JAM4JMartynJ A Jeevendra Martyn, M.B.,B.S.42.36241700000000-71.068937000000009400Martyn, JA Jeevendra617/726-8807Professor of Anaesthesiacatalyst:eCommonsLogineCommons Loginprns:coAuthorOfcoauthor ofFaculty Rankprns:fullNamefull nameprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:address2address line 2vivo:address3address line 3vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provincevivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionvivo:hasResearchArearesearch areasvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:middleNamemiddle name or initialvivo:personInPositionpositionsvivo:phoneNumberphonePositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titlerdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson10736074Soriano SG, Kaus SJ, Sullivan LJ, Martyn JAPaediatric anaesthesiaOnset and duration of action of rocuronium in children receiving chronic anticonvulsant therapy. Paediatr Anaesth. 2000; 10(2):133-6.Paediatr Anaesth2000-01-01T00:00:002000Onset and duration of action of rocuronium in children receiving chronic anticonvulsant therapy.Authorship 10488161028747716Nakazawa H, Ikeda K, Shinozaki S, Kobayashi M, Ikegami Y, Fu M, Nakamura T, Yasuhara S, Yu YM, Martyn JAJ, Tompkins RG, Shimokado K, Yorozu T, Ito H, Inoue S, Kaneki MScientific reportsBurn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1a and mTORC1: Role of protein farnesylation. Sci Rep. 2017 07 26; 7(1):6618.Sci Rep2017-07-26T00:00:002017Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1a and mTORC1: Role of protein farnesylation.11049916Ibebunjo C, Martyn JAAnesthesia and analgesiaThermal injury induces greater resistance to d-tubocurarine in local rather than in distant muscles in the rat. Anesth Analg. 2000 Nov; 91(5):1243-9.Anesth Analg2000-11-01T00:00:002000Thermal injury induces greater resistance to d-tubocurarine in local rather than in distant muscles in the rat.11573664Soriano SG, Sullivan LJ, Venkatakrishnan K, Greenblatt DJ, Martyn JABritish journal of anaesthesiaPharmacokinetics and pharmacodynamics of vecuronium in children receiving phenytoin or carbamazepine for chronic anticonvulsant therapy. Br J Anaesth. 2001 Feb; 86(2):223-9.Br J Anaesth2001-02-01T00:00:002001Pharmacokinetics and pharmacodynamics of vecuronium in children receiving phenytoin or carbamazepine for chronic anticonvulsant therapy.3355741Mills AK, Martyn JABritish journal of anaesthesiaEvaluation of atracurium neuromuscular blockade in paediatric patients with burn injury. Br J Anaesth. 1988 Mar; 60(4):450-5.Br J Anaesth1988-03-01T00:00:001988Evaluation of atracurium neuromuscular blockade in paediatric patients with burn injury.7760531Martyn JAThe Keio journal of medicineBasic and clinical pharmacology of the acetylcholine receptor: implications for the use of neuromuscular relaxants. Keio J Med. 1995 Mar; 44(1):1-8.Keio J Med1995-03-01T00:00:001995Basic and clinical pharmacology of the acetylcholine receptor: implications for the use of neuromuscular relaxants.3344995Kim C, Fuke N, Martyn JAAnesthesiologyBurn injury to rat increases nicotinic acetylcholine receptors in the diaphragm. Anesthesiology. 1988 Mar; 68(3):401-6.Anesthesiology1988-03-01T00:00:001988Burn injury to rat increases nicotinic acetylcholine receptors in the diaphragm.3647042Martyn JAThe Journal of burn care & rehabilitationBurn care protocols: administration of ketamine. Ketamine pharmacology and therapeutics. J Burn Care Rehabil. 1987 Mar-Apr; 8(2):146-8.J Burn Care Rehabil1987-03-01T00:00:001987Burn care protocols: administration of ketamine. Ketamine pharmacology and therapeutics.3965241Martyn JACritical care medicineCimetidine and/or antacid for the control of gastric acidity in pediatric burn patients. Crit Care Med. 1985 Jan; 13(1):1-3.Crit Care Med1985-01-01T00:00:001985Cimetidine and/or antacid for the control of gastric acidity in pediatric burn patients.8665854Ikezu T, Okamoto T, Komatsuzaki K, Matsui T, Martyn JA, Nishimoto IThe EMBO journalNegative transactivation of cAMP response element by familial Alzheimer's mutants of APP. EMBO J. 1996 May 15; 15(10):2468-75.EMBO J1996-05-15T00:00:001996Negative transactivation of cAMP response element by familial Alzheimer's mutants of APP.2556207Tomera JF, Martyn JBritish journal of pharmacologyMediators of burn-induced neuromuscular changes in mice. Br J Pharmacol. 1989 Nov; 98(3):921-9.Br J Pharmacol1989-11-01T00:00:001989Mediators of burn-induced neuromuscular changes in mice.3948549Martyn J, Wilson RS, Burke JFChestRight ventricular function and pulmonary hemodynamics during dopamine infusion in burned patients. Chest. 1986 Mar; 89(3):357-60.Chest1986-03-01T00:00:001986Right ventricular function and pulmonary hemodynamics during dopamine infusion in burned patients.2737228Martyn JA, Greenblatt DJ, Hagen J, Hoaglin DCEuropean journal of clinical pharmacologyAlteration by burn injury of the pharmacokinetics and pharmacodynamics of cimetidine in children. Eur J Clin Pharmacol. 1989; 36(4):361-7.Eur J Clin Pharmacol1989-01-01T00:00:001989Alteration by burn injury of the pharmacokinetics and pharmacodynamics of cimetidine in children.Authorship 10612442947935Martyn J, Goldhill DR, Goudsouzian NGJournal of clinical pharmacologyClinical pharmacology of muscle relaxants in patients with burns. J Clin Pharmacol. 1986 Nov-Dec; 26(8):680-5.J Clin Pharmacol1986-11-01T00:00:001986Clinical pharmacology of muscle relaxants in patients with burns.Authorship 104876123274498Yasuda Y, Fukushima Y, Kaneki M, Martyn JABiochemical and biophysical research communicationsAnesthesia with propofol induces insulin resistance systemically in skeletal and cardiac muscles and liver of rats. Biochem Biophys Res Commun. 2013 Feb 01; 431(1):81-5.Biochem Biophys Res Commun2012-12-28T00:00:002012Anesthesia with propofol induces insulin resistance systemically in skeletal and cardiac muscles and liver of rats.15855318Fujimoto M, Shimizu N, Kunii K, Martyn JA, Ueki K, Kaneki MDiabetesA role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice. Diabetes. 2005 May; 54(5):1340-8.Diabetes2005-05-01T00:00:002005A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice.1968351Baker TR, Vouros P, Rindgen D, Martyn JABiomedical & environmental mass spectrometryMass spectrometric assay for determination of pancuronium and vecuronium in biological fluids utilizing the moving belt introduction system. Biomed Environ Mass Spectrom. 1990 Feb; 19(2):69-74.Biomed Environ Mass Spectrom1990-02-01T00:00:001990Mass spectrometric assay for determination of pancuronium and vecuronium in biological fluids utilizing the moving belt introduction system.2175230Tomera JF, Martyn JABritish journal of pharmacologyThermal trauma alters myocardial cyclic nucleotides and protein content in mice. Br J Pharmacol. 1990 Oct; 101(2):263-8.Br J Pharmacol1990-10-01T00:00:001990Thermal trauma alters myocardial cyclic nucleotides and protein content in mice.1592722Hogue CW, Ward JM, Itani MS, Martyn JAJournal of applied physiology (Bethesda, Md. : 1985)Tolerance and upregulation of acetylcholine receptors follow chronic infusion of d-tubocurarine. J Appl Physiol (1985). 1992 Apr; 72(4):1326-31.J Appl Physiol (1985)1992-04-01T00:00:001992Tolerance and upregulation of acetylcholine receptors follow chronic infusion of d-tubocurarine.8602670Yanez P, Martyn JAAnesthesiologyProlonged d-tubocurarine infusion and/or immobilization cause upregulation of acetylcholine receptors and hyperkalemia to succinylcholine in rats. Anesthesiology. 1996 Feb; 84(2):384-91.Anesthesiology1996-02-01T00:00:001996Prolonged d-tubocurarine infusion and/or immobilization cause upregulation of acetylcholine receptors and hyperkalemia to succinylcholine in rats.2968490Storella RJ, Martyn JA, Bierkamper GGLife sciencesAnti-curare effect of plasma from patients with thermal injury. Life Sci. 1988; 43(1):35-40.Life Sci1988-01-01T00:00:001988Anti-curare effect of plasma from patients with thermal injury.1889571Ward JM, Martyn JBiochemical Society transactionsAlterations in neuromuscular function following thermal injury. Biochem Soc Trans. 1991 Apr; 19(2):191S.Biochem Soc Trans1991-04-01T00:00:001991Alterations in neuromuscular function following thermal injury.16126910Astrakas LG, Goljer I, Yasuhara S, Padfield KE, Zhang Q, Gopalan S, Mindrinos MN, Dai G, Yu YM, Martyn JA, Tompkins RG, Rahme LG, Tzika AAFASEB journal : official publication of the Federation of American Societies for Experimental BiologyProton NMR spectroscopy shows lipids accumulate in skeletal muscle in response to burn trauma-induced apoptosis. FASEB J. 2005 Sep; 19(11):1431-40.FASEB J2005-09-01T00:00:002005Proton NMR spectroscopy shows lipids accumulate in skeletal muscle in response to burn trauma-induced apoptosis.2883985Goldhill DR, Martyn JA, Hoaglin DCBritish journal of anaesthesiaBeta-adrenoceptor blockade, alpha-stimulation and changes in plasma potassium concentration after suxamethonium administration in dogs. Br J Anaesth. 1987 May; 59(5):611-6.Br J Anaesth1987-05-01T00:00:001987Beta-adrenoceptor blockade, alpha-stimulation and changes in plasma potassium concentration after suxamethonium administration in dogs.3345616Martyn J, Greenblatt DJClinical pharmacology and therapeuticsLorazepam conjugation is unimpaired in burn trauma. Clin Pharmacol Ther. 1988 Mar; 43(3):250-5.Clin Pharmacol Ther1988-03-01T00:00:001988Lorazepam conjugation is unimpaired in burn trauma.6316813Martyn JA, Liu LM, Szyfelbein SK, Ambalavanar ES, Goudsouzian NGAnesthesiologyThe neuromuscular effects of pancuronium in burned children. Anesthesiology. 1983 Dec; 59(6):561-4.Anesthesiology1983-12-01T00:00:001983The neuromuscular effects of pancuronium in burned children.7631953Kim C, Hirose M, Martyn JAAnesthesiologyd-Tubocurarine accentuates the burn-induced upregulation of nicotinic acetylcholine receptors at the muscle membrane. Anesthesiology. 1995 Aug; 83(2):309-15.Anesthesiology1995-08-01T00:00:001995d-Tubocurarine accentuates the burn-induced upregulation of nicotinic acetylcholine receptors at the muscle membrane.19029093Han TH, Martyn JABritish journal of anaesthesiaOnset and effectiveness of rocuronium for rapid onset of paralysis in patients with major burns: priming or large bolus. Br J Anaesth. 2009 Jan; 102(1):55-60.Br J Anaesth2008-11-21T00:00:002008Onset and effectiveness of rocuronium for rapid onset of paralysis in patients with major burns: priming or large bolus.18979014Asai A, Sahani N, Ouchi Y, Martyn J, Yasuhara SJournal of visualized experiments : JoVEIn vivo micro-circulation measurement in skeletal muscle by intra-vital microscopy. J Vis Exp. 2007; (4):210.J Vis Exp2007-05-28T00:00:002007In vivo micro-circulation measurement in skeletal muscle by intra-vital microscopy.20009758Frick CG, Helming M, Martyn JA, Blobner M, Fink HCritical care medicineContinuous administration of pyridostigmine improves immobilization-induced neuromuscular weakness. Crit Care Med. 2010 Mar; 38(3):922-7.Crit Care Med2010-03-01T00:00:002010Continuous administration of pyridostigmine improves immobilization-induced neuromuscular weakness.6212001Martyn JA, Matteo RS, Szyfelbein SK, Kaplan RFAnesthesia and analgesiaUnprecedented resistance to neuromuscular blocking effects of metocurine with persistence after complete recovery in a burned patient. Anesth Analg. 1982 Jul; 61(7):614-7.Anesth Analg1982-07-01T00:00:001982Unprecedented resistance to neuromuscular blocking effects of metocurine with persistence after complete recovery in a burned patient.Authorship 12735662887128Goldhill DR, Martyn JAAnaesthesiaBeta blockade, suxamethonium and potassium. Anaesthesia. 1987 Jun; 42(6):670-1.Anaesthesia1987-06-01T00:00:001987Beta blockade, suxamethonium and potassium.2570602Mills AK, Martyn JABritish journal of clinical pharmacologyNeuromuscular blockade with vecuronium in paediatric patients with burn injury. Br J Clin Pharmacol. 1989 Aug; 28(2):155-9.Br J Clin Pharmacol1989-08-01T00:00:001989Neuromuscular blockade with vecuronium in paediatric patients with burn injury.21354998Han TH, Martyn JABritish journal of anaesthesiaNeuromuscular pharmacodynamics of mivacurium in adults with major burns. Br J Anaesth. 2011 May; 106(5):675-9.Br J Anaesth2011-02-24T00:00:002011Neuromuscular pharmacodynamics of mivacurium in adults with major burns.3777466Hagen J, Martyn J, Szyfelbein SK, Goudsouzian NGAnesthesia and analgesiaCardiovascular and neuromuscular responses to high-dose pancuronium-metocurine in pediatric burned and reconstructive patients. Anesth Analg. 1986 Dec; 65(12):1340-4.Anesth Analg1986-12-01T00:00:001986Cardiovascular and neuromuscular responses to high-dose pancuronium-metocurine in pediatric burned and reconstructive patients.22995863Kaneki M, Fukushima Y, Shinozaki S, Fukaya M, Habiro M, Shimizu N, Chang K, Yasuhara S, Martyn JAMetabolism: clinical and experimentaliNOS inhibitor, L-NIL, reverses burn-induced glycogen synthase kinase-3ß activation in skeletal muscle of rats. Metabolism. 2013 Mar; 62(3):341-6.Metabolism2012-09-17T00:00:002012iNOS inhibitor, L-NIL, reverses burn-induced glycogen synthase kinase-3ß activation in skeletal muscle of rats.3036758Fuke N, Martyn J, Kim CS, Basta SJournal of applied physiology (Bethesda, Md. : 1985)Concentration-dependent interaction of theophylline with d-tubocurarine. J Appl Physiol (1985). 1987 May; 62(5):1970-4.J Appl Physiol (1985)1987-05-01T00:00:001987Concentration-dependent interaction of theophylline with d-tubocurarine.3753829Goudsouzian N, Martyn J, Rudd GD, Liu LM, Lineberry CGAnesthesiologyContinuous infusion of atracurium in children. Anesthesiology. 1986 Feb; 64(2):171-4.Anesthesiology1986-02-01T00:00:001986Continuous infusion of atracurium in children.6829917Martyn JA, Leibel WS, Matteo RSAnesthesia and analgesiaCompetitive nonspecific binding does not explain the potentiating effects of muscle relaxant combinations. Anesth Analg. 1983 Feb; 62(2):160-3.Anesth Analg1983-02-01T00:00:001983Competitive nonspecific binding does not explain the potentiating effects of muscle relaxant combinations.15632167Yasukawa T, Tokunaga E, Ota H, Sugita H, Martyn JA, Kaneki MThe Journal of biological chemistryS-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance. J Biol Chem. 2005 Mar 04; 280(9):7511-8.J Biol Chem2005-01-04T00:00:002005S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance.Authorship 124149317428913Han T, Harmatz JS, Greenblatt DJ, Martyn JAJournal of clinical pharmacologyFentanyl clearance and volume of distribution are increased in patients with major burns. J Clin Pharmacol. 2007 Jun; 47(6):674-80.J Clin Pharmacol2007-04-11T00:00:002007Fentanyl clearance and volume of distribution are increased in patients with major burns.17952407Frick CG, Fink H, Gordan ML, Eckel B, Martyn JA, Blobner MIntensive care medicineChronic Escherichia coli infection induces muscle wasting without changing acetylcholine receptor numbers. Intensive Care Med. 2008 Mar; 34(3):561-7.Intensive Care Med2007-10-20T00:00:002007Chronic Escherichia coli infection induces muscle wasting without changing acetylcholine receptor numbers.477418Martyn JA, Burke JFChestIs there a selective increase in pulmonary capillary permeability following cutaneous burns? Chest. 1979 Oct; 76(4):374-5.Chest1979-10-01T00:00:001979Is there a selective increase in pulmonary capillary permeability following cutaneous burns?3592192Martyn JA, Goldhill DRAnaesthesiaCold injury and hyperkalaemia. Anaesthesia. 1987 May; 42(5):561.Anaesthesia1987-05-01T00:00:001987Cold injury and hyperkalaemia.7224206Leibel WS, Martyn JA, Szyfelbein SK, Miller KWAnesthesiologyElevated plasma binding cannot account for the burn-related d-tubocurarine hyposensitivity. Anesthesiology. 1981 May; 54(5):378-82.Anesthesiology1981-05-01T00:00:001981Elevated plasma binding cannot account for the burn-related d-tubocurarine hyposensitivity.8699148Oldham JM, Martyn JA, Kirk SP, Napier JR, Bass JJThe Journal of endocrinologyRegulation of type 1 insulin-like growth factor (IGF) receptors and IGF-I mRNA by age and nutrition in ovine skeletal muscles. J Endocrinol. 1996 Feb; 148(2):337-46.J Endocrinol1996-02-01T00:00:001996Regulation of type 1 insulin-like growth factor (IGF) receptors and IGF-I mRNA by age and nutrition in ovine skeletal muscles.22683726Khan MA, Farkhondeh M, Crombie J, Jacobson L, Kaneki M, Martyn JAShock (Augusta, Ga.)Lipopolysaccharide upregulates a7 acetylcholine receptors: stimulation with GTS-21 mitigates growth arrest of macrophages and improves survival in burned mice. Shock. 2012 Aug; 38(2):213-9.Shock2012-08-01T00:00:002012Lipopolysaccharide upregulates a7 acetylcholine receptors: stimulation with GTS-21 mitigates growth arrest of macrophages and improves survival in burned mice.3354895Glidden RS, Martyn JA, Tomera JFAnesthesiologyAzathioprine fails to alter the dose-response curve of d-tubocurarine in rats. Anesthesiology. 1988 Apr; 68(4):595-8.Anesthesiology1988-04-01T00:00:001988Azathioprine fails to alter the dose-response curve of d-tubocurarine in rats.665908Aikawa N, Martyn JA, Burke JFAmerican journal of surgeryPulmonary artery catheterization and thermodilution cardiac output determination in the management of critically burned patients. Am J Surg. 1978 Jun; 135(6):811-7.Am J Surg1978-06-01T00:00:001978Pulmonary artery catheterization and thermodilution cardiac output determination in the management of critically burned patients.7373676Morgan RJ, Martyn JA, Philbin DM, Coggins CH, Burke JFThe Journal of traumaWater metabolism and antidiuretic hormone (ADH) response following thermal injury. J Trauma. 1980 Jun; 20(6):468-72.J Trauma1980-06-01T00:00:001980Water metabolism and antidiuretic hormone (ADH) response following thermal injury.10613683Yasuhara S, Kanakubo E, Perez ME, Kaneki M, Fujita T, Okamoto T, Martyn JAThe Journal of burn care & rehabilitationThe 1999 Moyer award. Burn injury induces skeletal muscle apoptosis and the activation of caspase pathways in rats. J Burn Care Rehabil. 1999 Nov-Dec; 20(6):462-70.J Burn Care Rehabil1999-11-01T00:00:001999The 1999 Moyer award. Burn injury induces skeletal muscle apoptosis and the activation of caspase pathways in rats.487845Martyn JA, Aikawa N, Wilson RS, Szyfelbein SK, Burke JFCritical care medicineExtrapulmonary factors influencing the ratio of arterial oxygen tension to inspired oxygen concentration in burn patients. Crit Care Med. 1979 Nov; 7(11):492-6.Crit Care Med1979-11-01T00:00:001979Extrapulmonary factors influencing the ratio of arterial oxygen tension to inspired oxygen concentration in burn patients.12544419Lydon A, Martyn JAInternational anesthesiology clinicsApoptosis in critical illness. Int Anesthesiol Clin. 2003; 41(1):65-77.Int Anesthesiol Clin2003-01-01T00:00:002003Apoptosis in critical illness.7199837Martyn JA, Matteo RS, Greenblatt DJ, Lebowitz PW, Savarese JJAnesthesia and analgesiaPharmacokinetics of d-tubocurarine in patients with thermal injury. Anesth Analg. 1982 Mar; 61(3):241-6.Anesth Analg1982-03-01T00:00:001982Pharmacokinetics of d-tubocurarine in patients with thermal injury.6705453Martyn JA, Abernethy DR, Greenblatt DJClinical pharmacology and therapeuticsPlasma protein binding of drugs after severe burn injury. Clin Pharmacol Ther. 1984 Apr; 35(4):535-9.Clin Pharmacol Ther1984-04-01T00:00:001984Plasma protein binding of drugs after severe burn injury.2545858Tomera JF, Martyn JThe Journal of pharmacology and experimental therapeuticsIntraperitoneal endotoxin but not protein malnutrition shifts d-tubocurarine dose-response curves in mouse gastrocnemius muscle. J Pharmacol Exp Ther. 1989 Jul; 250(1):216-20.J Pharmacol Exp Ther1989-07-01T00:00:001989Intraperitoneal endotoxin but not protein malnutrition shifts d-tubocurarine dose-response curves in mouse gastrocnemius muscle.Authorship 10920426402956Martyn JA, Greenblatt DJ, Quinby WCAnesthesia and analgesiaDiazepam kinetics in patients with severe burns. Anesth Analg. 1983 Mar; 62(3):293-7.Anesth Analg1983-03-01T00:00:001983Diazepam kinetics in patients with severe burns.7201758Lebowitz PW, Cote ME, Daniels AL, Ramsey FM, Martyn JA, Teplick RS, Davison JKAnesthesia and analgesiaComparative cardiovascular effects of midazolam and thiopental in healthy patients. Anesth Analg. 1982 Sep; 61(9):771-5.Anesth Analg1982-09-01T00:00:001982Comparative cardiovascular effects of midazolam and thiopental in healthy patients.8408164Tomera JF, Lilford K, Martyn JAThe Journal of burn care & rehabilitationDiaphragm acetylcholinesterase multimeric forms in mice in response to burn trauma. J Burn Care Rehabil. 1993 Jul-Aug; 14(4):406-19.J Burn Care Rehabil1993-07-01T00:00:001993Diaphragm acetylcholinesterase multimeric forms in mice in response to burn trauma.1563210Martyn JA, Bishop AL, Oliveri MFClinical pharmacology and therapeuticsPharmacokinetics and pharmacodynamics of ranitidine after burn injury. Clin Pharmacol Ther. 1992 Apr; 51(4):408-14.Clin Pharmacol Ther1992-04-01T00:00:001992Pharmacokinetics and pharmacodynamics of ranitidine after burn injury.12502983Fink H, Luppa P, Mayer B, Rosenbrock H, Metzger J, Martyn JA, Blobner MAnesthesiologySystemic inflammation leads to resistance to atracurium without increasing membrane expression of acetylcholine receptors. Anesthesiology. 2003 Jan; 98(1):82-8.Anesthesiology2003-01-01T00:00:002003Systemic inflammation leads to resistance to atracurium without increasing membrane expression of acetylcholine receptors.17726536Asai A, Sahani N, Kaneki M, Ouchi Y, Martyn JA, Yasuhara SEPloS onePrimary role of functional ischemia, quantitative evidence for the two-hit mechanism, and phosphodiesterase-5 inhibitor therapy in mouse muscular dystrophy. PLoS One. 2007 Aug 29; 2(8):e806.PLoS One2007-08-29T00:00:002007Primary role of functional ischemia, quantitative evidence for the two-hit mechanism, and phosphodiesterase-5 inhibitor therapy in mouse muscular dystrophy.19533664Ginsburg G, Forde R, Martyn JA, Eikermann MMuscle & nerveIncreased sensitivity to a nondepolarizing muscle relaxant in a patient with acquired neuromyotonia. Muscle Nerve. 2009 Jul; 40(1):139-42.Muscle Nerve2009-07-01T00:00:002009Increased sensitivity to a nondepolarizing muscle relaxant in a patient with acquired neuromyotonia.Authorship 1128264130673555Martyn JAJ, Mao J, Bittner EAThe New England journal of medicineOpioid Tolerance in Critical Illness. N Engl J Med. 2019 01 24; 380(4):365-378.N Engl J Med2019-01-24T00:00:002019Opioid Tolerance in Critical Illness.Authorship 1129552530702509Ma L, Zhou Y, Khan MAS, Yasuhara S, Martyn JAJShock (Augusta, Ga.)Burn-Induced Microglia Activation is Associated With Motor Neuron Degeneration and Muscle Wasting in Mice. Shock. 2019 05; 51(5):569-579.Shock2019-05-01T00:00:002019Burn-Induced Microglia Activation is Associated With Motor Neuron Degeneration and Muscle Wasting in Mice.6326786Satwicz PR, Martyn JA, Szyfelbein SK, Firestone SBritish journal of anaesthesiaPotentiation of neuromuscular blockade using a combination of pancuronium and dimethyltubocurarine. Studies in children following acute burn injury or during reconstructive surgery. Br J Anaesth. 1984 May; 56(5):479-84.Br J Anaesth1984-05-01T00:00:001984Potentiation of neuromuscular blockade using a combination of pancuronium and dimethyltubocurarine. Studies in children following acute burn injury or during reconstructive surgery.30793320Nozari A, Akeju O, Mirzakhani H, Eskandar E, Ma Z, Hossain MA, Wang Q, Greenblatt DJ, Martyn JAJThe Journal of pharmacy and pharmacologyProlonged therapy with the anticonvulsant carbamazepine leads to increased plasma clearance of fentanyl. J Pharm Pharmacol. 2019 Jun; 71(6):982-987.J Pharm Pharmacol2019-02-21T00:00:002019Prolonged therapy with the anticonvulsant carbamazepine leads to increased plasma clearance of fentanyl.Authorship 1132634630761259Nakazawa H, Ikeda K, Shinozaki S, Yasuhara S, Yu YM, Martyn JAJ, Tompkins RG, Yorozu T, Inoue S, Kaneki MFEBS open bioCoenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle. FEBS Open Bio. 2019 02; 9(2):348-363.FEBS Open Bio2019-01-19T00:00:002019Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle.Authorship 11366269D003473Chemicals & Drugs751470.897274Neuromuscular Nondepolarizing AgentsD011950Chemicals & Drugs1052380.899821Receptors, CholinergicAuthorship 1144906130995390Martyn JAJ, Mao J, Bittner EAThe New England journal of medicineOpioid Tolerance in Critical Illness. Reply. N Engl J Med. 2019 04 18; 380(16):e26.N Engl J Med2019-04-18T00:00:002019Opioid Tolerance in Critical Illness. Reply.D009469Anatomy1753980.806486Neuromuscular JunctionD002056Disorders37418080.431978BurnsD018482Anatomy152249200.327907Muscle, SkeletalAnaesthesiaNeurologyPhysical Medicine and RehabilitationSurgeryBeth Israel Deaconess Medical CenterBoston Children's HospitalMassachusetts General HospitalSpaulding Rehabilitation Hospital11174selected publications6.728990.00125784599research areas4.52110.016490233coauthor of149.24414.426460similar toRLS11RobertSheridanRobert L. Sheridan, M.D.42.36310000000000-71.0665000000000027709Sheridan, RobertProfessor of SurgeryJCS14JeffreySchneiderJeffrey C. Schneider, M.D.42.36780000000000-71.0649000000000085930Schneider, JeffreyAssociate Professor of Physical Medicine and RehabilitationSDS5SulpicioSorianoSulpicio De Guzman Soriano, III, M.D.42.33743600000000-71.1054470000000072131Soriano, SulpicioProfessor of AnaesthesiaCV28ChristaNehsChrista Nehs, Ph.D.42.36241700000000-71.068937000000007Nehs, ChristaAssistant Professor of AnaesthesiaAuthorship 1507972JG67JeremyGovermanJeremy Goverman, M.D.42.36241700000000-71.0689370000000053448Goverman, JeremyAssociate Professor of SurgerySBR1SewardRutkoveSeward Brian Rutkove, M.D.42.34022770000000-71.1058540000000028388Rutkove, SewardNancy Lurie Marks Professor of NeurologyJM29JianrenMaoJianren Mao, M.D., Ph.D.42.36220530000000-71.0672584000000018344Mao, JianrenRichard J. Kitz Professor of Anaesthesia ResearchWB7WilliamBenedettoWilliam Benedetto, M.D.42.36241700000000-71.068937000000004090Benedetto, WilliamAssistant Professor of AnaesthesiaSY7ShingoYasuharaShingo Yasuhara, M.D.42.36310000000000-71.0665000000000018015Yasuhara, ShingoAssistant Professor of AnaesthesiaAN71AkitoNakagawaAkito Nakagawa, Ph.D.42.36241700000000-71.0689370000000031634Nakagawa, AkitoAssistant Professor of AnaesthesiaKCD1KevinDennehyKevin C. Dennehy, M.D.42.36241700000000-71.0689370000000054410Dennehy, KevinInstructor in Anaesthesia, Part-timeEAB3EdwardBittnerEdward Alvah Bittner, M.D., Ph.D.42.36241700000000-71.0689370000000042342Bittner, EdwardAssociate Professor of AnaesthesiaNMS1NathanielSimsNathaniel Merriman Sims, M.D.42.36241700000000-71.068937000000002671Sims, NathanielAssociate Professor of AnaesthesiaCMR5ColleenRyanColleen M. Ryan, M.D.42.36220530000000-71.0672584000000081967Ryan, ColleenProfessor of SurgeryAuthorship 137111Authorship 1436644Authorship 1195082431577450Sakuma M, Khan MAS, Yasuhara S, Martyn JA, Palaniyar NFASEB journal : official publication of the Federation of American Societies for Experimental BiologyMechanism of pulmonary immunosuppression: extrapulmonary burn injury suppresses bacterial endotoxin-induced pulmonary neutrophil recruitment and neutrophil extracellular trap (NET) formation. FASEB J. 2019 12; 33(12):13602-13616.FASEB J2019-10-02T00:00:002019Mechanism of pulmonary immunosuppression: extrapulmonary burn injury suppresses bacterial endotoxin-induced pulmonary neutrophil recruitment and neutrophil extracellular trap (NET) formation.Authorship 1122883Authorship 1127634Authorship 1618595true1Instructor in Anaesthesia, Part-timeInstructor in Anaesthesia, Part-timetrue1Professor of AnaesthesiaProfessor of Anaesthesiatrue1Assistant Professor of AnaesthesiaAssistant Professor of Anaesthesiatrue1Associate Professor of Physical Medicine and RehabilitationAssociate Professor of Physical Medicine and Rehabilitationtrue1Associate Professor of AnaesthesiaAssociate Professor of Anaesthesiatrue1Assistant Professor of AnaesthesiaAssistant Professor of Anaesthesiatrue1Associate Professor of AnaesthesiaAssociate Professor of Anaesthesiatrue1Richard J. Kitz Professor of Anaesthesia ResearchRichard J. Kitz Professor of Anaesthesia Researchtrue1Assistant Professor of AnaesthesiaAssistant Professor of Anaesthesiatrue1Professor of SurgeryProfessor of Surgerytrue1Assistant Professor of AnaesthesiaAssistant Professor of Anaesthesiatrue1Professor of SurgeryProfessor of SurgeryAuthorship 12762Authorship 1284871Authorship 130032131815254Martyn JAJ, Mao J, Bittner EAThe New England journal of medicineOpioid Tolerance in Critical Illness. N Engl J Med. 2019; 380.N Engl J Med2019-04-18T00:00:002019Opioid Tolerance in Critical Illness.Authorship 12117561Authorship 1804252Authorship 1856201Authorship 1481782Authorship 1492577Authorship 1842032Authorship 1874781Authorship 1342733Authorship 1289654132966727Martyn JAJ, Kaneki MThe New England journal of medicineMuscle Atrophy and the Sestrins. N Engl J Med. 2020 09 24; 383(13):1279-1282.N Engl J Med2020-09-24T00:00:002020Muscle Atrophy and the Sestrins.true1Associate Professor of SurgeryAssociate Professor of SurgeryAuthorship 13085731033264122Zhou Y, Leung-Pitt Y, Deng H, Ren Y, You Z, Kem WR, Shen S, Zhang W, Mao J, Martyn JAJAnesthesia and analgesiaNonopioid GTS-21 Mitigates Burn Injury Pain in Rats by Decreasing Spinal Cord Inflammatory Responses. Anesth Analg. 2021 01; 132(1):240-252.Anesth Analg2021-01-01T00:00:002021Nonopioid GTS-21 Mitigates Burn Injury Pain in Rats by Decreasing Spinal Cord Inflammatory Responses.Authorship 1387369334413274Yasuhara S, Alston TA, Martyn JAJCritical care medicineFreshly Isolated Mitochondria as Therapeutic Agents in Sepsis: Can They Go Home Again? Crit Care Med. 2021 09 01; 49(9):1584-1587.Crit Care Med2021-09-01T00:00:002021Freshly Isolated Mitochondria as Therapeutic Agents in Sepsis: Can They Go Home Again?Authorship 2023422Authorship 1588251Authorship 2756502Authorship 293456636175185Martyn JAJ, Sparling JL, Bittner EABritish journal of anaesthesiaMolecular mechanisms of muscular and non-muscular actions of neuromuscular blocking agents in critical illness. Br J Anaesth. 2022 Sep 26.Br J Anaesth2022-09-26T00:00:002022Molecular mechanisms of muscular and non-muscular actions of neuromuscular blocking agents in critical illness.Authorship 14991648Authorship 1500977136243579Ren Y, Zhou Y, You Z, Deng H, Kem WR, Mao J, Zhang W, Martyn JAJBritish journal of anaesthesiaThe nonopioid cholinergic agonist GTS-21 mitigates morphine-induced aggravation of burn injury pain together with inhibition of spinal microglia activation in young rats. Br J Anaesth. 2022 12; 129(6):959-969.Br J Anaesth2022-10-13T00:00:002022The nonopioid cholinergic agonist GTS-21 mitigates morphine-induced aggravation of burn injury pain together with inhibition of spinal microglia activation in young rats.Authorship 2054823Authorship 1897302Authorship 5086868Authorship 15668125Authorship 1551171436967414Grunow JJ, Gan T, Lewald H, Martyn JAJ, Blobner M, Schaller SJIntensive care medicine experimentalInsulin signaling in skeletal muscle during inflammation and/or immobilisation. Intensive Care Med Exp. 2023 Mar 27; 11(1):16.Intensive Care Med Exp2023-03-27T00:00:002023Insulin signaling in skeletal muscle during inflammation and/or immobilisation.37085137Fan L, Gokaltun A, Maggipinto S, Kitagawa Y, Martyn J, Yeh H, Uygun BE, Yarmush ML, Usta OBCellular and molecular gastroenterology and hepatologyAlterations in Cytoskeleton and Mitochondria in the Development and Reversal of Steatosis in Human Hepatocytes. Cell Mol Gastroenterol Hepatol. 2023; 16(2):243-261.Cell Mol Gastroenterol Hepatol2023-04-20T00:00:002023Alterations in Cytoskeleton and Mitochondria in the Development and Reversal of Steatosis in Human Hepatocytes.Authorship 2836484Authorship 2971001Authorship 3714191Authorship 3719531true1Nancy Lurie Marks Professor of NeurologyNancy Lurie Marks Professor of NeurologyAuthorship 5348182true1Professor of AnaesthesiaProfessor of AnaesthesiaAuthorship 5496229Authorship 1679662Authorship 361023Authorship 3932282Authorship 2362281Authorship 4380962Authorship 358774222929526Shank ES, Sheridan RL, Ryan CM, Keaney TJ, Martyn JAJournal of burn care & research : official publication of the American Burn AssociationHemodynamic responses to dexmedetomidine in critically injured intubated pediatric burned patients: a preliminary study. J Burn Care Res. 2013 May-Jun; 34(3):311-7.J Burn Care Res2013-05-01T00:00:002013Hemodynamic responses to dexmedetomidine in critically injured intubated pediatric burned patients: a preliminary study.23512808Hosokawa S, Koseki H, Nagashima M, Maeyama Y, Yomogida K, Mehr C, Rutledge M, Greenfeld H, Kaneki M, Tompkins RG, Martyn JA, Yasuhara SEAmerican journal of physiology. Endocrinology and metabolismTitle efficacy of phosphodiesterase 5 inhibitor on distant burn-induced muscle autophagy, microcirculation, and survival rate. Am J Physiol Endocrinol Metab. 2013 May 01; 304(9):E922-33.Am J Physiol Endocrinol Metab2013-03-19T00:00:002013Title efficacy of phosphodiesterase 5 inhibitor on distant burn-induced muscle autophagy, microcirculation, and survival rate.23477960Nagashima M, Yasuhara S, Martyn JAJAnesthesia and analgesiaTrain-of-four and tetanic fade are not always a prejunctional phenomenon as evaluated by toxins having highly specific pre- and postjunctional actions. Anesth Analg. 2013 May; 116(5):994-1000.Anesth Analg2013-03-11T00:00:002013Train-of-four and tetanic fade are not always a prejunctional phenomenon as evaluated by toxins having highly specific pre- and postjunctional actions.23401051Zhu S, Nagashima M, Khan MA, Yasuhara S, Kaneki M, Martyn JAMuscle & nerveLack of caspase-3 attenuates immobilization-induced muscle atrophy and loss of tension generation along with mitigation of apoptosis and inflammation. Muscle Nerve. 2013 May; 47(5):711-21.Muscle Nerve2013-02-09T00:00:002013Lack of caspase-3 attenuates immobilization-induced muscle atrophy and loss of tension generation along with mitigation of apoptosis and inflammation.Authorship 929662Authorship 196838Authorship 559729124098655Tzika AA, Constantinou C, Bandyopadhaya A, Psychogios N, Lee S, Mindrinos M, Martyn JA, Tompkins RG, Rahme LGPloS oneA small volatile bacterial molecule triggers mitochondrial dysfunction in murine skeletal muscle. PLoS One. 2013; 8(9):e74528.PLoS One2013-09-30T00:00:002013A small volatile bacterial molecule triggers mitochondrial dysfunction in murine skeletal muscle.23563362Richtsfeld M, Yasuhara S, Fink H, Blobner M, Martyn JAAnesthesiologyProlonged administration of pyridostigmine impairs neuromuscular function with and without down-regulation of acetylcholine receptors. Anesthesiology. 2013 Aug; 119(2):412-21.Anesthesiology2013-08-01T00:00:002013Prolonged administration of pyridostigmine impairs neuromuscular function with and without down-regulation of acetylcholine receptors.Authorship 6870167Authorship 6884026Authorship 6874522Authorship 6874913Authorship 6891685Authorship 69001311Authorship 6859475Authorship 3051158Authorship 2259745Authorship 185382Authorship 700071824383867Khan MA, Sahani N, Neville KA, Nagashima M, Lee S, Sasakawa T, Kaneki M, Martyn JACanadian journal of physiology and pharmacologyNonsurgically induced disuse muscle atrophy and neuromuscular dysfunction upregulates alpha7 acetylcholine receptors. Can J Physiol Pharmacol. 2014 Jan; 92(1):1-8.Can J Physiol Pharmacol2013-08-13T00:00:002013Nonsurgically induced disuse muscle atrophy and neuromuscular dysfunction upregulates alpha7 acetylcholine receptors.Authorship 702110724126263Lee S, Yang HS, Sasakawa T, Khan MA, Khatri A, Kaneki M, Martyn JAAnesthesiologyImmobilization with atrophy induces de novo expression of neuronal nicotinic a7 acetylcholine receptors in muscle contributing to neurotransmission. Anesthesiology. 2014 Jan; 120(1):76-85.Anesthesiology2014-01-01T00:00:002014Immobilization with atrophy induces de novo expression of neuronal nicotinic a7 acetylcholine receptors in muscle contributing to neurotransmission.Authorship 2489762Authorship 2597893Authorship 2672084Authorship 3063513Authorship 725893524713351Song L, Wang S, Zuo Y, Chen L, Martyn JA, Mao JBrain researchMidazolam exacerbates morphine tolerance and morphine-induced hyperactive behaviors in young rats with burn injury. Brain Res. 2014 May 20; 1564:52-61.Brain Res2014-04-05T00:00:002014Midazolam exacerbates morphine tolerance and morphine-induced hyperactive behaviors in young rats with burn injury.Authorship 2670492Authorship 4737451Authorship 5538642Authorship 5698396Authorship 770195725188001Ueda M, Iwasaki H, Wang S, Murata E, Poon KY, Mao J, Martyn JAAnesthesiologyCannabinoid receptor type 1 antagonist, AM251, attenuates mechanical allodynia and thermal hyperalgesia after burn injury. Anesthesiology. 2014 Dec; 121(6):1311-9.Anesthesiology2014-12-01T00:00:002014Cannabinoid receptor type 1 antagonist, AM251, attenuates mechanical allodynia and thermal hyperalgesia after burn injury.25485468Bittner EA, Shank E, Woodson L, Martyn JAAnesthesiologyAcute and perioperative care of the burn-injured patient. Anesthesiology. 2015 Feb; 122(2):448-64.Anesthesiology2015-02-01T00:00:002015Acute and perioperative care of the burn-injured patient.Authorship 4614161Authorship 3237312Authorship 4378802Authorship 4334181Authorship 5090641Authorship 1846505Authorship 5644424Authorship 17785610Authorship 2308864Authorship 5500491Authorship 5523765Authorship 497462Authorship 234209Authorship 2501273Authorship 2769964Authorship 2459492Authorship 2539792Authorship 2226242Authorship 3789262Authorship 4903325Authorship 344484Authorship 5937Authorship 2522888Authorship 2925204Authorship 3553791Authorship 4345521Authorship 39647710Authorship 2440198Authorship 2257935Authorship 2300371Authorship 2531651Authorship 2975732Authorship 3886814Authorship 4793791Authorship 2768102Authorship 2387413Authorship 3593041Authorship 5125825Authorship 5257064Authorship 7998827Authorship 7977264Authorship 792207625501690Kashiwagi A, Hosokawa S, Maeyama Y, Ueki R, Kaneki M, Martyn JA, Yasuhara SAnesthesiologyAnesthesia with Disuse Leads to Autophagy Up-regulation in the Skeletal Muscle. Anesthesiology. 2015 May; 122(5):1075-83.Anesthesiology2015-05-01T00:00:002015Anesthesia with Disuse Leads to Autophagy Up-regulation in the Skeletal Muscle.25594415Nakazawa H, Yamada M, Tanaka T, Kramer J, Yu YM, Fischman AJ, Martyn JA, Tompkins RG, Kaneki MPloS oneRole of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS One. 2015; 10(1):e0116633.PLoS One2015-01-16T00:00:002015Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle.Authorship 3288001Authorship 2920762Authorship 4612075Authorship 4716632Authorship 516196Authorship 541622Authorship 5613251Authorship 811061425835024Nagashima M, Sasakawa T, Schaller SJ, Martyn JABritish journal of anaesthesiaBlock of postjunctional muscle-type acetylcholine receptors in vivo causes train-of-four fade in mice. Br J Anaesth. 2015 Jul; 115(1):122-7.Br J Anaesth2015-04-01T00:00:002015Block of postjunctional muscle-type acetylcholine receptors in vivo causes train-of-four fade in mice.Authorship 4843842Authorship 3462154Authorship 4666211Authorship 4764385Authorship 4765031Authorship 5054371Authorship 5264221Authorship 5404672Authorship 618027Authorship 3755913Authorship 3806356Authorship 4436252Authorship 4456452Authorship 500032Authorship 538766125412051Shank ES, Martyn JA, Donelan MB, Perrone A, Firth PG, Driscoll DNJournal of burn care & research : official publication of the American Burn AssociationUltrasound-Guided Regional Anesthesia for Pediatric Burn Reconstructive Surgery: A Prospective Study. J Burn Care Res. 2016 May-Jun; 37(3):e213-7.J Burn Care Res2016-05-01T00:00:002016Ultrasound-Guided Regional Anesthesia for Pediatric Burn Reconstructive Surgery: A Prospective Study.Authorship 5041282Authorship 318227326935176Bandyopadhaya A, Constantinou C, Psychogios N, Ueki R, Yasuhara S, Martyn JA, Wilhelmy J, Mindrinos M, Rahme LG, Tzika AAInternational journal of molecular medicineBacterial-excreted small volatile molecule 2-aminoacetophenone induces oxidative stress and apoptosis in murine skeletal muscle. Int J Mol Med. 2016 Apr; 37(4):867-78.Int J Mol Med2016-02-12T00:00:002016Bacterial-excreted small volatile molecule 2-aminoacetophenone induces oxidative stress and apoptosis in murine skeletal muscle.Authorship 8740496Authorship 4055584Authorship 8788522Authorship 4677361Authorship 4860882Authorship 5198744Authorship 5750464Authorship 57627952Assistant Professor1Associate Professor0Full Professor4InstructorAuthorship 52252Authorship 5767675Authorship 747842Authorship 5450555Authorship 5574493Authorship 5607465Authorship 916553827172157Ueki R, Liu L, Kashiwagi S, Kaneki M, Khan MA, Hirose M, Tompkins RG, Martyn JA, Yasuhara SShock (Augusta, Ga.)Role of Elevated Fibrinogen in Burn-Induced Mitochondrial Dysfunction: Protective Effects of Glycyrrhizin. Shock. 2016 10; 46(4):382-9.Shock2016-10-01T00:00:002016Role of Elevated Fibrinogen in Burn-Induced Mitochondrial Dysfunction: Protective Effects of Glycyrrhizin.Authorship 638906Authorship 3394451Authorship 922235327513355Stäuble CG, Helming M, Martyn JA, Blobner M, Fink HCritical care medicineNeuromuscular Recovery Is Prolonged After Immobilization or Superimposition of Inflammation With Immobilization Compared to Inflammation Alone: Data From a Preclinical Model. Crit Care Med. 2016 Nov; 44(11):e1097-e1110.Crit Care Med2016-11-01T00:00:002016Neuromuscular Recovery Is Prolonged After Immobilization or Superimposition of Inflammation With Immobilization Compared to Inflammation Alone: Data From a Preclinical Model.Authorship 446921Authorship 937633727891611Schaller SJ, Alam SM, Mao J, Zhao Y, Blobner M, Greenblatt DJ, Martyn JAThe Journal of pharmacy and pharmacologyPharmacokinetics cannot explain the increased effective dose requirement for morphine and midazolam in rats during their extended administration alone or in combination. J Pharm Pharmacol. 2017 Jan; 69(1):82-88.J Pharm Pharmacol2016-11-28T00:00:002016Pharmacokinetics cannot explain the increased effective dose requirement for morphine and midazolam in rats during their extended administration alone or in combination.Authorship 2086269Authorship 943500827529131Kashiwagi S, Khan MA, Yasuhara S, Goto T, Kem WR, Tompkins RG, Kaneki M, Martyn JAShock (Augusta, Ga.)Prevention of Burn-Induced Inflammatory Responses and Muscle Wasting by GTS-21, a Specific Agonist for a7 Nicotinic Acetylcholine Receptors. Shock. 2017 01; 47(1):61-69.Shock2017-01-01T00:00:002017Prevention of Burn-Induced Inflammatory Responses and Muscle Wasting by GTS-21, a Specific Agonist for a7 Nicotinic Acetylcholine Receptors.Authorship 5059774Authorship 950877828099528Nakazawa H, Chang K, Shinozaki S, Yasukawa T, Ishimaru K, Yasuhara S, Yu YM, Martyn JA, Tompkins RG, Shimokado K, Kaneki MPloS oneiNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-?B and p53. PLoS One. 2017; 12(1):e0170391.PLoS One2017-01-18T00:00:002017iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-?B and p53.Authorship 5680728880816Yang HS, Goudsouzian NG, Cheng M, Martyn JAPaediatric anaesthesiaThe influence of the age of the rat on the neuromuscular response to mivacurium in vitro. Paediatr Anaesth. 1996; 6(5):367-72.Paediatr Anaesth1996-01-01T00:00:001996The influence of the age of the rat on the neuromuscular response to mivacurium in vitro.8781985Oldham JM, Martyn JA, Napier JR, Bass JJGrowth regulationPostnatal age and food intake alter insulin-like growth factor-II/mannose-6-phosphate receptors in ovine skeletal muscles. Growth Regul. 1996 Jun; 6(2):88-95.Growth Regul1996-06-01T00:00:001996Postnatal age and food intake alter insulin-like growth factor-II/mannose-6-phosphate receptors in ovine skeletal muscles.11788371Sugita H, Kaneki M, Tokunaga E, Sugita M, Koike C, Yasuhara S, Tompkins RG, Martyn JAAmerican journal of physiology. Endocrinology and metabolismInducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance. Am J Physiol Endocrinol Metab. 2002 Feb; 282(2):E386-94.Am J Physiol Endocrinol Metab2002-02-01T00:00:002002Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance.15166588Yasukawa T, Kaneki M, Yasuhara S, Lee SL, Martyn JAAnesthesiologySteroidal nondepolarizing muscle relaxants do not simulate the effects of glucocorticoids on glucocorticoid receptor-mediated transcription in cultured skeletal muscle cells. Anesthesiology. 2004 Jun; 100(6):1615-9.Anesthesiology2004-06-01T00:00:002004Steroidal nondepolarizing muscle relaxants do not simulate the effects of glucocorticoids on glucocorticoid receptor-mediated transcription in cultured skeletal muscle cells.15805118Sugita H, Fujimoto M, Yasukawa T, Shimizu N, Sugita M, Yasuhara S, Martyn JA, Kaneki MThe Journal of biological chemistryInducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells. J Biol Chem. 2005 Apr 08; 280(14):14203-11.J Biol Chem2005-02-01T00:00:002005Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells.11052967Yasuhara S, Perez ME, Kanakubo E, Yasuhara Y, Shin YS, Kaneki M, Fujita T, Martyn JAAmerican journal of physiology. Endocrinology and metabolismSkeletal muscle apoptosis after burns is associated with activation of proapoptotic signals. Am J Physiol Endocrinol Metab. 2000 Nov; 279(5):E1114-21.Am J Physiol Endocrinol Metab2000-11-01T00:00:002000Skeletal muscle apoptosis after burns is associated with activation of proapoptotic signals.11229432Hirose M, Kaneki M, Sugita H, Yasuhara S, Ibebunjo C, Martyn JA, Iebunjo CMetabolism: clinical and experimentalLong-term denervation impairs insulin receptor substrate-1-mediated insulin signaling in skeletal muscle. Metabolism. 2001 Feb; 50(2):216-22.Metabolism2001-02-01T00:00:002001Long-term denervation impairs insulin receptor substrate-1-mediated insulin signaling in skeletal muscle.9243359Goudsouzian N, Martyn JAJournal of clinical pharmacologyPotentiation of mivacurium by rocuronium is age- and time-dependent: a study in children, adolescents, and young and elderly adults. J Clin Pharmacol. 1997 Jul; 37(7):649-55.J Clin Pharmacol1997-07-01T00:00:001997Potentiation of mivacurium by rocuronium is age- and time-dependent: a study in children, adolescents, and young and elderly adults.Authorship 967801828282360Khan MAS, Khan MF, Kashiwagi S, Kem WR, Yasuhara S, Kaneki M, Tompkins RG, Martyn JAJShock (Augusta, Ga.)An ALPHA7 Nicotinic Acetylcholine Receptor Agonist (GTS-21) Promotes C2C12 Myonuclear Accretion in Association with Release of Interleukin-6 (IL-6) and Improves Survival in Burned Mice. Shock. 2017 08; 48(2):227-235.Shock2017-08-01T00:00:002017An ALPHA7 Nicotinic Acetylcholine Receptor Agonist (GTS-21) Promotes C2C12 Myonuclear Accretion in Association with Release of Interleukin-6 (IL-6) and Improves Survival in Burned Mice.10910842Shin YS, Fink H, Khiroya R, Ibebunjo C, Martyn JAnesthesia and analgesiaPrednisolone-induced muscle dysfunction is caused more by atrophy than by altered acetylcholine receptor expression. Anesth Analg. 2000 Aug; 91(2):322-8.Anesth Analg2000-08-01T00:00:002000Prednisolone-induced muscle dysfunction is caused more by atrophy than by altered acetylcholine receptor expression.16679908Yasuhara S, Kaneki M, Sugita H, Sugita M, Asai A, Sahani N, Chon JY, Tompkins RG, Martyn JAJournal of burn care & research : official publication of the American Burn AssociationAdipocyte apoptosis after burn injury is associated with altered fat metabolism. J Burn Care Res. 2006 May-Jun; 27(3):367-76.J Burn Care Res2006-05-01T00:00:002006Adipocyte apoptosis after burn injury is associated with altered fat metabolism.11093909Hirose M, Kaneki M, Sugita H, Yasuhara S, Martyn JAAmerican journal of physiology. Endocrinology and metabolismImmobilization depresses insulin signaling in skeletal muscle. Am J Physiol Endocrinol Metab. 2000 Dec; 279(6):E1235-41.Am J Physiol Endocrinol Metab2000-12-01T00:00:002000Immobilization depresses insulin signaling in skeletal muscle.18580184Martyn JA, Kaneki M, Yasuhara SAnesthesiologyObesity-induced insulin resistance and hyperglycemia: etiologic factors and molecular mechanisms. Anesthesiology. 2008 Jul; 109(1):137-48.Anesthesiology2008-07-01T00:00:002008Obesity-induced insulin resistance and hyperglycemia: etiologic factors and molecular mechanisms.9312146Ikezu T, Okamoto T, Yonezawa K, Tompkins RG, Martyn JAThe Journal of biological chemistryAnalysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms. J Biol Chem. 1997 Oct 03; 272(40):25289-95.J Biol Chem1997-10-03T00:00:001997Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms.10075050Ibebunjo C, Martyn JACritical care medicineFiber atrophy, but not changes in acetylcholine receptor expression, contributes to the muscle dysfunction after immobilization. Crit Care Med. 1999 Feb; 27(2):275-85.Crit Care Med1999-02-01T00:00:001999Fiber atrophy, but not changes in acetylcholine receptor expression, contributes to the muscle dysfunction after immobilization.10443592Martyn JA, Vincent AAnesthesiologyA new twist to myopathy of critical illness. Anesthesiology. 1999 Aug; 91(2):337-9.Anesthesiology1999-08-01T00:00:001999A new twist to myopathy of critical illness.11882804Stoddard FJ, Sheridan RL, Saxe GN, King BS, King BH, Chedekel DS, Schnitzer JJ, Martyn JAThe Journal of burn care & rehabilitationTreatment of pain in acutely burned children. J Burn Care Rehabil. 2002 Mar-Apr; 23(2):135-56.J Burn Care Rehabil2002-03-01T00:00:002002Treatment of pain in acutely burned children.11562907Ibebunjo C, Martyn JMuscle & nerveDisparate dysfunction of skeletal muscles located near and distant from burn site in the rat. Muscle Nerve. 2001 Oct; 24(10):1283-94.Muscle Nerve2001-10-01T00:00:002001Disparate dysfunction of skeletal muscles located near and distant from burn site in the rat.Authorship 9815091128498256Bonaventura A, O'Connell RL, Mapagu C, Beale PJ, McNally OM, Mileshkin LR, Grant PT, Hadley AM, Goh JCH, Sjoquist KM, Martyn J, DeFazio A, Scurry J, Friedlander MLInternational journal of gynecological cancer : official journal of the International Gynecological Cancer SocietyParagon (ANZGOG-0903): Phase 2 Study of Anastrozole in Women With Estrogen or Progesterone Receptor-Positive Platinum-Resistant or -Refractory Recurrent Ovarian Cancer. Int J Gynecol Cancer. 2017 06; 27(5):900-906.Int J Gynecol Cancer2017-06-01T00:00:002017Paragon (ANZGOG-0903): Phase 2 Study of Anastrozole in Women With Estrogen or Progesterone Receptor-Positive Platinum-Resistant or -Refractory Recurrent Ovarian Cancer.16243995Fink H, Bogdanski R, Luppa P, Martyn JAJ, Blobner MAnesthesia and analgesiaNitric oxide is not a mediator of inflammation-induced resistance to atracurium. Anesth Analg. 2005 Nov; 101(5):1362-1367.Anesth Analg2005-11-01T00:00:002005Nitric oxide is not a mediator of inflammation-induced resistance to atracurium.9171825du Sart D, Cancilla MR, Earle E, Mao JI, Saffery R, Tainton KM, Kalitsis P, Martyn J, Barry AE, Choo KHNature geneticsA functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA. Nat Genet. 1997 Jun; 16(2):144-53.Nat Genet1997-06-01T00:00:001997A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA.10444428Ikezu T, Yasuhara S, Granneman JG, Kraemer FB, Okamoto T, Tompkins RG, Martyn JAThe American journal of physiologyA unique mechanism of desensitization to lipolysis mediated by beta(3)-adrenoceptor in rats with thermal injury. Am J Physiol. 1999 08; 277(2):E316-24.Am J Physiol1999-08-01T00:00:001999A unique mechanism of desensitization to lipolysis mediated by beta(3)-adrenoceptor in rats with thermal injury.55 Fruit StMassachusetts General HospitalDept of Anaesthesia55 Fruit StBoston02114MA12810838Yasuhara S, Zhu Y, Matsui T, Tipirneni N, Yasuhara Y, Kaneki M, Rosenzweig A, Martyn JAThe journal of histochemistry and cytochemistry : official journal of the Histochemistry SocietyComparison of comet assay, electron microscopy, and flow cytometry for detection of apoptosis. J Histochem Cytochem. 2003 Jul; 51(7):873-85.J Histochem Cytochem2003-07-01T00:00:002003Comparison of comet assay, electron microscopy, and flow cytometry for detection of apoptosis.1519788Kim CS, Arnold FJ, Itani MS, Martyn JAAnesthesiologyDecreased sensitivity to metocurine during long-term phenytoin therapy may be attributable to protein binding and acetylcholine receptor changes. Anesthesiology. 1992 Sep; 77(3):500-6.Anesthesiology1992-09-01T00:00:001992Decreased sensitivity to metocurine during long-term phenytoin therapy may be attributable to protein binding and acetylcholine receptor changes.19222426Martyn JA, Fagerlund MJ, Eriksson LIAnaesthesiaBasic principles of neuromuscular transmission. Anaesthesia. 2009 Mar; 64 Suppl 1:1-9.Anaesthesia2009-03-01T00:00:002009Basic principles of neuromuscular transmission.2844362Tomera JF, Martyn JBurns, including thermal injurySystemic effects of single hindlimb burn injury on skeletal muscle function and cyclic nucleotide levels in the murine model. Burns Incl Therm Inj. 1988 Jun; 14(3):210-9.Burns Incl Therm Inj1988-06-01T00:00:001988Systemic effects of single hindlimb burn injury on skeletal muscle function and cyclic nucleotide levels in the murine model.1760105Tomera JF, Martyn JBurns : journal of the International Society for Burn InjuriesGastrocnemius acetylcholinesterase activity in response to burn trauma in the mouse. Burns. 1991 Oct; 17(5):371-9.Burns1991-10-01T00:00:001991Gastrocnemius acetylcholinesterase activity in response to burn trauma in the mouse.1963121Tomera JF, Martyn JCirculatory shockEffects of endotoxin infection on cyclic nucleotides in ventricular and gastrocnemius muscle. Circ Shock. 1990 Dec; 32(4):281-92.Circ Shock1990-12-01T00:00:001990Effects of endotoxin infection on cyclic nucleotides in ventricular and gastrocnemius muscle.6824985Lebowitz PW, Cote ME, Daniels AL, Martyn JA, Teplick RS, Davison JK, Sunder NCanadian Anaesthetists' Society journalCardiovascular effects of midazolam and thiopentone for induction of anaesthesia in ill surgical patients. Can Anaesth Soc J. 1983 Jan; 30(1):19-23.Can Anaesth Soc J1983-01-01T00:00:001983Cardiovascular effects of midazolam and thiopentone for induction of anaesthesia in ill surgical patients.7265333Martyn JA, Snider MT, Farago LF, Burke JFThe Journal of traumaThermodilution right ventricular volume: a novel and better predictor of volume replacement in acute thermal injury. J Trauma. 1981 Aug; 21(8):619-26.J Trauma1981-08-01T00:00:001981Thermodilution right ventricular volume: a novel and better predictor of volume replacement in acute thermal injury.8565516Wang C, Martyn JACritical care medicineBurn injury alters beta-adrenergic receptor and second messenger function in rat ventricular muscle. Crit Care Med. 1996 Jan; 24(1):118-24.Crit Care Med1996-01-01T00:00:001996Burn injury alters beta-adrenergic receptor and second messenger function in rat ventricular muscle.17713398Yasuhara S, Asai A, Sahani ND, Martyn JACritical care medicineMitochondria, endoplasmic reticulum, and alternative pathways of cell death in critical illness. Crit Care Med. 2007 Sep; 35(9 Suppl):S488-95.Crit Care Med2007-09-01T00:00:002007Mitochondria, endoplasmic reticulum, and alternative pathways of cell death in critical illness.22003222Frick CG, Fink H, Blobner M, Martyn JAnesthesia and analgesiaA single injection of botulinum toxin decreases the margin of safety of neurotransmission at local and distant sites. Anesth Analg. 2012 Jan; 114(1):102-9.Anesth Analg2011-10-14T00:00:002011A single injection of botulinum toxin decreases the margin of safety of neurotransmission at local and distant sites.21816442Sugita M, Sugita H, Kim M, Mao J, Yasuda Y, Habiro M, Shinozaki S, Yasuhara S, Shimizu N, Martyn JA, Kaneki MMetabolism: clinical and experimentalInducible nitric oxide synthase deficiency ameliorates skeletal muscle insulin resistance but does not alter unexpected lower blood glucose levels after burn injury in C57BL/6 mice. Metabolism. 2012 Jan; 61(1):127-36.Metabolism2011-08-03T00:00:002011Inducible nitric oxide synthase deficiency ameliorates skeletal muscle insulin resistance but does not alter unexpected lower blood glucose levels after burn injury in C57BL/6 mice.3172313Tomera JF, Martyn J, Hoaglin DCThe Journal of traumaNeuromuscular dysfunction in burns and its relationship to burn size, hypermetabolism, and immunosuppression. J Trauma. 1988 Oct; 28(10):1499-504.J Trauma1988-10-01T00:00:001988Neuromuscular dysfunction in burns and its relationship to burn size, hypermetabolism, and immunosuppression.3968854Martyn JA, Greenblatt DJ, Abernethy DRJAMAIncreased cimetidine clearance in burn patients. JAMA. 1985 Mar 01; 253(9):1288-91.JAMA1985-03-01T00:00:001985Increased cimetidine clearance in burn patients.2802231Martyn JA, Tomera JFAnesthesiologyAcetylcholine receptor density and acetylcholinesterase enzyme activity in skeletal muscle of rats following thermal injury. Anesthesiology. 1989 Oct; 71(4):625-7.Anesthesiology1989-10-01T00:00:001989Acetylcholine receptor density and acetylcholinesterase enzyme activity in skeletal muscle of rats following thermal injury.7362055Martyn JA, Szyfelbein SK, Ali HH, Matteo RS, Savarese JJAnesthesiologyIncreased d-tubocurarine requirement following major thermal injury. Anesthesiology. 1980 Apr; 52(4):352-5.Anesthesiology1980-04-01T00:00:001980Increased d-tubocurarine requirement following major thermal injury.9353356Ibebunjo C, Nosek MT, Itani MS, Martyn JAThe Journal of pharmacology and experimental therapeuticsMechanisms for the paradoxical resistance to d-tubocurarine during immobilization-induced muscle atrophy. J Pharmacol Exp Ther. 1997 Nov; 283(2):443-51.J Pharmacol Exp Ther1997-11-01T00:00:001997Mechanisms for the paradoxical resistance to d-tubocurarine during immobilization-induced muscle atrophy.10638896Martyn JA, Goudsouzian NG, Chang Y, Szyfelbein SK, Schwartz AE, Patel SSAnesthesiologyNeuromuscular effects of mivacurium in 2- to 12-yr-old children with burn injury. Anesthesiology. 2000 Jan; 92(1):31-7.Anesthesiology2000-01-01T00:00:002000Neuromuscular effects of mivacurium in 2- to 12-yr-old children with burn injury.11294773Oldham JM, Martyn JA, Sharma M, Jeanplong F, Kambadur R, Bass JJAmerican journal of physiology. Regulatory, integrative and comparative physiologyMolecular expression of myostatin and MyoD is greater in double-muscled than normal-muscled cattle fetuses. Am J Physiol Regul Integr Comp Physiol. 2001 May; 280(5):R1488-93.Am J Physiol Regul Integr Comp Physiol2001-05-01T00:00:002001Molecular expression of myostatin and MyoD is greater in double-muscled than normal-muscled cattle fetuses.1858994Hogue CW, Martyn J, Baker TR, Vouros PAnesthesia and analgesiaRecovery of pancuronium from peritoneal dialysate in a severely burned child. Anesth Analg. 1991 Jul; 73(1):83-6.Anesth Analg1991-07-01T00:00:001991Recovery of pancuronium from peritoneal dialysate in a severely burned child.9313130Sheridan RL, Hinson M, Nackel A, Blaquiere M, Daley W, Querzoli B, Spezzafaro J, Lybarger P, Martyn J, Szyfelbein S, Tompkins RThe Journal of burn care & rehabilitationDevelopment of a pediatric burn pain and anxiety management program. J Burn Care Rehabil. 1997 Sep-Oct; 18(5):455-9; discussion 453-4.J Burn Care Rehabil1997-09-01T00:00:001997Development of a pediatric burn pain and anxiety management program.3728909Martyn JA, McKusick K, Strauss HW, Burke JFAnaesthesiaVentricular volume and ejection fraction in the diagnosis of the aetiology of low cardiac output in burned patients. Anaesthesia. 1986 May; 41(5):511-5.Anaesthesia1986-05-01T00:00:001986Ventricular volume and ejection fraction in the diagnosis of the aetiology of low cardiac output in burned patients.7194764Szyfelbein SK, Drop LJ, Martyn JACritical care medicinePersistent ionized hypocalcemia in patients during resuscitation and recovery phases of body burns. Crit Care Med. 1981 Jun; 9(6):454-8.Crit Care Med1981-06-01T00:00:001981Persistent ionized hypocalcemia in patients during resuscitation and recovery phases of body burns.7362298Martyn JA, Snider MT, Szyfelbein SK, Burke JF, Laver MBAnnals of surgeryRight ventricular dysfunction in acute thermal injury. Ann Surg. 1980 Mar; 191(3):330-5.Ann Surg1980-03-01T00:00:001980Right ventricular dysfunction in acute thermal injury.12393359Martyn JA, Chang Y, Goudsouzian NG, Patel SSBritish journal of anaesthesiaPharmacodynamics of mivacurium chloride in 13- to 18-yr-old adolescents with thermal injury. Br J Anaesth. 2002 Oct; 89(4):580-5.Br J Anaesth2002-10-01T00:00:002002Pharmacodynamics of mivacurium chloride in 13- to 18-yr-old adolescents with thermal injury.16394702Martyn JA, Richtsfeld MAnesthesiologySuccinylcholine-induced hyperkalemia in acquired pathologic states: etiologic factors and molecular mechanisms. Anesthesiology. 2006 Jan; 104(1):158-69.Anesthesiology2006-01-01T00:00:002006Succinylcholine-induced hyperkalemia in acquired pathologic states: etiologic factors and molecular mechanisms.15271712Han T, Kim H, Bae J, Kim K, Martyn JAAnesthesia and analgesiaNeuromuscular pharmacodynamics of rocuronium in patients with major burns. Anesth Analg. 2004 Aug; 99(2):386-92, table of contents.Anesth Analg2004-08-01T00:00:002004Neuromuscular pharmacodynamics of rocuronium in patients with major burns.15536206Sugita H, Kaneki M, Sugita M, Yasukawa T, Yasuhara S, Martyn JAAmerican journal of physiology. Endocrinology and metabolismBurn injury impairs insulin-stimulated Akt/PKB activation in skeletal muscle. Am J Physiol Endocrinol Metab. 2005 Mar; 288(3):E585-91.Am J Physiol Endocrinol Metab2004-11-09T00:00:002004Burn injury impairs insulin-stimulated Akt/PKB activation in skeletal muscle.17525589Frick CG, Richtsfeld M, Sahani ND, Kaneki M, Blobner M, Martyn JAAnesthesiologyLong-term effects of botulinum toxin on neuromuscular function. Anesthesiology. 2007 Jun; 106(6):1139-46.Anesthesiology2007-06-01T00:00:002007Long-term effects of botulinum toxin on neuromuscular function.2221439Hogue CW, Itani MS, Martyn JAAnesthesiologyResistance to d-tubocurarine in lower motor neuron injury is related to increased acetylcholine receptors at the neuromuscular junction. Anesthesiology. 1990 Oct; 73(4):703-9.Anesthesiology1990-10-01T00:00:001990Resistance to d-tubocurarine in lower motor neuron injury is related to increased acetylcholine receptors at the neuromuscular junction.18272897Sheridan RL, Ryan DP, Fuzaylov G, Nimkin K, Martyn JAThe New England journal of medicineCase records of the Massachusetts General Hospital. Case 5-2008. An 18-month-old girl with an advanced neck contracture after a burn. N Engl J Med. 2008 02 14; 358(7):729-35.N Engl J Med2008-02-14T00:00:002008Case records of the Massachusetts General Hospital. Case 5-2008. An 18-month-old girl with an advanced neck contracture after a burn.18431280Fink H, Helming M, Unterbuchner C, Lenz A, Neff F, Martyn JA, Blobner MCritical care medicineSystemic inflammatory response syndrome increases immobility-induced neuromuscular weakness. Crit Care Med. 2008 Mar; 36(3):910-6.Crit Care Med2008-03-01T00:00:002008Systemic inflammatory response syndrome increases immobility-induced neuromuscular weakness.9104873Nosek MT, Martyn JAJournal of applied physiology (Bethesda, Md. : 1985)Na+ channel and acetylcholine receptor changes in muscle at sites distant from burns do not simulate denervation. J Appl Physiol (1985). 1997 Apr; 82(4):1333-9.J Appl Physiol (1985)1997-04-01T00:00:001997Na+ channel and acetylcholine receptor changes in muscle at sites distant from burns do not simulate denervation.2341537Annan RS, Kim C, Martyn JJournal of chromatographyMeasurement of D-tubocurarine chloride in human urine using solid-phase extraction and reversed-phase high-performance liquid chromatography with ultraviolet detection. J Chromatogr. 1990 Mar 16; 526(1):228-34.J Chromatogr1990-03-16T00:00:001990Measurement of D-tubocurarine chloride in human urine using solid-phase extraction and reversed-phase high-performance liquid chromatography with ultraviolet detection.11976270Hirose M, Martyn JA, Kuroda Y, Marunaka Y, Tanaka YBritish journal of pharmacologyMechanism of suppression of insulin signalling with lignocaine. Br J Pharmacol. 2002 May; 136(1):76-80.Br J Pharmacol2002-05-01T00:00:002002Mechanism of suppression of insulin signalling with lignocaine.8638849Yang HS, Goudsouzian N, Martyn JAAnesthesiologyPseudocholinesterase-mediated hydrolysis is superior to neostigmine for reversal of mivacurium-induced paralysis in vitro. Anesthesiology. 1996 Apr; 84(4):936-44.Anesthesiology1996-04-01T00:00:001996Pseudocholinesterase-mediated hydrolysis is superior to neostigmine for reversal of mivacurium-induced paralysis in vitro.22479096Mabasa VH, Yokoyama S, Man D, Martyn JThe Canadian journal of hospital pharmacyAnalysis of Orders for QTc-Prolonging Medication for Intensive and Cardiac Care Unit Patients with Pre-existing QTc Prolongation (QTIPPP Study). Can J Hosp Pharm. 2011 Nov; 64(6):412-8.Can J Hosp Pharm2011-11-01T00:00:002011Analysis of Orders for QTc-Prolonging Medication for Intensive and Cardiac Care Unit Patients with Pre-existing QTc Prolongation (QTIPPP Study).20046117Bittner EA, Martyn JA, George E, Frontera WR, Eikermann MCritical care medicineMeasurement of muscle strength in the intensive care unit. Crit Care Med. 2009 Oct; 37(10 Suppl):S321-30.Crit Care Med2009-10-01T00:00:002009Measurement of muscle strength in the intensive care unit.19553403Han TH, Greenblatt DJ, Martyn JAJournal of clinical pharmacologyPropofol clearance and volume of distribution are increased in patients with major burns. J Clin Pharmacol. 2009 Jul; 49(7):768-72.J Clin Pharmacol2009-07-01T00:00:002009Propofol clearance and volume of distribution are increased in patients with major burns.2873763Martyn JAnesthesiologyClinical pharmacology and drug therapy in the burned patient. Anesthesiology. 1986 Jul; 65(1):67-75.Anesthesiology1986-07-01T00:00:001986Clinical pharmacology and drug therapy in the burned patient.21937949Lee HY, Kaneki M, Andreas J, Tompkins RG, Martyn JAShock (Augusta, Ga.)Novel mitochondria-targeted antioxidant peptide ameliorates burn-induced apoptosis and endoplasmic reticulum stress in the skeletal muscle of mice. Shock. 2011 Dec; 36(6):580-5.Shock2011-12-01T00:00:002011Novel mitochondria-targeted antioxidant peptide ameliorates burn-induced apoptosis and endoplasmic reticulum stress in the skeletal muscle of mice.6220728Martyn JA, Goudsouzian NG, Matteo RS, Liu LM, Szyfelbein SK, Kaplan RFBritish journal of anaesthesiaMetocurine requirements and plasma concentrations in burned paediatric patients. Br J Anaesth. 1983 Apr; 55(4):263-8.Br J Anaesth1983-04-01T00:00:001983Metocurine requirements and plasma concentrations in burned paediatric patients.8300694Ward JM, Rosen KM, Martyn JAThe Journal of burn care & rehabilitationAcetylcholine receptor subunit mRNA changes in burns are different from those seen after denervation: the 1993 Lindberg Award. J Burn Care Rehabil. 1993 Nov-Dec; 14(6):595-601.J Burn Care Rehabil1993-11-01T00:00:001993Acetylcholine receptor subunit mRNA changes in burns are different from those seen after denervation: the 1993 Lindberg Award.8046953Tomera JF, Kukulka SP, Lilford K, Martyn JAMethods and findings in experimental and clinical pharmacologyE. coli endotoxin affinity at the nicotinic2 receptor: receptor theory revisited, ilumina nostros occulae. Methods Find Exp Clin Pharmacol. 1994 Apr; 16(3):191-201.Methods Find Exp Clin Pharmacol1994-04-01T00:00:001994E. coli endotoxin affinity at the nicotinic2 receptor: receptor theory revisited, ilumina nostros occulae.8455647Ward JM, Martyn JAMuscle & nerveBurn injury-induced nicotinic acetylcholine receptor changes on muscle membrane. Muscle Nerve. 1993 Apr; 16(4):348-54.Muscle Nerve1993-04-01T00:00:001993Burn injury-induced nicotinic acetylcholine receptor changes on muscle membrane.19272533Shear TD, Martyn JAJournal of critical carePhysiology and biology of neuromuscular transmission in health and disease. J Crit Care. 2009 Mar; 24(1):5-10.J Crit Care2009-01-17T00:00:002009Physiology and biology of neuromuscular transmission in health and disease.11131134Smith HK, Maxwell L, Martyn JA, Bass JJCell and tissue researchNuclear DNA fragmentation and morphological alterations in adult rabbit skeletal muscle after short-term immobilization. Cell Tissue Res. 2000 Nov; 302(2):235-41.Cell Tissue Res2000-11-01T00:00:002000Nuclear DNA fragmentation and morphological alterations in adult rabbit skeletal muscle after short-term immobilization.1575351Martyn JA, White DA, Gronert GA, Jaffe RS, Ward JMAnesthesiologyUp-and-down regulation of skeletal muscle acetylcholine receptors. Effects on neuromuscular blockers. Anesthesiology. 1992 May; 76(5):822-43.Anesthesiology1992-05-01T00:00:001992Up-and-down regulation of skeletal muscle acetylcholine receptors. Effects on neuromuscular blockers.14748617Soriano SG, Martyn JAClinical pharmacokineticsAntiepileptic-induced resistance to neuromuscular blockers: mechanisms and clinical significance. Clin Pharmacokinet. 2004; 43(2):71-81.Clin Pharmacokinet2004-01-01T00:00:002004Antiepileptic-induced resistance to neuromuscular blockers: mechanisms and clinical significance.14758171Fink H, Yasuhara S, Blobner M, Martyn JACritical care medicineUp-regulation of acetylcholine receptors during subchronic infusion of pancuronium is caused by a posttranscriptional mechanism related to disuse. Crit Care Med. 2004 Feb; 32(2):509-13.Crit Care Med2004-02-01T00:00:002004Up-regulation of acetylcholine receptors during subchronic infusion of pancuronium is caused by a posttranscriptional mechanism related to disuse.16571955Martyn J, Durieux MEAnesthesiologySuccinylcholine: new insights into mechanisms of action of an old drug. Anesthesiology. 2006 Apr; 104(4):633-4.Anesthesiology2006-04-01T00:00:002006Succinylcholine: new insights into mechanisms of action of an old drug.23606469Bittner EA, Martyn JAJ, Gronert GAAnesthesia and analgesiaThe decision to use succinylcholine for critically ill patients should not be based on duration of time in the intensive care unit alone. Anesth Analg. 2013 May; 116(5):1182.Anesth Analg2013-05-01T00:00:002013The decision to use succinylcholine for critically ill patients should not be based on duration of time in the intensive care unit alone.3182535Kim C, Martyn J, Fuke NJournal of applied physiology (Bethesda, Md. : 1985)Burn injury to trunk of rat causes denervation-like responses in the gastrocnemius muscle. J Appl Physiol (1985). 1988 Oct; 65(4):1745-51.J Appl Physiol (1985)1988-10-01T00:00:001988Burn injury to trunk of rat causes denervation-like responses in the gastrocnemius muscle.