Brain research. Developmental brain research
Spinocerebellar mossy fiber terminal topography in the NR2C/PKC gamma double mutant cerebellum. Brain Res Dev Brain Res. 1996 Nov 22; 97(1):138-42.
Spinocerebellar mossy fiber terminal topography in the NR2C/PKC gamma double mutant cerebellum.
Steidl U, Steidl C, Ebralidze A, Chapuy B, Han HJ, Will B, Rosenbauer F, Becker A, Wagner K, Koschmieder S, Kobayashi S, Costa DB, Schulz T, O'Brien KB, Verhaak RG, Delwel R, Haase D, Trümper L, Krauter J, Kohwi-Shigematsu T, Griesinger F, Tenen DG
A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia. J Clin Invest. 2007 Sep; 117(9):2611-20.
A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia.
Guibal FC, Alberich-Jorda M, Hirai H, Ebralidze A, Levantini E, Di Ruscio A, Zhang P, Santana-Lemos BA, Neuberg D, Wagers AJ, Rego EM, Tenen DG
Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia. Blood. 2009 Dec 24; 114(27):5415-25.
Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.
Grigorian MS, Ebralidze AK, Tyl'chinskii EM, Revazova ES, Senin VM, Lukanidin EM
[Study of transcription of the DNA sequence of a mts271 clone in various tumor and normal mouse cells]. Genetika. 1989 Jun; 25(6):993-1000.
[Study of transcription of the DNA sequence of a mts271 clone in various tumor and normal mouse cells].
Churikov NA, Ebralidze AK, Polukarova LG
[Molecular genetic study of the cut locus of Drosophila melanogaster. V. The suffix sequence found in the locus is involved in the 3'-end maturation of different Drosophila mRNAs]. Genetika. 1987 Oct; 23(10):1807-22.
[Molecular genetic study of the cut locus of Drosophila melanogaster. V. The suffix sequence found in the locus is involved in the 3'-end maturation of different Drosophila mRNAs].
Levantini E, Lee S, Radomska HS, Hetherington CJ, Alberich-Jorda M, Amabile G, Zhang P, Gonzalez DA, Zhang J, Basseres DS, Wilson NK, Koschmieder S, Huang G, Zhang DE, Ebralidze AK, Bonifer C, Okuno Y, Gottgens B, Tenen DG
RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element. EMBO J. 2011 Aug 26; 30(19):4059-70.
RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element.
Ebralidze AK, Tul'chinskii EM, Grigorian MS, Senin VM, Lukanidin EM
[Isolation of cDNA clones which are specifically transcribed in metastatic and nonmetastatic murine tumors]. Genetika. 1989 May; 25(5):932-6.
[Isolation of cDNA clones which are specifically transcribed in metastatic and nonmetastatic murine tumors].
Professor of Stem Cell and Regenerative Biology and Gerald and Darlene Jordan Professor of Medicine
David G. Nathan Distinguished Professor of Pediatrics
Shattuck Professor of Pathological Anatomy
Professor of Stem Cell and Regenerative Biology and Grousbeck Professor of Pediatrics, Harvard Medical School
Associate Professor of Medicine, Part-time
Virginia and D.K. Ludwig Professor of Microbiology and Immunobiology, Emeritus
Canesin G, Di Ruscio A, Li M, Ummarino S, Hedblom A, Choudhury R, Krzyzanowska A, Csizmadia E, Palominos M, Stiehm A, Ebralidze A, Chen SY, Bassal MA, Zhao P, Tolosano E, Hurley L, Bjartell A, Tenen DG, Wegiel B
Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases. Cell Rep. 2020 09 22; 32(12):108181.
Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases.
Trinh BQ, Ummarino S, Zhang Y, Ebralidze AK, Bassal MA, Nguyen TM, Heller G, Coffey R, Tenen DE, van der Kouwe E, Fabiani E, Gurnari C, Wu CS, Angarica VE, Yang H, Chen S, Zhang H, Thurm AR, Marchi F, Levantini E, Staber PB, Zhang P, Voso MT, Pandolfi PP, Kobayashi SS, Chai L, Di Ruscio A, Tenen DG
Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML. Blood. 2021 10 14; 138(15):1331-1344.
Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML.
van der Kouwe E, Heller G, Czibere A, Pulikkan JA, Agreiter C, Castilla LH, Delwel R, Di Ruscio A, Ebralidze AK, Forte M, Grebien F, Heyes E, Kazianka L, Klinger J, Kornauth C, Le T, Lind K, Barbosa IAM, Pemovska T, Pichler A, Schmolke AS, Schweicker CM, Sill H, Sperr WR, Spittler A, Surapally S, Trinh BQ, Valent P, Vanura K, Welner RS, Zuber J, Tenen DG, Staber PB
Core-binding factor leukemia hijacks the T-cell-prone PU.1 antisense promoter. Blood. 2021 10 14; 138(15):1345-1358.
Core-binding factor leukemia hijacks the T-cell-prone PU.1 antisense promoter.
Ummarino S, Hausman C, Gaggi G, Rinaldi L, Bassal MA, Zhang Y, Seelam AJ, Kobayashi IS, Borchiellini M, Ebralidze AK, Ghinassi B, Trinh BQ, Kobayashi SS, Di Ruscio A
NAD Modulates DNA Methylation and Cell Differentiation. Cells. 2021 11 02; 10(11).
NAD Modulates DNA Methylation and Cell Differentiation.
Esposito CL, Autiero I, Sandomenico A, Li H, Bassal MA, Ibba ML, Wang D, Rinaldi L, Ummarino S, Gaggi G, Borchiellini M, Swiderski P, Ruvo M, Catuogno S, Ebralidze AK, Kortylewski M, de Franciscis V, Di Ruscio A
Targeted systematic evolution of an RNA platform neutralizing DNMT1 function and controlling DNA methylation. Nat Commun. 2023 01 06; 14(1):99.
Targeted systematic evolution of an RNA platform neutralizing DNMT1 function and controlling DNA methylation.
Liu YV, Suryatenggara J, Wong H, Jayasinghe MK, Tang JP, Tan HK, Kwon J, Zhou Q, Ummarino S, Ebralidze AK, Le MTN, Doench JG, Chai L, Benoukraf T, Hiwase D, Thomas D, Di Ruscio A, Tenen DG, Bassal MA
Methylation Mesa define functional regulatory elements for targeted gene activation. Res Sq. 2024 Oct 16.
Methylation Mesa define functional regulatory elements for targeted gene activation.
Furuhashi K, Kakiuchi M, Ueda R, Oda H, Ummarino S, Ebralidze AK, Bassal MA, Meng C, Sato T, Lyu J, Han MG, Maruyama S, Watanabe Y, Sawa Y, Kato D, Wake H, Reizis B, Frangos JA, Owens DM, Tenen DG, Ghiran IC, Robson SC, Fujisaki J
Bone marrow niches orchestrate stem-cell hierarchy and immune tolerance. Nature. 2025 02; 638(8049):206-215.
Bone marrow niches orchestrate stem-cell hierarchy and immune tolerance.
Ummarino S, Poluben L, Ebralidze AK, Autiero I, Zhang Y, Paniza T, Deshpande M, Rinaldi L, Lee JD, Bassal MA, Trinh BQ, Balk SP, Flaumenhaft R, Gerhardt J, Mirkin SM, Tenen DG, Di Ruscio A
RNAs anchoring replication complex control initiation and firing of DNA replication. Res Sq. 2025 Jan 28.
RNAs anchoring replication complex control initiation and firing of DNA replication.
Zhang H, Alberich-Jorda M, Amabile G, Yang H, Staber PB, Di Ruscio A, Diruscio A, Welner RS, Ebralidze A, Zhang J, Levantini E, Lefebvre V, Valk PJ, Delwel R, Hoogenkamp M, Nerlov C, Cammenga J, Saez B, Scadden DT, Bonifer C, Ye M, Tenen DG
Sox4 is a key oncogenic target in C/EBPa mutant acute myeloid leukemia. Cancer Cell. 2013 Nov 11; 24(5):575-88.
Sox4 is a key oncogenic target in C/EBPa mutant acute myeloid leukemia.
Di Ruscio A, Ebralidze AK, Benoukraf T, Amabile G, Goff LA, Terragni J, Figueroa ME, De Figueiredo Pontes LL, Alberich-Jorda M, Zhang P, Wu M, D'Alò F, Melnick A, Leone G, Ebralidze KK, Pradhan S, Rinn JL, Tenen DG
DNMT1-interacting RNAs block gene-specific DNA methylation. Nature. 2013 Nov 21; 503(7476):371-6.
DNMT1-interacting RNAs block gene-specific DNA methylation.
Gaggi G, Patiño-Mercau JR, Borchiellini M, Li M, Rinaldi L, Maroni G, D'Onghia D, Kobayashi SS, Bassal MA, Habib NA, Medina PP, Di Baldassarre A, Ghinassi B, Ebralidze AK, Ummarino S, Tenen DG, Di Ruscio A
bioRxiv : the preprint server for biology
Small activating RNA AW1-51 (CEBPA-51) elicits targeted DNA demethylation to promote gene activation. bioRxiv. 2025 Sep 30.
Small activating RNA AW1-51 (CEBPA-51) elicits targeted DNA demethylation to promote gene activation.
Staber PB, Zhang P, Ye M, Welner RS, Levantini E, Di Ruscio A, Ebralidze AK, Bach C, Zhang H, Zhang J, Vanura K, Delwel R, Yang H, Huang G, Tenen DG
The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells. Blood. 2014 Oct 09; 124(15):2391-9.
The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.
Amabile G, Di Ruscio A, Müller F, Welner RS, Yang H, Ebralidze AK, Zhang H, Levantini E, Qi L, Martinelli G, Brummelkamp T, Le Beau MM, Figueroa ME, Bock C, Tenen DG
Dissecting the role of aberrant DNA methylation in human leukaemia. Nat Commun. 2015 May 22; 6:7091.
Dissecting the role of aberrant DNA methylation in human leukaemia.
Bararia D, Kwok HS, Welner RS, Numata A, Sárosi MB, Yang H, Wee S, Tschuri S, Ray D, Weigert O, Levantini E, Ebralidze AK, Gunaratne J, Tenen DG
Acetylation of C/EBPa inhibits its granulopoietic function. Nat Commun. 2016 Mar 23; 7:10968.
Acetylation of C/EBPa inhibits its granulopoietic function.
Ebralidze AK, Rossi DJ, Tonegawa S, Slater NT
The Journal of neuroscience : the official journal of the Society for Neuroscience
Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene. J Neurosci. 1996 Aug 15; 16(16):5014-25.
Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene.
The suffix sequence is involved in processing the 3' ends of different mRNAs in Drosophila melanogaster. EMBO J. 1986 Sep; 5(9):2341-2347.
The suffix sequence is involved in processing the 3' ends of different mRNAs in Drosophila melanogaster.
Steidl U, Rosenbauer F, Verhaak RG, Gu X, Ebralidze A, Otu HH, Klippel S, Steidl C, Bruns I, Costa DB, Wagner K, Aivado M, Kobbe G, Valk PJ, Passegué E, Libermann TA, Delwel R, Tenen DG
Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells. Nat Genet. 2006 Nov; 38(11):1269-77.
Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells.
O'Brien KB, Alberich-Jordà M, Yadav N, Kocher O, Diruscio A, Ebralidze A, Levantini E, Sng NJ, Bhasin M, Caron T, Kim D, Steidl U, Huang G, Halmos B, Rodig SJ, Bedford MT, Tenen DG, Kobayashi S
CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development. 2010 Jul; 137(13):2147-56.
CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells.
Does (CUG)n repeat in DMPK mRNA 'paint' chromosome 19 to suppress distant genes to create the diverse phenotype of myotonic dystrophy?: A new hypothesis of long-range cis autosomal inactivation. Neurogenetics. 2001 Mar; 3(2):59-67.
Does (CUG)n repeat in DMPK mRNA 'paint' chromosome 19 to suppress distant genes to create the diverse phenotype of myotonic dystrophy?: A new hypothesis of long-range cis autosomal inactivation.
Ebralidze A, Wang Y, Petkova V, Ebralidse K, Junghans RP
RNA leaching of transcription factors disrupts transcription in myotonic dystrophy. Science. 2004 Jan 16; 303(5656):383-7.
RNA leaching of transcription factors disrupts transcription in myotonic dystrophy.
Tulchinsky EM, Grigorian MS, Ebralidze AK, Milshina NI, Lukanidin EM
Structure of gene mts1, transcribed in metastatic mouse tumor cells. Gene. 1990 Mar 15; 87(2):219-23.
Structure of gene mts1, transcribed in metastatic mouse tumor cells.
Ebralidze AK, Guibal FC, Steidl U, Zhang P, Lee S, Bartholdy B, Jorda MA, Petkova V, Rosenbauer F, Huang G, Dayaram T, Klupp J, O'Brien KB, Will B, Hoogenkamp M, Borden KL, Bonifer C, Tenen DG
PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element. Genes Dev. 2008 Aug 01; 22(15):2085-92.
PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.
Amabile G, Welner RS, Nombela-Arrieta C, D'Alise AM, Di Ruscio A, Ebralidze AK, Kraytsberg Y, Ye M, Kocher O, Neuberg DS, Khrapko K, Silberstein LE, Tenen DG
In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells. Blood. 2013 Feb 21; 121(8):1255-64.
In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells.
Cardenas MA, Vorovich MF, Ebralidze AK, Chertov OIu, Lukanidin EM
[Preparation of recombinant metastazin and characteristics of it]. Bioorg Khim. 1993 Apr; 19(4):420-6.
[Preparation of recombinant metastazin and characteristics of it].
Gonzalez D, Luyten A, Bartholdy B, Zhou Q, Kardosova M, Ebralidze A, Swanson KD, Radomska HS, Zhang P, Kobayashi SS, Welner RS, Levantini E, Steidl U, Chong G, Collombet S, Choi MH, Friedman AD, Scott LM, Alberich-Jorda M, Tenen DG
ZNF143 protein is an important regulator of the myeloid transcription factor C/EBPa. J Biol Chem. 2017 11 17; 292(46):18924-18936.
ZNF143 protein is an important regulator of the myeloid transcription factor C/EBPa.
Ebralidze A, Tulchinsky E, Grigorian M, Afanasyeva A, Senin V, Revazova E, Lukanidin E
Isolation and characterization of a gene specifically expressed in different metastatic cells and whose deduced gene product has a high degree of homology to a Ca2+-binding protein family. Genes Dev. 1989 Jul; 3(7):1086-93.
Isolation and characterization of a gene specifically expressed in different metastatic cells and whose deduced gene product has a high degree of homology to a Ca2+-binding protein family.
Regulatory role of long noncoding RNAs in normal and cancer cells
Poss KD, Thomas MJ, Ebralidze AK, O'Dell TJ, Tonegawa S
Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. Neuron. 1995 Oct; 15(4):867-73.
Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice.
Grigorian MS, Tulchinsky EM, Zain S, Ebralidze AK, Kramerov DA, Kriajevska MV, Georgiev GP, Lukanidin EM
The mts1 gene and control of tumor metastasis. Gene. 1993 Dec 15; 135(1-2):229-38.
The mts1 gene and control of tumor metastasis.
Tul'chinskii EM, Ebralidze AK, Grigorian MS, Mil'shchina NV, Lukanidin EM
[Structure of the mts271 gene, coding a new calcium-binding protein]. Genetika. 1989 Jul; 25(7):1150-9.
[Structure of the mts271 gene, coding a new calcium-binding protein].
Alberich-Jordà M, Wouters B, Balastik M, Shapiro-Koss C, Zhang H, Di Ruscio A, DiRuscio A, Radomska HS, Ebralidze AK, Amabile G, Ye M, Zhang J, Lowers I, Avellino R, Melnick A, Figueroa ME, Valk PJ, Delwel R, Tenen DG
C/EBP? deregulation results in differentiation arrest in acute myeloid leukemia. J Clin Invest. 2012 Dec; 122(12):4490-504.
C/EBP? deregulation results in differentiation arrest in acute myeloid leukemia.
Hoogenkamp M, Krysinska H, Ingram R, Huang G, Barlow R, Clarke D, Ebralidze A, Zhang P, Tagoh H, Cockerill PN, Tenen DG, Bonifer C
The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis. Mol Cell Biol. 2007 Nov; 27(21):7425-38.
The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis.