Malaria remains one of the most serious infectious diseases of humans with an estimated 500 million new infections and approximately 2 million deaths each year. We are interested in understanding the processes that underlie the pathogenesis of human malarial disease at the cellular and molecular level. Plasmodium falciparum is a protozoan parasite, which multiplies exponentially in red blood cells (erythrocytes) in the course of its life-cycle, resulting in the clinical symptoms associated with severe malaria. We have developed transfection-based molecular and cell biological tools for the functional analysis of genes that may be involved in the initiation and progression of disease. We are also developing forward genetic screens for the identification of new molecules associated with virulence. These advances have coincided with the complete sequencing of the P. falciparum genome, which provides us with a blueprint to unravel the unique biology and genetics of this organism. In the laboratory, we focus on the molecular basis of erythrocyte invasion by P. falciparum. To initiate a blood-stage infection, invasive forms (known as merozoites) recognize multiple receptors on the surface of the erythrocyte, after which they signal to initiate a cascade of intracellular events to complete the invasion process. We are interested in elucidating the functions of the molecules involved in this complex process. Such an understanding is a prerequisite for the rational design of vaccines directed against this life-cycle stage. Also of interest is the regulation of antigenic variation in P. falciparum-infected erythrocytes. Following invasion, P. falciparum remodels the infected erythrocyte with the export of various proteins to the erythrocyte surface. Amongst these is a family of molecules, encoded by the var gene family, that are central both to the adherence of infected cells to specific human endothelial receptors and to the evasion of host immune responses raised against this adhesin. We are studying the mechanisms of gene silencing that lead to the mutually exclusive expression of a single member of the var gene family. This includes an understanding of the unique telomere biology of the parasite. We also have a long-standing interest in elucidating the molecular basis of P. falciparum drug-resistance. In the absence of an effective vaccine, chemotherapy is the mainstay of malaria treatment. This is becomingly increasingly compromised through the development and spread of antimalarial resistance. We are engaged in field projects with collaborators in malaria-endemic areas, including Senegal, Nigeria and Tanzania, to determine the relevance of our laboratory findings in different epidemiological settings.
John LaPorte Given Professor of Immunology and Infectious Diseases
Duraisingh MT, Roper C, Walliker D, Warhurst DC
Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum. Mol Microbiol. 2000 May; 36(4):955-61.
Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum.
Price RN, Cassar C, Brockman A, Duraisingh M, van Vugt M, White NJ, Nosten F, Krishna S
The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand. Antimicrob Agents Chemother. 1999 Dec; 43(12):2943-9.
The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand.
Sangster N, Batterham P, Chapman HD, Duraisingh M, Le Jambre L, Shirley M, Upcroft J, Upcroft P
Resistance to antiparasitic drugs: the role of molecular diagnosis. Int J Parasitol. 2002 May; 32(5):637-53.
Resistance to antiparasitic drugs: the role of molecular diagnosis.
Duraisingh MT, Drakeley CJ, Muller O, Bailey R, Snounou G, Targett GA, Greenwood BM, Warhurst DC
Evidence for selection for the tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum by chloroquine and amodiaquine. Parasitology. 1997 Mar; 114 ( Pt 3):205-11.
Evidence for selection for the tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum by chloroquine and amodiaquine.
Jelinek T, Rønn AM, Lemnge MM, Curtis J, Mhina J, Duraisingh MT, Bygbjerg IC, Warhurst DC
Tropical medicine & international health : TM & IH
Polymorphisms in the dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) genes of Plasmodium falciparum and in vivo resistance to sulphadoxine/pyrimethamine in isolates from Tanzania. Trop Med Int Health. 1998 Aug; 3(8):605-9.
Polymorphisms in the dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) genes of Plasmodium falciparum and in vivo resistance to sulphadoxine/pyrimethamine in isolates from Tanzania.
Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination. Int J Parasitol. 2002 Jan; 32(1):81-9.
Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination.
Merrick CJ, Dzikowski R, Imamura H, Chuang J, Deitsch K, Duraisingh MT
The effect of Plasmodium falciparum Sir2a histone deacetylase on clonal and longitudinal variation in expression of the var family of virulence genes. Int J Parasitol. 2010 Jan; 40(1):35-43.
The effect of Plasmodium falciparum Sir2a histone deacetylase on clonal and longitudinal variation in expression of the var family of virulence genes.
Bei AK, Desimone TM, Badiane AS, Ahouidi AD, Dieye T, Ndiaye D, Sarr O, Ndir O, Mboup S, Duraisingh MT
A flow cytometry-based assay for measuring invasion of red blood cells by Plasmodium falciparum. Am J Hematol. 2010 Apr; 85(4):234-7.
A flow cytometry-based assay for measuring invasion of red blood cells by Plasmodium falciparum.
Obaldia N, Meibalan E, Sa JM, Ma S, Clark MA, Mejia P, Moraes Barros RR, Otero W, Ferreira MU, Mitchell JR, Milner DA, Huttenhower C, Wirth DF, Duraisingh MT, Wellems TE, Marti M
Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection. mBio. 2018 05 08; 9(3).
Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection.
Baldi DL, Good R, Duraisingh MT, Crabb BS, Cowman AF
Identification and disruption of the gene encoding the third member of the low-molecular-mass rhoptry complex in Plasmodium falciparum. Infect Immun. 2002 Sep; 70(9):5236-45.
Identification and disruption of the gene encoding the third member of the low-molecular-mass rhoptry complex in Plasmodium falciparum.
Epigenetic Variation and Regulation in Malaria Parasites. Annu Rev Microbiol. 2018 Sep 08; 72:355-375.
Epigenetic Variation and Regulation in Malaria Parasites.
Archer NM, Petersen N, Clark MA, Buckee CO, Childs LM, Duraisingh MT
Proceedings of the National Academy of Sciences of the United States of America
Resistance to Plasmodium falciparum in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition. Proc Natl Acad Sci U S A. 2018 07 10; 115(28):7350-7355.
Resistance to Plasmodium falciparum in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition.
Zhou Y, Ramachandran V, Kumar KA, Westenberger S, Refour P, Zhou B, Li F, Young JA, Chen K, Plouffe D, Henson K, Nussenzweig V, Carlton J, Vinetz JM, Duraisingh MT, Winzeler EA
Evidence-based annotation of the malaria parasite's genome using comparative expression profiling. PLoS One. 2008 Feb 13; 3(2):e1570.
Evidence-based annotation of the malaria parasite's genome using comparative expression profiling.
Forward genetic overexpression screens to identify parasite determinants of antimalarial susceptibility
Elucidating ligand-receptor interactions required for Plasmodium vivax blood-stage infection
Heterochromatin-mediated control of virulence gene expression. Mol Microbiol. 2006 Nov; 62(3):612-20.
Heterochromatin-mediated control of virulence gene expression.
DeSimone TM, Bei AK, Jennings CV, Duraisingh MT
Genetic analysis of the cytoplasmic domain of the PfRh2b merozoite invasion protein of Plasmodium falciparum. Int J Parasitol. 2009 Mar; 39(4):399-405.
Genetic analysis of the cytoplasmic domain of the PfRh2b merozoite invasion protein of Plasmodium falciparum.
Unravelling a histone code for malaria virulence. Mol Microbiol. 2007 Dec; 66(6):1291-5.
Unravelling a histone code for malaria virulence.
Badiane AS, Sarr O, Deme AB, Ahouidi AD, Gueye PE, Ndiaye M, Seck MC, Diallo M, Bei AK, Duraisingh MT, Wirth D, Ndiaye D, Ndir O, Mboup S
Journal of infection in developing countries
Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal. J Infect Dev Ctries. 2012 Oct 19; 6(10):727-33.
Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal.
Dvorin JD, Bei AK, Coleman BI, Duraisingh MT
Functional diversification between two related Plasmodium falciparum merozoite invasion ligands is determined by changes in the cytoplasmic domain. Mol Microbiol. 2010 Feb; 75(4):990-1006.
Functional diversification between two related Plasmodium falciparum merozoite invasion ligands is determined by changes in the cytoplasmic domain.
Doumbia SO, Ndiaye D, Koita OA, Diakité M, Nwakanma D, Coulibaly M, Traoré SF, Keating J, Milner DA, Ndiaye JL, Sene PD, Ahouidi A, Dieye TN, Gaye O, Okebe J, Ceesay SJ, Ngwa A, Oriero EC, Konaté L, Sy N, Jawara M, Faye O, Kéita M, Cissé M, Sogoba N, Poudiougou B, Diawara S, Sangaré L, Coulibaly T, Seck I, Abubakar I, Gomis J, Mather FJ, Sissako A, Diarra A, Kandeh B, Whalen C, Moyer B, Nnedu O, Thiero O, Bei AK, Daniels R, Miura K, Long CA, Fairhurst RM, Duraisingh M, Muskavitch MA, D'Alessandro U, Conway DJ, Volkman SK, Valim C, Wirth DF, Krogstad DJ
Improving malaria control in West Africa: interruption of transmission as a paradigm shift. Acta Trop. 2012 Mar; 121(3):175-83.
Improving malaria control in West Africa: interruption of transmission as a paradigm shift.
Ceesay SJ, Bojang KA, Nwakanma D, Conway DJ, Koita OA, Doumbia SO, Ndiaye D, Coulibaly TF, Diakité M, Traoré SF, Coulibaly M, Ndiaye JL, Sarr O, Gaye O, Konaté L, Sy N, Faye B, Faye O, Sogoba N, Jawara M, Dao A, Poudiougou B, Diawara S, Okebe J, Sangaré L, Abubakar I, Sissako A, Diarra A, Kéita M, Kandeh B, Long CA, Fairhurst RM, Duraisingh M, Perry R, Muskavitch MA, Valim C, Volkman SK, Wirth DF, Krogstad DJ
Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes. Acta Trop. 2012 Mar; 121(3):166-74.
Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes.
Egan ES, Weekes MP, Kanjee U, Manzo J, Srinivasan A, Lomas-Francis C, Westhoff C, Takahashi J, Tanaka M, Watanabe S, Brugnara C, Gygi SP, Tani Y, Duraisingh MT
Erythrocytes lacking the Langereis blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparum. Commun Biol. 2018; 1:45.
Erythrocytes lacking the Langereis blood group protein ABCB6 are resistant to the malaria parasite Plasmodium falciparum.
Artavanis-Tsakonas K, Misaghi S, Comeaux CA, Catic A, Spooner E, Duraisingh MT, Ploegh HL
Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum. Mol Microbiol. 2006 Sep; 61(5):1187-95.
Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum.
Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity. Eukaryot Cell. 2007 Nov; 6(11):2081-91.
Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity.
Kanjee U, Rangel GW, Clark MA, Duraisingh MT
Molecular and cellular interactions defining the tropism of Plasmodium vivax for reticulocytes. Curr Opin Microbiol. 2018 12; 46:109-115.
Molecular and cellular interactions defining the tropism of Plasmodium vivax for reticulocytes.
To kill a piroplasm: genetic technologies to advance drug discovery and target identification in Babesia. Int J Parasitol. 2019 02; 49(2):153-163.
To kill a piroplasm: genetic technologies to advance drug discovery and target identification in Babesia.
Transactions of the Royal Society of Tropical Medicine and Hygiene
Rational use of drugs against Plasmodium falciparum. Trans R Soc Trop Med Hyg. 2001 Jul-Aug; 95(4):345-6.
Rational use of drugs against Plasmodium falciparum.
Cowman AF, Baldi DL, Duraisingh M, Healer J, Mills KE, O'Donnell RA, Thompson J, Triglia T, Wickham ME, Crabb BS
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development. Philos Trans R Soc Lond B Biol Sci. 2002 Jan 29; 357(1417):25-33.
Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development.
Ahouidi AD, Bei AK, Neafsey DE, Sarr O, Volkman S, Milner D, Cox-Singh J, Ferreira MU, Ndir O, Premji Z, Mboup S, Duraisingh MT
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens. Infect Genet Evol. 2010 Mar; 10(2):200-6.
Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens.
Epigenetics in Plasmodium: what do we really know? Eukaryot Cell. 2010 Aug; 9(8):1150-8.
Epigenetics in Plasmodium: what do we really know?
Wong W, Huang R, Menant S, Hong C, Sandow JJ, Birkinshaw RW, Healer J, Hodder AN, Kanjee U, Tonkin CJ, Heckmann D, Soroka V, Søgaard TMM, Jørgensen T, Duraisingh MT, Czabotar PE, de Jongh WA, Tham WH, Webb AI, Yu Z, Cowman AF
Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex. Nature. 2019 01; 565(7737):118-121.
Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex.
Duraisingh MT, Jones P, Sambou I, von Seidlein L, Pinder M, Warhurst DC
Inoculum effect leads to overestimation of in vitro resistance for artemisinin derivatives and standard antimalarials: a Gambian field study. Parasitology. 1999 Nov; 119 ( Pt 5):435-40.
Inoculum effect leads to overestimation of in vitro resistance for artemisinin derivatives and standard antimalarials: a Gambian field study.
Artavanis-Tsakonas K, Weihofen WA, Antos JM, Coleman BI, Comeaux CA, Duraisingh MT, Gaudet R, Ploegh HL
Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3. J Biol Chem. 2010 Feb 26; 285(9):6857-66.
Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3.
Elucidating Host Cell Uptake by Malaria Parasites. Trends Parasitol. 2019 05; 35(5):333-335.
Elucidating Host Cell Uptake by Malaria Parasites.
Harvard T.H. Chan School of Public Health
Richard Pearson Strong Professor of Infectious Diseases
Associate Professor of Immunology and Infectious Diseases
Scully EJ, Shabani E, Rangel GW, Grüring C, Kanjee U, Clark MA, Chaand M, Kurita R, Nakamura Y, Ferreira MU, Duraisingh MT
Generation of an immortalized erythroid progenitor cell line from peripheral blood: A model system for the functional analysis of Plasmodium spp. invasion. Am J Hematol. 2019 09; 94(9):963-974.
Generation of an immortalized erythroid progenitor cell line from peripheral blood: A model system for the functional analysis of Plasmodium spp. invasion.
Fetal hemoglobin does not inhibit Plasmodium falciparum growth. Blood Adv. 2019 07 23; 3(14):2149-2152.
Fetal hemoglobin does not inhibit Plasmodium falciparum growth.
Ravenhill BJ, Kanjee U, Ahouidi A, Nobre L, Williamson J, Goldberg JM, Antrobus R, Dieye T, Duraisingh MT, Weekes MP
Quantitative comparative analysis of human erythrocyte surface proteins between individuals from two genetically distinct populations. Commun Biol. 2019; 2:350.
Quantitative comparative analysis of human erythrocyte surface proteins between individuals from two genetically distinct populations.
Proto WR, Siegel SV, Dankwa S, Liu W, Kemp A, Marsden S, Zenonos ZA, Unwin S, Sharp PM, Wright GJ, Hahn BH, Duraisingh MT, Rayner JC
Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand. Nat Commun. 2019 10 04; 10(1):4512.
Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand.
Quantitative comparative analysis of human erythrocyte surface proteins between individuals from two genetically distinct populations. Commun Biol. 2019 Sep 20; 2(1):350.
Rangel GW, Clark MA, Kanjee U, Goldberg JM, MacInnis B, José Menezes M, Ferreira MU, Duraisingh MT
Plasmodium vivax transcriptional profiling of low input cryopreserved isolates through the intraerythrocytic development cycle. PLoS Negl Trop Dis. 2020 03; 14(3):e0008104.
Plasmodium vivax transcriptional profiling of low input cryopreserved isolates through the intraerythrocytic development cycle.
Cai FY, DeSimone TM, Hansen E, Jennings CV, Bei AK, Ahouidi AD, Mboup S, Duraisingh MT, Buckee CO
Accounting for red blood cell accessibility reveals distinct invasion strategies in Plasmodium falciparum strains. PLoS Comput Biol. 2020 04; 16(4):e1007702.
Accounting for red blood cell accessibility reveals distinct invasion strategies in Plasmodium falciparum strains.
Developing comparative chemical genomics and genetic validation tools for Babesia spp.
Gubbels MJ, Keroack CD, Dangoudoubiyam S, Worliczek HL, Paul AS, Bauwens C, Elsworth B, Engelberg K, Howe DK, Coppens I, Duraisingh MT
Frontiers in cellular and infection microbiology
Fussing About Fission: Defining Variety Among Mainstream and Exotic Apicomplexan Cell Division Modes. Front Cell Infect Microbiol. 2020; 10:269.
Fussing About Fission: Defining Variety Among Mainstream and Exotic Apicomplexan Cell Division Modes.
Hung J, Goodman A, Ravel D, Lopes SCP, Rangel GW, Nery OA, Malleret B, Nosten F, Lacerda MVG, Ferreira MU, Rénia L, Duraisingh MT, Costa FTM, Marti M, Carpenter AE
Keras R-CNN: library for cell detection in biological images using deep neural networks. BMC Bioinformatics. 2020 Jul 11; 21(1):300.
Keras R-CNN: library for cell detection in biological images using deep neural networks.
Paul AS, Miliu A, Paulo JA, Goldberg JM, Bonilla AM, Berry L, Seveno M, Braun-Breton C, Kosber AL, Elsworth B, Arriola JSN, Lebrun M, Gygi SP, Lamarque MH, Duraisingh MT
Co-option of Plasmodium falciparum PP1 for egress from host erythrocytes. Nat Commun. 2020 07 15; 11(1):3532.
Co-option of Plasmodium falciparum PP1 for egress from host erythrocytes.
London School of Hygiene and Tropical Medicine
London School of Hygiene and Tropical Medicine,
Kanjee U, Grüring C, Babar P, Meyers A, Dash R, Pereira L, Mascarenhas A, Chaand M, Rangel GW, Clark MA, Chery L, Gomes E, Rathod PK, Duraisingh MT
Plasmodium vivax Strains Use Alternative Pathways for Invasion. J Infect Dis. 2021 05 28; 223(10):1817-1821.
Plasmodium vivax Strains Use Alternative Pathways for Invasion.
Transformative tools for parasitic flatworms. Science. 2020 09 25; 369(6511):1562-1564.
Transformative tools for parasitic flatworms.
Linking nutrient sensing and gene expression in Plasmodium falciparum blood-stage parasites. Mol Microbiol. 2021 05; 115(5):891-900.
Linking nutrient sensing and gene expression in Plasmodium falciparum blood-stage parasites.
Three Signatures of Adaptive Polymorphism Exemplified by Malaria-Associated Genes. Mol Biol Evol. 2021 04 13; 38(4):1356-1371.
Three Signatures of Adaptive Polymorphism Exemplified by Malaria-Associated Genes.
A framework for signaling throughout the life cycle of Babesia species. Mol Microbiol. 2021 05; 115(5):882-890.
A framework for signaling throughout the life cycle of Babesia species.
Author Correction: Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand. Nat Commun. 2021 Feb 16; 12(1):1188.
Author Correction: Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand.
Clark MA, Kanjee U, Rangel GW, Chery L, Mascarenhas A, Gomes E, Rathod PK, Brugnara C, Ferreira MU, Duraisingh MT
Plasmodium vivax infection compromises reticulocyte stability. Nat Commun. 2021 03 12; 12(1):1629.
Plasmodium vivax infection compromises reticulocyte stability.
Gubbels MJ, Coppens I, Zarringhalam K, Duraisingh MT, Engelberg K
The Modular Circuitry of Apicomplexan Cell Division Plasticity. Front Cell Infect Microbiol. 2021; 11:670049.
The Modular Circuitry of Apicomplexan Cell Division Plasticity.
International journal for parasitology. Drugs and drug resistance
The molecular basis of antimalarial drug resistance in Plasmodium vivax. Int J Parasitol Drugs Drug Resist. 2021 08; 16:23-37.
The molecular basis of antimalarial drug resistance in Plasmodium vivax.
Deconstructing the parasite multiplication rate of Plasmodium falciparum. Trends Parasitol. 2021 10; 37(10):922-932.
Deconstructing the parasite multiplication rate of Plasmodium falciparum.
Olivieri A, Lee RS, Fratini F, Keutcha C, Chaand M, Mangano V, Celani F, Mochi S, Birago C, Paone S, Grasso F, Tirelli V, Falchi M, Shabani E, Bertoncini S, Sirima BS, Pizzi E, Modiano D, Duraisingh MT, Ponzi M
Structural organization of erythrocyte membrane microdomains and their relation with malaria susceptibility. Commun Biol. 2021 12 08; 4(1):1375.
Structural organization of erythrocyte membrane microdomains and their relation with malaria susceptibility.
Hung J, Lopes SCP, Nery OA, Nosten F, Ferreira MU, Duraisingh MT, Marti M, Ravel D, Rangel G, Malleret B, Lacerda MVG, Rénia L, Costa FTM, Carpenter AE
Conference on Computer Vision and Pattern Recognition Workshops. IEEE Computer Society Conference on Computer Vision and Pattern Recognition. Workshops
Applying Faster R-CNN for Object Detection on Malaria Images. Conf Comput Vis Pattern Recognit Workshops. 2017 Jul; 2017:808-813.
Conf Comput Vis Pattern Recognit Workshops
Applying Faster R-CNN for Object Detection on Malaria Images.
RBC membrane biomechanics and Plasmodium falciparum invasion: probing beyond ligand-receptor interactions. Trends Parasitol. 2022 04; 38(4):302-315.
RBC membrane biomechanics and Plasmodium falciparum invasion: probing beyond ligand-receptor interactions.
Vandorpe DH, Rivera A, Ganter M, Dankwa S, Wohlgemuth JG, Dlott JS, Snyder LM, Brugnara C, Duraisingh M, Alper SL
Pflugers Archiv : European journal of physiology
Purinergic signaling is essential for full Psickle activation by hypoxia and by normoxic acid pH in mature human sickle red cells and in vitro-differentiated cultured human sickle reticulocytes. Pflugers Arch. 2022 05; 474(5):553-565.
Purinergic signaling is essential for full Psickle activation by hypoxia and by normoxic acid pH in mature human sickle red cells and in vitro-differentiated cultured human sickle reticulocytes.
Kumar S, Li X, McDew-White M, Reyes A, Delgado E, Sayeed A, Haile MT, Abatiyow BA, Kennedy SY, Camargo N, Checkley LA, Brenneman KV, Button-Simons KA, Duraisingh MT, Cheeseman IH, Kappe SHI, Nosten F, Ferdig MT, Vaughan AM, Anderson TJC
A Malaria Parasite Cross Reveals Genetic Determinants of Plasmodium falciparum Growth in Different Culture Media. Front Cell Infect Microbiol. 2022; 12:878496.
A Malaria Parasite Cross Reveals Genetic Determinants of Plasmodium falciparum Growth in Different Culture Media.
Archer NM, Pasvol G, Wilson I, Duraisingh MT
Does fetal hemoglobin inhibit the malarial parasite Plasmodium falciparum? Am J Hematol. 2022 09; 97(9):E325-E327.
Does fetal hemoglobin inhibit the malarial parasite Plasmodium falciparum?
Molecular mechanisms of cellular quiescence in apicomplexan parasites. Curr Opin Microbiol. 2022 12; 70:102223.
Molecular mechanisms of cellular quiescence in apicomplexan parasites.
Mascarenhas A, Chakrabarti R, Chery-Karschney L, White J, Skillman KM, Kanjee U, Babar PH, Patrapuvich R, Mohanty AK, Duraisingh MT, Rathod PK
The American journal of tropical medicine and hygiene
International Center of Excellence for Malaria Research for South Asia and Broader Malaria Research in India. Am J Trop Med Hyg. 2022 10 11; 107(4_Suppl):118-123.
International Center of Excellence for Malaria Research for South Asia and Broader Malaria Research in India.
Scully EJ, Liu W, Li Y, Ndjango JN, Peeters M, Kamenya S, Pusey AE, Lonsdorf EV, Sanz CM, Morgan DB, Piel AK, Stewart FA, Gonder MK, Simmons N, Asiimwe C, Zuberbühler K, Koops K, Chapman CA, Chancellor R, Rundus A, Huffman MA, Wolfe ND, Duraisingh MT, Hahn BH, Wrangham RW
The ecology and epidemiology of malaria parasitism in wild chimpanzee reservoirs. Commun Biol. 2022 09 27; 5(1):1020.
The ecology and epidemiology of malaria parasitism in wild chimpanzee reservoirs.
Rezvani Y, Keroack CD, Elsworth B, Arriojas A, Gubbels MJ, Duraisingh MT, Zarringhalam K
Comparative single-cell transcriptional atlases of Babesia species reveal conserved and species-specific expression profiles. PLoS Biol. 2022 09; 20(9):e3001816.
Comparative single-cell transcriptional atlases of Babesia species reveal conserved and species-specific expression profiles.
Chakrabarti R, Chery-Karschney L, White J, Mascarenhas A, Skillman KM, Kanjee U, Babar PH, Patrapuvich R, Mohapatra PK, Patankar S, Smith JD, Anvikar A, Valecha N, Rahi M, Duraisingh MT, Rathod PK
Diverse Malaria Presentations across National Institutes of Health South Asia International Center for Excellence in Malaria Research Sites in India. Am J Trop Med Hyg. 2022 10 11; 107(4_Suppl):107-117.
Diverse Malaria Presentations across National Institutes of Health South Asia International Center for Excellence in Malaria Research Sites in India.
Duraisingh MT, Gubbels MJ, Zarringhalam K
A rising tide of parasite transcriptomics propels pathogen biology. PLoS Biol. 2023 01; 21(1):e3001997.
A rising tide of parasite transcriptomics propels pathogen biology.
Elsworth B, Keroack C, Rezvani Y, Paul A, Barazorda K, Tennessen J, Sack S, Moreira C, Gubbels MJ, Meyers M, Zarringhalam K, Duraisingh M
Babesia divergens egress from host cells is orchestrated by essential and druggable kinases and proteases. Res Sq. 2023 Feb 28.
Babesia divergens egress from host cells is orchestrated by essential and druggable kinases and proteases.
Keroack CD, Elsworth B, Tennessen JA, Paul AS, Hua R, Ramirez-Ramirez L, Ye S, Moreira CM, Meyers MJ, Zarringhalam K, Duraisingh MT
bioRxiv : the preprint server for biology
Comparative chemical genomics in Babesia species identifies the alkaline phosphatase phoD as a novel determinant of resistance. bioRxiv. 2023 Jun 13.
Comparative chemical genomics in Babesia species identifies the alkaline phosphatase phoD as a novel determinant of resistance.
Dash R, Skillman KM, Pereira L, Mascarenhas A, Dass S, Walke J, Almeida A, Fernandes M, Gomes E, White J, Chery-Karschney L, Khandeparkar A, Rathod PK, Duraisingh MT, Kanjee U
Development of a Plasmodium vivax biobank for functional ex vivo assays. bioRxiv. 2023 Mar 18.
Development of a Plasmodium vivax biobank for functional ex vivo assays.
Archer NM, Gnangnon B, Mikdar M, Ciuculescu MF, Petersen N, Staffa SJ, Duraisingh MT
F-erythrocytes promote Plasmodium falciparum proliferation in sickle cell disease. Am J Hematol. 2023 10; 98(10):1598-1605.
F-erythrocytes promote Plasmodium falciparum proliferation in sickle cell disease.
Kundu P, Naskar D, McKie SJ, Dass S, Kanjee U, Introini V, Ferreira MU, Cicuta P, Duraisingh M, Deane JE, Rayner JC
The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family. Nat Commun. 2023 09 14; 14(1):5703.
The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family.
Development of a Plasmodium vivax biobank for functional ex vivo assays. Malar J. 2023 Aug 31; 22(1):250.
Sekar P, Rajagopalan S, Shabani E, Kanjee U, Schureck MA, Arora G, Peterson ME, Traore B, Crompton PD, Duraisingh MT, Desai SA, Long EO
NK cell-induced damage to P.falciparum-infected erythrocytes requires ligand-specific recognition and releases parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG. PLoS Pathog. 2023 11; 19(11):e1011585.
NK cell-induced damage to P.falciparum-infected erythrocytes requires ligand-specific recognition and releases parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG.
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The Molecular Basis of Erythrocyte Invasion by Malaria Parasites. Cell Host Microbe. 2017 Aug 09; 22(2):232-245.
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A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs.
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Rangel GW, Clark MA, Kanjee U, Lim C, Shaw-Saliba K, Menezes MJ, Mascarenhas A, Chery L, Gomes E, Rathod PK, Ferreira MU, Duraisingh MT
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High prevalence of mutations in the dihydrofolate reductase gene of Plasmodium falciparum in isolates from Tanzania without evidence of an association to clinical sulfadoxine/pyrimethamine resistance.
Functional analysis of epigenetic regulators of malaria blood-stage proliferation and transmission