HL63HakhoLeeHakho Lee, Ph.D.42.37730000000000-71.0525000000000076631Lee, HakhoProfessor of Radiologycatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofvivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson23092113Agasti SS, Liong M, Peterson VM, Lee H, Weissleder RJournal of the American Chemical SocietyPhotocleavable DNA barcode-antibody conjugates allow sensitive and multiplexed protein analysis in single cells. J Am Chem Soc. 2012 Nov 14; 134(45):18499-502.J Am Chem Soc2012-11-02T00:00:002012Photocleavable DNA barcode-antibody conjugates allow sensitive and multiplexed protein analysis in single cells.22996932Agasti SS, Kohler RH, Liong M, Peterson VM, Lee H, Weissleder RSmall (Weinheim an der Bergstrasse, Germany)Dual imaging and photoactivated nanoprobe for controlled cell tracking. Small. 2013 Jan 28; 9(2):222-7.Small2012-09-21T00:00:002012Dual imaging and photoactivated nanoprobe for controlled cell tracking.20949198Issadore D, Shao H, Chung J, Newton A, Pittet M, Weissleder R, Lee HLab on a chipSelf-assembled magnetic filter for highly efficient immunomagnetic separation. Lab Chip. 2011 Jan 07; 11(1):147-51.Lab Chip2010-10-14T00:00:002010Self-assembled magnetic filter for highly efficient immunomagnetic separation.2023-07-31LEE, HAKHO ;SKOG, JOHAN2018-08-02Clinical platform for high-throughput analyses of extracellular vesiclesR01CA229777Principal Investigator20336708Haun JB, Yoon TJ, Lee H, Weissleder RWiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyMagnetic nanoparticle biosensors. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 May-Jun; 2(3):291-304.Wiley Interdiscip Rev Nanomed Nanobiotechnol2010-05-01T00:00:002010Magnetic nanoparticle biosensors.21424441Haun JB, Yoon TJ, Lee H, Weissleder RMethods in molecular biology (Clifton, N.J.)Molecular detection of biomarkers and cells using magnetic nanoparticles and diagnostic magnetic resonance. Methods Mol Biol. 2011; 726:33-49.Methods Mol Biol2011-01-01T00:00:002011Molecular detection of biomarkers and cells using magnetic nanoparticles and diagnostic magnetic resonance.21967150Chung HJ, Reiner T, Budin G, Min C, Liong M, Issadore D, Lee H, Weissleder RACS nanoUbiquitous detection of gram-positive bacteria with bioorthogonal magnetofluorescent nanoparticles. ACS Nano. 2011 Nov 22; 5(11):8834-41.ACS Nano2011-10-10T00:00:002011Ubiquitous detection of gram-positive bacteria with bioorthogonal magnetofluorescent nanoparticles.22745585Ghazani AA, Castro CM, Gorbatov R, Lee H, Weissleder RNeoplasia (New York, N.Y.)Sensitive and direct detection of circulating tumor cells by multimarker µ-nuclear magnetic resonance. Neoplasia. 2012 May; 14(5):388-95.Neoplasia2012-05-01T00:00:002012Sensitive and direct detection of circulating tumor cells by multimarker µ-nuclear magnetic resonance.22043803Liong M, Fernandez-Suarez M, Issadore D, Min C, Tassa C, Reiner T, Fortune SM, Toner M, Lee H, Weissleder RBioconjugate chemistrySpecific pathogen detection using bioorthogonal chemistry and diagnostic magnetic resonance. Bioconjug Chem. 2011 Dec 21; 22(12):2390-4.Bioconjug Chem2011-11-07T00:00:002011Specific pathogen detection using bioorthogonal chemistry and diagnostic magnetic resonance.17330164Lee H, Liu Y, Ham D, Westervelt RMLab on a chipIntegrated cell manipulation system--CMOS/microfluidic hybrid. Lab Chip. 2007 Mar; 7(3):331-7.Lab Chip2007-02-01T00:00:002007Integrated cell manipulation system--CMOS/microfluidic hybrid.19206619Insin N, Tracy JB, Lee H, Zimmer JP, Westervelt RM, Bawendi MGACS nanoIncorporation of iron oxide nanoparticles and quantum dots into silica microspheres. ACS Nano. 2008 Feb; 2(2):197-202.ACS Nano2008-02-01T00:00:002008Incorporation of iron oxide nanoparticles and quantum dots into silica microspheres.20676091Haun JB, Devaraj NK, Hilderbrand SA, Lee H, Weissleder RNature nanotechnologyBioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection. Nat Nanotechnol. 2010 Sep; 5(9):660-5.Nat Nanotechnol2010-08-01T00:00:002010Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection.21780311Liong M, Tassa C, Shaw SY, Lee H, Weissleder RAdvanced materials (Deerfield Beach, Fla.)Multiplexed magnetic labeling amplification using oligonucleotide hybridization. Adv Mater. 2011 Sep 22; 23(36):H254-7.Adv Mater2011-07-22T00:00:002011Multiplexed magnetic labeling amplification using oligonucleotide hybridization.21953810Yoon TJ, Lee H, Shao H, Hilderbrand SA, Weissleder RAdvanced materials (Deerfield Beach, Fla.)Multicore assemblies potentiate magnetic properties of biomagnetic nanoparticles. Adv Mater. 2011 Nov 02; 23(41):4793-7.Adv Mater2011-09-26T00:00:002011Multicore assemblies potentiate magnetic properties of biomagnetic nanoparticles.2023-07-31CASTRO, CESAR M;DINULESCU, DANIELA M;LEE, HAKHO ;SKOG, JOHAN2018-09-01Early Detection through Novel OCEAN Technology - Ovarian Cancer Exosomal Analysis with NanoplasmonicsU01CA233360Principal Investigator19554581Lee H, Yoon TJ, Weissleder RAngewandte Chemie (International ed. in English)Ultrasensitive detection of bacteria using core-shell nanoparticles and an NMR-filter system. Angew Chem Int Ed Engl. 2009; 48(31):5657-60.Angew Chem Int Ed Engl2009-01-01T00:00:002009Ultrasensitive detection of bacteria using core-shell nanoparticles and an NMR-filter system.22113923Agasti SS, Liong M, Tassa C, Chung HJ, Shaw SY, Lee H, Weissleder RAngewandte Chemie (International ed. in English)Supramolecular host-guest interaction for labeling and detection of cellular biomarkers. Angew Chem Int Ed Engl. 2012 Jan 09; 51(2):450-4.Angew Chem Int Ed Engl2011-11-24T00:00:002011Supramolecular host-guest interaction for labeling and detection of cellular biomarkers.Authorship 1099952D058185Chemicals & Drugs1523240.830076Magnetite NanoparticlesD009360Anatomy3569090.591918Neoplastic Cells, CirculatingD046210DevicesProcedures3008270.593214Microfluidic Analytical TechniquesD015374DevicesProcedures3096650.615652Biosensing TechniquesD009682PhenomenaProcedures116437570.463039Magnetic Resonance SpectroscopyMedicineNeurologyRadiologySurgeryHematology/OncologyGeneticsBoston Children's HospitalHarvard Medical SchoolMassachusetts General HospitalMassachusetts Institute of TechnologyRHK3RainerKohlerRainer H. Kohler, Ph.D.42.37730000000000-71.0525000000000075300Kohler, RainerResearch Associate in Radiology1136selected publications1.188460.00242073142research areas4.320330.022336416coauthor of37.72763.400360similar toCMC37CesarCastroCesar Martin Castro, M.D.42.36241700000000-71.0689370000000085844Castro, CesarAssociate Professor of MedicineKristaDongKrista Louise Dong, M.D.42.37730000000000-71.0525000000000034982Dong, KristaMember of the Faculty of MedicineCV15ClaudioVinegoniClaudio Vinegoni, Ph.D.42.37730000000000-71.0525000000000073737Vinegoni, ClaudioAssistant Professor of RadiologyDEI1DonIngberDon Ingber, M.D.,Ph.D.42.33773240000000-71.1051962000000029942Ingber, DonJudah Folkman Professor of Vascular Biology in the Department of SurgeryHY19HushanYuanHushan Yuan, Ph.D.42.37730000000000-71.052500000000001981Yuan, HushanAssistant Professor of RadiologyMT2MehmetTonerMehmet Toner, Ph.D.42.37904200000000-71.051481000000003525Toner, MehmetHelen Andrus Benedict Professor of SurgeryMN44MatthiasNahrendorfMatthias Nahrendorf, M.D.42.37730000000000-71.052500000000003918Nahrendorf, MatthiasProfessor of RadiologyAA220ArezouGhazaniArezou A Ghazani, Ph.D.42.33710500000000-71.1023170000000032129Ghazani, ArezouAssistant Professor of MedicineRSL4RobertLangerRobert S. Langer, Sc.D.42.36053900000000-71.0900740000000026380Langer, RobertSenior Lecturer on Surgery, Part-timeRW4RalphWeisslederRalph Weissleder, M.D., Ph.D.42.36125700000000-71.0655270000000048432Weissleder, RalphThrall Family Professor of RadiologyHI32HyungsoonImHyungsoon Im, Ph.D.102992Im, HyungsoonAssociate Professor of RadiologyAuthorship 1483672true1Professor of RadiologyProfessor of Radiologytrue1Assistant Professor of RadiologyAssistant Professor of Radiologytrue1Research Associate in RadiologyResearch Associate in Radiologytrue1Assistant Professor of RadiologyAssistant Professor of Radiology2021-08-31LEE, HAKHO2019-09-30High-throughput Integrated Magneto-electrochemical Exosome (HiMEX) platform to identify neurodevelopmental markers associated with pre and postnatal oxycodone exposureR21DA049577Principal Investigator2025-02-28CARTER, BOB S ;LEE, HAKHO2020-03-01Imaging and Liquid Biopsy for Glioma Diagnosis and Treatment MonitoringR01CA239078Co-Principal Investigator2025-06-30CARTER, BOB S ;LEE, HAKHO2020-07-01Standardized Molecular Analyses of Glioma EVsR01CA237500Co-Principal Investigatortrue1Associate Professor of MedicineAssociate Professor of Medicine2025-07-31CASTRO, CESAR M ;LEE, HAKHO2021-08-06High throughput nanoplasmonic exosome testing (NEXT) of immunotherapies in bladder cancerR01CA264363Co-Principal InvestigatorAuthorship 3135164dac8834DanielChiuDaniel Chiu, M.D.206961Chiu, DanielClinical Fellow in NeurologyAuthorship 4325292true1Associate Professor of RadiologyAssociate Professor of RadiologyRagon Institute of MGH, MIT and Harvardtrue1Clinical Fellow in NeurologyClinical Fellow in Neurologytrue1William and Elizabeth Sweet Professor of NeurosurgeryWilliam and Elizabeth Sweet Professor of Neurosurgerytrue1Thrall Family Professor of RadiologyThrall Family Professor of Radiologytrue1Helen Andrus Benedict Professor of SurgeryHelen Andrus Benedict Professor of Surgerytrue1Senior Lecturer on Surgery, Part-timeSenior Lecturer on Surgery, Part-timetrue1Member of the Faculty of MedicineMember of the Faculty of Medicine2028-06-30CASTRO, CESAR M2023-07-01Composing CODAs to cervical cancer screening through an integrated CRISPR and fluorescent nucleic acid approachU01CA2798582028-08-31LEE, HAKHO2023-09-19Expanding early cancer detection with high throughput OCEANA - Ovarian Cancer Exosome Analysis with Nanoplasmonic ArrayU01CA284982Principal InvestigatorCo-Principal Investigatortrue1Professor of RadiologyProfessor of Radiologytrue1Assistant Professor of MedicineAssistant Professor of Medicinetrue1Judah Folkman Professor of Vascular Biology in the Department of SurgeryJudah Folkman Professor of Vascular Biology in the Department of SurgeryAuthorship 2490574Authorship 2547694Neurosurgery23835814Castro CM, Ghazani AA, Chung J, Shao H, Issadore D, Yoon TJ, Weissleder R, Lee HLab on a chipMiniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells. Lab Chip. 2014 Jan 07; 14(1):14-23.Lab Chip2013-07-08T00:00:002013Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells.Authorship 2402993Authorship 25109410Authorship 715336Authorship 2599751Authorship 4223281Authorship 4577936Authorship 5556763Authorship 872081Authorship 3995583Authorship 5737701Authorship 2623017Authorship 2060654Authorship 2743083Authorship 2608857Authorship 4552483Authorship 4564466Authorship 3504339Authorship 2469077Authorship 1717726Authorship 2873696Authorship 8210248Authorship 876670626980325Im H, Park YI, Pathania D, Castro CM, Weissleder R, Lee HLab on a chipDigital diffraction detection of protein markers for avian influenza. Lab Chip. 2016 Apr 21; 16(8):1340-5.Lab Chip2016-04-21T00:00:002016Digital diffraction detection of protein markers for avian influenza.2Assistant Professor1Associate Professor6Fellow or Post Doc0Full Professor3Lecturer5Other FacultyAuthorship 646137Authorship 53897782018-07-31LEE, HAKHO2016-05-01Multiplexed exosome analyses with DNA barcodingR21CA2053222017-09-30LEE, HAKHO2012-04-16MAGNETIC NANOSENSORS FOR BIOMEDICAL ANALYSES OF MICROVESICLESR01HL113156Principal InvestigatorPrincipal InvestigatorAuthorship 3871415Authorship 2112844Authorship 265524BSC3BobCarterBob S Carter, M.D.,Ph.D.24752Carter, BobWilliam and Elizabeth Sweet Professor of NeurosurgeryAuthorship 955243528134385Hong S, Park KS, Weissleder R, Castro CM, Lee HChemical communications (Cambridge, England)Facile silicification of plastic surface for bioassays. Chem Commun (Camb). 2017 Feb 09; 53(13):2134-2137.Chem Commun (Camb)2017-02-09T00:00:002017Facile silicification of plastic surface for bioassays.21351804Haun JB, Devaraj NK, Marinelli BS, Lee H, Weissleder RACS nanoProbing intracellular biomarkers and mediators of cell activation using nanosensors and bioorthogonal chemistry. ACS Nano. 2011 Apr 26; 5(4):3204-13.ACS Nano2011-03-08T00:00:002011Probing intracellular biomarkers and mediators of cell activation using nanosensors and bioorthogonal chemistry.18607350Lee H, Sun E, Ham D, Weissleder RNature medicineChip-NMR biosensor for detection and molecular analysis of cells. Nat Med. 2008 Aug; 14(8):869-74.Nat Med2008-07-06T00:00:002008Chip-NMR biosensor for detection and molecular analysis of cells.Authorship 1005017428745363Im H, Lee K, Weissleder R, Lee H, Castro CMLab on a chipNovel nanosensing technologies for exosome detection and profiling. Lab Chip. 2017 08 22; 17(17):2892-2898.Lab Chip2017-08-22T00:00:002017Novel nanosensing technologies for exosome detection and profiling.21346169Haun JB, Castro CM, Wang R, Peterson VM, Marinelli BS, Lee H, Weissleder RScience translational medicineMicro-NMR for rapid molecular analysis of human tumor samples. Sci Transl Med. 2011 Feb 23; 3(71):71ra16.Sci Transl Med2011-02-23T00:00:002011Micro-NMR for rapid molecular analysis of human tumor samples.21547317Issadore D, Min C, Liong M, Chung J, Weissleder R, Lee HLab on a chipMiniature magnetic resonance system for point-of-care diagnostics. Lab Chip. 2011 Jul 07; 11(13):2282-7.Lab Chip2011-05-05T00:00:002011Miniature magnetic resonance system for point-of-care diagnostics.22762250Min C, Shao H, Liong M, Yoon TJ, Weissleder R, Lee HACS nanoMechanism of magnetic relaxation switching sensing. ACS Nano. 2012 Aug 28; 6(8):6821-8.ACS Nano2012-07-10T00:00:002012Mechanism of magnetic relaxation switching sensing.Authorship 10221701429067383Min C, Park J, Mun JK, Lim Y, Min J, Lim JW, Kang DM, Ahn HK, Shin TH, Cheon J, Lee HS, Weissleder R, Castro CM, Lee HLab on a chipIntegrated microHall magnetometer to measure the magnetic properties of nanoparticles. Lab Chip. 2017 11 21; 17(23):4000-4007.Lab Chip2017-11-21T00:00:002017Integrated microHall magnetometer to measure the magnetic properties of nanoparticles.22424443Peterson VM, Castro CM, Lee H, Weissleder RACS nanoOrthogonal amplification of nanoparticles for improved diagnostic sensing. ACS Nano. 2012 Apr 24; 6(4):3506-13.ACS Nano2012-03-23T00:00:002012Orthogonal amplification of nanoparticles for improved diagnostic sensing.22764208Issadore D, Chung J, Shao H, Liong M, Ghazani AA, Castro CM, Weissleder R, Lee HScience translational medicineUltrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector. Sci Transl Med. 2012 Jul 04; 4(141):141ra92.Sci Transl Med2012-07-04T00:00:002012Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector.22744868Budin G, Chung HJ, Lee H, Weissleder RAngewandte Chemie (International ed. in English)A magnetic Gram stain for bacterial detection. Angew Chem Int Ed Engl. 2012 Jul 27; 51(31):7752-5.Angew Chem Int Ed Engl2012-06-28T00:00:002012A magnetic Gram stain for bacterial detection.20859943Liong M, Shao H, Haun JB, Lee H, Weissleder RAdvanced materials (Deerfield Beach, Fla.)Carboxymethylated polyvinyl alcohol stabilizes doped ferrofluids for biological applications. Adv Mater. 2010 Dec 01; 22(45):5168-72.Adv Mater2010-12-01T00:00:002010Carboxymethylated polyvinyl alcohol stabilizes doped ferrofluids for biological applications.19620715Lee H, Yoon TJ, Figueiredo JL, Swirski FK, Weissleder RProceedings of the National Academy of Sciences of the United States of AmericaRapid detection and profiling of cancer cells in fine-needle aspirates. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12459-64.Proc Natl Acad Sci U S A2009-07-20T00:00:002009Rapid detection and profiling of cancer cells in fine-needle aspirates.21495138Yoon TJ, Lee H, Shao H, Weissleder RAngewandte Chemie (International ed. in English)Highly magnetic core-shell nanoparticles with a unique magnetization mechanism. Angew Chem Int Ed Engl. 2011 May 09; 50(20):4663-6.Angew Chem Int Ed Engl2011-04-14T00:00:002011Highly magnetic core-shell nanoparticles with a unique magnetization mechanism.23184773Chung J, Shao H, Reiner T, Issadore D, Weissleder R, Lee HAdvanced healthcare materialsMicrofluidic cell sorter (µFCS) for on-chip capture and analysis of single cells. Adv Healthc Mater. 2012 Jul; 1(4):432-6.Adv Healthc Mater2012-05-02T00:00:002012Microfluidic cell sorter (µFCS) for on-chip capture and analysis of single cells.19461894Wildgruber M, Lee H, Chudnovskiy A, Yoon TJ, Etzrodt M, Pittet MJ, Nahrendorf M, Croce K, Libby P, Weissleder R, Swirski FKPloS oneMonocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors. PLoS One. 2009 May 22; 4(5):e5663.PLoS One2009-05-22T00:00:002009Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors.21962084Ullal AV, Reiner T, Yang KS, Gorbatov R, Min C, Issadore D, Lee H, Weissleder RACS nanoNanoparticle-mediated measurement of target-drug binding in cancer cells. ACS Nano. 2011 Nov 22; 5(11):9216-24.ACS Nano2011-10-13T00:00:002011Nanoparticle-mediated measurement of target-drug binding in cancer cells.22272219Shao H, Min C, Issadore D, Liong M, Yoon TJ, Weissleder R, Lee HTheranosticsMagnetic Nanoparticles and microNMR for Diagnostic Applications. Theranostics. 2012; 2(1):55-65.Theranostics2012-01-01T00:00:002012Magnetic Nanoparticles and microNMR for Diagnostic Applications.23142818Shao H, Chung J, Balaj L, Charest A, Bigner DD, Carter BS, Hochberg FH, Breakefield XO, Weissleder R, Lee HNature medicineProtein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy. Nat Med. 2012 Dec; 18(12):1835-40.Nat Med2012-11-11T00:00:002012Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy.