2017-10-19T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Transcriptional control and gene silencing in Plasmodium falciparum.
PubMed Identifier: 18637022
author list: Coleman BI, Duraisingh MT
published in: Cellular microbiology
information resource reference: Transcriptional control and gene silencing in Plasmodium falciparum. Cell Microbiol. 2008 Oct; 10(10):1935-46.
journal title abbreviation: Cell Microbiol
publication date: 2008-07-10T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.
PubMed Identifier: 21422215
author list: Barker RH, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman BI, Angulo-Barturen I, Jiménez-Díaz MB, Magán N, Gomez V, Ferrer S, Martínez MS, Wittlin S, Papastogiannidis P, O'Shea T, Klinger JD, Bree M, Lee E, Levine M, Wiegand RC, Munoz B, Wirth DF, Clardy J, Bathurst I, Sybertz E
published in: Antimicrobial agents and chemotherapy
information resource reference: Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum. Antimicrob Agents Chemother. 2011 Jun; 55(6):2612-22.
journal title abbreviation: Antimicrob Agents Chemother
publication date: 2011-03-21T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1022913
type: Authorship
author rank in publication: 3
linked author: Duraisingh, Manoj
linked information resource: Molecular interactions governing host-specificity of blood stage malaria parasites.

Molecular interactions governing host-specificity of blood stage malaria parasites.
PubMed Identifier: 29096194
author list: Scully EJ, Kanjee U, Duraisingh MT
published in: Current opinion in microbiology
information resource reference: Molecular interactions governing host-specificity of blood stage malaria parasites. Curr Opin Microbiol. 2017 Dec; 40:21-31.
journal title abbreviation: Curr Opin Microbiol
publication date: 2017-10-31T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Variant merozoite protein expression is associated with erythrocyte invasion phenotypes in Plasmodium falciparum isolates from Tanzania.
PubMed Identifier: 17303262
author list: Bei AK, Membi CD, Rayner JC, Mubi M, Ngasala B, Sultan AA, Premji Z, Duraisingh MT
published in: Molecular and biochemical parasitology
information resource reference: Variant merozoite protein expression is associated with erythrocyte invasion phenotypes in Plasmodium falciparum isolates from Tanzania. Mol Biochem Parasitol. 2007 May; 153(1):66-71.
journal title abbreviation: Mol Biochem Parasitol
publication date: 2007-01-16T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1026416
type: Authorship
author rank in publication: 22
linked author: Duraisingh, Manoj
linked information resource: Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum.

Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum.
PubMed Identifier: 29129376
author list: Brancucci NMB, Gerdt JP, Wang C, De Niz M, Philip N, Adapa SR, Zhang M, Hitz E, Niederwieser I, Boltryk SD, Laffitte MC, Clark MA, Grüring C, Ravel D, Blancke Soares A, Demas A, Bopp S, Rubio-Ruiz B, Conejo-Garcia A, Wirth DF, Gendaszewska-Darmach E, Duraisingh MT, Adams JH, Voss TS, Waters AP, Jiang RHY, Clardy J, Marti M
published in: Cell
information resource reference: Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum. Cell. 2017 Dec 14; 171(7):1532-1544.e15.
journal title abbreviation: Cell
publication date: 2017-11-09T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs.
PubMed Identifier: 21689454
author list: Broadbent KM, Park D, Wolf AR, Van Tyne D, Sims JS, Ribacke U, Volkman S, Duraisingh M, Wirth D, Sabeti PC, Rinn JL
published in: Genome biology
information resource reference: A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. Genome Biol. 2011 Jun 20; 12(6):R56.
journal title abbreviation: Genome Biol
publication date: 2011-06-20T00:00:00
year: 2011
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1029759
type: Authorship
author rank in publication: 4
linked author: Duraisingh, Manoj
linked information resource: Malaria in India: The Need for New Targets for Diagnosis and Detection of Plasmodium vivax.

Malaria in India: The Need for New Targets for Diagnosis and Detection of Plasmodium vivax.
PubMed Identifier: 29193853
author list: Patankar S, Sharma S, Rathod PK, Duraisingh MT
published in: Proteomics. Clinical applications
information resource reference: Malaria in India: The Need for New Targets for Diagnosis and Detection of Plasmodium vivax. Proteomics Clin Appl. 2018 07; 12(4):e1700024.
journal title abbreviation: Proteomics Clin Appl
publication date: 2018-01-11T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene.
PubMed Identifier: 23245319
author list: Coleman BI, Ribacke U, Manary M, Bei AK, Winzeler EA, Wirth DF, Duraisingh MT
published in: Cell host & microbe
information resource reference: Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene. Cell Host Microbe. 2012 Dec 13; 12(6):739-50.
journal title abbreviation: Cell Host Microbe
publication date: 2012-12-13T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Sickle cell microRNAs inhibit the malaria parasite.
PubMed Identifier: 22901533
author list: Duraisingh MT, Lodish HF
published in: Cell host & microbe
information resource reference: Sickle cell microRNAs inhibit the malaria parasite. Cell Host Microbe. 2012 Aug 16; 12(2):127-8.
journal title abbreviation: Cell Host Microbe
publication date: 2012-08-16T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1031667
type: Authorship
author rank in publication: 2
linked author: Duraisingh, Manoj
linked information resource: Targeting Plasmodium Proteases to Block Malaria Parasite Escape and Entry.

Targeting Plasmodium Proteases to Block Malaria Parasite Escape and Entry.
PubMed Identifier: 29269028
author list: Paul AS, Duraisingh MT
published in: Trends in parasitology
information resource reference: Targeting Plasmodium Proteases to Block Malaria Parasite Escape and Entry. Trends Parasitol. 2018 02; 34(2):95-97.
journal title abbreviation: Trends Parasitol
publication date: 2017-12-18T00:00:00
year: 2017
type: Academic Article
type: Article
type: Document
type: Information Resource

Erythrocyte invasion profiles are associated with a common invasion ligand polymorphism in Senegalese isolates of Plasmodium falciparum.
PubMed Identifier: 19126266
author list: Lantos PM, Ahouidi AD, Bei AK, Jennings CV, Sarr O, Ndir O, Wirth DF, Mboup S, Duraisingh MT
published in: Parasitology
information resource reference: Erythrocyte invasion profiles are associated with a common invasion ligand polymorphism in Senegalese isolates of Plasmodium falciparum. Parasitology. 2009 Jan; 136(1):1-9.
journal title abbreviation: Parasitology
publication date: 2009-01-01T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1036480
type: Authorship
author rank in publication: 23
linked author: Duraisingh, Manoj
linked information resource: Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax.

Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax.
PubMed Identifier: 29302006
author list: Gruszczyk J, Kanjee U, Chan LJ, Menant S, Malleret B, Lim NTY, Schmidt CQ, Mok YF, Lin KM, Pearson RD, Rangel G, Smith BJ, Call MJ, Weekes MP, Griffin MDW, Murphy JM, Abraham J, Sriprawat K, Menezes MJ, Ferreira MU, Russell B, Renia L, Duraisingh MT, Tham WH
published in: Science (New York, N.Y.)
information resource reference: Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Science. 2018 01 05; 359(6371):48-55.
journal title abbreviation: Science
publication date: 2018-01-05T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii.
PubMed Identifier: 19783771
author list: Bushkin GG, Ratner DM, Cui J, Banerjee S, Duraisingh MT, Jennings CV, Dvorin JD, Gubbels MJ, Robertson SD, Steffen M, O'Keefe BR, Robbins PW, Samuelson J
published in: Eukaryotic cell
information resource reference: Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii. Eukaryot Cell. 2010 Feb; 9(2):228-41.
journal title abbreviation: Eukaryot Cell
publication date: 2009-09-25T00:00:00
year: 2009
type: Academic Article
type: Article
type: Document
type: Information Resource

Molecular analysis of erythrocyte invasion in Plasmodium falciparum isolates from Senegal.
PubMed Identifier: 17470537
author list: Jennings CV, Ahouidi AD, Zilversmit M, Bei AK, Rayner J, Sarr O, Ndir O, Wirth DF, Mboup S, Duraisingh MT
published in: Infection and immunity
information resource reference: Molecular analysis of erythrocyte invasion in Plasmodium falciparum isolates from Senegal. Infect Immun. 2007 Jul; 75(7):3531-8.
journal title abbreviation: Infect Immun
publication date: 2007-04-30T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Mechanisms of gene regulation in Plasmodium.
PubMed Identifier: 17690387
author list: Deitsch K, Duraisingh M, Dzikowski R, Gunasekera A, Khan S, Le Roch K, Llinás M, Mair G, McGovern V, Roos D, Shock J, Sims J, Wiegand R, Winzeler E
published in: The American journal of tropical medicine and hygiene
information resource reference: Mechanisms of gene regulation in Plasmodium. Am J Trop Med Hyg. 2007 Aug; 77(2):201-8.
journal title abbreviation: Am J Trop Med Hyg
publication date: 2007-08-01T00:00:00
year: 2007
type: Academic Article
type: Article
type: Document
type: Information Resource

Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.
PubMed Identifier: 18842591
author list: Patel V, Booker M, Kramer M, Ross L, Celatka CA, Kennedy LM, Dvorin JD, Duraisingh MT, Sliz P, Wirth DF, Clardy J
published in: The Journal of biological chemistry
information resource reference: Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem. 2008 Dec 12; 283(50):35078-85.
journal title abbreviation: J Biol Chem
publication date: 2008-10-08T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors.
PubMed Identifier: 19097788
author list: Dong CK, Patel V, Yang JC, Dvorin JD, Duraisingh MT, Clardy J, Wirth DF
published in: Bioorganic & medicinal chemistry letters
information resource reference: Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorg Med Chem Lett. 2009 Feb 01; 19(3):972-5.
journal title abbreviation: Bioorg Med Chem Lett
publication date: 2008-11-24T00:00:00
year: 2008
type: Academic Article
type: Article
type: Document
type: Information Resource

Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans.
PubMed Identifier: 23535659
author list: Lim C, Hansen E, DeSimone TM, Moreno Y, Junker K, Bei A, Brugnara C, Buckee CO, Duraisingh MT
published in: Nature communications
information resource reference: Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans. Nat Commun. 2013; 4:1638.
journal title abbreviation: Nat Commun
publication date: 2013-01-01T00:00:00
year: 2013
type: Academic Article
type: Article
type: Document
type: Information Resource

Authorship 1043344
type: Authorship
author rank in publication: 12
linked author: Duraisingh, Manoj
linked information resource: Enhanced Ex Vivo Plasmodium vivax Intraerythrocytic Enrichment and Maturation for Rapid and Sensitive Parasite Growth Assays.

Enhanced Ex Vivo Plasmodium vivax Intraerythrocytic Enrichment and Maturation for Rapid and Sensitive Parasite Growth Assays.
PubMed Identifier: 29378713
author list: Rangel GW, Clark MA, Kanjee U, Lim C, Shaw-Saliba K, Menezes MJ, Mascarenhas A, Chery L, Gomes E, Rathod PK, Ferreira MU, Duraisingh MT
published in: Antimicrobial agents and chemotherapy
information resource reference: Enhanced Ex Vivo Plasmodium vivax Intraerythrocytic Enrichment and Maturation for Rapid and Sensitive Parasite Growth Assays. Antimicrob Agents Chemother. 2018 04; 62(4).
journal title abbreviation: Antimicrob Agents Chemother
publication date: 2018-03-27T00:00:00
year: 2018
type: Academic Article
type: Article
type: Document
type: Information Resource

Plasmodium falciparum: selection of serine 108 of dihydrofolate reductase during treatment of uncomplicated malaria with co-trimoxazole in Ugandan children.
PubMed Identifier: 10432069
author list: Jelinek T, Kilian AH, Curtis J, Duraisingh MT, Kabagambe G, von Sonnenburg F, Warhurst DC
published in: The American journal of tropical medicine and hygiene
information resource reference: Plasmodium falciparum: selection of serine 108 of dihydrofolate reductase during treatment of uncomplicated malaria with co-trimoxazole in Ugandan children. Am J Trop Med Hyg. 1999 Jul; 61(1):125-30.
journal title abbreviation: Am J Trop Med Hyg
publication date: 1999-07-01T00:00:00
year: 1999
type: Academic Article
type: Article
type: Document
type: Information Resource

Malaria evolution in South Asia: knowledge for control and elimination.
PubMed Identifier: 22266213
author list: Narayanasamy K, Chery L, Basu A, Duraisingh MT, Escalante A, Fowble J, Guler JL, Herricks T, Kumar A, Majumder P, Maki J, Mascarenhas A, Rodrigues J, Roy B, Sen S, Shastri J, Smith J, Valecha N, White J, Rathod PK
published in: Acta tropica
information resource reference: Malaria evolution in South Asia: knowledge for control and elimination. Acta Trop. 2012 Mar; 121(3):256-66.
journal title abbreviation: Acta Trop
publication date: 2012-01-14T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Epigenetic dysregulation of virulence gene expression in severe Plasmodium falciparum malaria.
PubMed Identifier: 22448008
author list: Merrick CJ, Huttenhower C, Buckee C, Amambua-Ngwa A, Gomez-Escobar N, Walther M, Conway DJ, Duraisingh MT
published in: The Journal of infectious diseases
information resource reference: Epigenetic dysregulation of virulence gene expression in severe Plasmodium falciparum malaria. J Infect Dis. 2012 May 15; 205(10):1593-600.
journal title abbreviation: J Infect Dis
publication date: 2012-03-23T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

Functional analysis of erythrocyte determinants of Plasmodium infection.
PubMed Identifier: 22726752
author list: Bei AK, Duraisingh MT
published in: International journal for parasitology
information resource reference: Functional analysis of erythrocyte determinants of Plasmodium infection. Int J Parasitol. 2012 May 15; 42(6):575-82.
journal title abbreviation: Int J Parasitol
publication date: 2012-04-19T00:00:00
year: 2012
type: Academic Article
type: Article
type: Document
type: Information Resource

High prevalence of mutations in the dihydrofolate reductase gene of Plasmodium falciparum in isolates from Tanzania without evidence of an association to clinical sulfadoxine/pyrimethamine resistance.
PubMed Identifier: 9391510
author list: Jelinek T, Rønn AM, Curtis J, Duraisingh MT, Lemnge MM, Mhina J, Bygbjerg IC, Warhurst DC
published in: Tropical medicine & international health : TM & IH
information resource reference: High prevalence of mutations in the dihydrofolate reductase gene of Plasmodium falciparum in isolates from Tanzania without evidence of an association to clinical sulfadoxine/pyrimethamine resistance. Trop Med Int Health. 1997 Nov; 2(11):1075-9.
journal title abbreviation: Trop Med Int Health
publication date: 1997-11-01T00:00:00
year: 1997
type: Academic Article
type: Article
type: Document
type: Information Resource

Functional analysis of epigenetic regulators of malaria blood-stage proliferation and transmission
end date: 2023-04-30
principal investigator name: DURAISINGH, MANOJ T
start date: 2018-02-20
type: Grant
sponsor award id: R01AI138551

Principal Investigator
type: Researcher Role
researcher role of: Duraisingh, Manoj
contributes to: Functional analysis of epigenetic regulators of malaria blood-stage proliferation and transmission