BMPs mediate lateral inhibition at successive stages in feather tract development. Development. 1998 Oct; 125(19):3775-87.
BMPs mediate lateral inhibition at successive stages in feather tract development.
Functionally distinct isoforms of the CRE-BP DNA-binding protein mediate activity of a T-cell-specific enhancer. Mol Cell Biol. 1992 Feb; 12(2):747-57.
Functionally distinct isoforms of the CRE-BP DNA-binding protein mediate activity of a T-cell-specific enhancer.
Nelson CE, Morgan BA, Burke AC, Laufer E, DiMambro E, Murtaugh LC, Gonzales E, Tessarollo L, Parada LF, Tabin C
Analysis of Hox gene expression in the chick limb bud. Development. 1996 May; 122(5):1449-66.
Analysis of Hox gene expression in the chick limb bud.
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Manipulating gene expression with replication-competent retroviruses. Methods Cell Biol. 1996; 51:185-218.
Manipulating gene expression with replication-competent retroviruses.
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Modeling recent human evolution in mice by expression of a selected EDAR variant. Cell. 2013 Feb 14; 152(4):691-702.
Modeling recent human evolution in mice by expression of a selected EDAR variant.
Melanocortin receptor function in the dermal papilla of the hair follicle
Enshell-Seijffers D, Lindon C, Wu E, Taketo MM, Morgan BA
Proceedings of the National Academy of Sciences of the United States of America
Beta-catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21564-9.
Beta-catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching.
Delimiting regulatory sequences of the Drosophila melanogaster Ddc gene. Mol Cell Biol. 1986 Dec; 6(12):4548-57.
Delimiting regulatory sequences of the Drosophila melanogaster Ddc gene.
A novel and major isoform of tyrosine hydroxylase in Drosophila is generated by alternative RNA processing. J Biol Chem. 1994 Oct 21; 269(42):26559-67.
A novel and major isoform of tyrosine hydroxylase in Drosophila is generated by alternative RNA processing.
Methods of identifying dermal papilla cell
Methods of identifying dermal papilla cell. 2009.
The ectodysplasin pathway in feather tract development. Development. 2005 Mar; 132(5):863-72.
The ectodysplasin pathway in feather tract development.
Gao J, DeRouen MC, Chen CH, Nguyen M, Nguyen NT, Ido H, Harada K, Sekiguchi K, Morgan BA, Miner JH, Oro AE, Marinkovich MP
Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev. 2008 Aug 01; 22(15):2111-24.
Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis.
Distinct stem cell populations regenerate the follicle and interfollicular epidermis. Dev Cell. 2005 Dec; 9(6):855-61.
Distinct stem cell populations regenerate the follicle and interfollicular epidermis.
Upending the hair follicle. Nat Genet. 2006 Mar; 38(3):273-4.
Levy V, Lindon C, Zheng Y, Harfe BD, Morgan BA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Epidermal stem cells arise from the hair follicle after wounding. FASEB J. 2007 May; 21(7):1358-66.
Epidermal stem cells arise from the hair follicle after wounding.
Development (Cambridge, England). Supplement
Hox genes and growth: early and late roles in limb bud morphogenesis. Dev Suppl. 1994; 181-6.
Hox genes and growth: early and late roles in limb bud morphogenesis.
Hox genes and the evolution of vertebrate axial morphology. Development. 1995 Feb; 121(2):333-46.
Hox genes and the evolution of vertebrate axial morphology.
Morgan BA, Bouquin N, Merrill GF, Johnston LH
A yeast transcription factor bypassing the requirement for SBF and DSC1/MBF in budding yeast has homology to bacterial signal transduction proteins. EMBO J. 1995 Nov 15; 14(22):5679-89.
A yeast transcription factor bypassing the requirement for SBF and DSC1/MBF in budding yeast has homology to bacterial signal transduction proteins.
Current opinion in genetics & development
The role of homeobox genes in limb development. Curr Opin Genet Dev. 1993 Aug; 3(4):668-74.
The role of homeobox genes in limb development.
Laufer E, Nelson CE, Johnson RL, Morgan BA, Tabin C
Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud. Cell. 1994 Dec 16; 79(6):993-1003.
Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud.
Stage-specific effects of sonic hedgehog expression in the epidermis. Dev Biol. 1998 Sep 01; 201(1):1-12.
Stage-specific effects of sonic hedgehog expression in the epidermis.
Molecular genetics of eccrine sweat gland development
Enshell-Seijffers D, Lindon C, Kashiwagi M, Morgan BA
beta-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair. Dev Cell. 2010 Apr 20; 18(4):633-42.
beta-catenin activity in the dermal papilla regulates morphogenesis and regeneration of hair.
Progress in clinical and biological research
The role of Hox genes in limb development. Prog Clin Biol Res. 1993; 383A:1-9.
The role of Hox genes in limb development.
Kamberov YG, Guhan SM, DeMarchis A, Jiang J, Wright SS, Morgan BA, Sabeti PC, Tabin CJ, Lieberman DE
Comparative evidence for the independent evolution of hair and sweat gland traits in primates. J Hum Evol. 2018 12; 125:99-105.
Comparative evidence for the independent evolution of hair and sweat gland traits in primates.
Harvard T.H. Chan School of Public Health
Professor of Immunology and Infectious Diseases
David Wesley Gaiser Professor of Biological Chemistry and Molecular Pharmacology
George Jacob and Jacqueline Hazel Leder Professor of Genetics
Redox control of AP-1-like factors in yeast and beyond. Oncogene. 2001 Apr 30; 20(19):2336-46.
Redox control of AP-1-like factors in yeast and beyond.
Professor of Stem Cell and Regenerative Biology and Grousbeck Professor of Pediatrics, Harvard Medical School
James Stillman Professor of Developmental Biology
Shibata S, Kashiwagi M, Morgan BA, Georgopoulos K
Functional interactions between Mi-2ß and AP1 complexes control response and recovery from skin barrier disruption. J Exp Med. 2020 03 02; 217(3).
Functional interactions between Mi-2ß and AP1 complexes control response and recovery from skin barrier disruption.
Development and maintenance of plantar skin
Kashiwagi M, Figueroa DS, Ay F, Morgan BA, Georgopoulos K
A double-negative thymocyte-specific enhancer augments Notch1 signaling to direct early T cell progenitor expansion, lineage restriction and ß-selection. Nat Immunol. 2022 11; 23(11):1628-1643.
A double-negative thymocyte-specific enhancer augments Notch1 signaling to direct early T cell progenitor expansion, lineage restriction and ß-selection.
Knöringer K, Groh C, Krämer L, Stein KC, Hansen KG, Zimmermann J, Morgan B, Herrmann JM, Frydman J, Boos F
The unfolded protein response of the endoplasmic reticulum supports mitochondrial biogenesis by buffering nonimported proteins. Mol Biol Cell. 2023 09 01; 34(10):ar95.
The unfolded protein response of the endoplasmic reticulum supports mitochondrial biogenesis by buffering nonimported proteins.
Hu Y, Salgado Figueroa D, Zhang Z, Veselits M, Bhattacharyya S, Kashiwagi M, Clark MR, Morgan BA, Ay F, Georgopoulos K
Lineage-specific 3D genome organization is assembled at multiple scales by IKAROS. Cell. 2023 11 22; 186(24):5269-5289.e22.
Lineage-specific 3D genome organization is assembled at multiple scales by IKAROS.
Epigenetic regulation of epidermal proinflammatory responses
Histone H4 and the maintenance of genome integrity. Genes Dev. 1995 Jul 15; 9(14):1716-27.
Histone H4 and the maintenance of genome integrity.
Shieh JC, Wilkinson MG, Buck V, Morgan BA, Makino K, Millar JB
The Mcs4 response regulator coordinately controls the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle. Genes Dev. 1997 Apr 15; 11(8):1008-22.
The Mcs4 response regulator coordinately controls the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle.
Barañano CF, Rosenthal EL, Morgan BA, McColloch NL, Magnuson JS
Dynasplint for the management of trismus after treatment of upper aerodigestive tract cancer: a retrospective study. Ear Nose Throat J. 2011 Dec; 90(12):584-90.
Dynasplint for the management of trismus after treatment of upper aerodigestive tract cancer: a retrospective study.
Yoshida T, Landhuis E, Dose M, Hazan I, Zhang J, Naito T, Jackson AF, Wu J, Perotti EA, Kaufmann C, Gounari F, Morgan BA, Georgopoulos K
Transcriptional regulation of the Ikzf1 locus. Blood. 2013 Oct 31; 122(18):3149-59.
Transcriptional regulation of the Ikzf1 locus.
The "skinny" on Wnt signaling in stem cells. Cell Stem Cell. 2013 Dec 05; 13(6):638-40.
The "skinny" on Wnt signaling in stem cells.
Dean NR, Rosenthal EL, Morgan BA, Magnuson JS, Carroll WR
Harmonic Scalpel versus electrocautery and surgical clips in head and neck free-flap harvesting. Ear Nose Throat J. 2014 Jun; 93(6):E36-9.
Harmonic Scalpel versus electrocautery and surgical clips in head and neck free-flap harvesting.
Schwarzländer M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, Johnston IG, Jones NS, Logan DC, Morgan B, Müller FL, Nicholls DG, Remington SJ, Schumacker PT, Winterbourn CC, Sweetlove LJ, Meyer AJ, Dick TP, Murphy MP
The 'mitoflash' probe cpYFP does not respond to superoxide. Nature. 2014 Oct 23; 514(7523):E12-4.
The 'mitoflash' probe cpYFP does not respond to superoxide.
Yap YW, Rusu PM, Chan AY, Fam BC, Jungmann A, Solon-Biet SM, Barlow CK, Creek DJ, Huang C, Schittenhelm RB, Morgan B, Schmoll D, Kiens B, Piper MDW, Heikenwälder M, Simpson SJ, Bröer S, Andrikopoulos S, Müller OJ, Rose AJ
Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution. Nat Commun. 2020 06 09; 11(1):2894.
Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution.
Cold Spring Harbor perspectives in medicine
The dermal papilla: an instructive niche for epithelial stem and progenitor cells in development and regeneration of the hair follicle. Cold Spring Harb Perspect Med. 2014 Jul 01; 4(7):a015180.
The dermal papilla: an instructive niche for epithelial stem and progenitor cells in development and regeneration of the hair follicle.
Earlier-born secondary hair follicles exhibit phenotypic plasticity. Exp Dermatol. 2015 Apr; 24(4):265-8.
Earlier-born secondary hair follicles exhibit phenotypic plasticity.
Rieder SA, Metidji A, Glass DD, Thornton AM, Ikeda T, Morgan BA, Shevach EM
Journal of immunology (Baltimore, Md. : 1950)
Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells. J Immunol. 2015 Jul 15; 195(2):553-63.
Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells.
Buck V, Quinn J, Soto Pino T, Martin H, Saldanha J, Makino K, Morgan BA, Millar JB
Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway. Mol Biol Cell. 2001 Feb; 12(2):407-19.
Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway.
Kamberov YG, Karlsson EK, Kamberova GL, Lieberman DE, Sabeti PC, Morgan BA, Tabin CJ
A genetic basis of variation in eccrine sweat gland and hair follicle density. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):9932-7.
A genetic basis of variation in eccrine sweat gland and hair follicle density.
Merrill GF, Morgan BA, Lowndes NF, Johnston LH
BioEssays : news and reviews in molecular, cellular and developmental biology
DNA synthesis control in yeast: an evolutionarily conserved mechanism for regulating DNA synthesis genes? Bioessays. 1992 Dec; 14(12):823-30.
DNA synthesis control in yeast: an evolutionarily conserved mechanism for regulating DNA synthesis genes?
Gómez-Del Arco P, Perdiguero E, Yunes-Leites PS, Acín-Pérez R, Zeini M, Garcia-Gomez A, Sreenivasan K, Jiménez-Alcázar M, Segalés J, López-Maderuelo D, Ornés B, Jiménez-Borreguero LJ, D'Amato G, Enshell-Seijffers D, Morgan B, Georgopoulos K, Islam AB, Braun T, de la Pompa JL, Kim J, Enriquez JA, Ballestar E, Muñoz-Cánoves P, Redondo JM
The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis. Cell Metab. 2016 May 10; 23(5):881-92.
The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis.
Function of Engrailed-1 in eccrine gland development
BETA CATENIN SIGNALING DURING FEATHER TRACT DEVELOPMENT
PATTERN FORMATION: THE PROXIMAL/DISTAL AXIS OF THE LIMB
Inductive properties of the dermal papilla of the hair follicle
The Helios Gene in Development and Homeostasis of Skin
The Journal of investigative dermatology
Stabilization of ß-Catenin Does Not Increase Dermal Papilla Cell Number in the Hair Follicle. J Invest Dermatol. 2017 01; 137(1):245-246.
Stabilization of ß-Catenin Does Not Increase Dermal Papilla Cell Number in the Hair Follicle.
Kashiwagi M, Hosoi J, Lai JF, Brissette J, Ziegler SF, Morgan BA, Georgopoulos K
Direct control of regulatory T cells by keratinocytes. Nat Immunol. 2017 03; 18(3):334-343.
Direct control of regulatory T cells by keratinocytes.
Wnt signaling maintains the hair-inducing activity of the dermal papilla. Genes Dev. 2000 May 15; 14(10):1181-5.
Wnt signaling maintains the hair-inducing activity of the dermal papilla.
Toone WM, Kuge S, Samuels M, Morgan BA, Toda T, Jones N
Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1. Genes Dev. 1998 May 15; 12(10):1453-63.
Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1.
beta-catenin signaling can initiate feather bud development. Development. 1999 Aug; 126(16):3509-21.
beta-catenin signaling can initiate feather bud development.
Swain L, Kesemeyer A, Meyer-Roxlau S, Vettel C, Zieseniss A, Güntsch A, Jatho A, Becker A, Nanadikar MS, Morgan B, Dennerlein S, Shah AM, El-Armouche A, Nikolaev VO, Katschinski DM
Redox Imaging Using Cardiac Myocyte-Specific Transgenic Biosensor Mice. Circ Res. 2016 Oct 14; 119(9):1004-1016.
Redox Imaging Using Cardiac Myocyte-Specific Transgenic Biosensor Mice.
Dohrmann CE, Noramly S, Raftery LA, Morgan BA
Developmental dynamics : an official publication of the American Association of Anatomists
Opposing effects on TSC-22 expression by BMP and receptor tyrosine kinase signals in the developing feather tract. Dev Dyn. 2002 Jan; 223(1):85-95.
Opposing effects on TSC-22 expression by BMP and receptor tyrosine kinase signals in the developing feather tract.
Morgan BA, Banks GR, Toone WM, Raitt D, Kuge S, Johnston LH
The Skn7 response regulator controls gene expression in the oxidative stress response of the budding yeast Saccharomyces cerevisiae. EMBO J. 1997 Mar 03; 16(5):1035-44.
The Skn7 response regulator controls gene expression in the oxidative stress response of the budding yeast Saccharomyces cerevisiae.
Wnt signaling through the beta-catenin pathway is sufficient to maintain, but not restore, anagen-phase characteristics of dermal papilla cells. J Invest Dermatol. 2004 Feb; 122(2):239-45.
Wnt signaling through the beta-catenin pathway is sufficient to maintain, but not restore, anagen-phase characteristics of dermal papilla cells.
The highly conserved N-terminal domains of histones H3 and H4 are required for normal cell cycle progression. Mol Cell Biol. 1991 Aug; 11(8):4111-20.
The highly conserved N-terminal domains of histones H3 and H4 are required for normal cell cycle progression.
Wang JH, Avitahl N, Cariappa A, Friedrich C, Ikeda T, Renold A, Andrikopoulos K, Liang L, Pillai S, Morgan BA, Georgopoulos K
Aiolos regulates B cell activation and maturation to effector state. Immunity. 1998 Oct; 9(4):543-53.
Aiolos regulates B cell activation and maturation to effector state.
Pic A, Lim FL, Ross SJ, Veal EA, Johnson AL, Sultan MR, West AG, Johnston LH, Sharrocks AD, Morgan BA
The forkhead protein Fkh2 is a component of the yeast cell cycle transcription factor SFF. EMBO J. 2000 Jul 17; 19(14):3750-61.
The forkhead protein Fkh2 is a component of the yeast cell cycle transcription factor SFF.
Developmental biology: a hair-raising tale. Nature. 2011 Mar 31; 471(7340):586-7.
Developmental biology: a hair-raising tale.
Roberts DJ, Johnson RL, Burke AC, Nelson CE, Morgan BA, Tabin C
Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut. Development. 1995 Oct; 121(10):3163-74.
Sonic hedgehog is an endodermal signal inducing Bmp-4 and Hox genes during induction and regionalization of the chick hindgut.
Morgan BA, Izpisúa-Belmonte JC, Duboule D, Tabin CJ
Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations. Nature. 1992 Jul 16; 358(6383):236-9.
Targeted misexpression of Hox-4.6 in the avian limb bud causes apparent homeotic transformations.
De novo production of dermal papilla cells during the anagen phase of the hair cycle. J Invest Dermatol. 2010 Nov; 130(11):2664-6.
De novo production of dermal papilla cells during the anagen phase of the hair cycle.
Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K
Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J. 1997 Apr 15; 16(8):2004-13.
Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation.
Scholnick SB, Bray SJ, Morgan BA, McCormick CA, Hirsh J
CNS and hypoderm regulatory elements of the Drosophila melanogaster dopa decarboxylase gene. Science. 1986 Nov 21; 234(4779):998-1002.
CNS and hypoderm regulatory elements of the Drosophila melanogaster dopa decarboxylase gene.
Aiolos, Helios, Daedalos and Ikaros: genes, polypeptides, regulatory elements and uses thereof
Aiolos, Helios, Daedalos and Ikaros: genes, polypeptides, regulatory elements and uses thereof. 2007.
Morgan BA, Conlon FL, Manzanares M, Millar JB, Kanuga N, Sharpe J, Krumlauf R, Smith JC, Sedgwick SG
Transposon tools for recombinant DNA manipulation: characterization of transcriptional regulators from yeast, Xenopus, and mouse. Proc Natl Acad Sci U S A. 1996 Apr 02; 93(7):2801-6.
Transposon tools for recombinant DNA manipulation: characterization of transcriptional regulators from yeast, Xenopus, and mouse.
The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny. Development. 2007 Apr; 134(8):1571-82.
The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny.
Houghton L, Lindon CM, Freeman A, Morgan BA
Abortive placode formation in the feather tract of the scaleless chicken embryo. Dev Dyn. 2007 Nov; 236(11):3020-30.
Abortive placode formation in the feather tract of the scaleless chicken embryo.
Regulated splicing produces different forms of dopa decarboxylase in the central nervous system and hypoderm of Drosophila melanogaster. EMBO J. 1986 Dec 01; 5(12):3335-42.
Regulated splicing produces different forms of dopa decarboxylase in the central nervous system and hypoderm of Drosophila melanogaster.
A glorious revolution in stem cell biology. Nat Genet. 2008 Nov; 40(11):1269-70.
A glorious revolution in stem cell biology.
The cloned dopa decarboxylase gene is developmentally regulated when reintegrated into the Drosophila genome. Cell. 1983 Aug; 34(1):37-45.
The cloned dopa decarboxylase gene is developmentally regulated when reintegrated into the Drosophila genome.
Hox genes in embryonic development. J. Poultry Sci. 1997; 76:96-104.
Enshell-Seijffers D, Lindon C, Morgan BA
The serine protease Corin is a novel modifier of the Agouti pathway. Development. 2008 Jan; 135(2):217-25.
The serine protease Corin is a novel modifier of the Agouti pathway.
Simon HG, Nelson C, Goff D, Laufer E, Morgan BA, Tabin C
Differential expression of myogenic regulatory genes and Msx-1 during dedifferentiation and redifferentiation of regenerating amphibian limbs. Dev Dyn. 1995 Jan; 202(1):1-12.
Differential expression of myogenic regulatory genes and Msx-1 during dedifferentiation and redifferentiation of regenerating amphibian limbs.
Hox genes and embryonic development. Poult Sci. 1997 Jan; 76(1):96-104.
Kelley CM, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K, Morgan BA
Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. Curr Biol. 1998 Apr 23; 8(9):508-15.
Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors.
Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline. Development. 2013 Apr; 140(8):1676-83.
Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline.
Expression and regulation of Groucho-related genes in the embryonic chicken feather bud. Dev Dyn. 2003 Apr; 226(4):587-95.
Expression and regulation of Groucho-related genes in the embryonic chicken feather bud.